Search Results (508)

Background: Depression that is resistant to two or more adequate treatment trials—treatment-resistant depression (TRD)—is a prevalent clinical challenge. Although psychotherapies have been recommended by clinical guidelines as an alternative or adjunctive treatment strategy, the effectiveness of psychotherapy in individuals with TRD has not yet been evaluated through meta-analytic methods, primarily due to a limited number of trials. This highlights the necessity of personalized research targeting this specific population. This systematic review and meta-analysis aimed to summarize the evidence on psychotherapy in treating TRD. Methods: A systematic search was conducted following the Guidelines from Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Articles were included if they quantitatively examined the efficacy of psychotherapy on depression symptoms in individuals diagnosed with depression who had not responded to at least two prior treatments (i.e., pharmacotherapy and/or psychotherapy). Results: A total of 12 studies were included. The quality of evidence was evaluated as being globally moderate. When pooling all psychotherapies, a small-to-moderate, but significant, effect on depressive symptoms was observed compared to the control group (SMD = −0.49, CI = −0.63; −0.34). The observed effect remained unchanged after removing the outlier (SMD = −0.47, CI = −0.62; −0.32). When examining depressive symptoms by type of psychotherapy, Mindfulness-Based Cognitive Therapy (SMD = −0.51, CI = −0.76; −0.25), Cognitive Behavioral Therapy (SMD = −0.53, CI = −0.92; −0.14), and Cognitive Therapy (SMD = −0.51, CI = −1.01; −0.01) showed a moderately significant effect on depressive symptoms compared to the control group. Conclusions: Although this potentially represents the first meta-analysis in this area, the number of studies specifically addressing this complex population remains limited, and the existing literature is still in its early stages. Research focusing on TRD is notably sparse compared to the broader body of work on depression without treatment resistance. Consequently, it was not possible to conduct meta-analyses by type of psychotherapy across all treatment modalities and by type of control group. Due to several study limitations, there is currently limited evidence available about the effectiveness of psychotherapy for TRD, and further trials are needed. Beyond the treatments usually offered for depression, it is possible that TRD requires a personalized medicine approach. Full article

Pupillometry is commonly used to evaluate cognitive effort, attention, and facial expression response, offering valuable insights into human performance. The combination of eye tracking and facial expression data under the iMotions platform provides great opportunities for multimodal research. However, there is a lack of standardized pipelines for managing pupillometry data on a multimodal platform. Preprocessing pupil data in multimodal platforms poses challenges like timestamp misalignment, missing data, and inconsistencies across multiple data sources. To address these challenges, the authors introduced a systematic preprocessing pipeline for pupil diameter measurements collected using iMotions 10 (version 10.1.38911.4) during an endoscopy simulation task. The pipeline involves artifact removal, outlier detection using advanced methods such as the Median Absolute Deviation (MAD) and Moving Average (MA) algorithm filtering, interpolation of missing data using the Piecewise Cubic Hermite Interpolating Polynomial (PCHIP), and mean pupil diameter calculation through linear regression, as well as normalization of mean pupil diameter and integration of the pupil diameter dataset with facial expression data. By following these steps, the pipeline enhances data quality, reduces noise, and facilitates the seamless integration of pupillometry other multimodal datasets. In conclusion, this pipeline provides a detailed and organized preprocessing method that improves data reliability while preserving important information for further analysis. Full article

Data-driven approaches and calibration techniques for mathematical models, starting from observed data, are attracting more and more interest in the field of civil engineering. Among them, evolutionary polynomial regression (EPR) is an artificial intelligence (AI) technique that combines genetic algorithms (GAs) and regression strategies. However, the difficulties and uncertainties inherent in the method have pointed out how the implementation of proper computational methods together with the use of recent and qualified databases of experimental data are essential to carry out reliable formulations. In this framework, this paper explores a new robust EPR approach able to remove potential outliers and leverage points often occurring in biased dataset and simultaneously accounting for the effects of probabilistic uncertainties. Uncertainties are incorporated in the EPR methodology by adopting the direct perturbation method. In particular, it is shown the importance to set the parameters representative of experimental and analytical dispersions on the basis of the characteristics of the database in terms of homogeneity. With this purpose, two different case-studies are analyzed, dealing with the shear capacity of RC beams without stirrups and the compressive strength of cement-based mortar specimens, respectively. Finally, the best capacity equations are selected and discussed. Full article

Renewable fuels produced from animal- and plant-based edible oils have emerged as an alternative to oil and natural gas. Burgeoning interest in renewables can be attributed to the rapid depletion of fossil fuels caused by the global energy demand and the environmental advantages of renewables, specifically reduced emissions of greenhouse gases. An important property of the feedstock that is crucial for the conversion of edible oils to renewable fuels is the total acid number (TAN), as even a small increase in TAN for the feedstock can lead to corrosion of the catalyst in the refining process. Currently, the TAN is determined by potentiometric titration, which is time-consuming, expensive, and requires the preparation of reagents. As part of an effort to promote the use of renewable fuels, a partial least squares regression method with orthogonal signal correction to remove spectral information related to the sample background was developed to determine the TAN from the mid-infrared (IR) spectra of the feedstock. Digitally blended mid-IR spectral data were generated to fill in regions of the PLS calibration where there were very few samples. By combining experimental and digitally blended mid-IR spectral data to ensure adequate sample representation in all regions of the spectra–property calibration and better understand the spectra–property relationship through the identification of sample outliers in the original data that can be difficult to detect because of swamping, a PLS regression model for TAN (R² = 0.992, cross-validated root mean square error = 0.468, and bias = 0.0036) has been developed from 118 experimental and digitally blended mid-IR spectra of commercial feedstock. Thus, feedstock whose TAN value is too high for refining can be flagged using the proposed mid-IR method, which is faster and easier to use than the current titrimetric method. Full article

The implementation of an Indoor Positioning System (IPS) in a three-storey residential building employing WiFi signals that can also be used to track indoor movements is presented in this study. The movement of inhabitants is monitored through an Android smartphone by detecting the Received Signal Strength Indicator (RSSI) signals from WiFi Anchor Points (APs).Indoor movement is detected through a successive estimation of a target’s multiple positions. Using the K-Nearest Neighbors (KNN) and Particle Swarm Optimization (PSO) algorithms, these RSSI measurements are trained for estimating the position of an indoor target. Additionally, the Density-based Spatial Clustering of Applications with Noise (DBSCAN) has been integrated into the PSO method for removing RSSI-estimated position outliers of the mobile device to further improve indoor position detection and monitoring accuracy. We also employed Time Reversal Resonating Strength (TRRS) as a correlation technique as the third method of localization. Our extensive and rigorous experimentation covers the influence of various weather conditions in indoor detection. Our proposed localization methods have maximum accuracies of 92%, 80%, and 75% for TRRS, KNN, and PSO + DBSCAN, respectively. Each method also has an approximate one-meter deviation, which is a short distance from our targets. Full article

The acquisition of plant phenotypic traits is essential for selecting superior varieties, improving crop yield, and supporting precision agriculture and agricultural decision-making. Therefore, it plays a significant role in modern agriculture and plant science research. Traditional manual measurements of phenotypic traits are labor-intensive and inefficient. In contrast, combining 3D reconstruction technologies with autonomous vehicles enables more intuitive and efficient trait acquisition. This study proposes a 3D semantic reconstruction system based on an improved ORB-SLAM3 framework, which is mounted on an unmanned vehicle to acquire phenotypic traits in tomato cultivation scenarios. The vehicle is also equipped with the A * algorithm for autonomous navigation. To enhance the semantic representation of the point cloud map, we integrate the BiSeNetV2 network into the ORB-SLAM3 system as a semantic segmentation module. Furthermore, a two-stage filtering strategy is employed to remove outliers and improve the map accuracy, and OctoMap is adopted to store the point cloud data, significantly reducing the memory consumption. A spherical fitting method is applied to estimate the number of tomato fruits. The experimental results demonstrate that BiSeNetV2 achieves a mean intersection over union (mIoU) of 95.37% and a frame rate of 61.98 FPS on the tomato dataset, enabling real-time segmentation. The use of OctoMap reduces the memory consumption by an average of 96.70%. The relative errors when predicting the plant height, canopy width, and volume are 3.86%, 14.34%, and 27.14%, respectively, while the errors concerning the fruit count and fruit volume are 14.36% and 14.25%. Localization experiments on a field dataset show that the proposed system achieves a mean absolute trajectory error (mATE) of 0.16 m and a root mean square error (RMSE) of 0.21 m, indicating high localization accuracy. Therefore, the proposed system can accurately acquire the phenotypic traits of tomato plants, providing data support for precision agriculture and agricultural decision-making. Full article

The quality of wine largely depends on the quality of wine grapes, which is determined by their chemical composition. Therefore, measuring parameters related to grape ripeness, such as soluble solids content (SSC), is crucial for harvesting high-quality grapes. Visible–Near-Infrared (Vis/NIR) spectroscopy enables effective, non-destructive detection of SSC in grapes. However, commercial Vis/NIR spectrometers are often expensive, bulky, and power-consuming, making them unsuitable for on-site applications. This article integrated the AS7265X sensor to develop a low-cost handheld IoT multispectral detection device, which can collect 18 variables in the wavelength range of 410–940 nm. The data can be sent in real time to the cloud configuration, where it can be backed up and visualized. After simultaneously removing outliers detected by both Monte Carlo (MC) and principal component analysis (PCA) methods from the raw spectra, the SSC prediction model was established, resulting in an ${\mathrm{R}}_V^2$ of 0.697. Eight preprocessing methods were compared, among which moving average smoothing (MAS) and Savitzky–Golay smoothing (SGS) improved the ${\mathrm{R}}_V^2$ to 0.756 and 0.766, respectively. Subsequently, feature wavelengths were selected using UVE and SPA, reducing the number of variables from 18 to 5 and 6, respectively, further increasing the ${\mathrm{R}}_V^2$ to 0.809 and 0.795. The results indicate that spectral data optimization methods are effective and essential for improving the performance of SSC prediction models. The IoT Vis/NIR Spectroscopic System proposed in this study offers a miniaturized, low-cost, and practical solution for SSC detection in wine grapes. Full article

Calorific value and moisture content are the key indices to evaluate Caragana pellet fuel’s quality and combustion characteristics. Calorific value is the key index to measure the energy released by energy plants during combustion, which determines energy utilization efficiency. But at present, the determination of solid fuel is still carried out in the laboratory by oxygen bomb calorimetry. This has seriously hindered the ability of large-scale, rapid detection of fuel particles in industrial production lines. In response to this technical challenge, this study proposes using hyperspectral imaging technology combined with various chemometric methods to establish quantitative models for determining moisture content and calorific value in Caragana korshinskii fuel. A hyperspectral imaging system was used to capture the spectral data in the 935–1720 nm range of 152 samples from multiple regions in Inner Mongolia Autonomous Region. For water content and calorific value, three quantitative detection models, partial least squares regression (PLSR), random forest regression (RFR), and extreme learning machine (ELM), respectively, were established, and Monte Carlo cross-validation (MCCV) was chosen to remove outliers from the raw spectral data to improve the model accuracy. Four preprocessing methods were used to preprocess the spectral data, with standard normal variate (SNV) preprocessing performing best on the quantitative moisture content detection model and Savitzky–Golay (SG) preprocessing performing best on the calorific value detection method. Meanwhile, to improve the prediction accuracy of the model to reduce the redundant wavelength data, we chose four feature extraction methods, competitive adaptive reweighted sampling (CARS), successive pojections algorithm (SPA), genetic algorithm (GA), iteratively retains informative variables (IRIV), and combined the three models to build a quantitative detection model for the characteristic wavelengths of moisture content and calorific value of Caragana korshinskii fuel. Finally, a comprehensive comparison of the modeling effectiveness of all methods was carried out, and the SNV-IRIV-PLSR modeling combination was the best for water content prediction, with its prediction set determination coefficient $\left(R_P^2\right)$, root mean square error of prediction (RMSEP), and relative percentage deviation (RPD) of 0.9693, 0.2358, and 5.6792, respectively. At the same time, the moisture content distribution map of Caragana fuel particles is established by using this model. The SG-CARS-RFR modeling combination was the best for calorific value prediction, with its $R_P^2$, RMSEP, and RPD of 0.8037, 0.3219, and 2.2864, respectively. This study provides an innovative technical solution for Caragana fuel particles’ value and quality assessment. Full article

Accurate classification of jujube varieties is essential for ensuring their quality and medicinal value. Traditional methods, relying on manual detection, are inefficient and fail to meet the demands of modern production and quality control. This study integrates hyperspectral imaging with intelligent optimization algorithms—Zebra Optimization Algorithm (ZOA), Genetic Algorithm (GA), Particle Swarm Optimization (PSO), and Grey Wolf Optimization (GWO)—and a Support Vector Machine (SVM) model to classify jujube varieties. First, the Isolation Forest (IF) algorithm was employed to remove outliers from the spectral data. The data were then processed using Baseline correction, Multiplicative Scatter Correction (MSC), and Savitzky-Golay first derivative (SG1st) spectral preprocessing techniques, followed by feature enhancement with the Competitive Adaptive Reweighted Sampling (CARS) algorithm. A comparative analysis of the optimization algorithms in the SVM model revealed that SG1st preprocessing significantly boosted classification accuracy. Among the algorithms, GWO demonstrated the best global search ability and generalization performance, effectively enhancing classification accuracy. The GWO-SVM-SG1st model achieved the highest classification accuracy, with 94.641% on the prediction sets. This study showcases the potential of combining hyperspectral imaging with intelligent optimization algorithms, offering an effective solution for jujube variety classification. Full article

This paper presents a methodology for extracting and simulating arterial pulse waveform signals from Fabry–Perot interferometric measurements, emphasizing a practical approach for noninvasive cardiovascular assessment. A key novelty of this work is the presentation of a complete Python-based processing pipeline, which is made publicly available as open-source code on GitHub (git version 2.39.5). To the authors’ knowledge, no such repository for demodulating these specific interferometric signals to obtain a raw arterial pulse waveform previously existed. The proposed system utilizes accessible Python-based preprocessing steps, including outlier removal, Butterworth high-pass filtering, and min–max normalization, designed for robust signal quality even in settings with common physiological artifacts. Key features such as the rate of change, the Hilbert transform of the rate of change (envelope), and detected extrema guide the signal reconstruction, offering a computationally efficient pathway to reveal its periodic and phase-dependent dynamics. Visual analyses highlight amplitude variations and residual noise sources, primarily attributed to sensor bandwidth limitations and interpolation methods, considerations critical for real-world deployment. Despite these practical challenges, the reconstructed arterial pulse waveform signals provide valuable insights into arterial motion, with the methodology’s performance validated on measurements from three subjects against synchronized ECG recordings. This demonstrates the viability of Fabry–Perot sensors as a potentially cost-effective and readily implementable tool for noninvasive cardiovascular diagnostics. The results underscore the importance of precise yet practical signal processing techniques and pave the way for further improvements in interferometric sensing, bio-signal analysis, and their translation into clinical practice. Full article

This study focuses on enhancing crop yield prediction in plant factory environments through precise crop canopy image capture and background interference removal. This method achieves highly accurate recognition of the crop canopy projection area (CCPA), with a coefficient of determination (R²) of 0.98. A spatial resolution of 0.078 mm/pixel was derived by referencing a scale ruler and processing pixel counts, eliminating outliers in the data. Image post-processing focused on extracting the canopy boundary and calculating the crop canopy area. By incorporating crop yield data, a comparative analysis of 28 prediction models was performed, assessing performance metrics such as MSE, RMSE, MAE, MAPE, R², prediction speed, training time, and model size. Among them, the Wide Neural Network model emerged as the most optimal. It demonstrated remarkable predictive accuracy with an R² of 0.95, RMSE of 27.15 g, and MAPE of 11.74%. Furthermore, the model achieved a high prediction speed of 60,234.9 observations per second, and its compact size of 7039 bytes makes it suitable for efficient, real-time deployment in practical applications. This model offers substantial support for managing crop growth, providing a solid foundation for refining cultivation processes and enhancing crop yields. Full article

This study investigates whether eye movement abnormalities can differentiate between distinct clinical annotations of dyslexia, attention deficit, or school learning difficulties in children. Utilizing a selection of saccade and vergence eye movement data from a large clinical dataset recorded across 20 European centers using the REMOBI and AIDEAL technologies, this research study focuses on individuals annotated with only one of the three annotations. The selected dataset includes 355 individuals for saccade tests and 454 for vergence tasks. Eye movement analysis was performed with AIDEAL software. Key parameters, such as amplitude, latency, duration, and velocity, are extracted and processed to remove outliers and standardize values. Machine learning models, including logistic regression, random forest, support vector machines, and neural networks, are trained using a GroupKFold strategy to ensure patient data are present in either the training or test set. Results from the machine learning models revealed that children annotated solely with dyslexia could be successfully identified based on their saccade and vergence eye movements, while identification of the other two categories was less distinct. Statistical evaluation using the Kruskal–Wallis test highlighted significant group mean differences in several saccade parameters, such as a velocity and latency, particularly for dyslexics relative to the other two groups. These findings suggest that specific terminology, such as “dyslexia”, may capture unique eye movement patterns, underscoring the importance of eye movement analysis as a diagnostic tool for understanding the complexity of these conditions. This study emphasizes the potential of eye movement analysis in refining diagnostic precision and capturing the nuanced differences between dyslexia, attention deficits, and general learning difficulties. Full article

Cardiovascular diseases (CVDs) rank among the leading global causes of mortality, underscoring the necessity for early detection and effective management. This research presents a novel prediction model for CVDs utilizing a bagging algorithm that incorporates histogram gradient boosting as the estimator. This study leverages three preprocessed cardiovascular datasets, employing the Local Outlier Factor technique for outlier removal and the information gain method for feature selection. Through rigorous experimentation, the proposed model demonstrates superior performance compared to conventional machine learning approaches, such as Logistic Regression, Support Vector Classification, Gaussian Naïve Bayes, Multi-Layer Perceptron, k-nearest neighbors, Random Forest, AdaBoost, gradient boosting, and histogram gradient boosting. Evaluation metrics, including precision, recall, F1 score, accuracy, and AUC, yielded impressive results: 93.90%, 98.83%, 96.30%, 96.25%, and 0.9916 for dataset I; 94.17%, 99.05%, 96.54%, 96.48%, and 0.9931 for dataset II; and 89.81%, 82.40%, 85.91%, 86.66%, and 0.9274 for dataset III. The findings indicate that the proposed prediction model has the potential to facilitate early CVD detection, thereby enhancing preventive strategies and improving patient outcomes. Full article

Lunar orbiter image matching is a critical process for achieving high-precision lunar mapping, positioning, and navigation. However, with the Moon’s weak-texture surface and rugged terrain, lunar orbiter images generally suffer from inconsistent lighting conditions and exhibit varying degrees of non-linear intensity distortion, which pose significant challenges to image traditional matching. This paper presents a robust feature matching method based on crater neighborhood structure, which is particularly robust to changes in illumination. The method integrates deep-learning based crater detection, Crater Neighborhood Structure features (CNSFs) construction, CNSF similarity-based matching, and outlier removal. To evaluate the effectiveness of the proposed method, we created an evaluation dataset, comprising Multi-illumination Lunar Orbiter Images (MiLOIs) from different latitudes (a total of 321 image pairs). And comparative experiments have been conducted using the proposed method and state-of-the-art image matching methods. The experimental results indicate that the proposed approach exhibits greater robustness and accuracy against variations in illumination. Full article

This study presents a hybrid ensemble learning framework for the joint detection and motor severity prediction of Parkinson’s disease (PD) using biomedical voice features. The proposed architecture integrates a deep multimodal fusion model with dense expert pathways, multi-head self-attention, and multitask output branches to simultaneously perform binary classification and regression. To ensure data quality and improve model generalization, preprocessing steps included outlier removal via Isolation Forest, two-stage feature scaling (RobustScaler followed by MinMaxScaler), and augmentation through polynomial and interaction terms. Borderline-SMOTE was employed to address class imbalance in the classification task. To enhance prediction performance, ensemble learning strategies were applied by stacking outputs from the fusion model with tree-based regressors (Random Forest, Gradient Boosting, and XGBoost), using diverse meta-learners including XGBoost, Ridge Regression, and a deep neural network. Among these, the Stacking Ensemble with XGBoost (SE-XGB) achieved the best results, with an R² of 99.78% and RMSE of 0.3802 for UPDRS regression and 99.37% accuracy for PD classification. Comparative analysis with recent literature highlights the superior performance of our framework, particularly in regression settings. These findings demonstrate the effectiveness of combining advanced feature engineering, deep learning, and ensemble meta-modeling for building accurate and generalizable models in voice-based PD monitoring. This work provides a scalable foundation for future clinical decision support systems. Full article