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20 pages, 498 KB  
Article
Fostering Action Competence Through Emancipatory, School-Based Environmental Projects: A Bildung Perspective
by Suchawadee Ketchanok and Jeerawan Ketsing
Educ. Sci. 2025, 15(12), 1706; https://doi.org/10.3390/educsci15121706 - 17 Dec 2025
Viewed by 457
Abstract
Although much research in environmental and sustainability education has focused on knowledge and awareness, fewer studies have examined how school-based projects can foster young learners’ capacity for action. This study investigates how emancipatory, school-based environmental projects can foster young learners’ foundational capacities for [...] Read more.
Although much research in environmental and sustainability education has focused on knowledge and awareness, fewer studies have examined how school-based projects can foster young learners’ capacity for action. This study investigates how emancipatory, school-based environmental projects can foster young learners’ foundational capacities for contributing to a more sustainable and caring future. Grounded in the Bildung perspective and the action competence framework, a 16-week intervention was implemented with Grade 8 students who collaboratively identified and addressed authentic environmental issues—such as waste mismanagement, sanitation concerns, and safety risks—within their school community. Using a concurrent mixed-methods design, quantitative data from the Student Action Competence Questionnaire were integrated with qualitative evidence from worksheets and reflective journals. Results show consistent improvement across all dimensions of action competence, particularly in democratic collaboration and students’ willingness to take shared responsibility for environmental well-being. Qualitative findings reveal the development of critical reflection, co-creation with school stakeholders, and a growing sense of social responsibility, as students engaged in activities ranging from redesigning waste systems to proposing improvements through official communication channels. Rather than focusing on large-scale environmental outcomes, the projects cultivated everyday practices of care, participation, and ethical awareness—key dispositions for inspiring long-term change toward a greener and more sustainable future. The study highlights how context-based, dialogic learning can empower students as emerging environmental citizens within their immediate communities. Full article
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15 pages, 289 KB  
Article
Primary and Secondary School Textbooks in Official and Minority Languages in North Macedonia: Challenges of the Digital Era
by Pavel Falaleev
Educ. Sci. 2025, 15(12), 1684; https://doi.org/10.3390/educsci15121684 - 14 Dec 2025
Viewed by 760
Abstract
The article discusses the challenges faced by primary and secondary school students in North Macedonia, focusing on the availability of textbooks for those receiving instruction in minority languages. Although some materials are available for download on the E-učebnici platform operated by the Ministry [...] Read more.
The article discusses the challenges faced by primary and secondary school students in North Macedonia, focusing on the availability of textbooks for those receiving instruction in minority languages. Although some materials are available for download on the E-učebnici platform operated by the Ministry of Education and Science, this does not encompass all didactic resources required for instruction. Cataloging of the materials on the platform reveals that while electronic versions of many textbooks in Macedonian are freely accessible, students studying in Albanian (a co-official language) and minority languages such as Turkish, Bosnian, and Serbian have considerably fewer digital resources. The data indicate that disparities begin from the fifth grade and widen in higher grades, with Bosnian- and Serbian-speaking students particularly disadvantaged. In vocational education, Macedonian-speaking students have the broadest access to electronic materials, while Albanian and especially Turkish speakers have far fewer options, and no digital textbooks are available in Serbian. The analysis demonstrates that a semi-official hierarchy of languages persists within North Macedonia’s educational system, privileging Macedonian and, to a lesser extent, Albanian, while marginalizing other minority languages both institutionally and technologically. The article concludes by outlining the challenges and implications of implementing digital resources as a means to address linguistic inequality in education. Full article
(This article belongs to the Special Issue Innovation and Design in Multilingual Education)
17 pages, 594 KB  
Article
Does Daytime Sleepiness Moderate the Relationship Between Working Memory and Academic Performance in Schoolchildren? A Pilot Study
by Sergey Malykh and Valeriia Demareva
Clocks & Sleep 2025, 7(4), 57; https://doi.org/10.3390/clockssleep7040057 - 8 Oct 2025
Viewed by 1662
Abstract
Academic performance in adolescence is influenced by both cognitive capacity and physiological factors such as sleepiness. However, the interaction between these dimensions remains understudied. This pilot study examined whether daytime sleepiness moderates the relationship between working memory and academic achievement in a sample [...] Read more.
Academic performance in adolescence is influenced by both cognitive capacity and physiological factors such as sleepiness. However, the interaction between these dimensions remains understudied. This pilot study examined whether daytime sleepiness moderates the relationship between working memory and academic achievement in a sample of 601 schoolchildren aged 11 to 17 years. Participants completed a digital visuospatial working memory task and self-reported their daytime sleepiness using the Pediatric Daytime Sleepiness Scale (PDSS). Academic performance was assessed through official grades in Mathematics, Language, and Literature. Regression analyses showed that working memory (total score and average reaction time) and daytime sleepiness were independent predictors of academic performance. These findings support our hypotheses that cognitive and physiological factors each contribute to school success. However, no significant moderation effects were found in the full sample. Subgroup analyses revealed that working memory predicted academic outcomes only among students with normal sleepiness levels, whereas in high-sleepiness students, cognitive predictors lost significance and PDSS scores emerged as the dominant predictor. These results suggest that elevated daytime sleepiness can undermine the positive impact of working memory on academic performance. The findings highlight the importance of assessing both cognitive skills and physiological readiness when evaluating students. They also suggest that sleep-focused interventions may improve learning outcomes, especially during adolescence. Full article
(This article belongs to the Section Human Basic Research & Neuroimaging)
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14 pages, 477 KB  
Article
Student–Teacher Relationship and Mathematics Achievement: Comparative Insights from Students With and Without Diverse Learning Needs
by Georgios Polydoros, Alexandros-Stamatios Antoniou and Athanasios Drigas
Psychol. Int. 2025, 7(3), 77; https://doi.org/10.3390/psycholint7030077 - 7 Sep 2025
Viewed by 4120
Abstract
The student–teacher relationship is widely acknowledged as a key factor influencing both academic achievement and emotional well-being. In Grade 12 mathematics, where academic demands and pressure are particularly high, the quality of this relationship can significantly affect students’ performance. This study investigates how [...] Read more.
The student–teacher relationship is widely acknowledged as a key factor influencing both academic achievement and emotional well-being. In Grade 12 mathematics, where academic demands and pressure are particularly high, the quality of this relationship can significantly affect students’ performance. This study investigates how students with different learning profiles perceive their relationship with their mathematics teacher and how this relationship correlates with their academic outcomes. Grounded in sociocultural perspectives on learning and psychological theories of motivation, the study explores dimensions such as closeness, support, and conflict. The sample included 120 Grade 12 students (aged 17–18) from seven state-funded high schools in Attica, Greece, evenly divided into two groups based on learning characteristics. Data were collected through a structured questionnaire and official school records of mathematics achievement. Findings revealed clear and statistically significant differences between the groups. Students who reported more positive relational experiences also demonstrated higher academic achievement. Across the full sample, stronger relational bonds were associated with better academic performance, while conflict was linked to lower achievement. This study makes a novel contribution by offering a comparative perspective on how the student–teacher relationship functions in high-stakes mathematics education. The results underscore the importance of fostering supportive and inclusive classroom environments, and they highlight the need for targeted professional development to help teachers build effective relationships with diverse learners. Full article
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13 pages, 511 KB  
Article
Depressive and Anxiety Symptoms Among Patients with Asbestos-Related Diseases in Korea
by Min-Sung Kang, Mee-Ri Lee and Young Hwangbo
Toxics 2025, 13(8), 703; https://doi.org/10.3390/toxics13080703 - 21 Aug 2025
Cited by 1 | Viewed by 1024
Abstract
Asbestos-related diseases (ARDs), including malignant mesothelioma, asbestos-related lung cancer, and asbestosis, are known for their long latency periods and poor prognoses. Although the physical effects of ARDs have been widely studied, limited research has examined the psychological burden faced by affected individuals. This [...] Read more.
Asbestos-related diseases (ARDs), including malignant mesothelioma, asbestos-related lung cancer, and asbestosis, are known for their long latency periods and poor prognoses. Although the physical effects of ARDs have been widely studied, limited research has examined the psychological burden faced by affected individuals. This study investigated depressive and anxiety symptoms among 275 patients officially recognized as asbestos victims in Korea. Mental health was assessed using the Korean version of the Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and the Hospital Anxiety and Depression Scale (HADS). The analysis revealed that the mean ± standard deviation of depression and anxiety levels among patients with asbestos-related diseases were 8.06 ± 6.27 for PHQ-9, 6.02 ± 5.64 for GAD-7, 7.09 ± 5.44 for HADS-A, and 8.41 ± 5.47 for HADS-D. Patients with asbestosis had higher levels of depressive and anxiety symptoms than those with malignant mesothelioma or lung cancer, with symptom severity increasing alongside asbestosis grade. When compared with national data from the 2020–2021 Korea National Health and Nutrition Examination Survey (KNHANES), PHQ-9 and GAD-7 scores among ARD patients, particularly those with Grade 1 asbestosis, were higher than the scores reported for all major cancer types. These findings highlight the substantial psychological distress experienced by individuals with ARDs and emphasize the urgent need for targeted mental health interventions in this population. Full article
(This article belongs to the Section Human Toxicology and Epidemiology)
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22 pages, 2974 KB  
Article
Determination of Soft Partitioning Thresholds for Reservoir Drought Warning Levels Under Socio-Hydrological Drought
by Yewei Liu, Xiaohua Xu, Rencai Lin, Weifeng Yang, Peisheng Yang, Siying Li and Hongxin Wang
Agriculture 2025, 15(13), 1408; https://doi.org/10.3390/agriculture15131408 - 30 Jun 2025
Cited by 1 | Viewed by 842
Abstract
The failure of traditional drought indices to capture the dynamic supply–demand imbalance in socio-hydrological systems hinders proactive water management and necessitates novel assessment frameworks. The reservoir drought warning water level, serving as a dynamic threshold indicating supply–demand imbalance, provides a critical basis for [...] Read more.
The failure of traditional drought indices to capture the dynamic supply–demand imbalance in socio-hydrological systems hinders proactive water management and necessitates novel assessment frameworks. The reservoir drought warning water level, serving as a dynamic threshold indicating supply–demand imbalance, provides a critical basis for drought early warning. From a socio-hydrological drought perspective, this study develops a framework for determining staged and graded soft partition thresholds for reservoir drought warning water levels, encompassing three key stages: water stress analysis, phase classification, and threshold determination. First, water demands for the ecological, agricultural, and domestic sectors were quantified based on hydrological analysis and official operational rules. Second, an optimized KPCA-Fisher model delineated the intra-annual supply–demand dynamics into distinct periods. Thirdly, the soft partition thresholds were formulated by coupling these multi-sectoral demands with water deficit rates using a triangular membership function. Applied to the Xianan Reservoir, the framework yielded distinct drought warning thresholds for the identified main flood, critical demand, and dry seasons. Validation against historical droughts (2019 and 2022) confirmed that these soft thresholds more accurately tracked the drought evolution process compared to traditional hard partitions. Furthermore, a sensitivity analysis identified the ecological water demand methodology as a key factor influencing the thresholds, particularly during the critical demand period. The proposed framework for determining staged and graded reservoir drought warning water levels better reflects the complexity of socio-hydrological systems and provides a scientific basis for refined reservoir drought early warnings and management under changing environments. Full article
(This article belongs to the Section Artificial Intelligence and Digital Agriculture)
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22 pages, 548 KB  
Article
Readability Formulas for Elementary School Texts in Mexican Spanish
by Daniel Fajardo-Delgado, Lino Rodriguez-Coayahuitl, María Guadalupe Sánchez-Cervantes, Miguel Ángel Álvarez-Carmona and Ansel Y. Rodríguez-González
Appl. Sci. 2025, 15(13), 7259; https://doi.org/10.3390/app15137259 - 27 Jun 2025
Viewed by 1725
Abstract
Readability formulas are mathematical functions that assess the ‘difficulty’ level of a given text. They play a crucial role in aligning educational texts with student reading abilities; however, existing models are often not tailored to specific linguistic or regional contexts. This study aims [...] Read more.
Readability formulas are mathematical functions that assess the ‘difficulty’ level of a given text. They play a crucial role in aligning educational texts with student reading abilities; however, existing models are often not tailored to specific linguistic or regional contexts. This study aims to develop and evaluate two novel readability formulas specifically designed for the Mexican Spanish language, targeting elementary education levels. The formulas were trained on a corpus of 540 texts drawn from official elementary-level textbooks issued by the Mexican public education system. The first formula was constructed using multiple linear regression, emulating the structure of traditional readability models. The second was derived through genetic programming (GP), a machine learning technique that evolves symbolic expressions based on training data. Both approaches prioritize interpretability and use standard textual features, such as sentence length, word length, and lexical and syntactic complexity. Experimental results show that the proposed formulas outperform several well-established Spanish and non-Spanish readability formulas in distinguishing between grade levels, particularly for early and intermediate stages of elementary education. The GP-based formula achieved the highest alignment with target grade levels while maintaining a clear analytical form. These findings underscore the potential of combining machine learning with interpretable modeling techniques and highlight the importance of linguistic and curricular adaptation in readability assessment tools. Full article
(This article belongs to the Special Issue Machine Learning and Soft Computing: Current Trends and Applications)
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26 pages, 13044 KB  
Review
SIU-ICUD: Localized Prostate Cancer: Pathological Factors That Influence Outcomes and Management
by Gladell P. Paner, Eva M. Compérat, Samson W. Fine, James G. Kench, Glen Kristiansen, Rajal B. Shah, Steven Christopher Smith, John R. Srigley, Geert J. L. H. van Leenders, Murali Varma, Ming Zhou and Mahul B. Amin
Soc. Int. Urol. J. 2025, 6(3), 41; https://doi.org/10.3390/siuj6030041 - 7 Jun 2025
Cited by 1 | Viewed by 3774
Abstract
Background/Objectives: Pathological factors are integral in the risk stratification and management of localized prostate cancer. In recent years, there has been an upsurge of studies that uncovered novel approaches and have refined prognostic factors for prostate cancer in needle biopsy and radical prostatectomy [...] Read more.
Background/Objectives: Pathological factors are integral in the risk stratification and management of localized prostate cancer. In recent years, there has been an upsurge of studies that uncovered novel approaches and have refined prognostic factors for prostate cancer in needle biopsy and radical prostatectomy (RP) specimens. Methods: We conducted a review of literature and summarized the significant recent updates on pathological factors for localized prostate cancer. Results: Innovative factors derived from the traditional Gleason grading, such as the extent of Gleason pattern 4 and presence of cribriform pattern are now recognized to significantly improve discrimination of outcome. The components and rules of Gleason grading themselves underwent modifications, and the subsequent prognostic grouping of the different grades (Grade group) have resulted in enhanced stratification of behavior more meaningful in management decision. The approaches for grade reporting in systematic or targeted needle biopsies and in RP with multifocal cancers are also being optimized. Newer tumor growth pattern-based factors such as intraductal carcinoma and atypical intraductal proliferation can have ramifications in management, especially in the background of low to intermediate risk prostate cancers. Gleason grade considerations in the different post-treatment settings and for de novo and residual prostate cancers with varying treatment effects have also been explicated. Likewise, the application of more traditional factors in tumor extent and perineural invasion in biopsy, or positive surgical margin in RP, have also evolved. Conclusions: Some of these newer pathological factors are now officially recommended in standardized pathology reporting protocols and are applied in the management decision for localized prostate cancer. Full article
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18 pages, 1553 KB  
Article
Improvement in the Usability of Meat Inspection Findings for Swine Herd Health Management
by Darko Maric, Sebastian Vetter-Lang, Johannes Klinger, Nikolaus Böhm, Karin Schwaiger and Annemarie Käsbohrer
Animals 2025, 15(5), 688; https://doi.org/10.3390/ani15050688 - 26 Feb 2025
Viewed by 1312
Abstract
Data from post-mortem inspections conducted using official controls on the meat production of slaughtered pigs are generally considered valuable for identifying herd health issues and ensuring meat safety. However, several studies highlighted that a multi-stage assessment of lung changes would provide more useful [...] Read more.
Data from post-mortem inspections conducted using official controls on the meat production of slaughtered pigs are generally considered valuable for identifying herd health issues and ensuring meat safety. However, several studies highlighted that a multi-stage assessment of lung changes would provide more useful information on animal health than the implemented binary (yes/no) recording. For this purpose, a new scheme was developed and subsequently used by trained official veterinarians at four slaughterhouses in Austria. Implementation of the multi-stage assessment was carried out in parallel with the conventional assessment, and data collected from both schemes were analyzed and compared to evaluate effectiveness. The analysis of the data (n = 20,345) showed that the most common alteration was low-grade (28.4%), followed by moderate-grade (11.3%,) and then high-grade pneumonia (5.2%). In the case of pleurisy, 88.9% of the carcasses showed no alterations of the pleura, and 11.1% had pathological changes (low-grade pleurisy = 4.7%, moderate-grade pleurisy = 2.7%, high-grade pleurisy = 3.7%). Analysis of the results showed a strong heterogeneity of the frequency of alterations between the batches reflecting various underlying animal health issues. Among the influencing factors, the origin of the pigs had the greatest influence. The project demonstrated that the new evaluation can be carried out easily with no extra time effort once staff are trained and the technological platform for reporting is adapted. The more detailed information ensures more useful feedback is provided to the farmers and supervising veterinarians, thereby ensuing animal welfare and contributing to sustainable, improved animal husbandry. Full article
(This article belongs to the Section Animal System and Management)
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11 pages, 221 KB  
Article
Very Low Energy Ketogenic Therapy (VLEKT), Not Only a Price Matter: A Comparison Study on Average Costs of VLEKT with Fresh Foods and Replacement Meals
by Giuseppe Annunziata, Ludovica Verde, Andrea Falco, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri and Luigi Barrea
Nutrients 2025, 17(3), 422; https://doi.org/10.3390/nu17030422 - 24 Jan 2025
Cited by 5 | Viewed by 3104
Abstract
Background: Obesity is constantly growing worldwide, representing a serious concern also for healthcare costs. Current anti-obesity pharmacological strategies, although effective, represent a significant cost for the patient. Similarly, very low energy ketogenic therapy (VLEKT) protocols with replacement meals also have high costs. Objectives: [...] Read more.
Background: Obesity is constantly growing worldwide, representing a serious concern also for healthcare costs. Current anti-obesity pharmacological strategies, although effective, represent a significant cost for the patient. Similarly, very low energy ketogenic therapy (VLEKT) protocols with replacement meals also have high costs. Objectives: The objective of this study was to estimate the average costs of a VLEKT protocol with replacement meals compared with those of isocaloric diets with fresh foods. Methods: VLEKTs with replacement meals and fresh foods were developed considering an ideal young woman and man with grade II obesity (BMI ≥ 35.0 kg/m2). The costs of the individual fresh foods were extrapolated from official Italian databases. The costs of replacement meals were obtained by consulting the catalogs of three companies specialized in VLEKTs operating in Italy. Results: On a monthly basis, VLEKT with fresh food had an average cost of EUR 253.44 and EUR 295.67, while VLEKT with replacement meals had an average cost of EUR 434.91 and EUR 535.99, for the woman and man, respectively. Conclusions: Although more expensive than a common diet, VLEKT should be seen not only as a dietary method for losing weight, but as a non-pharmacological, medicalized nutritional therapy, useful for managing various conditions, even those not directly related to obesity. Like a drug therapy, VLEKT requires the use of specific products that entail a higher cost, to be borne by the patient, but whose benefits should be emphasized, which go beyond weight loss and concern general health, thus considering them as a targeted nutritional strategy. Full article
(This article belongs to the Special Issue Ketogenic Diet and Mediterranean Diet as Medical Nutrition Therapies)
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20 pages, 417 KB  
Article
ChatGPT in Computer Science Education: A Case Study on a Database Administration Course
by Daniel López-Fernández and Ricardo Vergaz
Appl. Sci. 2025, 15(2), 985; https://doi.org/10.3390/app15020985 - 20 Jan 2025
Cited by 3 | Viewed by 6260
Abstract
GenAI tools like ChatGPT have changed the educational landscape, and empirical experiences are needed to better understand how to use them to their fullest potential. This article empirically explores the usage of ChatGPT 3.5 in database administration education through a case study conducted [...] Read more.
GenAI tools like ChatGPT have changed the educational landscape, and empirical experiences are needed to better understand how to use them to their fullest potential. This article empirically explores the usage of ChatGPT 3.5 in database administration education through a case study conducted with 40 computer science students. Specifically, it inspects how widespread the use of ChatGPT is and students’ perceptions of this tool, how prior knowledge on a topic affects the use of ChatGPT, and the relationship between the usage of ChatGPT and success in solving practical problems. The student’s grades in a computer practical exam, a set of theoretical tests to assess progression in knowledge acquisition, and a comprehensive questionnaire are employed as research instruments. The obtained results indicate that students use ChatGPT moderately but more frequently than traditional internet learning resources such as official documentation, Stack Overflow or googling. However, the usage is uneven among students, and those who end up getting better grades use ChatGPT more. Beyond prompting skills, one of the elements that is key to the students’ productive use of this tool is their prior knowledge about database administration. This article concludes that ChatGPT is an excellent educational instrument in the context of database administration and that in order to use it properly, it is necessary for students to have good prompting skills as well as a sound theoretical basis. Training students in the use of GenAI tools like ChatGPT, for example, with a guided practice strategy where prompting and conducted step-by-step practice are employed is key to prevent the appearance of new digital trenches. Full article
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16 pages, 1618 KB  
Article
Direct Hot Solid–Liquid Extraction (DH-SLE): A High-Yield Greener Technique for Lipid Recovery from Coffee Beans
by Daliane Cláudia de Faria, Maria Eliana Lopes Ribeiro de Queiroz and Fábio Junior Moreira Novaes
Plants 2025, 14(2), 185; https://doi.org/10.3390/plants14020185 - 11 Jan 2025
Cited by 2 | Viewed by 2605
Abstract
Soxhlet extraction is a method recommended by the Association of Official Analytical Chemists (AOAC) to determine the lipid content in plant samples. Generally, n-hexane (toxicity grade 5) is used as the solvent (≈300 mL; ≈30 g sample) at boiling temperatures (69 °C) for [...] Read more.
Soxhlet extraction is a method recommended by the Association of Official Analytical Chemists (AOAC) to determine the lipid content in plant samples. Generally, n-hexane (toxicity grade 5) is used as the solvent (≈300 mL; ≈30 g sample) at boiling temperatures (69 °C) for long times (≤16 h) under a chilled water reflux (≈90 L/h), proportionally aggravated by the number of repetitions and samples determined. In this sense, the technique is neither safe nor sustainable for the analyst or the environment. This article presents the development of an alternative and more sustainable procedure for determining the lipid content in raw Arabica coffee beans. A 33 full factorial design was used to perform direct hot solid–liquid extractions in 4 mL vials, varying the ground grains and solvent ratios, temperatures, and times. An optimal condition resulted in an extractive yield statistically equivalent to Soxhlet, without variation in the composition of the oil fatty acids determined by GC-MS after hole oil transesterification. This procedure was presented as a sustainable alternative to Soxhlet extraction because it does not require water for cooling and needs a smaller volume of solvent (2 mL) and sample mass (0.2 g); it also has a smaller generated residue, as well as requiring a shorter time (1.5 h) and less energy expenditure for extraction. Full article
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18 pages, 7657 KB  
Article
Optimization and Evaluation of Cannabis-Based Magistral Formulations: A Path to Personalized Therapy
by Bożena Grimling, Magdalena Fast, Magdalena Okoniewska, Artur Owczarek and Bożena Karolewicz
Pharmaceuticals 2025, 18(1), 73; https://doi.org/10.3390/ph18010073 - 9 Jan 2025
Viewed by 4282
Abstract
Introduction: The official implementation of pharmaceutical-grade cannabis raw materials for medicinal use has permitted doctors to prescribe and pharmacists to prepare cannabis-based formulations. The objective of the pharmaceutical development and manufacturing process optimization work was to propose a suppository formulation containing doses of [...] Read more.
Introduction: The official implementation of pharmaceutical-grade cannabis raw materials for medicinal use has permitted doctors to prescribe and pharmacists to prepare cannabis-based formulations. The objective of the pharmaceutical development and manufacturing process optimization work was to propose a suppository formulation containing doses of 25 mg and 50 mg of tetra-hydrocannabinol (∆-9-THC) as an alternative to existing inhalable or orally administered formulations. The formulation could be used for rectal or vaginal administration, thereby providing dosage control in the treatment of endometriosis and other conditions involving pain. In this study, two substrates from suppositories with standardized Cannabis extractum normatum (CEX) were used: cocoa butter and Witepsol® H15. Materials and Methods: The long-term stability of CEX was investigated over a period of up to 24 months. The concentrations of ∆-9-THC, cannabidiol (CBD), and cannabinol (CBN) were determined using an HPLC method. Furthermore, the water content of the extract, the ethanol residue, and the microbiological purity were determined. The pharmaceutical properties of CEX-incorporated suppositories, namely content uniformity, hardness, softening time, total deformation time, disintegration time, and the release profile of ∆-9-THC, CBD, and CBN, were evaluated in order to develop optimal preparation procedures for pharmacists. Results and Discussion: Following a 24-month stability study on CEX, no significant alterations in component content were observed beyond the specified requirements. The disintegration time, total deformation time, and hardness of the suppositories based on Witepsol® H15 with CEX were found to be longer and higher, respectively, than those of suppositories formulated with cocoa butter. In vitro studies demonstrated that suppositories prepared with Witepsol® H15 exhibited superior release of ∆-9-THC compared to those prepared with cocoa butter. Conclusions: We suggest that pharmacists making prescription drugs in a pharmacy setting in the form of medical marijuana suppositories will receive a better release profile of the drug by choosing Witepsol® H15 as a substrate. Full article
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14 pages, 4271 KB  
Case Report
Extra-Appendiceal Neuroendocrine Expressing Goblet Cell Adenocarcinoma of the Cecum—A Case Report and Brief Review of the Literature
by Alexandra Dinu, Mariana Aşchie, Gabriela Isabela Bălţătescu, Manuela Enciu and Ionuţ Burlacu
Reports 2025, 8(1), 1; https://doi.org/10.3390/reports8010001 - 26 Dec 2024
Viewed by 1751
Abstract
Background and Clinical Significance: Neuroendocrine expressing goblet cell adenocarcinomas (GCAs) are uncommon clinically aggressive tumours of the digestive system, originating almost exclusively in the ileocecal appendix. GCA’s singularity comes from its amphicrine nature, expressing both neuroendocrine and exocrine characteristics. The case report’s [...] Read more.
Background and Clinical Significance: Neuroendocrine expressing goblet cell adenocarcinomas (GCAs) are uncommon clinically aggressive tumours of the digestive system, originating almost exclusively in the ileocecal appendix. GCA’s singularity comes from its amphicrine nature, expressing both neuroendocrine and exocrine characteristics. The case report’s objective is to raise awareness of this neoplasia’s possible extra-appendiceal localisation by showcasing a GCA involving the cecum with no detectable appendiceal tumour. Case Presentation: The authors present a case of GCA with neuroendocrine expression in an 82-year-old male patient with severe anaemia and comorbidities who underwent a right colectomy and had no histopathological evidence of appendiceal tumour involvement. Immunohistochemical testing was performed using synaptophysin, chromogranin A, neuronal specific enolase, CD56, CDX-2, CK20, CEA, MUC2 and Ki67, thus establishing the final diagnosis of high-grade extra-appendiceal goblet-cell adenocarcinoma of the cecum, G3. The patient died on postoperative day 26 due to pneumonia and acute renal failure in a chronic renal disease context. Conclusions: Extremely few cases of extra-appendiceal GCA have been reported. Appendiceal evaluation with the exclusion of this possible origin should be mandatory in such cases for a correct classification. These tumours do not benefit from any official management protocols concerning clinical evaluation, and their treatment is commonly based on the tumour’s stage, as in classical adenocarcinoma. Full article
(This article belongs to the Section Oncology)
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26 pages, 12049 KB  
Article
The Integration of ICT in the Sustainable Educational Processes of Children’s Emotional Self-Regulation: A Study Contextualised in Pandemic and Post-Pandemic Times
by Freddy Marín-González, Sandra Pachón Lozano, Michelle Sánchez Baez, Alexa Senior-Naveda, Luis Guanipa-Ramirez and Melani Pinto-Pereira
Sustainability 2024, 16(22), 10080; https://doi.org/10.3390/su162210080 - 19 Nov 2024
Cited by 2 | Viewed by 2085
Abstract
This article concerns the analysis and strengthening of children’s emotional self-regulation as a key process in the sustainable and comprehensive educational development of students from 6 to 8 years of age. The objective of the present study was to design a didactic proposal [...] Read more.
This article concerns the analysis and strengthening of children’s emotional self-regulation as a key process in the sustainable and comprehensive educational development of students from 6 to 8 years of age. The objective of the present study was to design a didactic proposal for technological mediation (WhatsApp) that contributes to emotional self-regulation and underpins the sustainable education of children in the context of the prevalence of COVID-19. The research design involved documentation, field, and propositional work. Regarding the documentation design, the content analysis technique of the Institutional Educational Project and the Coexistence Project of an official educational institution located in Bogotá, Colombia, were used. Regarding the field design, the survey technique was applied through a structured questionnaire for populations made up of second grade primary school students, parents, and teachers of the institution. Among the main results, it stands out that the prevalence of COVID-19 and its post-pandemic implications have generated greater use of available technologies, such as the WhatsApp application, evidencing a positive relationship between the level of emotional self-regulation of children and its use as a didactic mediation agent. These findings serve as input for the design of the interactive TICSR-WA proposal. Full article
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