Search Results (1,213)

Titanium-based dental implants have evolved significantly, with the development of binary alloys like Ti-15Zr (Roxolid™) representing a pivotal advancement in mechanical performance. Current research focuses on biomimetic surface engineering to further accelerate osseointegration and optimize bone regeneration, particularly in clinically compromised sites. This review constitutes a narrative synthesis of how these strategies replicate the bone extracellular matrix (ECM) through a holistic framework of architectural, mechanical, and biochemical integration. A structured literature search across PubMed, Scopus, and Web of Science (2010–2026) identified relevant studies focusing on the synergy between Ti-15Zr substrates and surface modifications. Evidence confirms that the high fatigue strength of Roxolid™ alloys provides an ideal foundation for advanced, hierarchical surface engineering without compromising structural integrity. This strategy utilizes macro-topography for primary stability, nano-topography for protein adsorption, and bio-functionalization (e.g., RGD peptides and osteogenic ions) to direct mesenchymal stem cell (MSC) differentiation. This synergy accelerates the transition from passive to active osseointegration, effectively bridging the “biological gap” during early healing. Biomimetic engineering transforms implants into instructive biological platforms, improving outcomes for patients with compromised bone quality and facilitating predictable immediate loading protocols. Full article

The development of 3D printing high-impact denture bases is challenging, as materials exhibiting both high flexural strength/modulus and fracture toughness are required. Nowadays, most of the commercially available 3D printing denture bases contain significant amounts of crosslinking monomers and therefore behave as brittle materials. In this contribution, urethane dimethacrylate DMA1/(octahydro-4,7-methano-1H-indenyl)methyl acrylate (OMIMA) 1/1 (wt/wt) formulations containing a poly(ε-caprolactone)-polydimethylsiloxane-poly(ε-caprolactone) (PCL-PDMS-PCL) triblock copolymer (BCP1) and fumed silica SiO₂-NPs were evaluated for DLP 3D printing of fracture-tough denture bases. The post-curing step was performed at various temperatures (RT, 60 °C, 80 °C, 100 °C and 120 °C). This parameter was shown to strongly influence the T_g and mechanical properties of 3D printed materials. A post-curing temperature of 100 °C was found to be ideal. Under these conditions, 3D printed materials exhibiting excellent mechanical properties were successfully obtained. Furthermore, the amounts of BCP1 and SiO₂-NPs were varied. The formulation containing 8.0 wt% of BCP1 and 10.0 wt% of SiO₂-NPs (FS = 67.5 ± 1.3 MPa, FM = 2450 ± 71 MPa, K_max = 2.11 ± 0.06 MPa m^1/2, W_f = 1109 ± 19 J m⁻²) was able to fulfill the ISO 20795-1:2013 requirements in terms of flexural strength (FS)/modulus (FM) and fracture toughness for denture bases with improved impact resistance (FS > 65 MPa, FM > 2000 MPa, K_max > 1.9 MPa m^1/2, W_f > 900 J m⁻²). This material showed better performance than the commercially available formulations Printodent^® GR-14.2 denture HI (FS = 69.2 ± 1.8 MPa, FM = 2153 ± 76 MPa, K_max = 0.82 ± 0.04 MPa m^1/2, W_f = 79 ± 10 J m⁻²) and Lucitone Digital Print^TM 3D denture base (FS = 56.7 ± 1.9 MPa, FM = 2144 ± 12 MPa, K_max = 1.92 ± 0.09 MPa m^1/2, W_f = 1272 ± 177 J m⁻²). Full article

Lost circulation of wellbore fluids within fissured zones constitutes a primary factor contributing to increased non-productive time (NPT) and restricted rate of penetration (ROP). Conventional gel-based lost circulation materials (LCMs) inherently suffer from a tradeoff between pumpability and in situ fracture retention, and they lack a design methodology quantitatively correlated with drilling engineering parameters. In this study, a shear-responsive gel with a dual physically crosslinked network—combining hydrophobic association and Fe³⁺-mediated ionic coordination—was prepared through a single-step water-based radical polymerization process, utilizing commercially available monomers. By systematically tuning the hydrophobic monomer and Fe³⁺ contents, the gel’s fracture-sealing efficacy, autogenous healing ability, and shear rheological characteristics were evaluated, establishing a quantitative correlation between the critical shear rate and drilling parameters. The empirical data demonstrate that with an increase in the hydrophobic monomer dosage from 0.4 wt% to 1.2 wt%, the critical shear rate decreases from 22.5 s⁻¹ to 8.6 s⁻¹, exhibiting an exponential decay relationship. The optimized formulation, G0.8F0.5, demonstrates a low initial viscosity of 245 mPa·s under high shear conditions, which surges to 6180 mPa·s at a shear rate of 14.2 s⁻¹, achieving a thickening factor of 29.4. Upon incubation at 80 °C for a duration of 12 h, the formulated gel restores 94.9% of its mechanical tensile strength and 96.3% of its fracture strain, whereas the Fe³⁺-free control sample fails to heal. In dynamic plugging tests using a 3 mm fracture plate, G0.8F0.5 achieves a breakthrough pressure of 12.8 MPa with a minimal fluid loss of 98 mL. The LCM forms a monolithic gel block positioned at the middle-to-rear section of the fracture, outperforming conventional gel counterparts. Drilling hydraulics simulations reveal that deploying this gel reduces the annular equivalent circulating density (ECD) by 0.06 g/cm³. Furthermore, under idealized conditions, this approach is calculated to enhance the ROP by approximately 26%. The proposed molecular design of a shear-responsive, dual physically crosslinked network provides a viable technical pathway for quantitatively tailoring the shear-responsive properties of while-drilling LCMs. Full article

Most adsorbent materials typically face difficulties such as poor blood compatibility, weak mechanical strength, and high cost. In this study, oxidized 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) was used to obtain cellulose nanofiber (TOCN), and cellulose beads were prepared using a drop curing method. The structure, adsorption properties, and blood compatibility of the prepared beads were thoroughly investigated. The TOCN beads exhibit a uniform, nanometer-scale, three-dimensional porous structure. With increasing carboxyl content, after adsorption of TOCN beads, the bilirubin concentration in rabbit plasma decreased from 0.03 to 0.0089 mg mL⁻¹ within 90 min, which is significantly lower than the average bilirubin concentration in humans (about 0.01 mg mL⁻¹), and the bilirubin concentration decreased by about 70%. The results illustrated the excellent blood compatibility, self-anticoagulant ability, and superior toxin removal capabilities of the TOCN beads, highlighting their potential as an ideal blood purification adsorbent. Full article

Detecting wall damage is crucial for ensuring building safety, as undetected cracks may result in serious structural issues. Early inspections are therefore critical to maintaining structural integrity and avoiding expensive repairs down the line. However, building cracks exhibit highly diverse characteristics. Fine, surface-level cracks require precise local information for reliable identification. Large cracks demand global contextual information to be properly recognized. Convolutional neural networks specialize in capturing detailed local features, making them ideal for detecting small cracks. Transformers are adept at modeling long-range interactions and global pixel correlations, which are crucial for segmenting large and intricate crack structures. Despite these complementary strengths, most existing approaches rely exclusively on either CNN-based or Transformer-based encoders. They often fail to balance local detail and global context, leading to incomplete or inaccurate segmentation results. To overcome this challenge, we introduce DEF-Net, an innovative dual-encoder architecture. This model combines the strengths of CNNs and Transformers. A CNN encoder is employed to extract rich local representations. A Transformer encoder is used to provide global structural context. To fully integrate the complementary features from both encoders, we present an attention-based feature fusion module that aligns and merges features at different levels, boosting the network’s overall representation ability. This design allows DEF-Net to precisely identify both minor, intricate cracks and large, complicated ones across varied conditions. Comprehensive experiments on the CrackSeg9k and DeepCrack datasets show that DEF-Net consistently surpasses existing methods, delivering its exceptional segmentation performance and generalization ability. These findings underscore the value of integrating local and global modeling for assessing structural damage and lay a solid groundwork for future advancements in intelligent crack detection. Full article

High-intensity 5 km running offers an ideal framework to analyze the organism’s multidimensional responses. Since previous research primarily analyzed isolated aspects of fatigue, this study aimed to examine the integrated acute neuromuscular, metabolic, and perceptual responses to a 5 km run. Twenty-one recreational male runners participated. Pre- and post-race assessments included body composition, blood lactate, m. rectus femoris ultrasound thickness, quadriceps maximal voluntary isometric contraction (MVIC), heart rate, perceived exertion (Borg CR10), and 5 km finish time. Statistical analysis was performed in the Jamovi software, utilizing descriptive statistics, the Shapiro–Wilk test of normality, the Wilcoxon signed-rank test with effect size calculation, and Spearman’s correlation coefficient, at a significance level of p < 0.05. Post-race measurements revealed a significant decrease in quadriceps MVIC (pre: 305 ± 99 N vs. post: 259 ± 88 N; p = 0.002) and an increase in blood lactate (pre: 0.8 ± 0.4 vs. post: 6.9 ± 1.4 mmol/L; p < 0.001), alongside high average heart rates (165 ± 16 bpm). However, ultrasound-assessed muscle architecture remained unchanged. The 5 km run induced pronounced neuromuscular and metabolic fatigue. Unchanged muscle architecture suggests that acute strength decline is primarily mediated by metabolic and neural mechanisms, rather than immediate structural–morphological factors. These findings highlight the value of an integrated assessment approach for understanding acute fatigue responses following high-intensity 5 km running and may contribute to more precise training-load prescription and recovery monitoring in recreational runners. Full article

This review synthesizes findings from more than 100 journal articles, reports, and design standards on the design, simulation, and testing of steel beam-to-column connections, with emphasis on semi-rigid bolted extended end-plate (EEP) joints. The core objective of this study is to highlight the critical importance of accurately capturing this semi-rigid behavior, given the significant implications of improper modeling for the global response, safety, and design reliability of steel frames. While connections are often idealized as fully rigid or pinned, EEP connections typically exhibit a semi-rigid response governed by nonlinear moment–rotation (M–θ) behavior. The reviewed literature is organized around: (i) mechanical response and key failure mechanisms (end-plate yielding, bolt fracture, and prying action); (ii) analytical and numerical prediction methods, including component-based models and finite-element approaches capable of representing contact, bolt pretension, and cyclic degradation; and (iii) system-level implications for steel frames. Approaches used in major standards (AISC and Eurocode 3) for classifying connection stiffness and strength are compared, and experimental programs are summarized to identify the dominant parameters controlling resistance, ductility, and failure mode. Translating these component-level findings to the structural-system level, the review highlights how appropriately detailed semi-rigid EEP connections can enable moment redistribution, reduce member demands, and support stable inelastic deformation under seismic actions. Key research gaps include three-dimensional and multiaxial loading, impact and other high-rate actions, and the performance of alternative materials such as stainless steel. Full article

Bipolar vessel sealing systems are widely used in surgery, yet their effectiveness varies depending on the histological composition of the target vessel. In particular, the influence of elastin on seal stability is not well understood. Porcine carotid arteries, which show a pronounced proximal–distal elastin gradient, provide an ideal model for systematic analysis. In this study, fresh porcine carotid arteries were divided into three segments based on vessel diameter (<5 mm, 5–7 mm, >7 mm). Histological EvG staining was used to quantify elastin and collagen content. All vessels (n = 8 per group) were sealed using a bipolar marSeal^® 5 plus device, followed by burst pressure testing and peel force measurements. Elastin content increased significantly from peripheral to central segments (9% → 25% → 42%; p < 0.001), while collagen content remained constant (22 ± 2%). In parallel, seal stability decreased markedly: burst pressures dropped from 723 mmHg to 240 mmHg and to 31.5 mmHg (p < 0.001). Peel forces showed the same trend (1.75 ± 0.07 N → 0.65 ± 0.03 N → 0.26 ± 0.11 N; p < 0.001). Wall thickness showed no proportional relationship to seal quality. Interestingly, the sealing performance of bipolar systems seems to be greatly influenced by the histological structure of the vessel wall. A high elastin content—rising from 9% to 42% along the carotid artery—was associated with a reduction in burst pressure and peel strength. These findings highlight the need to consider tissue composition when selecting sealing methods and support the development of adaptive energy delivery technologies. Full article

Reinforced concrete (RC) infilled frames are widely used structural systems; however, seismic design provisions often idealize masonry infill as non-structural, leading to uncertainty in performance assessment. This study experimentally and numerically investigates the role of unreinforced masonry infill in RC frames, focusing on load-transfer mechanisms, strain evolution, and energy redistribution. Two 2/3-scale single-bay, single-storey RC frames (bare and fully infilled) were tested under constant axial load and quasi-static reversed cyclic lateral loading. Reinforcement strain gauges were used to capture local deformation demands, and a nonlinear macro-model was developed and validated against experimental results. Results show that the presence of masonry infill significantly increases ultimate strength, initial stiffness, and energy dissipation capacity, in comparatively more brittle post-peak cyclic behavior and accelerated stiffness degradation that leads to more abrupt post-peak degradation. Strain measurements provide clear evidence of a staged interaction mechanism: at low drift levels, the infill governs lateral resistance through diagonal compression strut action, limiting reinforcement demand in the frame; with increasing drift, progressive cracking and crushing of the infill promote a gradual transfer of forces to the RC frame, reflected by increasing reinforcement strains and stiffness degradation. At higher drift levels, the system transitions to frame-dominated behavior with localized strain concentration and shear failure at column bases or joints. These findings demonstrate that infill significantly modifies structural response and highlight the importance of incorporating strain-based mechanisms in the seismic assessment of infilled RC frames. Full article

This study produced and analyzed composite membranes composed of polysulfone (PSf), polyvinylpyrrolidone (PVP) and Metal–Organic Framework (ZIF-8) for treating effluent generated by the Batik industry. The incorporation of ZIF-8 was performed to enhance membrane efficiency. The findings indicated that ZIF-8 markedly enhanced hydrophilicity and pure water flux of membranes. The M-0.5 membrane containing 0.5 g of ZIF-8 demonstrated superior performance, with a water contact angle of 49.4° and a porosity of 83.5%. In contrast, the ZIF-8-free membrane (M-0) displayed a water contact angle and porosity of 66.3° and 76.7%, respectively. These combined characteristics enabled the M-0.5 membrane to achieve the highest pure water flux of 197.1 L m⁻² h⁻¹ at 5 bar. All membranes attained complete total suspended solids (TSS) rejection at 100% efficiency. Turbidity rejection rates ranged from 75% to 92%, whilst color rejection rates ranged from 65.7% to 87.6%. The maximum chemical oxygen demand (COD) rejection observed was 57.9%, achieved by the M-0.25 membrane (0.25 g of ZIF-8) at an operational pressure of 4 bar. Meanwhile, for permeability and hydrophilicity, the ideal loading is 0.5 g of ZIF-8 (M-0.5). This concentration yielded the optimal equilibrium of porosity (83.5%), the minimal water contact angle (49.4°), and the maximal pure water flux (197.1 L m⁻² h⁻¹). Nonetheless, the TDS rejection rate was rather low at 8.0–21.1%. The membrane effectively preserved effluent pH stability between 7.9 and 8.3. The aggregation of ZIF-8 at elevated concentrations diminished mechanical strength and selectivity. Additional optimization is required to equilibrate these performance indicators. Full article

Objectives: To address the critical limitations of current formulations that fail to simultaneously resolve indomethacin’s poor water solubility, susceptibility to gastric acid hydrolysis, and difficulty in balancing rapid onset with long-term sustained release, this study prepared solid dispersions via anti-solvent freeze-drying to improve drug dissolution, constructed oral buccoadhesive bilayer controlled-release tablets using direct powder compression, and elucidated the intrinsic relationships among polymer gel properties, swelling-erosion behavior, tablet integrity maintenance, and drug release mechanisms. Methods: Solid dispersions (SDs) were prepared by anti-solvent freeze-drying. Bilayer tablets (25 mg IND/tablet, 12.5 mg/layer) were fabricated via direct powder compression after optimizing disintegrants and polymer matrices. In vitro dissolution, surface pH, adhesion time, and adhesion strength were evaluated. Results: SDs enhanced dissolution by at least 30-fold in water and 2.4-fold at pH 6.8 within 2 h versus pure drug. Optimized bilayer tablets achieved 45% drug release at 20 min and 80% sustained release over 8 h, with surface pH of 6.8 ± 0.1, adhesion time of 8.3 ± 0.1 h, and adhesion strength of 57 ± 0.13 g. Conclusions: The physicochemical properties of polymeric excipients are critical for balancing drug release and mucoadhesion in buccal tablets. To achieve ideal controlled-release effects, in addition to focusing on the swelling and erosion characteristics of matrix-based tablets, the ability to maintain tablet integrity during dynamic dissolution must be further investigated, which is an essential factor for ensuring precisely modulated drug release. Meanwhile, when employing solid dispersions as solubilizing intermediates to prepare controlled-release formulations, the gelling properties of polymers in each formulation component should be fully considered to avoid incomplete disintegration and insufficient release at the initial dissolution stage. Full article

Volcanic super-eruptions can perturb atmospheric composition and climate-relevant radiative properties in ways that are not captured by simple scaling from Pinatubo-like events. This study presents a reduced-order regime theory for the coupled evolution of stratospheric sulfur, sulfate aerosol burden, reactive halogens, ozone loss, stratospheric thermal adjustment, and aerosol residence time. The analysis is intended as an interpretive tool for organizing sulfur-rich volcanic scenarios, comparing literature-based benchmark classes, and designing chemistry–climate model experiments, rather than as an event-specific calibration or a substitute for three-dimensional models. Four control parameters structure the response: sulfur loading relative to microphysical saturation, effective halogen strength, ash-uptake efficiency, and dynamical lifetime sensitivity, with hemispheric asymmetry treated diagnostically. An external consistency check against published Pinatubo-like, idealized 10–40 teragrams of sulfur (Tg S), Toba-like, and Los Chocoyos-like responses is used to evaluate whether the reduced theory reproduces the expected rank ordering of aerosol saturation, forcing-efficiency decline, ozone-loss amplification, ash-driven sulfur suppression, and residence-time sensitivity. This comparison does not assign pointwise error margins against three-dimensional model output; it evaluates regime membership, sign of response, rank ordering, and broad magnitude behavior. The main conclusion is that volcanic super-eruption impacts are governed by interacting regime transitions rather than by sulfur mass alone. Microphysical saturation can limit forcing efficiency, halogens can shift the system toward chemically amplified ozone depletion, ash uptake can reduce the effective sulfur burden during the early phase, and dynamical state can control persistence and hemispheric expression. By separating these mechanisms, the study provides a compact basis for interpreting large volcanic perturbations to atmospheric chemistry and for designing targeted model experiments on extreme eruption scenarios. Full article

Smart museums increasingly rely on digital media, interactive installations, artificial intelligence, augmented reality, and virtual reality to support cultural communication and visitor engagement. However, existing studies have mainly examined specific technologies, usability, or visitor satisfaction, while a systematic and quantitative framework for comparing interactive experience across different smart museums remains limited. To address this gap, this study proposes a hybrid multi-criteria decision-making framework for evaluating smart museum interactive experience. Based on the Strategic Experiential Modules, an evaluation system consisting of five dimensions—Sense, Feel, Think, Act, and Relate—and sixteen indicators was constructed. The Analytic Hierarchy Process was used to determine subjective weights from expert judgments, the entropy method was applied to capture the data-driven dispersion characteristics of expert evaluation data, and a game-theoretic combination weighting strategy was used to integrate the two weighting results. Subsequently, the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) was employed to compare five representative smart museum cases. The results show that Zhejiang Provincial Museum achieved the highest relative closeness value (C_i = 0.9891), followed by Shanghai Museum (C_i = 0.8457) and Hunan Museum (C_i = 0.5326). Robustness analysis further showed that the ranking order remained consistent under entropy weights, AHP weights, average weights, and game-theoretic combined weights. The Friedman test indicated no significant difference in the relative closeness coefficients across weighting schemes (χ² = 1.200, p = 0.753). These findings indicate that the proposed framework can effectively identify relative strengths and weaknesses in smart museum interactive experience and provide a replicable decision-support tool for experience-oriented museum design and optimization. Full article

Water is a key factor affecting the mechanical properties and stability of rock masses in underground engineering. In practical engineering settings, water distribution is commonly spatially heterogeneous, and the relative orientation between water distribution and the stress direction may further complicate the mechanical response and failure behavior of rocks. To investigate this issue under controlled laboratory conditions, Linyi red sandstone was selected, and four groups of specimens with distinct water-bearing states (oven-dried, fully saturated, axially semi-saturated, and radially semi-saturated) were prepared using tailored immersion protocols. Laboratory uniaxial compression tests and simplified discrete element simulations were combined to examine the macroscopic mechanical response, failure localization, and mesoscopic damage evolution of sandstone under directional heterogeneous water distribution. The results indicate that the water-bearing state strongly affects the uniaxial compressive strength and apparent deformation modulus of sandstone; compared with oven-dried specimens, fully saturated specimens show an approximately 40–60% reduction in these parameters, whereas semi-saturated specimens exhibit intermediate values. The relative orientation between the water distribution and loading direction further influences the failure pattern of semi-saturated specimens. Failure in semi-saturated specimens tends to initiate or localize in water-affected regions, while the multi-stage post-peak response of radially semi-saturated specimens can be interpreted as a sequential load-transfer process between saturated and dry regions. Heterogeneous water distribution also affects microcrack development and force-chain redistribution, with the idealized dry–wet transition region acting as a sensitive zone for crack initiation and stress redistribution. This study clarifies the first-order influence of directional heterogeneous water distribution on the mechanical behavior of sandstone and provides support for stability assessment and disaster mitigation in underground rock engineering under complex water-bearing conditions. Full article

This study evaluated the effectiveness of maleic anhydride polypropylene (MAPP) in improving the mechanical performance and interfacial adhesion of lignocellulosic fiber-reinforced polypropylene (PP) composites. Based on Scanning Electron Microscopy (SEM) investigations, the relationship between fiber fraction, MAPP content, mechanical characteristics, and fracture morphology was the main focus. The test results showed that the stiffness and tensile strength of the composites increased with the addition of MAPP. The esterification reaction between the anhydride groups of MAPP and the hydroxyl groups of the fibers strengthened the interphase covalent bond, with the 46:50:4 composition producing the highest elastic modulus of 79.67 MPa and maximum tensile stress of 11.01 MPa. The dense interphase zone, few gaps, and no dominant fiber tension were all confirmed by SEM morphology, and also indicated effective stress transfer from the PP matrix to the fibers. However, the toughness of the material decreased significantly with increasing stiffness. Due to strong plastic deformation in the PP matrix that is not tightly attached to the fibers, the composition without MAPP (30:70:0) shows high impact energy and breaking strain, reaching 25.39 kJ/m² and 121.26%, respectively. The increase in chemical bonding at 4% MAPP content limits the mobility of the polymer chains, making it more brittle. In addition, even though MAPP is still present in the system, increasing the fiber fraction above 60% causes agglomeration, decreased homogeneity, and increased voids due to limited matrix wetting, ultimately deteriorating the mechanical properties. Tensile stress and elastic modulus have a very strong positive correlation (R² = 0.93), while impact energy and strain have a good correlation (R² = 0.89). The results overall showed that the ideal MAPP dosage is in the range of 4% before interface saturation occurs and confirmed that MAPP efficiency is determined by the balance between fiber composition, MAPP quantity, and dispersion homogeneity. Full article