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16 pages, 3955 KiB  
Article
Enhancement of In-Store Product Replenishment Flow and Introduction of Pull Approach in a Food Retail Chain
by Elisa Vieira, Larissa Tomaz, José Leitão, João Fernandes and José Dinis-Carvalho
Logistics 2025, 9(2), 61; https://doi.org/10.3390/logistics9020061 - 16 May 2025
Viewed by 1025
Abstract
Background: Due to the highly competitive nature of the retail sector, companies need to improve their operational efficiency. This study focuses on the application of the concepts of Lean production in the process of replenishing products on the shelves of the shops [...] Read more.
Background: Due to the highly competitive nature of the retail sector, companies need to improve their operational efficiency. This study focuses on the application of the concepts of Lean production in the process of replenishing products on the shelves of the shops of one of the largest food retail chains in Portugal. Methods: This study aims to apply a transition from a “push” to a “pull” approach, based on real-time consumption. During a 5-day test, the impacts of implementing Lean principles and ergonomic trolleys in the process were investigated. Results: The test led to improved efficiency in product replenishment by eliminating pallets and reducing unfavourable product handling from the initial process. The implementation of a replenishment system in this manner allowed a reduced labour requirements from 28.4 to 19.2 man-hours per day and, the elimination of unnecessary handling and increase of product availability were reflected in gains on operational time and in replenishment time. Conclusions: This study provides empirical evidence for the effectiveness of Lean pull systems in retail replenishment, demonstrating a 32% reduction in labour hours. Full article
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8 pages, 2905 KiB  
Case Report
Air Travel-Triggered Tension Pneumocephalus Caused by a Frontal Sinus Osteoma: Case Report
by Aleksandar Djurdjevic, Milan Lepic, Jovana Djurdjevic, Svetozar Stankovic and Goran Pavlicevic
Reports 2025, 8(1), 10; https://doi.org/10.3390/reports8010010 - 18 Jan 2025
Viewed by 1025
Abstract
Background and Clinical Significance: Pneumocephalus, an accumulation of air within the cranial cavity, typically arises from trauma or iatrogenic causes. However, spontaneous occurrences of this are rare and linked to various pathologies affecting the paranasal sinuses, the ear, or the skull base. [...] Read more.
Background and Clinical Significance: Pneumocephalus, an accumulation of air within the cranial cavity, typically arises from trauma or iatrogenic causes. However, spontaneous occurrences of this are rare and linked to various pathologies affecting the paranasal sinuses, the ear, or the skull base. The impact of air travel on individuals with pneumocephalus remains uncertain despite ongoing research. We report a unique case of spontaneous tension pneumocephalus attributed to a frontal sinus osteoma during air travel. Case Presentation: A 55-year-old man presented with headache and dizziness, initiated during a nine-hour international flight two weeks prior. The symptoms abated after landing but recurred on his return flight, accompanied by confusion the following day. A neurological examination revealed no deficits. CT and MRI scans indicated the presence of intraparenchymal air collection in the right frontal lobe, attributed to a frontal sinus osteoma causing a dural tear. Surgical intervention included duroplasty and osteoma removal, with postoperative recovery free of complications. Conclusions: Frontal sinus osteoma-induced tension pneumocephalus is exceedingly rare, with only limited cases reported in the literature. This case shows that air travel may exacerbate intracranial gas dynamics that lead to development of tension pneumocephalus with a potentially fatal outcome for patients. Full article
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22 pages, 23478 KiB  
Article
Target Detection and Characterization of Multi-Platform Remote Sensing Data
by Koushikey Chhapariya, Emmett Ientilucci, Krishna Mohan Buddhiraju and Anil Kumar
Remote Sens. 2024, 16(24), 4729; https://doi.org/10.3390/rs16244729 - 18 Dec 2024
Cited by 1 | Viewed by 1581
Abstract
Detecting targets in remote sensing imagery, particularly when identifying sparsely distributed materials, is crucial for applications such as defense, mineral exploration, agriculture, and environmental monitoring. The effectiveness of detection and the precision of the results are influenced by several factors, including sensor configurations, [...] Read more.
Detecting targets in remote sensing imagery, particularly when identifying sparsely distributed materials, is crucial for applications such as defense, mineral exploration, agriculture, and environmental monitoring. The effectiveness of detection and the precision of the results are influenced by several factors, including sensor configurations, platform properties, interactions between targets and their background, and the spectral contrast of the targets. Environmental factors, such as atmospheric conditions, also play a significant role. Conventionally, target detection in remote sensing has relied on statistical methods that typically assume a linear process for image formation. However, to enhance detection performance, it is critical to account for the geometric and spectral variabilities across multiple imaging platforms. In this research, we conducted a comprehensive target detection experiment using a unique benchmark multi-platform hyperspectral dataset, where man-made targets were deployed on various surface backgrounds. Data were collected using a hand-held spectroradiometer, UAV-mounted hyperspectral sensors, and airborne platforms, all within a half-hour time window. Multi-spectral space-based sensors (i.e., Worldview and Landsat) also flew over the scene and collected data. The experiment took place on 23 July 2021, at the Rochester Institute of Technology’s Tait Preserve in Penfield, NY, USA. We validated the detection outcomes through receiver operating characteristic (ROC) curves and spectral similarity metrics across various detection algorithms and imaging platforms. This multi-platform analysis provides critical insights into the challenges of hyperspectral target detection in complex, real-world landscapes, demonstrating the influence of platform variability on detection performance and the necessity for robust algorithmic approaches in multi-source data integration. Full article
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19 pages, 13726 KiB  
Article
Thermal Comfort and Green Spaces: The Role of Temperature-Regulating Elements in Neighborhood Parks
by Nurcan Akarsu Varşak and Elvan Ender Altay
Sustainability 2024, 16(22), 9801; https://doi.org/10.3390/su16229801 - 10 Nov 2024
Cited by 1 | Viewed by 1935
Abstract
According to current studies, the thermal effects of global warming will affect urban areas more intensely. In the face of this situation, strategies for the improvement and management of urban green spaces are becoming increasingly important in sustainable landscape design. These strategies promote [...] Read more.
According to current studies, the thermal effects of global warming will affect urban areas more intensely. In the face of this situation, strategies for the improvement and management of urban green spaces are becoming increasingly important in sustainable landscape design. These strategies promote social sustainability by positively affecting individuals’ physical and psychological well-being, taking into consideration ecological sustainability. Projections regarding global warming emphasize that the density of hardscapes and green spaces, the selection of plant species, and the distribution of plants considered within the scope of this study should be taken into account. This research was conducted in the Görükle neighborhood of Bursa, focusing on the role of temperature-regulating elements in 14 neighborhood parks. Systematic temperature measurements were carried out in the research area on the 10th, 20th, and 30th of July and August, specifically between 12:00 and 13:00, during peak temperature hours. The presence of parks that are close to each other and relatively far away from each other in the study area was seen as advantageous to filter the effects of plant differences in similar conditions. Furthermore, evaluating these various factors together highlights the multifaceted nature of thermal comfort. Designated temperature measurement points included three points (hard surfaces and hard surfaces surrounded by vegetation and planted green spaces) in each park. An analysis utilizing SPSS and the RayMan program revealed that parks with a softscape to hardscape ratio of approximately two to one experienced temperature reductions of 2.5 to 3 °C. Furthermore, the findings indicate that coniferous trees have a more significant impact on thermal comfort compared to deciduous trees. The significant differences identified in this study underscore essential considerations for urban design processes aimed at achieving sustainability. Full article
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10 pages, 9136 KiB  
Case Report
Post-Exercise Syncope in a Previously Healthy 67-Year-Old Man: The Bezold–Jarisch Reflex and the Role of Autonomic Nervous System Dysfunction
by Livija Sušić, Marina Vidosavljević, Marko Burić, Antonio Burić and Lana Maričić
Hearts 2024, 5(4), 472-481; https://doi.org/10.3390/hearts5040034 - 26 Oct 2024
Viewed by 1586
Abstract
A 67-year-old man started treatment due to frequent asymptomatic premature ventricular complexes (PVCs) accidentally being registered during a preventive examination by a specialist, because of which he was referred to cardiologist. During the initial 24-hour (h) ECG monitoring, 4.5% PVCs and one episode [...] Read more.
A 67-year-old man started treatment due to frequent asymptomatic premature ventricular complexes (PVCs) accidentally being registered during a preventive examination by a specialist, because of which he was referred to cardiologist. During the initial 24-hour (h) ECG monitoring, 4.5% PVCs and one episode of asymptomatic non-sustained ventricular tachycardia (NSVT) with three PVCs in row, at a frequency of 150 beats per minute (bpm), were detected. After the introduction of beta blockers into therapy, a lower number of PVCs, without NSVT, were recorded in the control 24 h Holter ECG, while transthoracic echocardiography (TTE) showed normal left ventricular (LV) systolic function without cardiomyopathy. So, an exercise test was indicated, and it was interrupted in the third minute at 120 beats per minute (bpm) due to fatigue and pain in the hips, without malignant arrhythmias, angina or dyspneic complaints. During the rest period, a significant inferolateral depression of the ST junction was observed, which recovered in the ninth minute. Immediately after the ECG monitoring stopped, the patient lost consciousness; his pulse was not palpable, but breathing was audible, so cardiac massage was started. After he had regained consciousness, the ECG showed alternating sinus and junctional rhythm with the lowest frequency of 33 bpm, which was accompanied by marked hypotension (80/50 mmHg). The patient was immediately hospitalized; coronary angiography and repeated TTE were completely normal, while continuous ECG monitoring did not confirm malignant rhythm disorders or asystole. It was concluded that it was vasovagal syncope (VVS), most likely caused by the Bezold–Jarisch reflex (BJR). Full article
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66 pages, 1675 KiB  
Article
Comprehensive Risk Analysis of Emergency Medical Response Systems in Serbian Healthcare: Assessing Systemic Vulnerabilities in Disaster Preparedness and Response
by Vladimir M. Cvetković, Jasmina Tanasić, Renate Renner, Vanja Rokvić and Hatiža Beriša
Healthcare 2024, 12(19), 1962; https://doi.org/10.3390/healthcare12191962 - 1 Oct 2024
Cited by 4 | Viewed by 3705
Abstract
Background/Objectives: Emergency Medical Response Systems (EMRSs) play a vital role in delivering medical aid during natural and man-made disasters. This quantitative research delves into the analysis of risk and effectiveness within Serbia’s Emergency Medical Services (EMS), with a special emphasis on how work [...] Read more.
Background/Objectives: Emergency Medical Response Systems (EMRSs) play a vital role in delivering medical aid during natural and man-made disasters. This quantitative research delves into the analysis of risk and effectiveness within Serbia’s Emergency Medical Services (EMS), with a special emphasis on how work organization, resource distribution, and preparedness for mass casualty events contribute to overall disaster preparedness. Methods: The study was conducted using a questionnaire consisting of 7 sections and a total of 88 variables, distributed to and collected from 172 healthcare institutions (Public Health Centers and Hospitals). Statistical methods, including Pearson’s correlation, multivariate regression analysis, and chi-square tests, were rigorously applied to analyze and interpret the data. Results: The results from the multivariate regression analysis revealed that the organization of working hours (β = 0.035) and shift work (β = 0.042) were significant predictors of EMS organization, explaining 1.9% of the variance (R2 = 0.019). Furthermore, shift work (β = −0.045) and working hours (β = −0.037) accounted for 2.0% of the variance in the number of EMS points performed (R2 = 0.020). Also, the availability of ambulance vehicles (β = 0.075) and financial resources (β = 0.033) explained 4.1% of the variance in mass casualty preparedness (R2 = 0.041). When it comes to service area coverage, the regression results suggest that none of the predictors were statistically significant. Based on Pearson’s correlation results, there is a statistically significant correlation between the EMS organization and several key variables such as the number of EMS doctors (p = 0.000), emergency medicine specialists (p = 0.000), etc. Moreover, the Chi-square test results reveal statistically significant correlations between EMS organization and how EMS activities are conducted (p = 0.001), the number of activity locations (p = 0.005), and the structure of working hours (p = 0.001). Conclusions: Additionally, the results underscore the necessity for increased financial support, standardized protocols, and enhanced intersectoral collaboration to strengthen Serbia’s EMRS and improve overall disaster response effectiveness. Based on these findings, a clear roadmap is provided for policymakers, healthcare administrators, and EMS personnel to prioritize strategic interventions and build a robust emergency medical response system. Full article
(This article belongs to the Section Healthcare Quality and Patient Safety)
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12 pages, 1634 KiB  
Case Report
Clinical, Psychiatric and Medicolegal Issues in Non-Fatal Strangulation: A Case Report
by Lina De Paola, Valeria Piersanti, Dalila Tripi, Enrico Marinelli, Simona Zaami and Gabriele Napoletano
Forensic Sci. 2024, 4(4), 475-486; https://doi.org/10.3390/forensicsci4040031 - 24 Sep 2024
Viewed by 2598
Abstract
Introduction: on-fatal strangulation (NFS) is a dangerous mechanism that can produce injuries with varying levels of severity. NFS-related injuries can range from low severity, such as simple contusions, to very severe, with convulsions and major forms of impairment. It is often difficult to [...] Read more.
Introduction: on-fatal strangulation (NFS) is a dangerous mechanism that can produce injuries with varying levels of severity. NFS-related injuries can range from low severity, such as simple contusions, to very severe, with convulsions and major forms of impairment. It is often difficult to gauge the severity of injuries from external and initial manifestations alone; it is therefore necessary to assess the possibility of misdiagnosed injuries or subsequent manifestations. Case report: In this study, we describe the case of a 71-year-old man with several injuries, mainly in the craniofacial region, following an assault by his flatmate. Not only did the subject suffer a concussive head injury and a fracture of the zygomatic bone, but he was also subjected to NFS. The patient was examined three times, and the third examination was carried out directly by us 40 days after the assault. Discussion: We concluded that NFS-related injuries are not always clearly visible and recognized after some time. It would therefore be necessary to standardize the clinical investigation procedure in suspected or confirmed cases of NFS. Conclusion: Clinical investigation should be done from the first hours after the injury event, with the help of forensic experts, with the use of dedicated instrumentation and the acquisition of photographic images, all carried out in a systematic manner for use in court, and a search performed for after-effects that cannot be identified by other methods. Psychological evaluation should also be considered as part of the broader assessment process as victims of NFS often experience significant psychological trauma. Full article
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28 pages, 1806 KiB  
Article
Dynamic Workload Management System in the Public Sector
by Konstantinos C. Giotopoulos, Dimitrios Michalopoulos, Gerasimos Vonitsanos, Dimitris Papadopoulos, Ioanna Giannoukou and Spyros Sioutas
Information 2024, 15(6), 335; https://doi.org/10.3390/info15060335 - 6 Jun 2024
Cited by 6 | Viewed by 2839
Abstract
Workload management is a cornerstone of contemporary human resource management with widespread applications in private and public sectors. The challenges in human resource management are particularly pronounced within the public sector: particularly in task allocation. The absence of a standardized workload distribution method [...] Read more.
Workload management is a cornerstone of contemporary human resource management with widespread applications in private and public sectors. The challenges in human resource management are particularly pronounced within the public sector: particularly in task allocation. The absence of a standardized workload distribution method presents a significant challenge and results in unnecessary costs in terms of man-hours and financial resources expended on surplus human resource utilization. In the current research, we analyze how to deal with the “race condition” above and propose a dynamic workload management model based on the response time required to implement each task. Our model is trained and tested using comprehensive employee data comprising 450 records for training, 100 records for testing, and 88 records for validation. Approximately 11% of the initial data are deemed either inaccurate or invalid. The deployment of the ANFIS algorithm provides a quantified capability for each employee to handle tasks in the public sector. The proposed idea is deployed in a virtualized platform where each employee is implemented as an independent node with specific capabilities. An upper limit of work acceptance is proposed based on a documented study and laws that suggest work time frames in each public body, ensuring that no employee reaches the saturation level of exhaustion. In addition, a variant of the “slow start” model is incorporated as a hybrid congestion control mechanism with exceptional outcomes, offering a gradual execution window for each node under test and providing a smooth and controlled start-up phase for new connections. The ultimate goal is to identify and outline the entire structure of the Greek public sector along with the capabilities of its employees, thereby determining the organization’s executive capacity. Full article
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10 pages, 2133 KiB  
Article
Detection of Gene Doping Using Dried Blood Spots from a Mouse Model with rAAV9 Vector-Mediated Human Erythropoietin Expression as a Pilot Study
by Norihiro Otani, Yasuharu Kanki, Kieu D. M. Nguyen and Takehito Sugasawa
Analytica 2024, 5(2), 263-272; https://doi.org/10.3390/analytica5020017 - 4 Jun 2024
Cited by 2 | Viewed by 2253
Abstract
Rapid advancements in gene technology have raised concerns regarding the potential abuse of techniques, such as gene doping, for enhancing athletic performance. To identify this possibility, a reliable procedure for detecting doping genes is required. Although detection methods for doping genes have been [...] Read more.
Rapid advancements in gene technology have raised concerns regarding the potential abuse of techniques, such as gene doping, for enhancing athletic performance. To identify this possibility, a reliable procedure for detecting doping genes is required. Although detection methods for doping genes have been created, there are still areas for further improvement. One significant challenge is the high storage and transport costs of the test samples. For this issue, the dried blood spot (DBS) method can be a cost-effective solution. This study aimed to assess the practicality of incorporating DBSs into the gene doping detection process as a pilot study. Whole-blood samples were initially collected from mice engineered to express human erythropoietin from the rAAV vector. Then, the blood was placed in filter papers and left to dry at room temperature for five hours to form DBSs. These DBSs were subsequently preserved in sealed plastic bags at room temperature. After the extraction of DNA, DBSs were formed, and TaqMan-qPCR was utilized to detect the presence of rAAV vector-derived DNA. The finding confirmed that doping gene-specific fragments were successfully detected in DBSs. This outcome suggests that the DBS method is an effective approach to be considered when developing a comprehensive protocol for gene doping detection. Full article
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18 pages, 2981 KiB  
Article
A Study on the Man-Hour Prediction in Structural Steel Fabrication
by Zhangliang Wei, Zhigang Li, Renzhong Niu, Peilin Jin and Zipeng Yu
Processes 2024, 12(6), 1068; https://doi.org/10.3390/pr12061068 - 23 May 2024
Cited by 1 | Viewed by 2414
Abstract
Longitudinal cutting is the most common process in steel structure manufacturing, and the man-hours of the process provide an important basis for enterprises to generate production schedules. However, currently, the man-hours in factories are mainly estimated by experts, and the accuracy of this [...] Read more.
Longitudinal cutting is the most common process in steel structure manufacturing, and the man-hours of the process provide an important basis for enterprises to generate production schedules. However, currently, the man-hours in factories are mainly estimated by experts, and the accuracy of this method is relatively low. In this study, we propose a system that predicts man-hours with history data in the manufacturing process and that can be applied in practical structural steel fabrication. The system addresses the data inconsistency problem by one-hot encoding and data normalization techniques, Pearson correlation coefficient for feature selection, and the Random Forest Regression (RFR) for prediction. Compared with the other three Machine-Learning (ML) algorithms, the Random Forest algorithm has the best performance. The results demonstrate that the proposed system outperforms the conventional approach and has better forecast accuracy so it is suitable for man-hours prediction. Full article
(This article belongs to the Section Materials Processes)
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17 pages, 5550 KiB  
Article
Synthetic Dataset Generation Using Photo-Realistic Simulation with Varied Time and Weather Axes
by Thomas Lee, Susan Mckeever and Jane Courtney
Electronics 2024, 13(8), 1516; https://doi.org/10.3390/electronics13081516 - 17 Apr 2024
Viewed by 2086
Abstract
To facilitate the integration of autonomous unmanned air vehicles (UAVs) in day-to-day life, it is imperative that safe navigation can be demonstrated in all relevant scenarios. For UAVs using a navigational protocol driven by artificial neural networks, training and testing data from multiple [...] Read more.
To facilitate the integration of autonomous unmanned air vehicles (UAVs) in day-to-day life, it is imperative that safe navigation can be demonstrated in all relevant scenarios. For UAVs using a navigational protocol driven by artificial neural networks, training and testing data from multiple environmental contexts are needed to ensure that bias is minimised. The reduction in predictive capacity when faced with unfamiliar data is a common weak point in trained networks, which worsens the further the input data deviates from the training data. However, training for multiple environmental variables dramatically increases the man-hours required for data collection and validation. In this work, a potential solution to this data availability issue is presented through the generation and evaluation of photo-realistic image datasets from a simulation of 3D-scanned physical spaces which are theoretically linked in a digital twin (DT) configuration. This simulation is then used to generate environmentally varied iterations of the target object in that physical space by two contextual variables (weather and daylight). This results in an expanded dataset of bicycles that contains weather and time-varied components of the same images which are then evaluated using a generic build of the YoloV3 object detection network; the response is then compared to two real image (night and day) datasets as a baseline. The results reveal that the network response remained consistent across the temporal axis, maintaining a measured domain shift of approximately 23% between the two baselines. Full article
(This article belongs to the Special Issue Emerging Technologies in Digital Twins)
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23 pages, 5073 KiB  
Article
Prediction of Ship Painting Man-Hours Based on Selective Ensemble Learning
by Henan Bu, Zikang Ge, Xianpeng Zhu, Teng Yang and Honggen Zhou
Coatings 2024, 14(3), 318; https://doi.org/10.3390/coatings14030318 - 6 Mar 2024
Cited by 4 | Viewed by 1768
Abstract
The precise prediction of painting man-hours is significant to ensure the efficient scheduling of shipyard production and maintain a stable production pace, which directly impacts shipbuilding cycles and costs. However, traditional forecasting methods suffer from issues such as low efficiency and poor accuracy. [...] Read more.
The precise prediction of painting man-hours is significant to ensure the efficient scheduling of shipyard production and maintain a stable production pace, which directly impacts shipbuilding cycles and costs. However, traditional forecasting methods suffer from issues such as low efficiency and poor accuracy. To solve this problem, this paper proposes a selective integrated learning model (ISA-SE) based on an improved simulated annealing algorithm to predict ship painting man-hours. Firstly, the improved particle swarm optimization (MPSO) algorithm and data grouping techniques are employed to achieve the optimal selection and hyperparameter optimization of base learners, constructing a candidate set of base learners. Subsequently, the simulated annealing algorithm is improved by adding random perturbations and using a parallel perturbation search mechanism to enhance the algorithm’s global search capability. Finally, an optimal set of base learners is composed of the candidate set utilizing the ISA-SE model, and a heterogeneous ensemble learning model is constructed with the optimal set of base learners to achieve the precise prediction of ship painting man-hours. The results indicate that the proposed ISA-SE model demonstrates improvements in accuracy, mean absolute error, and root mean square error compared to other models, validating the effectiveness and robustness of ISA-SE in predicting ship painting man-hours. Full article
(This article belongs to the Special Issue The Present Status of Thermally Sprayed Composite Coatings)
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16 pages, 2622 KiB  
Article
Model for Supporting Construction Workforce Planning Based on the Theory of Fuzzy Sets
by Edyta Plebankiewicz and Patrycja Karcińska
Appl. Sci. 2024, 14(4), 1655; https://doi.org/10.3390/app14041655 - 19 Feb 2024
Cited by 2 | Viewed by 1639
Abstract
The paper presents a model that aims to support the construction contractor in the process of construction workforce planning by verifying initial assumptions about the planned number of man-hours, determined using a widely available and widely used method. The construction of the mathematical [...] Read more.
The paper presents a model that aims to support the construction contractor in the process of construction workforce planning by verifying initial assumptions about the planned number of man-hours, determined using a widely available and widely used method. The construction of the mathematical labour planning model of was based on the fuzzy sets theory. As a result of the operation of the model, four detailed coefficients are obtained, which, after applying the weights of normalized groups of factors, allow to determine the overall result of the model. The model, by verifying the planned number of man-hours, directly influences the employment planning process at a construction site and also supports the scheduling of the overall progress of the works, making it assumedly closer to reality in terms of the involvement of employees as well as the execution time of the construction works. Full article
(This article belongs to the Special Issue Application of Fuzzy Sets in Civil Engineering)
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30 pages, 10320 KiB  
Article
Effect of Street Asymmetry, Albedo, and Shading on Pedestrian Outdoor Thermal Comfort in Hot Desert Climates
by Hakima Necira, Mohamed Elhadi Matallah, Soumia Bouzaher, Waqas Ahmed Mahar and Atef Ahriz
Sustainability 2024, 16(3), 1291; https://doi.org/10.3390/su16031291 - 2 Feb 2024
Cited by 8 | Viewed by 2943
Abstract
Improving urban walkability in the face of climate change is a critical challenge for urban designers. Street design strategies can mitigate heat stress and enhance pedestrian livability. Most previous studies conducted in hot climates recommend adopting deep canyons to improve summer conditions, overlooking [...] Read more.
Improving urban walkability in the face of climate change is a critical challenge for urban designers. Street design strategies can mitigate heat stress and enhance pedestrian livability. Most previous studies conducted in hot climates recommend adopting deep canyons to improve summer conditions, overlooking the potential improvement of wide streets as essential structural elements of the urban fabric. This study was conducted in Biskra city, southern Algeria, where several mitigation strategies were applied to ‘Emir Abdelkader Boulevard’, as the main structural street inside the city, to create an optimal street model for arid climates. Five scenarios were developed based on three criteria: (Sc1) asymmetric profile northeast side (NES) > southwest side (SWS); (Sc2) asymmetric profile SWS > NES; (Sc3) cool paving; (Sc4) horizontal shading; and(Sc5) shading with a linear tree arrangement. ENVI-met software version 5.1.1 and the RayMan model were used to estimate the local climate conditions and outdoor thermal comfort levels based on the physiological equivalent temperature (PET). All scenarios reduced PET values across the street, with optimal reductions of −2.0 °C, −3.1 °C, −1.3 °C, −1.7 °C, and −1.2 °C in Sc1, Sc2, Sc3, Sc4, and Sc5, respectively. Concerning pedestrian areas, the optimal results durations were at the southwest side below the arcades’ sidewalks during peak hours: Sc2, Sc3, Sc4, Sc5 (2.2 °C–3 H, 2.3 °C–3 H, 2.4 °C–3 H, 2.5 °C–2 H). Sc1 performed best during daytime hours on the northeast side. The utilizing of these results can strongly help urban planners and landscape architects in creating climate-responsive streets that enhance citizens’ quality of life. Full article
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9 pages, 262 KiB  
Case Report
Biodetoxification Using Intravenous Lipid Emulsion, a Rescue Therapy in Life-Threatening Quetiapine and Venlafaxine Poisoning: A Case Report
by Cristian Cobilinschi, Liliana Mirea, Cosmin-Andrei Andrei, Raluca Ungureanu, Ana-Maria Cotae, Oana Avram, Sebastian Isac, Ioana Marina Grințescu and Radu Țincu
Toxics 2023, 11(11), 917; https://doi.org/10.3390/toxics11110917 - 9 Nov 2023
Cited by 8 | Viewed by 2707
Abstract
The administration of intravenous lipid emulsion (ILE) is a proven antidote used to reverse local anesthetic-related systemic toxicity. Although the capacity of ILE to generate blood tissue partitioning of lipophilic drugs has been previously demonstrated, a clear recommendation for its use as an [...] Read more.
The administration of intravenous lipid emulsion (ILE) is a proven antidote used to reverse local anesthetic-related systemic toxicity. Although the capacity of ILE to generate blood tissue partitioning of lipophilic drugs has been previously demonstrated, a clear recommendation for its use as an antidote for other lipophilic drugs is still under debate. Venlafaxine (an antidepressant acting as a serotonin–norepinephrine reuptake inhibitor (SNRI)) and quetiapine (a second-generation atypical antipsychotic) are widely used in the treatment of psychotic disorders. Both are lipophilic drugs known to induce cardiotoxicity and central nervous depression. We report the case of a 33-year-old man with a medical history of schizoaffective disorder who was admitted to the emergency department (ED) after having been found unconscious due to a voluntary ingestion of 12 g of quetiapine and 4.5 g of venlafaxine. Initial assessment revealed a cardiorespiratory stable patient but unresponsive with a GCS of 4 (M2 E1 V1). In the ED, he was intubated, and gastric lavage was performed. Immediately after the admission to the intensive care unit (ICU), his condition quickly deteriorated, developing cardiovascular collapse refractory to crystalloids and vasopressor infusion. Junctional bradycardia occurred, followed by spontaneous conversion to sinus rhythm. Subsequently, frequent ventricular extrasystoles, as well as patterns of bigeminy, trigeminy, and even episodes of non-sustained ventricular tachycardia, occurred. Additionally, generalized tonic–clonic seizures were observed. Alongside supportive therapy, antiarrhythmic and anticonvulsant therapy, intravenous lipid emulsion bolus, and continuous infusion were administered. His condition progressively improved over the following hours, and 24 h later, he was tapered off the vasopressor. On day 2, the patient repeated the cardiovascular collapse and a second dose of ILE was administered. Over the next few days, the patient’s clinical condition improved, and he was successfully weaned off ventilator and vasopressor support. ILE has the potential to become a form of rescue therapy in cases of severe lipophilic drug poisoning and should be considered a viable treatment for severe cardiovascular instability that is refractory to supportive therapy. Full article
(This article belongs to the Special Issue Clinical and Post-Mortem Toxicology)
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