Search Results (7,681)

Volatile organic compounds (VOCs) are ubiquitous pollutants, and exposure from in utero through childhood may impair neurodevelopment. However, compound-specific risks remain unclear. This systematic review and meta-analysis examined associations between VOC exposure and child neurodevelopmental outcomes. A systematic search of PubMed, Scopus, and Embase was conducted until August 2025, yielding 1213 records. Quality assessment was performed using the Newcastle–Ottawa Scale and risk of bias using the ROBINS-E tool. Pooled odds ratios (ORs) were calculated using random-effects models, with heterogeneity evaluated via I² statistics. Subgroup analyses explored for study design, exposure timing, and country income level. Twenty-eight studies were included in the final analysis. Of the 18 VOCs analyzed, five compounds, propionaldehyde (pooled OR = 1.84; 95% CI 1.19–2.49), styrene (pooled OR = 1.69; 95% CI 1.30–2.21), vinyl chloride (pooled OR = 1.53; 95% CI 1.24–1.89), acrolein (pooled OR = 1.48; 95% CI 1.08–2.04), and trichloroethylene (OR = 1.21; 95% CI 1.04–1.41), demonstrated statistically significant adverse associations with neurodevelopment. Benzene showed borderline significance. Heterogeneity ranged from 0–47%. Subgroup analyses identified significant effect modification for 1,3-butadiene by study design and exposure timing and higher pooled estimates for ethylbenzene in high-income countries. Full article

This review examines microplastics (MPs) in aquatic environments, their interactions with organic pollutants (OPs), effects on organisms, and implications for human and ecological health. MPs are ubiquitous, persistent contaminants. Their small size and large surface area enhance adsorption of diverse OPs; however, the extent to which MPs influence pollutant transport, fate, and bioavailability remains highly context-dependent and is still under scientific debate. Sorption processes are influenced by polymer type, pollutant properties, environmental factors, and aging processes that increase surface reactivity, further contributing to the variability of MP–OP interactions. Detection of MPs in human tissues raises concerns about long-term health effects, including inflammatory, immune, gastrointestinal, respiratory, and endocrine responses. Despite advances in analytical techniques, challenges remain in identifying and quantifying small particles in complex matrices. This review emphasizes the need for integrated, multi-technique, and environmentally realistic studies to understand MP–OP interactions and support risk assessment. Future research should focus on standardizing methodologies, improving nano-sized particle detection, and elucidating long-term effects, including trophic transfer and potential tissue accumulation. Full article

Freshwater scarcity is a major global issue faced by various regions, and the most common portable water sources globally are estuaries, canals, dams, lakes, and rivers. Existing water resources function as the best sinks for the frequent release of effluents from industrial and residential activities. This common practice often results in water pollution, a deterioration in marine biodiversity, and possible health risks for human populations. This study employed standard analytical methods in assessing the physicochemical and microbial characteristics of water samples collected from the Sundays River estuary in Eastern Cape Province (ECP), South Africa (SA). Microbiological assessment revealed that during the spring season, presumptive Escherichia coli (E. coli) colony counts were 1 cfu/100 mL, while total coliforms (TCs) and fecal coliforms (FCs) were recorded at 42.67 cfu/100 mL and 1 cfu/100 mL, respectively. In the summer season, fecal coliform (FC) counts reached 3.5 cfu/100 mL, while Enterococcus levels were higher, ranging up to 77.75 cfu/100 mL. Furthermore, the average standards of physicochemical parameters assessed in water obtained from both spring and summer seasons ranged as follows: pH (8.71–9.31), temperature (20.98–22.21 °C), turbidity (10–35.55 FNU), total alkalinity (22.25–94.00 mg/L), oxidation–reduction potential (ORP) (8.05–151.6 mV), electrical conductivity (EC) (13,915–40,260 uS/cm), salinity (8.07–25.78 psu), dissolved oxygen (DO) (6.79–7.39 mg/L), total dissolved solids (TDSs) (6960.6–20,125 mg/L), and biochemical oxygen demand (BOD) (0.11–2.94 mg/L). The levels of TDS, EC, turbidity, and salinity in the Sundays River estuary water exceeded the World Health Organization (WHO) guidelines of 2017, rendering the water unfit for even recreational purposes. Additionally, the bacterial levels identified in this study were above the values set by the South Africa Department of Water Affairs (SA-DWAF). The identified microorganisms are perceived as essential indicators of fecal contamination and have the potential to multiply in the environment. Possible pollution may be a result of various municipal effluents consistently discharged into the waterbody. Full article

Particulate matter is a significant component of air pollutants, especially PM_2.5-bound polycyclic aromatic hydrocarbons (PAHs), due to multiple toxicological effects on organisms. In this study, the concentrations of PM_2.5-bound PAHs at the two most important ports in Mexico (Veracruz and Manzanillo) were determined to identify emission sources and evaluate potential health impacts. Average PM_2.5 concentrations were higher in Veracruz (12.90 ± 4.77 μg/m³) than in Manzanillo (10.96 ± 3.99 μg/m³), although both were below Mexico’s current air quality standards. Total PAH concentrations were also higher in Veracruz (22.14 ± 16.76 ng/m³) compared to Manzanillo (11.65 ± 9.04 ng/m³). The identified PAHs and diagnostic ratios indicated different emissions patterns: in Manzanillo, concentrations were associated with high-temperature pyrogenic sources, while in Veracruz, greater contributions from mixed sources were observed. The ILCR assessment was 4.61 × 10⁻⁷ for Manzanillo and 8.77 × 10⁻⁷ for Veracruz, both below the accepted risk threshold. Despite relatively low health risk estimates, the presence of carcinogenic PAHs, such as benzo[a]pyrene, highlights the need for continuous monitoring and mitigation strategies in port environments. These results provide pioneering, highly valuable insights into the dynamics of air pollution in these Mexican ports and their potential health implications. Full article

Against the backdrop of increasing challenges posed by ongoing climate change, pollution and its associated implications and environmental and climate protection measures have become the focus of politics and society in recent years. But adaptation and mitigation require changes in behavior among the population. This means that a process of social transformation must take place. Based on the thesis that people working in healthcare facilities can make a relevant contribution to the social transformation of environmental awareness, this study examines the general and workplace-related environmental awareness of hospital employees. Risk awareness, measure effectiveness, transformation costs and the subjective social norm factors were included, which eventually influence this awareness. Therefore, a mixed study design consisting of an original study and a systematic replication study was used. Data were analyzed using structural equation modeling (path analysis) to identify key predictors of environmental awareness and behavior. The results show that hospital employees generally have a high level of environmental awareness compared to the general population in Germany. This is also evident in their awareness of workplace-related measures. However, influencing factors such as transformation costs in particular mean that measures, even if they are considered effective, are only implemented to a limited extent by hospital employees. With regard to the question of whether hospital employees can play a key role in the social transformation process, this study does not provide sufficient evidence to answer this question. Full article

Background: Cephalosporins, widely used β-lactam antibiotics, are becoming significant environmental pollutants, primarily due to their high use and persistence. They are released into the environment mainly through wastewater treatment plants, agricultural runoff, and hospital discharge, with particularly high concentrations recorded in effluents. Conventional wastewater treatment methods have inadequate removal efficiency, while advanced treatments, such as ozonation, activated carbon adsorption, and advanced oxidation processes, although more efficient, may produce toxic by-products. Recent studies emphasize the importance of improved detection and monitoring techniques and advocate for stricter effluent regulations. Despite growing research attention, important knowledge gaps remain, including limited long-term field monitoring, insufficient data on environmentally realistic exposure scenarios, and incomplete assessment of transformation-product toxicity. Methods: The search strategy used the SCOPUS and PUBMED databases with the keywords “cephalosporin” AND “aquatic environment”, resulting in 341 records. After applying predefined inclusion and exclusion criteria, 110 peer-reviewed English-language studies meeting predefined thematic inclusion criteria and relevant to the occurrence, environmental fate, ecotoxicological effects, antimicrobial resistance, and removal of cephalosporins in aquatic environments were included in the narrative synthesis. Results: The literature on cephalosporins in aquatic environments has expanded significantly from 1978 to 2025, prompted by concerns about pharmaceutical contamination and antibiotic resistance. Studies from 2016 to 2025 used advanced and multidisciplinary monitoring techniques, revealed key pollution sources such as wastewater treatment plants and hospitals, and correlated antibiotic residues with resistance genes, highlighting the need for continued monitoring and mitigation efforts. Ecotoxicological and fate studies further indicate that transformation processes may generate products with altered or increased toxicity, complicating environmental risk assessment. Conclusions: The literature shows increasing attention to cephalosporins in aquatic environments, reporting associations with antimicrobial resistance and adverse effects on aquatic organisms, including potential toxicity from transformation products. This review highlights the need for integrated monitoring, standardized toxicity assessment, and improved treatment strategies within a One Health framework. Full article

The identification and characterization of air pollutants in metropolitan environments are of paramount global concern due to their significant implications for air quality and public health. This study investigates the chemical composition of fine particulate matter (PM_2.5) at two strategically selected urban sites in Seoul, South Korea, during 2020: Gwanghwamun Plaza, representing a high-density central location, and Bokjeong Station, situated in the metropolitan periphery. A key aspect of this research is the detection of terephthalic acid (TPA)—a distinct marker of polyethylene terephthalate (PET) combustion—using high-resolution liquid chromatography–time-of-flight tandem mass spectrometry (LC-ToF-MS/MS). Results from the simultaneous measurement campaign demonstrate that nighttime conditions strongly influence PM_2.5 at both sites, with increases observed not only in absolute concentrations (levoglucosan, TPA, As, CO, and NH₃) but also in OC-normalized ratios (levoglucosan/OC and TPA/OC). The consistent nighttime enhancement of these ratios suggests that the observed increases cannot be explained solely by reduced planetary boundary layer height but instead indicate relatively stronger emission contributions. These increases are likely influenced by waste incineration activities, wherein PET-based plastics and wood materials are combusted. Furthermore, assessment of the dithiothreitol assay-derived oxidative potential (DTT-OP) underscores the heightened oxidative stress associated with these emissions, posing substantial health risks. Full article

Bottom sediments in anthropogenically impacted freshwater systems represent a dynamic and poorly constrained source of secondary pollution, where heavy metal mobility, rather than total concentration, controls the release of contaminants into the water column under changing physicochemical conditions. This issue is particularly pronounced in small and medium-sized freshwater systems subjected to sustained anthropogenic pressure, where local hydrochemical conditions and sediment composition strongly influence metal speciation and remobilization dynamics. This study aims to quantitatively assess heavy metal speciation, mobility, and associated ecological risk in bottom sediments of anthropogenically impacted freshwater systems using complementary analytical approaches. The data obtained indicate a pronounced spatial heterogeneity in the total metal content, due to varying degrees of anthropogenic impact on the water bodies. The highest level of pollution was recorded in the bottom sediments of the Chizhovskoye reservoir, where Zn concentrations reach 755 mg/kg, Cr—379 mg/kg, Ni—106 mg/kg, and Cu—158 mg/kg, indicating intense technogenic influence. The bottom sediments of the Loshitsa River are characterized by elevated, but less extreme values: the content of Cu is up to 77 mg/kg, Zn—up to 263 mg/kg, and Mn—up to 418 mg/kg. In contrast to urbanized water bodies, the background site—Lake Sergeevskoye—is characterized by significantly lower concentrations of heavy metals, which confirms its representativeness as a control object. Analysis of the fractional composition showed that Zn and Mn have the largest share of mobile forms, with their concentrations in the mobile phase reaching 12–92 mg/kg and 60–116 mg/kg, respectively, especially under conditions of increased anthropogenic load. A significant portion of Cu and Zn (up to 60–70% of the total content) is associated with organic matter, indicating the important role of the organic matrix in retaining metals and their potential mobilization under changing environmental conditions. Calculation of the geoaccumulation index showed that most of the studied bottom sediments belong to the from uncontaminated to moderately contaminated class, while for Cr and Ni in the Chizhovskoye reservoir, I_geo values up to 1.9 are characteristic, corresponding to a moderate level of pollution. The results obtained indicate a significant impact of anthropogenic load on the forms of occurrence and mobility of heavy metals and highlight the role of bottom sediments as an active factor in the secondary pollution of freshwater ecosystems. Full article

Leaching carbon residue (LCR) is a carbonaceous solid waste generated during the hydrometallurgical recycling of spent lithium-ion batteries. Although its high graphite content offers substantial potential for resource recovery, the residual heavy metals and fluorides present in LCR pose considerable environmental risks. Currently, LCR has not garnered sufficient attention within the industry, and the lack of recycling technologies suitable for large-scale disposal results in resource wastage and environmental pollution. To address these challenges, this study proposes an innovative strategy based on the concept of multi-field synergistic enhancement. The proposed approach involves recovering and regenerating graphite (RG) from LCR via low-temperature molten salt roasting assisted by high-pressure and mechanical activation. A combination of advanced characterization techniques was employed to compare the physicochemical properties of RG and commercial graphite (CG) and to systematically evaluate the technical feasibility of using regenerated graphite as an anode material for lithium-ion batteries. The results demonstrate that, under optimized molten salt roasting and aqueous leaching conditions, the carbon content of RG reaches 99.94 wt%, indicating the efficient removal of non-carbon impurities from the graphite matrix. Compared to CG, RG retains a typical layered structure; however, a lower carbon content (99.94 wt%) and poorer structural order (I_D/I_G = 0.30) are observed. In terms of electrochemical performance, RG delivers a discharge specific capacity of 394.64 mAh/g during the first cycle and exhibits excellent cycling stability, with a capacity retention of 86.50% after 100 cycles. This electrochemical performance is comparable to that of commercial graphite. The proposed multi-field-assisted low-temperature molten salt roasting technique enables the efficient recovery of high-value graphite resources from LCR, establishing a full-lifecycle recycling strategy tailored for lithium-ion battery applications. Full article

Background/Objectives: Glyphosate-based formulations are globally pervasive pollutants increasingly recognized as potential contributors to antimicrobial resistance (AMR) in environmental microbiomes. Although glyphosate is designed to inhibit plant 5-enolpyruvylshikimate-3-phosphate synthase, it also affects microbial metabolism, stress response, and genetic exchange. This review synthesizes the pathways through which glyphosate, its metabolite aminomethylphosphonic acid (AMPA), and commercial mixtures influence resistance-associated phenotypes and the dissemination of antibiotic resistance (ABR). Methods: A critical synthesis of the literature was conducted to evaluate the mechanistic and ecological interactions between glyphosate exposure and bacterial resistance in soil, aquatic, and host-associated microbiomes. Results: Experimental evidence showed that sublethal glyphosate exposure induced oxidative stress, altered membrane permeability, activated multidrug efflux pumps, and promoted tolerance phenotypes that could modify antibiotic susceptibility. It also enhances mutation rates and horizontal gene transfer processes associated with the emergence of resistance under controlled conditions. At the community level, glyphosate exposure is associated with microbiome restructuring and enrichment of resistance determinants, often without major shifts in overall diversity of the microbiome. These effects have been reported at environmentally relevant concentrations, although the evidence remains largely derived from laboratory and mesocosm studies. Conclusions: Glyphosate acts as both a biochemical modulator of resistance-related phenotypes and an environmental selective pressure that shapes microbial communities. Its widespread use and environmental persistence position it as a context-dependent contributor to the emergence and dissemination of AMR through interacting mechanistic and ecological pathways. Integrating AMR endpoints into pesticide risk assessments and surveillance frameworks is warranted, in addition to expanded field-based validation. Full article

Groundwater plays an indispensable role in daily life. However, with the continuous advancement of industrialization, more attention should be paid to the quality of groundwater and the associated potential health risks in areas surrounding industrial parks. In this study, groundwater samples collected in the city of the Tibetan Plateau during the wet season (WS) and dry season (DS) were analyzed using Piper diagrams, Gibbs diagrams, and correlation analysis. The results elucidated the hydrochemical characteristics, formation mechanisms, and controlling factors of groundwater in the area. Groundwater potability was assessed using the Entropy-weighted Water Quality Index (EWQI) method. In addition, the health risk assessment model was applied to evaluate potential risks for four population groups, with NO₃⁻ and F⁻ selected as representative groundwater pollutants. The findings revealed that groundwater in the study zone was typically moderately alkaline and characterized primarily as soft–fresh and hard–fresh. The groundwater in both seasons mainly exhibited HCO₃–Ca chemical facies. Water–rock interactions involving silicate and carbonate minerals were identified as key processes controlling the hydrochemical composition in both seasons. EWQI results showed that groundwater quality for drinking purposes was excellent in the seasons. Sensitivity analysis further showed that Cl− exerted the greatest influence on the drinking water quality evaluation in both seasons. Health risk assessments revealed that the risks posed by NO₃⁻ and F⁻ to infants, children, adult females, and adult males remained within acceptable limits (with max values of 0.63, 0.39, 0.28, and 0.33 in the WS, and 0.59, 0.36, 0.26, and 0.31 in the DS, respectively). However, infants exhibited greater susceptibility than the other groups across seasons, with a risk index approximately twice that of adults. Overall, the findings contribute valuable insights for the sustainable management and planning of groundwater resources in the study zone. Future research could refine the risk assessment model with localized data and explore mitigation strategies for elevated risks in specific seasons or regions. Full article

Currently, there are no data and studies from Lake Vaya, Burgas city, on the status and quantity of microplastic (MP) particles in fish. This is the first study on the abundance, morphotype, size, polymer type, and color of MP in Gambusia affinis and Liza saliens from the lake. In this study, we also investigated the distribution of MPs in different parts of the fish. Within each morphological group of MPs, three size classes were recognized: 25–100 µm, 100–200 µm, and 200–500 µm. Microplastics were found in all studied fish tissues except for caviar, but in different proportions of pellets, fibers, and fragments. In our study, fibers were the most isolated, followed by irregularly shaped MPs—fragments. Two types of polymers were found—PET and PA. There are currently no studies in Lake Vaya that assess the risk of ingestion of microplastics for fish health and human health. Research shows that almost all aquatic environments worldwide are at risk of MP contamination. Laboratory and field studies highlighted that fish are particularly susceptible to MP ingestion, although freshwater species have been studied less than marine ones. The results of our study suggest that consumption of fish from Lake Vaya may expose citizens to risk. Full article

Previous research has found an association between PM_2.5 exposure and worsening depression; however, studies specifically examining the harmful effects of individual PM_2.5 components are relatively limited. This national survey enrolled individuals aged 45 and older in mainland China, collecting personal data and assessing depression. Depressive symptoms were assessed using the 10-item Center for Epidemiologic Studies Depression Scale (CES-D-10). Monthly exposure to PM_2.5 and its seven components—black carbon (BC), organic matter (OM), nitrate (NO₃⁻), sulfate (SO₄²⁻), ammonium (NH₄⁺), soil particles (SOIL), and sea salt (SS)—was matched to each participant’s residence. Linear mixed-effects models (LMEs) assessed the association between single pollutants and depression score, while weighted quantile sum (WQS) regression examined the effect of mixed exposure and identified the contribution of each component. Modifying effects of social activity and green space were also evaluated. A total of 9725 participants were included. In single-exposure models, each interquartile range (IQR) increase in PM_2.5 (29.18 μg/m³), BC (2.25 μg/m³), OM (7.18 μg/m³), SOIL (6.04 μg/m³), and SS (0.14 μg/m³) was significantly associated with an increase in depression score of 0.90 (95% CI: 0.59, 1.20), 0.71 (95% CI: 0.42, 1.09), 0.94 (95% CI: 0.61, 1.26), 0.51 (95% CI: 0.38, 0.63), and 0.53 (95% CI: 0.33, 0.73) points, respectively. In mixed-exposure models, each IQR increase in the mixture of all components was associated with a 1.104-point rise in depression score (95% CI: 0.901, 1.307), with BC having the largest weight (33.6%), followed by SOIL (28.59%) and SS (25.05%). The harmful effects of PM_2.5 and specific components on depression were lower among those who participated in social activities or lived in areas with higher levels of green space (p < 0.05). These findings suggest that the harmful effects of PM_2.5 on depression may be influenced by its components, and that social activity and green space could reduce the risk of depression associated with PM_2.5 and its components. Full article

Medicinal plants represent important sources of bioactive compounds with beneficial effects on human health. However, many medicinal species are ruderal plants capable of growing in soils with elevated contents of potentially toxic elements (PTEs) such as Cd, Pb, and Zn. In addition to the potential accumulation of PTEs in plant biomass, the response of the plant metabolome—including bioactive substances with beneficial health effects—to elevated PTE levels in plants should also be considered. The potential impact of soil PTEs on the plant metabolome was investigated in three widely used medicinal plants, Taraxacum sp., Achillea millefolium, and Hypericum maculatum, sampled in an area polluted with PTEs. The total soil contents of the PTEs ranged between 7.7 and 65 mg/kg for Cd, 1541 and 3897 mg/kg for Pb, and 245 and 6553 mg/kg for Zn. A qualitative analysis of the whole plant metabolomes of the three plant species indicated close interrelationships between the selected metals and bioactive substances. Subsequently, a model pot experiment was conducted in which Taraxacum sp. plants were cultivated in three soils with stepwise increasing Cd, Pb, and Zn contents, and selected bioactive compounds were quantified. The results showed a decrease in the concentrations of some phenolic compounds in the aboveground parts of Taraxacum sp. grown in extremely polluted soil, supporting the hypothesis that stress induced by PTEs may affect the metabolic pathways of these compounds. In contrast, higher levels of phenolic compounds were observed in Taraxacum sp. roots grown in moderately contaminated soil, suggesting that milder soil contamination may activate defence mechanisms and stimulate phenolic metabolism. However, although the contents of bioactive compounds in plants indicate an improvement of the quality of these medicinal plants, the elevated element contents in the plant biomass can represent a potential risk for consumers. Full article

Microplastics (MPs) are emerging pollutants of global concern, posing significant ecological and human health risks. They are frequently detected in stormwater systems, with urban runoff serving as a major transport pathway into the environment. Green stormwater infrastructure, particularly bioretention systems (BRSs), offers a promising approach to mitigate these risks by filtering and retaining various contaminants. However, the occurrence of MPs in BRSs and their capacity to retain these pollutants remain largely unexplored in the literature, despite being critical for stormwater management and water quality protection. Therefore, this study attempted to examine the occurrence, vertical distribution, and trapping of MPs within a field-installed BRS, potentially emphasizing their role in reducing microplastic (MP) transport. Therefore, field samples were collected at depths of 2, 12, and 24 inches below the surface and processed in the laboratory for MP detection and quantification. The results revealed an average concentration of 1095 particles per kg of dried sediment, with fragments (microplastics shape) accounting for 78.54% of the total MPs. Although no clear vertical distribution pattern was observed, the initial findings showed that MPs were mostly retained at 24 inches, potentially indicating their transport through the media and the retention capacity of a BRS (surface and middle layer) in capturing microplastics from stormwater environments. However, there is no direct evidence to explain the mechanisms driving the observed concentrations at greater depths. The preliminary findings of this study highlight that the concentrations of different sizes of MPs can vary with soil depth in bioretention media. Integrating a BRS into urban stormwater infrastructure likely provides the dual benefits of improved stormwater management and reduced plastic pollution. This study underscores the importance of optimizing bioretention design and media composition to enhance MP trapping from stormwater. Full article