Search Results (12)

The gut microbiome, a complex ecosystem of microorganisms, plays a pivotal role in human health and disease. The gut microbiome’s influence extends beyond the digestive system to various organs, and its imbalance is linked to a wide range of diseases, including cancer and neurodevelopmental, inflammatory, metabolic, cardiovascular, autoimmune, and psychiatric diseases. Despite its significance, the interactions between gut bacteria and human proteins remain understudied, with less than 20,000 experimentally validated protein interactions between the host and any bacteria species. This study addresses this knowledge gap by predicting a protein–protein interaction network between gut bacterial and human proteins. Using statistical associations between Pfam domains, a comprehensive dataset of over one million experimentally validated pan-bacterial–human protein interactions, as well as inter- and intra-species protein interactions from various organisms, were used for the development of a machine learning-based prediction method to uncover key regulatory molecules in this dynamic system. This study’s findings contribute to the understanding of the intricate gut microbiome–host relationship and pave the way for future experimental validation and therapeutic strategies targeting the gut microbiome interplay. Full article

Phenological changes in forests directly influence the spatiotemporal dynamics of carbon fixation and the carbon and water cycles in terrestrial ecosystems. Previous studies have shown that variations in biological factors (e.g., canopy height, leaf area, water use efficiency) can increase uncertainty in forest phenology, and these variations are closely linked to tree species and forest age-class structure. However, the interaction mechanisms through which tree species and forest age-class structure influence phenological changes remain insufficiently explored. In this study, phenological changes and their interactions and response mechanisms to different dominant tree species and forest age-class structures were analyzed via Sentinel-2 normalized difference vegetation index (NDVI) time series data from 2020 and 2021 across 480 typical deciduous forest plots in northeastern China. The results were as follows: (1) There were significant differences (p < 0.05) in the intra-annual phenological responses of temperate deciduous landscapes to the interaction between tree species and forest age-class structure. (2) The indirect effect of forest age-class structure through tree species on phenology exceeded the indirect effect of tree species through forest age-class structure, with a difference of 30.77%–35.09%. (3) When the dominant tree species and forest age-class structure were not distinguished, phenological differences in temperate forests ranged from 3 to 41 days and 2 to 23 days, respectively. This study highlights the differential impacts of key biological factors and their interactions on regional forest phenology, offering valuable insights into how these factors influence forest landscapes and providing a theoretical basis for improving forest management strategies. Full article

Scientific research has been acknowledged to play a pivotal role in achieving the United Nations’ 2030 Agenda. Vice-versa, since its adoption, the 2030 Agenda has been reinvigorating the academic production on sustainable development. This study provides a systematic literature review of the most used and newly developed approaches by academic research to support the achievement of the SDGs in the EU. The results are presented by descriptive, bibliometric, and content analysis. The descriptive analysis highlights a rising interest of scholars in operationalizing the 2030 Agenda, with a growing interest at the urban level. A text-mining tool was employed to scan the most investigated SDGs in the selected papers. Major interest by scholars is devoted to environmental concerns (especially linked to SDG 13, 7, 6, 12, and 15), while social issues (e.g., SDG 4, 5, and 10) still deserve more research. The bibliometric analysis unveiled poor intra-cluster connections, highlighting the need for more transdisciplinary research. The most recurrent research fields on the SDGs in the EU are governance, circular economy, ecosystem services, urban localization, and decision making. We advise future studies to focus on gaps highlighted and adopt a system perspective, boosting Policy Coherence across governance levels and scales of implementation by looking at trade-offs and assessing context-specific priorities. Full article

Although understanding the carbon and water cycles of dryland ecosystems in terms of water use efficiency (WUE) is important, WUE and its driving mechanisms are less understood in Central Asia. This study calculated Central Asian WUE for 2001–2021 based on the Google Earth Engine (GEE) platform and analyzed its spatial and temporal variability using temporal information entropy. The importance of atmospheric factors, hydrological factors, and biological factors in driving WUE in Central Asia was also explored using a geographic detector. The results show the following: (1) the average WUE in Central Asia from 2001–2021 is 2.584–3.607 gCkg⁻¹H₂O, with weak inter-annual variability and significant intra-annual variability and spatial distribution changes; (2) atmospheric and hydrological factors are strong drivers, with land surface temperature (LST) being the strongest driver of WUE, explaining 54.8% of variation; (3) the interaction of the driving factors can enhance the driving effect by more than 60% for the interaction between most atmospheric factors and vegetation factors, of which the effect of the interaction of temperature (TEM) with vegetation cover (FVC) is the greatest, explaining 68.1% of the change in WUE. Furthermore, the interaction of driving factors with very low explanatory power (e.g., water pressure (VAP), aerosol optical depth over land (AOD), and groundwater (GWS)) has a significant enhancement effect. Vegetation is an important link in driving WUE, and it is important to understand the mechanisms of WUE change to guide ecological restoration projects. Full article

The ecological water diversion project (EWDP) in the Tarim River Basin, China, aims to allocate more surface water to downstream reaches to restore the degraded ecosystems. However, seasonal changes in ecological water diversion; the factors (natural and anthropogenic) controlling the ecological water diversion, whether the seasonal delivery of water temporally corresponded to the vegetation’s seasonal water demands; and the benefits of the ecological water diversion through overflowing surface water irrigation are unclear. To address the above issues, this study examines the intra-annual changes and its influencing factors in ecological water diversion (inundation) in the Daliyaboyi Oasis in the lower Keriya River valley within the Tarim Basin, discusses whether the seasonal delivery of water temporally corresponded to the vegetation’s seasonal water demands, and assesses the ecological benefits of overflowing surface water irrigation. Inundation was quantified by digitizing monthly changes in the inundated area from 2000 to 2018 in the oasis using 184 Landsat images. The results demonstrate that seasonal changes in the inundated area varied significantly, with maximum peaks occurring in February and August; a period of minimal inundation occurred in May. Differences in the July/August peak (i.e., July or August) in inundation dominated the inter-annual variations in the inundated area over the 19-year study period. The two peaks in the inundation area were temporally consistent with the vegetation’s seasonal water demand. Local residents have used ecological water to irrigate vegetation in different parts of the oasis during different seasons, an approach that expanded the inundated area. The February peak in the inundated area is closely linked to elevated downstream groundwater levels and the melting of ice along the river. The August peak is related to a peak in runoff from headwater areas. The minimum May value is correlated to a relatively low value in upstream runoff and an increase in agricultural water demand. Thus, natural factors control the intra-annual and inter-annual variations in the inundated area. Humans changed the spatial distribution of the inundated area and enhanced the water’s ecological benefits, but did not alter the correlation between peak periods of inundation and vegetation water demand. The results from this study improve our understanding of the benefits of the EWDP in the Tarim River Basin. Full article

Partitioning of evapotranspiration (ET) into transpiration (T) and residual evaporation (E) is a challenging but important task in order to assess the dynamics of increasingly scarce water resources in forest ecosystems. The T/ET ratio has been linked to the ecosystem water use efficiency of temperate forests, and thus is an important index for understanding utilization of water resources under global climate change. We used concurrent sap flow and eddy-covariance measurements to quantify the ET partitioning in pure European beech forest during the 2019–2020 period. The sap flow data were upscaled to stand level T and combined with stand level ET to calculate the T/ET ratio. We analysed intra-annual dynamics, the effect of seasonality and the impact of meteorological conditions on T, ET and T/ET. Annual T/ET of a pure European beech ecosystem was 0.48, falling at the lower end of reported global T/ET values for forest ecosystems. T/ET showed significant seasonal differences throughout spring (T/ET = 0.28), summer (T/ET = 0.62) and autumn (T/ET = 0.35). Air temperature (R² = 0.45–0.63), VPD (R² = 0.47–0.6) and PAR (R² = 0.32–0.63) affected the daily dynamics of T, ET and T/ET; however, soil water content (SWC) had no significant effect. Mature European beech trees showed more anisohydric behaviour and relatively stable T/ET, even under decreasing SWC. The results improve the understanding of ecosystem scale T, ET and T/ET intra-annual dynamics and environmental constraints in anisohydric mature European beech. Full article

Grape cultivation in Sonora, Mexico is one of the most notable in the world, but it is restricted to certain areas and uses a conventional production approach. The objective of this work is to evidence the development of the establishment of an organic vineyard as a novel cultivation pattern in an agrosystem of the intermontane valley of the Sonoran Desert, Mexico, from its endogenous variables and its link with the surrounding environment, to an integrated approach between the organic and the sustainable. The approach is conducted by conceptualizing the vineyard as a Strategic Multifactorial Node (SMN) with ecological influence towards its immediate environment, evaluated from endogenous variables of the vineyard itself and those linked to the agrosystem of direct influence. To measure the degree of influence between the vineyard and the surrounding ecosystems, sustainability values between 0 and 1 were assigned, derived from the activities and conditions included in SDGs 13 and 15. Among the vineyard’s results, a percentage of weed cover equal to 96% stands out, as well as the presence of entomofauna and avifauna in a ratio of 78:22. In the component exogenous to the vineyard, that is, the degree of sustainable influence for the elements of the adjacent desert agrosystem, resulted in 0.98 for Soil Conservation Areas; 0.79 for edaphic organic matter, 0.97 for maintenance of water, and 0.96 for soil microorganisms. SMN promoted lateral conservation of the water-soil binomial, limited erosion, decreased soil loss, and increased soil fertilization. Full article

Animal behavior is greatly shaped by the ‘landscape of fear’, induced by predation risk, and the equivalent ‘landscape of disgust’, induced by parasitism or infection risk. However, the role that carrion may play in these landscapes of peril has been largely overlooked. Here, we aim to emphasize that animal carcasses likely represent ubiquitous hotspots for both predation and infection risk, thus being an outstanding paradigm of how predation and parasitism pressures can concur in space and time. By conducting a literature review, we highlight the manifold inter- and intra-specific interactions linked to carrion via predation and parasitism risks, which may affect not only scavengers, but also non-scavengers. However, we identified major knowledge gaps, as reviewed articles were highly biased towards fear, terrestrial environments, vertebrates, and behavioral responses. Based on the reviewed literature, we provide a conceptual framework on the main fear- and disgust-based interaction pathways associated with carrion resources. This framework may be used to formulate predictions about how the landscape of fear and disgust around carcasses might influence animals’ individual behavior and ecological processes, from population to ecosystem functioning. We encourage ecologists, evolutionary biologists, epidemiologists, forensic scientists, and conservation biologists to explore the promising research avenues associated with the scary and disgusting facets of carrion. Acknowledging the multiple trophic and non-trophic interactions among dead and live animals, including both herbivores and carnivores, will notably improve our understanding of the overlapping pressures that shape the landscape of fear and disgust. Full article

Worldwide, forests provide natural resources and ecosystem services. However, forest ecosystems are threatened by increasing forest disturbance dynamics, caused by direct human activities or by altering environmental conditions. It is decisive to reconstruct and trace the intra- to transannual dynamics of forest ecosystems. National to local forest authorities and other stakeholders request detailed area-wide maps that delineate forest disturbance dynamics at various spatial scales. We developed a time series analysis (TSA) framework that comprises data download, data management, image preprocessing and an advanced but flexible TSA. We use dense Sentinel-2 time series and a dynamic Savitzky–Golay-filtering approach to model robust but sensitive phenology courses. Deviations from the phenology models are used to derive detailed spatiotemporal information on forest disturbances. In a first case study, we apply the TSA to map forest disturbances directly or indirectly linked to recurring bark beetle infestation in Northern Austria. In addition to spatially detailed maps, zonal statistics on different spatial scales provide aggregated information on the extent of forest disturbances between 2018 and 2019. The outcomes are (a) area-wide consistent data of individual phenology models and deduced phenology metrics for Austrian forests and (b) operational forest disturbance maps, useful to investigate and monitor forest disturbances to facilitate sustainable forest management. Full article

Dry forests in Sub-Saharan Africa are of critical importance for the livelihood of the local population given their strong dependence on forest products. Yet these forests are threatened due to rapid population growth and predicted changes in rainfall patterns. As such, large-scale woody cover monitoring of tropical dry forests is urgently required. Although promising, remote sensing-based estimation of woody cover in tropical dry forest ecosystems is challenging due to the heterogeneous woody and herbaceous vegetation structure and the large intra-annual variability in the vegetation due to the seasonal rainfall. To test the capability of Sentinel-2 satellite imagery for producing accurate woody cover estimations, two contrasting study sites in Ethiopia and Tanzania were used. The estimation accuracy of a linear regression model using the Normalised Difference Vegetation Index (NDVI), a Partial Least Squares Regression (PLSR), and a Random Forest regression model using both single-date and multi-temporal Sentinel-2 images were compared. Additionally, the robustness and site transferability of these methods were tested. Overall, the multi-temporal PLSR model achieved the most accurate and transferable estimations (R² = 0.70, RMSE = 4.12%). This model was then used to monitor the potential increase in woody coverage within several reforestation projects in the Degua Tembien district. In six of these projects, a significant increase in woody cover could be measured since the start of the project, which could be linked to their initial vegetation, location and shape. It can be concluded that a PLSR model combined with Sentinel-2 satellite imagery is capable of monitoring woody cover in these tropical dry forest regions, which can be used in support of reforestation efforts. Full article

Osteosarcomas are the most frequent primary bone sarcomas, affecting mainly children, adolescents, and young adults, and with a second peak of incidence in elderly individuals. The current therapeutic management, a combined regimen of poly-chemotherapy and surgery, still remains largely insufficient, as patient survival has not improved in recent decades. Osteosarcomas are very heterogeneous tumors, both at the intra- and inter-tumor level, with no identified driver mutation. Consequently, efforts to improve treatments using targeted therapies have faced this lack of specific osteosarcoma targets. Nevertheless, these tumors are inextricably linked to their local microenvironment, composed of bone, stromal, vascular and immune cells and the osteosarcoma microenvironment is now considered to be essential and supportive for growth and dissemination. This review describes the different actors of the osteosarcoma microenvironment and gives an overview of the past, current, and future strategies of therapy targeting this complex ecosystem, with a focus on the role of extracellular vesicles and on the emergence of multi-kinase inhibitors. Full article

Higher biodiversity leads to more productive ecosystems which, in turn, supports more biodiversity. Ongoing global changes affect ecosystem productivity and, therefore, are expected to affect productivity-biodiversity relationships. However, the magnitude of these relationships may be affected by baseline biodiversity and its lifeforms. Cork oak (Quercus suber) woodlands are a highly biodiverse Mediterranean ecosystem managed for cork extraction; as a result of this management cork oak woodlands may have both tree and shrub canopies, just tree and just shrub canopies, and just grasslands. Trees, shrubs, and grasses may respond differently to climatic variables and their combination may, therefore, affect measurements of productivity and the resulting productivity-biodiversity relationships. Here, we asked whether the relationship between productivity and climate is affected by the responses of trees, shrubs, and grasses in cork oak woodlands in Southern Portugal. To answer this question, we linked a 15-year time series of Enhanced Vegetation Index (EVI) derived from Landsat satellites to micrometeorological data to assess the relationship between trends in EVI and climate. Between 2000 and 2013 we observed an overall decrease in EVI. However, EVI increased over cork oaks and decreased over shrublands. EVI trends were strongly positively related to changes in relative humidity and negatively related to temperature. The intra-annual EVI cycle of grasslands and sparse cork oak woodland without understorey (savannah-like ecosystem) had higher variation than the other land-cover types. These results suggest that oaks and shrubs have different responses to changes in water availability, which can be either related to oak physiology, to oaks being either more resilient or having lagged responses to changes in climate, or to the fact that shrublands start senesce earlier than oaks. Our results also suggest that in the future EVI could improve because the rate of increase in minimum EVI is greater than the rate of decrease in maximum EVI, and that this is contingent on management of the shrub understorey as it affects the rate of decrease in maximum EVI. This will be the challenge for the persistence of cork oak woodlands, their associated biodiversity and social-ecological system. Full article