Search Results (529)

Co-infections pose significant challenges not only clinically, but also in terms of simultaneous diagnoses. The development of sensitive, multiplexed analytical platforms is critical for accurately detecting viral co-infections, particularly in complex biological environments. In this study, we present a mass spectrometry (MS)-based detection strategy employing a target-triggered hybridization chain reaction (HCR) to amplify signals and in situ photocleavable mass tags (PMTs) for the simultaneous detection of multiple targets. Hairpin DNAs modified with PMTs and immobilized loop structures on magnetic particles (Loop@MPs) were engineered for each target, and their hybridization and amplification efficiency was validated using native polyacrylamide gel electrophoresis (PAGE) and laser desorption/ionization MS (LDI-MS), with silica@gold core–shell hybrid (SiAu) nanoparticles being employed as an internal standard to ensure quantitative reliability. The system exhibited excellent sensitivity, with a detection limit of 415.12 amol for the hepatitis B virus (HBV) target and a dynamic range spanning from 1 fmol to 100 pmol. Quantitative analysis in fetal bovine serum confirmed high accuracy and precision, even under low-abundance conditions. Moreover, the system successfully and simultaneously detected multiple targets, i.e., HBV, human immunodeficiency virus (HIV), and hepatitis C virus (HCV), mixed in various ratios, demonstrating clear PMT signals for each. These findings establish our approach as a robust and reliable platform for ultrasensitive multiplexed detection, with strong potential for clinical and biomedical research. Full article

To enable the highly sensitive detection of acetylene (C₂H₂) dissolved in transformer oil, a high-power quartz-enhanced photoacoustic spectroscopy (QEPAS) sensing system is proposed. A standard 32.7 kHz quartz tuning fork (QTF) was employed as an acoustic transducer, coupled with an optimized acoustic resonator to enhance the acoustic signal. The laser power was boosted to 150 mW using a C-band erbium-doped fiber amplifier (EDFA), achieving a detection limit of 469 ppb for C₂H₂ with an integration time of 1 s. The headspace degassing method was utilized to extract dissolved gases from the transformer oil, and the equilibrium process for the release of dissolved C₂H₂ was successfully monitored using the developed high-power QEPAS system. This approach provides reliable technical support for the real-time monitoring of the operational safety of power transformers. Full article

A high-power, narrow-linewidth, all-fiber polarization-maintaining (PM) amplifier has been demonstrated. A lasing power of 5870 W has been delivered in master oscillator power amplifier architecture with cascaded white noise source (WNS) phase modulation and bidirectional pumping schemes. The maximal power was limited by the onset of stimulated Brillouin scattering. At the maximum power operation, the amplifier exhibited a 3 dB spectral linewidth of 0.43 nm with beam quality being M² < 1.33 and polarization extinction ratio (PER) being 16.3 dB. To the best of our knowledge, this represents the highest spectral brightness and PER achieved by PM fiber laser systems around 6 kW-level operation. Full article

This study presents an analytical and experimental approach to enhance cantilever-based piezoelectric energy harvesters by optimizing thickness distribution. Using a gradient projection algorithm within a state-space framework, the unimorph beam’s geometry is tailored while constraining the first natural frequency. The objective is to amplify axial strain within the piezoelectric layers, thereby increasing electric polarization and maximizing the conversion efficiency of mechanical vibrations into electrical energy. The steady-state response under harmonic base excitation at resonance was modeled to evaluate the harvester’s dynamic behavior against uniform-thickness counterparts. Results show that the optimized beam achieves significantly higher output voltage and energy harvesting efficiency. Simulations reveal effective strain concentration in regions of high piezoelectric sensitivity, enhancing power generation under resonant conditions. Two independent experimental setups were employed for empirical validation: a non-contact laser vibrometry system (Polytec 3D) and a first resonant base excitation setup. Eigenfrequencies matched within 5% using a Polytec multipath interferometry system, and constant excitation tests showed approximately 30% higher in optimal shapes electrical potential value generation. The outcome of this study highlights the efficacy of geometric tailoring—specifically, non-linear thickness shaping—as a key strategy in achieving enhanced energy output from piezoelectric harvesters operating at their fundamental frequency. This work establishes a practical route for optimizing unimorph structures in real-world applications requiring efficient energy capture from low-frequency ambient vibrations. Full article

The use of analog radio-over-fiber (RoF) systems combined with power-over-fiber (PoF) systems has been proposed in recent years for applications involving remote sensors used in hazardous environments or where electrical wiring may be impractical. This article presents a hybrid architecture topology that combines PoF and RoF, using Raman amplification to obtain RF gain. The first emphasis is placed on the use of two types of high-power laser sources (HPLSs) for the PoF system: a 1480 nm Raman-based HPLS and a 1550 nm HPLS that is based on an erbium-doped fiber amplifier (EDFA). The second emphasis of this paper is on how these two HPLSs simulate Raman scattering (SRS) in the fiber, considering different lengths of SMF 28 for the link. Thus, a comparative analysis is proposed considering the effects induced on the RF signal, mainly focused on its RF power gain ($G_{RF}$), noise figure (NF), and spurious-free dynamic range (SFDR). The obtained results show that the architecture using a PoF system based on the 1550 nm HPLS benefits from a lower noise figure degradation, even when the noise generated by the optical amplification is considered. Full article

The output energy of Laser Active Optical Systems (LAOSs), in which image brightness is amplified within the laser-active medium, is always higher than the input energy. This contrasts with conventional optical systems (OSs). As a result, a LAOS enables the creation of laser beams with tailored energy distribution across the aperture, making them ideal for material processing applications. This concept was first successfully implemented using metal vapor lasers as the gain medium. In these systems, material processing was achieved by using a laser beam that either carried the required energy profile or the image of the object itself. Later, other laser media were utilized for LAOSs, including barium vapor, strontium vapor, excimer XeCl lasers, and solid-state media. Additionally, during the development of these systems, several modifications were introduced. For example, Space-Time Light Modulators (STLMs) and CCD cameras were incorporated, along with the use of multipass amplifiers, disk-shaped or thin-disk (TD) solid-state laser amplifiers, and other advancements. These techniques have significantly expanded the range of power, energy, pulse durations, and operating wavelengths. Currently, TD laser amplifiers and STLMs based on Digital Light Processor (DLP) technology or Digital Micromirror Devices (DMDs) enhance the potential to develop LAOS devices for Subtractive and Additive Technologies (ST, AT), applicable in both macromachining (cutting, welding, drilling) and micro-nano processing. This review presents comparable characteristics and requirements for these various LAOS applications. Full article

In recent years, ultrafast bursts with high power have been applied in many significant fields. However, the peak power of the pulse train generated by fiber lasers is limited by fiber characteristics from nonlinear effects, which can only be at the level of milliwatt. In this research, the pulse frequency is reduced by an AOM pulse picker-integrated modulator. With M2 and pulse width guaranteed, the frequency of the reduced pulse train is amplified by a solid-state three-stage Nd:YVO₄ amplifier system. Finally, the peak power of the pulse train is increased. The final output pulse repetition rate of the experiment is 1 MHz with a pulse width of 8.09 picoseconds and a peak power of up to 3.7 MW. Full article

The development of a high-power 7 × 1 triple-clad fiber combiner aimed at resonantly clad-pump holmium-doped fiber lasers is presented. Thanks to the implementation in the combiner of a low refractive index glass capillary, we show that the developed combiner is compatible with power scaling. Due to the hexagonal arrangement of its seven single-mode input fibers, the presented combiner can also be used in a 6 + 1 × 1 configuration. This characteristic of the fiber component allows for holmium-doped fiber lasers to be studied and developed with both single-oscillator and master-oscillator power amplifier architectures. Full article

Laser-generated structures have a huge potential to induce an alignment of biological cells, which may be important for various fields in medicine and biotechnology. We describe the formation of fs-laser-induced micro- and nanostructures for achieving the directed growth of Schwann cells, a type of glial cell that can support the regeneration of nerve pathways by guiding the neuronal axons in the direction of their alignment. Polymer surfaces, i.e., polycarbonate (PC) or cellulose acetate butyrate (CAB), were exposed to the beam of a 1040 nm Yb-based amplified fs-laser system with a pulse length of about 350 fs. With appropriate parameters, the laser exposure resulted in a surface topography with oriented micro-grooves, which, for PC, were covered with nano-ripples. Schwann cell growth on these substrates was inspected after 3 to 5 days of cultivation by means of scanning electron microscopy (SEM). We show that Schwann cells can grow in a certain direction, predetermined by micro-groove or nano-ripple orientation. In contrast, cells cultivated on randomly oriented nanofibers or unstructured surfaces show an omnidirectional growth behavior. This method may be used in the future to produce nerve conduits for the treatment of injuries to the peripheral nervous system. Full article

Research on the thermal analysis of laser diode (LD) side-pumped amplifiers is a critical step in the design of high-power solid-state laser systems. Instead of adopting a standard solid modeling approach that only considers a laser rod, a fluid–structure interaction model is employed for analysis using the FLUENT 2021 R1 software. This model integrates the cooling structure, coolant, and laser rod, incorporating their relevant material parameters. By considering both uniform and non-uniform inlet velocity distributions as loading conditions, the study reveals remarkably different thermal simulation results. The correlation between thermal analysis outcomes and the total inlet flow rates is calculated, while temperature and stress distributions are obtained under a varying internal heat source. It was observed that the non-uniform inlet velocity distribution has little impact on the rod’s maximum temperature but significantly influences the maximum equivalent stress. This finding underscores the necessity of accounting for non-uniform inlet distributions during the design of laser amplifiers to achieve more accurate thermal simulation results and optimize structural reliability. Full article

High demand for 6G wireless has made photonics-aided D-band (110–170 GHz) communication a research priority. Photonics-aided technology integrates optical and wireless communications to boost spectral efficiency and transmission distance. This study presents a Radio-over-Fiber (RoF) communication system utilizing photonics-aided technology for 4600 m long-distance D-band transmission. We successfully show the transmission of a 50 Gbps (25 Gbaud) QPSK signal utilizing a 128.75 GHz carrier frequency. Notwithstanding these encouraging outcomes, RoF systems encounter considerable obstacles, including pronounced nonlinear distortions and phase noise related to laser linewidth. Numerous factors can induce nonlinear impairments, including high-power amplifiers (PAs) in wireless channels, the operational mechanisms of optoelectronic devices (such as electrical amplifiers, modulators, and photodiodes), and elevated optical power levels during fiber transmission. Phase noise (PN) is generated by laser linewidth. Despite the notable advantages of classical Volterra series and deep neural network (DNN) methods in alleviating nonlinear distortion, they display considerable performance limitations in adjusting for phase noise. To address these problems, we propose a novel post-processing approach utilizing a two-dimensional convolutional neural network (2D-CNN). This methodology allows for the extraction of intricate features from data preprocessed using traditional Digital Signal Processing (DSP) techniques, enabling concurrent compensation for phase noise and nonlinear distortions. The 4600 m long-distance D-band transmission experiment demonstrated that the proposed 2D-CNN post-processing method achieved a Bit Error Rate (BER) of 5.3 × 10⁻³ at 8 dBm optical power, satisfying the soft-decision forward error correction (SD-FEC) criterion of 1.56 × 10⁻² with a 15% overhead. The 2D-CNN outperformed Volterra series and deep neural network approaches in long-haul D-band RoF systems by compensating for phase noise and nonlinear distortions via spatiotemporal feature integration, hierarchical feature extraction, and nonlinear modelling. Full article

This study introduces an innovative analytical solution to the time-fractional Cattaneo heat conduction equation, which models photothermal transport in metallic thin films subjected to short laser pulse irradiation. The model integrates the Caputo fractional derivative of order 0 < p ≤ 1, addressing non-Fourier heat conduction characterized by finite wave speed and memory effects. The equation is nondimensionalized through suitable scaling, incorporating essential elements such as a newly specified laser absorption coefficient and uniform initial and boundary conditions. A hybrid approach utilizing the finite Fourier cosine transform (FFCT) in spatial dimensions and the Laplace transform in temporal dimensions produces a closed-form solution, which is analytically inverted using the two-parameter Mittag–Leffler function. This function inherently emerges from fractional-order systems and generalizes traditional exponential relaxation, providing enhanced understanding of anomalous thermal dynamics. The resultant temperature distribution reflects the spatiotemporal progression of heat from a spatially Gaussian and temporally pulsed laser source. Parametric research indicates that elevating the fractional order and relaxation time amplifies temporal damping and diminishes thermal wave velocity. Dynamic profiles demonstrate the responsiveness of heat transfer to thermal and optical variables. The innovation resides in the meticulous analytical formulation utilizing a realistic laser source, the clear significance of the absorption parameter that enhances the temperature amplitude, the incorporation of the Mittag–Leffler function, and a comprehensive investigation of fractional photothermal effects in metallic nano-systems. This method offers a comprehensive framework for examining intricate thermal dynamics that exceed experimental capabilities, pertinent to ultrafast laser processing and nanoscale heat transfer. Full article

In the N$\nu$DEx collaboration, a high-pressure gas TPC is being developed to search for the neutrinoless double beta decay. The use of electronegative ⁸²SeF₆ gas mandates an ion-TPC. The reconstruction of the z coordinate is to be realized by exploiting the feature of multiple species of charge carriers. As the initial stage of the development, we studied the properties of the ${\mathrm{SF}}_6$ gas, which is non-toxic and has a similar molecular structure to ${\mathrm{SeF}}_6$. In the paper, we present the measurement of drift velocities and mobilities of the majority and minority negative charge carriers found in ${\mathrm{SF}}_6$ at a pressure of 750 Torr, slightly higher than the local atmospheric pressure. The reduced fields range between 3.0 and 5.5 Td. This was performed using a laser beam to ionize the gas inside a small TPC, with a drift length of 3.7 cm. A customized charge-sensitive amplifier was developed to read out the anode signals induced by the slowly drifting ions. The closure test of the reconstruction of the z coordinate using the difference in the velocities of the two carriers was also demonstrated. Full article

In this paper, we present a directly modulated laser (DML) using a partially corrugated grating (PCG) and integrated with a semiconductor optical amplifier (SOA). The influence of the quasi-high-pass filter properties of the SOA on the bandwidth was explored, resulting in high optical power output at lower current levels, with a bandwidth surpassing 25 GHz and an output power above 25 mW. The PCG design boosts the lasing mode’s resistance to random phase fluctuations at the rear facet, hence boosting the mode stability of the laser with a side-mode suppression ratio (SMSR) of over 44 dB. Furthermore, we performed back-to-back (BTB) 26.5625 Gbps NRZ data transmission experiments at room temperature (25 °C) with a modulation current of 60 mA. The results reveal that the transmitter and dispersion eye closure (TDEC) of the fabricated DML is lower than that of a conventional laser when the SOA area current reaches a specific threshold, demonstrating the enhanced signal transmission capabilities of our design. This laser structure offers a fresh strategy for the development of high-power, high-speed DMLs. Full article

Timing measurements are critical for the detectors at the future HL-LHC, to resolve reconstruction ambiguity when the number of simultaneous interactions reaches up to 200 per bunch crossing. The ATLAS collaboration therefore builds a new High-Granularity Timing detector for the forward region. A customized ASIC, called ALTIROC, has been developed, to read out fast signals from low-gain avalanche detectors (LGADs), which has 50 ps time-resolution for signals from minimum-ionizing particles. To meet these requirements, a custom-designed pre-amplifier, a discriminator, and TDC circuits with minimal jitter have been implemented in a series of prototype ASICs. The latest version, ALTIROC3, is designed to contain full functionality. Hybrid assemblies with ALTIROC3 ASICs and LGAD sensors have been characterized with charged-particle beams at CERN-SPS and with laser-light injection. The time-jitter contributions of the sensor, pre-amplifier, discriminator, TDC, and digital readout are evaluated. Full article