Search Results (4,362)

This study examined the distribution and disease associations of non-HLA-B*27 HLA-B alleles in Romanian spondyloarthritis (SpA) patients, aiming to address the underrepresentation of Eastern European populations in immunogenetic research. Methods: We analyzed 263 HLA-B*27-negative patients from Northeastern Romania fulfilling ASAS criteria. HLA-B genotyping was performed at two-digit resolution, and allele distributions were compared with two Romanian HLA-B*27-negative control groups (n = 335 and n = 1705 cases), using chi-square testing and logistic regression. Compared to controls, HLA-B*47 (p = 0.0007) and HLA-B*54 (p = 0.0013) were significantly enriched, while HLA-B*40 was underrepresented (p = 0.0287). Notably, HLA-B*54 was observed exclusively in axial SpA. Within the cohort, both HLA-B*13 and HLA-B*57 alleles were associated with psoriasis, while HLA-B*37 and HLA-B*41 alleles were clustered within the reactive arthritis group. The HLA-B*35 and HLA-B*18 alleles were the most frequently observed alleles across most clinical phenotypes. When comparing the frequency of HLA-B associations, the most common genotypes among SpA patients were B*08-B*18, B*13-B*35, and B*35-B*51. Notably, B*08-B*18 was more frequent in patients with radiographic sacroiliitis grade ≥ 2, while B*35-B*51 was more frequent in those with confirmed systemic inflammation, as indicated by elevated CRP or ESR levels. Analysis of peptide-binding patterns revealed a cluster of risk alleles, HLA-B*08, B*18, B*35, B*40, and B*54, sharing similar features, distinct from the canonical profile of B*27. These findings highlight the contribution of non-B*27 HLA-B alleles to SpA susceptibility in an Eastern European population and support the notion that HLA-B*27-negative SpA may represent a distinct clinical and immunological entity, driven by alternative pathogenic mechanisms. They also emphasize the importance of population-specific immunogenetic profiling and support expanding genetic characterization in HLA-B*27-negative patients. Full article

Urban sustainability challenges demand integrated frameworks capable of addressing the dynamic, non-linear nature of cities. This study explores how the principles of the circular economy and complexity theory intersect to support systemic transformation in sustainable urban planning. Through a systematic literature review of 71 peer-reviewed articles published between 2015 and 2025, we analyze conceptual, methodological, and practical articulations across multiple thematic axes, including circular governance, urban metabolism, regenerative design, adaptive planning, digital integration, and environmental justice. Bibliometric and content analyses were conducted using Scopus metadata, VOSviewer for thematic clustering, and the StArt software (Version 3.4) to structure article selection. The findings reveal that circular economy provides practical tools for resource efficiency and regeneration, while complexity theory offers an adaptive framework to navigate uncertainty, emergent behaviors, and feedback dynamics. The synthesis suggests that their integration enables a more holistic and resilient approach to urban transformation. However, gaps remain in social inclusivity, long-term assessment, and the operationalization of complexity-informed planning. This study contributes to advancing a transdisciplinary agenda for circular and adaptive urban futures, offering insights for scholars, planners, and policymakers aiming to reconfigure cities within planetary boundaries. Full article

For the first time, comprehensive investigations into the tensile load-bearing behavior and crack formation of reinforced concrete based on ultrasound are presented. Uniaxial tensile tests are performed on reinforced concrete tension members equipped with embedded ultrasonic transducers. Key mechanical parameters across all ranges of tensile behavior are continuously quantified by recording ultrasonic signals and evaluated with coda wave interferometry. The investigations include member configurations of different lengths to cover different numbers of cracks. For reference, crack patterns and crack widths are analyzed using digital image correlation, while the strain in the reinforcement is monitored with distributed fiber optic sensors. For the first time, a direct proportional relationship between the relative velocity change in ultrasonic signals and crack widths is established in the ranges of crack formation and stabilized cracking. In the non-cracked state, linear correlations are found between the velocity change and the average strain, as well as the length of the specimens. The experimental results significantly enhance the general understanding of the phenomena related to ultrasonic signals in flexural reinforced concrete members, particularly concerning cracking in the tensile zone. Consequently, this study contributes to the broader objective of employing coda wave interferometry to evaluate the condition of infrastructure. Full article

Background: Social and financial services are essential for the inclusion and well-being of people with disabilities (PWDs), who often rely on family caregivers to access these systems. In Saudi Arabia, where disability inclusion is a strategic goal under Vision 2030, understanding caregiver experiences is crucial to identifying service gaps and improving accessibility. Objectives: This study aimed to explore caregivers’ perspectives on awareness, perceived barriers, and accessibility of social and financial services for PWDs in Saudi Arabia. The analysis is grounded in Andersen’s Behavioural Model of Health Service Use and the WHO’s International Classification of Functioning, Disability and Health (ICF) framework. Methods: A cross-sectional survey was conducted with 3353 caregivers of PWDs attending specialised day schools. The survey collected data on demographic characteristics, service awareness, utilisation, and perceived obstacles. Exploratory Factor Analysis (EFA) identified latent constructs, and Structural Equation Modelling (SEM) was used to test relationships between awareness, barriers, and accessibility. Results: Findings reveal that over 70% of caregivers lacked awareness of available services, and only about 3% had accessed them. Key challenges included technological barriers, complex procedures, and non-functional or unclear service provider platforms. Both User Barriers and Service Barriers were negatively associated with Awareness and Accessibility. Awareness, in turn, significantly predicted perceived Accessibility. Caregiver demographics, such as age, education, gender, and geographic location, also influenced awareness and service use. Conclusions: There is a pressing need for targeted awareness campaigns, accessible digital service platforms, and simplified service processes tailored to diverse caregiver profiles. Inclusive communication, decentralised outreach, and policy reforms are necessary to enhance service access and promote the societal inclusion of PWDs in alignment with Saudi Arabia’s Vision 2030. Full article

Land use conversion to perennial cropland often degrades the soil structure and fertility, particularly under Mediterranean climatic conditions. This study assessed spatial and temporal dynamics of soil properties and tree responses to 3-year repeated mature compost additions in a citrus orchard. Digital soil mapping revealed strong baseline heterogeneity in texture, CEC, and Si pools. Compost application markedly increased total organic C and N levels, aggregate stability, and pH with noticeable changes after the first amendment, whereas a limited C storage potential was found following further additions. NDVI values of tree canopies monitored over a 3-year period showed significant time-dependent changes not correlated with the soil fertility variables, thus suggesting that multiple interrelated factors affect plant responses. The non-crystalline amorphous Si/total amorphous Si (_iSi:Si_amor) ratio is here proposed as a novel indicator of pedogenic alteration in disturbed agroecosystems. These findings highlight the importance of tailoring organic farming strategies to site-specific conditions and reinforce the value to combine C and Si pool analysis for long-term soil fertility assessment. Full article

As ad-supported subscription models proliferate across over-the-top (OTT) media platforms, understanding the psychological mechanisms and perceptual factors that underlie consumers’ transition decisions becomes increasingly consequential. This study integrates the Uses and Gratifications framework with a contemporary motivation-based perspective to examine how users’ media consumption motivations and advertising attitudes predict intentions to adopt ad-supported OTT plans. Data were collected via a nationally representative online survey in South Korea (N = 813). The sample included both premium subscribers (n = 708) and non-subscribers (n = 105). The findings reveal distinct segmentation in decision-making patterns. Among premium subscribers, switching intentions were predominantly driven by intrinsic motivations—particularly identity alignment with content—and by the perceived informational value of advertisements. These individuals are more likely to consider ad-supported plans when ad content is personally relevant and cognitively enriching. Conversely, non-subscribers exhibited greater sensitivity to extrinsic cues such as the entertainment value of ads and the presence of tangible incentives (e.g., discounts), suggesting a hedonic-reward orientation. By advancing a dual-pathway explanatory model, this study contributes to the theoretical discourse on digital subscription behavior and offers actionable insights for OTT service providers. The results underscore the necessity of segment-specific advertising strategies: premium subscribers may be engaged through informative and identity-consistent advertising, while non-subscribers respond more favorably to enjoyable and benefit-laden ad experiences. These insights inform platform monetization efforts amid the evolving dynamics of consumer attention and subscription fatigue. Full article

This study examines how Environmental, Social, and Governance (ESG) reporting is communicated and perceived on YouTube. A dataset of 553 relevant videos and 5060 user comments was extracted on 2 April 2025 ranging between 2014 and 2025, and sentiment, topic, and stance analyses were applied to both transcripts and comments. The majority of video content strongly endorsed ESG reporting, emphasizing themes such as transparency, regulatory compliance, and financial performance. In contrast, viewer comments revealed diverse stances, including skepticism about methodological inconsistencies, accusations of greenwashing, and concerns over politicization. Notably, statistical analysis showed minimal correlation between video sentiment and audience sentiment, suggesting that user perceptions are shaped by factors beyond the tone of the videos themselves. These findings underscore the need for more rigorous ESG frameworks, enhanced standardization, and proactive stakeholder engagement strategies. The study highlights the value of online platforms for capturing stakeholder feedback in real time, offering practical insights for organizations and policymakers seeking to strengthen ESG disclosure and communication. Full article

Objective: To evaluate the concordance of automated 3D superimposition methods applied to digital models, with a focus on methods that consider stable palatal regions as geometric reference landmarks versus those that do not. Design and setting: This was a prospective, cross-sectional study using digital model files of patients undergoing orthodontic treatment in a university clinical setting. Participants: Sixty-one patients were prospectively enrolled and divided into three groups based on the type of orthodontic treatment they received: (20) non-extractive orthodontic treatment without intermaxillary elastics, (21) intermaxillary elastics, and (20) control subjects with no orthodontic movement. The inclusion criteria included the availability of complete pre- and post-treatment digital casts and the absence of significant craniofacial anomalies. Methods: Three superimposition methods were tested: (1) superimposition according to palate and palatal ridges, (2) best-fit superimposition of arches in occlusion, and (3) best-fit superimposition of individual arches. Discrepancies were identified by comparing the spatial positions derived from each method. Within three spatial axes, deviations of ±0.5 mm and ±1.15° were not considered significant. Bland–Altman plots were used to quantify palatal rugae based and non-based spatial differences between methods. Differences in the superimposition results between the three patient groups were evaluated using ANOVA tests. Results: Differences in spatial position between the superimposition methods often exceeded the acceptable range. The results were compared between the three patient groups with a statistical significance of α = 0.05. In the present study, the high reliability of the superimposition method based on the palate and palatal ridges was observed. Conclusion: Superimposition methods based on the palate and palatal rugae provide superior accuracy in determining treatment-related changes in upper arch digital models. These findings illustrate the need for appropriate selection of superimposition techniques based on the study objective of using clinically relevant techniques. Full article

According to the United Nations Environment Programme reports, buildings are responsible for nearly 40% of energy-related emissions; therefore, energy-optimized building design is crucial to reduce the reliance on non-renewable energy sources as well as greenhouse gas emissions. The OECD reports indicate the use of Building Information Modelling (BIM) as one of the effective strategies for decarbonization of buildings, since a 3D digital representation of both physical and functional characteristics of a building can help to design a more efficient infrastructure. An efficient integration of solar energy in building design can be vital for the enhancement of energy performance in terms of heating, cooling, and lighting demand. This paper presents results of an analysis of how factors related to the use of daylight, such as automatic control of artificial lighting, external shading, or the visual absorptance of internal surfaces, influence the energy efficiency within an example room in two different climatic zones. The simulation was conducted using Design Builder software, with predefined occupancy schedules and internal heat gains, and standard EPW weather files for Warsaw and Genua climate zones. The study indicates that for the examined room, when no automatic sunshades or a lighting control system is utilized, most of the final energy demand is for cooling purposes (45–54%), followed by lighting (42–43%), with only 3–12% for heating purposes. The introduction of sunshades and/or the use of daylight allowed for a reduction of the total demand by up to half. Moreover, it was pointed out that often neglected factors, like the colour of the internal surfaces, can have a significant effect on the final energy consumption. In variants with light interior, the total energy consumption was lower by about 3–4% of the baseline demand, compared to their corresponding ones with dark surfaces. These results are consistent with previous studies on daylighting strategies and highlight the importance of considering both visual and thermal impacts when evaluating energy performance. Similarly, possible side effects of certain actions were highlighted, such as an increase in heat demand resulting from a reduced need for artificial lighting. The results of the analysis highlight the potential of a simulation-based design approach in optimizing daylight use, contributing to the broader goals of building decarbonization. Full article

Museums play an essential role in preserving both cultural and natural heritage, safeguarding samples that offer invaluable insights into our history and scientific understanding. The integration of micro-computed tomography (micro-CT) has significantly advanced the study, restoration, and conservation of these priceless objects. This work explores the application of micro-CT across three critical areas of museum practice: sample virtualization, restoration assessment, and the analysis of fossil specimens. Specifically, micro-CT scanning was applied to fossils stored in the G.A.M.P.S. collection (Scandicci, Italy), enabling the creation of highly detailed non-invasive 3D models for digital archiving and virtual exhibitions. At the Opificio delle Pietre Dure in Florence, micro-CT was employed to evaluate fossil bone restoration treatments, focusing on the internal impact of menthol as a consolidant and its effects on the structural integrity of the material. Furthermore, micro-CT was utilized to investigate a sealed bee preserved in its cocoon within a paleosol in Costa Vicentina (Portugal), providing unprecedented insights into its internal anatomy and state of preservation, all while maintaining the integrity of the specimen. The results of this study underscore the versatility of micro-CT as a powerful non-destructive tool for advancing the fields of conservation, restoration, and scientific analysis of cultural and natural heritage. By integrating high-resolution imaging with both virtual and hands-on conservation strategies, micro-CT empowers museums to enhance research capabilities, improve preservation methodologies, and foster greater public engagement with their collections. Full article

Integrating artificial intelligence (AI) and cause-related marketing has reshaped corporate social responsibility practices while triggering a conflict between technological instrumental rationality and moral value transmission. Building on the Persuasion Knowledge Model (PKM) and AI aversion literature, this research employs two experiments to reveal that AI disclosure exerts a unique inhibitory effect on consumers’ purchase intentions in cause-related marketing contexts compared to non-cause-related marketing scenarios. Further analysis uncovers a chain mediation pathway through consumer skepticism and advertisement attitudes, explaining the psychological mechanism underlying AI disclosure’s impact on purchase intentions. The study also identifies the moderating role of AI aversion within this chain model. The findings provide a new theoretical perspective for integrating AI disclosure, consumer psychological responses, and marketing effectiveness while exposing the “value-instrumentality” conflict inherent in AI applications for cause-related marketing. This research advances the evolution of the PKM in the digital era and offers practical insights for cause-related marketing enterprises to balance AI technology application with optimized disclosure strategies. Full article

In recent years, research on plant disease detection has combined artificial intelligence, hyperspectral imaging, unmanned aerial vehicle remote sensing, and other technologies, promoting the transformation of pest and disease control in smart agriculture towards digitalization and artificial intelligence. This review systematically elaborates on the research status of non-destructive detection techniques used for plant disease identification and detection, mainly introducing the following two types of methods: spectral technology and imaging technology. It also elaborates, in detail, on the principles and application examples of each technology and summarizes the advantages and disadvantages of these technologies. This review clearly indicates that non-destructive detection techniques can achieve plant disease and pest detection quickly, accurately, and without damage. In the future, integrating multiple non-destructive detection technologies, developing portable detection devices, and combining more efficient data processing methods will become the core development directions of this field. Full article

This paper presents a novel digital identity ecosystem built upon a hierarchical structure of Blockchain tokens, where both government-certified and uncertified tokens can coexist to represent various attributes of an individual’s identity. At the core of this system is the government, which functions as a trusted authority capable of creating entities and issuing a unique, non-replicable digital identity token for each one. Entities are the exclusive owners of their identity tokens and can attach additional tokens—such as those issued by the government, educational institutions, or financial entities—to form a verifiable, token-based digital identity tree. This model accommodates a flexible identity framework that enables decentralized yet accountable identity construction. Our contributions include the design of a digital identity system (supported by smart contracts) that enforces uniqueness through state-issued identity tokens while supporting user-driven identity formation. The model differentiates between user types and certifies tokens according to their source, enabling a scalable and extensible structure. We also analyze the economic, technical, and social feasibility of deploying this system, including a breakdown of transaction costs for key stakeholders such as governments, end-users, and institutions like universities. Considering the benefits of blockchain, implementing a digital identity ecosystem in this technology is economically viable for all involved stakeholders. Full article

Background/Objectives: Oral cancer resection often leads to maxillofacial defects and dentition loss, compromising patients’ quality of life. Implant-supported prosthetic rehabilitation offers a reliable solution to restore function, though factors such as bone reconstruction, radiotherapy, and timing of implant placement (immediate vs. delayed) may influence outcomes. This study aimed to evaluate long-term implant survival and rehabilitation timelines in oncologic patients, comparing two cohorts (2005–2014 and 2015–2024) to assess the impact of evolving clinical practices. Methods: A retrospective cohort study was conducted at Hospital General Universitario Gregorio Marañón (Madrid, Spain), including 304 patients who underwent ablative oral cancer surgery and subsequent implant-based rehabilitation between 2005 and 2024. Data on demographics, oncologic treatment, reconstruction, implant timing, and prosthetic rehabilitation were collected. Outcomes were compared using Kaplan–Meier analysis and appropriate statistical tests between the 2005–2014 (n = 122) and 2015–2024 (n = 182) cohorts. Results: A total of 2341 Ticare Implants^® were placed, supporting 281 prostheses. Implant placement during primary surgery increased from 41% to 71% (p < 0.001). The median time from surgery to prosthesis significantly decreased from 24 to 15 months (p < 0.001). Five-year implant survival was 95% in the early cohort versus 97% in the later cohort. Implant survival was comparable between irradiated and non-irradiated patients (~94–96%). Fixed prostheses became more frequent (92% vs. 79%, p = 0.002). Conclusions: Implant-supported rehabilitation in oncologic patients is highly feasible and durable, with improved timelines and functional outcomes associated with early implant placement and modern digital planning strategies. Full article

The introduction of mobile banking is essential in today’s financial sector, where technological innovation plays a critical role. To remain competitive in the current market, businesses must analyze client attitudes and perspectives, as these influence long-term demand and overall profitability. While previous studies have explored general adoption behaviors, limited research has examined how individual factors such as social influence, lifestyle compatibility, financial technology self-efficacy, and perceived usage cost affect mobile banking adoption among specific generational cohorts. This study addresses that gap by offering insights into these variables, contributing to the growing literature on mobile banking adoption, and presenting actionable recommendations for financial institutions targeting younger market segments. Using a structured questionnaire survey, data were collected from both users and non-users of mobile banking among the Gen Z population in the United States. The regression model significantly predicts mobile banking adoption, with an intercept of $-0.548$ ($p < 0.001$). Among the independent variables, perceived cost of usage has the strongest positive effect on adoption ($B=0.857$, $\beta =0.722$, $p < 0.001$), suggesting that adoption increases when mobile banking is perceived as more affordable. Social influence also has a significant positive impact ($B=0.642$, $\beta =0.643$, $p < 0.001$), indicating that peer influence is a central driver of adoption decisions. However, self-efficacy shows a significant negative relationship ($B=-0.343$, $\beta =-0.339$, $p < 0.001$), and lifestyle compatibility was found to be statistically insignificant ($p=0.615$). These findings suggest that reducing perceived costs, through lower fees, data bundling, or clearer communication about affordability, can directly enhance adoption among Gen Z consumers. Furthermore, leveraging peer influence via referral rewards, Partnerships with influencers, and in-app social features can increase user adoption. Since digital self-efficacy presents a barrier for some, banks should prioritize simplifying user interfaces and offering guided assistance, such as tutorials or chat-based support. Future research may employ longitudinal designs or analyze real-life transaction data for a more objective understanding of behavior. Additional variables like trust, perceived risk, and regulatory policies, not included in this study, should be integrated into future models to offer a more comprehensive analysis. Full article