Search Results (3,525)

The Apple TV+ series Severance (2022–present) offers a dystopian portrayal of workplace life that intensifies real-world dynamics of control, boundary management, and identity regulation. This paper analyzes Severance as a speculative case study in organizational theory, treating the show’s fictional world as a site for conceptual reflection. Drawing on critical management studies and labor process theory, we examine how mechanisms of control, the regulation of work–life boundaries, and the fragmentation of autonomy and subjectivity are depicted in extreme form. We argue that fiction—particularly speculative satire—can serve as a tool of theoretical production, not merely illustration. Rather than restating familiar critiques, Severance allows us to see workplace norms with renewed clarity, surfacing the moral and psychological consequences of surveillance, coercion, and instrumentalized consent. A methodological note outlines our interpretive approach to narrative fiction, and a discussion of implications situates the analysis within broader debates about organizational ethics, resilience, and critique. Full article

Background/Objectives: Breast cancer was the leading cause of malignant tumors among women in 2022. About two-thirds of breast cancer cases are hormone-receptor-positive. In these patients, aromatase inhibitors are a mainstay of treatment, but associated musculoskeletal symptoms can negatively affect patient compliance. Aromatase-inhibitor-induced carpal tunnel syndrome represents one of the main causes of aromatase inhibitor discontinuation, with a non-compliance rate of up to 67%, potentially leading to increased cancer mortality. This study investigates estrogen receptor expression in aromatase-inhibitor-induced carpal tunnel syndrome tissues, in order to better define its etiopathogenesis and derive preventive or therapeutic measures that can improve aromatase inhibitor patient compliance. To our knowledge, there is no study on this subject in the literature. Methods: Between 2023 and 2024, we recruited 14 patients at the Jewish Hospital of Rome, including seven patients with aromatase-inhibitor-induced carpal tunnel syndrome (study group) and seven with postmenopausal idiopathic carpal tunnel syndrome (control group). Each patient was evaluated based on a clinical visit, a questionnaire, instrumental exams, and serum hormone dosages and were treated with open carpal tunnel release surgery, during which transverse carpal ligament and flexor tenosynovium samples were collected. For immunohistochemical experiments, sections were treated with anti-estrogen receptor α and anti-estrogen receptor β antibodies. Results: The immunohistochemical features in the study and control groups were similar, demonstrating that tissues affected by aromatase-inhibitor-induced carpal tunnel syndrome are targets of direct estrogen action and that estrogen deprivation is correlated with disease etiogenesis. Surgery was effective in patient treatment. Conclusions: Aromatase-inhibitor-induced carpal tunnel syndrome represents a newly defined form of the disease. This syndrome represents one of the main causes of aromatase inhibitor discontinuation, due to its negative impact on the patient’s quality of life. The identification by clinicians of aromatase inhibitor use as a possible risk factor for carpal tunnel syndrome development is of essential importance, as early diagnosis and prompt management can improve patient compliance and overall breast cancer treatment outcomes. Full article

Rapid pavement repair demands materials that combine accelerated strength gains, dimensional stability, long-term durability, and sustainability. However, finding materials or formulations that offer these balances remains a critical challenge. This study systematically evaluates two polymer-modified belitic calcium sulfoaluminate (CSA) concretes—CSAP (powdered polymer) and CSA-LLP (liquid polymer admixture)—against a traditional Type III Portland cement (OPC) control under both laboratory and realistic outdoor conditions. Laboratory specimens were tested for fresh properties, early-age and later-age compressive, flexural, and splitting tensile strengths, as well as drying shrinkage according to ASTM standards. Outdoor 5 × 4 × 12-inch slabs mimicking typical jointed plain concrete panels (JPCPs), instrumented with vibrating wire strain gauges and thermocouples, recorded the strain and temperature at 5 min intervals over 16 weeks, with 24 h wet-burlap curing to replicate field practices. Laboratory findings show that CSA mixes exceeded 3200 psi of compressive strength at 4 h, but cold outdoor casting (~48 °F) delayed the early-age strength development. The CSA-LLP exhibited the lowest drying shrinkage (0.036% at 16 weeks), and outdoor CSA slabs captured the initial ettringite-driven expansion, resulting in a net expansion (+200 µε) rather than contraction. Approximately 80% of the total strain evolved within the first 48 h, driven by autogenous and plastic effects. CSA mixes generated lower peak internal temperatures and reduced thermal strain amplitudes compared to the OPC, improving dimensional stability and mitigating restraint-induced cracking. These results underscore the necessity of field validation for shrinkage compensation mechanisms and highlight the critical roles of the polymer type and curing protocol in optimizing CSA-based repairs for durable, low-carbon pavement rehabilitation. Full article

The coastal sandy land in northeast Hainan Province is typical for this land type, also exhibiting strong sand activity. This study is based on wind speed, wind direction, and sediment transport data obtained at a field meteorological station using an omnidirectional sand accumulation instrument from 2020 to 2024, studying the coastal aeolian environment and sediment transport distribution characteristics in the region. Its findings provide a theoretical basis for comprehensively analyzing the evolution of coastal aeolian landforms and the evaluation and control of coastal aeolian hazards. The research results show the following: (1) The annual average threshold wind velocity for sand movement in the study area is 6.84 m/s, and the wind speed frequency (frequency of occurrence) is 51.54%, dominated by easterly (NE, ENE) and southerly (S, SSE) winds. (2) The drift potential (DP) refers to the potential amount of sediment transported within a certain time and spatial range, and the annual drift potential (DP) and resultant drift potential (RDP) of Mulan Bay from 2020 to 2024 were 550.82 VU and 326.88 VU, respectively, indicating a high-energy wind environment. The yearly directional wind variability index (RDP/DP) was 0.59, classified as a medium ratio and indicating blunt bimodal wind conditions. The yearly resultant drift direction (RDD) was 249.45°, corresponding to a WSW direction, indicating that the sand in Mulan Bay is generally transported in the southwest direction. (3) When the measured data extracted from the sand accumulation instrument in the study area from 2020 to 2024 were used for statistical analysis, the results showed that the total sediment transport rate (the annual sediment transport of the observation section) in the study area was 110.87 kg/m·a, with the maximum sediment transport rate in the NE direction being 29.26 kg/m·a. These results suggest that when sand fixation systems are constructed for relevant infrastructure in the region, the construction direction of protective forests and other engineering measures should be perpendicular to the net direction of sand transport. Full article

Background: School-based tobacco control policies are critical for preventing youth tobacco use. While many districts adopt formal policies to create smoke- and vape-free environments, the degree to which these policies are enforced at the school level may vary, influencing their effectiveness. Little is known about how consistently such policies are implemented across schools within urban school districts. Objectives: This study aimed to examine the existence and enforcement of school-level tobacco control policies in an urban public school system, using Baltimore City schools as a case example. Methods: We conducted a survey of school personnel from 20 high schools in Baltimore City in 2024. The survey instrument assessed the presence and enforcement of policies related to tobacco use prevention, communication, signage, disciplinary actions, and institutional support. Descriptive statistics (frequencies and percentages) were used to summarize responses. Spearman correlations were also used for bivariate correlations. Additional school-level and neighborhood-level contextual data were collected from the internet (neighborhood socioeconomic status and school performance). Results: While many policies existed across the 20 participating schools, their enforcement was widely inconsistent. Most schools reported the existence of policies prohibiting tobacco use in school buildings (60%) and vehicles (55%). However, few schools had visible tobacco-free signage (35%) or offered cessation programs (15%). Communication of policies to students (70%) and staff (65%) was the most commonly enforced aspect of tobacco control policies. Conclusions: Findings suggest that while tobacco control policies may be adopted across urban school systems, their enforcement at the school level remains uneven. Greater attention may be needed to support policy implementation and to reduce variability in school-level practices. Baltimore City serves as a useful case study to understand these challenges and identify opportunities for strengthening school-based tobacco prevention efforts. Full article

A concept towards current measurement in low and medium voltage power distribution networks is presented. The concentric magnetic field around the current-carrying conductor should be measured using a nitrogen-vacancy quantum magnetic field sensor. A bottleneck in current measurement systems is the readout electronics, which are usually based on optically detected magnetic resonance (ODMR). The idea is to have a hardware that tracks up to four resonances simultaneously for the detection of the three-axis magnetic field components and the temperature. Normally, expensive scientific instruments are used for the measurement setup. In this work, we present an electronic device that is based on a Zynq 7010 FPGA (Red Pitaya) with an add-on board, which has been developed to control the excitation laser, the generation of the microwaves, and interfacing the photodiode, and which provides additional fast digital outputs. The T1 measurement was chosen to demonstrate the ability to read out the spin of the system. Full article

The evidence for photobiomodulation in reducing postoperative pain after endodontic instrumentation is classified as low or very low certainty, indicating a need for further research. Longitudinal pain assessments over 24 h are crucial, and studies should explore these pain periods. Background/Objectives: This double-blind, randomized controlled clinical trial evaluated the effect of PBM on pain following single-visit endodontic treatment of maxillary molars at 4, 8, 12, and 24 h. Primary outcomes included pain at 24 h; secondary outcomes included pain at 4, 8, and 12 h, pain during palpation/percussion, OHIP-14 analysis, and frequencies of pain. Methods: Approved by the Research Ethics Committee (5.598.290) and registered in Clinical Trials (NCT06253767), the study recruited adults (21–70 years) requiring endodontic treatment in maxillary molars. Fifty-eight molars were randomly assigned to two groups: the PBM Group (n = 29), receiving conventional endodontic treatment with PBM (100 mW, 333 mW/cm², 9 J distributed at 3 points near root apices), and the control group (n = 29), receiving conventional treatment with PBM simulation. Pain was assessed using the Visual Analog Scale. Results: Statistical analyses used chi-square and Mann–Whitney tests, with explained variance (η²). Ten participants were excluded, leaving 48 patients for analysis. No significant differences were observed in postoperative pain at 24, 4, 8, or 12 h, or in palpation/percussion or OHIP-14 scores. Pain frequencies ranged from 12.5% to 25%. Conclusions: PBM does not influence post-treatment pain in maxillary molars under these conditions. These results emphasize the importance of relying on well-designed clinical trials to guide treatment decisions, and future research should focus on personalized dosimetry adapted to the anatomical characteristics of the treated dental region to enhance the accuracy and efficacy of therapeutic protocols. Full article

Background: The efficient control of hygiene and Campylobacter’s contamination status at various steps of poultry meat production is essential for the prevention of Campylobacter transmission to humans. Microbiological methods are laborious and time-consuming, and molecular methods of detection are often too skill- and infrastructure-demanding. Methods: We have developed CampyTube, a simple and user-friendly format for the integration of isothermal DNA amplification with embedded instrument-free detection on a miniaturized lateral flow test in a single vial. All test components, from the dry amplification reagents to the mini lateral flow tests, are incorporated into a standard single vial, which is closed after the addition of the liquid sample and never has to be opened again. This ensures the absolute prevention of carry-over contamination and makes the system very safe and simple to use in point-of-need settings. Results: As few as 60 Campylobacter genome copies per reaction could be successfully detected with CampyTube. We have primarily developed and evaluated CampyTube for the detection of Campylobacter in chicken neck skin samples and could reach 100% sensitivity and 100% specificity in the samples exceeding the regulatory limit of 1000 CFU/g confirmed microbiologically, while the sensitivity in all samples that tested positive using qPCR (1.4 × 10²–2.5 × 10⁶ genome copies/g) was 71.1%. We discuss the impact of sample preparation on CampyTube performance and suggest further options for test optimization. Conclusions: CampyTube is a highly versatile and efficient, yet simple, affordable, and material-saving system that can be adapted for other targets and sample types. Full article

This article examines how digital innovation ecosystems have emerged as strategic institutions of power in contemporary world politics. It argues that, unlike Cold War technological rivalries driven by centralized, state-led control, today’s digital competition depends on states’ capacity to orchestrate scalable, multistakeholder ecosystems. Using a cultural–institutional framework, we explain how differences in strategic culture and institutional governance impact the ecosystem’s vitality and performance. A qualitative comparative analysis of the United States, China, and Russia reveals that constructive orchestration, aligning state institutions with generative, commercial-to-national innovation flows, enhances digital leadership, whereas rigid, obstructive governance limits it. This highlights ecosystem governance as a critical dimension of statecraft in the digital age. The findings underscore that the positions of great powers in the global technological hierarchy depend not only on resources or capabilities but also on the effectiveness of ecosystem governance as an evolving instrument of geopolitical power. Full article

This study aimed to examine how downward load applied during instrumentation affects the stress generation and shaping properties in thermally treated and non-treated NiTi rotary instruments. ProTaper Universal (PTU; non-thermally treated) and ProTaper Gold (PTG; thermally treated) were used to prepare J-shaped canals in resin blocks. Load-controlled automated instrumentation and torque/force sensing devices were employed with preset downward loads of 1, 2, or 3 N (n = 10 each). The torque/force, instrumentation time, and canal-centering ratio were measured and analyzed using two-way or one-way analysis of variance with Tukey’s test (α = 0.05). In the PTU-1N group, instrumentation was not completed because a ledge was formed in all canals. The PTU-3N group showed significantly greater upward force (screw-in force) and clockwise torque, along with a significantly smaller canal-centering ratio (less deviation) at the apical 0 mm level, than the PTU-2N group (p < 0.05). The downward load did not influence the instrumentation time (p > 0.05). In the PTG groups, these effects of downward load on the force generation and canal-centering ratio were not significant (p > 0.05). In the non-thermally treated PTU instruments, greater downward loads enhanced screw-in force while decreasing apical canal deviation; however, these effects were abolished in the thermally treated PTG instruments. This study highlights the importance of adapting the instrumentation technique with instrument characteristics: thermally treated flexible instruments facilitate smoother use, while stiffer, non-thermally treated ones may require precise control of downward loads. Full article

Endoscopic dacryocystorhinostomy (DCR) is a widely recognized and highly effective procedure. This surgical procedure is performed globally, with minimal modifications across different regions. Background/Objectives: The fundamental goal of DCR is to marsupialize the lacrimal sac into the nasal cavity, which helps eliminate epiphora (excessive tearing) and recurrent dacryocystitis (inflammation of the tear sac). With advancements in technology, new instruments are being developed to minimize risks and maximize efficacy, ultimately improving surgeon convenience, patient safety, and quality of life. One such innovation is piezosurgery, a method of bone cutting that utilizes ultrasound vibrations. Originally prevalent in oral and maxillofacial surgery, piezosurgery is now being applied in many clinical applications. Its primary advantages include the preservation of soft tissues, precise bone cutting, and the ability to work effectively in narrow spaces. Methods: This article outlines the standard technique used at our facility for performing endoscopic dacryocystorhinostomy (DCR) with a piezoelectric system. We describe the preoperative evaluation, intraoperative techniques, and postoperative care to present what we consider the standard procedure in our clinic. Results and Conclusions: Piezosurgery’s selective cutting prevents damage to surrounding soft tissues, making it theoretically advantageous in DCR by preserving tissue integrity. Additional case–control and multicenter studies are necessary to compare its outcomes with those of traditional osteotomy, particularly in relation to the potential increase in operative time. Full article

Background/Objectives: Elevated serum uric acid levels are associated with the occurrence, development, and adverse events of coronary heart disease (CHD) and CHD risk factors. However, the extent of any pathogenic effect of the serum uric acid on CHD and whether CHD risk factors play a confounding or mediating role are still unclear. Methods: The potential causal associations of serum uric acid with CHD were evaluated via cross-trait linkage disequilibrium score regression analysis and Mendelian randomization. The pleiotropy of genetic tools was analyzed via a Bayesian colocalization approach. Moreover, we utilized two-step MR to identify risk factors mediating the relationship between uric acid and CHD. Results: Mendelian randomization results derived from two genetic instrument selection strategies support that serum uric acid levels have a significant causal relationship with coronary artery disease, stable angina pectoris, and myocardial infarction. This causal relationship was partially mediated by diastolic blood pressure, mean arterial pressure, and serum triglycerides. Transcriptomic analysis revealed that serum uric acid may directly contribute to the development of atherosclerosis by inducing transcriptomic changes in macrophages. Conclusions: Our findings highlight that the control of serum urate concentration in the long-term management of CHD patients may be necessary. Well-designed clinical trials and foundational research are presently required to furnish conclusive proof regarding the specific clinical scenarios in which adequate reduction in urate concentrations can confer cardiovascular advantages. Full article

Food addiction is characterized by compulsive consumption and impaired control over highly palatable foods, with neurobiological mechanisms analogous to substance use disorders. The Yale Food Addiction Scale 2.0 (YFAS 2.0) is the most widely used instrument to assess these symptoms; however, its psychometric properties have not been validated in Mexican adults. This study aimed to perform the cross-cultural adaptation of the YFAS 2.0 and validate its psychometric properties for the identification of food addiction in the Mexican adult population. A cross-sectional study was conducted in 500 Mexican adults aged 20 years or older. Participants completed the cross-culturally adapted YFAS 2.0. Exploratory and hierarchical factor analyses were conducted. Reliability was assessed using Cronbach’s alpha and omega coefficients, and model fit was evaluated through global fit indices. The scale showed high internal consistency (α = 0.88; ωt = 0.87; ωh = 0.89). The Kaiser–Meyer–Olkin index was 0.815 and Bartlett’s test was significant (χ² = 4367.88; df = 595; p < 0.001). Exploratory factor analysis supported a unidimensional structure, with the first factor explaining 21.3% of the total variance. In the hierarchical model, all items loaded substantially onto the general factor. Fit indices indicated excellent model fit (CFI = 0.99; TLI = 0.98; RMSEA = 0.001; RMR = 0.004). The YFAS 2.0 is a valid and reliable instrument for identifying food addiction symptoms in Mexican adults. It may be useful in clinical practice and research on eating disorders. Full article

Elucidating the trade-offs and synergies among ecosystem services is crucial for effective ecosystem management and the promotion of sustainable development in specific regions. The Hexi Corridor, a vital agricultural hub in Northwest China, is instrumental in both ecological conservation and socioeconomic advancement throughout the area. Utilizing an integrated “water–soil–carbon–grain” framework, this study conducted a quantitative assessment of four essential ecosystem services within the Hexi Corridor from 2000 to 2020: water yield, soil conservation, vegetation carbon sequestration, and grain production. Our research thoroughly explores the equilibrium and synergistic interactions between grain production and other ecosystem services, while also exploring potential strategies to boost grain yields through the precise management of these services. The insights garnered are invaluable for strategic regional development and will contribute to the revitalization efforts in Northwest China. Key findings include the following: (1) between 2000 and 2020, grain production exhibited a steady increase, alongside rising trends in water yields, soil conservation, and carbon sequestration, all of which demonstrated significant synergies with agricultural productivity; (2) in areas identified as grain production hotspots, there were stronger positive correlations between grain output and carbon sequestration services, soil conservation, and water yields than the regional averages, suggesting more pronounced mutual benefits; (3) the implementation of strategic initiatives such as controlling soil erosion, expanding afforestation efforts, and enhancing water-saving irrigation infrastructure could simultaneously boost ecological services and agricultural productivity. These results significantly enhance our comprehension of the interplay between ecosystem services in the Hexi Corridor and present practical approaches for the optimization of regional agricultural systems. Full article

In response to the demand for precise measurement of illuminance distribution in the quality control of LED monitoring fill light products and the iterative direction of secondary optical design, distributed photometric sensors have shown advantages, but their measurement uncertainty assessment faces challenges. This paper addresses the problem of uncertainty evaluation in photometric parameter measurement with a two-dimensional horizontal distributed photometric sensor and proposes an uncertainty evaluation framework for this task. We have established an uncertainty analysis model for the measurement system and provided two uncertainty synthesis methods, The Guide to the Expression of Uncertainty in Measurement and the Monte Carlo method. This study designed illuminance measurement experiments to validate the feasibility of the proposed uncertainty evaluation method. The results demonstrate that the actual probability distribution of the measurement data follows a trapezoidal distribution. Furthermore, the expanded uncertainty calculated using the GUM method was 21.1% higher than that obtained by the MCM. This work effectively addresses the uncertainty evaluation challenge for illuminance measurement tasks using a two-dimensional horizontal distributed photometric sensor. The findings offer valuable reference for the uncertainty assessment of other high-precision optical instruments and possess significant engineering value in enhancing the reliability of optical metrology systems. Full article