Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Article Types

Countries / Regions

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Search Results (13,447)

Search Parameters:
Keywords = older adult

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
14 pages, 5462 KB  
Review
Development and Validation of Digital Decision Aids to Support Medication Adherence in Older Adults: A Scoping Review
by Ghada Elba, Shaheena Fakir, Rishabh Sharma, Halak Patel, Caitlin Carter and Tejal Patel
Pharmacy 2026, 14(6), 129; https://doi.org/10.3390/pharmacy14060129 (registering DOI) - 2 Sep 2026
Abstract
Introduction: The development of technology to support medication management and adherence among older adults is rising. Many of these technologies offer diverse features, which add complexity when making a choice. Evidence-based decision aids can inform decision-making in such situations. To inform the development [...] Read more.
Introduction: The development of technology to support medication management and adherence among older adults is rising. Many of these technologies offer diverse features, which add complexity when making a choice. Evidence-based decision aids can inform decision-making in such situations. To inform the development of such a decision aid, it is necessary to review the literature on the development and validation of decision aids that impact medication adherence. Therefore, this study aims to review the available literature on digital decision aids that examine the impact on medication adherence and investigate their features, development, and validation processes. Methods: Adopting the Arksey and O’Malley scoping review framework, a comprehensive search was conducted using PubMed, Embase, CINAHL, IPA and Scopus, using four key concepts: medication adherence, decision aids/tools, older adults, and software/technology. Eligibility criteria included studies that enrolled older adults with a mean/median age of 65 years, published protocols for studies that supported decision-making, published in the English language, and examined and reported the development and/or validation and/or evaluation of digital decision aids. Results: Our search identified 3526 records. After removing 947 duplicates, 2579 records underwent title and abstract screening, of which 726 proceeded to full-text screening. Following full-text screening, one research protocol met all eligibility criteria and was included in the review. An additional 16 systematic reviews were examined to identify potentially relevant studies from their reference lists; however, none of the studies identified through this supplementary screening met the eligibility criteria. Conclusion: The limited number of eligible studies shows a substantial gap in the literature on the development and validation of digital decision aids that support medication adherence among older adults. Further research in this field is needed to develop and validate evidence-based and user-centered digital decision aids for this population. Full article
Show Figures

Figure 1

39 pages, 11395 KB  
Review
Long-Term Cognitive and Functional Outcomes of Anesthesia and Surgery in Patients with Dementia
by Antea Krsek, Lana Sabati, Ivana Krajina, Zofia Nikola Lewandowska, Vlatka Sotosek and Lara Baticic
Healthcare 2026, 14(17), 2821; https://doi.org/10.3390/healthcare14172821 - 2 Sep 2026
Abstract
Dementia is one of the leading causes of disability and dependence among older adults and is increasingly encountered in patients undergoing surgery. As populations age and surgical interventions become more common, understanding the perioperative care of patients with pre-existing dementia has become an [...] Read more.
Dementia is one of the leading causes of disability and dependence among older adults and is increasingly encountered in patients undergoing surgery. As populations age and surgical interventions become more common, understanding the perioperative care of patients with pre-existing dementia has become an important clinical priority. Dementia is associated with reduced cognitive reserve, chronic neuroinflammation, synaptic dysfunction, blood–brain barrier impairment, neurotransmitter abnormalities, and cerebrovascular dysregulation, all of which may increase vulnerability to perioperative neurological injury. Surgical trauma and anaesthesia trigger systemic inflammatory, metabolic, and haemodynamic responses that may disrupt cerebral homeostasis and contribute to perioperative neurocognitive disorders, including postoperative delirium and delayed neurocognitive recovery. Postoperative delirium is consistently associated with accelerated cognitive and functional decline and may represent an important link between perioperative stress and adverse long-term outcomes. However, despite strong biological plausibility, current clinical evidence does not establish a direct causal relationship between anaesthesia, surgery, and accelerated dementia progression. Interpretation of the available literature is limited by methodological heterogeneity, residual confounding, and the frequent exclusion of patients with established cognitive impairment. This narrative review summarizes the neurobiological mechanisms underlying increased perioperative vulnerability in dementia, critically examines current evidence regarding the effects of anaesthesia and surgery on long-term cognitive and functional outcomes, and discusses practical strategies to reduce perioperative risk. A better understanding of these complex interactions is essential to optimize perioperative care and preserve cognitive function, functional independence, and quality of life in this highly vulnerable patient population. Full article
(This article belongs to the Special Issue Long-Term Outcome of Anesthesia and Surgery)
Show Figures

Figure 1

15 pages, 992 KB  
Article
Subjective Xerostomia and Chairside Salivary Dysfunction in Institutionalized Older Adults: Concordance and Exploratory Derivation of a Five-Item Short Form
by Mădălina Monica Bicheru, Andreea Zamfirescu, Elena Preoteasa, Adrian Iustin Georgevici, Nicolae Vladimir Bicheru and Cristina Teodora Preoteasa
Dent. J. 2026, 14(9), 557; https://doi.org/10.3390/dj14090557 - 2 Sep 2026
Abstract
Background/Objectives: In institutionalized older adults, we examined the concordance between self-reported xerostomia and chairside salivary dysfunction and explored whether a smaller subset of Xerostomia Inventory items could retain comparable screening performance. Methods: This cross-sectional study included institutionalized older adults. The 11-item [...] Read more.
Background/Objectives: In institutionalized older adults, we examined the concordance between self-reported xerostomia and chairside salivary dysfunction and explored whether a smaller subset of Xerostomia Inventory items could retain comparable screening performance. Methods: This cross-sectional study included institutionalized older adults. The 11-item Xerostomia Inventory was compared with a six-marker chairside whole-saliva panel, with all variables scaled 0 (normal) to 1 (pathological). We measured how closely symptoms tracked each objective marker, how well the questionnaire identified hyposalivation, and whether fewer questions could be comparable with the full 11-item inventory. Results: The study included 90 participants, with a mean age of 79.5 years; 55.6% were women. Symptoms tracked every marker in the expected direction (correlation τ-b 0.32 to 0.62). The questionnaire identified objective hyposalivation with an area under the ROC curve of 0.87 (95% CI 0.78–0.96) and substantial chance-corrected agreement (Cohen’s κ 0.69, 95% CI 0.51–0.87). A five-item short form reproduced the objective findings as well as the full questionnaire did (cross-validated R2 0.56 ± 0.03 versus 0.56). Conclusions: In this high-prevalence institutional cohort, self-reported symptoms agreed with graded salivary function more closely than the older discordance literature would suggest, though still within the range of recent studies rather than beyond it. A five-item subset, chosen for its alignment with the objective salivary axis rather than for internal consistency, recovered as much as the full inventory, which points to a short, function-oriented score as a plausible first-stage screen. We would treat this short form as a candidate first-stage screening approach that requires external validation, rather than as a replacement for objective salivary assessment or as a validated replacement for the Xerostomia Inventory. Full article
(This article belongs to the Special Issue Geriatric Dentistry: Innovations, Challenges, and Future Directions)
Show Figures

Graphical abstract

17 pages, 1333 KB  
Article
Hospital Length of Stay and Associated Factors in Patients with Oral Cavity Cancer in Germany: A Retrospective Multicenter Analysis of Inpatient Administrative Data
by Lisa Lotta Cirkel, Isabel Klein and Karel Kostev
Reports 2026, 9(3), 296; https://doi.org/10.3390/reports9030296 - 2 Sep 2026
Abstract
Background: Oral cavity cancer is a clinically relevant subgroup of head and neck malignancies and is associated with substantial treatment burden and healthcare utilization. Hospital length of stay (LOS) is an important indicator of inpatient resource use and complexity of care, yet large [...] Read more.
Background: Oral cavity cancer is a clinically relevant subgroup of head and neck malignancies and is associated with substantial treatment burden and healthcare utilization. Hospital length of stay (LOS) is an important indicator of inpatient resource use and complexity of care, yet large multicenter data from Germany are limited. Methods: This retrospective multicenter analysis used anonymized inpatient administrative data from 49 German hospitals; eligible oral cavity cancer hospitalizations were contributed by 34 of these hospitals. Adult inpatient hospitalizations (≥18 years) with malignant neoplasms of the oral cavity, defined using ICD-10-GM codes C00–C06, recorded between January 1 2019 and 31 December 2024 were included. The primary outcome was hospital LOS in days. Multimorbidity was quantified using the van Walraven-weighted Elixhauser Comorbidity Score. Prolonged hospitalization was defined as LOS ≥ 7 days and LOS ≥ 14 days. Associations between demographic, clinical, and treatment-related variables and LOS were examined using multivariable Poisson regression models. Because overdispersion was present, a negative binomial mixed model was additionally fitted as a sensitivity analysis. To account for inter-hospital variability, hospital was included as a random intercept in all multivariable models. Associations with prolonged LOS were analyzed using multivariable logistic regression models. All analyses were performed at the hospitalization level. Results: A total of 3957 inpatient hospitalizations for oral cavity cancer were included. Mean age was 65.6 years, and 66.2% of hospitalizations involved male patients. The median LOS was 6 days (interquartile range [IQR] 3–13; mean 10.2 days, standard deviation 11.8). Overall, 49.4% of hospitalizations had an LOS ≥ 7 days and 23.5% had an LOS ≥ 14 days. Older age, particularly >80 years, and higher comorbidity burden were associated with longer LOS (adjusted Poisson rate ratio [RR] for age > 80 years 1.17, 95% CI 1.13–1.21; high comorbidity burden RR 1.58, 95% CI 1.54–1.63). Several treatment-related variables, including surgical procedures in the oral and facial region, lymphatic system operations, blood transfusions, and complex intensive care treatment, were associated with prolonged hospitalization (e.g., blood transfusion RR 1.80, 95% CI 1.76–1.85; complex intensive care RR 1.70, 95% CI 1.65–1.75). Chemotherapy-related hospitalizations were associated with shorter LOS. Conclusions: LOS varied substantially across inpatient hospitalizations for oral cavity cancer in Germany. Older age, higher comorbidity burden, and markers of more complex inpatient treatment were associated with extended hospital stay. These findings may help identify hospitalizations at increased risk of prolonged LOS and inform inpatient planning and resource allocation. Full article
(This article belongs to the Section Oncology)
Show Figures

Figure 1

22 pages, 730 KB  
Review
Mitochondria-Targeted Nutraceuticals as Metabolic Adjuncts to Physical Rehabilitation in Older Adults with Sarcopenia or Frailty: A Narrative Review
by Alessio Turco, Lorenzo Lippi, Francesca Uberti, Alessandro de Sire and Marco Invernizzi
Dietetics 2026, 5(4), 55; https://doi.org/10.3390/dietetics5040055 - 2 Sep 2026
Abstract
Age-related skeletal muscle wasting, clinically expressed as sarcopenia and frailty, significantly limits the efficacy of physical rehabilitation due to an underlying cellular bioenergetic decline, mitochondrial dysfunction, and chronic inflammaging. This narrative review synthesizes current physiological and clinical evidence evaluating mitochondria- targeted nutraceuticals as [...] Read more.
Age-related skeletal muscle wasting, clinically expressed as sarcopenia and frailty, significantly limits the efficacy of physical rehabilitation due to an underlying cellular bioenergetic decline, mitochondrial dysfunction, and chronic inflammaging. This narrative review synthesizes current physiological and clinical evidence evaluating mitochondria- targeted nutraceuticals as targeted metabolic adjuvants to physical exercise in older adults. Comprehensive literature searches were executed across PubMed, Web of Science, and Scopus following SANRA guidelines and the SPIDER framework to evaluate functional and bioenergetic outcomes in geriatric cohorts. The findings demonstrate that target-specific biofactors directly impact mitochondrial restrictions: ubiquinol and NAD+ precursors restore electron transport chain efficiency and biogenesis; urolithin A upregulates mitophagy to prevent the cytosolic extrusion of pro-inflammatory mitochondrial DNA, while creatine monohydrate and omega-3 polyunsaturated fatty acids selectively restore downstream myofibrillar anabolic pathways. When translated to specialized clinical settings, including post-fracture orthopedic immobilization, chronic pain syndromes managed, and post-ICU-acquired weakness, these bioenergetic substrates safely mitigate tissue proteolysis and enhance recovery kinetics. In conclusion, structurally integrating biomarker-driven nutritional rehabilitation pathways with tailored exercise protocols provides the precise pro-anabolic microenvironment necessary to overcome anabolic resistance, ultimately shortening recovery timelines and maximizing functional independence in the aging population. Full article
(This article belongs to the Special Issue Nutritional Strategies to Improve Exercise Performance and Recovery)
Show Figures

Figure 1

15 pages, 1034 KB  
Article
Granular Swollen Epithelial Cells in Native Kidney Biopsies: Prevalence, Clinicopathological Associations and Kidney Outcomes
by Naruhiko Uchida, Kenji Tsuji, Hiroyuki Nakanoh, Kazuhiko Fukushima, Shinji Kitamura and Jun Wada
Diagnostics 2026, 16(17), 2822; https://doi.org/10.3390/diagnostics16172822 - 2 Sep 2026
Abstract
Background/Objectives: Granular swollen epithelial cells (GSECs) have been described primarily in mitochondrial cytopathies, in which they are regarded as a characteristic pathological finding that may aid in the diagnosis of mitochondrial dysfunction; however, their prevalence and clinical significance in native kidney disease [...] Read more.
Background/Objectives: Granular swollen epithelial cells (GSECs) have been described primarily in mitochondrial cytopathies, in which they are regarded as a characteristic pathological finding that may aid in the diagnosis of mitochondrial dysfunction; however, their prevalence and clinical significance in native kidney disease remain unclear. We aimed to evaluate the prevalence, clinicopathological associations, and prognostic significance of GSECs in native kidney biopsy specimens. Methods: Among 1165 adults who underwent native kidney biopsy between 2011 and 2024, 501 patients with evaluable medullary tissue were included in this retrospective cohort study. GSECs were defined as enlarged tubular epithelial cells with conspicuous granular cytoplasm in medullary tubules, and cases were classified as GSEC-positive when at least one unequivocal GSEC was identified. Clinical and histopathological characteristics were compared between groups, and kidney outcomes were evaluated using Cox proportional hazards models. Results: The mean baseline eGFR was 60.8 ± 26.3 mL/min/1.73 m2, and the median urinary protein excretion was 1.1 g/gCr. During a median follow-up of 2.3 years, 112 patients (22.3%) reached the composite kidney outcome. GSECs were identified in 18% of native kidney biopsy specimens containing evaluable medullary tissue, and were observed across a broad spectrum of kidney diseases. GSEC positivity was associated with older age and underlying pathological diagnoses but was not associated with baseline kidney function or proteinuria. Kaplan–Meier and multivariable Cox analyses revealed no significant association between GSECs and kidney prognosis. Conclusions: GSECs are not specific to kidney allografts and are observed in a subset of diverse native kidney diseases. Although associated with certain clinical characteristics, no independent association between GSECs and kidney outcomes was observed in this cohort. These findings suggest that GSECs may reflect disease-dependent biological responses to tubular epithelial stress, potentially related to metabolic or mitochondrial alterations, rather than a marker of progressive kidney injury. Full article
(This article belongs to the Special Issue Diagnosis and Treatment of Kidney Disease—2nd Edition)
Show Figures

Figure 1

12 pages, 410 KB  
Article
Turkish Cross-Cultural Adaptation of the BRIEF-MPI in Older Adults with Cancer: Convergent and Discriminative Validity Compared with the G8 and Clinical Frailty Scale
by Sercan On, Haydar Cagatay Yuksel, Semih Sergen Semerci, Ecem Ozdemir, Mustafa Kagan Ozdel and Fatma Ozge Kayhan Kocak
Healthcare 2026, 14(17), 2813; https://doi.org/10.3390/healthcare14172813 - 2 Sep 2026
Abstract
Background: Older adults with cancer represent a heterogeneous population with varying levels of frailty and multidimensional vulnerability. Rapid screening tools are needed to identify patients who may benefit from comprehensive geriatric assessment (CGA). This study aimed to translate and culturally adapt the Brief [...] Read more.
Background: Older adults with cancer represent a heterogeneous population with varying levels of frailty and multidimensional vulnerability. Rapid screening tools are needed to identify patients who may benefit from comprehensive geriatric assessment (CGA). This study aimed to translate and culturally adapt the Brief Multidimensional Prognostic Index (BRIEF-MPI) into Turkish and evaluate its performance in older adults with cancer. Methods: This cross-sectional methodological study included 177 patients aged ≥65 years with solid malignancies. The BRIEF-MPI was translated and culturally adapted using a structured cross-cultural adaptation process. Clinical performance was evaluated by comparison with the G8 screening tool and the Clinical Frailty Scale (CFS). Correlations with frailty-related measures were assessed using Spearman’s rank correlation. Receiver operating characteristic (ROC) analyses were performed to evaluate discriminative performance for identifying CFS-defined frailty. Results: The mean age was 72.5 ± 5.8 years, and 56.5% of participants were women. A positive BRIEF-MPI screening (classes 2–3) was identified in 17.5% of participants, whereas 50.8% screened positive according to the G8. Both instruments were significantly associated with CFS-defined frailty (p<0.001). BRIEF-MPI demonstrated an AUC of 0.883 (95% CI: 0.797–0.969) and higher specificity (91.5%) than the G8 (56.9%), while the G8 showed higher sensitivity (100%). BRIEF-MPI scores were significantly associated with distant metastasis, palliative treatment intent, and poorer ECOG performance status (all p0.001). Conclusions: The Turkish version of the BRIEF-MPI demonstrated good clinical performance for identifying frailty and multidimensional vulnerability in older adults with cancer. Although its overall discriminative ability was comparable to that of the G8, its higher specificity suggests potential utility in clinical settings where reducing false-positive referrals is prioritized. Future prospective and implementation studies are needed to evaluate its clinical utility, prognostic value, and actual impact on geriatric referral pathways in routine oncology practice. Full article
(This article belongs to the Section Clinical Care)
Show Figures

Figure 1

16 pages, 624 KB  
Article
Associations of Physical Activity with One-Year Functional and Cognitive Trajectories Following High-Speed Resistance Training in Older Adults
by Alexandre Duarte Martins, João Paulo Brito, Nuno Batalha, Bruno Gonçalves, Rafael Oliveira and Orlando Fernandes
Sports 2026, 14(9), 386; https://doi.org/10.3390/sports14090386 - 2 Sep 2026
Abstract
Background: Engaging in regular physical activity (PA) after completing structured exercise programmes may contribute to sustaining functional and cognitive gains in older adults over the long term. This study investigated whether different levels of PA during the one-year follow-up were associated with the [...] Read more.
Background: Engaging in regular physical activity (PA) after completing structured exercise programmes may contribute to sustaining functional and cognitive gains in older adults over the long term. This study investigated whether different levels of PA during the one-year follow-up were associated with the preservation of the physical and cognitive gains achieved after a high-speed resistance training (HSRT) intervention lasting 16 weeks. Methods: Thirty-six community-dwelling older adults who had previously finished a supervised 16-week HSRT programme were monitored for one year. According to self-reported PA assessed at the one-year follow-up, participants were allocated to either a light activity group (LAG, n = 20) or a moderate-to-vigorous activity group (MVAG, n = 16). The following tests were used to assess physical function: six-minute walk test (6MWT), chair-stand test, seated medicine ball throw (SMBT), timed up-and-go test (TUG), and handgrip strength (HGS), whereas global cognitive function was assessed with the Mini-Mental State Examination (MMSE). Results: Exploratory between-group comparisons indicated that participants in the MVAG tended to show better chair-stand performance at the six-month (dunb = 0.76 [0.09 to 1.45]) and one-year (dunb = 1.02 [0.34 to 1.74]) assessments. SMBT performance declined similarly in both groups throughout follow-up (LAG: dunb = −0.41 [−0.61 to −0.24]; MVAG: dunb = −0.44 [−0.72 to −0.21]). Although the group × time interaction did not reach statistical significance (p = 0.079, ηp2 = 0.088), exploratory analyses showed that declines in chair-stand and TUG performance occurred mainly in the LAG, pointing to possible patterns related to the maintenance of functional capacity. Cognitive performance decreased post-intervention in both groups, regardless of the PA level. Conclusions: Higher levels of self-reported PA assessed at the one-year follow-up were associated with more favourable trends in lower-limb functional performance. Full article
(This article belongs to the Special Issue Resistance Training for Older Adults)
Show Figures

Figure 1

13 pages, 1014 KB  
Article
Changes in Cardiovascular Health and Functional Fitness Following Multicomponent Exercise Training in Community-Dwelling Older Women
by Sandra Silva-Santos, Paula Rodrigues, Cidália Freitas, Joana Pinto, Raphael José Perrier-Melo and Manoel J. Rios
Physiologia 2026, 6(3), 54; https://doi.org/10.3390/physiologia6030054 - 2 Sep 2026
Abstract
Background: Multicomponent exercise promotes healthy aging, but evidence in community-dwelling older women remains limited. This study examined pre–post changes in functional fitness and cardiovascular health following participation in a six-month multicomponent exercise program. Methods: Thirty-five community-dwelling older women (71.39 ± 6.82 [...] Read more.
Background: Multicomponent exercise promotes healthy aging, but evidence in community-dwelling older women remains limited. This study examined pre–post changes in functional fitness and cardiovascular health following participation in a six-month multicomponent exercise program. Methods: Thirty-five community-dwelling older women (71.39 ± 6.82 years) participated in a quasi-experimental pre–post intervention study. Participants completed supervised multicomponent exercise sessions twice weekly for six months. Anthropometric, cardiovascular, and functional fitness outcomes were assessed before and after the program. Results: Reductions were observed in body mass (68.03 ± 11.39 vs. 66.29 ± 10.02 kg; p < 0.001) and body mass index (26.56 ± 3.71 vs. 25.90 ± 3.22 kg·m−2; p < 0.05). Lower post-test values were also observed for systolic blood pressure (125 ± 9 vs. 121 ± 10 mmHg; p = 0.026), resting heart rate (85 ± 12 vs. 77 ± 11 bpm; p = 0.008), and double product (10,359 ± 1899 vs. 9701 ± 1705 mmHg·bpm; p = 0.027). Handgrip strength was higher at post-test in both the dominant hand (20.98 ± 5.47 vs. 22.53 ± 6.31 kgf; p = 0.007) and non-dominant hand (19.23 ± 4.99 vs. 21.20 ± 5.61 kgf; p < 0.001). Functional aerobic capacity was also higher at post-test (95.74 ± 21.35 vs. 110.41 ± 22.86 steps; p < 0.001), while flexibility values were higher in the left Chair Sit-and-Reach Test (−15.92 ± 10.48 vs. −12.97 ± 10.91 cm; p = 0.001) and left Back Scratch Test (−3.65 ± 6.82 vs. 4.32 ± 7.83 cm; p < 0.001). Conclusions: Participation in a twice-weekly multicomponent exercise program for six months was associated with favorable pre–post changes in functional fitness and cardiovascular health in community-dwelling older women. Full article
(This article belongs to the Special Issue Exercise Physiology and Biochemistry: 4th Edition)
Show Figures

Figure 1

10 pages, 534 KB  
Article
Baseline Eating Behaviors and Responsiveness to TelePhysio in Older Patients with Type 2 Diabetes: An Exploratory Secondary Analysis of the TelePhysioT2D Trial
by Hiroaki Kataoka, Takuo Nomura, Hiroyuki Oka and Yukio Ikeda
Diabetology 2026, 7(9), 170; https://doi.org/10.3390/diabetology7090170 - 2 Sep 2026
Abstract
Background/Objectives: Telerehabilitation for physiotherapy programs (TelePhysio) has been shown to improve knee extension force (KEF) in older patients with type 2 diabetes mellitus (T2DM), but factors associated with responsiveness remain unclear. This exploratory secondary analysis investigated whether baseline eating behaviors modified the effectiveness [...] Read more.
Background/Objectives: Telerehabilitation for physiotherapy programs (TelePhysio) has been shown to improve knee extension force (KEF) in older patients with type 2 diabetes mellitus (T2DM), but factors associated with responsiveness remain unclear. This exploratory secondary analysis investigated whether baseline eating behaviors modified the effectiveness of TelePhysio in KEF. Methods: This secondary analysis included 74 older patients with T2DM enrolled in a randomized controlled trial. The participants were assigned to the TelePhysio (n = 39) or non-intervention group (n = 35). Baseline eating behaviors were assessed using an Eating Behavior Questionnaire. Multiple regression analysis was performed using 6-month KEF as the dependent variable, adjusting for baseline KEF, age, sex, body mass index, diabetic polyneuropathy, intervention group, baseline eating behavior score, and their interactions. The original trial was prospectively registered with the University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR; UMIN000024416; registered on 15 October 2016). Results: A significant interaction was found between the intervention group and baseline eating behavior score (B = −0.0064, p = 0.0352). Estimated TelePhysio effects on eating behavior scores corresponding to mean − 1 standard deviation (SD), mean, and mean + 1 SD were +0.36, +0.12, and −0.12 Nm/kg, respectively. None of the seven domain-specific group-by-domain interactions reached statistical significance. Sensitivity analyses using KEF changes showed a similar directional trend but were not statistically significant (p = 0.2913). Conclusions: Baseline eating behaviors may be associated with differential responsiveness to TelePhysio in older adults with T2DM. The estimated effect of TelePhysio on KEF was smaller at higher baseline Eating Behavior Questionnaire scores. These findings should be cautiously interpreted because the interaction was not confirmed using sensitivity analysis regarding changes in the KEF. Full article
(This article belongs to the Section Treatment, Intervention and Care of Diabetes)
Show Figures

Figure 1

26 pages, 981 KB  
Article
The Impact of Nursing Home Environmental Expectation Gaps on Residential Adaptation Among Older Adults: Evidence from Inclusive Nursing Homes in Changchun, China
by Boyu Du, Hang Zhang, He Liu, Wanying Qin, Xiaolong Zhao and Jinghao Zhao
Buildings 2026, 16(17), 3489; https://doi.org/10.3390/buildings16173489 - 1 Sep 2026
Abstract
This study examined how environmental expectation gaps, defined as discrepancies between older adults’ expectations before admission and their actual experiences after admission, are associated with residential adaptation in nursing homes. Survey data from 613 residents of six public and private inclusive nursing homes [...] Read more.
This study examined how environmental expectation gaps, defined as discrepancies between older adults’ expectations before admission and their actual experiences after admission, are associated with residential adaptation in nursing homes. Survey data from 613 residents of six public and private inclusive nursing homes in Changchun, China, were analyzed using structural equation modeling and bias-corrected bootstrapping. Expectation gaps in safety and mobility convenience, privacy and autonomy, environmental comfort, and spatial cognition and familiarity were significantly associated with emotional adaptation, with spatial cognition and familiarity showing the strongest relationship. Support for activities and social interaction was positively associated with relationship formation but negatively associated with communal-living adaptation. Residential adaptation followed a sequential process from emotional adaptation to relationship formation, acceptance of institutional living, and adaptation to communal living. Bootstrap analysis further showed that several environmental expectation gaps were indirectly associated with later adaptation outcomes through this sequential process, with some direct and indirect relationships operating in opposite directions. These findings demonstrate that environmental expectation gaps are associated with residential adaptation through differentiated and interconnected pathways, extending nursing home evaluation beyond facility conditions and satisfaction alone. Full article
(This article belongs to the Special Issue Age-Friendly Built Environment and Sustainable Architectural Design)
Show Figures

Figure 1

20 pages, 680 KB  
Review
Acute Myeloid Leukemia in Older Adults: A Comprehensive Narrative Review of Risk Stratification and Treatment Advances
by Ahmed S. Mohamed, Shraboni Dey, Shibhani Rajanna, Marina Basta, Shareif Abdelwahab, Maggie James, Mohammed A. Saafan, Tarneem Deyab and Sameh Elias
Hemato 2026, 7(3), 30; https://doi.org/10.3390/hemato7030030 - 1 Sep 2026
Abstract
Acute myeloid leukemia (AML) is predominantly a disease of older adults, with a median age at diagnosis of 68–72 years. Management in this population is complicated by adverse cytogenetic and molecular features, higher rates of secondary disease, and patient-specific factors such as comorbidity [...] Read more.
Acute myeloid leukemia (AML) is predominantly a disease of older adults, with a median age at diagnosis of 68–72 years. Management in this population is complicated by adverse cytogenetic and molecular features, higher rates of secondary disease, and patient-specific factors such as comorbidity and frailty. This narrative review synthesizes the current evidence on risk stratification and treatment of AML in adults aged 60 years and older, with dedicated attention to patients aged 60–75 (“fit” older adults) and those older than 75, including octogenarians. The VIALE-A trial established venetoclax plus azacitidine as standard of care for patients ineligible for intensive chemotherapy (composite complete remission 66.4%; median overall survival 14.7 vs. 9.6 months with azacitidine alone). For fit adults aged 60–75, the choice between intensive chemotherapy and venetoclax-based regimens remains under active investigation, with emerging randomized data suggesting comparable outcomes and a possible advantage for venetoclax-based approaches in adverse-risk disease. Risk stratification has evolved beyond the 2022 European LeukemiaNet (ELN) classification, which was developed in intensively treated cohorts; the 2024 ELN genetic risk classification for less-intensive therapy now provides a framework specific to this population. TP53-mutated AML, including multi-hit disease, remains the dominant unmet need across all treatment modalities. Advances in reduced-intensity conditioning have expanded transplant eligibility into the seventh and eighth decades, and molecularly targeted approaches, including FLT3, IDH1/2, and menin inhibitors, are reshaping frontline and relapsed/refractory therapy. This review covers epidemiology, risk stratification, treatment stratified by age, fitness, and genetic subgroup, the role of transplantation and maintenance therapy, and the limitations of the current evidence base for this heterogeneous population. Full article
17 pages, 1925 KB  
Article
Low-Sample Input miRNA Profiling in Extracellular Vesicles-Enriched Plasma Fractions from Older Adults With/out Cognitive Impairment
by Arianna Consiglio, Ylenia Antonacci, Claudia Lograno, Claudia Chiapparino, Katia Pinto, Apollonia Tullo and Maria Liguori
Int. J. Mol. Sci. 2026, 27(17), 7838; https://doi.org/10.3390/ijms27177838 - 1 Sep 2026
Abstract
The RNA cargo of extracellular vesicles (EVs) has been investigated to search for circulating biomarkers possibly associated with a given disease. In this direction, vesicular small RNAs like microRNAs (miRNAs) showed great potential e.g., in monitoring neurodegenerative diseases and their clinical signs. In [...] Read more.
The RNA cargo of extracellular vesicles (EVs) has been investigated to search for circulating biomarkers possibly associated with a given disease. In this direction, vesicular small RNAs like microRNAs (miRNAs) showed great potential e.g., in monitoring neurodegenerative diseases and their clinical signs. In this exploratory cross-sectional study, we looked for miRNAs possibly associated with age-related cognitive impairment. Using a high processivity and sensitive OpenArray technology, we analyzed the expression of 223 miRNAs in plasmatic total EV-enriched fractions from 43 subjects older than 65 years who received neuropsychological examination. In a smaller cohort of 17 subjects, we verified any miRNA discrepancies between EV-associated and unfractionated plasma samples. A set of candidate miRNAs showed reduced expression in EV-associated fractions from cognitively impaired (n. 12) compared to cognitively preserved (n. 23) subjects. In particular, the expression of 15 of them (miR-106b-5p, miR-128-3p, miR-15a-5p, miR-16-5p, miR-17-5p, miR-191-5p, miR-192-5p, miR-199a-3p, miR-221-3p, miR-222-3p, miR-223-3p, miR-22-3p, miR-26a-5p, miR-335-5p) correlated with the MMSE score. Pathways of neurodegeneration (ND), such as PI3K-Akt, Ras/MAPK, and Wnt signaling, resulted significantly involved. Furthermore, 18 miRNAs were implicated in metal ion binding processes, thus supporting the key role of this molecular mechanism in ND-associated cognitive dysfunction. The paired analysis of EV-plasma samples reported the overall upregulation of most of the 223 miRNAs in plasma samples, whereas miR-425-5p, miR-5035-3p, miR-192-5p, miR-181a-3p, miR-338-3p and miR-1271-5p were almost stable in the two fractions and miR-205-5p and miR-28-5p were significantly upregulated in EVs compared to plasma. In our view, these findings support the potential relevance of vesicular-associated miRNAs as candidates of age-related cognitive dysfunctions, although for clinical practice some methodological issues may arise, i.e., the feasibility of total EVs extraction. Further confirmations are needed, e.g., the complete characterization of EVs’ cargo and origin, and validation in larger samples. Full article
Show Figures

Figure 1

13 pages, 670 KB  
Article
Associations of Smartphone Ownership with Health-Related Quality of Life and Social Connectedness Among Older Japanese Adults: A Quantile Regression Analysis
by Takashi Kawano and Goro Moriki
Soc. Sci. 2026, 15(9), 594; https://doi.org/10.3390/socsci15090594 - 1 Sep 2026
Abstract
Loneliness and social isolation in later life are important public health concerns, and information and communication technology (ICT) may support everyday functioning and social participation among older adults. However, mean-based analyses may obscure variation in associations across outcome distributions. Using quantile regression, we [...] Read more.
Loneliness and social isolation in later life are important public health concerns, and information and communication technology (ICT) may support everyday functioning and social participation among older adults. However, mean-based analyses may obscure variation in associations across outcome distributions. Using quantile regression, we examined the associations of smartphone ownership with health-related quality of life (SF-36v2: PCS, MCS, and RCS) and social connectedness (LSNS-6) among 919 community-dwelling senior club members in a regional Japanese city; regression analyses used 839 complete cases. Coefficients were estimated at the 20th, 40th, 60th, and 80th conditional quantiles. Smartphone ownership was associated with RCS at the 20th (β = 3.72), 40th (β = 4.42), and 60th (β = 2.21) quantiles, but not at the 80th quantile (β = 1.41), and coefficients differed significantly across quantiles (F(3, 3353) = 3.97, p = 0.008). The 20th-, 40th-, and 60th-quantile coefficients and the Wald test remained significant after Holm adjustment. Smartphone ownership was not associated with PCS, MCS, or LSNS-6 at any quantile. The smartphone ownership × gender interaction for RCS was non-significant at all quantiles, providing no evidence that this association differed by gender. These findings indicate that the association between smartphone ownership and role/social functioning varies across its conditional distribution. Because the study is cross-sectional and actual smartphone use was not measured, causal interpretation is not warranted. Longitudinal studies measuring patterns of smartphone use are needed. Full article
27 pages, 4306 KB  
Article
Behavioral Barriers to Digital Health and Conditions of Digital Resilience Among Older Adults: Evidence from China
by Yu Ren, Weihua Yang and Wan Li
Behav. Sci. 2026, 16(9), 1550; https://doi.org/10.3390/bs16091550 - 1 Sep 2026
Abstract
As health services shift to digital delivery, older adults face practical online risks, including operational errors, difficulty interpreting clinical information, unclear privacy consent procedures, and telecommunications fraud. Existing empirical work mostly adopts questionnaire and interview designs to document older adults’ real-world digital usage, [...] Read more.
As health services shift to digital delivery, older adults face practical online risks, including operational errors, difficulty interpreting clinical information, unclear privacy consent procedures, and telecommunications fraud. Existing empirical work mostly adopts questionnaire and interview designs to document older adults’ real-world digital usage, yet few studies systematically analyze policy documents as an external intervention system and assess how they address four core usage barriers: limited digital proficiency, constrained service access, weak sustained participation, and individualized online safety threats. This paper analyzes 1008 policy records extracted from the Peking University Legal Database covering 2007–2025, and develops a four-dimensional analytical framework split into B1 (Digital Capacity and Age-Friendly Support), B2 (Digital Health Management Support), B3 (Home- and Community-Based Care Support), and B4 (Institutional Care and Risk Governance). The analytical toolkit combines a Capability–Opportunity–Motivation–Behavior (COM-B) diagnostic model, an M1–M4 intervention-mechanism coding protocol, Latent Dirichlet Allocation (LDA) topic modeling, and two indices: the Digital Adaptation Policy Orientation Index (DAPOI) and the Behavioral Intervention Diversity Index (BIDI). Coding outputs reveal a pronounced structural imbalance in policy allocation for older adults’ digital health in China: community and institutional governance clauses (B3, B4) dominate the corpus, while person-centred support including one-on-one operational coaching, clinical data interpretation guidance and offline manual backup channels accounts for a marginal share of all coded entries (B1, B2). Age-friendly digital policies issued circa 2020 serve primarily short-term emergency adjustments instead of permanent institutional arrangements. Built on full-text policy coding outputs, this work defines policy-supported digital resilience as a holistic protective system formed by coordinated institutional clauses. Every result reported is sourced exclusively from supply-side policy records, which provides policy-level evidence for subsequent behavioral research on older adults’ digital risk management and digital welfare construction. Full article
Show Figures

Figure 1

Back to TopTop