Search Results (69)

Large-scale magnetic flux ropes (MFRs) usually become visible during an eruption and are the core structures of coronal mass ejections, but the nature of MFRs is still a mystery. Here, we identify a large transequatorial MFR that spans across NOAA 13373 (in the Northern Hemisphere) and NOAA 13374 (in the Southern Hemisphere). Here, NOAA 13373 is a growing, newly emerging active region with a leading sunspot moving rapidly to the southwest, and it is surrounded by a highly dynamic moving magnetic feature (MMF), while NOAA 13374 is a decaying active region with a tiny leading negative sunspot and a large fading area. Recurrent reconnection, which occurs under the MFRs around the leading sunspot of NOAA 13373, results in local energy release, appearing as local EUV brightening, and it is related to the appearance of a transequatorial MFR. The appearance of this MFR involves several stages: EUV brightening, the slow rising and expansion of the MFR and its hosted filament, and, eventually, fading and shrinking. These observations demonstrate that a large-scale MFR can exist for a long-term period and that MMFs play a key role in building up free energy and triggering small-scale reconnections in the lower atmosphere. The energy released by these reconnection events is insufficient for triggering the eruption of an MFR but results in local disturbances. Full article

The application of electric fields during pool boiling heat transfer has demonstrated significant potential to enhance thermal performance. However, research on boiling heat transfer enhancement under pulsed electric fields remains insufficient. To further improve pool boiling efficiency, this study systematically investigates the effects of pulsed electric fields, uniform electric fields, and electric field-free conditions on heat transfer performance using the Lattice Boltzmann Method (LBM). The results show that, compared with the uniform electric field and electric field-free condition, the pulsed electric field resulted in the smallest bubble detachment diameter and detachment period, with a higher heat flux density on the wall and the best heat transfer enhancement effect. Under the pulsed electric field, the electric force undergoes abrupt changes at the beginning and end of each pulse peak, exerting greater compression on the bubble base. Simultaneously, this leads to accelerated gas rise inside the bubble, bubble stretching, and contraction of the bottom phase boundary. There exists an optimal pulse frequency that minimizes the bubble detachment period and diameter, resulting in the best wall heat transfer enhancement effect. The effective areas for enhanced boiling heat transfer by pulsed electric fields are the bubble base and the “V”-shaped region connected to the bubble bottom. Full article

Background: Estrogen plays a crucial role in adipose tissue homeostasis, influencing fat distribution, lipid metabolism, and insulin sensitivity. Through estrogen receptor (ER) activation, particularly ERα, estradiol (E2) regulates adipogenesis, inhibits adipocyte hypertrophy, and promotes insulin signaling. It enhances lipid oxidation, reduces lipogenesis, and suppresses pro-inflammatory cytokine production, thereby maintaining metabolic health. Primary ovarian insufficiency (POI), characterized by estrogen deficiency before the age of 40, disrupts this regulatory network, leading to adverse metabolic effects. Objetives: This review examines the effects of estrogen on adipose tissue, lipid metabolism, and carbohydrate metabolism, with a particular focus on clinical evidence in women with POI. Methods: A narrative review of the metabolic alterations associated with POI, emphasizing the molecular, biochemical, and metabolic mechanisms underlying estrogen deficiency, with a special focus on adipose tissue. Results: Women with POI exhibit increased visceral fat accumulation, reduced lean mass, and alterations in adipokine secretion, resembling the metabolic phenotype of postmenopausal women. The decline in estrogen levels contributes to central adiposity, impaired lipid metabolism, and insulin resistance, exacerbating the risk of type 2 diabetes (T2D) and cardiovascular disease (CVD). The loss of estrogenic regulation leads to enhanced lipolysis in visceral fat, raising free fatty acid flux to the liver, promoting hepatic steatosis, and worsening insulin resistance. Studies indicate that POI patients have significantly higher total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides compared to age-matched controls, reinforcing their heightened CVD risk. Reduced sex hormone-binding globulin (SHBG) levels increase free androgen availability, aggravating central fat deposition. These metabolic disturbances can potentially accelerate atherosclerosis and vascular aging, increasing morbidity and mortality in POI patients. Conclusions: Understanding the role of estrogen in adipose tissue and its disruption in POI highlights the importance of early intervention. Although the available evidence is limited and largely extrapolated from menopause studies, strategies such as hormone replacement therapy, lifestyle modifications, and lipid profile optimization are essential to mitigate metabolic consequences and improve long-term health outcomes in women with POI. Full article

Resistance Element Soldering (RES) is one of the new methods of joining dissimilar materials by resistance heating using an element. Sn60Pb40 solder, which has been used for decades in tin smithing and the electrical industry, has already been tested for joining galvanized steel sheet with thermoplastic using RES. However, legal restrictions are currently moving towards prohibiting the use of lead in mass production. For this reason, the possibility of replacing Sn60Pb40 solder with Sn91Zn9 lead-free solder was verified. The results showed that with an appropriate choice of flux and resistance heating conditions, it is possible to replace Sn60Pb40 solder with Sn91Zn9 solder when joining galvanized steel sheet with thermoplastic using RES. With a suitable heat input during soldering, good conditions were achieved for wetting the base material with molten solder with a sufficient volume of remelted solder in the core of the Cu/Sn91Zn9 bimetallic element. The strength of the soldered joint made at a heat input of 901 J was measured at the level of 94% of the strength of Sn91Zn9 solder. Full article

Membrane processes are a reality in a wide range of industrial applications, and efforts to continuously enhance their performance are being pursued. The major drawbacks encountered are related to the minimization of polarization concentration, fouling, and biofouling formation. In this study, silver nanoparticles were added to the casting solutions of cellulose acetate membranes in order to obtain new hybrid membranes that present characteristics inherent to the silver nanoparticles, namely antibacterial behavior that leads to biofouling reduction. A systematic study was developed to assess the effect of ionic strength, membrane polymeric structure, and silver nanoparticle incorporation on the cellulose acetate (CA) membrane surface charge. Surface charge was quantified by streaming potential measurements and it was correlated with BSA permeation performance. CA membranes were prepared by the phase-inversion method using three casting-solution compositions, to obtain membranes with different polymeric structures (CA400-22, CA400-30, CA400-34). The nanocomposite CA/silver membranes (CA/Ag) were prepared through the incorporation of silver nanoparticles (0.1 and 0.4 wt% Ag) in the casting solutions of the membranes. To evaluate the electrolyte concentration effect on the membranes zeta potential and surface charge, two potassium chloride solutions of 1 mM and 5 mM were used, in the pH range between 4 and 9. The results show that the zeta-potential values of CA/Ag membranes were less negative when compared to the silver-free membranes, and almost independent of the silver content and the pH of the solution. The influence of the protein solution pH and the protein charge in the BSA solutions permeation was studied. The pH conditions that led to the lower permeate fluxes were observed at the isoelectric point of BSA, pH = 4.8. Full article

Climate-sensitive ice-covered reservoirs are critical components of methane (CH₄) release. To reveal the spatial characteristics of CH₄ concentrations, diffusive fluxes and bubble fluxes during the ice-covered and ice-free periods in northern reservoirs, and in order to clarify the critical influences on their variations. We selected Dongfeng Reservoir, a large reservoir in Northeast China, and conducted six field investigations of CH₄ concentrations and emissions in deep and shallow waters during the ice-covered (January 2022 and January 2023) and ice-free (July 2022, October 2022, March 2023, and September 2023) periods. The results showed that spatially, surface CH₄ concentration and diffusive flux were significantly higher in shallow water than those in deep water. CH₄ bubble flux had the largest range of variation in shallow water, while there was no obvious spatial difference in the proportion of CH₄ in bubbles. Temporally, surface CH₄ concentration, diffusive flux, bubble flux, and the proportion of CH₄ in bubbles were generally high in summer and low in autumn. The surface CH₄ concentration had the largest range of variation in winter, and the CH₄ concentration under the ice was significantly higher in shallow water than those in deep water. Water depth determines the release of CH₄ bubbles from sediments and is the basis for determining deep and shallow water based on bubbles. Ice cover leads to significant differences in CH₄ production and transport compared with ice-free periods by indirectly changing the water environment and directly altering the CH₄ release. CH₄ accumulated under the ice and in the ice will greatly increase the CH₄ release potential during the spring ice-melt period. Overall, this study improves the understanding of CH₄ emissions from reservoirs characterized by ice-covered periods and provides theoretical basis for comprehensive estimation of CH₄ emissions from reservoirs. Full article

An analytical solution is conducted on forced convection in a metal foam partially filled plate channel under asymmetric heat flux conditions, with the aim of optimizing heat transfer performance. The Darcy–Brinkman model and the local thermal non-equilibrium (LTNE) model are employed to predict heat transfer characteristics under varying heat flux ratios (q₁/q₂). Key parameters such as the free zone height, pore density, and thermal conductivity ratio significantly influence heat transfer efficiency. The results indicate that the height of the free region has a greater impact on the flow distribution than porosity and pore density. When the non-dimensional height of the free region is 0.3, the flow fraction in the free region reaches 80%. When the free zone height is H = 0.1, the heat exchanger heat transfer coefficient reaches its maximum value, and the combination of copper (Cu) and R134a refrigerant demonstrates superior convective heat transfer performance compared to the empty channel. Their optimization can lead to substantial improvements in the heat transfer effectiveness of the channel. Full article

The effects of lead (Pb) stress on plant growth and physiological processes may depend on other environmental stresses coinciding. Knowledge of the response of shade-loving plants to stresses, particularly the relationship between Pb stress and light stress, is lacking. The effects of single and combined Pb and light stress on the growth and physiological parameters of Polystichum setiferum and Polystichum setiferum ‘Proliferum’ ferns were evaluated under glasshouse conditions. Treatments comprised control (80% shade, ~111 μmol m⁻² s⁻¹ photosynthetic photon flux density, PPFD), light stress (100% full sunlight, ~525 μmol m⁻² s⁻¹ PPFD), 1000 mg dm⁻³ Pb solution applied to plants under shade and light stress conditions. Under full sunlight, plants had damaged leaves and reduced leaf biomass, and underground parts of the plants had levels of photosynthetic pigments, reducing sugars and total flavonoids. The Pb stress decreased plant growth, reducing sugars, and free amino acids content, and at the same time increased chlorophyll content in P. setiferum and total polyphenols and flavonoid content in P. setiferum ‘Proliferum’. The combined stress of Pb and full sunlight reduced plant growth and the accumulation of pigments, reducing sugars, and free amino acids without affecting the levels of secondary metabolites. P. setiferum plants accumulated more Pb than P. setiferum ‘Proliferum.’ The fern P. setiferum ‘Proliferum’ was more tolerant to abiotic stresses than the fern P. setiferum. This study provided new insights into the response of shade-loving ornamental plants to single and combined Pb and light stress. Full article

Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a refined categorization of non-alcoholic fatty liver disease (NAFLD), highlighting the intricate relationship between hepatic steatosis and metabolic dysfunction. Abdominal obesity (AO), a key diagnostic criterion for metabolic dysfunction, predominantly results from inappropriate diet and unhealthy dietary habits. To comprehensively investigate which dietary factors contribute to MASLD through AO and to understand the underlying biological mechanisms, we initially conducted a systematic review of meta-analysis articles in the PubMed database from the past decade, summarizing dietary factors that affect AO. Subsequently, we conducted targeted searches in the PubMed database for these dietary factors and provided a narrative review of the mechanisms of how these dietary factors lead to AO and how AO exacerbates MASLD. A diet characterized by excessive intake of energy, carbohydrates, fructose, or ultra-processed foods (UPFs) is considered inappropriate. Inappropriate diet leads to the formation of MASLD and AO by enhancing pathways such as de novo lipid synthesis (DNL) in the liver, insulin resistance (IR), gut–liver dysfunction, and inflammation. Dietary interventions for inappropriate diets can effectively intervene in and improve MASLD and AO. The mechanism of inappropriate diet on abdominal fat deposition is through excessive energy or the activation of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) to increase endocortisol secretion. Then, the excessive accumulation of visceral fat facilitates a rapid and augmented flux of free fatty acids (FFAs) to the liver and initiates a series of deleterious effects, including oxidative stress (OS), endoplasmic reticulum stress (ERS), activation of protein kinase C (PKC) pathways, and inflammation. Additionally, FFAs may mediate excessive lipid deposition and hepatocellular damage through the action of hormones. These pathways to liver damage exacerbate MASLD and progression to metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis. Furthermore, investigating other potential mechanisms by which AO may influence MASLD could offer new recommendations for the treatment guidelines of MASLD. Full article

In this study, single crystals of (K_1−xNa_x)NbO₃ are grown by the self-flux crystal growth method and their phase transitions are studied using a combination of Raman scattering and impedance spectroscopy. X-ray diffraction shows that single crystals have a perovskite structure with monoclinic symmetry. Single crystal X-ray diffraction shows that single crystals have monoclinic symmetry at room temperature with space group P12₁1. Electron probe microanalysis shows that single crystals are Na-rich and A-site deficient. Temperature-controlled Raman scattering shows that low temperature monoclinic-monoclinic, monoclinic-tetragonal and tetragonal-cubic phase transitions take place at −20 °C, 220 °C and 440 °C. Dielectric property measurements show that single crystals behave as a normal ferroelectric material. Relative or inverse relative permittivity peaks at ~−10 °C, ~230 °C and ~450 °C with hysteresis correspond to the low temperature monoclinic-monoclinic, monoclinic-tetragonal and tetragonal-cubic phase transitions, respectively, consistent with the Raman scattering results. A conduction mechanism with activation energies of about 0.5–0.7 eV was found in the paraelectric phase. Single crystals show polarization-electric field hysteresis loops of a lossy normal ferroelectric. The combination of Raman scattering and impedance spectroscopy is effective in determining the phase transition temperatures of (K_1−xNa_x)NbO₃. Full article

The icing on wind turbines reduces their aerodynamic performance and can cause other safety issues. Accordingly, in this paper, the de-icing characteristics of a wind turbine blade airfoil under different conditions are investigated using numerical simulation. The findings indicate that when the de-icing time is 10 s, the peak ice thickness on the leading edge of the airfoil surface decreases from 0.28 mm to 0.068 mm and from 0.77 mm to 0.45 mm at low (5 m/s) and high (15 m/s) wind speeds, respectively. This is due to the fact that the ice melting rate is much greater than the icing rate at low wind speeds, while the icing rate increases at high wind speeds. When the de-icing time is 20 s, ice accretion on the leading edge of the airfoil is completely melted. At a low heat flux (8000 W/m²) and high heat flux (12,000 W/m²), the peak ice thickness decreases by 31.2% and 64.9%, respectively. With an increase in de-icing time and heat flux, the peak thickness of runback ice increases. This is due to an increase in runback ice as a result of more ice melting on the leading edge of the airfoil. The surface temperature in the ice-free area is significantly higher than that in the ice-melting area, due to high thermal resistance in the ice-free area. This study will provide guidance for the thermal distribution and coating layout of a wind turbine blade airfoil to make the anti-/de-icing technology more efficient and energy-saving. Full article

We used a replicative lifespan (RLS) experiment of K6001 yeast to screen for anti-aging compounds within lavender extract (Lavandula angustifolia Mill.), leading to the discovery of β-cyclocitral (CYC) as a potential anti-aging compound. Concurrently, the chronological lifespan (CLS) of YOM36 yeast and mammalian cells confirmed the anti-aging effect of CYC. This molecule extended the yeast lifespan and inhibited etoposide (ETO)-induced cell senescence. To understand the mechanism of CYC, we analyzed its effects on telomeres, oxidative stress, and autophagy. CYC administration resulted in notable increases in the telomerase content, telomere length, and the expression of the telomeric shelterin protein components telomeric-repeat binding factor 2 (TRF2) and repressor activator protein 1 (RAP1). More interestingly, CYC reversed H₂O₂-induced telomere damage and exhibited strong antioxidant capacity. Moreover, CYC improved the survival rate of BY4741 yeast under oxidative stress induced by 6.2 mM H₂O₂, increasing the antioxidant enzyme activity while reducing the reactive oxygen species (ROS), reactive nitrogen species (RNS), and malondialdehyde (MDA) levels. Additionally, CYC enhanced autophagic flux and free green fluorescent protein (GFP) expression in the YOM38-GFP-ATG8 yeast strain. However, CYC did not extend the RLS of K6001 yeast mutants, such as Δsod1, Δsod2, Δcat, Δgpx, Δatg2, and Δatg32, which lack antioxidant enzymes or autophagy-related genes. These findings reveal that CYC acts as an anti-aging agent by modifying telomeres, oxidative stress, and autophagy. It is a promising compound with potential anti-aging effects and warrants further study. Full article

KNbO₃ single crystals are grown by the self-flux method using K₂CO₃ as a flux, but often suffer from discolouration. In this work, KNbO₃ single crystals were grown by the flux method using KBO₂ as a flux. KNbO₃ powder was prepared by the solid-state reaction of K₂CO₃ and Nb₂O₅. KBO₂ was fabricated by the reaction of K₂B₄O₇·4H₂O and K₂CO₃. Single crystals of KNbO₃ were grown in a Pt crucible and the structure and dielectric properties of the single crystals were investigated. X-ray diffraction showed the KNbO₃ single crystals to have an orthorhombic Cmm2 perovskite unit cell at room temperature. The existence of ferroelastic domains was revealed by transmission electron microscopy. Electron probe microanalysis showed the single crystals to be stoichiometric and contain small amounts of B. Differential thermal analysis, Raman scattering and impedance spectroscopy were used to study the phase transitions. KBO₂ may be a suitable flux for the growth of KNbO₃ single crystals. Full article

Chickens are a major source of meat and eggs in human food and have significant economic value. Cadmium (Cd) is a common environmental pollutant that can contaminate feed and drinking water, leading to kidney injury in livestock and poultry, primarily by inducing the generation of free radicals. It is necessary to develop potential medicines to prevent and treat Cd-induced nephrotoxicity in poultry. Luteolin (Lut) is a natural flavonoid compound mainly extracted from peanut shells and has a variety of biological functions to defend against oxidative damage. In this study, we aimed to demonstrate whether Lut can alleviate kidney injury under Cd exposure and elucidate the underlying molecular mechanisms. Renal histopathology and cell morphology were observed. The indicators of renal function, oxidative stress, DNA damage and repair, NAD⁺ content, SIRT1 activity, and autophagy were analyzed. In vitro data showed that Cd exposure increased ROS levels and induced oxidative DNA damage and repair, as indicated by increased 8-OHdG content, increased γ-H2AX protein expression, and the over-activation of the DNA repair enzyme PARP-1. Cd exposure decreased NAD⁺ content and SIRT1 activity and increased LC3 II, ATG5, and particularly p62 protein expression. In addition, Cd-induced oxidative DNA damage resulted in PARP-1 over-activation, reduced SIRT1 activity, and autophagic flux blockade, as evidenced by reactive oxygen species scavenger NAC application. The inhibition of PARP-1 activation with the pharmacological inhibitor PJ34 restored NAD⁺ content and SIRT1 activity. The activation of SIRT1 with the pharmacological activator RSV reversed Cd-induced autophagic flux blockade and cell injury. In vivo data demonstrated that Cd treatment caused the microstructural disruption of renal tissues, reduced creatinine, and urea nitrogen clearance, raised MDA content, and decreased the activities or contents of antioxidants (GSH, T-SOD, CAT, and T-AOC). Cd treatment caused oxidative DNA damage and PARP-1 activation, decreased NAD⁺ content, decreased SIRT1 activity, and impaired autophagic flux. Notably, the dietary Lut supplement observably alleviated these alterations in chicken kidney tissues induced by Cd. In conclusion, the dietary Lut supplement alleviated Cd-induced chicken kidney injury through its potent antioxidant properties by relieving the oxidative DNA damage-activated PARP-1-mediated reduction in SIRT1 activity and repairing autophagic flux blockade. Full article

AgNbO₃ (AN) lead-free antiferroelectric material has attracted great attention in recent years. However, little focus has been directed toward a single crystal that can provide more basic information. In this study, we successfully grew high-quality AN single crystals, using a flux method, with dimensions of 5 × 5 × 3 mm³. A systematic investigation into the crystal structure, domain structure, and electrical properties of a [001]-oriented AN single crystal was conducted. X-ray diffraction and domain structure analysis revealed an orthorhombic phase structure at room temperature. Stripe-like 90° domains aligning parallel to the [110] direction with a thickness of approximately 10–20 μm were observed using a polarized light microscope. The temperature dependence of dielectric permittivity showed M1-M2, M2-M3, and M3-O phase transitions along with increasing temperature, but the phase transition temperatures were slightly higher than those of ceramic. The AN single crystal also exhibited double polarization-electric field (P-E) hysteresis loops, which enabled good recoverable energy-storage density and efficiency comparable to ceramic. Additionally, double P-E loops were kept stable at various temperatures and frequencies, demonstrating robust stability and confirming typical antiferroelectric characteristics. Our work provides valuable insights into understanding the fundamental antiferroelectric properties of AN-based materials. Full article