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19 pages, 1408 KB  
Article
Productivity and Economics of Puddled and Zero-Till Non-Puddled Transplanted Winter Rice Production Systems Under Varying Weed Management Practices
by A. K. M. Mominul Islam, Israt Jahan, Sabina Yeasmin, Sinthia Afsana Kheya, Md. Parvez Anwar and Md. Moshiur Rahman
Agrochemicals 2026, 5(3), 36; https://doi.org/10.3390/agrochemicals5030036 - 24 Aug 2026
Abstract
Effective weed management is critical to sustaining rice productivity and profitability, particularly under conservation-oriented production systems, where weed dynamics may differ from conventional puddled cultivation. A two-year field experiment was conducted to evaluate weed management practices under puddled transplanted rice (PTR) and zero-till [...] Read more.
Effective weed management is critical to sustaining rice productivity and profitability, particularly under conservation-oriented production systems, where weed dynamics may differ from conventional puddled cultivation. A two-year field experiment was conducted to evaluate weed management practices under puddled transplanted rice (PTR) and zero-till non-puddled transplanted rice (ZT NPTR) production systems during the boro seasons of 2020 and 2021. Six weed management practices, comprising season-long weed-free, season-long weedy, Pretilachlor, Acetachlor (14%) + Bensulfuron methyl (4%), Pyrazosulfuron-ethyl, and Penoxsulam treatments, were evaluated. Weed density and dry biomass were significantly influenced by production system and weed management practice. Compared with 2020, weed density in 2021 decreased by approximately 74% at both 30 and 60 days after transplanting (DAT) under PTR and by 91% and 86%, respectively, under ZT NPTR. Similarly, weed dry biomass decreased by 90% and 86% under PTR and by 81% and 77% under ZT NPTR at 30 and 60 DAT, respectively. Pyrazosulfuron-ethyl and Penoxsulam achieved 100% weed control efficiency, comparable to the season-long weed-free treatment, whereas Pretilachlor, and Acetachlor (14%) + Bensulfuron methyl (4%) provided comparatively lower weed suppression. The ZT NPTR system increased grain yield by approximately 5% in 2020 and 35% in 2021 relative to the PTR system. Among weed management practices, Penoxsulam produced the highest or a statistically comparable grain yield and increased yield by approximately 105% and 80% over the season-long weedy treatment in 2020 and 2021, respectively. Economic analysis showed that Pyrazosulfuron-ethyl was the most profitable treatment under PTR in both years and under ZT NPTR in 2021, whereas Penoxsulam provided the greatest economic return under ZT NPTR in 2020. Overall, effective post-emergence weed management with Pyrazosulfuron-ethyl or Penoxsulam within the ZT NPTR production system provided effective weed suppression, high rice productivity, and favourable economic returns. However, because pre-plant glyphosate application was an integral component of the ZT NPTR system, the differences between the PTR and ZT NPTR systems should be interpreted as responses to the overall production systems rather than to tillage alone. Full article
(This article belongs to the Section Herbicides)
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18 pages, 746 KB  
Article
Neuromuscular and Biomechanical Adaptations Following a 15-Week CrossFit-Based Functional Training Program in Competitive Sambo Athletes
by Cristian Dumitru Stanciu, Valentina Stefanica, Nicoleta Zaharie, Delia Badescu, Iulian Stoian, Ioan Teodor Hășmășan, Virgil Ene-Voiculescu, Denisa-Elena Hășmășan and Daniel Rosu
Appl. Sci. 2026, 16(16), 8345; https://doi.org/10.3390/app16168345 - 21 Aug 2026
Viewed by 88
Abstract
Background: Combat sports require athletes to repeatedly perform explosive actions under conditions of fatigue, demanding high levels of neuromuscular coordination, reactive agility, and intermittent effort capacity. This study examined changes in biomechanical and neuromuscular performance over a 15-week period during which competitive Sambo [...] Read more.
Background: Combat sports require athletes to repeatedly perform explosive actions under conditions of fatigue, demanding high levels of neuromuscular coordination, reactive agility, and intermittent effort capacity. This study examined changes in biomechanical and neuromuscular performance over a 15-week period during which competitive Sambo athletes completed a CrossFit-based functional training program alongside their regular sport-specific training. Methods: Forty male Sambo athletes (22.4 ± 2.6 years) completed a longitudinal repeated-measures intervention consisting of three weekly CrossFit-based sessions integrated into regular sport-specific training. The program was periodized across four progressive mesocycles emphasizing functional strength, explosive power, reactive agility, and fatigue resistance. Pre- and post-intervention assessments included upper- and lower-limb reaction speed, vertical jump height, repeated jump endurance, reactive agility, grip endurance, body-weight squat performance, Romanian deadlift repetitions, and the Special Judo Fitness Test (SJFT). Statistical analyses included paired-samples t-tests or Wilcoxon signed-rank tests with Benjamini–Hochberg false discovery rate correction (α = 0.05). Results: Significant post-intervention improvements were observed in most performance variables. Upper- and lower-limb reaction performance improved by 22.9% and 9.7%, respectively (p < 0.001), while vertical jump height increased by 11.4% and repeated jump endurance by 16.6% (p < 0.001). Reactive agility time decreased by 6.6% (p < 0.001), indicating faster cognitive-motor responsiveness. Functional strength improved substantially, with increases of 43.7% in body-weight squat performance and 71.9% in Romanian deadlift repetitions (p ≤ 0.001). Grip endurance improved by 6.3% (p = 0.007), whereas maximal handgrip strength showed no significant changes. The SJFT index decreased by 5.0% (p < 0.001), reflecting enhanced intermittent effort efficiency and fatigue tolerance. Large effect sizes were identified for upper-limb reaction speed (d = 1.42), explosive endurance (d = 1.46), and reactive agility (d = 0.96). Conclusions: Over the 15-week study period, participation in a CrossFit-based functional training program integrated into regular Sambo practice was associated with improvements in several biomechanical and neuromuscular performance outcomes, including reaction performance, explosive power, agility, muscular endurance, and sport-specific work capacity. However, because the study did not include a control group, these changes cannot be attributed exclusively to the CrossFit-based intervention. Controlled studies are required to distinguish intervention-specific effects from seasonal training adaptations, continued sport-specific practice, and test familiarization. Full article
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21 pages, 10743 KB  
Article
Enhancing Root Growth and Water Use Efficiency of Winter Wheat by Optimizing the Irrigation Amount of Micro-Sprinkler Irrigation
by Mingda Yang, Hui Cao, Jiaju Dong, Suyu Zhang, Hongjie Liu, Jinping Chen, Xiaoyun Zheng, Shenjiao Yang and Shoutian Ma
Plants 2026, 15(16), 2540; https://doi.org/10.3390/plants15162540 - 21 Aug 2026
Viewed by 67
Abstract
Conventional irrigation practices, characterized by excessive water application, have diminished water use efficiency (WUE) and intensified agricultural water consumption. Optimizing irrigation schedules and moderately reducing water input are therefore essential for enhancing WUE while safeguarding stable yields. Micro-sprinkler irrigation, which integrates the benefits [...] Read more.
Conventional irrigation practices, characterized by excessive water application, have diminished water use efficiency (WUE) and intensified agricultural water consumption. Optimizing irrigation schedules and moderately reducing water input are therefore essential for enhancing WUE while safeguarding stable yields. Micro-sprinkler irrigation, which integrates the benefits of both drip and sprinkler systems, represents a promising technology with substantial water-saving potential. However, its effects on root development and crop yield remain inadequately investigated. Here, we established three micro-sprinkler irrigation regimes—MS20 (20 mm), MS30 (30 mm), and MS40 (40 mm)—alongside flood irrigation (FI) and rainfed (RF) controls, to systematically assess their impacts on soil water content, root growth traits, dry matter accumulation, yield, and WUE. Compared with FI, MS treatments decreased profile soil water content at jointing but increased it in specific layers during grain filling, albeit to varying extents. MS treatments enhanced total root length density (TRLD) and total root dry weight density (TRDD) relative to FI, with MS20 significantly increasing both parameters in the 20–100 cm soil layer. Moreover, MS20 increased pre-flowering dry matter translocation (PDMT) by 9.69% on average and post-flowering dry matter accumulation (PFDMA) by 15.04% during the 2022–2023 season. Yield and WUE under MS treatments exceeded those under FI by 3.46–6.53% and 4.42–21.21%, respectively. Among the MS treatments, MS20 achieved the highest average WUE. No significant yield or WUE differences were observed between MS20 and MS30, with MS30 producing the numerically maximum average yield. MS40 did not significantly affect yield in 2021–2022; however, it substantially reduced both yield and WUE relative to MS20 and MS30 in 2022–2023. A comprehensive TOPSIS analysis identified the combination of micro-sprinkler irrigation with total seasonal irrigation amounts of 80 mm or 120 mm as the optimal strategy for winter wheat production in the eastern Henan region of the North China Plain (NCP). Full article
(This article belongs to the Section Crop Physiology and Crop Production)
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18 pages, 887 KB  
Article
Associations of Functional Movement Screen Scores and Joint Stability Tests with Non-Contact Lower-Limb Injury Burden in Collegiate Athletes
by Adam Eckart and Pragya Sharma-Ghimire
J. Clin. Med. 2026, 15(16), 6466; https://doi.org/10.3390/jcm15166466 - 21 Aug 2026
Viewed by 81
Abstract
Background: The ability of preseason screening to identify athletes at risk for non-contact lower-limb injury remains uncertain. Purpose: To determine whether knee and ankle joint tests, body mass index (BMI), prior lower-limb injury, and Functional Movement Screen (FMS) scores were associated with injury [...] Read more.
Background: The ability of preseason screening to identify athletes at risk for non-contact lower-limb injury remains uncertain. Purpose: To determine whether knee and ankle joint tests, body mass index (BMI), prior lower-limb injury, and Functional Movement Screen (FMS) scores were associated with injury and improved discrimination. Methods: Prospectively collected data from 381 collegiate athletes across 11 sports were retrospectively analyzed. Preseason assessments included BMI, injury history, FMS composite and subtest scores, and knee and ankle special tests summarized regionally. The primary outcome was two or more non-contact lower-limb injuries during the subsequent season; at least one injury was secondary. Hierarchical multivariable logistic regression, sex-stratified and sensitivity analyses, and cross-validated ridge logistic regression were performed. Results: Eighty athletes (21.0%) sustained at least one injury and 41 (10.8%) sustained two or more. Prior injury was associated with ≥2 injuries in Models 1 and 2 (odds ratios = 2.03 and 2.00, respectively) and remained the most consistent correlate across sensitivity analyses. Knee and ankle test findings and FMS composite scores were not consistently associated with injury in primary analyses. Exploratory subgroup associations included female BMI, In-Line Lunge, female Deep Squat, and male ankle instability without prior injury. For the primary outcome, apparent AUC was 0.621–0.649 and cross-validated AUC was 0.535–0.562; adding FMS variables did not improve cross-validated discrimination. Conclusions: Prior injury history was the most consistent risk marker, but the preseason battery showed limited generalizable predictive value. FMS and joint-test measures should not be used alone to predict individual injury risk. Full article
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17 pages, 2833 KB  
Article
Unravelling the Drivers of Early-Life Mortality in Yak Calves: A Retrospective Cohort Study Using Survival Analysis
by Asish Debbarma, Mokhtar Hussain, Martina Pukhrambam, Shubham Loat, Vijay Paul, Dinamani Medhi, Sayed Nabil Abedin and Mihir Sarkar
Animals 2026, 16(16), 2614; https://doi.org/10.3390/ani16162614 - 20 Aug 2026
Viewed by 148
Abstract
Early-life calf mortality is a significant barrier to herd growth and overall productivity in yak husbandry. This retrospective study investigated the survival pattern and potential risk factors linked to yak calf mortality during the first 90 days of life. Analysis was performed on [...] Read more.
Early-life calf mortality is a significant barrier to herd growth and overall productivity in yak husbandry. This retrospective study investigated the survival pattern and potential risk factors linked to yak calf mortality during the first 90 days of life. Analysis was performed on existing farm records from 428 yak calves born between 2013 and 2025 at a semi-intensive yak farm. The Kaplan–Meier method was used to estimate survival probability, and the log-rank test was used to compare survival probabilities; additionally, a multivariate Cox proportional hazards model was employed to identify independent risk factors. Overall, 70 (16.4%) calves died within the first 90 days after birth. The Kaplan–Meier analysis indicated significantly lower survival probability among low-birth-weight calves (≤12 kg; p = 0.0005) and calves born to primiparous dams (p = 0.0003). In contrast, survival did not differ according to calf sex (p = 0.620) and birth season (p = 0.658). In the multivariate Cox proportional hazards model, low birth weight (HR = 2.27, 95% CI: 1.24–4.16; p = 0.008) and primiparous dams (HR = 2.08, 95% CI: 1.28–3.38; p = 0.003) were independently associated with higher mortality risk. As a result, calf sex and birth season were not significant predictors. Diarrhea and respiratory disease were the predominant causes of calf deaths. The current study’s results indicate that maternal and neonatal factors are the major determinants of early-life calf survival. This highlights the need for special care with optimum nutrition and regular monitoring of primiparous dams and low-birth-weight calves in order to lower pre-weaning mortality and improve overall herd productivity. Full article
(This article belongs to the Section Animal System and Management)
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16 pages, 4143 KB  
Article
An Integrated Decentralised–Centralised Oncology Care Model to Improve Cancer Screening, Access, and Continuity of Care in Rural Eastern Cape, South Africa: Implementation Study at Nelson Mandela Academic Hospital
by Zukiswa Jafta, Muamabangu Jean Paul Milambo, Eric Maimela, Constance Rufaro Sewani-Rusike and Wilson Wezile Chitha
Int. J. Environ. Res. Public Health 2026, 23(8), 1079; https://doi.org/10.3390/ijerph23081079 - 19 Aug 2026
Viewed by 193
Abstract
Background: Rural and resource-constrained settings face major barriers to timely cancer screening, diagnosis, and treatment due to limited specialist availability and centralised service-delivery models. In the Eastern Cape, a largely rural province with a constrained oncology workforce, a decentralised–centralised hybrid model was introduced [...] Read more.
Background: Rural and resource-constrained settings face major barriers to timely cancer screening, diagnosis, and treatment due to limited specialist availability and centralised service-delivery models. In the Eastern Cape, a largely rural province with a constrained oncology workforce, a decentralised–centralised hybrid model was introduced to improve access to cancer care. Nelson Mandela Academic Hospital serves as the central referral hub within this model. This study evaluates the implementation process and impact of this decentralised cancer care model on service utilisation, access, and continuity of care. Methods: A quantitative quasi-experimental pre–post implementation and quality improvement evaluation was conducted using retrospectively collected routine service utilisation and programme data from April 2023 to February 2025. The study assessed the impact of a decentralised oncology care model on access, service integration, and utilisation outcomes. Data from facility registers and district health information systems were managed using Microsoft Excel and analysed using Stata and IBM SPSS Statistics. Descriptive statistics, correlation analysis, and linear regression were used to compare pre- and post-implementation changes in patient volumes, screening coverage, referral completion, workforce capacity, gender distribution, and service uptake. The intervention decentralised screening, diagnosis, follow-up, and patient navigation services to district and satellite facilities while centralising specialised oncology care at referral centres to improve accessibility, efficiency, and continuity of care. Results: Cancer patient attendance increased substantially over the study period, from 355 patients in April 2023 to a peak of 1039 in April 2024, with a sustained upward trend (B = 18.03, p = 0.005), reflecting an average monthly increase of 18 patients. Female patients accounted for most visits, while male attendance showed a significant increasing trend (B = 8.03, p < 0.001). Service integration improved, with strong positive correlations between new patient registrations, follow-up care, palliative services, and inpatient admissions, indicating an expanding continuum of care. Breast and cervical cancers contributed the highest service burden, while cervical and lung cancers showed significant upward trends. Seasonal variation in attendance was observed, particularly during festive periods. From an implementation perspective, screening coverage for priority cancers increased by 18%, while 732,349 individuals were reached through community awareness initiatives. Access improved substantially, evidenced by a reduction of 56,400 km in cumulative patient travel distance over one year. Workforce capacity was strengthened through the training of 517 healthcare workers, and 1943 patients received structured navigation support. Referral efficiency and continuity of care improved, although persistent bottlenecks were observed in diagnostic and referral pathways. Conclusions: The decentralised–centralised oncology care model demonstrated improved cancer service utilisation, access, and continuity of care in a rural, resource-limited setting. However, increasing patient volumes and interconnected service demands place additional pressure on health system capacity. Sustained investment in workforce development, screening—particularly for cervical cancer—and system efficiency is required. This model provides a scalable and context-appropriate framework for strengthening oncology services in similar low-resource settings. Full article
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17 pages, 1528 KB  
Article
Patterns and Predictors of Influenza Vaccination Uptake Among Healthcare Personnel in Kuwait: A Nationwide Multi-Season Study
by Saleh Alsarhan, Fatema Alkhulaifi and Lolwah Alzafiri
Vaccines 2026, 14(8), 712; https://doi.org/10.3390/vaccines14080712 - 19 Aug 2026
Viewed by 187
Abstract
Background/Objectives: Healthcare personnel (HP) are a priority group for seasonal influenza vaccination due to their increased occupational exposure and potential to transmit influenza in healthcare settings. This study examined patterns and factors associated with in-season influenza vaccination uptake among HP in Kuwait. [...] Read more.
Background/Objectives: Healthcare personnel (HP) are a priority group for seasonal influenza vaccination due to their increased occupational exposure and potential to transmit influenza in healthcare settings. This study examined patterns and factors associated with in-season influenza vaccination uptake among HP in Kuwait. Methods: A nationwide observational study was conducted using Ministry of Health (MOH) administrative records covering the 2022/2023 through 2024/2025 influenza seasons. A person–season dataset was constructed, comprising one observation per HP for each of the three seasons. The primary outcome was in-season influenza vaccination, defined as receipt of an influenza vaccine between September and March of a given study season. Independent variables included age, sex, nationality, governorate of residence, profession, managerial position, previous-year influenza vaccination status, and pre-season sickness absence duration (days). Generalized estimating equations (GEE) logistic regression model with an exchangeable correlation structure was used to estimate factors associated with vaccination uptake. Results: The final analytic dataset included 48,886 HP contributing 146,658 person–season observations across three influenza seasons. Overall, in-season vaccination uptake was 8.7%, and repeated vaccination across seasons was uncommon. Older age, male sex, non-Kuwaiti nationality, and being a physician were independently associated with higher odds of in-season influenza vaccination. Previous-year influenza vaccination was the strongest predictor of current-season vaccination uptake (aOR 2.01, 95% CI 1.87–2.16; p < 0.001). Compared with HP with no pre-season sickness absence, those with 1–3 pre-season sickness absence days had slightly higher adjusted odds of vaccination (aOR 1.08, 95% CI 1.03–1.14), whereas those with ≥8 days had lower adjusted odds (aOR 0.91, 95% CI 0.85–0.97). Conclusions: In-season influenza vaccination uptake among HP in Kuwait was low across three consecutive influenza seasons, with limited continuity of annual vaccination. Previous-year vaccination was the strongest predictor of current-season vaccination uptake, while the association between pre-season sickness absence and vaccination varied by absence duration. These findings support continued efforts to improve and sustain in-season influenza vaccination uptake among HP, while further research is needed to clarify the factors underlying vaccination decisions. Full article
(This article belongs to the Section Influenza Virus Vaccines)
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18 pages, 17215 KB  
Article
Field Evidence: Microbial Fertilizer Drives Rhizosphere Phosphorus Transformation and Acidity Regulation to Synergistically Promote Chlorogenic Acid Accumulation in Lonicera macranthoides
by Yong Wang, Kuaifen Li, Huarong Qiu, Qiuju Jiang, Qian Ding, Tangyan Li, Hua Feng and Xianyu Deng
Microorganisms 2026, 14(8), 1816; https://doi.org/10.3390/microorganisms14081816 - 18 Aug 2026
Viewed by 199
Abstract
Microbial fertilizers may improve phosphorus availability and pH in acidic soils, but field evidence linking these changes with medicinal plant biomass and specialised metabolite accumulation remains limited. Here, a one-season field experiment was conducted in acidic yellow soil in Guizhou Province, China, using [...] Read more.
Microbial fertilizers may improve phosphorus availability and pH in acidic soils, but field evidence linking these changes with medicinal plant biomass and specialised metabolite accumulation remains limited. Here, a one-season field experiment was conducted in acidic yellow soil in Guizhou Province, China, using four fertilization regimes for Lonicera macranthoides: an organic fertilizer plus compound fertilizer control (CK), a bacterial consortium (T1), a simplified bacterial combination (T2), and a fungal agent (T3). Soil chemical properties, soil aggregate composition, flower-bud biomass, and chlorogenic-acid-related compounds were measured. T1 and T3 increased soil available phosphorus and pH at the pre-flowering stage and increased the proportion of water-stable macroaggregates (>5 mm). Both treatments also increased fresh and dry biomass. T1 showed the highest numerical chlorogenic acid content, whereas T3 was more favourable for the accumulation of isochlorogenic acids A and C. Across plot-level observations, available phosphorus was positively correlated with fresh weight (r = 0.804) and dry weight (r = 0.781), and pH was positively correlated with chlorogenic acid (r = 0.687). Univariate regression and redundancy analysis further indicated that available phosphorus and pH were the soil factors most closely associated with biomass and chlorogenic acid accumulation. These findings provide preliminary field indications that microbial fertilizers may improve yield and medicinal quality in acidic-soil L. macranthoides production. However, the single-season, single-site nature of the experiment warrants cautious interpretation and further validation across broader conditions. The observed associations are consistent with, but do not prove, a mechanistic pathway involving microbe-mediated phosphorus transformation and acidity regulation. Full article
(This article belongs to the Section Plant Microbe Interactions)
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25 pages, 6666 KB  
Article
Data Quality Analysis of Wet Atmospheric Temperature Profiles from the YunYao Meteorological Constellation Radio Occultation
by Jiahao Liang, Lvyi Zhang, Zijing Liu and Jie He
Remote Sens. 2026, 18(16), 2733; https://doi.org/10.3390/rs18162733 - 14 Aug 2026
Viewed by 170
Abstract
Radio occultation offers high vertical resolution, global coverage, and low sensitivity to clouds and precipitation, making it a useful complement to existing atmospheric sounding techniques. The YunYao constellation, the first commercial meteorological remote sensing constellation of China, supplies a large number of GNSS-RO [...] Read more.
Radio occultation offers high vertical resolution, global coverage, and low sensitivity to clouds and precipitation, making it a useful complement to existing atmospheric sounding techniques. The YunYao constellation, the first commercial meteorological remote sensing constellation of China, supplies a large number of GNSS-RO temperature profile products, yet the quality of its wet atmospheric profiles remains undocumented. Using operational radiosonde data from 43 stations over southern China (97–123°E, 17–31°N) during boreal winter and early spring (1 November 2025 to 31 March 2026) as reference, this study evaluates the accuracy, error characteristics, and applicability of the YunYao wet atmospheric temperature profile product, with COSMIC-2 as an independent benchmark. YunYao yields 4.77 times the matched sample volume of COSMIC-2 over the same domain and period, while its RMSE is only 0.20–0.42 °C higher. Within 50–925 hPa, the YunYao profiles agree closely with radiosondes, with RMSE generally within 1–2 °C, a weak, spatially uniform cold bias, and small diurnal differences. Below 925 hPa, near-surface error grows markedly, dominated by enhanced random error rather than systematic error, with inland cold and coastal warm bias. A January maximum of random error is possibly related to super-refraction during peak winter monsoon cold surges, and a March sign reversal of the bias possibly related to the seasonal increase in boundary layer moisture ahead of the pre-flood season. With weak cold bias correction, YunYao temperature profiles are highly usable within 50–925 hPa, while data below 925 hPa require strict quality control. Full article
(This article belongs to the Special Issue BDS/GNSS for Earth Observation (Third Edition))
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21 pages, 3046 KB  
Review
Advances in the Development of a Universal Influenza Vaccine
by Preanka Mudaly, Max Lee, Aishwarya Bhatta and Craig Thompson
Antibodies 2026, 15(4), 75; https://doi.org/10.3390/antib15040075 - 11 Aug 2026
Viewed by 295
Abstract
Influenza remains a persistent global health threat, accounting for an estimated one billion infections and 350,000–600,000 deaths worldwide annually. Beyond substantial mortality and morbidity, influenza imposes major socio-economic costs through healthcare utilisation and productivity losses, amounting to tens of billions of dollars each [...] Read more.
Influenza remains a persistent global health threat, accounting for an estimated one billion infections and 350,000–600,000 deaths worldwide annually. Beyond substantial mortality and morbidity, influenza imposes major socio-economic costs through healthcare utilisation and productivity losses, amounting to tens of billions of dollars each year. Current seasonal vaccination strategies are constrained by rapid antigenic evolution, which necessitates frequent vaccine reformulation and contributes to suboptimal vaccine efficacy across seasons. These drawbacks highlight the need for a universal influenza vaccine (UIV) that protects against all seasonal and potential pandemic influenza strains via a single dose. This review evaluates the feasibility of a UIV as an alternative to a seasonal influenza vaccine (SIV) by consolidating evidence from current UIV candidates in preclinical and clinical development across a diverse range of platforms and target epitopes. Preclinical studies and clinical trials have demonstrated the safety and tolerability of multiple candidates, as well as their ability to elicit broadly cross-reactive immune responses. However, several challenges remain regarding the long-term efficacy of these vaccines. In particular, pre-existing host immunity can shape subsequent vaccine responses, with immune imprinting introducing biases toward previously encountered influenza strains, potentially reducing vaccine effectiveness. In addition, the genetic plasticity of influenza viruses, driven by ongoing mutations and genetic reassortment, raises concerns about the ability of a single vaccine formulation to maintain broad and durable protection. Overall, several UIV candidates have shown promising early results. Although ecological and immunological barriers remain, a UIV could become a viable alternative to, or eventual replacement, for SIVs. Full article
(This article belongs to the Section Antibody-Based Therapeutics)
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12 pages, 381 KB  
Article
Short-Term Changes, Individual Variability, and Associations with Baseline Physical Performance in Young Male Soccer Players During the Pre-Season
by Artur Avelino Birk Preissler, Filipe Manuel Clemente, Ana Filipa Silva, Rui Sousa Mendes and Pedro Schons
Sports 2026, 14(8), 344; https://doi.org/10.3390/sports14080344 - 10 Aug 2026
Viewed by 186
Abstract
Monitoring physical performance during the pre-season may help coaches and practitioners interpret short-term changes in young soccer players, although group-level analyses may mask individual variability. This observational longitudinal study analyzed short-term changes, individual variability, and associations between baseline performance and change magnitude in [...] Read more.
Monitoring physical performance during the pre-season may help coaches and practitioners interpret short-term changes in young soccer players, although group-level analyses may mask individual variability. This observational longitudinal study analyzed short-term changes, individual variability, and associations between baseline performance and change magnitude in 50 under-17 male outfield soccer players during a 47-day pre-season. Physical performance was assessed before and after the pre-season using the squat jump (SJ), countermovement jump (CMJ), 20 m linear sprint (Sprint-20m), 20 m change-of-direction test (COD-20m), and Yo-Yo Intermittent Recovery Test Level 1 (Yo-Yo IRL1). Significant improvements were observed in SJ (+1.43 cm, p < 0.001), CMJ (+1.37 cm, p < 0.001), and COD-20m (+0.31 km·h−1, p < 0.001), whereas no statistically significant changes were detected in Sprint-20m (−0.14 km·h−1, p = 0.121) or Yo-Yo IRL1 (−26.20 m, p = 0.721). Individual changes were heterogeneous, with 68.0% improving in SJ and COD-20m, 64.0% in CMJ, 40.0% in Sprint-20m, and 54.0% in Yo-Yo IRL1. Exploratory inverse associations were observed between baseline performance and change scores for SJ (ρ = −0.35, p = 0.014), CMJ (ρ = −0.40, p = 0.004), and COD-20m (ρ = −0.30, p = 0.033), whereas no statistically significant associations were detected for Sprint-20m or Yo-Yo IRL1. These findings support integrating group-level changes, individual variability, and baseline-performance context when interpreting short-term physical performance monitoring in youth soccer. Full article
(This article belongs to the Special Issue Sport-Specific Testing and Training Methods in Youth: 2nd Edition)
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16 pages, 3397 KB  
Article
Contrasting Water-Use Strategies of Ailanthus altissima and Crataegus orientalis Under Drought Stress Reveal Restoration Potential in Mediterranean Drylands
by Bülent Akgün, Emre Yazar, Ömer Buğday, Martin Battaglia and Emre Babur
Water 2026, 18(16), 1952; https://doi.org/10.3390/w18161952 - 10 Aug 2026
Viewed by 355
Abstract
Water availability is the primary environmental factor limiting plant establishment in arid and semi-arid ecosystems, and increasing drought-stress due to climate change is making forest restoration efforts in the Mediterranean basin increasingly critical. The Eastern Mediterranean region of Türkiye, particularly Kahramanmaraş Province, is [...] Read more.
Water availability is the primary environmental factor limiting plant establishment in arid and semi-arid ecosystems, and increasing drought-stress due to climate change is making forest restoration efforts in the Mediterranean basin increasingly critical. The Eastern Mediterranean region of Türkiye, particularly Kahramanmaraş Province, is characterized by increasingly severe drought stress resulting from low natural precipitation and rising temperatures under global warming. This study comparatively evaluates the ecophysiological responses of Ailanthus altissima (Mill.) Swingle and Crataegus orientalis Pall. ex M. Bieb., under adequate irrigation and drought-stress conditions. To determine plant water status, pre-dawn and midday leaf water potentials were measured, and leaf gas exchange was characterized by measuring net photosynthesis (A), stomatal conductance (gs), and transpiration rate (E); water-use efficiency (WUE) was then derived from these parameters as the ratio of net photosynthesis to transpiration (A/E). Both species sustained positive net photosynthesis under drought, although at rates significantly below those of the well-watered controls in the driest months, and both attained higher WUE than the controls in most months, with marked seasonal variation. However, significant differences in physiological adaptation strategies emerged between the species. Ailanthus altissima exhibited a water-saving strategy, restricting stomatal conductance to maintain a stable leaf water status, whereas Crataegus orientalis adopted a water-spending strategy, sustaining high leaf gas exchange while tolerating pronounced tissue dehydration. Modeling results, supported by spatial drought stress indices, have shown that both species have high adaptation potential in arid and semi-arid rehabilitation areas. The findings reveal that ecophysiological characteristics play a critical role in the selection of drought-tolerant woody species and provide a scientific basis for sustainable forest restoration under climate change. Full article
(This article belongs to the Special Issue Resilient Water Management in Arid and Semi-Arid Agroecosystems)
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10 pages, 878 KB  
Brief Report
An Overview of Antibiotic Consumption in Croatian Counties, 2017–2024: Temporal and Geographic Patterns Before, During, and After the COVID-19 Pandemic
by Sanda Tešanović, Ljiljana Betica Radić, Ankica Džono Boban, Pero Draganić and Maja Radman
Pharmacoepidemiology 2026, 5(3), 28; https://doi.org/10.3390/pharma5030028 - 7 Aug 2026
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Abstract
Background/Objectives: Croatia is among the European countries with moderately high antibiotic consumption and correspondingly elevated antimicrobial resistance (AMR) rates. National-level surveillance, however, masks substantial county-level heterogeneity that is relevant for targeted stewardship. This study aimed to (i) quantify and statistically test temporal changes [...] Read more.
Background/Objectives: Croatia is among the European countries with moderately high antibiotic consumption and correspondingly elevated antimicrobial resistance (AMR) rates. National-level surveillance, however, masks substantial county-level heterogeneity that is relevant for targeted stewardship. This study aimed to (i) quantify and statistically test temporal changes in total antibacterial consumption (J01), beta-lactam antibiotics (J01C), and macrolides/lincosamides/streptogramins (J01F) across all 21 Croatian counties between 2017 and 2024, spanning the pre-pandemic, pandemic, and post-pandemic periods, and (ii) characterize geographic disparities that could inform region-specific stewardship interventions. J01C and J01F were selected because they are, respectively, the most heavily consumed and the most steadily rising antibiotic subgroups in Croatia, and both carry direct relevance to the WHO Access, Watch, Reserve (AWaRe) stewardship framework. Methods: A retrospective, registry-based analysis of antibiotic consumption in all 21 Croatian counties was conducted using annual distribution data from the Croatian Agency for Medicinal Products and Medical Devices (HALMED), covering 1 January 2017 to 31 December 2024. Consumption was expressed as defined daily doses per 1000 inhabitants per day (DDD/TID). County-level values for 2017, 2020, 2021, and 2024 were compared using paired Student’s t-tests (confirmed with Wilcoxon signed-rank tests) and a Friedman test across all four time points; national annual means (2017–2024) were compared descriptively against European Union/European Economic Area (EU/EEA) surveillance benchmarks. Results: National J01 consumption declined from 21.16 to 16.96 DDD/TID between 2017 and 2021 (−19.8%) and rebounded to 22.75 DDD/TID by 2024 (+34.1%); the county-level decline and rebound were both statistically significant (paired t-tests, p < 0.001 for each comparison; Friedman χ2 = 57.97, p < 0.001). J01C followed the same U-shaped pattern, temporally coincident with the COVID-19 pandemic period (12.59 → 5.13 → 9.05 DDD/TID; all comparisons p < 0.001), whereas J01F rose continuously throughout the study period, without a corresponding dip during that period (2.81 → 3.49 → 4.43 DDD/TID; p < 0.001 for every interval). Croatia’s 2024 mean county-level J01 consumption was significantly above the 2024 EU/EEA population-weighted mean of 18.8 DDD/TID (one-sample t-test, p = 0.016). The sharpest pandemic-era declines and post-pandemic rebounds were concentrated in Adriatic coastal counties (Primorje-Gorski Kotar, Zadar, Šibenik-Knin, and Istria). Conclusions: Total and beta-lactam antibiotic consumption in Croatia followed a U-shaped trajectory temporally coincident with the COVID-19 pandemic period, while macrolide, lincosamide, and streptogramin use rose steadily throughout 2017–2024, a pattern of stewardship concern given that this subgroup is predominantly classified as “Watch” under the WHO AWaRe framework. Coastal counties displayed disproportionate fluctuations, plausibly reflecting seasonal population dynamics not captured by resident-population denominators. AWaRe-stratified, tourism-adjusted, county-level surveillance is recommended to guide targeted stewardship. Full article
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13 pages, 513 KB  
Article
A Position-Specific, Time-Efficient Warm-Up Injury Prevention Program in Male Football Players: A Season-Long Intervention Study
by Dimitrios Vlachodimos, Athanasios A. Dalamitros, Vasiliki Manou, Thomas Metaxas, Nikolaos Stavropoulos and Ioannis Terzidis
Sports 2026, 14(8), 340; https://doi.org/10.3390/sports14080340 - 7 Aug 2026
Viewed by 861
Abstract
This study assessed the effectiveness of a position-specific and time-efficient warm-up injury prevention program for male football players. This season-long quasi-experimental study included 129 male amateur football players. A structured injury prevention program was incorporated into the warm-up routine during the preseason and [...] Read more.
This study assessed the effectiveness of a position-specific and time-efficient warm-up injury prevention program for male football players. This season-long quasi-experimental study included 129 male amateur football players. A structured injury prevention program was incorporated into the warm-up routine during the preseason and competitive season. Prospectively collected injury data from the intervention season were compared with retrospectively collected injury data from the previous season and included injury incidence, the number of injured players, injury severity, and injury burden. The program included general exercises and position-specific modifications for defenders, midfielders, and attackers. Implementation of the program was associated with a 60% reduction in total injuries (p < 0.05) and a 60.3% reduction in total injured players The injury burden was significantly reduced (p < 0.05), as indicated by a reduced mean day lost per injury from 33.24 to 19.56 days. Although injury reductions were observed across all playing positions, between-position differences were not statistically significant. The type of injuries and their mechanisms were not significantly affected. These preliminary, associative findings suggest that a time-efficient, position-specific warm-up program may contribute to reduced injury occurrence in amateur football; however, given the quasi-experimental design, confirmation through randomized controlled trials is required. Full article
(This article belongs to the Special Issue Improving Health and Performance in Football)
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18 pages, 8556 KB  
Article
Locally Assembled, Cost-Effective Creepmeters for Monitoring Aseismic Creep Displacement Along the West Valley Fault (Philippines)
by Rolly E. Rimando, Deo Carlo E. Llamas and Bryan J. Marfito
GeoHazards 2026, 7(3), 96; https://doi.org/10.3390/geohazards7030096 - 6 Aug 2026
Viewed by 569
Abstract
Arduino-based creepmeters utilizing a Linear Variable Differential Transformer (LVDT) and ultrasonic sensors were fabricated to monitor displacement changes along the creeping segment of the West Valley Fault (WVF) in southeastern Metro Manila, Philippines. Along with a custom-assembled, Arduino-based rain gauge, these instruments were [...] Read more.
Arduino-based creepmeters utilizing a Linear Variable Differential Transformer (LVDT) and ultrasonic sensors were fabricated to monitor displacement changes along the creeping segment of the West Valley Fault (WVF) in southeastern Metro Manila, Philippines. Along with a custom-assembled, Arduino-based rain gauge, these instruments were initially intended to prevent data gaps during the COVID-19 pandemic when commercial data recorders experienced operational downtime. However, they have since proven to be cost-effective alternatives for determining short-term slip rates and monitoring displacement variations driven by episodic and seasonal precipitation changes. The LVDT creepmeter provides higher accuracy for displacement and slip rate determination. Conversely, the ultrasonic creepmeter is better suited for tracking abrupt displacement changes and, to some extent, longer-term displacement trends as it is more sensitive to environmental conditions. Deploying low-cost monitoring instruments in active fault regions bridges critical data gaps and improves the understanding of creep triggers and mechanisms. Although vertical creep occurs along pre-existing tectonic features of the WVF creeping segment, our creepmeter monitoring reveals sustained, accelerated creep within its southern portion. This localized movement is driven primarily by nontectonic forces—chiefly groundwater extraction, with episodic and seasonal precipitation influences. Consequently, this implies a continued ground rupture hazard and the potential for induced seismicity. Full article
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