Search Results (1,705)

Natural products derived from plants and microorganisms remain promising alternatives to synthetic chemicals and conventional substances across a wide range of fields, including pharmaceuticals, agriculture, and industry. They also play an important role in the development of sustainable biopesticides and biofertilizers. Chemically, natural products can be grouped into overlapping structural and biosynthetic categories, including alkaloids, terpenoids, flavonoids, glycosides, saponins, and polyketides. Each group reflects distinct chemical characteristics and associated biological functions. This overview highlights the main findings from the Molecules Special Issue: “Natural Products: Isolation, Analysis and Biological Activity, 2nd Edition”, focusing on three categories: (i) plant protection, plant health, and plant biotechnology; (ii) functional foods and health-promoting formulations; and (iii) therapeutic natural products and derivatives. Exploring the mechanisms of action of natural products is essential for ensuring safety and optimizing sustainable resource use. This understanding drives critical innovations across drug discovery and materials science. Ultimately, such research reinforces their cross-disciplinary significance for advancing human health and promoting environmental sustainability. Full article

This work reviews the strategic valorization of industrial by-products as sustainable sources of biopolymers and bioactive compounds, promoting a circular economy through the efficient use of renewable resources and reducing waste generation. These strategies contribute to lowering the carbon footprint of conventional packaging and plasticulture while supporting more resilient and diverse agriculture systems. Special emphasis is placed on processing roots and tubers as renewable raw materials for the production of biodegradable films for agronomic applications as eco-friendly alternatives to petroleum-based plastics and contributing to soil and ecosystem protection. Additionally, the incorporation of by-products from yerba mate (Ilex paraguariensis) demonstrate significant potential as both matrix-forming and filler materials in biodegradable composites while also providing antioxidant activity and pH-sensing capacity. This sustainable framework is further expanded through the utilization of non-traditional species like rosehip (Rosa rubiginosa), Aloe vera (Aloe barbadensis), and topinambur (Helianthus tuberosus), which provide versatile functional matrices and bioactive compounds. Finally, the development of active and intelligent food packaging is addressed. Extracting natural pH-sensitive pigments from red cabbage and topinambur flowers enables the formulation of eco-friendly inks for real-time freshness monitoring. Ultimately, integrating these waste streams drives technological disruption, scaling sustainable, tailored solutions for global industry needs. Full article

As the global population ages rapidly, demand for safe and effective strategies to promote healthy aging grows markedly. Natural bioactive compounds, with favorable biosafety profiles and multi-target regulatory properties, have become a core focus in developing anti-aging functional foods and nutraceuticals. Amid the search for novel sustainable bioresources, insects emerge as promising anti-aging candidates for their rich species diversity, scalable production, low environmental footprint, and abundant unique bioactive components such as functional proteins and bioactive peptides. Based on bibliometric analysis of 500 eligible publications spanning two decades, this review systematically identifies 32 anti-aging insect species across seven orders, classifies their bioactive components into five major categories, summarizes green extraction technologies, and evaluates their in vitro and in vivo anti-aging activities centered on oxidative stress and inflammatory regulation, while outlining the field’s trajectory from basic mechanistic research to functional application. It further highlights core challenges including fragmented research frameworks and insufficient robust in vivo validation. Finally, it recommends integrating established food science and medical methodologies with emerging technologies such as omics, artificial intelligence, and advanced delivery systems to advance future research paradigms. These efforts could provide a strong theoretical foundation for the efficient and sustainable use of insect resources in anti-aging applications. Full article

The water rights trading market (WRM) acts as a policy tool to enhance water resources allocation efficiency. However, how WRM affects food production deserves further exploration. This study examines whether WRM affects food production and through which channels this effect may operate. Using WRM policy as a quasi-natural experiment, this study investigates the role of WRM in food production in China. The results show that WRM can expand the grain sown area and enhance the efficiency of production factor allocation, thus increasing food production. Meanwhile, the grain-increasing effect of WRM does not lead to excessive water consumption. The heterogeneity discussion shows that the impact of WRM is more obvious in the south and the regions with high disaster rates and abundant water resources. More importantly, compared with provincial WRM, national WRM plays a particularly positive role in increasing food production. Furthermore, the development of factor marketization can better exert the positive impact of WRM, but government intervention will weaken the positive impact of WRM. In short, these findings are valuable for developing countries to develop WRM and improve food security. Full article

Livestock production in Africa occurs across highly heterogeneous agroecological and management environments, ranging from extensive pastoral and mixed crop–livestock systems to intensive enterprises. These systems are characterized by seasonal and spatial variation in feed resources, reliance on locally available forage and agricultural by-products, climatic stress, endemic diseases, and the use of indigenous and locally adapted breeds. Such conditions create distinctive microbiome–host interactions that remain poorly represented in global livestock omics research. Although the gut microbiome is central to nutrient utilization, immune function, metabolic homeostasis, and resilience, the functional mechanisms linking microbial communities, diet, host physiology, and productivity in African livestock remain insufficiently characterized. African systems are particularly underrepresented in integrated microbiome–metabolomics datasets, longitudinal studies, and artificial intelligence (AI)-enabled predictive models, limiting the development of context-specific precision nutrition strategies. This review examines the integration of metabolomics and AI with microbiome and host data to advance precision livestock nutrition within an African and One Health context. It identifies both substantial constraints and strategic opportunities. Limited research infrastructure, high-quality regional datasets, computational capacity, and specialized expertise remain major barriers. Conversely, Africa’s diversity of livestock breeds, feed resources, agroecological conditions, and naturally occurring resilience phenotypes provides an important opportunity to identify microbiome–metabolite signatures associated with feed efficiency, disease resilience, climate adaptation, and product quality. Emerging metabolomics and computational capacity, particularly in South Africa, could support regional research networks and continental data infrastructures. Furthermore, the review proposes an Africa-specific approach that develops locally grounded, scalable, and resource-sensitive precision nutrition strategies, strengthening antimicrobial stewardship, animal health, food safety, climate resilience, sustainable livestock production, and broader One Health objectives. Full article

Phosphogypsum (PG), a gypsum-rich by-product of wet-process phosphoric acid production, is increasingly considered for land application because it can supply calcium and sulfur and alleviate constraints such as sodicity, subsoil acidity, and vegetation establishment limitations. However, PG may also contain residual acidity, soluble salts, fluoride, heavy metals, and naturally occurring radionuclides, creating multiple exposure pathways. This critical review distinguishes direct PG evidence from gypsum or sulfate analogue evidence, life cycle assessment/material flow analysis evidence, and risk control studies. It evaluates PG land application according to receiving soil conditions, diagnosed constraints, exposure pathways, and environmental safety boundaries. The strongest evidence supports use in diagnosed sodic and saline–sodic soils, whereas applications in Al-toxic acid subsoils, flooded paddy systems, contaminated or degraded soils, and non-food vegetated systems require conditional assessment. PG should therefore be treated as a context-specific management option rather than an unrestricted disposal route. By linking waste valorization with soil demand, source quality, exposure control, and long-term monitoring, the proposed framework contributes to sustainability by integrating circular resource use with soil health, water protection, food/feed safety, and risk-informed governance, while helping to prevent the transfer of environmental burdens across ecosystems or generations. Full article

Frankincense, a natural resin obtained from Boswellia species, has been extensively utilized in traditional medicine and has attracted significant attention in biomedical applications owing to its vast therapeutic effects. While many studies and reviews have reported its pharmacological and biomedical applications, its potential in broader engineering domains and material science remains less explored. In biomedical engineering, frankincense-based compounds have been successfully incorporated into several matrices including hydrogels, nanomaterials, scaffolds, coatings for tissue engineering, food preservation and functional textiles. Frankincense has also exhibited significant potential as a functional component in engineering materials and environmental applications including its significant effects as a green corrosion inhibitor, drilling-fluid modifier and adsorbent materials. This review also highlights the economic aspects of frankincense utilization by evaluating and comparing its production, market value and scalability with other natural resin and gums. Additionally, environmental and sustainability factors associated with frankincense production, harvesting practices and resource availability have also been discussed. Overall, this review provides an overview of frankincense’s potential in diverse engineering applications and highlights the transition of frankincense from a traditional medicinal resin to a promising bio-based material for biomedical, material and environmental engineering applications. Full article

For decades, industrial trans fatty acids (iTFAs) have remained a critical focus of the scientific community, the food industry, and regulatory authorities because of their well-established role in the development of cardiovascular diseases, metabolic disorders, and chronic systemic inflammation. Rather than providing a descriptive overview, this review critically synthesizes current evidence on the elimination of industrial TFAs by integrating health, technological, regulatory, and sustainability perspectives into a comprehensive interdisciplinary analysis. The review outlines the biochemical characteristics and dietary sources of trans fatty acid isomers, highlighting the continuing scientific debate regarding the differential health effects of industrially produced and naturally occurring ruminant-derived TFAs. It also examines the evolution of scientific evidence that led to major regulatory actions by international organizations, including the World Health Organization (WHO) and the European Commission, resulting in legally binding restrictions that have substantially reduced industrial TFA intake and improved public health. Particular emphasis is placed on the critical assessment of current fat reformulation strategies, considering not only their technological functionality but also their nutritional quality, long-term metabolic implications, and contribution to sustainable food systems. Full hydrogenation, fractionation, chemical and enzymatic interesterification, and oleogelation are comparatively evaluated with respect to their advantages, limitations, and potential technological, nutritional, and environmental trade-offs. In addition, lipid microencapsulation is discussed as an emerging strategy for protecting oxidation-sensitive polyunsaturated fatty acids (PUFAs), thereby facilitating their incorporation into functional foods while maintaining nutritional quality. Unlike previous reviews that primarily focus on health outcomes or individual processing technologies, this review systematically integrates the sustainability dimensions of alternative fat modification approaches, including resource efficiency, energy consumption, clean label product development, and circular economy principles. Furthermore, it identifies current knowledge gaps related to the long-term metabolic safety, industrial scalability, and environmental performance of emerging lipid technologies. By combining these complementary perspectives, the review provides a comprehensive interdisciplinary synthesis that supports evidence-based fat reformulation and offers practical guidance for researchers, food manufacturers, and policy makers seeking to develop safer, nutritionally improved, technologically functional, and environmentally sustainable lipid systems. Full article

Global food systems must balance productivity with environmental sustainability amid climate change, geopolitical shocks, and unevenly distributed natural resources. This study introduces the Food Supply Sustainability Index (FSSI), a transparent, composite measure of the sustainability of a nation’s food production including international trade, and future climate-driven trade dynamics, with a distance-to-target method. Using FAO and IFPRI data, the FSSI categorises countries into five sustainability classes across three pillars: carbon footprint, soil degradation, and water stress. The results show high-income countries produce food less sustainably, while low-income countries do so more sustainably yet are more vulnerable to climate change and trade disruptions. The FSSI therefore recognises that trade redistributes rather than removes environmental risk, creating a more evenly distributed yet persistent global vulnerability to shocks. Under future climate scenarios, the index identifies that sustainability worsens in poorer regions, especially Sub-Saharan Africa, exposing countries to food insecurity. By combining multiple environmental dimensions into a single metric, the FSSI enables countries to benchmark sustainability performance and identify priority areas for intervention. The FSSI supports policies such as aligning imports with sustainability criteria, diversifying suppliers toward lower-impact origins, and supporting sustainable intensification in low-income settings. The FSSI provides a replicable, policy-relevant tool to assess, compare, and communicate global food system sustainability. Full article

Against the backdrop of increasing global food security pressures and tightening resource–environment constraints, enhancing grain production efficiency has become a focal international concern. Based on panel data from 16 cities in Shandong Province, China, spanning 2013 to 2022, this study employs the DEA–Malmquist index, SBM model, and Spatial Durbin model to measure grain production efficiency and analyze its spatiotemporal evolution and influencing factors. The findings reveal that Shandong’s grain production efficiency has generally improved but exhibits a spatial differentiation pattern of “higher in Western Shandong, lower in Eastern Shandong,” with significant positive spatial correlation and agglomeration effects. Mechanization significantly boosts efficiency, while urbanization, excessive fertilizer and pesticide use, and labor surplus exert notable negative impacts. This research clarifies the spatial spillover mechanisms and key constraints of efficiency, providing scientific evidence and practical guidance for optimizing agricultural resource allocation, promoting regional collaborative innovation, and formulating differentiated food security policies in Shandong Province and other regions with similar natural–economic conditions. Full article

The Karditsa region of Central Greece hosts a rich diversity of woody plant species that represent valuable sources of bioactive phytochemicals with significant ecological, nutritional, and industrial importance. This review provides a comprehensive overview of the phytochemical composition, biological activities, and bioeconomic potential of five selected woody species occurring in the region, namely Rosa canina, Cornus mas, Rubus fruticosus, Prunus spinosa, and Satureja montana. Particular emphasis is placed on the occurrence of phenolic compounds, flavonoids, anthocyanins, tannins, terpenoids, and essential oils, which are responsible for a wide range of biological activities, including antioxidant, antimicrobial, anti-inflammatory, and neuroprotective effects. Current extraction technologies and analytical approaches used for the recovery and characterization of these bioactive compounds are also discussed, highlighting recent advances in green and sustainable extraction methods. Furthermore, the potential applications of these plant-derived metabolites in functional foods, nutraceuticals, pharmaceuticals, cosmetics, and other bio-based products are critically evaluated. Finally, the review discusses the importance of conserving regional plant biodiversity while promoting the sustainable utilization of natural resources through environmentally responsible valorization strategies. By integrating available phytochemical, biological, and applied research, this review provides an updated synthesis of the scientific evidence and identifies future research directions for the sustainable exploitation of selected woody flora from the Karditsa region. Full article

With the rapid development of the Thai economy and the continuous improvement of national living standards, the Thai people’s demand for freshness, quality, and diversity of agricultural products is constantly increasing. Efficient agricultural product logistics can not only ensure the supply and quality of agricultural products, but also promote the optimization of resource allocation and logistics infrastructure construction, with direct implications for reducing food loss, lowering energy consumption, and enhancing the resilience of regional food systems—key dimensions of sustainable agricultural development. In order to analyze the development status of agricultural product logistics in Thailand, the paper constructed an evaluation system consisting of four dimensions and seven indicators. Factor analysis and natural break point method were used to measure the development level of agricultural product logistics in 77 provinces of Thailand from 2012 to 2023, and the spatial pattern evolution characteristics were analyzed. The research conclusion is as follows: (1) From 2012 to 2023, the comprehensive score of agricultural product logistics in Thailand increased from 24.01 to 30.89, indicating a significant enhancement in overall strength; (2) the logistics level of agricultural products in various provinces of Thailand shows heterogeneous characteristics; (3) by calculating the strength of agricultural product logistics attraction between cities, the Central Plains Agricultural Product Logistics Circle centered on Bangkok, the Northern Plains Agricultural Product Logistics Circle centered on Chiang Mai Province, and the Southern Logistics Circle centered on Pattani and Yala provinces were determined. Full article

Natural mineral water standards use compositional criteria to define product identity and distinguish natural mineral water from other drinking water categories. China’s National Food Safety Standard—Drinking Natural Mineral Water (GB 8537) specifies seven alternative minimum threshold parameters for this purpose. This study assessed how these parameters function in four dimensions: regulatory identity, hydrogeological resource recognition, health-related interpretation, and label-based market communication. We compared major international regulatory frameworks, qualitatively synthesized health-related evidence, reviewed representative source-scale hydrogeological evidence from China, and analyzed label information from 150 commercial products. China’s system differs from the Codex and European Union frameworks, which emphasize source authenticity, compositional stability, permitted treatment, and disclosure, and from the United States system, which primarily defines mineral water by total dissolved solids. Regional studies showed that mineral water composition reflects site-specific combinations of lithology, geological structure, recharge, groundwater circulation, and water–rock interaction. The same parameter may occur in more than one hydrogeological setting, whereas different parameters within one groundwater system may arise through distinct geochemical processes. Health-related evidence varies substantially and should not be interpreted as establishing consumer health claims. In the label survey, metasilicic acid, TDS, and strontium were the most frequently declared parameters, while zinc and free carbon dioxide were less frequently declared. We propose a functional framework that distinguishes statutory identity, hydrogeological resource, health/safety, sensory/technical, and consumer-communication roles. This framework clarifies why the seven parameters should not be treated as functionally equivalent and provides a basis for refining natural mineral water standards and label communication. Full article

Global climate change has posed a serious threat to agricultural production and food security. Crop growth models, with their excellent simulation and prediction capabilities, have become one of the important tools for guiding agricultural production and ensuring food security. This study provides a review of the research progress in crop growth models. The development history of the models is summarized into four stages, including process modeling, system simulation, model application, and algorithm expansion. According to different driving factors, the crop growth models can be categorized into solar radiation-driven, soil moisture content-driven, meteorological factor-driven, and integrated factor-driven models. In terms of the countries of development, the models mainly include those from the Netherlands, the United States, Australia, and China. Regarding applications, crop growth models are primarily applicable to adaptability assessment, agricultural resource and crop cultivation management, and climate change evaluation. Since their initial development, these models have enhanced their mechanistic nature through various approaches, such as incorporating surface mulching modules, considering the response of root water uptake to soil salt stress, and preliminarily introducing physiological regulation processes. By integrating with remote sensing technology, the spatial scale of the models has been expanded from the point scale to the regional or even global scale, and the accuracy of regional-scale yield estimation has been significantly improved through assimilation with remote sensing. Meanwhile, crop growth models have also been combined with intelligent algorithms to optimize irrigation scheduling, and to perform model parameter optimization. Looking forward, potential future research directions of crop growth models include extending the soil submodule from one-dimensional to two/three-dimensional water–heat–solute transport, moving toward a more mechanistic crop growth modeling, integration with remote sensing, and incorporating artificial intelligence. This study serves as a reference for further development and application of crop growth models, and provides technical support for the development of sustainable agriculture. Full article

Food security faces significant challenges due to the growing threat of insect pests and global climate change, making it essential to adopt sustainable agricultural strategies. Plants possess intrinsic defense systems that are activated in response to herbivore attack, including the emission of specialized volatile organic compounds (VOC) known as herbivore-induced plant volatiles (HIPVs). These volatiles aid the foraging of natural enemies (predators and parasitoids), thereby contributing to biological control of pest populations. Harnessing these chemical defense mechanisms offers a promising avenue for pest management, although natural enemy attraction does not necessarily result in pest suppression or increased crop yield. This review synthesizes plant and insect-derived chemical signaling mechanisms with direct relevance to biological control in crop agroecosystems, including field crops, orchards, vegetable systems, and protected cultivation. We emphasize recent applied research while retaining selected foundational studies that established the principal concepts and mechanisms underlying chemically mediated pest management. Considering the importance of chemical signaling in sustainable agriculture, we propose four key research directions: (1) optimizing plant defense induction mechanisms; (2) integrating HIPVs with natural enemy pheromone-based attractants; (3) combining habitat management with the provision of plant-derived food resources; and (4) harnessing plant defenses through breeding and infochemical-based genetically modified crops. Additionally, we examine the potential impacts of environmental stressors on plant–herbivore chemical communication, underscoring their importance for resilient and environmentally sustainable agricultural systems. Full article