Search Results (4,180)

Close-distance multi-seam mining frequently induces secondary surface deformation and subsidence. Extracting a lower coal seam beneath an existing goaf repeatedly disturbs the overburden, often leading to roof collapse and the expansion of vertical water-conducting fractures that connect the working face to aquifers. Furthermore, the overlying goaf increases the risk of water inrush into active lower workings. This study investigates the mechanisms of strata reactivation and fracturing within an overlying goaf during lower seam extraction at a mine in Northwest China. Using theoretical analysis, numerical simulation, and microseismic monitoring, the research examines the secondary fracture mechanisms of the goaf roof and the resulting water-inrush potential. Research Findings: Strata Instability: Analysis of the key sandstone strata indicates that subsidence (W) of the key rock blocks satisfies 3.17 < W₁ = 4.61 m < 18 m for the lower seam and 3.17 m < W₂ = 5.31 m < 69.6 m for the 3-1# seam. These values confirm that key rock blocks in the basic roof undergo “reactivated” instability following fracture during lower seam mining. Pressure Relief and Fluid Dynamics: Mining-induced fracture initiation and propagation trigger strata reactivation. As the distance to the center of the goaf decreases, the subsidence of the overburden increases, ultimately resulting in a “trapezoidal” bending deformation pattern. Due to secondary activation, the roof subsidence 30 m above the 221 coal seam increased from 1.89 m to 5.475 m. The layers of high-strength, medium-grained sandstone and siltstone overlying the 317 coal seam and beneath the 221 goaf serve as high-strength material for the overlying rock formations. This suppresses the development of the caving zone and fracture zone, leading to subsidence failing to reach the sum of the heights of the two coal seams (6.8 m) and only reaching a value of 5.475 m. During extraction, the stress field undergoes a distinct evolution: it transitions from an initial “regular triangular” pressure-relief zone into a tripartite “weak–strong–strong” distribution. Furthermore, fluid discharge in the overlapping zone between the 317 working face and the 221 goaf increased sequentially, displaying an “alternating” pattern of peak vector variations as the face advanced. Microseismic Activity: Monitoring within the 300–500 m range identified frequent low-energy events and high-magnitude events (10⁴ J, 10⁵ J). These findings demonstrate that secondary excavation directly impacts the aquifer, creating a significant water-inrush hazard for the active working face. Full article

Constrained by the layout and air volume of coal mine ventilation systems, the efficiency of diluting CO through ventilation during excavation blasting is relatively low, rendering it difficult to reduce or eliminate CO at the source. Based on the precipitation method, this study developed a copper–manganese–tin (Cu-Mn-Sn) catalyst. The elimination performance of the water-resistant Cu-Mn-Sn catalyst was quantitatively characterized in terms of catalytic activity and instantaneous reaction rate. Moreover, an in situ CO elimination method for blasting at excavation faces was proposed. Based on the segmented integrated blasting hole structure design, a catalyst cartridge for CO elimination in blasting holes was developed. Field tests were conducted at the Xinbai Coal Mine of Huating Coal Industry Group in China, and the influences of the weight and arrangement mode of the catalyst cartridge on CO elimination efficiency were investigated. The experimental results demonstrate that when the mass of the catalyst cartridge is 35 g and the “dual-end charge” structure is employed, a CO elimination efficiency of 51.5% can be achieved, offering a practical and feasible active prevention and control scheme as well as a theoretical paradigm for CO control in coal mine excavation blasting. Full article

Despite significant advances in oncology, current cancer therapies remain constrained by toxicity, resistance, and limited selectivity. Endophytic fungi symbiotic microorganisms inhabiting plant tissues represent a sustainable and underexplored source of structurally diverse anticancer metabolites. These include alkaloids, terpenoids, polyketides, and peptides that disrupt microtubule dynamics, interfere with DNA replication, and induce mitochondrial-mediated apoptosis. They also modulate key oncogenic signalling pathways such as nuclear factor kappa B (NF-κB), signal transducer and activator of transcription 3 (STAT3), and phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt), thereby enhancing the efficacy of existing chemotherapies. Endophyte derived compounds further inhibit angiogenesis, suppress metastasis, and stimulate immune responses, offering multi-target mechanisms with reduced toxicity. This review examines strategies that enhance the discovery and yield of these bioactive metabolites, including One Strain Many Compounds (OSMAC), microbial co-culture, epigenetic activation, genome mining, and synthetic biology. A comparative assessment of endophyte-derived versus conventional anticancer agents highlights their potential for scalable, eco-sustainable production. Collectively, endophytic fungi are positioned as promising contributors to the next generation of accessible, cost-effective, and environmentally responsible anticancer therapies. Full article

Ochratoxin A (OTA) is a globally distributed mycotoxin that poses serious threats to food safety and human health due to its nephrotoxic, hepatotoxic, and carcinogenic properties. Previous enzymatic detoxification strategies for OTA have been constrained by low degradation efficiency or poor soluble expression of highly active enzymes. In this study, a bacterial strain with strong OTA-degrading activity was isolated and identified as Acinetobacter kookii AK4, which degraded 95.44% of 1 μg/mL OTA within 6 h. The predominant OTA-degrading activity was derived from intracellular enzymes. Through genome mining and experimental validation, gene2102 was identified as encoding an amidohydrolase. The enzyme was designated AMH2102 and was heterologously expressed in Escherichia coli. Codon optimization combined with fusion of an N-terminal SUMO tag increased the soluble expression of AMH2102 by 14.81-fold, enabling complete (100%) OTA degradation within 3 min. Overall, this study achieved the identification of an efficient OTA-degrading strain and enzyme and explored strategies for improving enzyme expression, yielding effective outcomes that provide useful references for future studies on strain mining and enzyme engineering. Full article

Graphite is a critical mineral used to produce anodes for lithium-ion batteries (LIBs). Battery-grade anode active material (AAM) is derived from natural graphite. As the electric vehicle (EV) market continues to expand across North America, establishing a local AAM supply chain has become increasingly important. This new supply chain must be sustainable if critical minerals are to replace the internal combustion engine (ICE) powertrain in vehicles. Canada possesses abundant critical mineral resources, including natural graphite, which is mined and processed in the province of Québec. To better understand the environmental implications of this emerging supply chain, a life cycle assessment (LCA) was conducted on a Québec-based graphite mine and processing facility. The results showed that producing one ton of AAM in Québec generates approximately 1.44 tons of CO₂-equivalent (long-term) emissions, significantly lower than the 9.6 tons of CO₂ emitted per ton of graphite produced in China. Natural gas used for purification and coating at the process plant was the largest contributor of CO₂ in this study. Although this LCA in Québec represents a substantial reduction in carbon intensity, further opportunities must be explored to enhance sustainability and strengthen North America’s graphite supply chain. Full article

A study on the sources, bioconcentration, and translocation of heavy metals in Haloxylon ammodendron in the Eastern Junggar Coalfield, Xinjiang, China, was conducted and evaluated. The quantities of Pb, Cd, and Cr were 1.2, 22.5, and 1.9 times higher than the baseline values of Xinjiang soils, respectively. The mean concentrations of these heavy metals in the rhizosphere soil of Haloxylon ammodendron were 48.81, 17.74, 93.25, 3.32, 29.05, and 26.95 mg/kg. The exceedance rates for Cd, Cr, and Pb in bare soil were 100%, 99.03%, and 75.73%, respectively, indicating significant accumulation of heavy metals, with Cd demonstrating the highest enrichment degree. Most sampling sites showed moderate pollution according to the Pollution Load Index (PLI). Meanwhile, the Pollution Index (PN) indicated elevated pollution levels at all the sampling sites, with Cr identified as the first contaminant. The absolute principal component score–multiple linear regression (APCS-MLR) model revealed three principal sources of heavy metal pollutants in soil: 44.2% from natural processes and mining activities, 22.7% from industrial coal combustion and sewage, and 33.1% of undetermined origins. The bioconcentration factors (BCFs) and translocation factors (TFs) revealed Haloxylon ammodendron to have clear accumulation and translocation abilities with respect to these heavy metals. The fuzzy membership function showed that the overall assessment score for Haloxylon ammodendron was 9.1325, indicating the substantial remediation potential of Haloxylon ammodendron for heavy metal pollutants, especially for Cd. Furthermore, Haloxylon ammodendron demonstrated substantial Pb and Cr accumulation and remediation ability. Haloxylon ammodendron exhibited remarkable heavy metal accumulation and translocation abilities, making it a suitable tool for phytoremediation in the study area. The findings of this study will prove useful in promoting and implementing sustainable mining practices and safeguarding regional ecological security and may contribute to advancing local ecological conservation and social economic development. Full article

Mining-resource-based cities, as distinctive human–environment systems, face urgent challenges from intensified urbanization and mining, leading to land imbalance and ecosystem service degradation. To enhance resilience, it is essential to identify the evolution and drivers of ecosystem services and construct targeted ecological compensation models. This study focuses on Xinzhou, a representative mining city in China, and systematically analyzes three aspects: (1) spatiotemporal dynamics of land use and ecosystem service value (ESV) from 2000 to 2023 using Markov chains, equivalent factor method, hotspot and sensitivity analyses; (2) identification of ESV driving mechanisms through an integrated “stepwise regression + geographical detector” framework; and (3) formulation of ecological compensation models via quantification of priority indices, demand intensity coefficients, and compensation standards. Key findings indicate that land conversion was concentrated in coalfield zones and surrounding built-up areas, involving 2,518,341.75 hm² (35.76% of total area), primarily characterized by a reduction in farmland and expansion of forest, grassland, and construction land. ESV showed a striped spatial pattern, with higher values in mountainous zones and lower values in valleys and basins with frequent human activity. The northwest coalfield region experienced an initial decline followed by a recovery in ESV. Annual mean temperature emerged as the dominant driver, while DEM influence increased annually. All factor interactions exhibited synergistic effects, with natural variables exerting greater influence than socio-economic ones. Ecological compensation demand was high overall, especially in Wutai, Kelan, and Pianguan counties, with high-value compensation areas mainly distributed in the eastern and central parts of Xinzhou. Looking ahead, a compensation framework prioritizing ecological–economic optimization should be developed, guided by zoned, typological, and dynamic configurations. By analyzing ecosystem governance from the perspective of a mining-resource-based city, this study enhances global ecosystem service evaluation frameworks and offers a replicable model to advance transnational ecological cooperation and green urban transformation. Full article

Coal mining in plain regions and its related surface subsidence and geological hazards have been extensively studied, whereas research on mining-induced hazards in mountainous areas remains limited. This knowledge gap has contributed to the frequent occurrence of mining disasters, particularly under steep ridge-type mountain geometry, where deformation characteristics, large-scale slope failure risks, and mining-induced hazard mechanisms remain poorly understood. In this study, a mining area in Zhenxiong, Zhaotong, Yunnan Province, China, is investigated using SBAS-InSAR, GNSS observations, UAV surveys, optical satellite imagery, and detailed field investigations. Surface hazards triggered by coal extraction are identified, and the response relationship between surface subsidence and mining activities is analyzed to reveal the development mechanisms of surface deformation beneath steep ridge-type mountain geometry. The results show that: (1) deep coal mining can still induce significant surface deformation due to the combined amplification effects of steep slopes and lithological conditions; (2) mining-induced deformation does not necessarily evolve into large-scale slope collapse and may gradually stabilize through natural adjustment processes; (3) SBAS-InSAR, validated by GNSS and field observations, provides an effective approach for detecting mining-related subsidence; (4) surface deformation in the study area is jointly influenced by multiple working faces; and (5) strong coupling between the unique steep ridge-type mountain geometry and underlying coal extraction leads to a compound disaster chain under multi-source interactions. These findings offer a critical scientific understanding of mining-induced deformation beneath steep ridge-type mountain geometry and provide important guidance for geological hazard prevention and control in similar mountainous mining areas. Full article

The accelerated closure of hard coal mines across Europe contrasts with Poland’s continued structural reliance on coal extraction and coal-based power generation, increasing the urgency of credible post-mining development models. This article investigates the potential transformation of the end-of-life Bobrek coal mine in Bytom (Poland), drawing on methodological and business-model insights from the European Union (EU) Research Fund for Coal and Steel (RFCS) POTENTIALS and GreenJOBS projects. A combined methodological framework is applied, including structural analysis to identify key transformation variables, morphological analysis to explore alternative redevelopment pathways, and multicriteria assessment to configure coherent scenarios integrating renewable energy systems and circular-economy activities. The results show that an industrial eco-park backed by a virtual power plant (VPP), comprising photovoltaic installations, a mine-water-based geothermal heating system, and small-scale wind turbines, is technically feasible and environmentally sustainable. In parallel, three circular-economy business lines, the recycling of end-of-life photovoltaic panels, waste electrical and electronic equipment (WEEE), and refrigeration units, were assessed as possible economic cores of the envisaged eco-park. Overall, the proposed model enables effective reuse of mining infrastructure, supports low-emission industrial activity, and aligns with EU climate policy objectives. The Bobrek site may serve as a reference for post-mining redevelopment in other coal regions. Full article

Chemosensory proteins (CSPs) are found in the olfactory sensory organs (antennae and maxillary palps) and/or gustatory sensory organs (labellum and legs) and have long been accepted to function through the binding of odorants. However, the same CSPs are also expressed in many tissues other than olfactory and gustatory organs, such as the gut, brain, fat body, wing, epidermis, Corpora allata, salivary gland, pheromone gland, prothoracic gland, etc. In this report, we suggest renaming the “chemosensory protein (CSP)” the “4-Cysteine Soluble Protein (4CSP)”. This paradigm and nomenclature shift is based on molecular characteristics, genomic mining, tissue distribution, and functional roles beyond those related to olfaction. We examined prior studies on this protein gene family to bolster the renaming, highlighting the most recent findings that we ascribe to “pleiotropic properties” and evolutionary relevance rather than smell. The scope of the report, per se, is broad, and this is especially true given the volume of data that has been gathered on 4CSP expressed in ways that are not consistent with the olfactory paradigm. Statements outlining the many chemosensory properties of 4CSPs, particularly how they activate olfactory receptor neurons (ORNs), are currently scarce, if they exist at all. Many debates currently focus on 4CSPs’ non-chemosensory functions, which are backed by a multitude of evidence, from gene evolution to tissue distribution. Therefore, strong arguments in favor of renaming chemosensory proteins are becoming evident here, outweighing the drawbacks. Full article

This study investigated the effects of Potentilla fruticosa planting on plant community succession in a spoil heap, analyzed changes in soil enzyme activities under different planting methods, and explored the relationships between soil enzyme activities and plant community diversity across these planting approaches. This experiment selected Potentilla fruticosa planted under different restoration modes (covered with soil, covered with straw curtain, not covered) in Shuanglonggou gangue Mountain, Tianzhu County, Gansu Province, as the research object. The growth status and activities of soil urease, alkaline phosphatase, catalase and sucrase and their correlation were measured in different repair modes in the untreated waste rock (CK). The results showed that (1) the Simpson dominance index and Pielou evenness index decreased to a certain extent under the condition of plant community analysis; Shannon diversity index decreased in the case of curtain covering, but increased in the other two treatments. The richness index of Margalef increased to some extent, and reached the maximum when the curtain was covered. (2) The activity of soil urease and alkaline phosphatase was the lowest in the plots covered by straw curtain, and the activity was 104.4 μg/d/g and 334.5 μg/d/g, respectively. (3) The change in soil catalase activity was not obvious with the increase in soil depth, and the catalase activity in deep soil reached the maximum of 945.3 μg/d/g in the mulch soil sample. (4) The planting of golden dew had a certain effect on the activity of sucrase in shallow soil, and the maximum sucrase activity reached 15.3 μg/d/g under the condition that the planting of Potentilla fruticosa was not covered. (5) Soil urease activity and soil alkaline phosphatase activity were significantly positively correlated with plant community diversity index, while soil catalase activity and soil sucrase activity were negatively correlated with plant community diversity. (6) The total nitrogen content in the soil shows a significant positive correlation with soil urease activity. While soil alkaline phosphatase activity is significantly negatively correlated with soil moisture content, it shows a highly significant positive correlation with soil total nitrogen content. Furthermore, soil sucrase activity demonstrates a highly significant positive correlation with soil bulk density and soil available phosphorus content. To sum up, the planting of golden plum can promote the ecological restoration of gangue mountain soil, and provide a theoretical and scientific basis for ecological restoration and soil quality improvement in the Qilian Mountain mining area. Full article

Stochastic Process Mining, in particular, Markov processes, is used to represent uncertainty and variability in Activities of Daily Living (ADLs). However, the Markov models inherently assume that the time spent in each state must follow an exponential distribution. This presents a significant challenge to model real-life complexities in ADLs. Therefore, this paper employs semi-Markov models on publicly available ADL event logs to model state durations, where results are validated via goodness-of-fit tests (Kullback–Leibler, Kolmogorov–Smirnov, Cramér–von Mises). Synthetic durations are generated using the inverse transform sampling technique. To simulate dementia-based behaviours, the weights of the mixture model are altered to reflect prolonged duration in napping, toileting, meal, and drink preparation. These anomalies are then detected through the employment of log-likelihood ratio and chi-square tests. Experimental results demonstrate that the proposed approach can be used to reliably identify abnormal ADL durations, offering a proven framework to track early detection of behavioural shifts, and showcasing the effectiveness of detecting duration-based anomalies in ADL. By identifying such anomalies, our work aims to detect deterioration in the smart home resident’s condition, focusing in particular on their ability to execute different ADLs. Full article

In the context of deep mining and green low-carbon transition, this study characterizes the thermo-mechanical evolution and fracture mechanisms of cemented tailings backfill (CTB) through systematic experiments conducted at 20–60 °C across 3–28 days. Results demonstrate that strength and elastic modulus follow a unimodal dependence on temperature, peaking at 40 °C. Gaussian modeling reveals that curing times narrow the thermal tolerance window, with the elastic modulus exhibiting higher sensitivity to overheating. A consistent “pre-peak activity window” is identified in AE responses, characterized by b-value drops and an increase in tensile event proportions from 66% to 83%. A composite AE damage index (ADI) is introduced to systematically precede macroscopic failure, with thresholds of ADI ≥ 0.60 and 0.70 indicating accelerated crack propagation and imminent instability, respectively. Microstructural analysis confirms that 40 °C promotes C-S-H and fine ettringite bridging, whereas temperatures ≥ 50 °C induce Ca(OH)₂ coarsening and enhanced pore connectivity, triggering early tensile-dominated degradation. This study establishes a “temperature → hydration/porosity → AE response → mechanical evolution” pathway, providing an optimal curing window of 40 ± 5 °C and an ADI-based early-warning criterion for temperature-adaptive CTB design and on-site safety management. Full article

Brassica crops (genus Brassica) represent globally important vegetables and oilseeds, yet are continuously threatened by insect pests that reduce yield and quality. While classical physiological and chemical defense mechanisms such as the glucosinolate–myrosinase system have been well documented, recent advances in genomics and molecular biology are beginning to unravel the genetic basis of insect resistance in Brassica species. Notably, emerging evidence highlights the central role of jasmonic acid (JA) signaling and the transcription factor MYC2 as a master regulator of inducible defense responses, where stress-induced degradation of JAZ repressors releases MYC2 to activate downstream defense genes and secondary metabolite biosynthesis. This review synthesizes the current understanding of defense mechanisms in Brassica against herbivores, highlights identified resistance genes and their functional roles, and examines the knowledge gaps that hinder progress in molecular breeding. We then explore future molecular approaches including high-throughput omics, gene editing, and resistance gene mining that hold promise for designing durable insect-resistant Brassica cultivars. To our knowledge, major insect resistance loci are relatively scarce compared to pathogen-resistant loci. We argue for integrated strategies combining classical breeding, biotechnology, and ecological management to accelerate the development of resilient Brassica germplasm. Full article

Decarbonization of the concrete industry has arisen as one of the main priorities for the construction sector in order to mitigate the negative climate impact associated with construction. The carbon emissions of concrete mainly originate from the production of cement, and it is essential to find supplementary cementitious materials (SCMs) to achieve eco-friendly construction materials. The use of tailings as SCMs could reduce the carbon footprint of concrete, as well as improve the environmental impact of waste management within the mining sector. To investigate the effects of using lead–zinc tailings as a partial replacement for ordinary Portland cement (OPC), an experimental study was conducted. Two types of lead–zinc tailings were utilized in the experiments to replace 10% and 20% of OPC. A mechanical activation method was adopted using a vibratory cup mill. The effects of activation on the tailings’ particle size distributions and mineralogy were evaluated. The results indicated that the activation was insufficient to promote the pozzolanic activity in T1 and only partially promoted it in T2. A total of 18 different tailing-based mortar (TBM) specimens were produced from the raw and activated tailings, and their flowability, setting time, and compressive strengths after 7, 28, and 90 days were evaluated. The microstructures of the specimens were analyzed using scanning electron microscopy with energy dispersive X-ray spectroscopy. No alteration of mineralogy was observed in T1 after activation; however, a reduction in muscovite was observed in T2. The TBM specimens with 10% activated tailings exhibited comparable 28-day compressive strengths to the control specimen. For the replacement level above 10%, there was a loss of compressive strength at 28 days, both for the activated and raw tailings and for both T1 and T2. Evaluation of the microstructure showed that the use of tailings caused regions in the cement matrix with high metal concentrations. Microcracks could be observed in or around such grains in several cases. The study demonstrated that 10% of OPC can be replaced by lead–zinc tailings while retaining the compressive strength of the specimens. Full article