Search Results (8,668)

2-acetylfuran is a product of the Maillard reaction and is widely found, especially in heat-processed foods such as grain products, baked goods, and dairy products. Although 2-acetylfuran contributes to flavor, high concentrations may be toxic. Its target organs and dose–response relationships remain poorly characterized. In this study, transgenic zebrafish with fluorescently labeled immune and neural systems were used to assess the effects of 2-acetylfuran on immune and neural development. Wild-type zebrafish were employed to assess the toxicity of 2-acetylfuran on locomotor ability, gastrointestinal development, and liver function. The maximum non-lethal concentration (MNLC) and the 10% lethal concentration (LC₁₀) for zebrafish embryos were 0.844 and 0.889 μL/mL, respectively. Regarding immunotoxicity, at concentrations of 0.281, 0.844, and 0.889 μL/mL, 2-acetylfuran significantly reduced the numbers of neutrophils, T cells, and macrophages. Regarding locomotor and neurotoxicity, motor speed and total locomotor distance were significantly reduced at 0.844 and 0.889 μL/mL. These findings were consistent with neurodevelopmental assessments, in which 0.844 μL/mL 2-acetylfuran resulted in a significant increase in apoptotic cells in the central nervous system and markedly shortened peripheral motor nerve lengths. Regarding gastrointestinal toxicity, 0.844 and 0.889 μL/mL 2-acetylfuran significantly reduced the gastrointestinal area, while neutrophil counts showed no significant changes, suggesting a relatively mild effect on the gastrointestinal tract. Regarding hepatic toxicity, all tested concentrations of 2-acetylfuran primarily increased the delayed yolk sac absorption area. Furthermore, at 0.844 μL/mL, histological examination revealed hepatic pathological changes characterized by hepatocyte nuclear swelling, vacuolar degeneration, and hepatocyte necrosis. In summary, this study reveals the multi-organ toxicity profile of 2-acetylfuran in the zebrafish model, with particularly high sensitivity in the immune system and liver. This research provides theoretical support for risk assessment and process control of 2-acetylfuran in foods. Full article

Ophiocordyceps sinensis is a precious medicinal material with significant pharmacological and economic value. However, the visual similarity between its wild and cultivated forms poses a challenge for authentication. This study investigates the influence of specimen orientation on the accuracy of hyperspectral identification. Hyperspectral data were systematically acquired from four standard specimen orientations (left lateral, right lateral, dorsal, and ventral) for each sample. Random Forest (RF), Support Vector Machine (SVM), Logistic Regression (LR), and Fully Connected Neural Network (FCNN) models were trained and evaluated using both single-orientation and multi-orientation fused data. Results indicate that the LR model achieved superior and stable performance, with an average identification accuracy exceeding 98%. Crucially, for all tested models, no statistically significant difference in identification accuracy was observed across the different specimen orientations. This finding demonstrates that specimen orientation does not significantly influence identification accuracy. The conclusion was further corroborated in experiments using randomly orientation-fused datasets, in which model performance remained consistent and reliable. It is therefore concluded that precise specimen orientation control is unnecessary for the hyperspectral identification of Ophiocordyceps sinensis. This insight substantially simplifies the hardware design of dedicated identification devices by eliminating the need for complex orientation-fixing mechanisms and facilitating the standardization of operational protocols. The study provides a practical theoretical foundation for developing cost-effective, user-friendly, and widely applicable identification instruments for Ophiocordyceps sinensis and offers a reference for similar non-destructive testing applications involving anisotropic medicinal materials. Full article

Machine learning (ML)-powered vision for robotic inspection has accelerated with smart manufacturing, enabling automated defect detection and classification and real-time process optimization. This review provides insight into the current landscape and state-of-the-art practices in smart manufacturing quality control (QC). More than 50 studies spanning across automotive, aerospace, assembly, and general manufacturing sectors demonstrate that ML-powered vision is technically viable for robotic inspection in manufacturing. The accuracy of defect detection and classification frequently exceeds 95%, with some vision systems achieving 98–100% accuracy in controlled environments. The vision systems use predominantly self-designed convolutional neural network (CNN) architectures, YOLO variants, or traditional ML vision models. However, 77% of implementations remain at the prototype or pilot scale, revealing systematic deployment barriers. A discussion is provided to address the specifics of the vision systems and the challenges that these technologies continue to face. Finally, recommendations for future directions in ML-powered vision for robotic inspection in manufacturing are provided. Full article

The use of robots in various industries has increased significantly in recent years, with mobile robots playing a central role in automation. Their applications range from service robotics and automated material handling to bomb disposal and planetary exploration. A rapidly growing area of mobile robotics involves coordinated groups of autonomous robots, commonly referred to as swarms. However, only a limited number of studies have addressed systems in which ropes or wires physically connect robots. Connecting multiple autonomous robotic vehicles with a tensioned wire can form a movable fence, enabling coordinated motion as a single dynamic entity. This paper presents a real-time control approach for the off-road motion of physically connected skid-steering robotic vehicles. A numerical-simulation-driven artificial neural network is employed as a surrogate model to estimate wheel–ground load distribution online, enabling stable steering control and accurate trajectory tracking on rough terrain while accounting for wire-induced coupling effects. Full article

Background: Perceptual decision-making requires transforming sensory inputs into goal-directed actions under uncertainty. Neural oscillations in the theta band (3–7 Hz), particularly within frontal regions, have been implicated in cognitive control and decision confidence. However, whether changes in theta oscillations reflect greater effort during ambiguous decisions or more efficient control during clear conditions remains debated, and theta’s relationship to stimulus clarity is incompletely understood. Purpose: This study’s purpose was to examine how task difficulty modulates theta activity and how theta dynamics evolve across the decision-making process using two complementary analytical approaches. Methods: Electroencephalography (EEG) data were acquired from 26 healthy adults performing a face/house categorization task with images containing three levels of scrambled phase and Gaussian noise: clear (0%), moderate (40%), and high (55%). Theta dynamics were assessed from current source density (CSD) time courses of event-related potentials (ERPs) and single-trials. Statistical comparisons used Wilcoxon signed-rank tests with false discovery rate (FDR) correction for multiple comparisons. Results: Frontal theta power was greater for clear than noisy face stimuli (corrected p < 0.001), suggesting that theta activity reflects cognitive control effectiveness and decision confidence rather than processing difficulty. Connectivity decomposition revealed that frontoparietal theta coupling was modulated by stimulus clarity through both phase-locked (evoked: corrected p = 0.0085, dz = −0.61) and ongoing (induced: corrected p = 0.049, dz = −0.36) synchronization, with phase-locked coordination dominating the effect and showing opposite directionality to the induced components. Conclusions: Theta oscillations support perceptual decision-making through stimulus clarity modulation of both phase-locked and ongoing synchronization, with evoked component dominating. These findings underscore the importance of methodological choices in EEG-based connectivity research, as different analytical approaches capture different aspects of the same neural dynamics. The pattern of stronger theta activity for clear stimuli is consistent with neural processes related to decision confidence, though confidence was not measured behaviorally. Full article

An adaptive control strategy is developed and analyzed for trajectory tracking of mechanical systems subject to simultaneous model uncertainties and full-state constraints. To overcome the significant hurdle of guaranteeing both transient and steady-state performance within a user-defined time, a novel predefined-time adaptive neural network (NN) control scheme is proposed. By integrating predefined-time stability theory with a nonlinear mapping framework, a control scheme is developed to rigorously enforce full-state constraints while achieving predefined-time convergence. Radial basis function neural networks (RBFNNs) are employed to approximate the unknown system dynamics, with adaptive laws designed for online learning. The nonlinear mapping is strategically incorporated to ensure that the full-state constraints are never violated throughout the entire operation. Furthermore, through Lyapunov stability theory, it is proved that all signals of the resulting closed-loop system are uniformly ultimately bounded, and most importantly, the trajectory tracking error converges to a small neighborhood of zero within a predefined time, which can be explicitly set regardless of initial conditions. Comparative simulation results on a representative mechanical system are provided to demonstrate the superiority of the proposed controller, showcasing its faster convergence, higher tracking accuracy, and guaranteed constraint satisfaction compared to conventional finite-time and adaptive NN control methods. Full article

Background/Objectives: Parkinsonian gait is characterized by impaired motor adaptability, altered temporal organization, and reduced movement variability. While data augmentation is commonly used to mitigate class imbalance in gait-based machine learning models, conventional strategies often ignore physiological differences between healthy and pathological movements, potentially distorting meaningful motor dynamics. This study explores whether preserving healthy motor variability while selectively augmenting pathological gait signals can improve the robustness and physiological coherence of gait pattern classification models. Methods: Eight patients with Parkinsonian gait patterns and forty-eight healthy participants performed walking tasks on the Motigravity platform under hypogravity conditions. Full-body kinematic data were acquired using wearable inertial sensors. A selective augmentation strategy based on smooth time-warping was applied exclusively to pathological gait segments (×5, σ = 0.2), while healthy gait signals were left unaltered to preserve natural motor variability. Model performance was evaluated using a hybrid convolutional neural network–long short-term memory (CNN–LSTM) architecture across multiple augmentation configurations. Results: Selective augmentation of pathological gait signals achieved the highest classification performance (94.1% accuracy, AUC = 0.97), with balanced sensitivity (93.8%) and specificity (94.3%). Performance decreased when augmentation exceeded an optimal range of variability, suggesting that beneficial augmentation is constrained by physiologically plausible temporal dynamics. Conclusions: These findings demonstrate that physiology-informed, selective data augmentation can improve gait pattern classification under constrained data conditions. Rather than supporting disease-specific diagnosis, this proof-of-concept study highlights the importance of respecting intrinsic differences in motor variability when designing augmentation strategies for clinical gait analysis. Future studies incorporating disease-control cohorts and subject-independent validation are required to assess specificity and clinical generalizability. Full article

Hypoxia–ischemia (HI)-related brain injury impacts millions of neonates worldwide. Male neonates are two times more susceptible to developing HI. We have previously reported that the administration of the neurotrophin receptor tyrosine kinase B (TrkB) agonist 7,8-dihydroxyflavone (DHF) following neonatal HI increases hippocampal TrkB phosphorylation and improves hippocampal-dependent learning and memory in early adult life only in females. We hypothesize that sex differences in HI outcomes are due to alterations in neonatal hippocampal steroid content, mainly the neural testosterone. At postnatal day 9, C57BL/6J mice underwent sham and Vannucci’s HI surgeries and were treated either with DHF or vehicle control. Hippocampi and plasma were collected on days 1 and 3 post-HI and liquid chromatography tandem mass spectrometry was used to determine the testosterone (T), estradiol (E₂), progesterone (P₄), and corticosterone (CORT) contents in these samples. All hippocampal steroid contents were at least 10-fold higher than in plasma, suggesting neural synthesis. Males had higher hippocampal T content than females at 3 days post-HI. Treatment with DHF reduced T in the female hippocampi at 3 days post-HI, but not in males. These findings suggest that the neuroprotective effect of DHF in females may be mediated, at least in part, through the reduction in hippocampal T following HI. Full article

The widespread adoption of lithium-ion battery-powered electric vehicles has raised increasing concerns regarding battery safety under mechanical abuse conditions. However, mechanical abuse scenarios, such as battery extrusion, are highly diverse, making it impractical to conduct extensive destructive experiments and independent modeling for each specific scenario. In this work, a cross-scenario mechanical safety modeling framework for lithium-ion batteries is proposed based on transfer learning. Three quasi-static mechanical abuse tests, including flat-plate, rigid-rod, and hemispherical compression, are conducted on 18650 lithium-ion batteries. An equivalent mechanical model with a spring–damper parallel structure is employed to characterize the mechanical response and generate simulation data. Based on data from a single mechanical abuse scenario, a backpropagation neural network (BPNN)-based safety model is established to predict the maximum stress in the battery. The learned knowledge is then transferred to other mechanical abuse scenarios using a transfer learning strategy. The results demonstrate that, under limited target-domain data, the transferred models achieve stable prediction performance, with the average relative error controlled within 3.6%, outperforming models trained from scratch under the same conditions. Compared with existing studies that focus on single-scenario modeling, this work explicitly investigates cross-scenario transferability and demonstrates the effectiveness of transfer learning in reducing experimental and modeling effort for battery mechanical safety analysis. Full article

Non-alcoholic fatty liver disease (NAFLD) is a silent condition that can lead to fatal cirrhosis, with dietary factors playing a central role. The effect of various dietary interventions on male Wistar rats were evaluated in four diets: control, arsenic, sucrose, and arsenic–sucrose. SHG microscopy images from the right ventral lobe of the liver tissue were analyzed with a neural network trained to detect the presence or absence of collagen fibers, followed by the assessment of their orientation and angular distribution. Machine learning classification of SHG microscopy images revealed a marked increase in fibrosis risk with dietary interventions: <10% in controls, 24% with arsenic, 40% with sucrose, and 62% with combined arsenic–sucrose intake. Angular width distribution of collagen fibers narrowed dramatically across groups: 26° (control), 24° (arsenic), 15.7° (sucrose), and 2.8° (arsenic–sucrose). This analysis revealed four key statistical features for classifying the images according to the presence or absence of collagen fibers: (1) the percentage of pixels whose intensity is above the 15% noise threshold, (2) the Mean-to-Standard Deviation ratio (Mean/std), (3) the mode, and (4) the total intensity (sum). These results demonstrate that a diet rich in sucrose, particularly in combination with arsenic, constitutes a significant risk factor for liver collagen fiber remodeling. Full article

This study addresses the stability and quasi-synchronization of fractional-order neural networks that incorporate mixed delays, system uncertainties, and external disturbances. Accordingly, a more realistic neural network model is constructed. For fractional-order neural networks incorporating mixed delays and uncertainties (FONNMDU), this study establishes a criterion for uniform asymptotic stability and proves the existence and uniqueness of the equilibrium solution. Furthermore, it investigates the global uniform stability and stability regions of fractional-order neural networks with mixed delays, uncertainties, and external disturbances (FONNMDUED). Then, to address the quasi-synchronization problem, a controller is designed and some novel sufficient conditions for achieving quasi-synchronization are established. The results show that tuning the control parameters can adjust the error bound. These findings not only enrich the theoretical foundation of fractional-order neural networks but also offer practical insights for applications in complex systems. Full article

The study of muscle signal classification has been widely explored for the control of myoelectric prostheses. Traditional approaches rely on manually designed features extracted from time- or frequency-domain representations, which may limit the generalization and adaptability of EMG-based systems. In this work, an autoencoder-based framework is proposed for automatic feature extraction, enabling the learning of compact latent representations directly from raw EMG signals and reducing dependence on handcrafted features. A custom instrumentation system with three surface EMG sensors was developed and placed on selected forearm muscles to acquire signals associated with five hand movements from 20 healthy participants aged 18 to 40 years. The signals were segmented into 200 ms windows with 75% overlap. The proposed method employs a recurrent autoencoder with a symmetric encoder–decoder architecture, trained independently for each sensor to achieve accurate signal reconstruction, with a minimum reconstruction loss of $3.3\times {10}^{-4}{V}^2$. The encoder’s latent representations were then used to train a dense neural network for gesture classification. An overall efficiency of 93.84% was achieved, demonstrating that the proposed reconstruction-based approach provides high classification performance and represents a promising solution for future EMG-based assistive and control applications. Full article

The quality and safety of grain and oil food are paramount to sustainable societal development and public health. Implementing early warning analysis and risk control is critical for the comprehensive identification and management of grain and oil food safety risks. However, traditional risk prediction models are limited by their inability to accurately analyze complex nonlinear data, while their reliance on centralized storage further undermines prediction credibility and traceability. This study proposes a deep learning risk prediction model integrated with a blockchain-based traceability mechanism. Firstly, a risk prediction model combining Grey Relational Analysis (GRA) and Bayesian-optimized Tabular Neural Network (TabNet-BO) is proposed, enabling precise and rapid fine-grained risk prediction of the data; Secondly, a risk prediction method combining blockchain and deep learning is proposed. This method first completes the prediction interaction with the deep learning model through a smart contract and then records the exceeding data and prediction results on the blockchain to ensure the authenticity and traceability of the data. At the same time, a storage optimization method is employed, where only the exceeding data is uploaded to the blockchain, while the non-exceeding data is encrypted and stored in the local database. Compared with existing models, the proposed model not only effectively enhances the prediction capability for grain and oil food quality and safety but also improves the transparency and credibility of data management. Full article

Background/Objectives: Swimming requires precise motor control, sustained attention, and optimal cognitive–motor integration, making it an ideal model for investigating neural efficiency—the phenomenon whereby expert performers achieve optimal outcomes with reduced neural resource expenditure, operationalized as lower activation, sparser connectivity, and enhanced functional integration. This systematic review examined cognitive performance and neural adaptations in swimming athletes, investigating neuroimaging and behavioral outcomes distinguishing swimmers from non-athletes across performance levels. Methods: Following PRISMA 2020 guidelines, seven databases were searched (1999–2024) for studies examining cognitive/neural outcomes in swimmers using neuroimaging or validated assessments. A total of 24 studies (neuroimaging: n = 9; behavioral: n = 15) met the inclusion criteria. Risk of bias assessment used adapted Cochrane RoB2 and Newcastle–Ottawa Scale criteria. Results: Neuroimaging modalities included EEG (n = 4), fMRI (n = 2), TMS (n = 1), and ERP (n = 2). Key associations identified included the following: (1) Neural Efficiency: elite swimmers showed sparser upper beta connectivity (35% fewer connections, d = 0.76, p = 0.040) and enhanced alpha rhythm intensity (p ≤ 0.01); (2) Cognitive Performance: superior attention, working memory, and executive control correlated with expertise (d = 0.69–1.31), with thalamo-sensorimotor functional connectivity explaining 41% of world ranking variance (r² = 0.41, p < 0.001); (3) Attention: external focus strategies improved performance in intermediate swimmers but showed inconsistent effects in experts; (4) Mental Fatigue: impaired performance in young adult swimmers (1.2% decrement, d = 0.13) but not master swimmers (p = 0.49); (5) Genetics: COMT Val158Met polymorphism associated with performance differences (p = 0.026). Effect sizes ranged from small to large, with Cohen’s d = 0.13–1.31. Conclusions: Swimming expertise is associated with specific neural and cognitive characteristics, including efficient brain connectivity and enhanced cognitive control. However, cross-sectional designs (88% of studies) and small samples (median n = 36; all studies underpowered) preclude causal inference. The lack of spatially quantitative synthesis and visualization of neuroimaging findings represents a methodological limitation of this review and the field. The findings suggest potential applications for talent identification, training optimization, and mental health promotion through swimming but require longitudinal validation and development of standardized swimmer brain atlases before definitive recommendations. Full article

The performance of convolutional neural networks (CNNs) depends not only on model architecture but also on the structure and quality of the training data. While most artificial network interpretability methods focus on explaining trained models, less attention has been given to understanding how dataset composition itself shapes learning outcomes. This work introduces a novel framework that uses programmatically generated synthetic datasets to isolate and control visual features, enabling systematic evaluation of their contribution to CNN performance. Guided by principles from set theory, Shapley values, and the Apriori algorithm, we formalize an equivalence between CNN kernel weights and pattern frequency counts, showing that feature overlap across datasets predicts model generalization. Methods include the construction of four synthetic digit datasets with controlled object and background features, training lightweight CNNs under K-fold validation, and statistical evaluation of cross-dataset performance. The results show that internal object patterns significantly improve accuracy and F1 scores compared to non-object background features, and that a dataset similarity prediction algorithm achieves near-perfect correlation ($\rho =0.97$) between the predicted and observed performance. The conclusions highlight that dataset feature composition can be treated as a measurable proxy for model behavior, offering a new path for dataset evaluation, pruning, and design optimization. This approach provides a principled framework for predicting CNN performance without requiring full-scale model training. Full article