Search Results (4,286)

Background: Radspherin^® is a novel α-emitting radiopharmaceutical administered intraperitoneally following complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) for peritoneal metastases. It delivers short-range radiation aimed at eliminating residual microscopic disease. This qualitative study explored how participants with colorectal cancer experienced participating in an early-phase clinical trial involving CRS-HIPEC followed by Radspherin^®. Materials and Methods: Semi-structured interviews were conducted with ten participants enrolled in a phase 1/2a trial involving CRS-HIPEC and intraperitoneal Radspherin^®. The analysis was guided by a phenomenological and interpretive approach using reflexive thematic analysis. Results: Participants expressed a strong sense of motivation and hope tied specifically to receiving Radspherin^®, which they perceived as an opportunity to improve their prognosis. Many also viewed participation as a contribution to future cancer research. None attributed complications or side effects to Radspherin^®. Clear and supportive verbal communication from healthcare professionals was highly valued, while the written information was described as overwhelming. Despite fears of recurrence, most participants remained optimistic about regaining a meaningful life. While experiences with Radspherin^® were largely positive, participants also described pain, fatigue, and prolonged recovery related to CRS-HIPEC, including ongoing functional and psychosocial challenges. Conclusions: Participants associated Radspherin^® with hope and a therapeutic benefit but did not link it to their adverse events. Their willingness to participate in experimental treatment was shaped by trust in clinicians, clear communication, and a desire for extended survival. However, the burden of CRS-HIPEC-related side effects underscores the importance of tailored follow-up and support. Full article

The integration of omics technologies, including genomics, proteomics, metabolomics, and microbiomics, has transformed sports science, particularly soccer, by providing new opportunities to optimize player performance, reduce injury risk, and enhance recovery. This systematic literature review was conducted in accordance with PRISMA 2020 guidelines and structured using the PICOS/PECOS framework. Comprehensive searches were performed in PubMed, Scopus, and Web of Science up to August 2025. Eligible studies were peer-reviewed original research involving professional or elite soccer players that applied at least one omics approach to outcomes related to performance, health, recovery, or injury prevention. Reviews, conference abstracts, editorials, and studies not involving soccer or omics technologies were excluded. A total of 139 studies met the inclusion criteria. Across the included studies, a total of 19,449 participants were analyzed. Genomic investigations identified numerous single-nucleotide polymorphisms (SNPs) spanning key biological pathways. Cardiovascular and vascular genes (e.g., ACE, AGT, NOS3, VEGF, ADRA2A, ADRB1–3) were associated with endurance, cardiovascular regulation, and recovery. Genes related to muscle structure, metabolism, and hypertrophy (e.g., ACTN3, CKM, MLCK, TRIM63, TTN-AS1, HIF1A, MSTN, MCT1, AMPD1) were linked to sprint performance, metabolic efficiency, and muscle injury susceptibility. Neurotransmission-related genes (BDNF, COMT, DRD1–3, DBH, SLC6A4, HTR2A, APOE) influenced motivation, fatigue, cognitive performance, and brain injury recovery. Connective tissue and extracellular matrix genes (COL1A1, COL1A2, COL2A1, COL5A1, COL12A1, COL22A1, ELN, EMILIN1, TNC, MMP3, GEFT, LIF, HGF) were implicated in ligament, tendon, and muscle injury risk. Energy metabolism and mitochondrial function genes (PPARA, PPARG, PPARD, PPARGC1A, UCP1–3, FTO, TFAM) shaped endurance capacity, substrate utilization, and body composition. Oxidative stress and detoxification pathways (GSTM1, GSTP1, GSTT1, NRF2) influenced recovery and resilience, while bone-related variants (VDR, P2RX7, RANK/RANKL/OPG) were associated with bone density and remodeling. Beyond genomics, proteomics identified markers of muscle damage and repair, metabolomics characterized fatigue- and energy-related signatures, and microbiomics revealed links between gut microbial diversity, recovery, and physiological resilience. Evidence from omics research in soccer supports the potential for individualized approaches to training, nutrition, recovery, and injury prevention. By integrating genomics, proteomics, metabolomics, and microbiomics data, clubs and sports practitioners may design precision strategies tailored to each player’s biological profile. Future research should expand on multi-omics integration, explore gene–environment interactions, and improve representation across sexes, age groups, and competitive levels to advance precision sports medicine in soccer. Full article

Employer-funded education and training (EFET) has gained increasing attention as a strategic human resource practice for developing human capital and enhancing organizational performance. However, empirical evidence on its effectiveness remains limited in emerging economies, particularly within the Kingdom of Saudi Arabia (KSA), where workforce localization and human capital development are central to Vision 2030. This study examines the associations between EFET participation and three key employee outcomes: motivation, retention intention, and productivity. Using a quantitative research design, data were collected from 200 employees and managers across multiple sectors in KSA through a structured questionnaire. Structural Equation Modeling (SEM) was employed to test the hypothesized relationships while controlling for gender, age, sector, and years of experience. The results indicate that EFET participation is positively and significantly associated with employee motivation, retention intention, and self-reported productivity, with the strongest association observed for retention intention. Model fit indices demonstrate an excellent overall fit, supporting the proposed model’s robustness. By integrating Human Capital Theory with empirical evidence from the Saudi context, this study contributes to the literature by extending understanding of how employer-funded education functions within a non-Western labor market. The findings offer practical implications for organizations and policymakers seeking to optimize education and training investments in support of sustainable workforce development and Vision 2030 objectives. Full article

Grounded in the circumplex model, this study examined how need-thwarting teaching styles, control and chaos, are combined by Physical Education teachers (as perceived by students) and how these combinations differ in relation to students’ basic psychological needs and motivational outcomes within (experiences and perceived learning) and outside (intention to be physically active) the Physical Education context. A total of 431 Spanish secondary school students (M_age = 14.92; 53% girls) participated. Latent profile analysis identified three profiles: (1) high control—moderate chaos (35%), (2) moderate control—high chaos (9%), and (3) high demanding—low chaos (56%). Mean comparisons revealed that students in the “high demanding—low chaos” profile reported the most adaptive outcomes, including greater autonomy and competence satisfaction, more positive Physical Education experiences, higher perceived learning, and stronger intentions to be physically active. Conversely, the “moderate control—high chaos” profile was linked to the most maladaptive outcomes, characterized by greater basic psychological needs frustration and poorer experiences, learning, and physical activity intentions. The “high control—moderate chaos” profile yielded intermediate results. Overall, findings indicate that chaotic teaching, especially in its abandoning form, was associated with the worst quality of students’ motivation, while a demanding approach may be comparatively less harmful but still detrimental. Teacher training should therefore reduce controlling and chaotic practices and foster autonomy support and structure. Full article

Cultivating a green innovation-oriented work climate exerts a positive effect on employees’ participation in green knowledge sharing and other co-creation behaviors. Previous studies analyzed the influential factors of green value co-creation from the perspective of green motivation and green dynamic capabilities, but there is a lack of research on the antecedents of green value co-creation from the perspective of green innovation climate. Therefore, based on the social information processing theory, this paper make an in-depth research on the impact mechanism of green innovation climate on employee green value co-creation, through perception of corporate social responsibility and employees’ sense of belonging. A questionnaire survey was conducted on Chinese enterprises implementing green innovation, and 337 valid questionnaires were collected. The effect mechanism of green innovation climate on employees’ green value co-creation was analyzed by the hierarchical regression analysis method. Process regression analysis was used to explore the moderating effect of inclusive leadership. The result of the research shows that green innovation climate has a significant relation to employees’ sense of belonging, perception of corporate social responsibility and employees’ sense of belonging. Perception of corporate social responsibility and employees’ sense of belonging have mediating effects on the relations between green innovation climate and employees’ green value co-creation. Inclusive leadership can moderate the relationship between perception of corporate social responsibility and employees’ green value co-creation. In theory, from the perspectives of green innovation climate and inclusive leadership, it further enriches the research on the driving factors of green value co-creation. In practice, It provides a theoretical reference for enterprises to utilize the strategy of green innovation climate and inclusive leadership to promote green value co-creation of enterprises effectively. Full article

Migration through Central America continues to rise, yet limited research examines how people make migration decisions, especially among those traveling in transit. This study addresses that gap by analyzing the motivations of migrants passing through Casa del Migrante San José in Ocotepeque, Honduras, to examine how long-term pressures interact with immediate triggers during migration. A mixed-methods approach was used, integrating two data sources: 3934 registration records from the Human Mobility Pastoral database (2021–2022) and 75 semi-structured interviews conducted in December 2022. The Push-Pull Plus (PPP) framework was applied to interpret how persistent conditions, immediate triggers, and available support networks influence decisions to migrate. Quantitative results show a marked increase in arrivals during 2022, especially among Venezuelan migrants, with a peak in October following a U.S. policy announcement. Most participants were men aged 21–40 with incomplete secondary education, and economic hardship was the most frequently cited reason for leaving. However, interviews indicate that financial motives were often intertwined with insecurity, family obligations, and unexpected opportunities to travel. Overall, the findings suggest that migration decisions are complex, dynamic, and timing-sensitive, underscoring the need for policies that address the root causes while providing support for migrants in transit. Full article

While multi-view visualization systems are widely used for mining vehicle teleoperation, they often impose high cognitive load and restrict operator attention. To explore a more efficient alternative, this study evaluated a merged-view interface that integrates multiple camera perspectives into a single coherent display. In a controlled experiment, 35 participants navigated a teleoperated robot along a 50 m lab-scale path representative of an underground mine under both multi-view and merged-view conditions. Task performance and eye-tracking data—including completion time, path adherence, and speed-limit violations—were collected for comparison. The merged-view system enabled 6% faster completion times, 21% higher path adherence, and 28% fewer speed-limit violations. Eye-tracking metrics indicated more efficient and distributed attention: blink rate decreased by 29%, fixation duration shortened by 18%, saccade amplitude increased by 11%, and normalized gaze-transition entropy rose by 14%, reflecting broader and more adaptive scanning. NASA-TLX scores further showed a 27% reduction in perceived workload. Regression-based sensitivity analysis revealed that gaze entropy was the strongest predictor of efficiency in the multi-view condition, while fixation duration dominated under merged-view visualization. For path adherence, blink rate was most influential in the multi-view setup, whereas fixation duration became key in merged-view operation. Overall, the results indicated that merged-view visualization improved visual attention distribution and reduced cognitive tunneling indicators in a controlled laboratory teleoperation task, offering early-stage, interface-level insights motivated by mining-relevant teleoperation challenges. Full article

Background/Objective: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have received widespread attention as effective obesity treatments. However, limited research has examined the perspectives of patients contemplating GLP-1RAs. This study explored perceptions, motivations, and barriers among individuals considering GLP-1RA therapy for obesity treatment, with the goal of informing patient-centered care and enhancing clinician engagement. Methods: Adults completed surveys and interviews between June and November 2025. In this pragmatic mixed-methods study, both survey and interview questions explored perceived benefits, barriers, and decision-making processes. Qualitative data, describing themes based on the Health Belief Model, were analyzed using Dedoose (version 9.0.107), and quantitative data were analyzed using SAS (version 9.4). Participant characteristics included marital status, income, educational attainment, employment status, insurance status, age, race/ethnicity, and sex. Anticipated length on GLP-1RA medication and selected self-reported health conditions (depression, anxiety, hypertension, heart disease, back pain, joint pain), reported physical activity level, and perceived weight loss competency were also recorded. Results: Among the 31 non-diabetic participants who were considering GLP-1RA medication for weight loss, cost emerged as the most significant barrier. Life course events, particularly (peri)menopause among women over 44, were commonly cited as contributors to weight gain. Participants expressed uncertainty about eligibility, long-term safety, and treatment expectations. Communication gaps were evident, as few participants initiated discussions and clinician outreach was rare, reflecting limited awareness and discomfort around the topic. Conclusions: Findings highlight that individuals considering GLP-1RA therapy face multifaceted emotional, financial, and informational barriers. Proactive, empathetic clinician engagement, through validation of prior efforts, clear communication of risks and benefits, and correction of misconceptions, can support informed decision-making and align treatment with patient goals. Full article

The TEAPOTS project aims to meet farmers’ waste management needs by converting agricultural waste into renewable energy and, in parallel, plant biostimulants. Surveys conducted in Germany, Greece, and Italy identified farmers’ waste management practices and their willingness to participate in the TEAPOTS Integrated Solution (TIS). Results show general interest in providing waste to TIS owners. Financial returns and soil improvement are key motivators, with the logistics of waste collection and transfer emerging as major challenges. The study highlights the potential of TIS while emphasizing the need for logistics solutions and enhanced pro-environmental attitudes. Full article

Medical students experience fluctuations in their motivation, influenced by various factors, including curricular rigor, mental health, and institutional factors. Based on Self-Determination Theory (SDT) and the Four Pillars of Academic Engagement (HPEE), this study, conducted at a private Mexican university, examined motivational variation according to academic year, curricular impact, gender differences, and its relationship with mental health. Methods: A quantitative, cross-sectional, descriptive study was conducted using qualitative tools for contextualization (n = 1326). Mann–Whitney U tests, Kruskal–Wallis tests, logistic regression, and psychological network analysis were performed. Results: Motivation showed cross-sectional variation: high in preclinical years 1 and 2, decreasing in clinical years 3 and 4 (p < 0.001), and rebounding in year 6. The reformed curriculum (elective subjects, student-centered active learning) resulted in greater motivation (OR = 10.68, p < 0.001). Women tended to have slightly higher motivation (p = 0.050), higher grade point averages (p < 0.001), but also greater stress (p < 0.001). Network analysis revealed that intrinsic achievement (centrality = 1.11) and curiosity about knowledge (predictability = 84.5%) are the main drivers, while demotivation was linked to the later years. The qualitative part of the study showed altruism/curiosity as the main motivators; mistreatment/workload (demotivators). Conclusions: Motivation is context-sensitive, peaks in the preclinical stage, and recovers with autonomy but is vulnerable during clinical immersion. Autonomy in course selection, active student-centered pedagogies, and gender-sensitive support foster sustained participation. The centrality of intrinsic factors in the network highlights that achievement motivation and knowledge are general and independent motivators. Qualitative data reveal systemic barriers. Stage-specific interventions, such as mentoring, student support programs, and reporting mistreatment, can be crucial for strengthening resilience and performance. Longitudinal and multi-institutional studies are needed to validate the causality and generalizability of this study. Full article

The article presents an analysis of the mechanisms used by a vocational high school in Bulgaria to develop dual training and implement it sustainably. It focuses on the school management’s leadership role in the network of different stakeholders, demonstrating the importance of this aspect in the entire process of developing dual education. Apart from the case analysis of the Bulgarian vocational high school’s successful implementation of dual learning, the research strategy includes examining regulatory documents, evaluation reports and publications in media and by companies, as well as analyzing the attitudes among key stakeholders. An overview of the challenges facing dual education in Bulgaria is also provided. Based on the case study findings, the factors supporting the implementation and sustainability of the dual system have been identified. We conclude that the long-term development of the dual education model depends on the understanding that the formation of professional skills is a dynamic process, requiring attention to the needs of the local environment, adaptability to current changes and active participation by all stakeholders. The role of school leadership—with regard to both its motivation and activity—has proven to be essential, and therefore it should not be overlooked when creating state incentives to support dual training. Full article

(1) Background/Purpose: Talent management research has typically focused on early-career entrants or high-potential employees, leaving mid-career professionals underexplored despite their pivotal role in organisational continuity and leadership pipelines. This study examines whether the principles of Conservation of Resources (COR) theory apply to careers, testing whether career resources predict objective and subjective career success, and whether gender differences emerge. (2) Study Design/Methodology/Approach: A three-wave survey of 543 individuals employed in the United Kingdom (UK) (mean age 39) was analysed using Latent Growth Modelling and hierarchical regression to capture the temporal dynamics of career resources and their links to success. (3) Findings: Subjective career success declined overall, but increased among participants with high human capital, environmental resources, career self-management behaviours, and baseline motivation. Gender differences were found: human capital and self-management were stronger predictors for men, while environmental resources were more important for women. Objective success was predicted by human capital only for women, while private-sector employment and subjective success were the strongest predictors for men. (4) Originality/Value: Our unique contribution advances understanding of mid-career dynamics among women and men, highlighting critical implications for talent management. Some, but not all, predictions of COR theory are supported. Women and men experience the benefits of resources differently. Whilst career resources were critical for career success, caring responsibilities were not, irrespective of gender. Organisations must recognise that subjective career success needs resources to sustain it and move beyond one-size-fits-all approaches by tailoring development, mobility, and support systems to gendered and career-stage-specific needs. Full article

Background/Objectives: The present study aimed to examine the associations among achievement motivation, meaning in life, and well-being among video game players and to investigate differences between players with approach- and avoidance-oriented motivations. Methods: The sample consisted of 296 university students who reported playing video games (192 men and 104 women), aged 18 to 35 years (M = 22.62; SD = 2.64). Participants completed a battery of self-report measures, including the Achievement Goal Questionnaire, the Meaning in Life Questionnaire, and the WHO-5 Well-Being Index, administered anonymously. Results: Mediation analyses revealed that meaning in life was a significant mediator in the relationship between approach-oriented mastery goals and well-being (Ind = 0.07; 95% CI [0.02, 0.12]). However, no significant mediation effect was found for approach-oriented performance goals (Ind = 0.04; 95% CI [−0.01, 0.09]). Independent-samples t-tests indicated that participants with approach-oriented motivations reported significantly higher levels of meaning in life (t(294) = 4.44; p < 0.001), presence of meaning (t(294) = 5.74; p < 0.001), and well-being (t(294) = 5.52; p < 0.001) compared to those with avoidance-oriented motivations. Conclusions: The findings suggest that approach-oriented achievement motivations among players are positively associated with meaning in life and are indirectly associated with higher well-being, whereas avoidance-oriented motivations are associated with lower levels of well-being. These results carry potential implications for game design, education, and psychotherapy. Full article

Background/Objectives: Mild Cognitive Impairment (MCI) is a transitional stage between normal aging and early dementia, affecting up to 20% of older adults. Sleep disturbances, particularly insomnia, affect around 60% of individuals with MCI, contributing to declines in cognitive and physical function. Although Cognitive Behavioral Therapy for Insomnia (CBT-I) is an evidence-based non-pharmacological treatment, few studies have adapted it for individuals with MCI. This pilot study developed and evaluated Slumber, a clinician-supported mobile CBT-I app tailored for older adults with MCI and insomnia. Methods: The study had three aims: (1) to develop the app for delivering CBT-I to individuals with MCI; (2) to evaluate its usability and refine smart messaging prompts; and (3) to assess the feasibility of outcome measurement while detecting exploratory signals of change through a 6-week pilot trial. N = 19 participants completed the trial. Results: A significant reduction in insomnia severity was observed (mean difference = −2.06; p = 0.0131), while changes in cognitive and physical functioning were not statistically significant. Participants reported high satisfaction with the app’s tracking features and motivational reminders, though some noted technical challenges with presenting and interpreting sleep analysis charts. Conclusions: Findings support the usability of the Slumber app and the feasibility of outcome measurement in this population. The observed improvement in sleep quality provides an initial signal of promise. Future studies should address user feedback, enhance technical features, and evaluate clinical effectiveness in a larger randomized trial. Full article

This study aimed to test the factorial structure of the Eating Motivation Survey (TEMS) using Confirmatory Factor Analysis (CFA) in a sample of 632 university students from the Western Brazilian Amazon. A cross-sectional study was conducted between December 2022 and April 2023 with participants of both sexes, aged 18 or older. In addition to CFA, psychometric analyses were performed, and a Structural Equation Model was developed to examine the relationships between individual characteristics (age, sex, and Body Mass Index (BMI)) and the TEMS constructs. The results showed that 58.3% of participants were female, with a mean age of 25.29 years. The CFA supported an eight-factor model (health, natural concerns, socialization, price, visual appeal, weight control, emotional control, and social image) with 24 items, presenting good validity and reliability indices. Older individuals and those with lower BMIs prioritized health, natural concerns, and weight control, while younger participants, women, and those with higher BMIs were more influenced by emotional control. The findings contribute to understanding eating motivations in culturally diverse contexts and may support strategies aimed at promoting healthier dietary behaviors and preventing diet-related chronic diseases. Full article