Search Results (101)

Accurate early diagnosis and precise assessment of disease severity are imperative for the treatment and rehabilitation of schizophrenia patients. To achieve this, we propose a computer-aided diagnostic method for schizophrenia that utilizes fusion features derived from microstate analysis and empirical mode decomposition (EMD) based on Electroencephalography (EEG) signals. At the same time, the obtained fusion features from microstate analysis and EMD are input into the Least Absolute Shrinkage and Selection Operator (LASSO) feature selection algorithm to reduce the dimensionality of feature vectors. Finally, the reduced feature vector is fed to a Logistic Regression classifier to classify SCH and healthy EEG signals. In addition, the ability of the integrated features to distinguish the severity of schizophrenia symptoms was evaluated, and the Shapley Additive Explanations (SHAP) algorithm was used to analyze the importance of the classification features that differentiate schizophrenia symptoms. Experimental results from both public and private datasets demonstrate the efficacy of EMD features in identifying healthy controls, while microstate features excel in classifying the severity of symptoms among schizophrenia patients. The classification evaluation metrics of the fused features significantly outperform those obtained using EMD or microstate analysis features independently. The fusion feature method proposed in this study achieved accuracies of 100% and 90.7% for the classification of schizophrenia in public datasets and private datasets, respectively, and an accuracy of 93.6% for the classification of schizophrenia symptoms in private datasets. Full article

This paper addresses the optimization challenges in urban logistics with the aim of enhancing the sustainability of last-mile delivery. By focusing on the collaborative delivery between unmanned aerial vehicles (UAVs) and unmanned ground vehicles (UGVs), we propose a novel approach to reducing energy consumption and operational inefficiencies. A bilevel mixed-integer linear programming (Bilevel-MILP) model is developed, integrating road network topology with dynamic energy constraints. Departing from traditional single-delivery modes, the paper establishes a multi-task continuous delivery framework. By incorporating a dynamic charging point selection strategy and path–energy coupling constraints, the model effectively mitigates energy limitations and the issue of repeated returns for UAV charging in complex urban road networks, thereby promoting more efficient resource utilization. At the algorithmic level, a Collaborative Delivery Path Optimization (CDPO) framework is proposed, which embeds an Improved Sparrow Search Algorithm (ISSA) with directional initialization and a Hybrid Genetic Algorithm (HGA) with specialized crossover strategies. This enables the synergistic optimization of UAV delivery sequences and UGV charging decisions. The simulation results demonstrate that, in scenarios with a task density of 20 per 100 km², the proposed CDPO algorithm reduces the total delivery time by 33.9% and shortens the UAV flight distance by 24.3%, compared to conventional fixed charging strategies (FCSs). These improvements directly contribute to lowering energy consumption and potential emissions. The road network discretization approach and dynamic candidate charging point generation confirm the method’s adaptability in high-density urban environments, offering a spatiotemporal collaborative optimization paradigm that supports the development of sustainable and intelligent urban logistics systems. The obtained results provide practical insights for the design and deployment of efficient UAV–UGV collaborative logistics systems in urban environments, particularly under high-task-density and energy-constrained conditions. Full article

Origin warehouses, positioned at the critical “first mile” of the agri-food supply chain, profoundly influence supply chain power structures and profit allocation, as well as supply chain stability and sustainable development. To explore the role of origin warehouses in the agri-food supply chain, this study develops a three-level game model comprising a “planter–origin warehouse operator–seller” framework. Notably, this study conceptualizes the dual-functional “origin warehouse” as observed in practice, proposing two theoretical modes: the Logistics Center (LC) and the Supply Chain Center (SCC). By treating quality level, service level, and selling price decisions as endogenous variables, this study further reveals the interconnected decision-making mechanisms under different operational modes. Overall, the LC mode performs better in quality-driven markets, generating higher system profits and greater social welfare, whereas the SCC mode is superior when consumers are more price-sensitive or place greater value on service. Based on these findings, this study provides decision-making guidance for origin warehouse operators aiming to select the optimal mode under varying market conditions and proposes targeted coordination strategies to promote the high-quality development and economic sustainability of the agri-food supply chain. Full article

Characterized by zero-carbon, congestion-free, and high-capacity features, the utilization of metro systems for collaborative passenger-and-freight transport (the metro-based underground logistics system, M-ULS) has been recognized as a favorable alternative to facilitate automated freight transport in future megacities. This article constructs a three-echelon M-ULS network and establishes a multi-objective bilevel programming model, considering the interests of both government investment departments and transport enterprises. The overall goal of the study is to establish a transportation network with the lowest construction cost, lowest operating cost, and highest facility utilization rate, taking into account factors such as population density, transportation conditions, land resources, logistics demand, and metro station location, under given cost parameters and demand conditions. The upper-level model takes government investment as the main body and aims to minimize the total cost, establishing an optimization model for location selection allocation paths with capacity constraints; the lower-level model aims to minimize the generalized cost for freight enterprises by simulating the competition between traditional transportation and the M-ULS mode. In addition, a bi-level programming model solving framework was established, and a multi-stage precise heuristic hybrid algorithm based on adaptive immune clone selection algorithm (AICSA) and improved plant growth simulation algorithm (IPGSA) is designed for the upper-level model. Finally, taking the central urban area of Beijing as an example, four network scales are set up for numerical simulation research to verify the reliability and superiority of the model and algorithm. By analyzing and setting key indicators, an optimal network configuration scheme is proposed, providing a feasible path for cities to improve logistics efficiency and reduce the impact of logistics externalities under limited land resources, further strengthening the strategic role of subway logistics systems in urban sustainable development. Full article

Pharmaceutical manufacturing and logistics rely on accurate prediction and decision making to safeguard product quality, delivery reliability, and patient outcomes. Despite rapid advances in artificial intelligence (AI) and machine learning (ML), few studies benchmark model performance across the diverse operational demands of global pharmaceutical supply chains. Predictive setbacks contribute to financial losses, reduced supply chain efficacy, and potential adverse health consequences, yet understanding these failures offers firms opportunities to refine strategy and strengthen resilience. Drawing on 1.2 million shipments spanning 39 countries, we compare traditional statistical models (ARIMA), ensemble methods (random forests, gradient boosting), and deep neural networks (LSTM, GRU, CNN, ANN) across pricing, demand forecasting, vendor management, and shipment planning. Gradient boosting produced the strongest pricing performance, while ARIMA delivered the lowest demand-forecasting errors but with limited explanatory power; neural networks captured nonlinear demand shocks and achieved superior maintenance-risk classification. We also identified three vendor performance clusters—high-performing, cost-efficient, and mixed-reliability vendors—enabling firms to better align shipment criticality with vendor capabilities by prioritizing high performers for urgent deliveries, leveraging cost-efficient vendors for non-urgent volumes, and managing mixed performers through targeted oversight. These insights highlight the value of our evidence-based roadmap for selecting algorithms in high-stakes healthcare logistics, in rapidly evolving, technologically complex global contexts where increasing algorithmic sophistication elevates the standards for safer, smarter pharmaceutical supply chains. Full article

Healthcare systems worldwide have faced unprecedented pressure during crises such as the COVID-19 pandemic, exposing limits in managing scarce hospital resources. Many predictive models remain static, unable to adapt to new variants, shifting conditions, or diverse patient populations. This work proposes a dynamic prioritization framework that recalculates severity scores in batch mode when new factors appear and applies them instantly through a streaming pipeline to incoming patients. Unlike approaches focused only on fixed mortality or severity risks, our model integrates dual datasets (survivors and non-survivors) to refine feature selection and weighting, enhancing robustness. Built on a big data infrastructure (Spark/Databricks), it ensures scalability and responsiveness, even with millions of records. Experimental results confirm the effectiveness of this architecture: The artificial neural network (ANN) achieved 98.7% accuracy, with higher precision and recall than traditional models, while random forest and logistic regression also showed strong AUC values. Additional tests, including temporal validation and real-time latency simulation, demonstrated both stability over time and feasibility for deployment in near-real-world conditions. By combining adaptability, robustness, and scalability, the proposed framework offers a methodological contribution to healthcare analytics, supporting fair and effective hospitalization prioritization during pandemics and other public health emergencies. Full article

For effective logistics planning and pricing strategies, it is essential to predict road freight transportation costs accurately. Using a real-world dataset with 45,569 freight offers and 52 different variables, including financial, logistical, geographical, and temporal characteristics, this study presents a data-driven method for forecasting transport prices. To create a strong predictive model, the approach combines hyperparameter optimization, evolutionary feature selection, and extensive feature engineering. Because gradient boosting works well for modelling intricate, nonlinear relationships, it was used as the main algorithm. Temporal dependencies were maintained through a nested cross-validation framework with a time-series split, which improved the generalizability of the model. With a mean absolute percentage error (MAPE) of 6.27%, the model showed excellent predictive accuracy. Key predictive factors included total transport distance, load and delivery quantities, temperature constraints, and aggregated categorical features such as route and vehicle type. The results confirm that evolutionary algorithms are capable of efficiently optimizing model parameters, as well as feature subsets, greatly enhancing interpretability and performance. In the freight logistics industry, this method offers useful insights for operational and dynamic pricing decision-making. This model may be expanded in future research to include external data sources and investigate its suitability for use in various geographic locations and modes of transportation. Full article

To align with the adoption of electric vehicles in the transportation sector, this paper proposes the use of electric heavy-duty trucks for the logistics and distribution of large prefabricated building components. This approach aims to address the problems of high total costs and significant energy waste in prefabricated component transportation. Focusing on the multi-to-multi distribution mode, a two-level optimization model is constructed. The upper-level model is responsible for the reasonable allocation of demand points. The lower-level model optimizes the selection of road network nodes and charging stations along the delivery routes. It also dynamically adjusts charging timing and volume according to the real-time power situation. To enhance solution performance, a two-level multi-objective evolutionary algorithm based on Pareto theory is designed. This algorithm simultaneously optimizes distribution costs while coordinating path planning and charging strategies. Comparative experiments across different cases show that, compared with traditional single-level and multi-stage models, the proposed algorithm improves both solution accuracy and quality. Additionally, when compared with the scheduling scheme based on the full-charge capacity strategy, the dynamic charging strategy proposed in this paper reduces the total distribution cost by approximately 15.83%. These findings demonstrate that the constructed model and algorithm can effectively optimize the logistics and distribution of prefabricated components. They also provide a feasible solution for the practical application of electric vehicles in engineering logistics. Full article

In this paper, we develop a dynamic pricing mechanism for a meal delivery platform that offers multiple transportation modes for order deliveries. We consider orders from heterogeneous customers who select their preferred delivery mode based on individual generalized cost (GC) functions, where GC captures the trade-off between price and delivery latency for each transportation option. Given the logistics of the underlying transportation network, the platform can utilize a pricing mechanism to guide customer choices toward delivery modes that optimize resource allocation across available transportation modalities. By accounting for variability in the latency and cost of modalities, such pricing aligns customer preferences with the platform’s operational objectives and enhances overall satisfaction. Due to the computational complexity of finding the optimal policy, we adopt a deep reinforcement learning (DRL) approach to design the pricing mechanism. Our numerical results demonstrate up to $143\%$ higher profits compared to heuristic pricing strategies, highlighting the potential of DRL-based dynamic pricing to improve profitability, resource efficiency, and service quality in on-demand delivery services. Full article

Background: Electrocardiograms (EKGs) are essential tools in emergency medicine, often used to evaluate chest pain, dyspnea, and other symptoms suggestive of cardiac dysfunction. Yet, EKGs are not universally administered to all emergency department (ED) patients. Understanding and predicting which patients receive an EKG may offer insights into clinical decision making, resource allocation, and potential disparities in care. This study examines whether integrating structured clinical data with free-text patient narratives can improve prediction of EKG utilization in the ED. Methods: We conducted a retrospective observational study to predict electrocardiogram (EKG) utilization using data from 13,115 adult emergency department (ED) visits in the nationally representative 2021 National Hospital Ambulatory Medical Care Survey–Emergency Department (NHAMCS-ED), leveraging both structured features—demographics, vital signs, comorbidities, arrival mode, and triage acuity, with the most influential selected via Lasso regression—and unstructured patient narratives transformed into numerical embeddings using Clinical-BERT. Four supervised learning models—Logistic Regression (LR), Support Vector Machine (SVM), Random Forest (RF) and Extreme Gradient Boosting (XGB)—were trained on three inputs (structured data only, text embeddings only, and a late-fusion combined model); hyperparameters were optimized by grid search with 5-fold cross-validation; performance was evaluated via AUROC, accuracy, sensitivity, specificity and precision; and interpretability was assessed using SHAP values and Permutation Feature Importance. Results: EKGs were administered in 30.6% of adult ED visits. Patients who received EKGs were more likely to be older, White, Medicare-insured, and to present with abnormal vital signs or higher triage severity. Across all models, the combined data approach yielded superior predictive performance. The SVM and LR achieved the highest area under the ROC curve (AUC = 0.860 and 0.861) when using both structured and unstructured data, compared to 0.772 with structured data alone and 0.823 and 0.822 with unstructured data alone. Similar improvements were observed in accuracy, sensitivity, and specificity. Conclusions: Integrating structured clinical data with patient narratives significantly enhances the ability to predict EKG utilization in the emergency department. These findings support a personalized medicine framework by demonstrating how multimodal data integration can enable individualized, real-time decision support in the ED. Full article

The four-way shuttle storage and retrieval system (FWSS/RS) is an advanced automated warehousing solution for achieving green and intelligent logistics, and task allocation is crucial to its logistics efficiency. However, current research on task allocation in three-dimensional storage environments is mostly conducted in the single-operation mode that handles inbound or outbound tasks individually, with limited attention paid to the more prevalent composite operation mode where inbound and outbound tasks coexist. To bridge this gap, this study investigates the task allocation problem in an FWSS/RS under the composite operation mode, and deep reinforcement learning (DRL) is introduced to solve it. Initially, the FWSS/RS operational workflows and equipment motion characteristics are analyzed, and a task allocation model with the total task completion time as the optimization objective is established. Furthermore, the task allocation problem is transformed into a partially observable Markov decision process corresponding to reinforcement learning. Each shuttle is regarded as an independent agent that receives localized observations, including shuttle position information and task completion status, as inputs, and a deep neural network is employed to fit value functions to output action selections. Correspondingly, all agents are trained within an independent deep Q-network (IDQN) framework that facilitates collaborative learning through experience sharing while maintaining decentralized decision-making based on individual observations. Moreover, to validate the efficiency and effectiveness of the proposed model and method, experiments were conducted across various problem scales and transport resource configurations. The experimental results demonstrate that the DRL-based approach outperforms conventional task allocation methods, including the auction algorithm and the genetic algorithm. Specifically, the proposed IDQN-based method reduces the task completion time by up to 12.88% compared to the auction algorithm, and up to 8.64% compared to the genetic algorithm across multiple scenarios. Moreover, task-related factors are found to have a more significant impact on the optimization objectives of task allocation than transport resource-related factors. Full article

The contemporary development of e-commerce in recent years has contributed to the rapid growth of the logistics industry and its awareness of environmental threats. Alongside the increase in online orders, significant environmental pollution has emerged in the logistics sector. Logistics operators are striving to build green logistics policies, and the reliability of the supply chain and the analysis of innovation strategies in green logistics have contributed to the improvement of environmental pollution in the logistics industry and reduced vehicle emissions in transportation. The aim of this study is to assess the implementation of the green logistics concept by selected logistics operators in Poland. The research indicates an increase in exhaust emissions of all harmful compounds in the analyzed transport logistics system by 2030 at the following selected logistics operators: CO, 9.167%; HC, 16.265%; and NOX, 17.354%. According to EU documents, the objectives to be achieved in terms of sustainable development in the field of transport, including for the logistics sector, are to change sustainable propulsion systems, and to optimize the operation of multimodal logistics chains, inter alia, by making greater use of more energy-efficient modes of transport. Full article

Blood microsampling (BμS) has recently emerged as an interesting approach in the analysis of endogenous metabolites but also in metabolomics applications. Their non-invasive way of use and the simplified logistics that they offer renders these technologies highly attractive in large-scale studies, especially the novel quantitative microsampling approaches such as VAMs or qDBS. Objectives: Herein, we investigate the potential of BµS devices compared to the conventional plasma samples used in global untargeted mass spectrometry-based metabolomics of blood. Methods: Two novel quantitative devices, namely, Mitra, Capitainer, and the widely used Whatman cards, were selected for comparison with plasma. Venous blood was collected from 10 healthy, overnight-fasted individuals and loaded on the devices; plasma was also collected from the same venous blood. An extraction solvent optimization study was first performed on the three devices before the main study, which compared the global metabolic profiles of the four extracts (three BµS devices and plasma). Analysis was conducted using reverse phase LC-TOF MS in positive mode. Results: BµS devices, especially Mitra and Capitainer, provided equal or even superior information on the metabolic profiling of human blood based on the number and intensity of features and the precision and stability of some annotated metabolites compared to plasma. Despite their rich metabolic profiles, BµS did not capture metabolites associated with biological differentiation of sexes. Conclusions: Overall, our results suggest that a more in-depth investigation of the acquired information is needed for each specific application, as a metabolite-dependent trend was obvious. Full article

Utilization of biomass through anaerobic digestion and hydrothermal carbonization is crucial to maximize resource efficiency. At the same time, supply chain integration ensures sustainable feedstock management and minimizes environmental and logistical impacts, enabling a holistic approach to a circular bioeconomy. This study presents an integrated approach to simultaneously optimize the biomass supply chain network and process flowsheet, which includes anaerobic digestion, cogeneration, and hydrothermal carbonization. A three-layer supply chain network superstructure was hence developed to integrate the optimization of process variables with supply chain features such as transportation modes, feedstock supply, plant location, and demand location. A mixed-integer nonlinear programming model aimed at maximizing the economic performance of the system was formulated and applied to a case study of selected regions in Slovenia. The results show a great potential for the utilization of organic biomass with an annual after tax profit of 23.13 million USD per year, with the production of 245.70 GWh/yr of electricity, 298.83 GWh/yr of heat, and 185.08 kt/yr of hydrochar. The optimal configuration of the supply chain network, including the selection of supply zones, plant locations and demand locations, transportation links, and mode of transportation is presented, along with the optimal process variables within the plant. Full article

To investigate the dynamic complexity of chain-to-chain output decisions in a closed-loop supply chain system of cross-border e-commerce (CBEC), this study decomposes the system into four product–market (PM) chains, based on the e-commerce platform’s information-sharing strategy and the manufacturer’s selected logistics mode (direct mail or bonded warehouse). By combining game theory with complex systems theory, discrete dynamic models for output competition among PM chains under four scenarios are constructed. The Nash equilibrium solution and stability conditions of the models are derived according to the principles of nonlinear dynamics. The stability of the model under the four scenarios, as well as the impacts of the initial output level and comprehensive tax rates on the stability and stability control of the system, are analyzed using numerical simulation methods. Our findings suggest that maintaining system stability requires controlling the initial output levels, the output adjustment speeds, and tariff rates to remain within specific thresholds. When these thresholds are exceeded, the entropy value of the model increases, and the system outputs decisions to enter a chaotic or uncontrollable state via period-doubling bifurcations. When the output adjustment speed of the four PM chains is high, the direct-mail logistics mode exhibits greater stability. Furthermore, under increased tariff rates for CBEC, the bonded warehouse mode has a stronger ability to maintain stability in system output decisions. Conversely, when the general import tax rate increases, the direct-mail mode demonstrates better stability. Regardless of the logistics mode, the information-sharing strategy can enhance the stability of system output decisions, while increased e-commerce platform commission rates tend to reduce stability. Interestingly, the use of a non-information-sharing strategy and the direct-mail logistics mode may be more conducive to increasing the profit levels of overseas manufacturers. Finally, the delayed feedback control method can effectively reduce the entropy value, suppress chaotic phenomena in the system, and restore stability to output decisions from a fluctuating state. Full article