Search Results (19,089)

Laparoscopic cholecystectomy is now established as the worldwide gold standard for the treatment of benign gallbladder disease. Despite technical advancements, bile duct injury (BDI) remains a major concern, especially in patients with obesity. It is well known that in patients with a Body Mass Index (BMI) ≥ 30 kg/m², identification of Calot’s triangle and the achievement of the Critical View of Safety (CVS) during laparoscopic cholecystectomy (LC) are made more challenging due to excessive visceral adiposity and concomitant hepatic steatosis reducing the workspace. Near-Infrared Fluorescence Cholangiography (NIRF-C) with Indocyanine Green (ICG) has emerged as an innovative, safe and effective technique to visualize the biliary anatomy and minimize the risk of iatrogenic BDI. However, its specific benefit in patients with obesity remains under-discussed compared to the general population. The main aim of this narrative review is to evaluate whether the intraoperative use of ICG in patients with obesity may reduce operative times and the risk of BDI. A focused review of the literature is performed on articles from 2010 to 2025 published on PubMed, Scopus and Web of Science. The application of ICG fluorescence in LC for patients with obesity represents a tangible clinical advantage, not only for anatomical identification and significant improvement of procedural efficiency, but also for the reduction in operative time. Full article

Plants must constantly adapt to biotic and abiotic stressors, which the global climate change crisis has intensified. To monitor plant health and predict their ability to face these challenges, various target molecules, such as hormones, glucose, and reactive oxygen species, are used as proxies for their physiological status. This review provides a systematic assessment of the current state of biosensor technology, an innovative analytical approach designed for in situ, minimally invasive, and real-time monitoring. Using the PICO (Problem, Intervention, Comparison, and Outcome) strategy, relevant research papers were identified. The review highlights how biosensors can detect physiological responses to stress before visual symptoms manifest, offering a significant advantage over traditional, often destructive, laboratory techniques, like gas chromatography–mass spectrometer (GC-MS) or high-performance liquid chromatography (HPLC). These advancements aim to improve precision agriculture and forestry management by providing sustainable methods to assess resilience in changing environments. Finally, the challenges of translating research from model organisms to complex woody species and choosing the correct target are discussed, and future perspectives, including the integration of biosensors with Artificial Intelligence-driven predictive models for large-scale environmental monitoring, are outlined. Full article

Industrial chains in agriculture are currently fragmented and do not support developing resource-based competitive advantages. This is true under the Big Food Framework’s strategic orientation. This research seeks to develop a new analytical framework for evaluating pathways to the integration of agricultural industrial chains and their impact on the performance of companies engaged in food processing in Xinjiang. A mixed-method approach, employing both an exploratory and sequential design, will be used to do this. The primary method of data collection for this study is the case study method, along with the questionnaire method involving 145 agricultural enterprises. From these data, structural equation modeling (SEM) will be used to test the paths of causation among cognitive managers of firms who have implemented the BFF. Evidence will be presented to demonstrate the relationship among three types of integration (vertical, horizontal, and lateral) in the agricultural industrial chain, dynamic capabilities, and company performance. Additionally, network topology and optimization simulations will be conducted to determine how effectively structures are organized in training the respective companies. Important findings revealed in this research include the following: The managerial cognition constructs offered by BFFs play a key role in enhancing the depth and structural balance of industry chain integration. There were complementary performance effects found, and they are related to vertical integration achieving operational efficiency and financial efficiency; horizontal integration improving market competitiveness and brand competitiveness; and lateral integration facilitating innovative growth. Dynamic capabilities are a significant mediating mechanism linking institutional support and digital capability with the depth of integration across different modes of integration. The findings from network optimization suggest that there is a positive effect of balanced connectivity across the different dimensions of integration on overall system efficiency and reduced structural inefficiencies. Based on these findings, the authors recommend that organizations establish governance mechanisms that facilitate coordinated connectivity; strengthen adaptive capabilities within the firm; and promote balanced integration across industrial networks. Future researchers should consider applying these findings to conducting longitudinal studies on network evolution; integrating sustainability measures as part of their analysis; and conducting comparative validation studies across regions or industry systems. Full article

This study addresses the growing necessity to understand how artificial intelligence (AI) competency and soft skills jointly influence organizational innovation and performance in the era of digital transformation. Despite the rapid adoption of AI technologies across industries, organizations continue to face significant challenges in effectively integrating technical AI capabilities with essential human-centric soft skills such as communication, adaptability, and leadership. This gap often limits the realization of AI-driven value and sustainable competitive advantage. The primary challenge in this research area is the lack of comprehensive models that simultaneously examine AI competency and soft skills within a unified framework, particularly in emerging economies where digital maturity varies widely. Existing studies tend to focus either on technical competencies or behavioral factors in isolation, leading to fragmented insights. To address these challenges, this study proposes a novel integrated research model that examines the combined effects of AI competency and soft skills on innovation outcomes and organizational performance. The model is empirically validated using structural equation modeling (SEM), providing robust evidence of the interrelationships among key constructs. The findings reveal that both AI competency and soft skills significantly contribute to innovation capability, which in turn enhances organizational performance. The study offers important theoretical and practical implications by bridging the gap between technical and human dimensions of AI adoption, thereby providing a more holistic understanding of digital transformation success. Full article

Blood glucose level (BGL) prediction, by providing early warnings regarding unsatisfactory glycaemic control and maximising the amount of time BGL remains in the target range, can contribute to minimising both acute and chronic complications related to diabetes. This paper aims to provide an overview of data-driven approaches for BGL prediction in type 1 diabetes mellitus (T1DM). This review summarises different aspects of developing and evaluating data-driven prediction models, including model strategy, model input, prediction horizon, and prediction performance. It also examines applications of recent artificial intelligence (AI) techniques, including deep learning, transfer learning, ensemble learning, and causal analysis in the management of T1DM. Recent studies indicate that machine learning approaches often outperform classical time-series forecasting models in BGL prediction, particularly when using multivariate inputs. These findings also highlight the potential of advanced AI methods to improve prediction accuracy. Moreover, applying appropriate statistical analyses is essential to enable valid comparisons between different BGL prediction models, especially given the considerable inter-individual variability among people with T1DM. The development of efficient methods for integrating affecting variables into BGL prediction requires further research. Given the promising performance of advanced AI techniques and the rapid growth of AI innovation, continued exploration of cutting-edge AI strategies will be crucial for further improving BGL prediction models. Full article

Rising production costs have increased interest in lower-cost, non-inversion crop establishment systems in Ireland, yet uptake remains relatively limited. Growers’ perceptions of relative performance of innovations compared to current practice are key determinants of adoption. We surveyed 154 Irish arable growers (77 plough-based, 59 min-till, 18 direct drill) to assess perceived performance of min-till and direct drill across multiple parameters relative to ploughing to identify potential barriers to adoption. Respondents rated impacts on Likert scales; analyses summarized response distributions and between-system differences. For example: >30% of min-till growers believed min-till winter cereal yields exceed ploughing, compared with 0% of plough and <10% of direct drill growers. Growers generally favoured their own establishment system, consistent with adoption theory. Potential barriers to non-inversion adoption included perceived lower establishment reliability, crop performance concerns (especially spring crops), and anticipated increases in weed pressure, herbicide reliance, and herbicide resistance development risk. Several perceptions diverged from the Ireland-relevant literature, revealing both knowledge gaps (notably establishment stability and winter/spring crop performance of establishment systems) and misperceptions (including establishment system on soil structure). Targeted research to address knowledge gaps, combined with focused, grower-centred knowledge exchange, is required to support evidence-based evaluation and sustainable adoption of establishment systems in Ireland. Full article

The production of fiber-reinforced polymer composites using 3D printing technology offers significant potential and opportunities for industrial applications. However, current dimensional limitations in 3D printing necessitate the use of joining techniques to obtain larger components. Recently, innovative strategies such as friction stir spot welding (FSSW) have attracted considerable attention for joining polymer composites due to their ability to produce strong joints with relatively low heat input (solid-state welding). Nevertheless, it is important to understand how the fibers present in fiber-reinforced polymer composites influence material flow and welding performance during the FSSW process. In this study, glass fiber-reinforced polylactic acid (PLA-GF) composite samples produced using a 3D printer were joined by means of FSSW. Five different tool rotational speeds (900, 1200, 1500, 1800, and 2100 rpm) and three different plunge rates (10, 20, and 30 mm/min) were employed during the welding process. Mechanical tests were performed on the welded joints to investigate the relationship between the welding parameters and the resulting mechanical properties. In addition, microstructural analyses were conducted to examine the formation of welding defects. The results revealed that three distinct zones were formed in the material after the FSSW process: the stir zone, mixed zone, and shoulder zone. Defects were observed in the mixed zone of the samples exhibiting relatively lower mechanical properties. The highest tensile force was achieved at a plunge rate of 20 mm/min and a rotational speed of 900 rpm. The highest bending force, on the other hand, was obtained at a plunge rate of 30 mm/min and a tool rotational speed of 2100 rpm. Full article

In order to protect the high-sensitivity optical lens of the “magnetic field and velocity field imager” in extreme deep space environments, this paper proposes a new type of dual redundant planetary differential lens cover drive mechanism. In view of the critical vulnerability that traditional single-motor direct drive is prone to sudden mechanical jamming and catastrophic single-point failure (SPF) in severe tasks such as Jupiter exploration, this study constructs a “dual input single output (DISO)” rigid decoupling architecture from the perspective of physical topology. Through theoretical analysis and kinematic modeling, the adaptive decoupling mechanism of the two-degree-of-freedom (2-DOF) system under unilateral mechanical stalling is revealed. Dynamic analysis shows that in the nominal dual-motor synergy mode, the system shows a significant “kinematic load-sharing effect”, thus greatly reducing the sliding friction and gear wear rate. In addition, under the severe dynamic fault injection scenario (maximum gravity deviation and sudden jam superposition of a single motor), the cold standby motor is activated and the dynamic takeover is quickly performed. The high-fidelity transient simulation based on ADAMS verifies that although the fault will produce transient global torque spikes and pulsed internal gear contact forces at the moment, all extreme dynamic loads remain well within the structural safety margin. The output successfully achieved a smooth transition, which is characterized by a non-zero-crossing velocity recovery. This research provides an innovative theoretical basis and a practical engineering paradigm for the design of high-reliability fault-tolerant mechanisms in deep space exploration. Full article

The field of nanoparticle-based biotechnology has undergone substantial advancement, characterized by progress in targeted drug delivery systems, the development of innovative diagnostic and imaging platforms, the expanded adoption of environmentally sustainable (“green”) synthesis approaches, and an increasing emphasis on the integration of emerging technologies such as artificial intelligence and nanorobotics. Conventional nanoparticle synthesis often involves toxic reducing agents; however, recent advances promote eco-friendly green synthesis methods utilizing biological systems such as bacteria, fungi, algae, yeast, plants, and actinomycetes. These biological approaches are safe, sustainable, cost-effective, and capable of producing highly stable Nanoparticles (NPs). The interaction of nanomaterials with biological systems is crucial for developing intracellular and subcellular drug delivery technologies with minimal toxicity, governed by nano–bio interface mechanisms such as cellular translocation, surface wrapping, embedding, and internal attachment. Key factors influencing NP behavior include morphology, size, surface area, surface charge, and ligand chemistry. Magnetic nanoparticles, particularly iron-based forms, exhibit unique superparamagnetic properties that are strongly influenced by particle size, as explained by the Néel relaxation mechanism, in which thermal energy induces flipping of magnetic moments. Nanoparticles demonstrate diverse modes of action, including antimicrobial activity, reactive oxygen species (ROS)-induced cytotoxicity, genotoxicity, and plant growth promotion. NP performance and biological effects are strongly dependent on their size, shape, dosage, and concentration. This critical review article aims to elucidate evolution, classification, preparation methods, and multifaceted applications of nanoparticles Full article

We introduce the Normalising Flow GARCH (NF-GARCH), a two-stage hybrid framework that enhances traditional GARCH models by replacing restrictive parametric innovation distributions with learned densities via normalising flows. Our approach preserves the interpretability of standard variance dynamics while addressing the common issue of innovation misspecification. In the first stage, we estimate standard GARCH variants (sGARCH, TGARCH, and gjrGARCH) to extract standardised residuals. In the second stage, a Masked Autoregressive Flow learns the underlying residual distribution, with samples from the flow subsequently driving the GARCH recursion for out-of-sample forecasting. Evaluated on 13 daily financial series (six FX pairs and seven equities), NF-GARCH demonstrates systematic, statistically significant improvements in forecast accuracy for skewed-t baselines. Wilcoxon signed-rank tests confirm superior performance specifically for gjrGARCH-sstd and sGARCH-sstd specifications. While the framework offers enhanced flexibility and generative realism, we observe that computational overhead is increased, and the log-variance specification of eGARCH exhibits instability when paired with flow-based innovations. These results suggest that while NF-GARCH effectively captures empirical tail behaviour in univariate settings, future research should explore conditional flow architectures and multivariate extensions to account for time-varying innovation shapes. For risk management, gains are most relevant where skewed-t baselines are used and where closer residual realism supports scenario analysis; effect sizes remain modest relative to model risk and implementation cost. Full article

Assessing genotoxicity, specifically gene mutations and chromosomal aberrations, is fundamental to chemical risk assessment. Notably, the early identification of an aneugenic mechanism is of crucial importance, allowing, in principle, for a threshold-based risk assessment approach. To investigate this issue while pushing towards innovation in risk assessment by leveraging New Approach Methodologies, in silico approaches stand out as a particularly promising avenue. Building on these premises and given the lack of QSAR models for aneuploidy in the public domain, the present study exploited the genotoxicity-relevant alert lists implemented in the OECD QSAR Toolbox to base the investigation of structure-activity relationships for aneuploidy. To address the lack of relevant structured data resources, a dataset of 65 confirmed aneugenic substances was specifically curated and designed for the study. The results highlighted widely differing performances among the various profilers, confirming a general limited discriminatory power for aneuploidy. On the other hand, a granular analysis of the results from individual structural alerts enabled the successful isolation of some features associated with the aneugenic mode of action. Moreover, a subset of tubulin-binding chemicals was investigated to determine whether targeting a specific protein improves the characterization of toxicological alerts. The findings provide a refined definition of specific toxicity determinants for tubulin binders and serve as a promising tool for early hazard assessment, potentially informing relevant AOPs. While the computational approach appears promising, the overarching challenge that emerges is the limited availability of well-curated experimental data. In fact, reliable data on aneuploidy are scarce and fragmented across the literature. Furthermore, existing compilations of micronucleus study results are often complicated by conflicting interpretations. Full article

The classic design of the Practical Byzantine Fault Tolerance (PBFT) protocol relies on a centralized primary node, which not only creates a performance bottleneck but also introduces severe data censorship risks, threatening the data integrity and security of Edge Computing networks. To address this challenge, this paper proposes DC-PBFT (Decoupled PBFT), a censorship-resistant consensus protocol for Edge-Internet of Things (Edge-IoT) environments. The core innovation of DC-PBFT lies in the decoupling of the Proposer and Primary roles, supplemented by Verifiable Random Function (VRF)-based dynamic role rotation, which fundamentally eliminates the arbitrary power of a single node. Building on this, the protocol introduces a parallel group consensus mechanism: an elected Consensus Committee (CC) composed of Active Edge Nodes leads the consensus, while an independent Replica Network (RN) performs parallel validation. When a disagreement arises, the protocol triggers a global disagreement arbitration process involving all nodes to guarantee final consistency and attribute fault. To ensure long-term incentive compatibility, we also designed a hybrid election mechanism combining Proof-of-Stake and dynamic reputation, along with corresponding economic incentives and a tiered penalty system. Theoretical analysis proves that DC-PBFT satisfies Consistency and Liveness, and achieves strong censorship resistance guarantees. Simulation results demonstrate that DC-PBFT’s scalability significantly outperforms PBFT and RepChain; its reputation mechanism effectively improves long-term performance under sustained Byzantine attacks; and, compared to asynchronous censorship-resistant protocols like HoneyBadgerBFT, DC-PBFT achieves censorship resistance with over 45% lower transaction confirmation latency. Full article

The present study provides a high-frequency empirical assessment of the financial performance, volatility, and market integration of thematic sustainability-oriented equity funds, focusing on clean energy and environmental innovation indices. Specifically, the study compares the financial performance of representative thematic green equity funds, such as ICLN and QCLN, and an emerging-market benchmark (ECON) with conventional developed-market indices (SPY, QQQ, GSPC, and XLE) using daily stock prices from 2010 to 2025. The analysis employs a transparent and replicable framework based on daily logarithmic and cumulative returns and incorporates the compound annual growth rate (CAGR), Sharpe and Sortino ratios, beta estimation, correlation analysis, and maximum drawdown. The research frequency is appropriate for a thorough analysis of short-term market structures and performance. The results indicate that sustainability-oriented equity indices exhibit higher volatility, deeper drawdowns, and greater sensitivity to broad market movements than conventional benchmarks. Sustainability-focused equity indices that emphasize clean energy exhibit higher market sensitivity (betas above 1) and strong correlations with traditional equity indices. Correlation and beta estimates suggest a high degree of integration with traditional equity markets, implying limited diversification benefits within an equity-only framework. Periods of relative outperformance appear to be associated with favorable policy conditions and energy market dynamics, but are not consistently sustained over the sample period. In addition, the overall results suggest that sustainability investments generate substantial environmental and social externalities. Risk-adjusted performance measures suggest weaker historical performance over the sample period relative to conventional benchmarks. These findings should be interpreted as a comparative historical assessment rather than a structural risk model. From a policy perspective, the findings suggest that stable and credible regulatory frameworks, including long-term climate policy support and investment-enabling institutions, may be important for improving the financial resilience and long-term viability of green equity instruments. From a sustainability transition perspective, the observed volatility and market dependence of sustainability-oriented equity indices may constrain their effectiveness as standalone market-based financing mechanisms without complementary institutional and policy support. Full article

In today’s energy landscape, defined by the growing demand for sustainable energy generation technologies and the parallel need to advance internal combustion engine (ICE) architectures toward cleaner and more efficient solutions, the adoption of Free-Piston Linear Generator (FPLG) engines emerges as a highly promising approach. This innovative system enables the direct conversion of combustion-induced piston motion into electrical energy, eliminating the need for traditional crankshaft and connecting rod mechanisms. The FPLG concept facilitates efficient utilization of a broad spectrum of fuels—including methane, ethanol, LPG, gasoline, biodiesel, and hydrogen—by supporting variable compression ratio operation. This feature enhances operational flexibility and fuel adaptability, positioning the technology as a viable candidate for future energy transition scenarios. The absence of rotating mechanical components significantly reduces frictional losses, contributing to an overall increase in system efficiency. To accurately characterize and optimize engine performance, an extensive series of one-dimensional (1D) numerical simulations was performed under both free and controlled operating conditions. The resulting data enabled the development of semi-empirical models capable of predicting the dynamic behavior of the engine across a wide range of working scenarios. Finally, through a detailed parametric analysis, the optimal operating conditions were identified to maximize both net electric efficiency and electrical power output. These findings provide a solid ground for the design and implementation of FPLG engine systems in advanced power generation applications. Full article

Images of wind turbine blades captured by drones often feature complex backgrounds, and small targets such as minor defects or images have low resolution, leading to reduced recognition rates. To address environments with complex feature backgrounds, this paper proposes the PPS-MSDeim model. Based on the lightweight end-to-end detection framework DEIM-N, it introduces three core innovations to tackle the challenge of detecting small, irregular defects on wind turbine blades against complex backgrounds. First, we design an inverted multi-scale deep separable convolutional module (MDSC). After compressing channels via a bottleneck layer, it concurrently processes 3 × 3, 5 × 5, and 7 × 7 inverted deep separable convolutions. By first fusing channel information and then extracting multi-receiver-field spatial features, this approach enhances the ability to characterize morphologically variable defects while reducing computational overhead. The MDSC is then embedded into the backbone network HGNetv2. Second, we construct a Multi-Scale Feature Aggregation and Diffusion Pyramid Network (MFADPN). Through a Multi-Scale Feature Aggregation Module (MSFAM), it directly fuses features from layers P2 to P5, achieving deep integration of high-level semantics and low-level details. Combining dilated convolutions with expansion ratios of 1, 3, and 5 captures multi-level context, and a Sobel edge branch is introduced to enhance defect contours; subsequently, a feature diffusion operation is performed to distribute the enhanced features back to each level, shortening information paths and preventing signal decay; simultaneously, a high-resolution detection head is added to P2 and the P5 head is removed to improve sensitivity for small object detection. Finally, we propose the PPSformer module to replace the original Transformer encoding layer. It uses patch embedding to convert images into sequences and introduces a multi-head probabilistic sparse self-attention mechanism that focuses only on key-value pairs during attention computation. This design efficiently captures irregularly varying feature information and globally detects data anomalies induced by external defects. This study uses real engineering data sets, and the results show that PPS-MSDeim, based on DEIM, increased mAP@0.5 by 6.7%, reaching 95.1%. mAP@0.5–0.95 increased by 12.0%, reaching 70.1%. This indicates that the proposed method has a significant advantage in detecting defects in wind turbine blades. Full article