Search Results (401)

This study describes and validates a novel method for assessing anterior crystalline lens curvature along vertical and horizontal meridians using radial measurements derived from Scheimpflug imaging. The aim was to evaluate whether pupil diameter (PD), anterior lens curvature, and anterior chamber depth (ACD) change during accommodation and whether these changes are age-dependent. A cross-sectional study was conducted on 104 right eyes from healthy participants aged 21–62 years. Sixteen radial images per eye were acquired using the Galilei Dual Scheimpflug Placido Disk Topographer under four accommodative demands (0, 1, 3, and 5 dioptres (D)). Custom software analysed lens curvature by calculating eccentricity in both meridians. Participants were analysed as a total group and by age subgroups. Accommodative amplitude and monocular accommodative facility were inversely correlated with age. Both PD and ACD significantly decreased with higher accommodative demands and age. Relative eccentricity decreased under accommodation, indicating increased lens curvature, especially in younger participants. Significant curvature changes were detected in the horizontal meridian only, although no statistically significant differences between meridians were found overall. The vertical meridian showed slightly higher eccentricity values, suggesting that it remained less curved. By enabling detailed, meridionally stratified in vivo assessment of anterior lens curvature, this novel method provides a valuable non-invasive approach for characterizing age-related biomechanical changes during accommodation. The resulting insights enhance our understanding of presbyopia progression, particularly regarding the spatial remodelling of the anterior lens surface. Full article

This paper is about the design and fabrication of infrared lenses, which are the core components of thermal imaging cameras to be mounted on vehicles. To produce an athermalized optical system, chalcogenide glass (As₄₀Se₆₀) with a lower thermo-optic coefficient (dn/dT) than germanium was adopted as a lens material, and each lens was designed so that defocus occurs in opposite directions depending on temperature. The designed lens was fabricated using a compression molding method, and the molded lenses showed less than 1.5 μm of form error (PV) using a mold iteration process. Through evaluations of MTF and thermal images obtained from the lens module, it was judged that this optical design process is obtainable. Full article

This paper investigates the integration of Virgil Abloh’s Personal Design Language (PDL) within the broader context of architectural methodology. Through a series of workshops, architecture students and professionals engaged with Abloh’s principles to examine how subtle aesthetic and functional adjustments, grounded in artistic disciplines, can produce transformative effects on iconic 20th-century architectural forms. These workshops underscored the potential of Abloh’s interdisciplinary approach to enhance architectural discourse by introducing a novel lens through which contemporary design methodologies can be evaluated. The findings reveal that employing weighted coefficients for less commonly utilized design principles enabled novel evaluation processes, fostering creative experimentation and innovation. Additionally, this research highlights discrepancies that may arise when employing differing evaluation methodologies in the assessment of architectural work, thereby initiating a critical discussion on the public acceptance of architectural designs and the implications of varied grading frameworks in professional practice. Full article

Background/Objectives: To assess the optical performance of two refractive premium IOLs across pupil sizes and values of corneal spherical aberration (SA). Methods: Two refractive IOLs were evaluated in this study: Tecnis Eyhance and Mini Well. The surface profiles were obtained to calculate the through-object MTF (TO MTF) curves and simulate optotype images. Entrance pupil sizes ranging from 2 to 5.5 and three corneal models were analyzed in the simulation: an average population aberrated cornea, an aberration-free cornea and a post-Lasik myopic cornea. Results: For Model 1 and pupil sizes between 3.0 and 3.5 mm, Mini Well provided acceptable visual quality from far to near distances, whereas Eyhance struggled to maintain visual quality at distances closer than intermediate. For patients with lower-than-normal corneal SA (i.e., more prolate corneas, such as post-hyperopic LASIK) both IOLs exhibited a hyperopic shift in far focus. Conversely, for patients with higher-than-normal corneal SA (i.e., more oblate corneas, such as post-myopic LASIK), the shift occurred in the myopic direction. Despite the implementation of an optimized IOL power to circumvent any shift, the TO MTF nevertheless reflected the interaction between corneal and IOL SA. Furthermore, the Mini Well demonstrated increased tolerance to less negative SA values, while Eyhance exhibited behavior consistent with a monofocal lens for more positive SA values. Conclusions: Surgeons should consider each patient’s corneal asphericity and typical pupil diameter when selecting and calculating the power of the premium IOLs studied, particularly in patients with a history of refractive surgery. Full article

Background/Objectives: Biomarkers such as lens agglutinin-reactive alpha-fetoprotein and des-gamma-carboxy prothrombin, as well as biomarker- and/or clinical-parameter-derived composite models (GALAD, GAAP, ASAP, aMAP, Doylestown), may improve detection in addition to alpha-fetoprotein, yet comparative data across diverse populations remain limited. Methods: In this biobank-based case–control study, we evaluated 562 adults (120 healthy controls, 277 chronic liver disease, 165 hepatocellular carcinoma) from January 2019 to 2024. Diagnostic performance for any-stage and early-stage hepatocellular carcinoma was assessed across three thresholds: Youden-index-derived optimal cut-offs, research-established cut-offs, and cut-offs ensuring 90% specificity. Receiver operating characteristic analysis was performed. Subgroup analyses were stratified by etiology and alpha-fetoprotein status. Results: At optimal cut-offs, GALAD showed the highest sensitivity for any-stage (90.3%) and early-stage (89.1%) hepatocellular carcinoma, with 70–80% specificity. Using established cut-offs, GALAD retained the highest sensitivity for any-stage (75.8%) and early-stage (57.8%) hepatocellular carcinoma, with 93.5% specificity. GALAD demonstrated the best performance in non-viral hepatocellular carcinomas (area under the curve 0.872), whereas GAAP and ASAP showed similarly high area under the curve values in viral etiology (area under the curve 0.955–0.960). Conclusions: Our results demonstrate the consistent performance of the GALAD score across diverse populations and underscore its superiority over individual biomarkers and other composite models. Notably, the GAAP and ASAP scores—which use one less biomarker (AFP-L3)—exhibited comparable performance, particularly in viral etiology. These findings support the integration of the composite biomarker models into tailored hepatocellular carcinoma surveillance strategies. Full article

Objectives: This pre-clinical feasibility study evaluates the accuracy of a novel augmented reality-based (AR-based) guidance technology using head-mounted displays (HMDs) for the placement of patient-specific instruments (PSIs)—also referred to as surgical guides—and osteotomy performance in pelvic tumour resections. The goal is to improve PSI placement accuracy and osteotomy execution while assessing user perception and workflow efficiency. Methods: The study was conducted on ten 3D-printed pelvic phantoms derived from CT scans of cadaveric specimens. Custom PSIs were designed and printed to guide osteotomies at the supraacetabular, symphysial, and ischial regions. An AR application was developed for the HoloLens 2 HMD to display PSI location and cutting planes. The workflow included manual supraacetabular PSI placement, AR-guided placement of the other PSIs and osteotomy execution. Postoperative CT scans were analysed to measure angular and distance errors in PSI placement and osteotomies. Task times and user feedback were also recorded. Results: The mean angular deviation for PSI placement was 2.20°, with a mean distance error of 1.19 mm (95% CI: 0.86 to 1.52 mm). Osteotomies showed an overall mean angular deviation of 3.73° compared to planned cuts, all within the predefined threshold of less than 5°. AR-assisted guidance added less than two minutes per procedure. User feedback highlighted the intuitive interface and high usability, especially for visualising cutting planes. Conclusions: Integrating AR through HMDs is a feasible and accurate method for enhancing PSI placement and osteotomy performance in pelvic tumour resections. The system provides reliable guidance even in cases of PSI failure and adds minimal time to the surgical workflow while significantly improving accuracy. Further validation in cadaveric models is needed to ensure its clinical applicability. Full article

Discipline is a significant predictor of parent–child attachment and relationship quality across the lifespan. Yet, much of the research on Black families’ disciplinary strategies uses a deficit and myopic lens that focuses on punitive punishment styles (e.g., spanking or taking away privileges). In the current exploratory qualitative study, we used an intergenerational narrative lens and thematic analysis to explore semi-structured interview data from 31 Black mothers (25–60 years, M_age = 46) in the United States around their mothers’ disciplinary practices during their childhood. We explored the connections that Black adult daughters made between their childhood disciplinary practices and their current disciplinary practices with their children, as well as their current relationships with their mothers. Adult daughters varied widely in their retrospective accounts of their mothers’ disciplinary strategies, which we categorized into three themes: (a) punitive, (b) logical, and (c) natural. We also identified three themes around how their mothers’ practices informed their current disciplinary practices with their own children: namely, (d) continuity, (e) mix, and (f) shift. Finally, we identified three themes around the current nature of their mother–daughter relationships: (g) strained, (h) progressing, and (i) healthy. The results highlighted the personal and cultural factors that informed Black women’s disciplinary strategies across two generations of mothers and revealed that when adult daughters shifted away from what they experienced during childhood—it was often towards less punitive strategies. Our exploratory findings also pointed to patterns regarding the extent to which Black adult daughters felt connected, validated, and supported by their mothers. The findings lend insight into Black mother–daughter relationship dynamics, particularly around the importance of communication patterns and emotional connection in the culture of discipline within families. Full article

A double-sided telecentric zoom optical system can ensure the measurement and detection accuracy for different workpiece sizes and plays a crucial role in industrial detection. The conventional double-sided telecentric mechanical zoom system is faced with the problem of complex structure and difficult focusing. To address these issues, a liquid lens is applied to design a non-displacement double-sided telecentric zoom system in this paper. Here, the design method of the conventional double telecentric zoom system is analyzed first; then, the liquid lenses are substituted for the mechanical motion groups. Finally, a double-sided telecentric zoom system with a detection range of 25~60 mm and a magnification of −0.44×~−0.183× has been designed and optimized by Zemax software. The design results show that in the process of magnification, the root mean square radius of the diffuse spot in the system is smaller than the pixel size during the process of zooming. The modulation transfer function values at the Nyquist frequency of 80 lp/mm are all above 0.4, distortion is controlled within 0.2, and telecentricity is less than 0.5°, indicating that the system has excellent imaging quality, low distortion, and high telecentric and other characteristics, which meet system requirements. The design method proposed in this paper can provide an effective solution for the rapid conversion of displacement zoom systems to non-displacement zoom systems. Full article

This work aims to use a suitable regression model to study a count response random variable, namely, the number of citations of a research paper, that is affected by some explanatory variables. The count variable exhibits substantial variation, as the sample variance is larger than the sample mean; thus, the classical Poisson regression model seems not to be appropriate. We concentrate our attention on the negative binomial regression model, which allows the variance of each measurement to be a function of its predicted value. Nevertheless, the process of citations of papers may be divided into two parts. In the first stage, the paper has no citations, while the second part provides the intensity of the citations. A hurdle model for separating documents with citations and those without citations is considered. The dataset for empirical application consisted of 43,190 research papers in the Economics and Business field from 2014–2021, which were obtained from The Lens database. Citation counts and social attention scores for each article were gathered from the Altmetric database. The main findings indicate that both collaboration and funding have positive impacts on citation counts and reduce the likelihood of receiving zero citations. Open access (OA) via repositories (green OA) correlates with higher citation counts and a lower probability of zero citations. In contrast, OA via the publisher’s website without an explicit open license (bronze OA) is associated with higher citation counts but also with a higher probability of zero citations. In addition, open access in subscription-based journals (hybrid OA) increases citation counts, although the effect is modest. There are clear disciplinary differences, with the prestige of the journal playing a significant role in citation counts. Articles with lower expert ratings tend to be cited less frequently and are more likely to be cited zero times. Meanwhile, news and blog mentions boost citations and reduce the likelihood of receiving no citations, while policy mentions also enhance citation counts and significantly lower the risk of being cited zero times. In contrast, patent mentions have a negative impact on citations. The influence of social media varies: X/Twitter and Wikipedia mentions increase citations and reduce the likelihood of being uncited, whereas Facebook and video mentions negatively impact citation counts. Full article

Tourism’s impact on the physical environment has been discussed for almost 50 years. Tourism components, such as transport, accommodation, and consumption of activities, consume energy. However, little is known about whether particular visitor segments consume less energy, as the general focus tends to be on tourism in its entirety. Yet, some forms of tourism generate more carbon emissions than other types. Visiting Friends and Relatives (VFR) travel presents characteristics that could make it a suitable segment for destinations to consider targeting. This conceptual research article considers VFR travel through a sustainable tourism lens. This research aimed to examine the profiles and characteristics of VFR travel to understand whether and to what extent VFR travel may be a segment that has a comparatively lower impact on the environment. As a conceptual research article, it offers a theoretical foundation for empirical studies through introducing new ideas and creating a conceptual framework. Full article

The enterprise or data center does not use the M2 SATA because of the cooling problem. Therefore, SSDs employ metal cases similar to the traditional 2.5” or 3.5” hard disk. The metal case is made of aluminum, which must be ground after the metal plate forming process. Conventionally, quality control is conducted to check the ground quality of aluminum cases manually. This method is not accurate as the data are difficult to digitize. To improve the quality control, speed, and efficiency. We established a digital imaging-based inspection system for the aluminum case grinding quality control. The inspection system consists of a digital industrial camera, a closed-circuit TV lens, a light-emitting diode (LED) light source, and a personal computer. If the loading and unloading time is ignored, the test time is less than five seconds for one case. When the tested case is uploaded to the inspection system, the camera captures and sends images to the computer. The image was processed to evaluate the quality and record the tested results. Then, the tested case is classified by a robot or an operator. Full article

Dual-task paradigms that combine cognitive and motor tasks offer a valuable lens for detecting subtle impairments in cognitive and physical functioning, especially in older adults. This study used artificial neural network (ANN) modeling to predict clinical, cognitive, and psychosocial outcomes from integrated gait, speech-linguistic, demographic, physiological, and psychological data collected during single- and dual-task conditions. Forty healthy adults (ages 20–84) completed physical, cognitive, and psychosocial assessments and a dual-task walking task involving cell phone use. ANN models were optimized using hyperparameter tuning and k-fold cross-validation to predict outcomes such as the Montreal Cognitive Assessment (MOCA), Trail Making Tests (TMT A and B), Activities-Specific Balance Confidence (ABC) Scale, Geriatric Depression Scale (GDS), and measures of memory, affect, and social support. The models achieved high accuracy for MOCA (100%), ABC (80%), memory function (80%), and social support satisfaction (75%). Feature importance analyses revealed key predictors such as speech-linguistic markers and sensory impairments. First-person plural pronoun used and authenticity of internal thoughts during dual-task emerged as strong predictors of MOCA and memory. Models were less accurate for complex executive tasks like TMT A and B. These findings support the potential of ANN models for the early detection of cognitive and psychosocial changes. Full article

In recent years, the building insulation layer peeling caused by quality problems has brought about safety hazards to human life. Existing means of non-destructive testing of building insulation layers, including laser scanning, infrared thermal imaging, ultrasonic testing, acoustic emission, ground-penetrating radar, etc., are unable to simultaneously guarantee the detection depth and resolution of the insulation layer defects, not to mention high-precision imaging of the insulation layer structure. A new type of high-precision imaging radar is specifically designed for the quantitative quality inspection of external building insulation layers in this paper. The center frequency of the radar is 8800 MHz and the −10 dB bandwidth is 3100 MHz, which means it can penetrate the insulated panel not less than 48.4 mm thick and catch the reflected wave from the upper surface of the bonding mortar. When the bonding mortar is 120 mm away from the radar, the radar can achieve a lateral resolution of about 45 mm (capable of distinguishing two parties of bonding mortar with a 45 mm gap). Furthermore, an ultra-wideband high-bunching antenna is designed in this paper combining the lens and the sinusoidal antenna, taking into account the advantages of high directivity and ultra-wideband. Finally, the high-precision imaging of data collected from multiple survey lines can visually reveal the distribution of bonded mortar and the bonding area. This helps determine whether the bonding area meets construction standards and provides data support for evaluating the quality of the insulation layer. Full article

The laser pulse detection probability of a scanning direct time-of-flight light detection and ranging (LiDAR) measurement is evaluated based on the optical signal distribution on a multipixel single photon avalanche diode (SPAD) array. These detectors intrinsically suffer from dead-times after the successful detection of a single photon and, thus, allow only for limited counting statistics when multiple returning laser photons are imaged on a single pixel. By blurring the imaged laser spot, the transition from single-pixel statistics with high signal intensity to multipixel statistics with less signal intensity is examined. Specifically, a comparison is made between the boundary cases in which (i) the returning LiDAR signal is focused through optics onto a single pixel and (ii) the detection is performed without lenses using all available pixels on the sensor matrix. The omission of imaging optics reduces the overall system size and minimizes optical transfer losses, which is crucial given the limited laser emission power due to safety standards. The investigation relies on a photon rate model for interfering (background) and signal light, applied to a simulated first-photon sensor architecture. For single-shot scenarios that reflect the optimal use of the time budget in scanning LiDAR systems, the lens-less and blurred approaches can achieve comparable or even superior results to the focusing system. This highlights the potential of fully solid-state scanning LiDAR systems utilizing optical phase arrays or multidirectional laser chips. Full article

Blood samples and testing are routine in healthcare. Presently, there is a growing interest in using tear samples in place of blood. Tear samples can be obtained non-invasively and collection does not require the skills of a trained phlebotomist. Red blood cells and other cells are not present in tears, which avoids centrifugation. Importantly, basal tear samples contain most of the biomarkers present in blood. The difficulty is the small volume of basal tears, which is about 7 μL in each eye. Any contact with the eye results in additional reflex tears with a different chemical composition. The small tear samples are collected with capillary tubes and then sent out for amplified assays, such as enzyme-linked immunosorbent assay (ELISA) or polymerase chain reaction (PCR). The results are not available for several days or a week and, therefore, are less useful in an ophthalmology office. We propose the use of a contact lens that contains bound antibodies for fluorescence immunoassays. The lenses could be removed from the patient for point-of-care measurements at the bedside. To prove that this concept is possible, we performed a three-layer protein capture assay that mimics an immunoassay. For convenience, we used lysozyme (Lys), which spontaneously coats silicon hydrogel (SiHG) contact lenses (CL). Anti-lysozyme IgG was the second layer captured, with anti-lysozyme considered to be the target biomarker. The third layer was rhodamine or Alexa Fluor-labeled Ab against the IgG Fc region, considered to be the detection antibody. The multiple protein layers were stable and did not wash off the SiHG lenses. These results strongly suggest the contact lens can be used for capture immunoassays for a wide variety of biomarkers. Full article