Search Results (1,038)

Background/Objectives: The limited aqueous solubility of therapeutically active drugs remains a significant challenge in their pharmaceutical application. This study presents a novel solid dispersion matrix (NSDM) that utilizes the inverted thermoresponsive behavior of Pluronic F127 to enhance drug dissolution while addressing the industrial and ecological limitations of conventional methods. Methods: For comparative assessment, a solid dispersion formulation of dapagliflozin was formulated using the NSDM approach and three conventional approaches: heat fusion (HFSD), microwave (MWSD), and lyophilization (LPSD). Differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD) were used to characterize the prepared formulations. In vitro dissolution test was performed to compare the pharmaceutical performance of NSDM against conventional approaches. Results: The NSDM exhibited a unique thermal transition to the liquid state at 32.4 °C. Moreover, the physiological assessment revealed complete liquefaction within 81.7 s. DSC and XRD confirmed amorphization of dapagliflozin in all formulations. In addition, FTIR revealed that dapagliflozin was integrated within the formulation without any chemical interaction with the excipient. Dissolution studies showed remarkable superiority of NSDM, with 97.30 ± 2.26% dissolution efficiency and a mean dissolution time of 2.40 ± 0.80 min. A multi-criteria assessment of ecological impact, worker friendliness, industrial effectiveness, and pharmaceutical performance demonstrated NSDM’s comprehensive advantages. Conclusions: The present approach provides a sustainable paradigm compared to conventional solid dispersion approaches. It eliminates energy-intensive operations and post-processing steps through direct capsule filling. This affords superior pharmaceutical performance while supporting sustainability and industrial applicability. Full article

Cell encapsulation within semipermeable membranes is a promising strategy for protecting transplanted cells from host immune responses, while permitting the diffusion of nutrients and therapeutic molecules. Although alginate-based microcapsules are commonly used, ionically crosslinked capsules often exhibit limited structural stability and tunability in terms of membrane permeability. In this study, we developed covalently stabilized microcapsules. Alginate microgel beads were first prepared as sacrificial templates and subsequently coated with phenol-modified chitosan and hyaluronic acid (Chitosan–Ph and HA-Ph) via layer-by-layer assembly. The multilayer membrane was then covalently stabilized through horseradish peroxidase (HRP)-mediated oxidative coupling of phenol groups, followed by liquefaction of the alginate core. The crosslinked microcapsules maintained structural integrity after liquefaction, while markedly reducing γ-globulin permeation under in vitro conditions and preserving β-cell viability and glucose responsiveness. The findings of this study demonstrate the feasibility of this system as an in vitro platform for stable cell encapsulation, with potential relevance to cell therapy. Full article

This study presents a structural integrity evaluation of a 5000 m³ IMO Type C independent tank designed for storing liquefied carbon dioxide (LCO₂) at −35 °C and 15 barg, based on the IMO IGC Code and Korean Register (KR) rules. A finite element model was developed to assess structural responses under representative load cases considering thermal contraction, internal pressure, and ship-induced accelerations. The results show that structural design is predominantly governed by the internal pressure associated with liquefaction conditions and boil-off gas (BOG) accumulation, rather than the minimum design pressure specified by classification rules or liquid head pressure. As a result, the required tank thickness approaches the upper practical limit (approximately 50 mm), leading to inherently sufficient buckling resistance without additional design constraints. These findings indicate that, under medium-pressure LCO₂ storage conditions, Type C tank design is primarily pressure-driven, and structural stability can be effectively ensured through thickness design. The study provides practical insights into governing design factors for rule-based tank design and highlights key considerations for LCO₂ storage applications. Full article

During the marine transport of liquid hydrogen, heat ingress leads to the generation of boil-off gas (BOG), which increases the pressure in the liquid hydrogen storage tanks. Effective BOG management is therefore essential to ensure tank safety and minimize hydrogen loss. This study develops a cryogenic compression recovery and storage system for BOG generated during the marine transport of 160,000 m³ liquid hydrogen. The core process involves compressing a portion of the BOG and subsequently utilizing the BOG’s inherent cold energy to cool the compressed hydrogen, ultimately enabling the storage of the final cryogenic compressed hydrogen product. ASPEN-PLUS software was employed to analyze the proposed system’s specific energy consumption (SEC) and ψ (hydrogen density/SEC) for producing cryogenic compressed hydrogen (CcH₂) across a temperature range of 53 to 110 K and a pressure range of 40 to 100 MPa. Seven optimal sets of state parameters were identified for the cryogenic compressed hydrogen product. Based on a specified optimal parameter set of 80 K and 50 MPa, a simulation of the proposed system’s performance yielded a SEC of 2.25 kWh/kg CcH₂ and an exergy efficiency of 87.88% with BOG feed at 53 K and 0.1 MPa, along with the exergy loss and exergy efficiency for each component. Compared to a BOG re-liquefaction system and a MRJT CcH₂ system under identical conditions, the proposed system achieves 31.81% and 64.9% reduction, respectively, in SEC and 17.32% and 94.6% improvement, respectively, in exergy efficiency. Furthermore, the effects of feed temperature and cryogenic compressed hydrogen product mass flow rate on the proposed system’s SEC and exergy efficiency were investigated. Full article

The escalating global challenge of waste management, combined with the urgent need to reduce greenhouse gas emissions, has intensified interest in waste-to-energy (WtE) technologies as integrated solutions for sustainable energy recovery. This review critically examines advanced WtE technologies through three interconnected dimensions: the strength of the evidence base supporting performance and environmental claims, the challenges associated with scalability and system integration, and the implications of these technologies for net-zero energy transitions. The analysis covers thermochemical, biochemical, and hybrid conversion pathways, including pyrolysis, gasification, hydrothermal liquefaction, and anaerobic digestion, with particular emphasis on identifying inconsistencies in the literature and clarifying key uncertainties. A persistent gap between laboratory-scale performance and commercial-scale operation is identified and characterised across conversion pathways. Its principal drivers of feedstock heterogeneity, heat transfer limitations, and operational complexity are examined. Environmental assessments are shown to be highly sensitive to system boundary definitions and carbon accounting methodologies, with lifecycle results varying substantially depending on energy substitution assumptions and biogenic carbon treatment. The integration of WtE within circular economy frameworks demonstrates that energy recovery is most effective when positioned as a complement to material recycling rather than a substitute. The roles of combined heat and power configurations, district heating, carbon capture and storage, and emerging reactor technologies in advancing net-zero contributions are assessed. Significant data gaps are identified in long-term operational performance, modelling transparency, and reporting standardisation. The review concludes that WtE technologies represent valuable components of integrated waste and energy management systems, but their long-term contribution to decarbonisation requires careful system design, sound operational strategies, and harmonised performance evaluation frameworks. Full article

Thermochemical/catalytic co-processing of biomass and solid wastes is a promising route for waste valorization, low-carbon energy recovery, and the co-production of fuels, chemicals, and carbon materials. Conventional pathways, including pyrolysis, gasification, liquefaction, and carbonization, provide the basic framework for mixed-feed conversion. Emerging routes, such as flash Joule heating, microwave-assisted conversion, plasma processing, supercritical water treatment, solar-driven systems, and machine-learning-assisted optimization, further expand opportunities for process intensification and selective upgrading. Owing to feedstock complementarity, including hydrogen donation from plastics, catalytic effects of ash minerals, and interactions among reactive intermediates, co-processing can enhance deoxygenation, hydrogen generation, aromatization, and carbon utilization. Major challenges remain, however, including feedstock heterogeneity, reactor scale-up, catalyst stability, and the limited transferability of laboratory-scale synergy to realistic waste streams. Future progress should therefore focus on continuous validation, mechanistic clarification, and integrated techno-economic, life-cycle, and data-driven assessments. Full article

Tailings management presents a critical challenge for the mining industry, particularly in mountainous regions with high seismicity and steep slopes. This article presents the development and design criteria for dry stacking of filtered tailings as a sustainable and safe alternative to conventional slurry tailings storage facilities (TSFs). The study focuses on the extreme conditions of a mountainous location characterized by complex topography with 10% slopes, space constraints, and significant seismic activity defined by a peak ground acceleration (PGA) of 0.3 g. The design methodology, which incorporates layered compaction of the filtered tailings to achieve a geotechnically stable structure, is detailed for a filtered TSF consisting of 7 terraces, each 10 m high, reaching a total height of 70 m. This approach minimizes the risk of liquefaction and prepares the filtered tailings surface for progressive closure, with unit operating costs (OPEX) of 2.5 USD/t. The results of the physical stability analysis confirm the viability of this solution: pseudo-static stability analysis yielded a safety factor of 1.22, demonstrating a significant reduction in water consumption and potential environmental impact. It is concluded that the dry disposal of filtered tailings is a technically robust option for tailings management in extreme mountainous environments, offering greater long-term safety guarantees and facilitating landscape integration, thus setting a precedent for mining projects in similar geographies. Full article

Onboard carbon capture and storage (OCCS) is promising, but downstream CO₂ conditioning and liquefaction dominate energy and operability constraints. An integrated OCCS onboard for CO₂ conditioning, deep cooling, phase separation and liquid CO₂ (LCO₂) storage for a dual-fuel marine engine was introduced and investigated. In addition, the proposed system has been scrutinized under Aspen HYSYS V12.1 steady state mode and a comprehensive sensitivity sweep on deep-cooler temperature and separation pressure. Sensitivity sweeps reveal a sharp liquefaction threshold governed by the deep-cooler outlet temperature. For the engine load range from 50% to 110% and exhaust gas from 1.288 to 2.863 kg/s with CO₂ from 3.65 to 6.67%, the model is validated at 90.3% capture. Near vent-free operation for T_E105 < −24.58 °C, and a P-T diagram indicates that near vent-free operation requires P_V105 > 190 kPa at −24.7 °C, while −22.45 °C is unattainable within 1600–2200 kPa. Increasing compressor discharge pressure from 1500 to 2500 kPa raises compression power from 34.8 to 80.23 kW at −21 °C without improving vent/yield under throttled control. By identifying threshold-based deep-cooling setpoints, creating a separator pressure-temperature feasibility envelope for near-vent-free operation, and clearly quantifying CO₂-rich vent slip as a system-level loss term, this study offers an operability-driven design layer for onboard CO₂ liquefaction. Full article

Waste-to-energy technology plays a crucial role in advancing the circular economy framework, a strategy that contributes to achieving the United Nations Sustainable Development Goals on responsible consumption and production, as well as the provision of affordable and clean energy. Hydrothermal co-liquefaction has emerged as a promising technology for addressing waste material challenges by converting them into valuable biofuels. This review focuses on biomass feedstock classification and provides an overview of hydrothermal co-liquefaction for sustainable waste management and improved energy production. Moreover, the article provides details on integrating other waste treatment methods with hydrothermal liquefaction to promote the circular economy. Research publications from 2015 to 2025 were obtained from Web of Science and Scopus to identify research trends and output across countries and map out future research directions. The retrieved data from Web of Science was analysed for mapping research, keyword occurrence, and network analysis using VOSviewer software. The study highlighted that waste treatment techniques not only mitigate environmental pollution but also provide a sustainable pathway for energy production and contribute to global carbon neutrality. The review shows that biocrude yield varies with blending ratio because of differences in the biochemical composition of feedstocks, which affect reaction pathways and lead to synergistic or antagonistic interactions during co-processing. Therefore, careful selection of biomass feedstock is essential to achieve optimal results. Full article

Microbially induced desaturation and precipitation (MIDP) is a promising eco-friendly technique for liquefaction mitigation. However, existing studies have primarily focused on silica sands under element-scale cyclic loading, and the dynamic response of MIDP-treated marine sand under seismic excitation remains poorly understood. In this study, the denitrifying bacterium Pseudomonas stutzeri was used to generate nitrogen gas in situ within typical liquefiable marine sand from the Haikou Jiangdong New Area, producing treated specimens with degrees of saturation ranging from approximately 99% to 80%. Shaking table tests were performed under Wenchuan earthquake motions with peak ground accelerations of 0.10–0.20 g. The results show that reducing the degree of saturation by approximately 18.9% decreases surface settlement by 77.6%, while the peak pore water pressure and lateral displacement are reduced by 21% and 15%, respectively. The acceleration response of the treated specimens also exhibits a notable attenuation effect. These findings provide preliminary comparative experimental evidence for the application of MIDP in the eco-friendly liquefaction mitigation of coastal marine sand foundations. Full article

This research provides an extensive evaluation of liquefaction induced by earthquakes in the Ionian Islands, specifically Lefkada, Cephalonia, Ithaki, and Zakynthos, through the compilation of a liquefaction inventory and GIS-based liquefaction susceptibility index (LiSI) maps. A total of 49 liquefaction sites from 20 causative earthquakes confirm that liquefaction is a recurrent geohazard in the area, primarily affecting coastal and low-lying areas with unconsolidated post-alpine deposits. The relationship between earthquake magnitude and maximum epicentral distance of observed liquefaction is consistent with global empirical datasets, indicating that moderate to strong earthquakes (M_w = 5.9–7.4) can induce liquefaction at considerable distances. The susceptibility model integrates eleven conditioning variables, classified as geological and geomorphological variables, hydrological indices and optical satellite imagery-derived data, within an analytic hierarchy process (AHP) framework. Lithology, age, and geomorphological unit emerged as the dominant conditioning variables. The LiSI maps confirm the zones previously identified in the inventory. Model validation and sensitivity analysis including confusion matrix components, key performance metrics and ROC analysis in coarser grid sizes demonstrate performance ranging from excellent (Zakynthos) to moderate (Lefkada and Cephalonia), while remaining inconclusive for Ithaki due to data limitations. The model exhibits generally conservative behavior, characterized by high precision and specificity but variable sensitivity, while it is largely stable across spatial resolutions in most cases. Full article

The conversion of lignocellulosic biomass into bio-polyols through liquefaction has attracted increasing interest as a sustainable route for polymer feedstock production. The liquefaction of Ruscus aculeatus L. branches was investigated to identify optimal processing conditions and to evaluate the properties of the resulting bio-polyols. The effects of temperature, reaction time, particle size, and material-to-solvent ratio on liquefaction yield were systematically studied. Liquefaction yield increased markedly with temperature, reaching up to 92% at 180 °C after 60 min of reaction, while reaction time showed only a marginal effect beyond 15 min. Smaller particle sizes and higher solvent ratios improved liquefaction efficiency, with optimal conditions identified between 1:7 and 1:10 material-to-solvent ratios. The hydroxyl number decreases with increasing liquefaction temperature due to dehydration and condensation reactions. Thermal and rheological analyses indicated improved thermal stability and increased viscosity at higher liquefaction temperatures. These results highlight the potential of Ruscus aculeatus branches as a promising renewable feedstock for bio-polyol production and polyurethane applications. Full article

Predicting the settlement behavior of jet-grout column groups in reclaimed coastal areas remains a significant geotechnical challenge, as conventional models do not capture the complex interaction between isolated stiff columns and the compliance of the composite system under wide-area loading. This study presents a field-calibrated analytical approach that reconciles single-column mechanics with full-scale group performance at a port terminal founded on highly compressible, liquefaction-prone marine backfill improved by 800 mm jet-grout columns. An extensive field-testing program—including cone penetration tests (CPTs), single-column load tests (SCLTs), and surface loading tests (SLTs)—was conducted. SCLT results revealed an elastic modulus exceeding 10 GPa, and CPT data confirmed up to a 250% increase in inter-column soil tip resistance. However, SLTs under an 85 kPa operational load yielded a back-calculated system stiffness of approximately 105 MPa, which is drastically lower than the theoretical unit cell prediction of 933 MPa. This empirical relation demonstrates that unit cell models fundamentally overestimate jet-grout group stiffness. Rather than proposing a site-specific static mobilization factor (β ≈ 0.11), this study introduces a novel, adaptive methodology. By systematically integrating single-column rigidity, group interaction, and stress transfer mechanics into untreated soil, this framework establishes a robust paradigm for accurately predicting composite stiffness and settlements across diverse geotechnical conditions. Full article

This study proposes a CO₂ re-liquefaction system utilizing the cold energy of LNG and liquid hydrogen (LH₂) to efficiently manage boil-off gas in alternative fuel-based CO₂ carriers. Process simulations using Aspen HYSYS V11 under 100% and 70% propulsion loads evaluated the Specific Energy Consumption (SEC), Coefficient of Performance (COP), UA of heat exchangers, and Specific Life Cycle Cost (SLCC). The results demonstrate that under both 100% and 70% propulsion load conditions, the utilization of cold energy decreases the SEC by 24.5% and improves the COP by approximately 34% compared to the reference model without cold energy utilization. Sensitivity analysis on the minimum temperature approach indicates limited impact on performance. The UA of the heat exchangers decreased by up to 83% (LNG) and 87% (LH₂), offering significant downsizing advantages. Economically, SLCC was reduced by up to 14.8% and 15.9% for the LNG and H₂ models, respectively, due to lower Capital Expenditure (CAPEX) and Operating Expenditure (OPEX). Consequently, this study demonstrates that exploiting the cold energy of alternative fuels significantly improves both the thermodynamic performance and economic feasibility of CO₂ re-liquefaction systems, providing foundational data for future optimization. Full article

The deformation of surrounding soil primarily governs the behavior of underground structures. Consequently, variations in their external geometry significantly affect their overall seismic response. Moreover, large soil deformations and structural uplift caused by liquefaction severely threaten their seismic safety. While most previous studies have focused on conventional rectangular subway stations, the seismic performance of novel varying-span structures remains largely unexplored. In this study, nonlinear dynamic time-history analyses are conducted to investigate the soil–structure interaction (SSI) of large unequal-span subway stations in liquefiable sites. Furthermore, the seismic responses of both the structure and the surrounding soil are systematically evaluated under various burial depths of the liquefiable layer. Finally, a U-shaped foundation reinforcement method is proposed to mitigate structural uplift. The results show that unequal-span structures suppress liquefaction in lateral soil, whereas significant liquefaction occurs beneath the base slab and cantilevered middle slabs. The burial depth of the liquefiable layer has a negligible effect on the liquefaction state directly under the center span. Regarding structural response, global uplift follows a spatial pattern that peaks at the center span and gradually attenuates laterally. Although the proposed U-shaped reinforcement effectively reduces both total and differential uplift, it does not fundamentally change the underlying liquefaction mechanism. Specifically, reinforcing the soil under cantilevered sections minimizes differential uplift while enhancing the overall economic efficiency of the seismic design. These findings provide a scientific basis for optimizing the seismic resilience of complex underground structures, contributing to the development of resource-efficient and disaster-resilient urban underground infrastructure in liquefaction-prone regions. Full article