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Search Results (729)

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26 pages, 820 KB  
Systematic Review
Hypofractionation in Unresectable Stage II–III NSCLC: A Systematic Technical Review and Practical Recommendations
by Gabriela Antelo, Miriam Núñez-Fernández, Josep Carreras, Nuria Farre-Bernardo, Paloma Sosa Fajardo, Inmaculada Romero-Palomar, Nuria Rodríguez de Dios and Arturo Navarro-Martin
Cancers 2026, 18(18), 2997; https://doi.org/10.3390/cancers18182997 - 16 Sep 2026
Viewed by 78
Abstract
Background: Concurrent chemoradiotherapy (cCRT) followed by 1 year of consolidation durvalumab remains the standard of care for unresectable stage III non-small cell lung cancer (NSCLC), yet long-term survival is still limited and around 20% of patients present locoregional relapse. Hypofractionation may improve the [...] Read more.
Background: Concurrent chemoradiotherapy (cCRT) followed by 1 year of consolidation durvalumab remains the standard of care for unresectable stage III non-small cell lung cancer (NSCLC), yet long-term survival is still limited and around 20% of patients present locoregional relapse. Hypofractionation may improve the therapeutic ratio by increasing the biologically effective dose (BED), shortening overall treatment time (OTT) and potentially mitigating radiation-induced lymphopenia. Objective: To identify which patients with unresectable stage II–III NSCLC may benefit most from radical-intent hypofractionated radiotherapy (HypoRT), with or without systemic therapy, and to define the technical aspects, contouring margins, and dosimetric requirements necessary for the safe use of hypofractionated schedule. Methods: A systematic search of PubMed, EMBASE, CENTRAL and Web of Science (January 2010–January 2024, English language) was performed following PRISMA principles. Eligible studies included unresectable NSCLC treated with a BED10 > 40 Gy, allowing induction systemic or targeted therapy; reviews were included for context. Records were screened by six independent reviewers. Studies were classified as non-photon vs. photon, and photon studies were further divided into non-concurrent and concurrent strategies. Clinical outcomes (dose, fractionation, biologically effective Dose for alpha/beta:10 (BED10), equivalent dose of 2 Gy/fraction (EQD2), overall treatment time (OTT), follow-up (FU), median progression-free survival (mPFS), median Overall Survival (mOS), local control (LC), grade ≥ 3 toxicity (G3) and technical variables (immobilization, simulation, GTV imaging, CTV/PTV margins, delivery, image-guided radiotherapy (IGRT), organ at risk (OAR) constraints) were extracted. Results: Of 340 records (170 duplicates), 26 studies including stage II–III disease were analyzed (1155 patients): 1 prospective cohort, 5 phase I, 12 phase II, 1 phase III and 2 phase I/II dose-escalation trials, 2 carbon-ion and 3 proton series. Of these, 13 were photon-based studies with contemporary simulation techniques. Two clinically distinct scenarios emerged. Group A (non-concurrent platinum-based strategies; 166 patients with modern 4DCT simulation) showed wide variability, ranging from a simultaneous-integrated-boost regimen to 75 Gy with 0% grade ≥ 3 toxicity and mPFS 40 months to a chemotherapy-driven schedule with 70% grade 4 chemo-related toxicity. Only one phase III trial was identified, reporting a 2-year local control of 85.8%. Group B (concurrent strategies; nine of the 14 platinum-based studies retrieved, namely those using modern simulation techniques) achieved a median BED of 89.7 Gy to the highest dose-volume, median of OS 20 months and toxicity GIII ≥ ranging 10–20%, with a median study-level grade 5 toxicity of 5.5% (range 0–17.8%; 34 fatal events among 431 evaluable patients, 7.9%), rising to 20.8% (11/53) in the most escalated randomized arm and 22.2% (2/9) in the highest dose-escalation cohort; adaptive SABR boost to 70 Gy/15 fr delivered high local control but clinically meaningful fatal toxicity. Fatal toxicity was confined to schedules exceeding BED10 100 Gy delivered to the whole tumor volume with concurrent platinum, whereas an equivalent BED restricted to a metabolically defined subvolume without concurrent chemotherapy produced no grade ≥3 events. Conclusions: Radical-intent hypofractionation is feasible across both unfit and fit unresectable stage II–III NSCLC populations, but the randomized evidence remains scarce and heterogeneous. Benefit appears most consistent when high BED is delivered with strict normal-tissue sparing in carefully selected patients using modern 4DCT-based simulation, IGRT and intensity-modulated delivery. The pattern of fatal toxicity with aggressive concurrent systemic treatments and dose escalation schedules argues for caution and for prospective trials with harmonized minimum technical standards. Full article
(This article belongs to the Special Issue Recent Advances and Emerging Directions in Lung Cancer Radiotherapy)
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17 pages, 3435 KB  
Article
Comparative Optical Response of DNA-Natural and Synthetic Food Colorant Systems
by Ana-Maria Manea-Saghin, Petronela Gheorghe and Jaroslaw Mysliwiec
Polymers 2026, 18(18), 2256; https://doi.org/10.3390/polym18182256 - 16 Sep 2026
Viewed by 61
Abstract
Biopolymers functionalized with chromophores exhibit interesting optical properties with a high potential for applications in photonics. Quinoline yellow (QY), sunset yellow (SY) and riboflavin (RB) are commonly used as colorants in the food industry, which makes them suitable candidates for the development and [...] Read more.
Biopolymers functionalized with chromophores exhibit interesting optical properties with a high potential for applications in photonics. Quinoline yellow (QY), sunset yellow (SY) and riboflavin (RB) are commonly used as colorants in the food industry, which makes them suitable candidates for the development and manufacture of environmentally friendly devices for integrated photonics. The incorporation of these dyes into a deoxyribonucleic acid (DNA) matrix could significantly contribute to enhance the optical response and sensitivity of the obtained composites. This enhancement is mainly due to the interaction between the conjugated π-electrons from the aromatic groups of the chromophores and the DNA matrix. Also, it may influence the appearance of interesting molecular structural arrangements and modify the local electronic environment. The linear optical analysis was performed by UV-Vis, fluorescence and Fourier transform infrared (FTIR) spectroscopies. At the same time, the pump–probe interferometric method was used to study the light-induced refractive index modification. Full article
(This article belongs to the Special Issue Polymer Materials for Environmental Applications)
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15 pages, 2713 KB  
Article
Tunable Terahertz Optical Bistability Enabled by Synergistic Topological Edge States and Weyl Semimetal
by Zhiheng Li, Zean Shen, Liuxin Qian, Zhiwei Zheng and Leyong Jiang
Nanomaterials 2026, 16(18), 1144; https://doi.org/10.3390/nano16181144 - 12 Sep 2026
Viewed by 267
Abstract
Low-threshold optical bistability (OB) holds significant application prospects in various fields. In this work, we theoretically propose a one-dimensional photonic crystal heterostructure incorporating a Weyl semimetal (WSM) layer. The design synergistically combines the local field enhancement associated with topological edge states (TESs) and [...] Read more.
Low-threshold optical bistability (OB) holds significant application prospects in various fields. In this work, we theoretically propose a one-dimensional photonic crystal heterostructure incorporating a Weyl semimetal (WSM) layer. The design synergistically combines the local field enhancement associated with topological edge states (TESs) and the strong intrinsic nonlinearity of WSM. Through parameter optimization, a tunable OB phenomenon with a threshold of 105 V/m for both the incident electric field and the transmitted electric field is achieved in the terahertz regime. Furthermore, key characteristics of the OB, including the switching threshold and hysteresis loop width, can be flexibly manipulated by adjusting parameters such as the angle of incidence, the incident wavelength, and the thickness of the WSM layer. We believe that the proposed scheme may provide useful theoretical guidance for future studies of low-threshold nonlinear phenomena and terahertz photonic functionalities based on WSM. Full article
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35 pages, 8085 KB  
Article
Diagnosing GEDI Canopy Height Errors in Steep Mountainous Forests: Ground Elevation Representation and Geolocation Uncertainty
by Fuqiang Shen, Xiaohai He, Yanchao Gu, Zhengyuan Qin and Xiaohong Wu
Forests 2026, 17(9), 1087; https://doi.org/10.3390/f17091087 - 11 Sep 2026
Viewed by 199
Abstract
Spaceborne LiDAR provides essential observations of forest vertical structure, yet canopy height retrievals remain vulnerable to terrain-related errors in steep mountainous forests, where terrain heterogeneity complicates attribution of error to footprint geolocation and ground elevation representation. To distinguish these effects, we used 1 [...] Read more.
Spaceborne LiDAR provides essential observations of forest vertical structure, yet canopy height retrievals remain vulnerable to terrain-related errors in steep mountainous forests, where terrain heterogeneity complicates attribution of error to footprint geolocation and ground elevation representation. To distinguish these effects, we used 1 m airborne laser scanning (ALS)-derived digital terrain and canopy height models (DTM and CHM) as local references in Jiuzhaigou, China. A 2 × 2 diagnostic design independently varied footprint geolocation and ground reference across four slope classes. For 2102 strictly filtered footprints, geolocation refinement slightly increased RMSE from 13.36 to 13.47 m, whereas median-based ground reference replacement reduced RMSE to 9.98 m, a 25.3% reduction. The GEDI-implied ground was closest to the footprint median below 35° but shifted toward P20–P30 in the steepest terrain. Vertical reference sensitivity showed that the exact ground-diagnostic optimum shifted between P20 and P30, whereas the footprint median consistently minimized corrected-RH98 RMSE against ALS CHM P98. The ATL03 comparison likewise showed substantially improved canopy height agreement when ALS DTM replaced Copernicus DEM as the terrain support input under otherwise identical photon processing. These results identify ground elevation representation, rather than the tested horizontal geolocation refinement, as the dominant terrain-related factor shaping GEDI–ALS canopy height disagreement in steep terrain and show that ground diagnosis and RH98 correction require different terrain-reference choices. Full article
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23 pages, 12995 KB  
Article
Developing the Readout Electronics for a Custom 64 × 64 SPAD Array: From Single-Board Prototyping to FPGA Implementation Toward Stellar Intensity Interferometry
by Álvaro Quintana, Guillermo González-de-Rivera, Sergio López-Buedo and Francisco Prada
Sensors 2026, 26(18), 5757; https://doi.org/10.3390/s26185757 - 10 Sep 2026
Viewed by 484
Abstract
Single-photon avalanche diode (SPAD) arrays enable photon-starved applications, including time-of-flight imaging and stellar intensity interferometry. Their astronomical use remains scarcely explored, as the bottleneck is usually not detection but rather acquisition electronics for high-rate event streams. This work presents a modular, event-driven acquisition [...] Read more.
Single-photon avalanche diode (SPAD) arrays enable photon-starved applications, including time-of-flight imaging and stellar intensity interferometry. Their astronomical use remains scarcely explored, as the bottleneck is usually not detection but rather acquisition electronics for high-rate event streams. This work presents a modular, event-driven acquisition system for a 64 × 64 SPAD array within the La Palma Quantum Interferometer (LPQI) project, repurposing a LiDAR detector for multi-telescope interferometry. Two stages are used: a Raspberry Pi 5 with a custom board for validation, and an AMD Kria KR260 (Zynq UltraScale+ MPSoC) implementing the Address-Event Representation (AER) handshake in hardware at 100 MHz. The system streams AER events without per-event timestamping; sub-nanosecond time-tagging is left for a future stage based on the White Rabbit protocol. Optical bench tests confirmed spatial detection and localization of photons at a measured throughput of up to ≈124 keps under the highest illumination condition tested, and dark-count-rate characterization showed a rate below 10 Hz for most pixels (median: 1.68 Hz at 27.8 °C); raw per-pixel event-count maps further confirmed, for the first time on this array, the expected 2 × 2 spatial pattern of inter-pixel crosstalk from its shared-cathode pixel groups. The results demonstrate the feasibility of repurposing a LiDAR SPAD sensor and establish an acquisition-electronics baseline to aid the development of a timestamped, multi-telescope system for deployment on five telescopes of the Roque de los Muchachos Observatory. Full article
(This article belongs to the Special Issue SPAD-Based Sensors and Techniques for Enhanced Sensing Applications)
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36 pages, 2818 KB  
Review
Defect and Interface Engineering of VO2 for Reconfigurable Nanophotonics
by Ardak Ainabayev, Zinetula Insepov and Kurbangali Tynyshtykbayev
Nanomaterials 2026, 16(18), 1132; https://doi.org/10.3390/nano16181132 - 10 Sep 2026
Viewed by 374
Abstract
Vanadium dioxide (VO2) is a prominent active material for reconfigurable nanophotonics because its reversible metal-insulator transition produces large changes in complex refractive index and electrical conductivity. The usable phase contrast, however, is not an intrinsic constant: it is governed by defect [...] Read more.
Vanadium dioxide (VO2) is a prominent active material for reconfigurable nanophotonics because its reversible metal-insulator transition produces large changes in complex refractive index and electrical conductivity. The usable phase contrast, however, is not an intrinsic constant: it is governed by defect type and location, vanadium valence, oxygen stoichiometry, strain, crystallographic orientation, dimensionality, and the chemical, electrical, optical, and thermal boundary conditions imposed by interfaces. This focused narrative review develops a defect- and interface-centred framework linking VO2 phase physics to device-level optical modulation. Bulk, surface, grain-boundary, and heterointerface defects are distinguished, together with their effects on carriers, V-V bonding, phase stability, optical loss, and cycling reliability. Epitaxial and polycrystalline films, ultrathin layers, and nanostructures are compared across the visible, near-infrared, mid-infrared, and terahertz ranges. Thermal, optical, electrical, electrostatic, electrochemical, ionic, strain, and ferroelectric activation pathways are then compared according to volatility, speed, retention, reversibility, and endurance. Representative free-space metasurfaces, guided-wave modulators, adaptive emitters, and photonic memories are benchmarked separately to avoid mixing incomparable performance definitions. The resulting analysis shows that optical modulation, insertion loss, thermal overhead, ambient stability, and endurance are coupled through the same defect and interface landscape. Progress, therefore, requires coordinated control of phase purity, local chemistry, interface energetics, thermal transport, and architecture-specific performance reporting. Full article
(This article belongs to the Special Issue State of the Art in Semiconductor Nanophotonics)
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20 pages, 3400 KB  
Article
Identification and Expression Analysis of the Formin Gene Family in Neopyropia yezoensis Under Different Environmental Conditions
by Shengqi Ye, Hongxin Ji, Lianxuan Chen, Jingwen Qi and Haihong Chen
Genes 2026, 17(9), 1089; https://doi.org/10.3390/genes17091089 - 10 Sep 2026
Viewed by 217
Abstract
Background/Objectives: Neopyropia yezoensis is an economically important intertidal red alga that frequently experiences fluctuations in temperature, light intensity, and water availability. Formins are key regulators of actin nucleation and cytoskeletal dynamics, but their functions and stress-responsive roles in red algae remain poorly [...] Read more.
Background/Objectives: Neopyropia yezoensis is an economically important intertidal red alga that frequently experiences fluctuations in temperature, light intensity, and water availability. Formins are key regulators of actin nucleation and cytoskeletal dynamics, but their functions and stress-responsive roles in red algae remain poorly understood. This study aimed to systematically identify and characterize the Formin gene family in N. yezoensis and investigate their expression responses to different environmental stresses. Methods: Formin family members were identified from the N. yezoensis genome using HMMER and BLAST (2.17.0) searches based on the conserved FH2 domain, followed by domain validation. Gene structures, conserved motifs, physicochemical properties, predicted subcellular localization, protein structures, chromosomal distribution, phylogenetic relationships, and cis-acting elements in the upstream regions were analyzed. The expression patterns of the identified Formin genes were further examined by qRT-PCR under different temperature (4, 10, and 24 °C), light intensity (20, 60, and 100 μmol photons m−2 s−1), and desiccation/rehydration conditions. Results: Three Formin genes, designated NpyFormin01–03, were identified in N. yezoensis. All three encoded proteins contained the conserved FH2 domain but differed in motif composition, domain architecture, predicted subcellular localization, and structural features. NpyFormin01 contained additional PTEN_C2 and PTP_DSP_cys domains, whereas NpyFormin02 and NpyFormin03 contained only the FH2 domain. Phylogenetic analysis showed that the N. yezoensis Formins clustered with Formins from other red algae. Promoter analysis identified multiple predicted cis-acting elements associated with light, temperature, environmental, and phytohormone responses. Expression analysis revealed distinct responses among the three genes under the tested environmental conditions. Notably, NpyFormin01 was significantly upregulated under high-temperature treatment (24 °C), whereas NpyFormin02 and NpyFormin03 showed no statistically significant expression changes under the tested conditions. Conclusions: This study provides a systematic characterization of the Formin gene family in N. yezoensis. The differences in protein architecture, structural features, promoter cis-acting elements, and environmental-responsive expression patterns suggest potential functional divergence among NpyFormins. In particular, NpyFormin01 represents a potential heat-responsive candidate gene and may contribute to cytoskeletal regulation during environmental stress adaptation in N. yezoensis. These findings provide a basis for further investigation of the molecular functions of Formins in red algae. Full article
(This article belongs to the Section Plant Genetics and Genomics)
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53 pages, 1609 KB  
Article
EDDE-MT-Based Detection-Record Integrity and DV-QKD with Side-Channel Monitoring Using DVQMTC and E-TeLU-Bi-LSTM for Securing CPS
by Vidhya Prakash Rajendran, Deepalakshmi Perumalsamy, Chinnasamy Ponnusamy and Ezhil Kalaimannan
Quantum Rep. 2026, 8(3), 91; https://doi.org/10.3390/quantum8030091 - 7 Sep 2026
Viewed by 224
Abstract
Discrete-Variable Quantum Key Distribution (DV-QKD) provides a mechanism for establishing secret keys between legitimate parties using quantum-state transmission and authenticated classical post-processing. In this work, the underlying quantum layer follows a biased-basis decoy-state BB84 model using phase-randomized weak coherent pulses, while additional implementation-level [...] Read more.
Discrete-Variable Quantum Key Distribution (DV-QKD) provides a mechanism for establishing secret keys between legitimate parties using quantum-state transmission and authenticated classical post-processing. In this work, the underlying quantum layer follows a biased-basis decoy-state BB84 model using phase-randomized weak coherent pulses, while additional implementation-level mechanisms are integrated to support Cyber-Physical System (CPS) communication. Exponential Double Delta Encoding-based Merkle Tree (EDDE-MT) is employed as a receiver-side detection-record integrity mechanism for detecting deletion, insertion, reordering, or modification of records relative to an authenticated committed detection-event batch. It does not establish the completeness of the original TCSPC acquisition, detect records omitted before commitment, detect physical photon loss, or increase the information-theoretic secrecy of the QKD key. Time-Correlated Single Photon Counting (TCSPC) is used for detection-event and timing acquisition, while 2’s Complement Cyclic Redundancy Check-based Low-Density Parity Check (2CCRC-LDPC) supports error reconciliation. Following privacy amplification, the legitimate parties retain matching copies of the distilled QKD key locally. Discrete Variable Quantum Mellin Transform Cryptography (DVQMTC) uses fresh, non-reused segments of this privacy-amplified key for application-layer payload protection; the Mellin-transform component is treated only as implementation-level preprocessing and not as a cryptographic key-generation mechanism. Side-channel monitoring is performed using Gini Cramer’s V Correlation-Stationary Wavelet Transform (GCVC-SWT), Helical Valley-Principal Component Analysis (HV-PCA), and an Entmax-based hyperbolic Tangent exponential Linear Unit-Bidirectional Long Short-Term Memory (E-TeLU-Bi-LSTM) classifier. On the AES-HD benchmark, E-TeLU-Bi-LSTM achieved 99.24% classification accuracy; this value represents benchmark-level classification performance and is not interpreted as experimental validation of physical side-channel protection in a deployed DV-QKD system. Frequency Division Multiple Access (FDMA) and the Halton Quasi-Sequence-Invasive Weed Optimization Algorithm (HQS-IWOA) are further incorporated as classical network-resource segmentation and load-management mechanisms and do not modify the composable QKD security bound. The contribution of the work is therefore positioned as a system-level engineering integration of QKD key establishment, detection-record integrity, reconciliation, application-layer data protection, side-channel monitoring, and network-resource management for CPS. The information-theoretic secrecy claim remains restricted to the underlying finite-key decoy-state BB84 procedure under the stated security assumptions; no new QKD security theorem, formally new cryptographic primitive, or experimentally validated physical quantum communication capability is claimed. Full article
(This article belongs to the Section Quantum Communication and Networks)
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58 pages, 1030 KB  
Review
Toward a Thermodynamic Framework for Dissipative Solitons: From Photonics to Turbulence and Bose–Einstein Condensate Analogies
by Vladimir L. Kalashnikov and Irina T. Sorokina
Appl. Sci. 2026, 16(17), 8895; https://doi.org/10.3390/app16178895 - 7 Sep 2026
Viewed by 181
Abstract
Thermodynamic concepts are increasingly used in nonlinear photonics to describe Rayleigh–Jeans thermalization, optical wave turbulence, condensation, negative-temperature states, and statistical mode locking. We ask how far this reasoning can be extended to localized structures maintained far from equilibrium by gain, loss, dispersion, and [...] Read more.
Thermodynamic concepts are increasingly used in nonlinear photonics to describe Rayleigh–Jeans thermalization, optical wave turbulence, condensation, negative-temperature states, and statistical mode locking. We ask how far this reasoning can be extended to localized structures maintained far from equilibrium by gain, loss, dispersion, and nonlinearity, using strongly chirped dissipative solitons (DSs) of the complex cubic–quintic Ginzburg–Landau equation as a model system. Their internal energy flows and separation of correlation scales connect coherent solitary waves with semi-incoherent wave kinetics, driven-open systems, and Bose–Einstein-condensation analogies. We review thermodynamic-like indicators based on spectral entropy, internal energy, effective temperature, and spectral condensation, and we relate them to dissipative-soliton resonance (DSR), stochastic mode-locking self-start, and redistribution between single- and multipulse attractors. Normal and anomalous group-delay dispersion provide complementary cases. In normal dispersion, DSR is accompanied by spectral localization, increasing scale separation, and growing multipulse accessibility; the statistical degree-count interpretation becomes meaningful only after the two scales separate and still requires ensemble calibration. In anomalous dispersion, the spectrum has extended wings, and noisy calculations reveal finite robust regions inside a larger existence domain, without an analogous thermodynamic turnover along the continuation tested. Thus, the unification is strongest at the level of the adiabatic solution and state-selection diagnostics, not an equilibrium thermodynamics. DSs thereby provide a photonic platform linking nonequilibrium thermodynamics, wave turbulence, driven condensates, and statistical phase-transition concepts. Full article
(This article belongs to the Special Issue New Challenges in Thermodynamics)
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35 pages, 2433 KB  
Article
A Multiscale Mechanistic Framework Linking Infection Dynamics, Oxidative Chemiexcitation, and Ultraweak Photon Emission
by Horace T. Crogman, Gisela Alvarez, Peace U. Clement, Rohan B. Sonawane, Rakshitha Chidananda, Huzaif Khan, Kwame Eshun, Eugene Joseph and Daniel B. Erenso
Biophysica 2026, 6(5), 87; https://doi.org/10.3390/biophysica6050087 - 7 Sep 2026
Viewed by 183
Abstract
Ultraweak photon emission (UPE) provides a noninvasive optical signature of oxidative chemistry, but the relationship between infection-associated reactive oxygen species (ROS) and photon emission remains mechanistically uncertain. Here, we develop a multiscale framework linking pathogen dynamics, immune activation, signaling ROS, emission-relevant oxidative chemistry, [...] Read more.
Ultraweak photon emission (UPE) provides a noninvasive optical signature of oxidative chemistry, but the relationship between infection-associated reactive oxygen species (ROS) and photon emission remains mechanistically uncertain. Here, we develop a multiscale framework linking pathogen dynamics, immune activation, signaling ROS, emission-relevant oxidative chemistry, chemiexcitation-capable intermediates, electronically excited molecular states, and wavelength-resolved UPE. Chemiexcitation is represented as incoherent Lindblad pumping, allowing stochastic oxidative reactions to populate molecular excited states without assuming coherent ROS-driven optical excitation. The model was evaluated using literature-constrained oxidative inputs for healthy, severe COVID-19, and sepsis conditions, together with Latin Hypercube uncertainty propagation, Sobol sensitivity analysis, fixed-ROS counterfactual testing, spectral robustness analysis, and a pathway-level PMA/DPI intervention consistency test. Two admissible oxidative-to-photon mappings produced sharply different quantitative predictions from the same clinical ROS inputs. Under a high-gain structure, 9.01-fold and 13.86-fold oxidative increases produced 42.21-fold and 89.02-fold increases in peak UPE, whereas a saturating structure compressed the same inputs to 1.445-fold and 1.450-fold. Local elasticity remained near 1.7 under the high-gain mapping but declined to 0.011 and 0.005 at the COVID-19 and sepsis inputs under the saturating mapping. At fixed ROS, downstream parameter uncertainty produced more than a 200-fold spread in predicted UPE under the high-gain structure. Sobol analysis identified the saturation scale, emission-relevant oxidative lifetime, and signaling-to-emission conversion as the dominant contributors to output variance. In a pathway-level consistency test, a subset of high-gain realizations reproduced the reported DPI/PMA residual-UPE interval under physically admissible residual oxidative drive, whereas none of the sampled saturating realizations did. The model also predicted a progressive redistribution of spectral intensity toward longer wavelengths with increasing oxidative burden, although absolute spectral centroids remained dependent on the assumed spectral representation and emitter weighting. These results show that current ROS measurements constrain the direction of the UPE response more strongly than its quantitative magnitude and do not identify a unique universal ROS-to-UPE transfer function. Full article
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16 pages, 3971 KB  
Article
External Beam Breast and Chest Wall Re-Irradiation Following Resection of Ipsilateral Breast Cancer Recurrence: Dose–Toxicity Relationships and Long-Term Oncologic Outcomes
by Suman Ghosh, Hany Soliman, Edward Chow, Hanbo Chen, Eric Leung, Irene Karam, Eileen Rakovitch, Amir H. Safavi, Danny Vesprini and Gregory J. Czarnota
Cancers 2026, 18(17), 2878; https://doi.org/10.3390/cancers18172878 - 5 Sep 2026
Viewed by 334
Abstract
Background/Objectives: Breast/chest wall (B/CW) re-irradiation (reRT) is approached cautiously because of concerns regarding late toxicity and uncertain benefit. Contemporary data on mature toxicity and oncologic outcomes after external beam photon reRT are limited. Methods: This retrospective cohort included 113 consecutive patients [...] Read more.
Background/Objectives: Breast/chest wall (B/CW) re-irradiation (reRT) is approached cautiously because of concerns regarding late toxicity and uncertain benefit. Contemporary data on mature toxicity and oncologic outcomes after external beam photon reRT are limited. Methods: This retrospective cohort included 113 consecutive patients who completed reRT after resection of locoregionally recurrent breast cancer between 2010 and 2024. The primary endpoint was cumulative incidence of late grade ≥ 2 CTCAE toxicity, analyzed using competing-risks methods. Secondary endpoints were locoregional recurrence-free survival (LRRFS) and local failure (LF), assessed using Kaplan–Meier, Cox regression, and Fine–Gray modeling. Results: Median age at reRT was 66 years. Most recurrences were early-stage (72.6%) and hormone receptor-positive (68.1%). Median cumulative EQD2 was 94.9 Gy, and 25.7% received IMRT. At 67.1 months’ median follow-up, 5-year cumulative incidences of grade ≥ 2 and grade 3 toxicity were 35.4% (95% CI, 25.6–45.1) and 3.9% (95% CI, 0.1–7.8), respectively. Higher cumulative EQD2 predicted grade ≥ 2 toxicity (SHR, 1.94 per 10 Gy; p < 0.001) and grade 3 toxicity (SHR, 4.32 per 10 Gy; p < 0.001). Longer interval between radiotherapy courses (p = 0.029) and IMRT (SHR, 0.40; p = 0.005) were associated with lower grade ≥ 2 toxicity. Five-year LRRFS was 84.2% (95% CI, 76.7–92.4), and LF was 6.8%. Advanced-stage disease and second or subsequent recurrence predicted inferior LRRFS. Partial B/CW reRT did not compromise disease control in early-stage recurrences. Conclusions: Adjuvant breast and chest wall re-irradiation using external photons achieved durable locoregional control with low rates of severe late toxicity in one of the largest reported cohorts. These findings support individualized curative-intent reRT guided by cumulative dose, technique, and recurrence risk. Full article
(This article belongs to the Section Clinical Research in Cancer)
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20 pages, 1972 KB  
Article
Polyethylenimine/Graphene Oxide Nanocomposite for Lightweight X-Ray Radiation Shielding in Aerospace Applications
by Sabina Botti, Francesca Bonfigli, Flaminia Rondino, Dariush Hampai, Yury Cherepennikov and Sultan Dabagov
Materials 2026, 19(17), 3762; https://doi.org/10.3390/ma19173762 - 4 Sep 2026
Viewed by 230
Abstract
The demand for lightweight, flexible, and lead-free radiation shielding for next-generation extravehicular activity suits and aerospace habitat liners is rapidly intensifying. This study investigates the structural organization and X-ray attenuation performance (10–60 keV) of polyethylenimine/graphene oxide (PEI/GO) composites with GO loadings up to [...] Read more.
The demand for lightweight, flexible, and lead-free radiation shielding for next-generation extravehicular activity suits and aerospace habitat liners is rapidly intensifying. This study investigates the structural organization and X-ray attenuation performance (10–60 keV) of polyethylenimine/graphene oxide (PEI/GO) composites with GO loadings up to 50 wt%. Microstructural evolution was systematically tracked via optical image quantification (dispersion, connectivity, and local mixing indices) correlated with micro-Raman spectral mapping. Raman analysis confirmed a structural transition at 40 wt% GO, driven by a dynamic competition between covalent amine–epoxide/carboxyl functionalization and localized π–π stacking of sp2 domains. X-ray transmission and linear attenuation coefficients were evaluated using a dual approach, coupling experimental X-ray exposures with deterministic NIST XCOM calculations and stochastic Monte Carlo simulations. The results demonstrate that GO significantly amplifies low-energy photoelectric absorption due to its oxygen-rich functionalities. An anomalous thickness-dependent attenuation paradox, which can be explained by accounting for forward-scattered Compton buildup in thick blocks and spatial edge refraction along non-percolating cluster interfaces in thin films, was observed experimentally. These findings provide critical material design rules for advanced, flexible, and wearable photon shields operating without mass penalties. Full article
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14 pages, 2448 KB  
Article
Frequency-Offset-Estimation-Assisted Transformer Neural Equalization for a 4.6 km Optical-Heterodyne RoF–Wireless OFDM Link
by Zhihang Ou, Wen Zhou, Ye Zhou, Jiali Chen, Xin Lu, Hansong Ma, Sicong Xu, Jie Zhang, Hanyu Zhang, Yubin Zhang and Jianjun Yu
Sensors 2026, 26(17), 5615; https://doi.org/10.3390/s26175615 - 3 Sep 2026
Viewed by 402
Abstract
To address the issues of subcarrier orthogonality loss and inter-carrier interference (ICI) caused by carrier frequency offset (CFO), this paper proposes and experimentally validates a frequency offset estimation (FOE)-assisted dual-domain Transformer equalizer within an advanced, high-capacity optical-heterodyne radio-over-fiber (RoF)–wireless orthogonal frequency division multiplexing [...] Read more.
To address the issues of subcarrier orthogonality loss and inter-carrier interference (ICI) caused by carrier frequency offset (CFO), this paper proposes and experimentally validates a frequency offset estimation (FOE)-assisted dual-domain Transformer equalizer within an advanced, high-capacity optical-heterodyne radio-over-fiber (RoF)–wireless orthogonal frequency division multiplexing (OFDM) transmission system. To rigorously test the algorithm’s robustness under extreme physical conditions, the experimental platform integrates offline 16-GBaud signal generation, optical I/Q modulation, dual-optical-tone transport over a single-mode-fiber RoF feeder, remote photonic heterodyne frequency conversion based on a uni-traveling-carrier photodiode (UTC-PD), 4.6 km free-space wireless transmission, and 160-GSa/s ultra-high-speed real-time sampling. In this system, the receiver front-end employs an FOE module to pre-compensate for the dominant global CFO-induced phase rotation; subsequently, a low-complexity, compact local-window Transformer is utilized to perform adaptive residual compensation for local data-dependent impairments—such as residual waveform distortion and residual ICI—in both the time and frequency domains (before and after the Fast Fourier Transform, or FFT). This synergistic architecture, combining a physical model-driven approach with a self-attention mechanism, effectively mitigates the adverse impact of global frequency offset on neural network convergence. Experimental results demonstrate that, under conditions of strictly aligned multiply accumulate (MAC) operation complexity, the dual-domain architecture achieves significantly superior performance—in terms of bit error rate (BER), error vector magnitude (EVM), and constellation quality—compared to traditional linear DSP methods and baseline networks such as DNNs, CNNs, and LSTMs. Operating in 16 GBaud QPSK mode with an input optical power of 0 dBm, the system achieves a BER of 1.89×104, representing performance improvements of approximately 5.98-fold and 1.92-fold over the standalone Transformer and FOE-assisted DNN schemes, respectively. Full article
(This article belongs to the Special Issue Advances in Optical Fiber Sensors and Fiber Lasers)
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50 pages, 14774 KB  
Article
QKD-Secured Industrial Smart-Grid Cyber-Physical Systems: Simulation and Q-MambaKAN Detection of Adaptive Side-Channel Attacks
by Ayoub Alsarhan, Bashar S. Khassawneh, Laith Alzboon, Kholoud Alkayid, Mahmoud AlJamal, Eslam Al Maghayreh, Fiyad Ahmad Alenazi and Hussein Al-Ofeishat
Future Internet 2026, 18(9), 468; https://doi.org/10.3390/fi18090468 - 3 Sep 2026
Viewed by 319
Abstract
The increasing interconnection of smart-grid operational technology, industrial-edge services, and utility information systems creates a critical need for resilient and continuously monitored industrial cyber-physical communication. Although quantum key distribution (QKD) can strengthen session-key establishment for advanced metering infrastructure, distributed energy resources, substation automation, [...] Read more.
The increasing interconnection of smart-grid operational technology, industrial-edge services, and utility information systems creates a critical need for resilient and continuously monitored industrial cyber-physical communication. Although quantum key distribution (QKD) can strengthen session-key establishment for advanced metering infrastructure, distributed energy resources, substation automation, supervisory control, and utility-core services, practical QKD deployments remain vulnerable to implementation-level side-channel attacks that can compromise the cryptographic protection layer without directly targeting conventional network packets. This paper presents a QKD-secured industrial smart-grid cyber-physical system framework for simulating and detecting adaptive side-channel attacks. The proposed 36-node industrial communication architecture integrates AMI devices, DER controllers, PMU and substation automation components, industrial-edge gateways, QKD modules, key-management services, SCADA and utility-core servers, security-operation-center components, and adversarial access points. A 100,000-record cyber-quantum dataset is generated across 12 operating conditions comprising normal communication and 11 adaptive QKD side-channel attacks: detector blinding, time shift, wavelength switching, Trojan-horse probing, photon-number splitting, decoy-state spoofing, RNG bias, calibration manipulation, local-oscillator manipulation, synchronization spoofing, and combined adaptive quantum hacking. Each scenario introduces coupled primary and secondary perturbations across optical, detector, timing, synchronization, randomness, calibration, photon-statistical, leakage, key-generation, encryption, and industrial-network-performance features. To support intelligent industrial security monitoring, the proposed Quantum-aware Mamba–Kolmogorov–Arnold Network (Q-MambaKAN) organizes device, network, QKD, side-channel, encryption, and risk evidence into an ordered cyber-quantum representation processed through selective state-space learning, side-channel attention, nonlinear KAN mapping, adaptive fusion, and multi-task prediction heads. Results show that the QBER increases from 0.071 during normal operation to 0.426 under combined adaptive quantum hacking, while encryption success decreases from 98.1% to 0%. Q-MambaKAN achieves a 99.48% binary detection accuracy, a 99.70% binary F1-score, a 97.60% multiclass macro-F1, and a risk RMSE of 0.021. Full article
(This article belongs to the Special Issue Cyber-Physical Systems in Industrial Communication Systems)
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16 pages, 458 KB  
Article
Gravitational Wave Communication via Correlated Photon Tunneling Events in Optical Fiber Ring Resonators Arising from Hyperentangled Photon Pairs
by Raymond Y. Chiao, Nader Inan and Jay Sharping
AppliedPhys 2026, 2(3), 9; https://doi.org/10.3390/appliedphys2030009 - 1 Sep 2026
Viewed by 216
Abstract
A laboratory Hertz-like gravitational wave communication system (“gravity radio”) is proposed using coherent optical-stress sources in high-Q optical fiber ring-resonator arrays. Hyperentangled photon pairs and coincident tunneling events provide timing, phase, and correlations, while the gravitational source is the local, conserved field-plus-medium [...] Read more.
A laboratory Hertz-like gravitational wave communication system (“gravity radio”) is proposed using coherent optical-stress sources in high-Q optical fiber ring-resonator arrays. Hyperentangled photon pairs and coincident tunneling events provide timing, phase, and correlations, while the gravitational source is the local, conserved field-plus-medium stress-energy tensor generated by phase-locked coherent optical fields. Because the electromagnetic stress tensor is quadratic in the fields, the source can contain both sum-frequency and difference-frequency components. The latter is emphasized because it relaxes the localization, phase-stability, and receiver-transduction requirements. The directed coherent transverse-traceless stress amplitude and receiver equivalent strain noise are derived for a meter-scale transfer test. Full article
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