Search Results (217)

Background/Objectives: This study aimed to investigate the association between serum ferritin levels and functional impairment in children with Attention Deficit Hyperactivity Disorder (ADHD). In addition, we investigated whether this relationship remained significant after controlling for core symptom severity and examined the correlations between ferritin levels and ADHD symptom levels. Methods: The sample included 88 children aged 6–13 years: 44 diagnosed with ADHD and 44 healthy controls (HCs) matched for age and sex. ADHD symptom severity was assessed using Turgay’s DSM-IV-Based ADHD and Disruptive Behavior Disorders Screening Scale (T-DSM-IV-S; parent-report) and the Clinical Global Impression—Severity (CGI-S) scale (clinician-rated). Functional impairment was measured using the Weiss Functional Impairment Rating Scale—Parent Report (WFIRS-P). Serum ferritin levels were determined through venous blood samples. Statistical analyses included group comparisons, Spearman correlations, and partial correlations controlling for symptom severity. Results: Children with ADHD had significantly lower serum ferritin levels and higher levels of both symptom severity and functional impairment compared to HCs. Ferritin levels were negatively correlated with ADHD symptom severity and with functional impairment in the Life Skills domain. However, after controlling for ADHD symptom severity, the association with Life Skills was no longer statistically significant. Conclusions: Ferritin levels were found to be associated with both ADHD symptom severity and functional impairment in the Life Skills domain. However, this relationship was not independent of symptom severity, suggesting that core ADHD symptoms may mediate the impact of iron status on daily functioning. Due to the study’s limitations (e.g., cross-sectional design, small sample size, gender imbalance, and lack of inflammatory and dietary data), our findings should be interpreted with caution, as they do not establish causality or resolve the ongoing inconsistencies in the literature. These results underscore the relevance of iron metabolism in the clinical presentation of ADHD and highlight the need for future research to determine whether improving iron status could serve as an adjunctive strategy in the management of functional impairments in this population. Full article

Background/Objectives: Screen-related parenting practices (e.g., restriction, coviewing) influence the way children use screen devices. Although children start using screen devices (e.g., televisions [TV], tablets) in the first few years of life, rigorously developed measures of screen-related parenting practices for parents of toddlers do not exist. The objective of this study was to develop culturally and contextually relevant survey measures of screen-related parenting practices for use in Mexican American families with toddlers. Methods: Measures were developed using an exploratory sequential mixed methods (qualitative → quantitative) approach. Mexican American mothers of toddlers (15–26 months of age) participated in semi-structured interviews. Using the interview findings, domains of parenting practices across screen device types were identified, and survey items were developed. Items were administered by phone to 384 Mexican American mothers. Analyses included evaluation of the factor structure and psychometric properties of nine domains of parenting practices and evaluations of correlations between each scale and demographic characteristics. Results: Factor analyses supported a one-factor solution for each parenting practice as follows: Restrict TV Time (8 items), Coview TV (10 items), Behavioral Regulation with TV (12 items), Restrict Mobile Device Time (8 items); Coview Mobile Devices (10 items); Behavioral Regulation with Mobile Devices (16 items), Restrict Screen Content (8 items), Allow Screen Use Around Sleep (6 items), and Allow Screen Use While Eating (6 items). The reliabilities were acceptable (Cronbach’s alphas > 0.80). Hispanic acculturation, maternal age, and child age were correlated with many of the scales of parenting practices. Conclusions: The measures developed in this study offer a way to evaluate the use and impact of screen-related parenting practices in Mexican American families with toddlers. The use of these measures will enable investigators to identify relationships among parenting practices, screen use, and child well-being, which could inform the design of early childhood interventions promoting healthy screen use in this population. Full article

Family structure has long been regarded as an important determinant of household saving, yet the empirical evidence for developing economies remains limited. Using the 2018–2022 panels of the China Family Panel Studies (CFPS), a nationwide survey that follows 16,519 households across three waves, the present study investigates how family size, the elderly share, and the child share jointly shape saving behavior. A household fixed effects framework is employed to control for time-invariant heterogeneity, followed by a sequential endogeneity strategy: external-shock instruments are tested and rejected, lagged two-stage least squares implement internal instruments, and a dynamic System-GMM model is estimated to capture saving persistence. Robustness checks include province-by-year fixed effects, inverse probability weighting for attrition, balanced-panel replication, alternative variable definitions, lag structures, and sample filters. Family size raises the saving rate by 4.6 percentage points in the preferred dynamic specification (p < 0.01). The elderly ratio remains insignificant throughout, whereas the child ratio exerts a negative but model-sensitive association. A three-path mediation analysis indicates that approximately 26 percent of the total family size effect operates through scale economy savings on quasi-fixed expenses, 19 percent is offset by resource dilution pressure, and less than 1 percent flows through a precautionary saving channel linked to income volatility. These findings extend the resource dilution literature by quantifying the relative strength of competing mechanisms in a middle-income context and showing that cost-sharing economies dominate child-related dilution for most households. Policy discussion highlights the importance of public childcare subsidies and targeted credit access for rural parents, whose saving capacity is the most constrained by additional children. The study also demonstrates that fixed effects estimates of family structure can be upward-biased unless dynamic saving behavior and internal instruments are considered. Full article

The rising prevalence of cyberbullying in online environments has raised concerns about the well-being and safety of individuals. The objective of this research is to explore if the dark triad traits (Machiavellianism, psychopathy, and narcissism) function as mediators in the connections between maternal psychological control, paternal psychological control, cyberbullying, and cybervictimization. A sample of 1016 young adults participated in an online survey, providing self-reported data. The results revealed complex relationships among the variables examined. While most direct and indirect links were statistically significant, the direct connection between maternal psychological control and cyberbullying was significant only when paternal psychological control was not simultaneously included as a predictor. Furthermore, narcissism’s mediating effects were beneficial when Machiavellianism and psychopathy were excluded and negative otherwise. The results highlight that individuals with high degrees of parental psychological control are more prone to engage in manipulative actions and lack empathy, leading to cyberbullying and cybervictimization. Future research should disentangle the distinct roles of maternal and paternal control, investigate the interplay among dark triad traits in different social contexts, and consider how peer dynamics and digital environments may amplify or mitigate these effects. Full article

Background: Eosinophilic esophagitis is a chronic immune-mediated disease with increasing prevalence. In pediatric populations, it often coexists with IgE-mediated food sensitization. This dual diagnosis presents unique therapeutic challenges, including on the one hand both temporary and lifelong dietary restrictions, and on the other hand, therapeutic interventions with a potential impact on quality of life (QoL). Objectives: This study prospectively evaluated the prevalence of IgE-mediated food sensitization and allergy in children with EoE attending a tertiary center in Flanders, Belgium. Additionally, it prospectively documented dietary habits and restrictions in these children, with or without concomitant IgE-mediated food allergies, and assessed the impact of dietary management on quality of life compared to pharmacological treatment. Methods: We consecutively followed 30 children with biopsy-confirmed pediatric EoE (PedEoE) attending a tertiary referral center for at least 12 months. Patient demographics, allergy testing, dietary history, and treatment modalities were recorded. Symptom score and PedEoE QoL were assessed using validated Pediatric Eosinophilic Esophagitis Symptom Score (PEESS 2.0) and Pediatric Quality of Life Inventory (PedsQL 3.0) questionnaires. Statistical analysis was performed using the Mann–Whitney U test and Kruskal–Wallis test with Dunn’s test as a post hoc test. Results: Among 30 children with EoE (60% male, median age 8 years), 60 PedEoE QoL (PedsQL) and 39 symptom (PEESS) questionnaires were collected at one or more time points over a median follow-up of 14.5 months. IgE sensitization to common dietary triggers was observed in multiple patients, with varying clinical reactivity. Symptom scores tended to be higher in children without histological remission, though differences were not statistically significant (median PEESS 23.75 vs. 17.50, p = 0.1934). Grouped by degree of dietary restriction, QoL scores showed significant differences (child p = 0.0102; parent p = 0.0203), with children in the 1–2 food elimination group reporting better QoL compared to the 0 food elimination and >6 food elimination groups. No clear statistically significant differences were observed between the 1–2 food elimination group and the 3–4 or 5–6 food elimination groups. Conclusions: IgE sensitization is prevalent among pediatric EoE patients and has significant clinical implications for disease management. Treatment choice can influence not only disease control but also the QoL of both patients and their families. Full article

In the current information era, even preschool children are unable to withstand the “digital flood”. However, excessive exposure to electronic screens not only negatively impacts various aspects of children’s health and adaptation, but also harms family relationships. Based on family systems theory, social–cognitive learning theory, and attachment theory, this study examines the relationships between co-parenting and preschoolers’ problematic media use, as well as the underlying mechanism—the mediating role of parental phubbing and the moderating effect of secure attachment. A sample of 610 parents of preschoolers from three kindergartens in central China completed validated scales, including the Co-Parenting Scale, Parental Phubbing Scale, Children’s Electronic Media Use Questionnaire, and Secure Attachment Dimension of the Waters Attachment Q-sort. A moderated mediation model was tested using the PROCESS macro with bootstrap procedures. The results showed that, after controlling for the subjective family socioeconomic status and parental education level, (1) co-parenting was negatively associated with preschoolers’ problematic media use; (2) parental phubbing significantly mediated the relationship between co-parenting and preschoolers’ problematic media use; (3) secure attachment significantly moderated both the direct relation between co-parenting and the preschoolers’ problematic media use and the mediating effect of parental phubbing (the relation between parental phubbing and children’s problematic media use); furthermore, both of these effects were more pronounced in children with lower levels of secure attachment. These findings extend family systems and attachment theories by elucidating mechanisms underlying early media behaviors. Practically, interventions should promote collaborative co-parenting and reduce parental phubbing to mitigate children’s problematic media use, while fostering secure attachment to buffer digital risks. Full article

Meeting the rising demand for staple grains now requires cultivars that combine high yield, enhanced nutritional value, and strong chemical resilience. Blue-kernel landraces from central Mexico are rich in anthocyanins yet remain highly susceptible to post-emergence herbicides, whereas modern hybrids detoxify these compounds through cytochrome P450 (CYP450) enzymes. We crossed the anthocyanin-rich variety Polimaize with a CYP450-tolerant hybrid and evaluated the two parents and their F₁ segregants (designated “White” and “Yellow”) under greenhouse applications of mesotrione (75 g a.i. ha⁻¹), nicosulfuron (30 g a.i. ha⁻¹), and their mixture. Across 160 plants, the hybrid retained 95% of control dry matter and showed ≤7% foliar injury under all treatments, whereas Polimaize lost 28% biomass and exhibited 36% injury after nicosulfuron. The Yellow class matched hybrid performance while maintaining a blue pericarp and a β-carotene-rich endosperm, demonstrating that nutritional and agronomic traits can be stacked. The White class displayed heterosis-driven compensatory growth, exceeding its untreated biomass by 60% with nicosulfuron and by 82% with the mixture despite transient bleaching. Chlorophyll and carotenoid fluorescence revealed rapid, zeaxanthin-linked photoprotection in all tolerant genotypes, consistent with accelerated CYP450-mediated detoxification. These findings show that broad-spectrum herbicide tolerance can be introgressed into pigment-rich germplasm through conventional breeding, providing a non-transgenic path to herbicide-ready, anthocyanin-rich maize. The strategy preserves local biodiversity while delivering cultivars suited to intensive, weed-competitive agriculture and offers a template for integrating metabolic resilience into other native crops. Full article

Previous research has demonstrated that parental psychological control increases the likelihood of non-suicidal self-injury (NSSI) among college students. However, the underlying mechanisms of this association remain unclear. This study aims to investigate whether relative deprivation and depression serve as chain mediators in the relationship between paternal/maternal psychological control and NSSI, while also examining the moderating role of peer relationships. A total of 1158 college students (48.3% female; Mage = 19.26 years) completed assessments measuring parental psychological control, relative deprivation, depression, peer relationships, and NSSI. The results revealed that both paternal and maternal psychological control influence college students’ NSSI through two distinct pathways: the mediating role of depression, and a chain-mediating pathway involving relative deprivation followed by depression. Peer relationships moderated multiple associations, including those between paternal psychological control and NSSI, paternal psychological control and depression, relative deprivation and NSSI, and depression and NSSI. Notably, positive peer relationships helped mitigate the adverse effects stemming from paternal psychological control. However, peer relationships failed to buffer the negative impacts induced by maternal psychological control. These findings provide nuanced insights into the differential mechanisms through which paternal versus maternal psychological control influences college students’ NSSI. The results emphasize the necessity for distinct prevention and intervention strategies tailored to address the unique effects of paternal and maternal psychological control, thereby assisting practitioners in developing targeted approaches to reduce NSSI among college students. Full article

Soil erosion has caused the loss of black soil and exposed the soil parent material in the cultivated layer of sloping farmland in Northeast China. Straw return (STR) and manure fertilization (MF) are critical measures to improve soil quality and crop yield. However, the effect of STR and MF on the soil properties of the parent material remains unclear. We conducted a 1-year pot experiment in the field using the soil parent material of degraded black soil to evaluate the effects of STR and MF on soil nutrients, microbial community, and soybean yield. We analyzed these effects using two treatments (STR and MF) in three soybean growth stages (seedling, flowering, and maturity) and a control group (CK). The MF treatment had higher α and β diversity of soil microbial than the CK during all soybean growth stages. Similarly, STR had higher soil microbial α diversity at the maturity stage and lower diversity at the seedling stage. Co-occurrence network analysis suggested that STR and MF increased the proportion of positively correlated edges in soil bacterial and fungal networks compared to the CK. Notably, the treatments enriched beneficial taxa, such as Schizothecium (fungi) and Massilia (bacteria), which are associated with organic matter decomposition and nitrogen cycling. STR and MF significantly improved soil organic matter, total nitrogen, and carbon-nitrogen ratio (p < 0.05). Structural equation modeling (SEM) revealed that STR and MF directly increased soybean yield. This effect was primarily mediated by the significantly higher soil organic matter, total carbon, total nitrogen, and carbon-to-nitrogen ratio in the treatments than in the CK (p < 0.05). In summary, STR and MF improved soil fertility and soil microbial community diversity of degraded black soil. This study provides scientific methods to improve the fertility of degraded black soil and increase soybean production in the short term. Full article

Objectives: This review assesses how daily exposure to Information and Communication Technologies (ICTs) affects executive functions in children and adolescents and explores the roles of parents in mitigating potential negative impacts on cognitive development and emotional regulation. Methods: Following PRISMA guidelines, a systematic search was conducted from 2022 to 2024 using PubMed, Scopus, and Cochrane Library. The study criteria included cohort studies, randomized controlled trials (RCTs), quasi-RCTs, and systematic reviews. Data extraction and risk-of-bias assessments were performed using ROBIS and ROBINS-E tools. Due to the heterogeneity of the results, a narrative synthesis was carried out. Results: Ten studies were included for analysis, comprising a total of 231,117 children from nine countries on three continents. Most studies indicated that excessive ICT exposure negatively affects executive functions, particularly working memory, inhibitory control, cognitive flexibility, and attention. Adverse effects were linked to increased screen time, poor sleep quality, and multitasking. However, two studies found no significant association, highlighting the influence of contextual factors like socioeconomic status, parental mediation, and screen content type. Shared ICT use with parents or siblings appeared to reduce negative effects. Conclusions: Excessive ICT exposure is associated with impaired executive function development in children and adolescents. Parental supervision and structured ICT use may mitigate risks. Future research should investigate moderating factors, such as socioeconomic status and ICT content, to develop guidelines for healthy digital engagement in youth. Full article

Adolescence is a critical period for sociopolitical development, yet research has primarily focused on youth with explicit civic engagement, overlooking the role of community involvement in broader contexts. This mixed-methods study examines how adolescent community involvement—ranging from volunteering and advocacy to participation in sports, religious, and cultural activities—shapes sociopolitical control (SPC) in young adulthood. Using longitudinal quantitative survey data from 352 Canadian families, alongside qualitative interviews with 32 adult participants, we analyze how relationships with parents and peers mediate the link between community involvement and SPC. Regression analyses demonstrate that community involvement in high school predicts SPC at age 25, with parental support and positive peer relationships serving as significant mediators. Mediation analysis further reveals that relationships with mothers exert the strongest indirect effect on SPC, followed by relationships with fathers and peers. Qualitative findings highlight the mechanisms through which relational contexts foster or hinder SPC, illustrating that family values, peer norms, and early exposure to social issues shape long-term civic identity. These results underscore the importance of fostering relationally supportive environments that encourage diverse forms of adolescent community participation, contributing to both individual empowerment and broader democratic engagement. Full article

This study examined the sequential mediating roles of anxiety and depressive symptoms in the effect of school bullying victimization on suicidal ideation. This study utilized a convenience sample of college students across South Korea, and an online survey was conducted. This quantitative research analyzed data collected from 1037 participants. The sample consisted of an equal gender distribution, with a mean age of 23.65 years (range: 18–30). Additionally, 30% of participants reported a household income of four million won or less (approximately USD $3076). More than half of the participants’ parents had attained a college education or higher. Also, multiple mediation analyses were conducted to examine whether anxiety and depressive symptoms mediated the relationship between school bullying victimization and suicidal ideation. In the results, multiple mediation analyses showed that school bullying victimization does not have a direct effect on suicidal ideation. On the other hand, school bullying victimization has an indirect effect on suicidal ideation through anxiety and depressive symptoms, controlling for covariates. Based on these research results, implications for school bullying prevention and intervention were discussed. Full article

Dominant optic atrophy (DOA) is the most commonly inherited optic neuropathy. The majority of DOA is caused by mutations in the OPA1 gene, which encodes a dynamin-related GTPase located to the mitochondrion. OPA1 has been shown to regulate mitochondrial dynamics and promote fusion. Within the mitochondrion, proteolytically processed OPA1 proteins form complexes to maintain membrane integrity and the respiratory chain complexity. Although OPA1 is broadly expressed, human OPA1 mutations predominantly affect retinal ganglion cells (RGCs) that are responsible for transmitting visual information from the retina to the brain. Due to the scarcity of human RGCs, DOA has not been studied in depth using the disease affected neurons. To enable studies of DOA using stem-cell-derived human RGCs, we performed CRISPR-Cas9 gene editing to generate OPA1 mutant pluripotent stem cell (PSC) lines with corresponding isogenic controls. CRISPR-Cas9 gene editing yielded both OPA1 homozygous and heterozygous mutant ESC lines from a parental control ESC line. In addition, CRISPR-mediated homology-directed repair (HDR) successfully corrected the OPA1 mutation in a DOA patient’s iPSCs. In comparison to the isogenic controls, the heterozygous mutant PSCs expressed the same OPA1 protein isoforms but at reduced levels; whereas the homozygous mutant PSCs showed a loss of OPA1 protein and altered mitochondrial morphology. Furthermore, OPA1 mutant PSCs exhibited reduced rates of oxygen consumption and ATP production associated with mitochondria. These isogenic PSC lines will be valuable tools for establishing OPA1-DOA disease models in vitro and developing treatments for mitochondrial deficiency associated neurodegeneration. Full article

The fungus Puccinia triticina Eriks (Pt) is the cause of leaf rust, one of the most damaging diseases, which significantly reduces common wheat yields. In Pt-resistant adult plants, an APR-type resistance is observed, which protects the plant against multiple pathogen races and is distinguished by its persistence under production conditions. With a more complete understanding of the molecular mechanisms underlying the function of APR genes, it will be possible to develop new strategies for resistance breeding in wheat. Currently, mainly APR genes, such as Lr34, Lr46, and Lr67, are principally involved in resistance breeding as they confer durable resistance to multiple fungal races occurring under different climatic and environmental conditions. However, the mechanisms underlying the defence against pathogens mediated by APR genes remain largely unknown. Our research aimed to shed light on the molecular mechanisms related to resistance genes and miRNAs expression, underlying APR resistance to leaf rust caused by Pt. Furthermore, the present study aimed to identify and functionally characterize the investigated miRNAs and their target genes in wheat in response to leaf rust inoculation. The plant material included hybrid forms of wheat from the F₂ and BC₁F₁ generations, obtained by crossing the resistance cultivar Glenlea (CItr 17272) with agriculturally important Polish wheat cultivars. Biotic stress was induced in adult plants via inoculation with Pt fungal spores under controlled conditions. The RT-qPCR method was used to analyze the expression profiles of selected APR genes at five time points (0, 6, 12, 24, and 48 hpi). The results presented here demonstrate the differential expression of APR genes and miRNAs at stages of leaf rust development at selected timepoints after inoculation. We analyzed the expression of three leaf rust resistance genes, using different genetic backgrounds in F₂ and BC₁F₁ segregation materials, in leaf tissues after Pt infection. Our goal was to investigate potential differences resulting from the genetic background found in different generations of hybrid forms of the same parental forms. Gene ontology analysis predicted 190 target genes for tae-miR5384-3p and 167 target genes for tae-miR9653b. Our findings revealed distinct expression profiles for genes, with the highest expression levels observed mainly at 6, 24, and 48 hpi. The candidate gene Lr46-Glu2 displayed an upregulation, suggesting its potential involvement in the immune response against Pt infection. Full article

Intergenerational educational mobility means that adolescents graduate at a higher level (upward mobility) or lower level (downward mobility) than their parents did. Knowledge about early determinants supports upward and downward mobility at an early stage. Evidence about early determinants of educational mobility allows for the elaboration of educational strategies to minimize the correlation between family socio-economic status (SES) and student upper-secondary education level. In this longitudinal study (N = 2376), we examined the extent to which teacher and parent expectations in 7th grade (mean age: 13.2 years) predict the achievement and effort of adolescents with and without migration backgrounds and the probability of upward and downward mobility at the end of upper-secondary education. The results showed indirect effects of teacher and parent expectations on upward and downward mobility, mediated by student achievement, after controlling for gender and conscientiousness. The effects of parent expectations were stronger than the effects of teacher expectations. Effort predicted downward mobility more than achievement in mathematics and German. No differences were found between adolescents with and without migration backgrounds. In the case of the tracked Swiss education system, parents’ and teacher expectations predicted educational mobility over long periods. Full article