Search Results (202)

Prompt specifications for multi-agent large language model (LLM) systems carry data contracts and integration logic across interdependent files but are rarely subjected to structured-inspection rigor. We report a single-system case study of iterative, agent-driven auditing applied to AEGIS (Autonomous Engineering Governance and Intelligence System), a seven-lane production pipeline whose 7152-line specification surface was audited across nine rounds, surfacing 51 consistency defects (per-round counts of 15, 8, 12, 2, 8, 1, 4, 1, 0). We present a seven-category post hoc taxonomy with explicit coding rules, non-monotonic convergence consistent with cascading edits and audit-scope expansion, and a locked audit protocol. We further report two partial replications on a public synthetic mini-specification: a cross-LLM panel of four frontier vendors (OpenAI, Anthropic, Google, xAI; 12 traces; multi-vendor union detects all five seeded defects) and an inter-rater reliability check on a stratified subsample (Cohen’s $\kappa$ = 0.80 on category, 0.46 on severity). The full reproducibility bundle accompanies the submission. Full article

The Kelch-repeat superfamily genes played important roles in regulating plant growth and development; however, their functions in foxtail millet (Setaria italica) have not yet been characterized. In this study, SiNL4, a homolog of ZmNL4 controlling leaf width in maize, was knocked out using the CRISPR/Cas9 technology, and two homozygous knockout lines (ko1 and ko2) were obtained. Phenotypic analysis showed that compared with the wild-type Ci846, ko1 and ko2 exhibited reduced leaf width and decreased yield related traits (e.g., panicle weight, grain width, and 1000-grain weight). Cytological analysis showed that changes in leaf width of ko1 and ko2 resulted from a decrease in leaf epidermal cell width and the number of small vascular bundles (SVBs) close to the leaf edge, suggesting that SiNL4 might regulate leaf width by influencing cell expansion and the development of SVB. Spatiotemporal expression analysis indicated that the relative expression level of SiNL4 was high in the stem, leaf, and young panicle. Subcellular localization showed that SiNL4 was mainly localized in the mitochondria and plasma membrane. In addition, the T-DNA insertion mutant (Atnl4) of AT5G18590, the ortholog of SiNL4 in Arabidopsis thaliana, exhibited similar phenotypes with reduced rosette leaf width, seed width, and 1000-seed weight. Moreover, complementary expression of SiNL4 in Atnl4 not only restored the phenotypes, but also significantly increased the 1000-seed weight, indicating that the function of these two genes might be conserved. Meanwhile, we found that SiNL4 knockout caused a decrease in chlorophyll content and net photosynthetic rate (Pn), showing that SiNL4 might be involved in regulating photosynthesis. In summary, this study revealed the function of SiNL4 in regulating leaf width in foxtail millet, providing a potential gene for the genetic improvement of foxtail millet. Full article

The region of Xilingol League in Inner Mongolia exhibits typical sustained wind characteristics. To reveal the typical flow field behavior of transmission line conductors in sustained wind regions, this study takes the Xilingol League area as the research subject. First, based on regional meteorological data and investigations of transmission line, the characteristics of the sustained wind and typical conductor are analyzed. Two representative conductors, JLB40-120 and JL/G1A-400/35, are selected for the study. On this basis, two-dimensional numerical models of an actual stranded conductor cross-section and an equivalent smooth circular cylinder are established to conduct a comparative analysis of flow separation, wake evolution, Kármán vortex street formation, and pressure distribution characteristics for both a single conductor and a twin-bundled conductor under sustained wind. Furthermore, a three-dimensional flow field model is constructed to investigate the characteristics of streamline around the conductor and the spatial distribution of surface pressure. The results indicate that, compared to a single conductor structure, the twin-bundled conductor structure exhibits more significant wake interference between sub-conductors, resulting in more complex wake structures and pressure distributions. Compared with the equivalent smooth circular cylinder, the actual stranded conductor cross-section, due to its surface geometric irregularities and structural details, is more prone to inducing early boundary layer separation, leading to more complex wake evolution and asymmetric vortex shedding. The three-dimensional model further reveals that the flow around the conductor exhibits pronounced spatial characteristics, with both the wake vortex structures and surface pressure distribution showing non-uniform three-dimensional features. The results provide a reference for the analysis of wind-induced vibration mechanisms of transmission lines and the optimization of related structural designs under sustained wind conditions. Full article

For high-voltage power transmission, the surface voltage gradient (SVG) of the conductor plays a crucial role in meeting corona performance requirements. The SVG is greatly impacted by the smoothness of the conductor’s surface. Under identical conditions, the SVG of smooth, round conductors differs from that of stranded conductors with the same outer radius. This paper uses Finite Element Analysis (FEA) to study the effect of different stranded conductor geometries and three-phase line topologies with stranded conductor bundles on the SVG. Although industry standards and the scientific literature often rely on simplified smooth-cylinder approximations, this research demonstrates that surface irregularities significantly increase electrical stress compared to idealized smooth surfaces. Through simulating various three-phase configurations, the study reveals a nearly constant field enhancement factor across diverse stranded designs. These results enable us to apply formulas developed for smooth conductors to more realistic power line applications involving stranded conductor bundles. Consequently, this FEA approach offers engineers a precise, versatile method for designing high-voltage transmission lines. The findings presented here facilitate a deeper understanding of the SVG surrounding stranded conductors, particularly with regard to its influence on corona phenomena. Full article

Background/Objectives: We developed a telehealth-enabled fiber-bundle endomicroscopy platform and evaluated its preclinical feasibility for targeted fluorescence imaging in cervical cancer models. Methods: The platform integrates a portable fiber-bundle endomicroscopy (FBE) system, fluorescein isothiocyanate (FITC)-labeled candidate peptides, and a secure web-based telehealth platform for remote consultation. The FBE probe achieved a field of view of 1,700 µm and a lateral resolution of 4 µm, enabling cellular-level fluorescence imaging in a compact, portable format. Four FITC-labeled peptides (SHS1*, SHS2*, FPP*, and CRL*) were evaluated in A549, SiHa, and CaSki cell lines. Ex vivo testing was performed on commercial cervical tissue-array samples. The telehealth platform was assessed for secure medical-image/video transmission and end-to-end latency in a simulated remote-consultation setting. Results: Among the tested probes, FPP*-FITC and CRL*-FITC showed higher fluorescence-positive fractions in the p16-overexpressing cervical cancer cell lines than in the A549 comparator line, with the strongest signals observed in CaSki cells. In ex vivo testing, CRL*-FITC generated higher fluorescence intensity in malignant cervical tissue-array samples than in non-malignant comparator tissues, with a reported 4.6- to 7.4-fold difference in mean signal intensity (p < 0.001). The telehealth platform supported the secure transmission of medical images and video and demonstrated an end-to-end latency of <500 ms in a simulated remote consultation setting. Conclusions: These results support the technical and preclinical feasibility of integrating targeted fluorescence imaging, portable fiber-bundle endomicroscopy, and telehealth into a single platform. This study should therefore be interpreted as a preclinical feasibility study evaluating optical, molecular, and telehealth integration, rather than as a clinically validated cervical cancer screening test. Full article

Introduction: Work engagement among nurse case managers is central to safe, efficient, person-centred care, yet organisational and team-level factors that support engagement or mitigate burnout remain poorly synthesised. Aim: To map organisational and team-level strategies that enhance work engagement or reduce burnout among nurse case managers and aligned roles, as well as to consider their applicability to Gulf health systems. Method: We conducted a scoping review in accordance with the Arksey and O’Malley framework as refined by Levac et al. and reported it in line with PRISMA-ScR and PRISMA-S guidance. Six databases and targeted sources were searched for English-language records published between 2015 and 2025. Two reviewers independently screened titles/abstracts and full texts against predefined eligibility criteria, charted data using a piloted form, and synthesised findings thematically against Job Demands–Resources (JD-R) domains. Results: Of 303 records identified, 248 were screened after deduplication, and 11 studies were included. Across nine health systems, findings were mapped to three JD-R domains: job resources, job demands, and personal resources. The most recurrent resource-related strategies involved structural supports, staffing stability, coordination infrastructure, and supportive leadership or team practices. Key demands included role complexity, high caseloads, coordination workload, discharge pressures, and staffing instability. Personal-resource approaches were fewer and mainly involved stress management, communication, and reflective practice interventions. Engagement was infrequently measured directly, and only one empirical intervention study originated from a Gulf health system. Conclusions: This JD-R-informed scoping review suggests that strengthening structural, staffing, and coordination resources, alongside supportive leadership and team climates, may be important for sustaining engagement and limiting burnout among nurse case managers. However, these findings should be interpreted as exploratory signals that map the current evidence landscape rather than definitive evidence of effectiveness. Multi-component JD-R-informed bundles in Gulf region health systems should therefore be prioritised for context-sensitive co-design, piloting, and evaluation. Full article

To accurately evaluate the electric and magnetic field distribution characteristics around transmission lines under different tower structures and operating conditions, this study systematically investigates the spatial electric and magnetic fields of transmission line towers based on Grid Information Model (GIM) file parsing and finite element simulation. First, key information, including tower geometric configuration, conductor suspension point locations, and voltage level, is extracted by parsing the GIM file. A unified transformation method from geographic coordinates to three-dimensional Cartesian coordinates is established, and a three-dimensional electric and magnetic field calculation model is constructed in the ANSYS Maxwell platform, incorporating a catenary conductor model and an equivalent representation of bundled conductors. Furthermore, the accuracy of the proposed calculation method is validated based on field measurement data. Second, under single-circuit operating conditions, the spatial electric and magnetic field distributions of the Goblet-shaped suspension tower and the Drum-type transmission tower are analyzed under different phase sequence arrangements and different conductor-to-ground heights, and the shielding effect of the tower structure on the local electric field is investigated. On this basis, an electric field fitting method based on a proportional polynomial model is proposed, enabling the prediction of electric field distribution under tower-present conditions using simulation results obtained without tower structures. Subsequently, the influence of different phase sequence combinations on the spatial electric field distribution is systematically examined. The fitting method is further extended to double-circuit transmission lines, and its accuracy and effectiveness in rapid electric field assessment are verified. Finally, from an engineering practice perspective, the effects of the presence of jumper conductors and variations in conductor turning angles on the spatial electric field distribution of double-circuit towers are analyzed, and an optimized estimation approach for electric fields under different turning angle conditions is proposed. The results demonstrate that tower structural configuration and conductor arrangement significantly affect the electric field distribution, and the proposed fitting method effectively reduces modeling complexity while maintaining computational accuracy. The findings of this study provide a theoretical basis and technical reference for electric and magnetic environment assessment and engineering design of transmission lines. Full article

Background/Objective: Advances in intensive care medicine have substantially improved the survival of critically ill patients; however, they have also revealed the growing burden of neurological complications that affect both short-term outcomes and long-term functioning. Neurological complications in the intensive care unit (ICU) include a wide spectrum of disorders, ranging from acute brain dysfunction such as delirium, coma, and encephalopathy to persistent cognitive impairment after discharge, which represents a key component of Post-Intensive Care Syndrome (PICS). Delirium affects approximately one-third of ICU patients and is independently associated with increased mortality, prolonged hospitalization, and worse long-term neurocognitive outcomes. Due to the limited effectiveness of pharmacological therapies, current clinical approaches emphasize prevention, early diagnosis, and non-pharmacological strategies in line with PADIS guidelines. This narrative review aims to provide a clinically relevant synthesis of neurological complications in adult ICU patients, conceptualized as a continuum from acute brain dysfunction to long-term cognitive impairment. Methods: A narrative review of the literature was conducted, focusing on studies addressing epidemiology, pathophysiology, risk factors, diagnostic strategies, and prevention of neurological complications in critically ill adults. Attention was given to delirium, ICU-acquired cognitive impairment, and their association with PICS, as well as to current guideline-based and non-pharmacological interventions. Results: Available evidence indicates that neurological complications in the ICU are multifactorial and result from the interaction between patient vulnerability, severity of illness, systemic inflammation, sedative exposure, and environmental factors. Delirium remains the most common manifestation of acute brain dysfunction and is strongly associated with adverse outcomes. Increasing evidence supports the effectiveness of structured screening, early mobilization, sleep optimization, and multidisciplinary care bundles in reducing delirium incidence and duration. Moreover, growing attention is directed toward post-ICU follow-up and rehabilitation to reduce long-term cognitive decline. Conclusions: Neurological complications should be considered a central component of critical illness and a continuum extending beyond ICU discharge. Early identification of high-risk patients, implementation of preventive strategies, and integration of acute and post-ICU care are essential to improve survival and long-term cognitive outcomes. Further research should focus on personalized preventive and neuroprotective approaches in critically ill patients. Full article

To address the low efficiency of finite element modeling and the reliance on manual measurements in electric/magnetic field analysis of complex overhead transmission line structures, this paper develops an IronPython-based automated computational platform within ANSYS Maxwell for 3-D modeling and electric/magnetic field analysis. First, by parsing transmission line data from the Grid Information Model (GIM), a unified coordinate transformation method is proposed to convert geographical coordinates into three-dimensional (3-D) Cartesian coordinates for finite element analysis. Based on the extracted line parameters, conductor sag is calculated and catenary modeling is implemented. An equivalent radius method is also introduced to simplify multi-bundle conductor modeling, enabling fast parametric construction of complex 3-D transmission line models. Second, by combining the IronPython scripting language with the .NET Windows Forms control library, a visualized finite element modeling and computation platform is developed. Finally, a typical double-circuit transmission line on the same tower is taken as a case study to calculate the spatial distribution of electric/magnetic fields. The influence of solution domain size on electric/magnetic field computation results is investigated, and optimal solution domain parameters are determined. The finite element results generated by the developed platform are further validated through comparison with measured data. The results demonstrate good agreement between calculated and measured values, confirming the accuracy and engineering applicability of the developed platform for electric/magnetic environment analysis of overhead transmission lines. Full article

Gibson’s concept of optic flow established that perception is grounded in lawful structure generated by action. However, no formal mechanical framework has described the invariant structure of action-generated kinesthetic information during skilled manipulation. This study introduces haptic flow as a screw-theoretic invariant defined by the coupled rotational–translational organization of a body–object system. Motion capture data from a two-case comparison (one proficient and one novice golfer) were analyzed using instantaneous screw axes (ISA), pitch evolution, and cylindroid geometry derived from a linear line-complex formulation. The proficient golfer exhibited (1) progressive convergence of ISAs toward a coherent bundle, (2) stabilization of screw pitch through impact, and (3) co-cylindrical alignment of harmonic screws consistent with inertial–restoring conjugacy. In contrast, the novice golfer showed fragmented ISA organization and elevated pitch variability. These differences were descriptive rather than inferential and do not imply population-level generalization. The findings suggest that skilled manipulation is characterized by stabilization of symmetry-bearing screw invariants rather than by independent joint control. Interpreted ecologically, haptic flow is proposed as a mechanically specified candidate invariant generated by lawful body–object coupling. The present study establishes a geometric framework for quantifying such invariants while identifying the need for cross-task and perceptual validation. Full article

Using the instanton partition function for five-dimensional $U\left(1\right)$ gauge theory with eight supercharges and a single adjoint massive hypermultiplet on the $\Omega$ background, we give explicit expression for non-perturbative corrections to the topological string theory in the holomorphic limit. It was argued that in this case the theory is compactified on the twisted affine line bundle over $\mathbb{C}\times T^2$. We perform calculations in two ways. First we modify the integration contour by adding poles responsible for non-perturbative physics in accordance with a recent proposal. Then, we compute the genus zero Gopakumar–Vafa invariants for our case and evaluate the non-perturbative corrections to the partition function. We check that both calculations give the same result. Full article

Overhead transmission lines are critical carriers for power delivery, directly influencing the security of the power system. In high-altitude areas, special environmental conditions such as low air pressure and intense solar radiation significantly change the heat absorption and dissipation characteristics of conductors. Therefore, it is necessary to correct the overhead conductors’ ampacity in such areas to ensure safe operation. However, the ampacity calculation method and high-altitude ampacity correction coefficients proposed in existing standards have significant limitations, and there are also large errors in the calculation results. Therefore, based on the system of partial differential equations proposed in the “Guidelines for Calculating the Current-Carrying Capacity of Transmission Conductors at High Altitudes” and the suggestions for high-altitude meteorological parameter modifications from existing standards, this paper establishes a three-dimensional finite element model to study the ampacity calculation method for overhead conductors in high-altitude areas. The results show that a significant thermal shielding effect exists among bundled conductors, and meteorological condition variations significantly influence the temperature distribution of the conductors and their surrounding space. At altitudes of 4000~5000 m, the altitude correction coefficient for both twin-bundle and quad-bundle conductors is −0.06 A∙m⁻¹ under specific conservative conditions. Full article

Lean implementations often deploy tools in isolation, leaving gaps in how abnormalities are exposed, resolved at the root cause, escalated when needed, and converted into organisational learning. This study proposes a five-stage closed-loop routine for daily factory management that integrates problem visibility, standardised shop-floor cadence, disciplined problem-solving, and tiered escalation within a single operating logic. The novelty lies not in the individual Lean tools, but in the specification of cadence, triggers, accountable roles, and verification steps that connect them into a replicable end-to-end routine. The model was evaluated through a 19-month longitudinal, single-site field intervention (quasi-experimental before–and–after) on the bottleneck production line of a pharmaceutical plant in Hengoed, Wales (UK). Line OEE increased by over 50% in relative terms. At factory level, total output increased by 20% year-on-year in 2024 (context indicator), alongside qualitative field observations of shorter time-to-resolution and improved cross-functional coordination. As a single-site study, external validity is context-dependent; nevertheless, the paper provides a specified closed-loop routine and field evidence on the operational effects of embedding an integrated Lean cycle into daily management. Practically, the study provides a specified routine that practitioners can replicate and adapt; academically, it contributes to Lean implementation research by showing how tool bundles can be operationalised as an end-to-end daily management routine with observable performance effects. Full article

This paper presents a real-time quarry truck monitoring system that combines deep learning and license plate recognition (LPR) for operational monitoring and weighbridge reconciliation. Rather than estimating load volumes directly from imagery, the system ensures auditable matching between detected trucks and official weight records. Deployed at quarry checkpoints, fixed cameras stream to an edge stack that performs truck detection, line-crossing counts, and per-frame plate Optical Character Recognition (OCR); a temporal voting and format-constrained post-processing step consolidates plate strings for registry matching. The system exposes a dashboard with auditable session bundles (model/version hashes, Region of Interest (ROI)/line geometry, thresholds, logs) to ensure replay and traceability between offline evaluation and live operations. We evaluate detection (precision, recall, mAP@0.5, and mAP@0.5:0.95), tracking (ID metrics), and (LPR) usability, and we quantify operational validity by reconciling estimated shift-level tonnage T against weighbridge tonnage T* using Mean Absolute Error (MAE), Mean Absolute Percentage Error (MAPE), R², and Bland–Altman analysis. Results show stable convergence of the detection models, reliable plate usability under varied optics (day, dusk, night, and dust), low-latency processing suitable for commodity hardware, and close agreement with weighbridge references at the shift level. The study demonstrates that vision-based counting coupled with plate linkage can provide regulator-ready KPIs and auditable evidence for production control in quarry operations. Full article

Background: Dedicated bundles were proven to reduce CLABSIs in a neonatal intensive care unit (NICU). Methods: We performed an observational pre–post study to evaluate the impact of a bundle for CLABSI prevention in our NICU. All umbilical vein catheters (UVCs) and epicutaneo-caval catheters (ECCs) with dwell time > 2 days were included. The primary outcome was CLABSI rate/1000 central line days. Results: A total of 145 catheters (67 UVCs and 78 ECCs) and 142 catheters (65 UVCs and 77 ECCs) were inserted before and after bundle implementation, respectively. The duration of the UVC was significantly shorter before than after the bundle [4 (3–6) vs. 8 (6–11) days; p < 0.0001], while the duration of the ECC did not differ [10 (6–17) vs. 11 (6–19) days; p = 0.711]. CLABSI were less frequent after than before bundle (3.6 vs. 10.7/1000 CL days; p = 0.042); both UVC-related and ECC-related CLABSI were significantly reduced (0 vs. 7.2/1000 CL days, p = 0.015; and 4.4 vs. 12.3/1000 CL days, p = 0.044, respectively). The Kaplan–Meier curve for ECC-related CLABSIs showed no differences between the two periods (p = 0.255), but higher survival without CLABSIs after vs. before bundle was found if considering only ECC with dwell time < 14 days (p = 0.040). Gestational age (p = 0.004) and bundle (p = 0.026) were predictive factors for CLABSIs. Non-infective complications were significantly less frequent after than before bundle (11 vs. 20%, p = 0.033). Conclusions: Our bundle reduced the overall CLABSI rate, and both UVC- and ECC-related CLABSI occurrence. The efficacy for the reduction in ECC-related CLABSIs seems limited to the first 14 days of dwell time. Full article