Search Results (13,141)

Background/Objectives: Youth with type 1 diabetes (T1DM) face unique challenges in balancing dietary choices, physical health outcomes, and social–emotional well-being in school settings. This cross-sectional exploratory pilot study examined the associations of diet with physical health and teacher-reported social–emotional functioning in students with T1DM. Methods: Students with T1DM (mean age = 13.42; 47 female, 50 male; 50% White, Non-Hispanic, 50% minority) self-reported their nutritional habits using the KBlock Dietary Screener for Children when school was in session. Teacher-rated school-related behaviors were assessed through the Behavior Assessment Scale for Children-2nd Edition (BASC-2). Canonical correlation analysis was conducted to determine whether the variable sets (diet with physical health and school-related behavioral health) shared a significant multivariate relationship. Results: Youth with lower glycemic loads and consuming more sugar, dairy, and meat/poultry/fish but fewer legumes, fruit, and less saturated fat exhibited fewer externalizing symptoms and higher BMI. Diet uniquely accounted for modest variance in combined social–emotional and physical health, controlling for demographics and T1DM duration. Findings support increasing the availability of whole, nutrient-rich foods, integrating comprehensive nutrition education into curricula, and ensuring access for all students, regardless of socioeconomic status. Conclusions: Comprehensive dietary assessments and school-based randomized control trials are needed to enact more evidence-based dietary recommendations or interventions for youth, aiming for a balanced approach that addresses both mental and physical health outcomes. Full article

Background: Vitamin D deficiency (VDD) is highly prevalent among people living with human immunodeficiency virus (HIV), with reported rates of insufficiency and deficiency substantially higher than in many general-population cohorts. This study aims to assess the prevalence of vitamin D deficiency and to investigate the risk factors contributing to its occurrence among people living with HIV who are receiving antiretroviral therapy (ART) and are registered at the Craiova Regional Center (CRC). Methods: A retrospective study was conducted from May 2024 to August 2024, including individuals with HIV aged 18 years and older who were registered at the CRC. Results: A total of 138 patients were included in the study. The prevalence of vitamin D deficiency (<20 ng/mL) and vitamin D insufficiency (20–29.9 ng/mL) was 36.2% and 33.3%, respectively, with an average vitamin D level of 26.4 ± 9.9 ng/mL. Vitamin D deficiency was associated with obesity (p = 0.0013), high HIV viral load (p = 0.043), low CD4 nadir (<200 cells/mm³, p = 0.006), prolonged ART exposure (p = 0.002), and the use of tenofovir disoproxil fumarate or protease inhibitor-containing regimens (p = 0.034 and p = 0.016, respectively). Conclusions: These findings indicate that monitoring vitamin D levels could be particularly relevant for patients with HIV with higher-risk profiles. However, our study included a relatively small number of participants, so further research in larger cohorts is needed to better understand these patterns. Full article

Corn fermentation in biorefineries produces residual biomass and by-products, particularly corn kernel fiber and outgassed carbon dioxide (CO₂), that have value-added potential for improving sugar and bioethanol conversions. Recovered corn kernel fiber contains lignocellulosic components which can be made accessible by pretreating the biomass with an alkaline sodium carbonate solution made with captured CO₂ and then used as supplemental biomass in corn ethanol production. In this work, different ratios of whole and degermed corn kernel fibers are pretreated and mixed with corn to be evaluated as beneficial ingredients in bioethanol co-fermentation. Sugar yields from enzymatic hydrolysis demonstrate the pretreatment promotes saccharification reaching over 70% total sugar conversion for the whole corn fibers. During co-fermentation, 10 and 20% corn solid loadings significantly increased ethanol yields while additional corn fiber loadings increased sugar yields. Conversion rates and yields were similar between the whole and degermed corn fibers supporting how a single recovery design can benefit multiple corn streams. Full article

This study presents a standardized method for multimodal monitoring of exercise execution in isolated, confined, and extreme (ICE) environments, addressing the need for reproducible assessment of neuromuscular and cardiovascular responses under space- and equipment-limited conditions. The method integrates wearable surface electromyography (sEMG), inertial measurement units (IMU), and electrocardiography (ECG) to capture muscle activation, movement, and cardiac dynamics during space-efficient exercise. Ten exercises suitable for confined habitats were implemented during analog missions conducted in the DeepLabH03 facility, with feasibility evaluated in a seven-day campaign involving three adult participants. Signals were synchronized using video-verified repetition boundaries, sEMG was normalized to maximum voluntary contraction, and sEMG amplitude- and frequency-domain features were extracted alongside heart rate variability indices. The protocol enabled stable real-time data acquisition, reliable repetition-level segmentation, and consistent detection of muscle-specific activation patterns across exercises. While amplitude-based sEMG indices showed no uniform main effect of exercise, robust exercise-by-muscle interactions were observed, and sEMG mean frequency demonstrated sensitivity to differences in movement strategy. Cardiac measures showed limited condition-specific modulation, consistent with short exercise bouts and small sample size. As a proof-of-concept feasibility study, the proposed protocol provides a practical and reproducible framework for multimodal physiological monitoring of exercise in ICE analogs and other constrained environments, supporting future studies on exercise quality, training load, and adaptive feedback systems. The protocol is designed to support near-real-time monitoring and forms a technical basis for future exercise-quality feedback in confined habitats. Full article

Design education involves complex historical knowledge structures that often impose a high extraneous cognitive load on students. This study proposes and evaluates an intelligent instructional system that integrates Retrieval-Augmented Generation (RAG) with anthropomorphic digital humans to function as scalable cognitive scaffolding. We developed a locally deployed architecture utilizing the Qwen3-30B Large Language Model (LLM) for reasoning, BGE-Large-Zh for high-precision semantic embedding, and LiveTalking for real-time audiovisual generation. To validate the system’s pedagogical efficacy, a multi-center randomized controlled trial (RCT) was conducted across three universities ($N = 150$). The experimental group utilized the RAG-enhanced digital human system, while the control group received traditional instruction. Quantitative results demonstrate that the system significantly improved learning outcomes ($p<0.001, Cohen’s d=1.14$) and classroom engagement ($p<0.001, d=1.39$). Crucially, measurements using the Paas Mental Effort Rating Scale revealed a significant reduction in mental effort ($p<0.001, d=1.71$) for the experimental group. Instructional efficiency analysis (E) confirmed that the system successfully converted reduced extraneous load into germane learning gains (Experimental $E=+0.72$ vs. Control $E=-0.68$). These findings validate the technical feasibility and educational value of combining localized RAG architectures with embodied AI, offering a replicable framework for reducing cognitive load in intensive learning environments. Full article

This study presents a structured evaluation framework for inter-module connections in the context of steel–concrete composite modular structures, addressing a gap in existing reviews that have focused almost exclusively on steel modular systems. The paper examines tie-rod (TR), locking mechanism (LM), and bolted inter-module connections, while introducing a new sub-classification of bolted connections into direct bolted (DB) and plug-assisted bolted (PB) types based on assembly methods. A novel four-metric, five-point rating framework is introduced to assess the Composite Compatibility Score (CCS), proposed as a new metric to evaluate the applicability of steel-oriented connections to composite modules; the Validation Evidence Score (VES), which reflects the extent of experimental and numerical validation; the Demountability and Reusability Score (DRS), which measures the ease of assembly and disassembly; and the newly developed Normalised Capacity Index (NCI), which standardises structural capacity assessment across studies reporting different load capacity types. When applied to nearly 50 inter-module connections, the framework reveals that PB connections provide the most well-rounded performance across all evaluation metrics. Overall, the framework establishes a conceptual benchmark for composite modular connection technologies, providing a basis for future research and design practice. Full article

Chinese rice-field eel rhabdovirus (CrERV) is a serious epidemic pathogen of Chinese rice-field eel and causes severe economic losses to aquaculture. However, there are no commercial drugs presently available to control CrERV infection. Eugenol is a bioactive compound extracted from clove plants and exhibits potential antiviral activity. In the study, the antiviral activity of eugenol against CrERV was investigated in Chinese rice-field eel (Monopterus albus). Eugenol reached the highest inhibition rate of 96.6% at 40 mg/L in Chinese rice-field eel kidney cells (CrEK). Notably, eugenol exhibits antiviral activity by directly targeting CrERV and additionally confers prophylactic effects against infection via its action on CrEK cells. The results of exploring the viral invasion cycle demonstrated that eugenol primarily exerted its antiviral effect during the middle stage and late stage (12 h and 24 h) of viral infection. In addition, eugenol inhibited CrERV-induced apoptosis of CrEK cells, maintained mitochondrial membrane potential levels, maintained physiological cellular morphology and structure, and protected cells from loss of cellular morphology, formation of apoptotic vesicles, and cell fragmentation. For the in vivo study, eugenol increased the survival rate of CrERV-infected rice-field eel by 56% and 48%, in prevention experiments and treatment experiments, respectively. Concurrently, eugenol significantly reduced viral loads and induced the upregulation of anti-inflammatory and antioxidant genes, indicating its potential for immunoregulation. In summary, eugenol holds potential for both preventing and treating CrERV infections in the aquaculture context. Full article

New-generation communications aim for ubiquitous and pervasive communications with high data rates. Electromagnetic spectrum saturation and increasing data volumes can employ the use of free-space optical communication to ease capacity loads in modern networks. In this writing, we review the impact of the atmospheric channel on the optical signal dynamics for long-range data links between high-speed and maneuverability suborbital platforms in full atmosphere. This work presents the main propagation constraints, such as path loss, turbulence, and aero-optics, which are environment-dependent and geometry-dependent for this worst-case scenario. To carry out our study, we recall experimental results collected in the literature since the early times, showing system constraints and performance limits. This provides a historical timeline perspective. Theoretical models and channel management techniques that appeared through time are briefly summarized, and their impact on link budget and stability on reference link geometries is addressed through analytical simulation. In conclusion, this paper shows that an integrated approach to this kind of link is successful mainly with a convergence of mitigation techniques and tailored engineering, which cannot neglect the knowledge of the operating environment and strongly relies on accurate physics modeling, which remains an area of active open research. Full article

Container-based cloud platforms enable flexible and lightweight application deployment, yet container scheduling remains challenged by resource fragmentation, load imbalance, excessive energy consumption, and service-level agreement (SLA) violations. To address these issues, this paper proposes a hybrid multi-objective optimization approach, termed HHO-GWO, which combines Harris Hawks Optimization (HHO) with the Grey Wolf Optimizer (GWO) for container initial placement in cloud environments. A unified fitness function is designed to jointly consider resource utilization, load balancing, resource fragmentation, energy consumption, and SLA violation rate. In addition, a dynamic weight adjustment mechanism and Lévy flight perturbation are incorporated to improve search adaptability and prevent premature convergence. The proposed method is evaluated through extensive simulations under different workload scales and compared with several representative metaheuristic algorithms. The results show that HHO-GWO achieves improved convergence behavior, solution quality, and stability, particularly in large-scale container deployment scenarios. These findings suggest that the proposed approach provides a practical and energy-aware solution for multi-objective container scheduling in cloud data centers. Full article

The fire performance of existing reinforced concrete (RC) bridge decks strengthened by external prestressing systems is investigated, with particular attention to the vulnerability of externally applied tendons under realistic fire scenarios. Fire exposure represents a critical condition for such retrofitted structures, as the structural response is strongly influenced by load level, prestressing effectiveness, and thermal degradation of the strengthening system. A comprehensive assessment framework is proposed, combining thermal and mechanical analyses applied to representative highway overpass bridges. The thermal input adopted for the analyses is first validated through computational fluid dynamics (CFD) simulations, aimed at evaluating temperature development in typical RC beam–girder grillage decks subjected to fire from below. The CFD study considers variations in clearance height and span length and confirms that, in the case of hydrocarbon tanker accidents with fuel spilled on the roadway, conventional fire curves commonly adopted in the literature provide a reliable and conservative representation of both the temperature levels reached and their rate of increase within structural elements, thus supporting their use for rapid and simplified assessments. The validated thermal input is then employed in an analytical fire safety procedure applied to several realistic bridge case-studies. A parametric investigation is carried out by varying deck geometry, span length, reinforcement layout, and the presence of external prestressing retrofit, allowing the evaluation of the reduction in bending capacity and the time-dependent degradation of mechanical properties under fire exposure. The results highlight the critical role of external prestressing in fire scenarios, showing that significant loss of prestressing effectiveness may occur within the first minutes of fire, potentially leading to critical conditions even at service load levels. Finally, a multi-hazard assessment is performed by combining fire effects with pre-existing aging-related deterioration, such as reinforcement corrosion and long-term prestressing losses, demonstrating a marked increase in failure risk and, in the most severe cases, the possibility of premature collapse under dead loads. Full article

Jaw fracture management significantly advanced with the introduction of Erich Arch Bars (EABs) during World War II, becoming the gold standard for maxillomandibular fixation (MMF). EABs, however, are time-consuming, pose risks of sharps injuries, and hinder oral hygiene and patient comfort. This study tested the Minne Ties Hybrid Arch Bar System (MTHAB), a novel MMF technology. This cadaveric study used specimens with near-complete dentition to compare MTHAB and EABs. The technologies were applied by trained surgeons to measure occlusal forces, increasing elastic loads, and application and removal times. Surgeons completed structured usability surveys. The results indicated that MTHAB significantly reduced application time (19.8 ± 4.1 min versus 35.2 ± 5.7 min, p = 0.0027) and removal time (1.6 ± 0.4 min versus 5.1 ± 2.1 min, p = 0.0465) compared to EABs, while also being rated higher for ease of use and safety. Both technologies achieved acceptable occlusion forces, although MTHAB needed more elastics to achieve comparable forces to EABs. While MTHAB appears promising, future clinical trials are needed to evaluate long-term outcomes, fixation stability, and patient selection. MTHAB represents a potential advancement in MMF technology, balancing surgical efficiency, safety, and fixation strength. Full article

This paper proposes a dynamic voltage restorer (DVR) based on a new three-phase multilevel inverter (MLI). An integral component of DVRs is the power electronic converter. At medium-to-high voltage levels, MLIs are the ideal converters for DVR applications because lower voltage-rated switches are used to generate high voltages, thus minimizing power losses. The proposed three-phase MLI generates 15 levels of load voltage per phase, using a reduced component count: eight lower-rated semiconductor power switches, four primary DC voltage sources, two auxiliary DC sources, and eight driver circuits per phase. Additionally, each phase features a low-frequency transformer with voltage-boosting and galvanic isolation capabilities. The switching sequence of the proposed MLI is simpler to execute using fundamental frequency control; this methodology provides reduced switching stress and reduced switching losses as merits. Structurally, the proposed MLI is less complex and thus scalable. The proposed DVR, based on three-phase MLI, efficiently offsets power quality problems such as voltage swell, voltage sags, and harmonics for balanced and unbalanced loads. The operational performance of the proposed DVR-MLI is verified by a simulation, using PSCAD software and an experimental prototype. Full article

Background: This study examines how contextual factors influence the match load experienced by U14 athletes. Methods: Ninety-six male players from eight Portuguese regional selection teams were monitored during three official matches each, using WIMU Pro™ inertial devices with ultra-wideband (UWB) tracking systems. Fifteen internal and external load variables were analyzed, including player load/min, high-speed running (HSR), maximum heart rate (HRmax), and high impacts/min. Mixed linear models revealed significant inter-individual variability in all variables, showing sensitivity to match context. Results: Losing teams exhibited higher player load/min. Balanced matches provoked greater cardiovascular and locomotor demands, particularly in HRmax and HSR metrics. Cluster analysis identified three match typologies based on score margin. Team level was strongly associated with final outcomes and quarter performance, reinforcing the predictive value of intra-match consistency. In contrast, match type (score margin) showed limited correlation with team quality or load distribution. Conclusions: These findings demonstrate the multifactorial nature of match load in youth basketball, supporting the implementation of individualized, context-aware training and recovery strategies while guiding long-term athlete development. Full article

Acetyl phosphate (AcP) is a microbial metabolite acting as a link between cell metabolism and signaling, providing the survival of bacteria in the host. AcP was also identified as an intermediate of pyruvate oxidation in mammalian mitochondria and was found in the human blood in some severe pathologies. The possible contribution of circulating AcP to the maintenance of the physiological or pathological states of the body has not been studied. Since AcP can function as a donor of phosphate groups, we have examined in vitro the influence of AcP on calcium signaling in mitochondria and cells by measuring the membrane potential and the calcium retention capacity of mitochondria by selective electrodes and by assaying the cell calcium signaling by Fura-2AM fluorescent radiometry. AcP was shown to induce a concentration-dependent increase in the mitochondrial resistance to calcium ion loading both in the control and in the presence of ADP. This effect was especially pronounced when mitochondria were incubated in a phosphate-free medium; under these conditions, AcP strongly raised the membrane potential and increased the rate of calcium uptake and the calcium retention capacity several times. Moreover, AcP induced similar changes in human cells when calcium signaling was activated by ATP, to a greater extent in neuroblastoma cells than in astrocytes. In the presence of AcP, a tendency for an increase in the amplitude and a decrease in the continuance of the ATP-induced calcium response was observed. These changes are probably associated with the activation of calcium buffering by mitochondria due to the delivery of phosphate during the hydrolysis of AcP. The results show that AcP is involved in the regulation of the Ca²⁺ balance in cells by activating the accumulation of calcium ions by mitochondria, especially under phosphate deficiency. A shift in calcium signaling mediated by AcP supplementation may be caused by hyperphosphatemia, which is now considered as one of basic contributors to cellular dysfunction and progression of various diseases, including sepsis. Full article

Modern agriculture faces the critical need to develop sustainable, safe, and effective strategies for enhancing productivity, protecting plants and animals, and ensuring food security. Challenges posed by antibiotic resistance and the adverse environmental and consumer health impacts of chemical agents are driving the search for eco-friendly alternatives. In this context, bacteriocins—naturally occurring antimicrobial peptides synthesized by diverse bacteria—represent a promising alternative to traditional chemical compounds. This article reviews the potential and current advances in bacteriocin applications across agricultural sectors, with particular focus on their targeted antagonistic activity, structural diversity, commercial bacteriocin-based products, and their utilization in livestock farming, crop production, poultry farming, and aquaculture. Key findings demonstrate that bacteriocins, particularly nisin and pediocin PA-1, exhibit potent activity against major agricultural pathogens including Listeria monocytogenes, Staphylococcus aureus, Clostridium perfringens, and Escherichia coli, with efficacy rates reaching 90% in mastitis treatment and significantly reducing pathogen loads in poultry and aquaculture systems. Commercial products such as Nisaplin, Wipe Out, and ALTA 2431 have been successfully implemented in veterinary medicine and food production. In aquaculture, bacteriocins effectively control Lactococcus garvieae, Aeromonas spp., Vibrio spp., and Pseudomonas aeruginosa, contributing to sustainable disease management with minimal environmental impact. It can be suggested that bacteriocins may play an essential role in combating pathogens and offer viable alternatives to conventional antibiotics across primary food production systems, though optimization of production methods and regulatory frameworks remains essential for broader commercial adoption. Full article