Search Results (6,173)

Background/Objectives: Antenatal Care (ANC), delivery assisted by Skilled Birth Attendants (SBA), and Postnatal Care (PNC), collectively referred to as Continuum of Care (CoC), are platforms for delivering maternal and child nutrition interventions essential for optimal child growth. The study objective is to estimate the association between maternal utilization of CoC and childhood undernutrition in Bangladesh. Methods: Data were obtained from two nationally representative cross-sectional surveys, including Bangladesh Demographic and Health Survey (BDHS) 2017–18 and BDHS 2022. Childhood undernutrition was assessed using five indicators: (1) stunting, (2) wasting, (3) underweight, (4) any undernutrition (presence of any of first three conditions), and (5) multiple undernutrition (presence of at least two of first three conditions). Multivariable logistic regression models were used to estimate survey-specific and pooled associations. Results: Maternal utilization of full CoC was significantly associated with 51%, 35%, and 48% lower odds of childhood wasting, underweight, and multiple undernutrition in the BDHS 2022 sample, respectively. Receiving a PNC within 48 hours of delivery was significantly associated with 15% lower odds of stunting and any undernutrition in the BDHS 2017–18 sample and 17% lower odds of stunting and any undernutrition in the pooled sample. No significant differences in the survey-specific effects of maternal utilization of full CoC and its components on childhood undernutrition were observed; however, relatively stronger protective effects were evident in BDHS 2022 compared to those in BDHS 2017–18. The association between maternal utilization of full CoC and childhood stunting was not significant. Conclusions: The effectiveness of maternal utilization of CoC in preventing acute and concurrent forms of childhood undernutrition in Bangladesh has improved over time. However, substantial gap exists in translating these benefits to a reduction in chronic childhood undernutrition. Full article

Background: Menstrual-cycle-associated symptoms and menstrual health conditions are common among female athletes and may influence recovery, perceived readiness, training availability, and athletic performance. However, evidence regarding interventions aimed at managing these symptoms and their functional implications in athletes remains limited and heterogeneous. Objective: The objective of this study is to synthesize the available evidence on pharmacological and non-pharmacological interventions related to menstrual health and menstrual-cycle-associated symptoms in female athletes and to evaluate their impact on performance, recovery, functional capacity, and symptom burden. Materials and Methods: A systematic review with narrative synthesis was conducted following PRISMA 2020 guidelines. Studies evaluating interventions associated with menstrual health or menstrual-cycle-related symptoms in female athletes were included when they reported outcomes related to athletic performance, recovery, functional capacity, or symptom burden. Results: Five studies published between 2023 and 2025 were included. The interventions evaluated included hormonally related strategies involving oral contraceptive timing, recovery interventions such as cryotherapy, mindfulness-based yoga, nutritional supplementation, and pharmacological pain-modulation approaches. However, findings regarding objective athletic performance outcomes were inconsistent, and the included studies showed substantial methodological heterogeneity. Conclusions: The available evidence suggests that certain interventions related to menstrual health may contribute to improvements in symptom burden, perceived recovery, or selected functional outcomes in female athletes. Nevertheless, the current evidence base remains limited, heterogeneous, and insufficient to support strong performance-related recommendations. Further high-quality studies specifically designed in female athlete populations are needed to inform evidence-based sports medicine practice. Full article

Sarcopenia is a progressive, age-related musculoskeletal disorder characterized by the loss of skeletal muscle mass, strength, and physical performance, which contributes to frailty, disability, and mortality in older adults. Although resistance exercise and optimized protein intake remain first-line interventions, effective pharmacological therapies are limited, highlighting the need for novel adjunctive strategies. Increasing interest has focused on phytochemicals, plant-derived bioactive compounds with antioxidant, anti-inflammatory, and metabolic regulatory properties that may target multiple mechanisms underlying muscle aging. This review summarizes the molecular and translational potential of phytochemicals in sarcopenia management. Experimental and emerging clinical evidence indicates that flavonoids, polyphenols, alkaloids, and terpenoids modulate key pathways involved in sarcopenia pathogenesis, including PI3K/Akt/mTOR-mediated anabolic signaling, AMPK–SIRT3–PGC-1α-dependent mitochondrial biogenesis, NF-κB-driven inflammation, oxidative stress responses, autophagy, and satellite cell function. Through these pleiotropic effects, phytochemicals may attenuate the anabolic resistance, mitochondrial dysfunction, chronic inflammation, and impaired muscle regeneration associated with aging. Despite promising mechanistic evidence, clinical translation remains limited by poor bioavailability, variability in formulation and dosing, a lack of long-term randomized trials, and inconsistent functional outcome measures. Current evidence suggests that phytochemicals are most effective when integrated with resistance exercise and nutritional support rather than used as stand-alone therapies. Overall, phytochemicals represent promising complementary candidates for sarcopenia prevention and management. Future studies should prioritize standardized formulations, biomarker-guided approaches, and rigorously designed clinical trials focused on clinically meaningful functional outcomes to establish their efficacy, safety, and translational relevance in aging populations. Full article

Background: Obesity is increasing worldwide and remains a major contributor to cardiovascular morbidity and mortality. It is strongly associated with hypertension, dyslipidemia, diabetes mellitus, endothelial dysfunction, and chronic inflammation, all of which promote coronary artery disease and acute coronary syndrome (ACS). Despite this well-established risk profile, multiple studies have described an “obesity paradox,” suggesting that obese patients may experience better outcomes after percutaneous coronary intervention (PCI) for ACS than normal-weight individuals. Objective: This narrative review aims to discuss the pathophysiological basis of the obesity paradox and to synthesize contemporary evidence regarding the relationship between body mass index (BMI), major adverse cardiovascular events (MACE), and mortality after PCI in patients presenting with ACS. Results: Contemporary observational cohorts consistently suggest a non-linear relationship between BMI and MACE outcomes after PCI. Overweight and mildly obese patients often demonstrate lower crude mortality and fewer MACE, whereas underweight patients consistently show the poorest prognosis. However, after adjustment for age, left ventricular ejection fraction (LVEF), renal function, frailty, and nutritional status, obesity is less consistently associated with improved outcomes. Overweight status appears to be more reproducibly associated with better prognosis than obesity itself. Conclusions: The obesity paradox is likely driven less by a true protective effect of excess adiposity and more by younger age at presentation, preserved physiological reserve, lower frailty burden, and the limitations of BMI as a marker of cardiovascular risk. Underweight status emerges as the strongest predictor of adverse outcomes. Nutritional assessment and body composition should complement BMI in risk stratification after ACS. Full article

Background: Optimizing physical performance in youth football requires a comprehensive understanding of the interplay among behavioural factors, structural body composition, and functional cardiorespiratory capacity. While sports nutrition knowledge is hypothesized to influence athletic development, its concurrent relationships with regional body compartments and objective cardiopulmonary exercise testing (CPET) metrics remain poorly characterized in adolescent athletes. Methods: A cross-sectional study approach analysed body composition via bioelectrical impedance analysis (BIA), maximal cardiorespiratory testing, and sports nutrition knowledge evaluation using the Nutrition for Sport Knowledge Questionnaire (NSKQ). Structural associations and functional predictive capacities were analysed. Results: The cohort demonstrated an average VO₂max of 51.18 ± 16.67 mL/kg/min and a mean total nutrition knowledge score of 43.56 ± 18.06 out of 81 (53.8%). Total and domain-specific nutrition knowledge scores were not associated with body mass index (BMI), fat-free mass (FFM), or fat-free mass percentage (FFM%). Higher nutrition knowledge scores were independently associated with superior VO₂max and anaerobic threshold (AT) metrics. Exploratory geographic analyses revealed that rural-residing participants possessed significantly higher cardiorespiratory performance values and greater baseline nutrition knowledge profiles than their urban peers. Conclusions: In adolescent male football players, sports nutrition knowledge was not associated with static body composition measures but showed exploratory positive associations with selected cardiorespiratory fitness markers. These findings should be interpreted as cross-sectional and hypothesis-generating, as some potential confounding mediators were not assessed. These findings suggest that higher sports nutrition literacy may serve as a starting point for performance-supportive behaviours and metabolic conditioning, to some degree, warranting future interventional studies. Full article

Background/Objectives: Precision nutrition is moving beyond population-based guidance and isolated gene–diet interactions toward integrative models of dietary response. However, current approaches remain fragmented across nutrigenomics, microbiome research, multi-omics profiling, digital health, and machine learning. This review proposes the Nutri-Exposome Intelligence Framework as a conceptual, data science-driven model for integrating cumulative dietary, environmental, microbial, molecular, clinical, and digital exposures for precision chronic disease prevention. Methods: This conceptual review synthesizes the literature on precision nutrition, nutrigenetics, nutrigenomics, exposomics, gut microbiome research, multi-omics integration, wearable and biomarker-based monitoring, and machine learning in nutrition studies. Evidence was organized into a framework linking exposure assessment, host susceptibility, microbiome-mediated biotransformation, molecular response profiling, computational modelling, personalized intervention, and longitudinal feedback. Results: The proposed framework consists of seven interconnected layers: diet, environment, and lifestyle exposures; host genome and microbiome; multi-omics molecular responses; machine learning-based integration; risk prediction and responder stratification; personalized dietary intervention; and wearable and biomarker-based feedback. It positions the nutri-exposome as a cumulative exposure–response system and highlights how machine learning can support data harmonization, feature engineering, predictive modelling, responder classification, explainable interpretation, and adaptive refinement of dietary recommendations. Key applications include obesity, type 2 diabetes, cardiovascular disease, metabolic dysfunction-associated steatotic liver disease, cardiovascular–kidney–metabolic syndrome, and broader cardiometabolic prevention. Conclusions: Nutri-exposome intelligence offers a structured pathway for transforming complex nutrition data into predictive, explainable, and adaptive precision nutrition strategies. Implementation will require longitudinal and multi-ethnic cohorts, standardized metadata, causal validation, interpretable machine learning, ethical governance, and equitable access to support responsible clinical and public health translation globally. Full article

Cyanogenic glycosides in leafy vegetables pose significant food safety concerns because they release hydrogen cyanide (HCN) when plant tissue is disrupted. Although boiling is widely used for detoxification, its effects on nutritional quality and bioactive compounds remain insufficiently characterized. This study evaluated the effects of boiling on HCN, carotenoids, antioxidant capacity, and nutrient retention in Cnidoscolus aconitifolius (chaya) leaves. Antioxidant capacity was determined using the oxygen radical absorbance capacity, ferric reducing antioxidant power, and 2,2-diphenyl-1-picrylhydrazyl assays. An integrative nutrient retention index (NRI) was used to assess overall nutrient preservation. Boiling reduced HCN by 99.94%, confirming effective detoxification through hydrolysis, volatilization, and leaching. β-carotene showed high retention (95.8%), whereas thiamine (0.91%) and riboflavin (16.67%) were markedly reduced. Potassium retention was also low (24.85%). The total phenolic content and antioxidant capacity decreased significantly after boiling. The NRI indicated high retention of bioactive compounds (85.95%) but lower retention of vitamins (25.81%) and minerals (52.85%), yielding a global value of 54.92%. These findings highlight a trade-off between food safety and nutritional quality. Therefore, boiling remains a critical safety intervention for chaya and provides a useful model for optimizing processing conditions to balance detoxification with functional value. Full article

The gut microbiota (GM) has become a key mediator of host health, with dietary manipulations promising ways of modulating the microbiome. This review focuses on the role of dairy bioactive (DB) compounds as precision modulators of intestinal microecology, including the whey proteins (WPs), including lactoferrin (LF), α-lactalbumin (LA), β-lactoglobulin, lysozyme (LZ), lactoperoxidase, glycomacropeptide (GMP), milk oligosaccharides (MOs), and bioactive peptides (BPs). This review compiles the existing evidence illustrating their dual-action mechanism through direct prebiotic activity and the promotion of beneficial taxa (Bifidobacterium, Lactobacillus, Faecalibacterium), along with selective antimicrobial activity and pathogen suppression. These compounds improve intestinal barrier integrity through tight junction (TJ) protein regulation, regulating short-chain fatty acid production, and modulating immune signaling pathways. Clinical evidence shows significant benefits in metabolism and inflammation among various populations. However, individual responses vary according to host factors such as enterotypes, FUT2 genotype, and baseline microbiota composition, suggesting the need for personalized intervention strategies. This review addresses critical knowledge gaps in dose–response relationships, long-term efficacy, and mechanistic pathways and suggests future directions for precision nutrition. By modifying molecular mechanisms in clinical applications, we have identified DB compounds as promising candidates for targeted modulation of the microbiota to optimize health and disease management. The review also brings together molecular mechanistic and clinically implementable, personalized dietary strategies, which have not been fully captured by previous reviews. It pinpoints gaps in knowledge related to dose–response characterization, long-term trial design, and multi-omics stratification that collectively define a new precision nutrition framework. In this approach, dairy-based intervention is planned for each person based on their microbial, genetic, and metabolic characteristics. Full article

Fall armyworm, Spodoptera frugiperda (J.E. Smith), has emerged as one of the most damaging invasive pests affecting maize production and household food security across sub-Saharan Africa since its first detection in 2016. This systematic review synthesizes empirical evidence published between 2016 and 2025 to assess the agronomic, livelihood, and food security impacts of FAW on smallholder farming systems across Eastern, Southern, Western, and Central Africa. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and the Population, Intervention, Comparison, Outcome, Time, and Setting (PICOTS) framework, 20 studies (17 empirical and 3 contextual) were identified through comprehensive searches of academic databases and institutional repositories and were included in the final synthesis after methodological screening. The evidence indicates that FAW invasion causes substantial maize yield losses ranging from approximately 20% to 50%, with the greatest reductions reported in rain-fed systems with limited access to pest management technologies. Infestation rates frequently exceeded 50%, particularly during early invasion phases. Beyond agronomic losses, several studies reported reduced household income, constrained food availability, and livelihood disruptions, including increased labor requirements, higher production costs, and reliance on short-term coping strategies. Only a small proportion of studies (n = 4) directly assessed nutrition-related indicators, but the available evidence indicates declines in dietary diversity in severely affected communities. Overall, the agronomic impacts of FAW are consistently documented across regions, whereas the socioeconomic and nutrition outcomes remain comparatively underreported, indicating a significant evidence gap. These findings highlight FAW as both an agronomic and livelihood challenge, underscoring the need for integrated pest management strategies, strengthened extension services, and coordinated policy responses to safeguard food and income security among smallholder farmers in Africa. Full article

Colitis is a global health challenge that severely impairs quality of life, necessitating effective dietary interventions. This study investigated the protective effects of Ganoderma lucidum triterpenoids (GLTs) on pathological symptoms, inflammatory responses, and gut microbiota dysbiosis in a dextran sulfate sodium (DSS)-induced murine model. Our results demonstrated that GLT intervention significantly attenuated the disease activity index (DAI), prevented colon shortening, and fortified gut barrier integrity through upregulating the transcription of tight junction proteins. GLT inhibited the secretion of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) and bolstered antioxidant defenses (CAT) by controlling the TLR4/NF-κB pathway and upregulating the Nrf2 pathway. Furthermore, 16S rRNA sequencing and non-targeted metabolomics revealed that GLT reshaped the gut microbial landscape (enriching Enterorhabdus and Lachnospiraceae NK4A136 group) and reconfigured amino acid metabolism to restore colonic homeostasis. Collectively, these findings highlight the potential of GLT as a functional food ingredient to prevent colitis, potentially linked to the modulation of the microbiota–metabolite–immune interplay, offering a novel nutritional strategy for inflammatory bowel disease management. Full article

Background/Objectives: Ventricular septal defect (VSD) is the most common congenital heart disease in children and is often associated with growth impairment and malnutrition. Increased metabolic demand, feeding difficulties, and recurrent infections contribute to poor nutritional status. Insulin-like growth factor-1 (IGF-1), a key mediator of growth hormone activity, reflects nutritional and metabolic conditions. Previous studies have evaluated endocrine and growth abnormalities in heterogeneous congenital heart disease populations. However, data specifically examining the relationship between serum IGF-1 levels and nutritional status in isolated pediatric ventricular septal defect remain limited, particularly in Southeast Asian populations. Methods: The single centre observational case–control study was conducted at Dr. Soetomo Hospital, Surabaya, involving 110 children (55 VSD patients and 55 healthy controls). VSD diagnosis was confirmed by echocardiography. Nutritional status was assessed using WHO anthropometric criteria. Serum IGF-1 levels were measured using ELISA. Statistical analyses compared IGF-1 levels between groups and across nutritional categories. Results: Moderate and severe wasting were more common in the VSD group. Median IGF-1 levels were significantly lower in VSD patients compared to controls (5.18 vs. 21.4 ng/mL; p < 0.001). A positive association between IGF-1 levels and nutritional status was observed. Conclusions: Children with VSD have poorer nutritional status and significantly lower IGF-1 levels compared to healthy controls. This association may be explained by the dysregulation of the growth hormone–IGF-1 axis. IGF-1 may complement nutritional assessment for identifying and monitoring growth impairment and guiding early nutritional interventions in pediatric VSD. Full article

This paper describes the development and design of Nutrition for Athletes: A Focus on Dietary Supplements, an online educational intervention created for varsity athletes at the University of Guelph. Guided by the Theory of Planned Behaviour (TPB), the program aimed to improve athletes’ nutrition and dietary supplement-related knowledge while modifying attitudes, subjective norms, perceived behavioral control, intentions, and behaviors associated with dietary supplement use. Formative research with the target population revealed widespread misconceptions, strong social influences, and high perceived benefits of supplement use, which highlighted the need for an intervention focused on reshaping underlying beliefs. The program covered topics related to sports nutrition, hydration, dietary supplements, and risks of supplement use, and was integrated into the university’s learning management system. Each unit was mapped onto relevant TPB constructs, with an emphasis on correcting inaccurate beliefs and promoting a food-first approach. The program’s effectiveness was evaluated through pre- and post-intervention questionnaires assessing knowledge and TPB constructs. This paper outlines the theoretical framework, development process, and content structure of the intervention, and presents a model that can be replicated in future educational programs. Full article

Background/Objectives: Phenylketonuria (PKU) is a rare autosomal recessive disorder caused by phenylalanine hydroxylase (PAH) deficiency, impairing the conversion of phenylalanine (Phe) to tyrosine. Although early diagnosis and intervention yield excellent outcomes, dietary adherence often declines in adulthood, potentially leading to poor metabolic control and adverse nutritional consequences. This study aimed to evaluate physical activity levels, nutritional status, metabolic control, and anthropometric outcomes in adults with classic PKU, which have not been sufficiently researched in the current literature. Methods: This cross-sectional study included 100 adults with classical PKU (cPKU; baseline phenylalanine levels ≥ 1200 µmol/L) under regular follow-up at the Division of Metabolism, Hacettepe İhsan Doğramacı Childrens’ Hospital. Sociodemographic traits and dietary behaviors were evaluated through structured interviews carried out by a dietitian. Dietary intake was assessed by using a 24 h dietary recall method, and nutrient analyses were performed with the Bebis 7.2 software program. Using the short version of the International Physical Activity Questionnaire (IPAQ), physical activity levels were specified, and participants were categorized according to established scoring criteria. Results: A hundred adults with classical PKU took part in the study, including 47 males and 53 females, with a mean age of 23.84 ± 5.41 years; 5% of participants were underweight, 40% had normal weight, 39% were overweight, and 16% were listed as obese. The intake of mean daily energy is 2443.8 ± 384.6 kcal for men and 1822.5 ± 312.7 kcal for women. Carbohydrates contributed approximately 61% of total daily energy intake in both genders, whereas protein accounted for 12–13% and fat for approximately 26–27% of total energy intake; 17% of participants were physically inactive, 40% were minimally active, and 43% met criteria for sufficient physical activity according to IPAQ-based classification. Energy intake, the use of Phe-free protein substitutes, and BMI were significantly higher in the sufficiently active group compared to the low-active group in men, while no significant differences were observed between physical activity groups among women. Conclusions: Adults with classical PKU showed a high prevalence of overweight and obesity, together with differences in dietary intake and physical activity patterns. Physical activity levels were associated with several nutritional and metabolic characteristics; however, further long-term research is required to fully understand these connections. Full article

Reproductive performance is closely linked to nutrient availability, yet the specific nutrient-derived cues governing oviposition decision-making remain inadequately defined. Chemically defined holidic media used in Drosophila melanogaster studies provide precise control over dietary components; however, the mechanisms by which individual nutrients exert acute effects on inter-organ endocrine signaling to trigger oviposition behavior are not well understood. In a two-choice oviposition assay, where substrates are presented within the same chamber, we observed that HM induces a rapid increase in egg laying in D. melanogaster compared to grape/apple juice media (GJM), yielding 4.02× and 5.27× more eggs at 2 h and 8 h, respectively. Systematic nutrient omission and subsequent supplementation identify lysine as the key essential amino acid driving this rapid oviposition response. Notably, this phenomenon reflects a short-term oviposition reaction, rather than long-term nutritional modulation of ovarian development. Lysine supplementation results in elevated levels of 20-hydroxyecdysone (20E) and juvenile hormone (JH), as well as the induction of ecdysis-triggering hormone (ETH) expression. Pharmacological interventions support a model in which a 20E–ETH–JH endocrine cascade underlies the lysine-dependent phenotype: methoprene phenocopies the effect, whereas precocene suppresses the HM-induced increase in egg laying. A 20E analog similarly enhances oviposition. Consistent with the role of JH in reproductive tissues, activation of the JH pathway correlates with increased expression of extracellular matrix genes in the ovarian muscle. Collectively, these results demonstrate that lysine acts as a critical nutritional cue to activate the 20E–ETH–JH endocrine axis and acutely promote egg laying behavior in D. melanogaster over a short time period. This provides a defined framework for investigating the short-term nutrient hormone regulation of ovulation and offers a practical strategy for efficient egg collection. Full article

Background and Aim: The gluten-free diet (GFD) can have a huge impact on the quality of life of people with celiac disease (CD), especially on a social level. The objective of this work is to evaluate a structured nutrition education program focused on CD and GFD that aims to increase knowledge and improve inclusion attitudes about the disease in children. Methods: This is a one-month intervention for school children aged 10–12 years called Zeliakide (8 sessions). It was carried out through a STEAM methodology, using inquiry-based learning. The participants responses were evaluated through questionnaires before and after the intervention, and participants were also followed up one month later. The control group was a similar group of students who followed their regular school curriculum. Results: 299 children from one school of Vitoria-Gasteiz took part in the study (155 intervention group; 144 control group). Zeliakide significantly improved knowledge about CD and GFD in children, and this knowledge was retained for one month. Concretely, students increased their ability to explain what CD is, to assess gluten, and to classify food groups according to gluten content. The intervention contributed to augmenting the selection of behaviors to overcome differences between individuals, assessed one month after the intervention. In addition, the program allowed students to understand the work of scientists. Conclusions: Zeliakide can contribute to nutrition education initiatives that aim to improve knowledge of CD and GFD in the general population, while promoting empathetic behavior towards people with CD. Registration: clinicaltrials.gov, NCT05467865 on 21 July 2022. Full article