Search Results (234)

The climate crisis poses profound risks to present and future generations. Nonetheless, the perspectives of children and young people internationally, and more specifically in Brazil, remain underexplored. Based on a multi-discipline literature review on climate anxiety and nature (dis)connectedness, the hypothesis is that the effects and symptoms of increasing (dis)connection with natural environments have short-, medium-, and long-term consequences. Access to natural spaces is a vital response to counteract the negative impacts of climate change. This article discusses findings from a study conducted in urban Brazil with 200 young people aged 12 to 18 years old, with the aim of addressing three research questions from ten questions that comprised the complete survey. The major research questions were as follows: 1. ‘Climate change worries me’: How do you relate to this statement? 2. How does climate change affect you?, and 3. Do you think some young people are more affected by climate change than others? The results show that young people care about and are preoccupied with climate change, especially when they reflect on their futures and the future generations. Although young participants are deeply concerned about climate change and feel its effects them personally in the form of anxiety, fear, and insecurity, they often lack clear pathways for contributing to broader environmental efforts beyond individual actions. These findings highlight an urgent need to foster community-based approaches and enhance education and resources for enlarging and improving youth engagement, especially to rethink the everyday strategies addressing these challenges, and to foster new paradigms of interaction with the natural world based on (re)connection with natural spaces. The correlation between climate anxiety and nature (dis)connection offers an approach that is still little explored, especially concerning children and young people. Full article

This study proposes a computational framework that transforms eye-tracking analysis from statistical description to cognitive structure modeling, aiming to reveal the organizational features embedded in the viewing process. Using the designers’ observation of a traditional Chinese landscape painting as an example, the study draws on the goal-oriented nature of design thinking to suggest that such visual exploration may exhibit latent structural tendencies, reflected in patterns of fixation and transition. Rather than focusing on traditional fixation hotspots, our four-dimensional framework (Region, Relation, Weight, Time) treats viewing behavior as structured cognitive networks. To operationalize this framework, we developed a data-driven computational approach that integrates fixation coordinate transformation, K-means clustering, extremum point detection, and linear interpolation. These techniques identify regions of concentrated visual attention and define their spatial boundaries, allowing for the modeling of inter-regional relationships and cognitive organization among visual areas. An adaptive buffer zone method is further employed to quantify the strength of connections between regions and to delineate potential visual nodes and transition pathways. Three design-trained participants were invited to observe the same painting while performing a think-aloud task, with one participant selected for the detailed demonstration of the analytical process. The framework’s applicability across different viewers was validated through consistent structural patterns observed across all three participants, while simultaneously revealing individual differences in their visual exploration strategies. These findings demonstrate that the proposed framework provides a replicable and generalizable method for systematically analyzing viewing behavior across individuals, enabling rapid identification of both common patterns and individual differences in visual exploration. This approach opens new possibilities for discovering structural organization within visual exploration data and analyzing goal-directed viewing behaviors. Although this study focuses on method demonstration, it proposes a preliminary hypothesis that designers’ gaze structures are significantly more clustered and hierarchically organized than those of novices, providing a foundation for future confirmatory testing. Full article

Molecular crosstalk between the gut microbiome and human diet represent a potential therapeutic avenue requiring further investigation as it can be applied to human health management and treatment. Colon cancer, the third leading cause of cancer mortality, is often linked to the gut microbiome. In vitro and in vivo studies and metagenomic research have revealed alterations in gut microbial flora among diseased individuals. The human diet is connected to these changes in microbial inhabitants related to the pathophysiology underlying colorectal cancer (CRC). Polyphenols are well-studied, naturally occurring plant secondary metabolites recognized for their anti-inflammatory and antioxidant properties. The anticancer activities of these compounds are increasingly reported, offering insights into the administration of these natural molecules for managing various types of cancer and developing novel medications from them. Recent investigations have highlighted the prebiotic-like effects of these compounds on gut microbial dysbiosis and their metabolism concerning colorectal cancer, influencing colon cancer by interfering with multiple signaling pathways. This review will focus on the existing literature regarding the prebiotic potential of dietary polyphenols, and further research in this area would be valuable, as the integration of artificial intelligence (AI) and machine learning (ML) can enable analysis of the connections between unique gut microbiome profiles and other dependent factors such as physiological and genetic variables, paving the way for personalized treatment strategies in gut microbiome-based health management and precision medicine. Full article

Groundwater sustains ecosystems, agriculture, and human consumption; therefore, its interaction with hydrocarbons is an important area of research under the umbrella of environmental science and resource exploration. Naturally occurring or anthropogenically introduced hydrocarbons can significantly impact groundwater through complex geochemical processes such as dissolution, adsorption, biodegradation, and redox reactions and can also affect groundwater chemistry in terms of pH, redox potential, dissolved organic carbon, and trace element concentrations. Accurate determination and identification of hydrocarbon contaminants requires advanced analytical methods like gas chromatography, GC–MS, and fluorescence spectroscopy, complemented with isotopic analysis and microbial tracers, which provide insights into sources of contamination and biodegradation pathways. The presence of hydrocarbons in groundwater is a matter of environmental concern but can also valuable data for petroleum exploration, tracing subsurface reservoirs and seepage pathways. This paper refers to the basic need for geochemical investigations combined with advanced detection techniques for successful regulation of thermal–mineral groundwater quality. This contributes towards successful sustainable hydrocarbon resource exploration and water resource conservation, with emphasis on the relationship between groundwater quality and hydrocarbon exploration. The study points out the significance of continuous observation of thermal mineral waters to identify their connection with the specific hydrocarbons of each study area. Full article

This study explores the genetic regulators of microRNAs (miRNAs) using a set of machine learning models to predict miRNA expression levels from gene expression data. Employing machine learning, we accurately predicted the expression of 353 human miRNAs (R² > 0.5), revealing robust miRNA–gene regulatory relationships. By analyzing the coefficients of these predictive models, we identified genetic regulators for each miRNA and highlighted the multifactorial nature of miRNA regulation. Further network analysis uncovered that miRNAs with higher predictive accuracy are more densely connected to their top predictive genes, reflecting strong regulatory control within miRNA–gene networks. To refine these insights, we filtered the miRNA–gene interaction networks to identify miRNAs specifically associated with enriched pathways, such as synaptic function and cardiovascular processes. From this pathway-centric analysis, we present a curated list of miRNAs and their genetic regulators, pinpointing their activity within distinct biological contexts. Additionally, our study provides a comprehensive set of metrics and coefficients for the genes most predictive of miRNA expression, along with a filtered subnetwork of miRNAs linked to specific pathways and phenotypes. By integrating miRNA expression predictors with network analysis and pathway enrichment, this work advances our understanding of miRNA regulatory mechanisms and their roles across distinct biological systems. Our approach enables researchers to train custom models using TCGA data and predict miRNA expression from gene expression inputs. Full article

Air pollutants are significant environmental factors that contribute to the exacerbation of respiratory, cardiopulmonary, and skin diseases in East Asia, and their impact is based on particle size. Natural products represent a promising and sustainable strategy for reducing the adverse effects of air pollutants on health. Cordyceps spp. have been integral to traditional Chinese medicine. Recently, their fruiting bodies and related supplements have gained popularity. The physiological effects of Cordyceps species are well documented and attributed to their chemical constituents, such as cordycepin, polysaccharides, cordymin, glycoprotein, ergosterol, and other bioactive extracts. Cordyceps supplementation may support lung health and enhance respiratory function. Although further clinical data are necessary, many preclinical studies have found a connection between Cordyceps and improved lung health. In addition, preclinical and clinical studies have indicated that Cordyceps and its derivatives (e.g., Ningxinbao, Corbrin, and Jinshuibao capsules) protect against vascular diseases by modulating key molecular pathways. This review provides insights into the potential of Cordyceps for clinical application in the management of air pollutant-related respiratory and vascular diseases. Full article

To pursue the total decarbonization goal set at 2050, the introduction of hydrogen to replace the usage of fossil fuel in hard-to-abate industrial sectors is crucial. Hydrogen will replace natural gas in hard-to-abate sectors where natural gas is required to make heat necessary for the industrial process. Naturally, all this is worthwhile if hydrogen is produced following a green pathway, meaning that it is connected with renewable sources. In this manuscript, a techno-economic analysis related to a real case scenario is carried out. The real system addressed involves continuous high-temperature industrial furnace operation with a seasonally variable but stable thermal energy demand, representing typical conditions of hard-to-abate industrial processes. Solar photovoltaic panels combined with batteries are used to generate and store electricity that in turn is used to generate green hydrogen. Different scenarios are considered, including mixed natural gas/hydrogen, the seasonal variability of industrial needs, and the variability of solar production. The economic aspects considered include the usage of anion exchange membrane water electrolyzers (AEMWEs) to produce green hydrogen, the improvement in efficiency during operations (operational costs, OPEX), and the decrease in the AEMWE cost (Capital expenditures, CAPEX) that occur over time. The study shows that the hydrogen production cost could decrease from 12.6 EUR kg⁻¹ in 2024 to 9.7 EUR kg⁻¹ in 2030, with further reduction to 8.7 EUR kg⁻¹ achievable through seasonal blending strategies. CO₂ emissions are significantly reduced through partial displacement of natural gas with green hydrogen, highlighting the environmental potential of the system. Full article

Changes in cell signaling pathways, which in normal conditions determine the maintenance of cell homeostasis and the correctness of its basic processes, may cause the transformation of a normal cell into a cancer cell. Alterations in cellular metabolism leading to oncogenesis are considered to be a hallmark of cancer cells. Therefore, a thorough understanding of cellular enzymes affecting metabolism and respiration, as well as intracellular pathways connected with them, seems crucial. These changes may be both prognostic and predictive factors, especially in terms of using molecularly targeted therapies. Aberrations in the pathways responsible for cell growth and angiogenesis are considered particularly important in the process of oncogenesis. Gliomas are the most common primary malignant tumors of the brain. The most important molecular disorders determining their particularly malignant nature are aberrations in the pathways responsible for cell growth and angiogenesis, such as the PI3K/Akt or RAS/MAPK/ERK signaling pathway, as well as excessive activity of enzymes, like hexokinases, which play a key role in glycolysis, autophagy, and apoptosis. The multitude of alterations detected in glioma cells, high heterogeneity, and the immunosuppressive environment within the tumor are the main features causing failures in the attempts to implement modern therapies. Full article

Diffuse agricultural pollution is a leading contributor to surface water degradation, particularly in regions undergoing rapid land use change and agricultural intensification. In many developing countries, conventional assessment approaches fall short of capturing the spatial complexity and cumulative nature of multiple environmental drivers that influence surface water vulnerability. This study addresses this gap by introducing the Integral Index of Vulnerability to Diffuse Contamination (IIVDC), a spatially explicit, multi-criteria framework that combines the Analytical Hierarchy Process (AHP) with Geographic Information Systems (GIS). The IIVDC integrates six key indicators—slope, soil erodibility, land use, runoff potential, hydrological connectivity, and observed water quality—weighted through expert elicitation and mapped at high spatial resolution. The methodology was applied to the Guachal River watershed in Valle del Cauca, Colombia, where agricultural pressures are pronounced. Results indicate that 33.0% of the watershed exhibits high vulnerability and 4.3% very high vulnerability, with critical zones aligned with steep slopes, limited vegetation cover, and strong hydrological connectivity to cultivated areas. By accounting for both biophysical attributes and pollutant transport pathways, the IIVDC offers a replicable tool for prioritizing land management interventions. Beyond its technical application, the IIVDC contributes to sustainability by enabling evidence-based decision-making for water resource protection and land use planning. It supports integrated, spatially targeted actions that can reduce long-term contamination risks, guide sustainable agricultural practices, and improve institutional capacity for watershed governance. The approach is particularly suited for contexts where data are limited but spatial planning is essential. Future refinement should consider dynamic water quality monitoring and validation across contrasting hydro-climatic regions to enhance transferability. Full article

This review covers preclinical studies of stilbene derivative compounds (both natural and synthetic) with potential preventive and therapeutic effects against Alzheimer’s disease (AD). AD is a worldwide neurodegenerative disease characterized by the destruction of nerve cells in the brain and the loss of cognitive function due to aging. Stilbenes are a unique class of natural phenolic compounds distinguished by a C6-C2-C6 (1,2-diphenylethylene) structure and two aromatic rings connected by an ethylene bridge. Stilbenes’ distinct features make them an intriguing subject for pharmacological research and development. Several preclinical studies have suggested that stilbenes may have neuroprotective effects by reducing Aβ generation and oligomerization, enhancing Aβ clearance, and regulating tau neuropathology through the prevention of aberrant tau phosphorylation and aggregation, as well as scavenging reactive oxygen species. Synthetic stilbene derivatives also target multiple pathways involved in neuroprotection and have demonstrated promising biological activity in vitro. However, some properties of stilbenes, such as sensitivity to physiological conditions, low solubility, poor permeability, instability, and low bioavailability, limit their usefulness in clinical applications. To address this issue, current investigations have developed new drug delivery systems based on stilbene derivative molecules. This review aims to shed light on the development of next-generation treatment strategies by examining in detail the role of stilbenes in Alzheimer’s pathophysiology and their therapeutic potential. Full article

Background: Induced after-death communication (IADC) therapy is an emerging approach for addressing grief-related distress, particularly in individuals experiencing complicated grief (CG). Developed from eye movement desensitization and reprocessing (EMDR), IADC therapy aims to change the meanings with which loss is read and to transform acute grief into integrated grief. While spontaneous after-death communications (ADCs) have been widely reported across different cultures, IADC therapy provides a structured procedure for inducing a state of mind in which such experiences can spontaneously arise and develop. Methods: This study employed a prospective observational cohort design with a retrospective analysis, comparing the effectiveness of IADC therapy (experimental group, n = 42) to standard grief interventions combining talk therapy and EMDR (control group, n = 43). Participants completed standardized measures, including the Inventory of Complicated Grief (ICG) and the IADC Grief Questionnaire (IADC-GQ), at pre-treatment (T1), post-treatment (T2), and six-month follow-up (T3). Additional analyses explored the role of spirituality, religious affiliation, and therapist characteristics in grief processing. Results: IADC therapy led to a significantly greater reduction in grief intensity (ICG scores) immediately after the intervention and at the six-month follow-up compared to the control group. The experimental group also showed a more pronounced decrease in distress symptoms (CS scores) and higher ratings of therapeutic satisfaction. Furthermore, participants in the experimental group exhibited a significantly greater increase in their continuing bond (CB) scores, suggesting a more adaptive connection with the deceased. Additional analyses examined therapist characteristics, treatment-related factors, and the nature of ADC experiences, which are further explored in the discussion. Conclusions: These findings highlight the clinical utility of IADC therapy as a brief and cost-effective grief intervention, offering comparable or superior outcomes to traditional grief therapies. The results suggest that recognizing and integrating spontaneous ADC experiences into grief therapy may provide a valuable therapeutic pathway. Future research should further explore the long-term effects, cultural variations, and therapist characteristics to optimize the integration of IADC therapy into mainstream clinical practice. Full article

Background/Objectives: Growth in the aging world population is accompanied by an increase in comorbidities, profoundly impacting the quality of life of older people. This development has motivated a large effort to investigate the mechanisms underlying aging and the search for countermeasures. The most investigated strategies envisage the control of diet and physical exercise, which exploit both common and distinct mechanisms to promote health. Since the application of nutritional and exercise protocols to aged persons introduces several issues due to their disabled state, some strategies have been developed. The nutritional approach exploits a wide range of compounds, including calorie restriction mimetics, supplements, antioxidants, and others. In the context of exercise, in recent years, molecules able to provide similar effects to exercise, the so-called exercise mimetics, have been developed. Methods: To have a better perspective on exercise mimetics and their connection with nutrition, we performed a systematic search of the PubMed and Scopus databases using the term “exercise mimetics”. Results: In total, 97 research articles were selected and discussed. The present review provides evidence of the presence of multiple exercise-mimetic compounds and physical strategies that can target metabolic pathways, oxidative stress defense mechanisms, or myokine modulation. Conclusions: Interestingly, this review highlights that an important number of exercise mimetics are represented by products of natural origin and supplements assimilable with diet. This evidence provides a further link between exercise and nutrition and confers a central role on nutrition in the context of exercise mimetics. Full article

Urban environments have incorporated sustainable development into their planning by designing more green spaces. Access to urban green space is the key to the progress of urban sustainability, not only environmentally and ecologically but also socially. Research on social sustainability in parks can be achieved through the inclusive design of park settings that encourage diverse social activities. However, previous research rarely considers how park settings can foster social sustainability for young people. Within this context, this paper employs a qualitative research approach to explore young people’s preferences and engagement with parks through art-based and visual methods to understand how they interact with parks in the context of social sustainability. The visual survey, comprising 32 park scene photos, was administered to 192 youth (ages 9–17) in the Moreton Bay Region, Queensland, Australia. These photos captured four park features: play areas and playgrounds; informal and open areas; formal spaces and pathways; and sports spaces. The findings show that young people like park environments with a balance of physical activity, socialisation, and connection to natural areas. Playgrounds were selected for their active play areas, and open spaces were selected for their social and leisure possibilities. Formal pathways, particularly those connected to natural areas, were selected for their quiet and socialising potential, and sports areas, especially those with equipment, were less preferred due to their solitary nature. The findings highlight the importance of designing parks that promote social sustainability through fostering inclusivity and social cohesion. Such insights inform urban planning policies for making public spaces to meet diverse social needs and support social interactions. Full article

Coastal traditional rural settlements face increasing challenges from human activities and natural disasters driven by global climate change and rapid urbanization. Ensuring their spatial stability is essential for ecological security, economic development, and social sustainability. This study addresses the lack of unified methodologies for assessing the resilience of regional traditional village clusters by proposing a “network construction–spatial simulation–resilience assessment” framework based on complex network theory. Using the Haicao housing village cluster in Rongcheng City, China, as a case study, a spatial network model was constructed, and resilience was evaluated under both current and future scenarios using eight resilience indicators. The results show that the current spatial network structure exhibits clustering with weak interconnections among subgroups. Key nodes significantly influence network metrics, resulting in low overall resilience. In future scenarios, protective measures targeting the top 15% of villages with high development potential enhanced social connections, reduced reliance on key nodes, and improved network resilience. This study provides a quantitative method for assessing the resilience of traditional village clusters and identifies critical pathways and nodes to optimize regional spatial structures. The findings offer new perspectives for guiding the preservation and sustainable development of traditional villages. Full article

Lycopene (carotenoid) is a natural pigment with strong antioxidant properties. The taproots of red carrots (Daucus carota L.) exhibit red coloration due to the presence of high levels of lycopene. However, the candidate genes responsible for regulating lycopene accumulation in red carrots have yet to be identified. In this study, the variations in carotenoid content were assessed at five different stages of taproot development. The results showed a rapid accumulation of lycopene in the taproots between 45 and 60 days after sowing, peaking at its highest level by 75 days. Weighted Gene Co-expression Network Analysis (WGCNA) was used to construct co-expression modules associated with lycopene accumulation. Notably, two of the identified modules (red and mediumpurple3) exhibited significant correlations with lycopene content. A total of 24 differentially expressed genes (DEGs) were enriched by both Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses, and one carotenoid pathway gene was only enriched by KEGG analysis. Among these genes, five genes associated with photosynthesis (DCAR_016944 [DcCHL27], DCAR_021505 [DcFNR2], DCAR_000568 [DcPSB28], DCAR_030558 [DcBPG1], and DCAR_030562 [DcBPG1]) and one carotenoid pathway gene (DCAR_013459 [DcCRTISO-1]) were highly connected hub genes. These six genes were significantly up-regulated at 60 and 75 days after sowing, when the taproots accumulated high lycopene content, and were identified as candidate genes. These findings contribute valuable insights into the molecular mechanisms underlying the modulation of lycopene. Full article