Search Results (284)

Background: Multiple Chemical Sensitivity (MCS) is a complex, disabling condition marked by non-specific symptoms in response to low-level chemical exposures. It often leads to substantial impairments in quality of life, psychological health, and daily functioning. Although non-pharmacological approaches—such as lifestyle and psychological interventions—are widely used, their clinical effectiveness remains unclear. Objective: We aim to evaluate the effectiveness of lifestyle-based approaches in improving clinical and psychosocial outcomes in adults with Multiple Chemical Sensitivity. Methods: A systematic review was conducted in accordance with PRISMA guidelines (PROSPERO: CRD420251013537). Literature searches were carried out in MEDLINE (PubMed), CINAHL, Google Scholar, and ResearchGate between March and April 2025. Eligible studies included adults (≥18 years) with a confirmed diagnosis of MCS and reported outcomes such as perceived stress, anxiety, depressive symptoms, or quality of life. Methodological quality and risk of bias were independently assessed using the PEDro scale, NIH Quality Assessment Tool, CEBMa checklist, and Cochrane RoB 2.0. Results: Twelve studies (N = 378) met the inclusion criteria. Cognitive and behavioral therapies demonstrated the most consistent evidence of efficacy, with reductions in symptom severity, maladaptive cognitive patterns, and functional limitations. Mindfulness-based stress reduction showed favorable outcomes, while other mindfulness-based interventions yielded mixed results. Exposure-based therapies contributed to increased chemical tolerance and reduced avoidance behavior. Electromagnetic and biomedical approaches demonstrated preliminary but limited effectiveness. Aromatherapy was well tolerated and perceived as relaxing, though its clinical impact was modest. Conclusions: Cognitive and behavioral therapies appear to be most effective among lifestyle-based interventions for MCS/IEI. However, study heterogeneity limits the generalizability of findings, underscoring the need for more rigorous research. Full article

Background/Objectives: Daily caloric restriction (DCR) is a common dietary weight loss strategy, but leads to metabolic and behavioral adaptations, including maladaptive eating behaviors and dysregulated appetite. Intermittent fasting (IMF) may mitigate these effects by offering diet flexibility during energy restriction. This secondary analysis compared changes in eating behaviors and appetite-related hormones between 4:3 intermittent fasting (4:3 IMF) and DCR and examined their association with weight loss over 12 months. Methods: Adults with overweight or obesity were randomized to 4:3 IMF or DCR for 12 months. Both randomized groups received a matched targeted weekly dietary energy deficit (34%), comprehensive group-based behavioral support, and a prescription to increase moderate-intensity aerobic activity to 300 min/week. Eating behaviors were assessed using validated questionnaires at baseline and months 3, 6, and 12. Fasting levels of leptin, ghrelin, peptide YY, brain-derived neurotrophic factor, and adiponectin were measured at baseline and months 6 and 12. Linear mixed models and Pearson correlations were used to evaluate outcomes. Results: Included in this analysis were 165 adults (mean ± SD; age 42 ± 9 years, BMI 34.2 ± 4.3 kg/m², 74% female) randomized to 4:3 IMF (n = 84) or DCR (n = 81). At 12 months, binge eating and uncontrolled eating scores decreased in 4:3 IMF but increased in DCR (p < 0.01 for between-group differences). Among 4:3 IMF, greater weight loss was associated with decreased uncontrolled eating (r = −0.27, p = 0.03), emotional eating (r = −0.37, p < 0.01), and increased cognitive restraint (r = 0.35, p < 0.01) at 12 months. There were no between-group differences in changes in fasting appetite-related hormones at any time point. Conclusions: Compared to DCR, 4:3 IMF exhibited improved binge eating and uncontrolled eating behaviors at 12 months. This may, in part, explain the greater weight loss achieved by 4:3 IMF versus DCR. Future studies should examine mechanisms underlying eating behavior changes with 4:3 IMF and their long-term sustainability. Full article

Background/Objectives: Depression is frequently comorbid with obesity. We previously showed that astrocyte-mediated hyperactive ventral hippocampal glutamatergic afferents to the nucleus accumbens determined the exhibition of depression-like behaviors in obese murine models. However, it remains unclear if the metabolic disorder-induced depressive phenotypes and astrocytic maladaptation in the ventral hippocampus (vHPC) could be reversed following the amelioration of key metabolic impairments such as insulin resistance and dyslipidemia. Method: Male mice were fed a high-fat diet (HFD) for 12 weeks, followed by either continued HFD feeding (HFD/HFD group) or a switch to a standard diet for 4 weeks (HFD/SD group). Results: Results showed that HFD/HFD mice displayed not only glucose/lipid metabolic dysfunction, but also depression-like behaviors. In contrast, HFD/SD mice showed improvements in metabolic disorders and depressive phenotypes. Mechanistically, dietary fat reduction restored astrocyte morphology and glutamate transporter expression (GLT-1, GLAST) in the vHPC and suppressed neuroinflammatory signaling, as evidenced by reduced levels of phospho-IKK, TNF-α, IL-1β, and IL-6 in the vHPC. Conclusions: These findings suggest that dietary fat reduction reverses obesity-induced depressive phenotypes, astrocytic deficits, at least in part via suppression of neuroinflammation through the NF-κB signaling pathway. Full article

Background and Objectives: Excessive social media use is repeatedly linked to negative body image outcomes, yet its association with muscle dysmorphia, especially in athletic youth, remains underexplored. We investigated how social media exposure, comparison behavior, and platform engagement relate to muscle dysmorphia symptomatology in young German athletes. Materials and Methods: An anonymous, web-based cross-sectional survey was conducted (July–October 2024) of 540 individuals (45% female; mean age = 24.6 ± 5.3 years; 79% ≥ 3 h sport/week) recruited via Instagram. The questionnaire comprised demographics, sport type, detailed social media usage metrics, and the validated German Muscle Dysmorphic Disorder Inventory (MDDI-1, 15 items). Correlations (Spearman’s ρ, Kendall’s τ) were calculated; multivariate importance was probed with classification-and-regression trees and CatBoost gradient boosting, interpreted via SHAP values. Results: Median daily social media time was 76 min (IQR 55–110). Participants who spent ≥ 60 min per day on social media showed higher MDDI scores (mean 38 ± 7 vs. 35 ± 6; p = 0.010). The strongest bivariate link emerged between perceived social media-induced body dissatisfaction and felt pressure to attain a specific body composition (Spearman ρ = 0.748, Kendall τ = 0.672, p < 0.001). A CatBoost gradient-boosting model out-performed linear regression in predicting elevated MDDI. The three most influential features (via SHAP values) were daily social media time, frequency of comparison with fitness influencers, and frequency of “likes”-seeking behavior. Conclusions: Intensive social media exposure substantially heightens muscle dysmorphia risk in young German athletes. Machine-learning interpretation corroborates time on social media and influencer comparisons as primary drivers. Interventions should combine social media literacy training with sport-specific psychoeducation to mitigate maladaptive comparison cycles and prevent downstream eating disorder pathology. Longitudinal research is warranted to clarify causal pathways and to test targeted digital media interventions. Full article

Background. Cognitive-behavioral theories suggest that obsessions in obsessive-compulsive disorder (OCD) develop from maladaptive misinterpretations and coping strategies of unwanted intrusive thoughts (UITs). Models of Body Dysmorphic Disorder (BDD) and Illness Anxiety Disorder (IAD) propose that these symptoms stem from similar misinterpretations of common UITs relating to perceived defects in appearance and illness. This study examines whether maladaptive misinterpretations and control strategies leading to the escalation of obsessional UITs to OCD symptoms also have a similar effect on the development of BDD and IAD. More specifically, we examined whether misinterpretations and neutralizing responses mediate the associations between the frequency of disorder-specific UITs and symptoms of these disorders. Method. A total of 625 non-clinical participants from four countries completed the Questionnaire of Unpleasant Intrusive Thoughts (QUIT) that assesses OCD, BDD and IAD-related UITs and their associated misinterpretations and neutralizing strategies, as well as self-report measures of OCD, BDD, and IAD symptoms. Parallel multiple mediation models were conducted. Results. The frequency of OCD, BDD and IAD-related UITs predicted symptoms of each disorder. Dysfunctional appraisals and neutralizing behaviors mediated the associations between disorder-specific UITs and symptoms in OCD and IAD. The IAD model accounted for a smaller proportion of variance than the OCD model. No mediating effects were found for BDD symptoms. Conclusions. Experiencing disturbing UITs is a transdiagnostic risk factor of OCD, BDD and IAD, and is associated with symptoms of these disorders. Maladaptive interpretation of UITs and neutralizing strategies should be specific targets in the assessment and treatment of OCD and IAD. The absence of mediation effects for BDD could be due to the limitations observed on the self-report used to assess BDD symptoms and/or the low relevance of the misinterpretations and control strategies assessed by the QUIT, which are more typically endorsed by individuals with OCD. Full article

Exercise addiction (EA) is a maladaptive behavior characterized by excessive physical activity, often linked to negative psychological outcomes. This study investigated the relationships between perfectionism, sport commitment, and EA in a sample of 219 Hungarian athletes (M = 22.19 years). Using path analysis, we tested a model hypothesizing that adaptive and maladaptive perfectionism differentially predict enthusiastic and constrained commitment, which in turn influences EA. Our results showed that maladaptive perfectionism positively predicted constrained commitment (β = 0.70) and EA (β = 0.63), while negatively relating to enthusiastic commitment (β = −0.17). Conversely, adaptive perfectionism was positively associated with enthusiastic commitment (β = 0.24) and negatively with constrained commitment (β = −0.12). Moreover, enthusiastic commitment positively predicted EA (β = 0.24). We found a significant indirect effect between adaptive and maladaptive perfectionism when controlling for enthusiastic commitment, suggesting its dual role in this context. Our study suggests that enthusiastic commitment serves as a source of exercise addiction (EA) and has a dual role, acting as both a protective factor and a risk factor for it. Additionally, we found that maladaptive perfectionism is associated with higher levels of constrained commitment and EA, while correlating with lower levels of enthusiastic commitment. Conversely, adaptive perfectionism increases enthusiastic commitment and decreases constrained commitment. These findings highlight the associations between motivational and personality factors in EA, indicating that even adaptive traits can contribute to unhealthy exercise patterns in athletic environments. Full article

Background/Objectives: A direct link between sensory processing disorder (SPD) and strabismus has not been systematically investigated, though prior studies suggest sensory modulation may influence visual behaviors. Traditional approaches view strabismus through a binary lens—either normal or pathological motor deviation. This report presents a proof-of-concept case suggesting strabismus may represent a neurobehavioral manifestation of sensory processing imbalance, rooted within the broader framework of SPD. Methods: We report a pediatric case marked by episodic monocular eye closure triggered by environmental stimuli, without identifiable ophthalmologic or neurologic pathology. The child’s symptoms were most consistent with sensory over-responsivity (SOR), a subtype of SPD, manifesting as stimulus-bound monocular eye closure and secondary self-regulatory behaviors. Results: We propose the Fusion Dysregulation Hypothesis, suggesting that exotropia and esotropia represent opposing outcomes along a continuum of sensory connectivity: exotropia arising from neural underwiring (hyporesponsivity and fusion instability), and esotropia from overwiring (hyperresponsivity and excessive fusion drive). Our case, marked by sensory hyperresponsivity, showed frequent monocular eye closure that briefly disrupted but did not impair fusion. This suggests an “overwired” binocular system maintaining single vision despite sensory triggers. In early-onset esotropia, such overconnectivity may become maladaptive, leading to sustained convergence. Conversely, autism spectrum disorder, typically associated with hypoconnectivity, may predispose to exotropia through reduced fusion maintenance. Conclusions: These findings highlight the need for interdisciplinary evaluation. We advocate for structured sensory profiling in children presenting with strabismus and, conversely, for ophthalmologic assessment in those diagnosed with SPD. While our findings remain preliminary, they support a bidirectional screening approach and suggest that sensory modulation may play a previously under-recognized role in the spectrum of pediatric strabismus presentations. Full article

Behavioral stress is a recognized triggering factor for systemic diseases, including psychiatric disorders. The stress response is subjected to circadian regulation and many factors shape the susceptibility to its maladaptive consequences, including the biological sex. Accordingly, circadian dysregulation of the stress response, often occurring in a sexually dimorphic manner, is typically associated with psychiatric disorders. However, the interaction between stress, sex, circadian phases, and behavior is still largely unknown. Here, we used the chronic restraint stress (CRS) model in male and female mice to assess the impact of sex and circadian phases on the behavioral consequences of chronic stress. Animals were stressed either in the light or dark phase, and anxious-/depressive-/anhedonic-like behaviors were assessed. Associated transcriptional changes in clock genes were measured in the prefrontal cortex. A significant interaction of stress, sex, and circadian phase was found in most of the parameters evaluated, with no behavioral response to stress in males stressed in the dark phase, and an exaggerated response in females stressed in the dark phase compared to the light phase. We also found some molecular changes in corticosterone serum levels and expression of clock genes in the prefrontal cortex. Full article

Ketamine, originally developed as an anesthetic, is gaining increasing attention due to its multifaceted pharmacological properties. In addition to its use in anesthesia, ketamine exerts potent analgesic effects via N-methyl-D-aspartate (NMDA) receptor antagonism, modulating pain perception and reducing central sensitization, particularly in chronic and neuropathic pain conditions. Emerging evidence also supports ketamine’s potential in the treatment of substance use disorder, where it may disrupt maladaptive reward-related memories and promote neuroplasticity which facilitates behavioral change. Moreover, in recent years, S-ketamine has shown rapid and potent antidepressant effects, especially in treatment-resistant depression (TRD), probably due to increased glutamatergic signaling, synaptic plasticity and the release of neurotrophic factors. This heterogeneous therapeutic profile positions ketamine as a unique agent at the interface of anesthesia, pain management, addiction medicine and psychiatry, warranting further exploration into its mechanism and long-term effectiveness. Full article

This study aims to analyze maladaptive schemas through the Young Schema Questionnaire—Short Form 3 among 895 high school students, with an average age of 18.15 years, in relation to the potentially traumatic experience of being the victim of violence inflicted by family members through hitting and beating and in connection with violent behavior (in and outside school). Almost half of the students reported that, in their families, there were prolonged problems in the couple relationship of their parents/caregivers, and almost 40% of these students were involved from time to time in at least one form of violence in or outside school, with the highest share of this violence resulting from physical aggression by hitting and pushing and verbal or emotional abuse. A factor analysis was performed using a unifactorial model and a mediation model, and it indicated that the presence of trauma increases the total violence score. A higher violence score was recorded in students who were subjected to family violence (t(890) = −6.267, p < 0.001). The schemas that proved to be the most relevant for the violence factor were those of Punitiveness (PU: 0.89) and Mistrust/Abuse (MA: 0.77), followed by the schemas of Emotional Inhibition (EI: 0.68), Unrelenting Standards/Hypercriticalness (US: 0.63), and Entitlement/Grandiosity (ET: 0.58). The mediation that the Punitiveness schema achieves between victimization in the family and subsequent aggressive behavior is based on the internalization of the punitive parental figure and the victim’s development of the belief that violence is the only answer when others do not meet their expectations. Full article

Organisms respond to environmental stress primarily through the autonomic nervous system and hypothalamic–pituitary–adrenal (HPA) axis, regulating metabolism, psychological states, and immune function and modulating memory, reward processing, and immune responses. The HPA axis plays a central role in stress response, exhibiting distinct activation patterns under acute versus chronic social defeat stress. However, differences in physiological impacts and regulatory pathways between these stress conditions remain understudied. This study integrates RNA sequencing and behavioral analyses to reveal that acute social defeat stress triggers transient anxiety-like behaviors, accompanied by systemic inflammation and immediate-early gene (IEG) activation. In contrast, chronic social defeat stress induces long-term behavioral and physiological alterations, including neurotransmitter imbalance (e.g., reduced GABA and increased glutamate), sustained activation of maladaptive pathways (e.g., IL-17 signaling), and disrupted corticosterone synthesis. These findings highlight the dynamic regulatory role of the HPA axis under varying stress conditions, providing novel insights into mental health disorders such as anxiety and depression. The study identifies potential therapeutic targets to mitigate chronic social defeat stress effects and offers a theoretical foundation for personalized interventions. Full article

Major Depressive Disorder (MDD) is a chronic mental disorder characterized by anhedonia, loss of desire, guilt, suicidal thoughts, and appetite changes. It is reported that individuals with MDD resort to binge eating to escape from negative feelings. In this study, we aimed to determine the relationship between binge eating behavior and the concept of psychological pain associated with emotions such as shame, guilt, and anger in individuals with MDD. We conducted the study in the Psychiatry Outpatient Clinics of Balcalı Hospital, Çukurova University Faculty of Medicine. The sample consisted of 147 individuals with MDD without psychotic symptoms and 128 healthy controls with sociodemographic characteristics similar to the MDD group. We administered a sociodemographic data form, the Hamilton Depression Rating Scale (HDRS), Psychache Scale (PS), Tolerance for Mental Pain Scale-10 (TMPS-10), Barratt Impulsiveness Scale (BIS-11), and Eating Disorder Examination Questionnaire (EDE-Q-13). Eighty-two (55.7%) of the patients with MDD were diagnosed with binge eating disorder (BED). In the group of MDD patients with BED comorbidity, the EDE-Q-13 total, binging subscale, and HDRS scores were significantly higher than those of the other groups (p < 0.05 for each group), with large to very large effect sizes (e.g., EDE-Q-13 binging d = 1.04; HDRS d = 1.91; PS d = 1.22). There was no significant difference between the MDD groups (with and without BED) regarding the BIS and BIS subscales’ subscores, PS, and TMPS scores. For participants with MDD, there was a significant same-directional correlation between EDE-Q-13 binging, HDRS, BIS, and PS scores (p < 0.05 for each), with moderate to strong effect sizes (EDE-Q-13 binging and HDRS: r = 0.398, p < 0.001; binging and PS: r = 0.273, p < 0.001; binging and BIS: r = 0.233, p = 0.005; binging and TMPS-10: r = –0.257, p = 0.002). Additionally, a negative correlation was observed between TMPS and the scores for EDE-Q-13 binging, HDRS, BIS, and PS. A linear regression analysis indicated that depression severity and BMI were the strongest predictors of binge eating behavior (R² = 0.243; f² = 0.32). Based on our results, we concluded that the presence of binge eating behavior in patients with MDD is associated with more severe depressive symptoms, psychological pain, impulsivity, and lower tolerance to psychological pain. The finding that binge eating behavior was most strongly associated with depression severity and body mass index (BMI) supports the notion that binge eating behavior is a maladaptive attitude. Longitudinal studies comparing individuals with different BMIs in different clinical samples are needed to confirm our results. Full article

Despite its significance, hysteresis remains underrepresented in mainstream models of plasticity. In this work, we propose a novel framework that explicitly models hysteresis in simple one- and two-neuron models. Our models capture key feedback-dependent phenomena such as bistability, multistability, periodicity, quasi-periodicity, and chaos, offering a more accurate and general representation of neural adaptation. This opens the door to new insights in computational neuroscience and neuromorphic system design. Synaptic weights change in several contexts or mechanisms including, Bienenstock–Cooper–Munro (BCM) synaptic modification, where synaptic changes depend on the level of post-synaptic activity; homeostatic plasticity, where all of a neuron synapses simultaneously scale up or down to maintain stability; metaplasticity, or plasticity of plasticity; neuromodulation, where neurotransmitters influence synaptic weights; developmental processes, where synaptic connections are actively formed, pruned and refined; disease or injury; for example, neurological conditions can induce maladaptive synaptic changes; spike-time dependent plasticity (STDP), where changes depend on the precise timing of pre- and postsynaptic spikes; and structural plasticity, where changes in dendritic spines and axonal boutons can alter synaptic strength. The ability of synapses and neurons to change in response to activity is fundamental to learning, memory formation, and cognitive adaptation. This paper presents simple continuous and discrete neuro-modules with adapting feedback synapses which in turn are subject to feedback. The dynamics of continuous periodically driven Hopfield neural networks with adapting synapses have been investigated since the 1990s in terms of periodicity and chaotic behaviors. For the first time, one- and two-neuron models are considered as parameters are varied using a feedback mechanism which more accurately represents real-world simulation, as explained earlier. It is shown that these models are history dependent. A simple discrete two-neuron model with adapting feedback synapses is analyzed in terms of stability and bifurcation diagrams are plotted as parameters are increased and decreased. This work has the potential to improve learning algorithms, increase understanding of neural memory formation, and inform neuromorphic engineering research. Full article

Background: Emotional dysregulation has been strongly linked to maladaptive eating behaviors in obesity. Worry and rumination are frequently implicated in emotional dysregulation and may serve as pathways linking emotional regulation difficulties to emotional eating. The current study examines the mediating role of worry and rumination in the relationship between emotional dysregulation and emotional eating among individuals with obesity. Methods: Ninety hospitalized Italian adults were involved in the study with 53 obese males, 37 obese females, mean age ± SD: 50.1 + 10.9 years; mean body mass index: 46.4 ± 9.4 kg/m². To assess worry, rumination, emotion dysregulation, and emotional eating, the participants were asked to fill in, respectively, the following questionnaires: The Penn State Worry Questionnaire; The Ruminative Response Scale; The Anger Rumination Scale; The Difficulties in Emotion Regulation Scale; Emotional Eating subscale of the Dutch Eating Behavior Questionnaire. Three mediation models were tested to examine the relationships between difficulties in emotional regulation as a predictor, worry and rumination as mediators separately, and emotional eating as the dependent variable. Results: The mediation analyses revealed significant indirect effects across all models, suggesting the presence of mediation effects of worry and rumination in the relationships between emotional dysregulation and emotional eating. Conclusions: These findings highlight the critical mediating role of worry and rumination that drive the observed relationships between emotional dysregulation and emotional eating. This study contributes to a deeper understanding of the cognitive-emotional mechanisms involved in emotional eating in individuals with obesity. Such results can contribute to developing targeted interventions aimed at improving emotional regulation and reducing maladaptive eating behaviors. Full article

Perceived experiences of violence, trauma, body dissatisfaction, and body shaming emerge as interconnected factors contributing to suicide attempts among adolescents. There is a critical need to improve the understanding and prediction of suicide attempts in this vulnerable population. In this study, a primarily qualitative design was employed, supported by descriptive quantitative elements, such as code frequencies and word clouds, to explore in-depth narrative interviews of adolescents who attempted suicide. Thematic content analysis was utilized to analyze the transcripts of these narrative interviews. The study sample consisted of 22 adolescents (M_age = 16.98 years; SD = 1.624; 77% males, 19% females, 4% non-binary or transgender). The content analysis revealed two significant body-related risk factors for suicide attempts: experiences of violence or trauma and body dissatisfaction, which were associated with maladaptive coping strategies, including self-harm, substance use, and eating disorders. Acute somatic warning signs such as dissociative states, loss of control, and disconnection from one’s body suggested pronounced psychophysiological dysregulation. The findings underscore the body as a battleground, where emotional pain related to bodily experiences and perceptions manifests significantly. Future research should integrate subjective body-related experiences in risk assessments and interventions targeting adolescent suicidal behaviors. Full article