Search Results (1,815)

In the macro context of promoting sustainable development and achieving net zero emissions, the role of green technology innovation, renewable energy utilization and environmental policy is crucial. However, there is still a lack of consistent empirical evidence regarding the combined emission reduction effect of these three factors in OECD countries. This study aims to empirically examine the combined impact of green technology innovation (GTI), renewable energy consumption (REC), and environmental taxes (ETAX) on carbon dioxide emissions. We expect that the former two will effectively reduce emissions, while the effect of environmental taxes depends on their design. Based on the panel data of 35 OECD economies from 1990 to 2019, this study adopts the augmented mean group (AMG) as the main estimation method, and uses the common correlation mean group (CCEMG) for the robustness test. To control potential endogenous issues, the difference generalized method of moments (GMM) is also employed for estimation. The causal relationship between variables is tested using the Dumitrescu–Herlin method. The results show that, as expected, GTI and REC have a significant negative impact on carbon dioxide reduction. However, ETAX is positively correlated with carbon emissions and does not have statistical significance, which deviates from the ideal policy effect and suggests that there may be efficiency bottlenecks in the current tax design. The causality test further reveals that there is a significant two-way causal relationship between CO₂ emissions and GTI, REC, ETAX, GDP, and fossil fuel consumption (FEC). Therefore, it is recommended that OECD countries give priority to expanding investment in green technologies and renewable energy infrastructure and re-evaluate and optimize environmental tax policies to effectively promote the transition to a low-carbon economy. Full article

Background: Advances in breast reconstruction have transformed the recovery pathway for women undergoing mastectomy. What was once viewed mainly as a cosmetic option is now recognized as part of modern oncologic care, restoring not only body image but also confidence and quality of life. Yet, surgeons still face the same central dilemma: choosing between implant-based (IBR) and autologous reconstruction (ABR), particularly when postmastectomy radiotherapy (PMRT) is planned. Methods: We reviewed major studies published between 2014 and 2024, combining evidence from observational cohorts and recent meta-analyses that together report on more than 60,000 reconstructed breasts. Outcomes of interest included surgical complications, reconstructive failure, BREAST-Q patient-reported domains, and the impact of PMRT on both techniques. Data were interpreted in light of contemporary reconstructive innovations such as prepectoral implants, acellular dermal matrices, and robotic or sensory-nerve–enhanced autologous procedures. Results: Autologous reconstruction generally provided higher satisfaction and better psychosocial and sexual well-being, particularly in patients who received PMRT. Implant-based reconstruction offered faster recovery and shorter hospitalization but was more vulnerable to capsular contracture and reconstructive loss after irradiation. Across all eligible cohorts, reconstruction—immediate or delayed—did not increase local recurrence or compromise overall survival when adjuvant therapy was delivered without delay. Conclusions: Both IBR and ABR are oncologically safe and contribute meaningfully to recovery after mastectomy. Future progress will depend on combining precise surgical execution with new technologies—prepectoral implant positioning, robotic flap harvest, and sensory nerve coaptation—to achieve durable, natural, and patient-centered reconstruction. Full article

This study investigates the impact of network structural characteristics on sustainable innovation performance within regional collaborative networks in China’s artificial intelligence (AI) industry. Provincial-level innovation networks were constructed and analyzed using social network analysis to trace their evolutionary pathways using patent application data from 2010 to 2024. The findings reveal that China’s AI innovation network has developed into a multi-tiered, polycentric structure with Beijing as the primary hub. An inverted U-shaped relationship was identified between network centrality, structural holes, and regional collaborative innovation performance at various developmental stages. The external institutional environment, particularly through government R&D subsidies and intellectual property protection, plays a significant moderating role, generally diminishing the effect of centrality while enhancing that of structural holes during the rapid expansion phase. Regional heterogeneity analyses confirmed these patterns in eastern, central, and western China, whereas in the northeast, only centrality showed a significant association with performance. By integrating network location theory with an institutional perspective, this study offers a dual-perspective framework for understanding how sustainable innovation ecosystems can be fostered through network governance and policy interventions. The results provide evidence-based policy implications aimed at enhancing collaborative innovation capacity, mitigating regional disparities, and advancing sustainable development. Full article

Since the introduction of advanced footwear technology (AFT) in 2017, numerous world records from 5 km to the marathon have been broken. Among these innovations, carbon-plated shoes have received particular attention. Previous research indicates improvements of 2–4% in running economy (RE), which translates into an approximate 1–2% improvement in running performance when running in these shoes. The rapid progression of performance has generated significant scientific interest; however, a clear understanding of the mechanisms driving the effectiveness of AFT remains limited. Despite widespread adoption and remarkable results, the mechanisms underlying the effectiveness of AFT are still not fully understood, which is why optimising its potential benefits continues to be an ongoing challenge. This review summarises current knowledge on AFT and critically evaluates the biomechanical and physiological mechanisms underlying their effects on RE and performance. It also highlights the interaction between shoe design features and individual biomechanics, supporting evidence-based approaches to footwear selection and training strategies tailored to athletes’ needs. A clearer understanding of these mechanisms may provide valuable insights for researchers, coaches, and athletes and help maximise the potential benefits of AFT. Full article

Italian inner areas face population decline, limited access to services and fragile infrastructure; however, the micro-mechanisms through which community practices generate tangible improvements often remain unclear. Still, local communitarian initiatives, such as those represented by ecovillages, can be an effective response to the ongoing process of marginalisation, becoming true living labs for place-based transitions. Through the analysis of the Torri Superiore Ecovillage (Imperia, Italy), a recognised and well-known good practice in the national and international ecovillage circuit, we want to find answers to three research questions: (RQ1) To what extent can an ecovillage act as a living lab for social innovation and ecological transition in inner areas? (RQ2) Which demographic and governance conditions enable territorial resilience and which ones block it? (RQ3) Which environmental practices generate locally significant improvements and with what limitations? Based on qualitative and interpretative evidence (2016–2025)—field observations, internal documents and testimonies—and on essential demographic indicators (ISTAT/SNAI), this study examines the Torri Superiore Ecovillage as a small-scale living lab. Torri Superiore and the surrounding municipalities are ageing and have reduced demographic bases; however selective immigration and heterogeneity of skills act as partial buffers. The governance of the Torri Superiore Ecovillage combines clear rules, participatory routines and coordination mechanisms, promoting problem solving while remaining sensitive to leadership burdens. The “bridging” between multiple actors enables terrace maintenance, local water resource management, agroecological practices, renewable energy adoption, waste prevention/composting and light mobility to achieve tangible environmental improvements on a small scale. We frame transferability as analytical (not statistical), specify the enabling conditions (sufficient active participants, stable routines, territorial management) and outline the relevant policy implications for SNAI classes and a lightweight longitudinal observatory. Full article

Technological flexibility is widely recognised as a driver of product innovation, yet its role in enabling the transition toward sustainable products remains insufficiently understood. This study addresses this gap by examining how technological flexibility shapes product–market strategies through two pathways: (1) technological flexibility—environmental scanning—product-market strategies (T–E–S) and (2) technological flexibility—environmental scanning—circular economy principles—product-market strategies (T–E–C–S). Using an abductive design and a survey of 300 medium and large manufacturing firms in Poland, we analyse eight dimensions of environmental scanning, seven circular-design principles, and four Ansoff-based strategic orientations. Non-parametric correlation tests and Kruskal–Wallis analyses, and post hoc tests show that technological flexibility significantly increases environmental scanning intensity. Yet only five macro-environmental segments trigger circular-design behaviour, and only two principles—repairability and waste minimisation translate into sustainable product strategies. Results reveal two competing logics: a commercial logic focused on market opportunities and an ecological logic centred on sustainable design. Their integration occurs only under high technological flexibility and scanning engagement. The study contributes new empirical evidence on mechanisms linking flexibility, scanning, circularity, and sustainability-oriented product innovation. Full article

Celiac disease (CeD) is a chronic, immune-mediated enteropathy triggered by dietary gluten in genetically susceptible individuals, with environmental and epigenetic factors also contributing to its pathogenesis. Once considered a rare pediatric malabsorptive disorder, CeD is now recognized as a systemic condition that can manifest with both gastrointestinal and extraintestinal symptoms across the lifespan. Although strict adherence to a gluten-free diet (GFD) remains the cornerstone of treatment, up to 30–40% of patients experience persistent symptoms and/or ongoing mucosal injury despite reported compliance. This therapeutic gap, combined with advances in molecular understanding of disease mechanisms, has driven the development of novel strategies targeting key pathogenic pathways. Intraluminal interventions include gluten-degrading enzymes and gluten-sequestering agents, while other approaches target tissue transglutaminase 2, induce antigen-specific immune tolerance, or modulate cytokine-driven inflammation, with particular emphasis on interleukin-15 (IL-15) signaling. Additional strategies aim to inhibit lymphocyte trafficking to the intestinal mucosa and enhance intestinal barrier function through zonulin modulation. Adjunctive therapies under investigation include nutraceuticals, microbiota-targeted interventions, and vaccine-based approaches. More recently, advanced experimental and computational platforms, such as human intestinal organoids, organ-on-chip systems, and machine learning–driven analytics, are being leveraged in efforts to accelerate translational research and support the rational design of precision medicine approaches. This narrative review synthesizes current evidence for therapies beyond the GFD, examines challenges in clinical implementation, and discusses how technological innovations may reshape the future therapeutic landscape of CeD. Full article

Gene conversion contributes to gene copy number changes, DNA mutations, and functional innovation and has been widely reported in three domains of life. However, it has hardly been described in Aspergillus, including industrially and commercially important or pathogenic fungi. Here, we revealed multiple sets of homologous genes located in a region of chromosome 1 of A. flavus, and its orthologous counterpart of A. oryzae. Phylogenetic analysis showed evidence of frequent gene (DNA) conversion between ectopic paralogs in each species, accompanied by prominent point mutations and DNA deletion (from several to hundreds of base pairs). At least two independent cases showed that the converted genes in A. oryzae have been repeatedly split into shorter genes by the introduction of stop codons, and then ectopic conversion rendered paralogous genes (regions) to have the same configuration of tandemly located new genes. Inference of nucleotide substitution and ancestral gene content showed that the conversion-affected regions have seen 3.48 times as many substitutions and 4–6 times as many gene losses compared to the non-affected regions. We predicted that a DNA loop between proximal regions, in the common ancestor and inherited by each species, facilitates ectopic gene (DNA) conversion and elevated rates of mutations and losses. Overall, we found that gene conversion proves to be a key factor resulting in genome instability, elevated gene evolutionary rates, and an effective avenue to produce new genes, likely leading to the speciation of two Aspergillus lineages. Full article

Most studies on countries’ innovation focus on its overall assessment, neglecting the interactions of its components. This article discusses the EU-27 countries’ innovation in each of its pillars, Framework conditions, Investments, Innovation activities, and Impacts, as defined in the European Innovation Scoreboard 2025. We quantitatively examine the connections among the innovation pillars and compare the results of the synthetic measure of innovation indicator with the SDG Index. First, we use the zero-unitarisation method to calculate four synthetic measures of countries’ innovation. Then, we perform canonical correlation analysis to examine the interconnections among the measures. Subsequently, we propose rankings and classifications of countries based on their innovation levels. The results show that, although the four pillars of innovation are interrelated, Framework conditions are of key importance, with their impact being most evident in relation to Impacts. Sweden, Finland, and Denmark were the leaders in pillars of innovation and sustainable development. However, we found that some countries (Poland, Slovakia, and Latvia) with lower innovation levels still had higher SDG Index values, placing them in the more sustainable group. The results of the study show that the relationship between innovation and sustainable development is not simple or linear. There are EU-27 countries that rank highly in one area but not the other. The results not only allowed for the assessment of the EU-27 countries in terms of innovation but also indicated precise relationships within this framework, linking innovations with sustainable development. Full article

Background: Pleural effusion (PE) is a frequent complication in patients with malignancies and is often associated with poor prognosis. Lung ultrasound (LUS) has become an indispensable bedside tool for detecting, characterizing, and guiding the management of pleural effusions. Methods: This narrative review summarizes the current evidence on the diagnostic performance of LUS for PE in cancer patients, emphasizing recent advances in functional ultrasound techniques. Results: B-mode LUS can detect small-volume effusions and estimate their volume. Sonographic features such as echogenicity, septations, and pleural abnormalities can help differentiate transudative from exudative effusions. Shear-wave elastography and contrast-enhanced ultrasound provide additional functional information on tissue stiffness and perfusion. This information may help distinguish between malignant and benign pleural lesions and facilitate targeted biopsy when cytology is nondiagnostic. Compared with computed tomography, LUS offers superior evaluation of juxtadiaphragmatic and pleural surface abnormalities. It facilitates safe, real-time thoracocentesis. Recent innovations, including improved quality, affordable handheld ultrasound systems and artificial intelligence-based analysis, are expected to further enhance diagnostic precision and accessibility. Conclusions: Although LUS is a sensitive and versatile tool for assessing PE in cancer patients, it has limited diagnostic accuracy in distinguishing between benign and malignant effusions. Advanced techniques, such as shear-wave elastography and contrast-enhanced ultrasound, may further support the differentiation of malignant and benign diseases. Ongoing technological advances are likely to enhance the diagnostic accuracy and accessibility of lung ultrasound. Full article

Deep brain stimulation (DBS) is an established therapy for motor symptom management in Parkinson’s disease (PD), yet emerging evidence suggests that its effects may extend beyond functional circuit modulation to include cellular and molecular mechanisms with potential neuroprotective significance. This review synthesizes current evidence on the neuroprotective mechanisms of DBS, with an emphasis on preclinical and clinical studies that highlight its effects on neuronal survival, trophic support, oxidative stress, inflammation, synaptic plasticity, and network homeostasis. Preclinical data indicate that DBS reduces dopaminergic neuron degeneration, enhances brain-derived neurotrophic factor (BDNF) signaling, preserves mitochondrial function, attenuates neuroinflammation, and fosters synaptic remodeling. Clinical studies provide convergent, though less definitive, evidence from imaging, fluid biomarkers, and long-term outcomes supporting potential disease-modifying effects. These findings underscore a shift in the conceptualization of DBS from purely symptomatic relief toward modulation of underlying pathogenic processes. DBS holds promise as a neuroprotective therapy for PD, but critical gaps remain in validating these mechanisms in patients. Future directions include the development of biomarker-driven longitudinal studies, refinement of adaptive stimulation strategies, integration with adjunctive disease-modifying strategies, and exploration of personalized approaches based on molecular and network signatures. By bridging mechanistic understanding with translational innovation, DBS may evolve into a precision therapy capable of altering the progression trajectory of PD. Full article

Globally, the consumption of foods containing probiotics has increased significantly due to their well-recognized health benefits, including the modulation of gut microbiota and immune function. However, despite strong scientific support, daily massive adherence to probiotic food remains limited, mainly because of their suboptimal sensory appeal and the huge variability in consumer expectations. Sensory attributes—flavor, aroma, texture, and appearance—strongly influence liking, purchase, and the habitual consumption necessary for probiotics to exert the physiological effects for which they are consumed. The present narrative review explores the complex, multidimensional interplay between sensory features, consumer perception, and probiotic efficacy. By integrating evidence from nutritional science, microbiology, sensory science, and behavioral psychology, we outline how technological innovation and sensory optimization can improve both product acceptability and adherence. We also discuss how cross-modal perception, the cultural framework, and labeling influence hedonic responses. Finally, we highlight emerging directions, such as sensory-driven strain selection, omics-based flavor profiling, and personalized sensory nutrition, as tools to bridge the gap between scientific efficacy and consumer satisfaction. Improving the sensory design of probiotic foods is pivotal to translate microbiome science into meaningful, sustainable dietary behaviors that support the nutrition–gut–immunity axis. Full article

Colorectal cancer (CRC) remains a major cause of morbidity and mortality worldwide, with its incidence and biological behavior influenced by both genetic and environmental factors. Emerging evidence highlights notable sex differences in CRC, with men generally exhibiting higher incidence rates and poorer prognoses, while women often display stronger immune responses and distinct molecular profiles. Traditional screening tools, such as colonoscopy and fecal-based tests, have improved survival through early detection but are limited by invasiveness, cost, and adherence issues. In this context, biosensors have emerged as innovative diagnostic platforms capable of rapid, sensitive, and non-invasive detection of CRC-associated biomarkers, including genetic, epigenetic, and metabolic alterations. These technologies integrate biological recognition elements with nanomaterials, microfluidics, and digital systems, enabling the analysis of biomarkers such as proteins, nucleic acids, autoantibodies, epigenetic marks, and metabolic or VOC signatures from blood, stool, or breath and supporting point-of-care applications. Electrochemical, optical, piezoelectric, and FET platforms enable label-free or ultrasensitive multiplexed readouts and align with liquid biopsy workflows. Despite challenges related to standardization, robustness in complex matrices, and clinical validation, advances in nanotechnology, multi-analyte biosensing with artificial intelligence are enhancing biosensor performance. Integrating biosensor-based diagnostics with knowledge of sex-specific molecular and hormonal pathways may lead to more precise and equitable approaches in CRC detection, selection of therapeutic regimes and management. Full article

Chagas disease (CD) remains a major global health challenge and requires standardized, multidisciplinary, and evidence-based clinical approaches. This article aims to present and systematize the model of clinical routines developed at the Clinical Research Laboratory on Chagas Disease (Lapclin-Chagas), INI/Fiocruz, for the initial evaluation and longitudinal follow-up of patients with chronic CD. The proposal is intended to serve as a replicable and adaptable framework for referral centers in both endemic and non-endemic settings. Using a descriptive qualitative design, institutional protocols, national and international guidelines, and expert consultations were analyzed to construct a comprehensive care model. The resulting protocol integrates diagnostic pathways (including dual serological confirmation and clinical staging), criteria for etiological treatment, and coordinated multidisciplinary follow-up involving cardiology, gastroenterology, pharmaceutical care, nutrition, psychology, and social support. Specific pathways are also presented for Trypanosoma cruzi (T. cruzi)/HIV coinfection, laboratory accidents, and monitoring of adverse reactions to benznidazole. By consolidating more than three decades of institutional experience into operational workflows, this proposal offers an innovative contribution to the organization of CD care and provides actionable guidance for health systems seeking to improve diagnostic accuracy, therapeutic adherence, patient safety, and long-term outcomes. Full article

Over the past decades, coronary revascularization has evolved dramatically with the introduction of bioresorbable scaffolds (BRSs), designed to provide temporary vessel support, elute antiproliferative drugs, and then fully resorb, ideally restoring natural vasomotion and eliminating long-term foreign-body reactions. Early enthusiasm for first-generation polymeric devices, such as the Absorb bioresorbable vascular scaffold, was tempered by increased rates of scaffold thrombosis and late adverse events, largely attributed to thick struts, suboptimal implantation techniques, and unpredictable degradation kinetics. Subsequent developments in polymeric (e.g., MeRes-100, NeoVas) and metallic magnesium-based scaffolds (e.g., Magmaris) have focused on thinner struts, improved radial strength, and refined resorption profiles. Clinical trials and meta-analyses, including ABSORB, AIDA, BIOSOLVE, and BIOSTEMI, reveal that optimized procedural strategies, especially the “PSP” approach (Prepare–Size–Post-dilate) and routine intravascular imaging, substantially reduce thrombosis and restenosis rates, aligning outcomes closer to those of contemporary drug-eluting stents (DESs). Nonetheless, challenges persist regarding inflammatory responses to degradation by-products, mechanical fragility in complex lesions, and patient selection. Ongoing innovations include hybrid polymer–metal designs, stimuli-responsive drug coatings, and AI-assisted imaging for precision implantation. While early-generation BRSs demonstrated both promise and pitfalls, next-generation platforms show steady progress toward achieving the dual goals of transient scaffolding and long-term vessel restoration. The current trajectory suggests that bioresorbable technology, supported by optimized technique and material science, may soon fulfill its original vision; offering safe, effective, and fully resorbable alternatives to permanent metallic stents in coronary artery disease. This review provides an updated synthesis of the design principles, clinical outcomes, and procedural considerations of drug-eluting bioresorbable scaffolds (BRSs). It integrates recent meta-analytic evidence and emerging insights on device mechanics, including the influence of strut thickness on radial strength and the potential role of non-invasive imaging in pre-implantation planning. Special focus is given to magnesium-based scaffolds and future directions in patient selection and implantation strategy. Full article