Search Results (273)

This study presents a unified parametric optimization framework for the thermal design of microchannel spreaders used in high-power processor cooling. The fin geometry is expressed in a shape-agnostic parametric form defined by fin thickness, top and bottom gap widths, and channel height, without prescribing a fixed cross-section. This approach accommodates practical fin profiles ranging from rectangular to tapered and V-shaped, allowing continuous geometric optimization within manufacturability and hydraulic limits. A coupled analytical–numerical model integrates conduction through the spreader base, interfacial resistance across the thermal interface material (TIM), and convection within the coolant channels while enforcing a pressure-drop constraint. The optimization uses a deterministic continuation method with smooth sigmoid mappings and penalty functions to maintain constraint satisfaction and stable convergence across the design space. The total thermal resistance ($R_{\mathrm{tot}}$) is minimized over spreader conductivities $k_s=400–2200$ W m⁻¹ K⁻¹ (copper to CVD diamond), inlet fluid velocities $U_{\mathrm{in}}=0.5–5.5$ m s⁻¹, maximum pressure drops of 10–50 kPa, and fluid pass counts $N_p\in \{1,2,3\}$. The resulting maps of optimized fin dimensions as functions of $k_s$ provide continuous design charts that clarify how material conductivity, flow rate, and pass configuration collectively determine the geometry, minimizing total thermal resistance, thereby reducing chip temperature rise for a given heat load. Full article

This study presents a method for enriching oil-suspended particles within a rectangular microfluidic channel using acoustic standing waves. A modified Helmholtz equation is solved to establish the acoustic field model, and the equilibrium between acoustic radiation forces and viscous drag is described by combining Gor’kov potential theory with the Stokes drag model. Based on this force balance, the particle motion equation is derived, enabling the determination of the critical particle size necessary for efficient enrichment in oil-filled microchannels. A two-dimensional standing-wave microchannel model is subsequently developed, and the influences of acoustic, fluidic, and particle parameters on particle migration and aggregation are systematically investigated through theoretical analysis and numerical simulations. The results indicate that when the channel dimension and acoustic wavelength satisfy the half-wavelength resonance condition, a stable standing-wave field forms, effectively focusing suspended particles at the acoustic pressure nodes. Enrichment efficiency is found to be strongly dependent on inlet flow velocity, particle diameter, acoustic frequency, temperature, and particle density. Lower flow velocities and larger particle sizes result in higher enrichment efficiencies, with the most uniform and stable pressure distribution achieved when the acoustic frequency matches the resonant channel width. Increases in temperature and particle density enhance the acoustic radiation force, thereby accelerating the aggregation of particles. These findings offer theoretical foundations and practical insights for acoustically assisted online monitoring of wear particles in lubricating oils, contributing to advanced condition assessment and fault diagnosis in mechanical systems. Full article

A carbon nanotube (CNT)-integrated microfluidic electrochemical sensor was developed for sensitive nanoparticle detection using gold nanoparticles (AuNPs) as the model analyte. The device incorporated screen-printed polyethylene terephthalate (PET) electrodes, a polydimethylsiloxane (PDMS) microchannel, and a CNT membrane that simultaneously served as a filtration layer and working electrode. This configuration enhanced analyte trapping, increased the electroactive surface area, and accelerated electron transfer under convective flow. The CNT membrane was fabricated by vacuum filtration and torch-assisted bonding, ensuring strong adhesion without adhesives or plasma treatment. Electrochemical analysis showed that the filter-integrated CNT sensor exhibited an oxidation current of 63 µA compared to 11 µA for the non-filter sensor, representing a fifteen-fold sensitivity enhancement. The detection limit improved from 1.0 × 10⁻³ to 7.5 × 10⁻⁴ mol·L⁻¹ with excellent reproducibility (RSD < 5%) and ∼90% accuracy. These findings validated the filtration-assisted accumulation mechanism and demonstrated the effectiveness of CNT-integrated microfluidic sensors for enhanced nanoparticle detection, while highlighting their potential for future adaptation to biosensing applications. Full article

The combustion diagnostics of rotating detonation engines (RDE) based on excited-state hydroxyl radical (OH*) chemiluminescence imaging is an important method used to characterize combustion flow fields. Overcoming the limitations of imaging devices to achieve nanosecond-scale temporal resolution is crucial for observing the propagation of high-frequency detonation waves. In this work, a nanosecond-scale imaging system with an ultra-high spatiotemporal resolution was designed and constructed. The system employs four near ultraviolet (NUV)-visible ICMOS, equipped with a high-gain, dual-microchannel plate (MCP) architecture fabricated using a new atomic layer deposition (ALD) process. The system has a maximum electronic gain of 10⁷, a minimum integration time of 3 ns, a minimum interval time 4 ns, and an imaging resolution of 1608 × 1104 pixels. Using this system, high-spatiotemporal-resolution visualization experiments were conducted on RDE, fueled by H₂–oxygen-enriched air and NH₃–H₂–oxygen-enriched air. The results enable the observation of the detonation wave structure, the cellular structure, and the propagation velocity. In combination with optical flow analysis, the images reveal vortex structures embedded within the cellular structure. For NH₃-H₂ mixed fuel, the results indicate that detonation wave propagation is more unstable than in H₂ combustion, with a larger bright gray area covering both the detonation wave and the product region. The experimental results demonstrate that high spatiotemporal OH* imaging enables non-contact, full-field measurements, providing valuable data for elucidating RDE combustion mechanisms, guiding model design, and supporting NH₃ combustion applications. Full article

Microfluidics is considered a revolutionary interdisciplinary technology with substantial interest in various biomedical applications. Many non-Newtonian fluids often used in microfluidics systems are notably influenced by the external active fields, such as acoustic, electric, and magnetic fields, leading to changes in rheological behavior. In this study, a numerical investigation is carried out to explore the rheological behavior of non-Newtonian fluids in a T-shaped microfluidics channel integrated with complex micropillar structures under the influence of acoustic, electric, and magnetic fields. For this purpose, COMSOL Multiphysics with laminar flow, pressure acoustic, electric current, and magnetic field physics is used to examine rheological characteristics of non-Newtonian fluids. Three polymer solutions, such as 2000 ppm xanthan gum (XG), 1000 ppm polyethylene oxide (PEO), and 1500 ppm polyacrylamide (PAM), are used as a non-Newtonian fluids with the Carreau–Yasuda fluid model to characterize the shear-thinning behavior. Moreover, numerical simulations are carried out with different input parameters, such as Reynolds numbers (0.1, 1, 10, and 50), acoustic pressure (5 Mpa, 6.5 Mpa, and 8 Mpa), electric voltage (200 V, 250 V, and 300 V), and magnetic flux (0.5 T, 0.7 T, and 0.9 T). The findings reveal that the incorporation of active fields and micropillar structures noticeably impacts fluid rheology. The acoustic field induces higher shear-thinning behavior, decreasing dynamic viscosity from 0.51 Pa·s to 0.34 Pa·s. Similarly, the electric field induces higher shear rates, reducing dynamic viscosities from 0.63 Pa·s to 0.42 Pa·s, while the magnetic field drops the dynamic viscosity from 0.44 Pa·s to 0.29 Pa·s. Additionally, as the Reynolds number increases, the shear rate also rises in the case of electric and magnetic fields, leading to more chaotic flow, while the acoustic field advances more smooth flow patterns and uniform fluid motion within the microchannel. Moreover, a proposed experimental framework is designed to study non-Newtonian fluid mixing in a T-shaped microfluidics channel under external active fields. Initially, the microchannel was fabricated using a high-resolution SLA printer with clear photopolymer resin material. Post-processing involved analyzing particle distribution, mixing quality, fluid rheology, and particle aggregation. Overall, the findings emphasize the significance of considering the fluid rheology in designing and optimizing microfluidics systems under active fields, especially when dealing with complex fluids with non-Newtonian characteristics. Full article

Microchannels can create disturbed flow patterns by altering pressure gradients, shear forces, and flow symmetry, which are essential in the design of microfluidic devices and, hence, blood-contacting devices. The effect of asymmetric stenosis on pressure, wall shear stress, and velocity in rectangular and circular microchannels with same operating conditions was analyzed in this study using three-dimensional (3D) steady laminar computational fluid dynamics (CFD) simulations. Asymmetric flow patterns induced by asymmetric stenosis are of particular importance and remain underexplored, especially in the context of multiple constrictions. This is, to our knowledge, is the first systematic CFD comparison of multiple asymmetric stenoses in circular microchannels directly contrasted with rectangular and single-stenosis cases under identical settings. Several parameters, such as wall shear stress (WSS), pressure, and velocity distributions, were analyzed in various stenotic and non-stenotic geometries. These microchannel models, while not reflecting real blood vessels themselves nor exhibiting wall compliance, pulsatility, or non-Newtonian rheology, replicate important mechanical characteristics of stenosis-mediated flow disturbance. Single and multiple asymmetric stenoses create flow patterns that are similar to those of vascular pathologies. For this reason, these channels should be considered as simplified device-scale models of vascular phenomena as opposed to realistic, in vitro vascular models. The results showed that asymmetric stenosis creates asymmetric velocity peaks and elevated WSS, which are more evident in the case of circular configurations with double asymmetric stenosis. The findings will help design microfluidic devices that mimic unstable flow characteristics that occur in stenotic conditions, and assist in testing clinical devices. In this study, two fabrication-ready microchannel designs under fixed operating conditions (identical inlet velocity and fluid properties) that reflect common microfluidic use were compared. Consequently, all pressure, velocity, and WSS outcomes are interpreted as device-scale responses under fixed velocity, rather than a fundamental isolation of cross-section shape, which would require matched hydraulic diameters or flow rates. This study is explicitly device-oriented, representing a fixed operating point rather than a strict geometric isolation. Accordingly, the results are also expressed with dimensionless loss coefficients (Ktot and Klocal) to enable scale-independent, device-level comparison. Full article

Red blood cell (RBC) deformability is a critical biophysical property that enables effective passage of RBCs through microvasculature and ensures proper oxygen delivery. Impairment of this property is associated with various pathological conditions, including type 2 diabetes mellitus (T2DM). In this study, we developed an automated microfluidic platform for high-throughput and real-time assessment of RBC deformability under controlled flow conditions. The device features a structured microchannel design and integrated imaging to quantify individual cell deformation responses. Comparative analyses of RBCs from healthy individuals and T2DM patients revealed significant reductions in deformability in the diabetic group. In vivo validation using a diabetic mouse model further confirmed the progressive decline in RBC deformability under chronic hyperglycemia. This microfluidic approach provides a robust and efficient tool for characterizing RBC mechanical properties, offering potential for disease monitoring and clinical diagnostic applications. Full article

The separable heat pipe, with its highly efficient heat transfer and flexible layout features, has become an innovative solution to the heat dissipation problem of batteries, especially suitable for the directional heat dissipation requirements of high-energy-density battery packs. However, most of the number–value models currently studied examine the flow of refrigerant working medium within the pump as an isentropic or isothermal process and are unable to effectively analyze the heat transfer characteristics of different internal regions. Based on the laws of energy conservation, momentum conservation, and mass conservation, this study establishes a steady-state mathematical model of the pump-driven microchannel-separated heat pipe. The influence of factors—such as the phase state change in the working medium inside the heat exchanger, the heat transfer flow mechanism, the liquid filling rate, the temperature difference, as well as the structural parameters of the microchannel heat exchanger on the steady-state heat transfer and flow performance of the pump-driven microchannel-separated heat pipe—were analyzed. It was found that the influence of liquid filling ratio on heat transfer quantity is reflected in the ratio of change in the sensible heat transfer and latent heat transfer. The sensible heat transfer ratio is higher when the liquid filling is too low or too high, and the two-phase heat transfer is higher when the liquid filling ratio is in the optimal range; the maximum heat transfer quantity can reach 3.79 KW. The decrease in heat transfer coefficient with tube length in the single-phase region is due to temperature and inlet effect, and the decrease in heat transfer coefficient in the two-phase region is due to the change in flow pattern and heat transfer mechanism. This technology has the advantages of long-distance heat transfer, which can adapt to the distributed heat dissipation needs of large-energy-storage power plants and help reduce the overall lifecycle cost. Full article

Microfluidic impedance cytometry enables label-free and real-time single-cell analysis by detecting changes in electrical impedance as cells traverse microchannels. Electrode configuration plays a critical role in determining detection sensitivity, signal quality, and spatial resolution. In this study, finite element simulations were conducted to model the impedance response of mammalian red blood cells under various electrode designs, including coplanar, parallel, tilted, and parabolic configurations, as well as electrode layouts coupled with flow velocity. A multiphysics simulation model was established to analyze the effects of geometric parameters on electric field distribution and impedance response. The results demonstrate that optimized electrode arrangements significantly enhance detection performance and enable multi-parameter analysis. Furthermore, the influence of flow dynamics and dielectric properties on impedance signals is explored. These findings provide both theoretical and experimental guidance for the development of high-efficiency, integrated impedance cytometry platforms, contributing to the advancement of microfluidic systems in biomedical diagnostics and single-cell characterization. Full article

This study numerically investigates the growth and dynamics of a single vapor bubble in a rectangular microchannel under subcooled and saturated inlet conditions using the phase-field method coupled with the Lee phase-change model. Results demonstrate that subcooled flow induces early bubble nucleation, pronounced lateral expansion along the heated wall, and prolonged bubble-wall contact due to stronger condensation at the interface and thinner microlayer formation. Enhanced recirculating vortices and steeper thermal gradients promote vigorous evaporation and increased local heat flux, resulting in faster downstream bubble propagation driven by significant axial pressure gradients. Analysis of temperature gradient and heat flux profiles confirms that subcooled conditions produce higher wall heat flux and more frequent peaks in evaporative flux compared to the saturated case, indicating intensified phase-change activity and thermal transport. Conversely, saturated conditions produce more spherical bubbles with dominant vertical growth, weaker condensation, and symmetrical thermal and pressure fields, leading to slower growth and delayed detachment near the nucleation site. These findings highlight the critical influence of inlet subcooling on bubble morphology, flow structures, heat transfer, and pressure distribution, underscoring the thermal management advantages of subcooled boiling in microchannel applications. Full article

The role of wall roughness in heat and mass transfer for fully developed viscous flows in square microchannels is investigated here. Since the roughness, which is the key geometrical feature to be investigated, introduces high velocity gradients at the wall, the effect of the viscous dissipation is considered. A fully developed flow in the forced convection regime is assumed. This assumption allows the two-dimensional treatment of the problem; thus, the velocity and temperature fields are simulated on the microchannel cross-section. The boundary roughness is modeled by randomly throwing points around the nominal square cross-section perimeter and by connecting those points to generate a simple polygon. This modification of the nominal square shape of the cross-section influences the velocity and temperature fields, which are computed by employing a finite element method solver. The heat and mass transfer is studied by calculating the Nusselt and the Poiseuille numbers as a function of roughness amplitude at the boundary. Each Nusselt and Poiseuille number is obtained by employing an averaging procedure over a sample of a thousand cases. Full article

Compact and efficient absorption refrigeration systems can effectively utilize waste heat and renewable energy when operated in a boiling-desorption mode, which maximizes the desorption rate. Hydrophobic membranes play a critical role in microchannel membrane-based generators; however, limited research has addressed bubble cross-membrane removal dynamics under boiling-desorption conditions, particularly the influence of membrane hydrophobicity. In this study, a two-phase flow bubble-removal model was developed to accurately represent boiling-desorption behavior. Numerical simulations were performed to investigate the effects of membrane hydrophobicity and heating power on bubble dynamics, wall temperature, venting rate, and channel pressure drop. Results show that bubble venting proceeds through four stages: nucleation and growth, liquid-film rupture with deformation, lateral spreading, and sustained vapor removal. Hydrophobicity effects become most significant from the third stage onwards. Increased hydrophobicity reduces wall temperature, with greater reductions at higher heat fluxes, and enhances venting performance by increasing total vapor removal and reducing removal time. Channel pressure fluctuations comprise high-frequency components from bubble growth and low-frequency components from venting-induced flow interruptions, with relative contributions dependent on hydrophobicity and heat flux. These findings provide new insights into bubble-removal mechanisms and offer guidance for the design and optimization of high-performance microchannel membrane-based generators. Full article

The unsteady and discontinuous liquid flow in the microchannel affects the efficiency of sample mixing, molecular detection, target acquisition, and biochemical reaction. In this work, an active method of reducing the flow pulsation in the microchannel of a pneumatic microfluidic chip is proposed by using an on-chip membrane microvalve as a valve chamber damping hole or a valve chamber accumulator. The structure, working principle, and multi-physical model of the reducing element of reducing the flow pulsation in a microchannel are presented. When the flow pulsation in the microchannel is sinusoidal, square wave, or pulse, the simulation effect of flow pulsation reduction is given when the membrane valve has different permutations and combinations. The experimental results show that the inlet flow of the reducing element is a square wave pulsation with an amplitude of 0.1 mL/s and a period of 2 s, the outlet flow of the reducing element is assisted by 0.017 and the fluctuation frequency is accompanied by a decrease. The test data and simulation results verify the rationality of the flow reduction element in the membrane valve microchannel, the correctness of the theoretical model, and the practicability of the specific application, which provides a higher precision automatic control technology for the microfluidic chip with high integration and complex reaction function. Full article

The fabrication of microfluidic components using low-cost Fused Deposition Modeling (FDM) presents an attractive alternative to conventional manufacturing methods, yet achieving microscale dimensional accuracy remains a significant challenge. This study investigates the influence of five key FDM parameters (nozzle temperature, bed temperature, printing speed, flow rate, and infill overlap) on the dimensional accuracy of microchannels printed with PETG and TPU filaments. A Taguchi L27 orthogonal array was employed to systematically evaluate the effects of these parameters on width and depth deviations across sub-millimeter microchannel geometries. Results show that for PETG, optimal dimensional fidelity was achieved at 240 °C nozzle temperature, 70 °C bed temperature, 30 mm/s speed, 100% flow rate, and 15% overlap, enabling reliable channel widths down to 100 µm. TPU exhibited greater variability due to its elasticity, with optimal settings found at 220 °C, 60 °C bed temperature, 30 mm/s, 100% flow rate, and 25% overlap. Signal-to-noise ratio and ANOVA analyses revealed flow rate and printing speed as dominant factors for both materials. The findings provide a reproducible optimization framework for microscale FDM fabrication and highlight material-specific process sensitivities critical to functional microfluidic device performance. Full article

The critical heat flux (CHF) of minichannel heat sinks is crucial, as it helps prevent thermal safety incidents and equipment failure. However, the underlying mechanisms of CHF in minichannels remain poorly understood, and existing CHF prediction models require further refinement. This study systematically investigates the characteristics and influencing factors of critical heat flux (CHF) in rectangular minichannels through combined experimental and theoretical approaches. Experiments were conducted using microchannels with hydraulic diameters ranging from 0.5 to 2.0 mm, with ethanol employed as the working fluid. Key parameters-including mass flux, channel geometry, system pressure, and inlet subcooling-were analyzed to assess their influence on CHF. Results indicate that CHF increases with mass flux; however, the increase rate diminishes under higher mass flux. Larger channel dimensions significantly enhance CHF by delaying liquid film dryout. System pressure further improves CHF by reducing bubble detachment frequency and promoting flow stability. Increased inlet subcooling enhances CHF by delaying the onset of nucleate boiling and improving convective heat transfer. Four classical CHF prediction models were evaluated, revealing significant overprediction-up to 148.69% mean absolute error (MAE)-particularly for channels with hydraulic diameters below 1.0 mm. An ANN deep learning model was developed, achieving a reduced MAE of 8.93%, with 93% of predictions falling within ±15% error. This study offers valuable insights and a robust predictive model for optimizing microchannel heat sink performance in high heat flux applications. Full article