Search Results (109)

Background: Gestational diabetes mellitus (GDM) affects 7–9% of pregnancies worldwide and is associated with adverse maternal and neonatal outcomes. Nutritional therapy is a key component of GDM management. However, inconsistencies exist across international and national guidelines regarding macronutrient distribution, glycemic targets, and micronutrient supplementation. This systematic review aims to compare updated nutritional recommendations for GDM across major health organizations and identify areas of consensus, divergence, and evidence gaps. Methods: This systematic review was conducted following PRISMA guidelines and registered in PROSPERO (CRD420251026194). A comprehensive literature search was performed in PubMed, Scopus, and Google Scholar (concluding March 2025), along with manual searches of official websites of professional health organizations (e.g., ADA, WHO, NICE, IDF). Guidelines published within the last 10 years (or the most relevant national guideline if slightly older), available in English or with access to translation, and including explicit nutritional recommendations for GDM were included. Data were extracted on macronutrient composition, glycemic targets, and micronutrient supplementation, with evaluation of the supporting evidence and regional context, incorporating findings from recent key guideline updates. Results: In total, 12 guidelines met the inclusion criteria. While all guidelines emphasized carbohydrate moderation and adequate fiber intake, significant discrepancies were found in carbohydrate quality recommendations (e.g., low-glycemic index focus vs. total carbohydrate restriction), postprandial glucose targets (e.g., 1-h vs. 2-h measurements and varying thresholds like <120 vs. <140 mg/dL), and the use of non-routine micronutrients such as chromium, selenium, and omega-3 fatty acids (generally lacking endorsement). Recent updates from key bodies like ADA, Diabetes Canada, and KDA largely maintain these core stances but show increasing emphasis on dietary patterns and acknowledgement of CGM technology, without resolving key discrepancies. Cultural adaptability and behavioral counselling strategies were minimally addressed across most guidelines. Conclusions: Despite general agreement on the principal recommendations of nutritional management in GDM, substantial variation persists in specific recommendations, even considering recent updates. Consistent, evidence-based, and culturally adaptable guidelines incorporating implementation strategies are needed to optimize care and reduce disparities in GDM management across regions. Full article

Purslane (Portulaca oleracea L.) is a plant recognized as a valuable source of nutrients and bioactive compounds such as omega-3 fatty acids, antioxidants, vitamins, and minerals. This study investigates the effects of grinding techniques (knife, ball, and planetary ball mill) on the properties of purslane powder (surface microstructure, particle size distribution, and color), their influence on the phenolic content in the extracts of purslane powder before and after in vitro simulated digestion process, and the antioxidant activity of the purslane extracts. The results showed that applied grinding techniques affected the particle size distribution and surface morphology of the powder, which in turn influenced the gastrointestinal stability of the dominant phenolic compounds in purslane powder extracts. The powder obtained via ball milling, characterized by the highest proportion of fine particles (x < 100 µm), showed the highest content of total phenolics (656 mg GAE/L). Ball milling resulted in high preservation of the dominant phenolic acids in the powder extract after simulated gastric and intestinal digestion (83.55% and 69.42%) and high free radical scavenging activity (DPPH and ABTS) and ferric reducing power (FRAP). The results obtained emphasize the nutritional and biological benefits of purslane in the form of a fine powder. Full article

Schizochytrium-derived omega-3 polyunsaturated fatty acids (e.g., docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)) are proven to be health-beneficial bioactive substances that have been widely applied in the pharmaceutical, nutraceutical, and food industries. In this work, the newly isolated Schizochytrium sp. FJ-1 strain was selected to investigate the effects of salinity on the growth performance, lipid production, DHA yield, and positional distribution of triacylglycerols (TAGs). In addition, Schizochytrium sp. 20888 was used as a control strain. The obtained results showed that Schizochytrium sp. FJ-1 could grow with a low biomass in the absence of sea salt; however, Schizochytrium sp. 20888 did not grow in the medium without sea salt. Moreover, Schizochytrium sp. FJ-1 achieved the highest biomass in 10‰ salinity, whilst Schizochytrium sp. 20888 attained the greatest biomass in 40‰ salinity. In terms of the total lipid content and TAG fraction percentage, Schizochytrium sp. FJ-1 grown in 5–20‰ salinity had high total lipid contents (57.04–60.02%), with TAGs accounting for over 90% of the lipid fraction. The highest DHA contents for total lipids (41.38%) and TAGs (40.18%) were obtained when Schizochytrium sp. FJ-1 was grown under 10‰ salinity conditions. Additionally, under the same culture condition, EPA contents of lipids and TAGs were significantly higher for Schizochytrium sp. FJ-1 compared with Schizochytrium sp. 20888. Furthermore, nuclear magnetic resonance analysis found that the salinity level had a distinct impact on the positional distribution of DHA in TAGs in these two Schizochytrium strains. Schizochytrium sp. FJ-1 grown under 40‰ salinity conditions produced TAGs with the greatest percentage of sn-2 DHA (81.24%). The percentages were higher than those found for the other groups of this microalga and Schizochytrium sp. 20888. Taken together, Schizochytrium sp. FJ-1 could be a potential candidate to produce highly valued DHA lipids or TAG bioproducts by regulating salinity. Full article

This paper introduces a novel framework for multi-period portfolio optimization that incorporates intertemporal spectral risk measures (ISRMs). The model dynamically manages risk by considering both tail risk, through spectral risk measures, and overall portfolio volatility, through variance, across multiple time periods. This approach allows investors to specify time-varying risk preferences via a spectral function, making it particularly suitable for investors with evolving risk management needs. We develop an efficient solution methodology based on the Progressive Hedging Algorithm (PHA), enhanced with specialized reformulations to handle linkage objectives and constraints inherent in the multi-period setting. We establish the theoretical convergence properties of our algorithm, demonstrating a q-linear convergence rate under mild conditions. Numerical experiments validate the effectiveness of our approach, showing that the intertemporal weighting scheme provides more consistent risk management across the investment horizon compared to terminal-focused strategies. Notably, our approach exhibits superior downside risk protection, as evidenced by improved Sortino and Omega ratios, and generates more balanced wealth distributions with moderate tails. These findings offer valuable insights and practical tools for investors seeking to implement dynamic risk-management strategies that account for both intermediate and terminal objectives. Full article

Background: The use of natural feed supplements in rabbit farming can enhance the nutritional value of meat and improve its properties as a functional food. Aim: This study aimed to analyze the effects of supplementing rabbit feed with linseed meal, fodder yeast, and a combination of linseed meal and selenium yeast on meat quality. The study included 45 rabbits kept in household farms, distributed into three groups, namely, the control group (CG—fed a basic diet consisting of alfalfa pellets); group 1 (G1—supplemented with linseed meal and fodder yeast), and group 2 (G2—supplemented with linseed meal and selenium yeast). Following the three-month study period, rabbit meat samples were analyzed for nutritional composition. Results: The results revealed reduced rabbit meat caloricity in G1 and G2 (ME = 111.74 and 112.58 kcal/100 g, respectively), when compared to CG datasets. Peak polyunsaturated fatty acid content was observed in G2, with omega-3 and omega-6 fatty acids content at 12.326% and 18.382%, respectively. Total mineral content of rabbit meat peaked in G2 (720.99 mg/g), whereas CG (603.71 mg/g) had the lowest content. Conclusions: These results demonstrate that feed supplements such as linseed meal, fodder yeast, and selenium yeast can significantly enhance the nutritional and functional properties of rabbit meat, offering a sustainable approach to producing nutrient-rich animal-derived foods. Full article

This study utilizes Computational Fluid Dynamics (CFD) to optimize the aerodynamic performance of a Formula 1 (F1) car diffuser, investigating the effects of vane placements, end-flap positions, and other structural modifications. Diffusers are critical in managing airflow, enhancing downforce, and reducing drag, directly influencing vehicle stability and speed. Despite ongoing advancements, the interaction between diffuser designs and turbulent flow dynamics requires further exploration. A Three-Dimensional k-Omega-SST RANS-based CFD methodology was developed to evaluate the aerodynamic performance of various diffuser configurations using Star CCM+. The findings reveal that adding lateral vane parallel to the divergence section improved high-intensity fluid flow distribution within the main channel, achieving 13.49% increment in downforce and 5.58% reduction in drag compared to the baseline simulation. However, incorporating an airfoil cross-section flap parallel to the divergence end significantly enhances the car’s performance, leading to a substantial improvement in downforce while relatively small increase in drag force. This underscores the critical importance of precise flap positioning for optimizing aerodynamic efficiency. Additionally, the influence of adding flaps underneath the divergence section was also analyzed to manipulate boundary layer separation to achieve improved performance by producing additional downforce. This research emphasizes the critical role of vortex management in preventing flow detachment and improving diffuser efficiency. The findings offer valuable insights for potential FIA F1 2023 undertray regulation changes, with implications for faster lap times and heightened competitiveness in motorsports. Full article

Obesity is a significant global health issue, profoundly affecting metabolic and cardiovascular health and other related chronic conditions. In Chile, the prevalence of obesity is among the highest within the Organisation for Economic Cooperation and Development (OECD) countries, highlighting a critical public health challenge. This narrative review examines current evidence on the independent and potential synergistic roles of omega-3 fatty acids and exercise in managing obesity-related metabolic dysfunction. Omega-3 fatty acids, particularly eicosapentaenoic acid (EPA), have been shown to lower triglyceride levels, enhance lipid metabolism, and modulate inflammation via pathways involving peroxisome proliferator-activated receptors (PPARs) and sterol regulatory element-binding protein-1c (SREBP-1c). Exercise interventions, such as moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT), provide distinct yet complementary metabolic benefits. Specifically, MICT improves body fat distribution and mitochondrial efficiency, whereas HIIT has notable effects on metabolic adaptability and insulin signaling. Additionally, emerging evidence points toward a potential role of the kinin-kallikrein system, particularly kallikrein 7 (KLK7), in obesity-associated insulin resistance. Despite these promising findings, several knowledge gaps persist regarding optimal dosing, intervention timing, population-specific effects, and the exact mechanisms behind the potential synergistic interactions between omega-3 supplementation and structured exercise. This review emphasizes the importance of conducting further research, particularly controlled clinical trials, to clarify these combined interventions’ effectiveness and establish targeted therapeutic strategies tailored to individual metabolic profiles. Full article

Fish oil, a rich source of omega-3 polyunsaturated fatty acids (PUFA), is a vital nutritional component, but considering its susceptibility to oxidation, it could benefit from an effective encapsulation system. This study aims to optimize high-pressure homogenization (HPH) parameters (pressure, number of passes) and wall material composition to maximize the encapsulation efficiency (EE) of fish oil, using different concentrations of maltodextrin with Arabic gum or sodium alginate. Key metrics such as emulsion droplet size, encapsulation efficiency, color, and oxidation in the final freeze-dried product were evaluated. Optimal values were achieved at 60 MPa, resulting in the lowest mean droplet diameter (369.4 ± 3.8 nm) and narrow distribution (0.197 ± 0.011) of the fish oil micelles prepared with a mixture of Tween80 and sodium caseinate as an emulsifier, without significant oxidation after four cycles of homogenization, while 80 MPa led to the highest EE (up to 95.6%), but increased oxidation. The combination of 10% w/w Arabic gum or 1% w/w sodium alginate with 20% w/w maltodextrin achieved the highest EE (79.1–82.9%) and whiteness index (82.5–83.0), indicating neutral-colored well-encapsulated fish oil without oxidation, which is desirable for product stability. Selecting optimal HPH conditions and wall material is crucial for the encapsulation efficiency and oxidation stability of omega-3 PUFA delivered in dehydrated forms. Full article

To investigate the size effect on the energy characteristics of axial flow pumps, this study scaled the original model size based on the head similarity principle, resulting in four size schemes (Schemes 2–4 correspond to 3, 5, and 10 times the size of Scheme 1, respectively). By solving the unsteady Reynolds-averaged Navier–Stokes (URANS) equations with the Shear Stress Transport (SST) k-omega turbulence model, the external characteristic parameters and internal flow field structures were predicted. Additionally, the spatial distribution of internal hydraulic losses was analyzed using entropy generation theory. The results revealed three key findings: (1) the efficiency of axial flow pumps significantly improves with increasing size ratio, with Scheme 4 exhibiting a 6.1% efficiency increase compared to Scheme 1; (2) as the size ratio increases, the entropy production coefficients of all hydraulic components decrease, with the impeller and guide vanes in Scheme 4 showing reductions of 55.1% and 56.5%, respectively, compared to Scheme 1; (3) the high entropy generation coefficient regions in the impeller and guide vanes are primarily concentrated near the rim, with their area decreasing as the size ratio increases. Specifically, the entropy production coefficients at the rim of impeller and guide vanes in Scheme 4 decreased by 84.85% and 58.2%, respectively, compared to Scheme 1. These findings provide valuable insights for the selection and optimization of axial flow pumps in applications such as cross-regional water transfer, agricultural irrigation, and urban drainage systems. Full article

Background: The NAC transcription factor family of genes is one of the largest families of transcription factors in plants, playing important functions in plant growth and development, response to adversity stress, disease resistance, and hormone signaling. In this study, we identified the number of members of the Panax notoginseng NAC (PnNAC) gene family and conducted a comprehensive analysis of their physicochemical characteristics, chromosomal location, evolutionary features, and expression patterns both in different parts of the plant at different growth stages and in response to infection by Alternaria panax. Methods: The NAC gene family in P. notoginseng was identified using Hidden Markov Model (HMMER) and National Center of Biotechnology Information Conserved Domain Database (NCBI CDD), and their physicochemical properties were analyzed with Perl scripts. Phylogenetic relationships were determined using Clustal Omega and FastTree, and gene structures were visualized with an R script. Promoter regions were analyzed with PlantCARE, motifs with MEME and ggmotif, and transcriptome data were processed using Hical Indexing for Spliced Alignment of Transcripts (HISAT2) and HTseq. Results: This study identified 98 PnNAC genes in P. notoginseng, analyzed their characteristics (protein lengths 104–882 aa, molecular weights 11.78–100.20 kDa, isoelectric points 4.12–9.75), location (unevenly distributed on 12 chromosomes, no tandem repeats), evolution, and expression patterns (distinct in different parts, growth stages, and after A. panax infection). Conclusions: PnNAC plays an important role in the growth and development of P. notoginseng and in its response to A. panax. PnNAC could be a candidate gene for further research on and functional analysis of P. notoginseng disease resistance. Full article

Numerical investigations were conducted to analyze the coupling effects of pulsed H₂ jets and nanosecond-pulsed actuation (NS-SDBD) in a supersonic crossflow. The FVM was employed to solve the multi-component 2D URANS equations with the SST k-omega turbulence model, while H₂-air combustion was described using a seven species–seven reactions chain reaction model, and the plasma thermal effect was represented by a phenomenological model. The backward-facing step flows with an inlet Mach number of 2.5 and a pulsed jet frequency of 10 kHz under different actuation conditions were simulated. The combustion enhancement mechanism under an actuation frequency of 20 kHz was analyzed. Research indicates that compression waves induced by NS-SDBD enhance H₂-air mixing and facilitate temperature transport as the flow progresses. This progress is significantly associated with the flow structures generated by pulsed jets. Under this condition, the fuel utilization rate in the flow field increased by 61.2%, the total pressure recovery coefficient increased by 5.34%, and the outlet total temperature slightly increased even with a 50% reduction in fuel flow rate. Comparative analysis of different actuation cases demonstrates that evenly distributed actuation within the jet cycle yields better effects. The innovation of this study lies in proposing and exploring a potential method to address inadequate combustion under high-speed inflow conditions, which couples NS-SDBD with pulsed hydrogen jets. Full article

Squid viscera, a byproduct of squid processing, contains oil rich in omega-3 fatty acids (up to 10% by mass) and the antioxidant astaxanthin. However, its high free fatty acid (FFA) content compromises stability. To address this, pilot-scale (200 L) enzymatic re-esterification of squid oil using immobilized lipase (Lipozyme RMIM) was demonstrated, resulting in high acylglyceride yields. The processed oil was analyzed for oxidation kinetics and thermodynamics using Rancimat, fatty acid composition using GC, omega-3 fatty acid positional distribution in the acylglyceride product using ¹³C NMR, and astaxanthin content. Lipase treatment reduced FFA levels from 44% to 4% and increased acylglycerides to 93% in squid oil. This reduction in FFA was accompanied by significantly increased stability (0.06 to 18.9 h by Rancimat). The treated oil showed no loss in astaxanthin (194.1 µg/g) or omega-3 fatty acids, including docosahexaenoic acid (DHA). DHA remaining predominantly at sn-2 indicated that the naturally occurring positional distribution of this omega-3 FFA was retained in the product. Lipase treatment significantly enhanced oxidative stability, evidenced by improved thermodynamic parameters (E_a 94.15 kJ/mol, ΔH 91.09 kJ/mol, ΔS −12.6 J/mol K) and extended shelf life (IP₂₅ 74.42 days) compared to starting squid oil and commercial fish/squid oils lacking astaxanthin. Thus, lipase treatment offers an effective strategy for reducing FFA levels and producing oxidatively stable, astaxanthin-rich acylglyceride squid oil with DHA retained at the nutritionally favored sn-2 position. Full article

The mortality rate of ovarian cancer (OC) remains the highest among female gynecological malignancies. Advanced age is the highest risk factor for OC development and progression, yet little is known about the role of the aged tumor microenvironment (TME). We conducted RNA sequencing and lipidomic analysis of young and aged gonadal adipose tissue from rat xenografts before and after OC formation. The rates of tumor formation (p = 0.047) and tumor volume (p = 0.002) were significantly higher in the aged rats than in their young counterparts. RNA sequencing data showed significant differences in gene expression profiles between the groups of young and aged rat adipose tissues (p < 0.05), including S100a8, S100a9, Il1rl1, Lcn2, C3, Hba-a1, Fcna, and Pnpla3. At the time of tumor generation, there were also changes in the lipid components within the gonadal adipose tissues of young and aged rats, with higher levels of free fatty acids (FFAs) and triglycerides (TGs) in aged rats. Furthermore, the aged TME showed changes in immune cell composition, especially inflammation-related cells, including neutrophils, myeloid dendritic cells, CD4+ T cells (non-regulatory), and mast cell activation (p < 0.05). The correlation between S100a8, S100a9, neutrophil, and omega-5, FFA 18:3 levels was also determined. Additionally, omega-5, which is downregulated in aged rats, inhibited OC cell proliferation in vitro (p < 0.001). Our study suggests that the aged TME promotes OC proliferation resulting from age-related changes in gene/pathway expression, lipid metabolism, and immune cell distribution. Targeting the aging adipose microenvironment, particularly lipid metabolism, is a promising therapeutic strategy for OC and warrants further investigation. Significance: The aging microenvironment contributes to OC development and progression because of changes in the immune response regulatory genes S100a8 and S100a9, secreted by adipocytes, preadipocytes, or neutrophils, and by altering omega-5 metabolism. Full article

Objectives: This study evaluated the psychometric properties of the ceroid lipofuscinosis type 2 Quality of Life (CLN2 QoL) questionnaire. Methods: Data from children with CLN2 disease aged 3–16 years receiving cerliponase alfa in the BMN 190-201 and BMN 190-202 clinical studies, collected via purposive sampling, were used to assess convergent and divergent validity, internal consistency and reliability. The clinically important difference (CID) was estimated with distribution- and anchor-based methods. Descriptive and inferential statistical analyses were conducted using IBM SPSS. Results: CLN2 QoL data of 22 participants were analysed. Ceiling effects were observed in 22 items (35% threshold); no floor effects were observed. Internal consistency analysis showed good reliability (Cronbach’s alpha and Omega reliability >0.7) for four domains at study completion; only one domain had good reliability at baseline. All domains had good test–retest reliability (correlation >0.5) except Feeding With G-Tube and Seizures. Convergent and divergent correlation analysis showed moderate-strong correlations (>0.4) between PedsQL and CLN2 QoL total scores, between the Pediatric Quality of Life Inventory (PedsQL) total score and most CLN2 QoL domains at baseline, and between CLN2 QoL total score and most PedsQL domains at week 97. Known groups validity showed a significant difference in means for the Behaviour domain (p = 0.05) for reasons that could not be clarified. CID was 6.79–12.94 for domains; total score CID was 6.91 using distribution-based and 6.13–13.05 using anchor-based methods. Conclusions: This study is the first to validate the CLN2 QoL and to estimate the CID of this instrument in CLN2 patients. Our results show good validity and reliability of this tool. Full article

Understanding the aerodynamic performance of scaled-down models is vital for providing crucial insights into wind energy optimization. In this study, the aerodynamic performance of a scaled-down model (12%) was investigated. This validates the findings of the unsteady aerodynamic experiment (UAE) test sequence H. UAE tests provide information on the configuration and conditions of wind tunnel testing to measure the pressure coefficient distribution on the blade surface and the aerodynamic performance of the wind turbine. The computational simulations used shear stress transport and kinetic energy (SST K-Omega) and transitional shear stress transport (SST) turbulence models, with wind speeds ranging from 5 m/s to 25 m/s for the National Renewable Energy Laboratory (NREL) Phase VI and 4 m/s to 14 m/s for the 12% scaled-down model. The aerodynamic performance of both cases was assessed at representative wind speeds of 7 m/s for low, 10 m/s for medium, and 20 m/s for high flow speeds for NREL Phase VI and 7 m/s for low, 9 m/s medium, and 12 m/s for the scaled-down model. The results of the SST K-Omega and transitional SST models were aligned with experimental test measurement data at low wind speeds. However, the SST K-Omega torque values exhibited a slight deviation. The transitional SST and SST K-Omega models yielded aerodynamic properties that were comparable to those of the 12% scaled-down model. The torque values obtained from the simulation for the full-scale NREL Phase VI and the scaled-down model were 1686.5 Nm and 0.8349 Nm, respectively. Both turbulence models reliably predicted torque and pressure coefficient values that were consistent with the experimental data, considering specific flow regimes. The pressure coefficient was maximum at the leading edge of the wind turbine blade on the windward side and minimum on the leeward side. For the 12% scaled-down model, the flow simulation results bordering the low-pressure region of the blade varied slightly. Full article