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28 pages, 15616 KiB  
Article
Binary Secretary Bird Optimization Algorithm for the Set Covering Problem
by Broderick Crawford, Felipe Cisternas-Caneo, Ricardo Soto, Claudio Patricio Toledo Mac-lean, José Lara Arce, Fabián Solís-Piñones, Gino Astorga and Giovanni Giachetti
Mathematics 2025, 13(15), 2482; https://doi.org/10.3390/math13152482 - 1 Aug 2025
Viewed by 202
Abstract
The Set Coverage Problem (SCP) is an important combinatorial optimization problem known to be NP-complete. The use of metaheuristics to solve the SCP includes different algorithms. In particular, binarization techniques have been explored to adapt metaheuristics designed for continuous optimization problems to the [...] Read more.
The Set Coverage Problem (SCP) is an important combinatorial optimization problem known to be NP-complete. The use of metaheuristics to solve the SCP includes different algorithms. In particular, binarization techniques have been explored to adapt metaheuristics designed for continuous optimization problems to the binary domain of the SCP. In this work, we present a new approach to solve the SCP based on the Secretary Bird Optimization Algorithm (SBOA). This algorithm is inspired by the natural behavior of the secretary bird, known for its ability to hunt prey and evade predators in its environment. Since the SBOA was originally designed for optimization problems in continuous space and the SCP is a binary problem, this paper proposes the implementation of several binarization techniques to adapt the algorithm to the discrete domain. These techniques include eight transfer functions and five different discretization methods. Taken together, these combinations create multiple SBOA adaptations that effectively balance exploration and exploitation, promoting an adequate distribution in the search space. Experimental results applied to the SCP together with its variant Unicost SCP and compared to Grey Wolf Optimizer and Particle Swarm Optimization suggest that the binary version of SBOA is a robust algorithm capable of producing high quality solutions with low computational cost. Given the promising results obtained, it is proposed as future work to focus on complex and large-scale problems as well as to optimize their performance in terms of time and accuracy. Full article
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20 pages, 10170 KiB  
Article
Birds and People in Medieval Bulgaria—A Review of the Subfossil Record of Birds During the First and Second Bulgarian Empires
by Zlatozar Boev
Quaternary 2025, 8(3), 36; https://doi.org/10.3390/quat8030036 - 8 Jul 2025
Viewed by 511
Abstract
For the first time, the numerous scattered data on birds (wild and domestic) have been collected based on their medieval bone remains discovered on the modern territory of the Republic of Bulgaria. The collected information is about a total of 37 medieval settlements [...] Read more.
For the first time, the numerous scattered data on birds (wild and domestic) have been collected based on their medieval bone remains discovered on the modern territory of the Republic of Bulgaria. The collected information is about a total of 37 medieval settlements from the time of the First and Second Bulgarian Empires. Among the settlements studied are both the two medieval Bulgarian capitals (Pliska and Veliki Preslav), as well as other cities, smaller settlements, military fortresses, monasteries, and inhabited caves. The data refer to a total of 48 species of wild birds and 6 forms of domestic birds of 11 avian orders: Accipitriformes, Anseriformes, Ciconiiformes, Columbiformes, Falconiformes, Galliformes, Gruiformes, Otidiformes, Passeriformes, Pelecaniformes, and Strigiformes. The established composition of wild birds amounts to over one tenth (to 11.5%) of the modern avifauna in the country. Five of the established species (10.4%) have disappeared from the modern nesting avifauna of the country—the bearded vulture, the great bustard, the little bustard, the gray crane, and the saker falcon (the latter two species have reappeared as nesters in the past few years). First Bulgarian Empire (681–1018): Investigated settlements—22. Period covered—five centuries (7th to 11th c.). Found in total: at least 44 species/forms of birds, of which 39 species of wild birds and 5 forms of poultry. Second Bulgarian Empire (1185–1396): Investigated settlements—15. Period covered—3 centuries (12th to 14th c.). Found in total: at least 39 species/forms of birds, of which 33 species of wild birds and 6 forms of poultry. The groups of raptors, water, woodland, openland, synanthropic and domestic birds were analyzed separately. The conclusion was made that during the two periods of the Middle Ages, birds had an important role in the material and spiritual life of the population of the Bulgarian lands. Birds were mainly used for food (domestic birds), although some were objects of hunting. No traces of processing were found on the bones. Birds were subjects of works of applied and monumental art. Their images decorated jewelry, tableware, walls of buildings and other structures. Full article
(This article belongs to the Special Issue Quaternary Birds of the Planet of First, Ancient and Modern Humans)
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17 pages, 1104 KiB  
Article
Dynamics of Sex and Age Correlation of Eurasian Woodcock (Scolopax rusticola L.) During Spring Migration in Hungary
by Attila Bende, Sándor Faragó, Richárd László, Viktória Csanády, István Fekete, Tibor Pecsics and László Bozó
Birds 2025, 6(2), 30; https://doi.org/10.3390/birds6020030 - 16 Jun 2025
Viewed by 648
Abstract
Based on samples collected in the framework of the Eurasian Woodcock Bagging Program in Hungary between 2010 and 2019, we investigated the spring migration of Eurasian Woodcock by age class and sex. The dynamical properties of each year’s trajectory are represented using Gaussian [...] Read more.
Based on samples collected in the framework of the Eurasian Woodcock Bagging Program in Hungary between 2010 and 2019, we investigated the spring migration of Eurasian Woodcock by age class and sex. The dynamical properties of each year’s trajectory are represented using Gaussian smoothing. The models were used to determine the peak of the migration by sex and age in each year. In the comparative analysis by sex, an ARIMA regression model was used as a time-series analysis, which showed that there was a strong positive correlation between the migration of females and males in each year, which indicates that there is no statistically verifiable time difference in the migration pattern of each sex. We found a positive correlation in the same ARIMA model for each year of migration, which indicates that there is no statistically verifiable difference in the spring migration of males and females of the same age groups in Hungary. This study also demonstrates that there is a sharp ratio shift in the spring migration in favour of males. This significant imbalance can be explained by the selective hunting during spring roding, which is of particular importance for the sustainable utilisation of the species. Full article
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19 pages, 964 KiB  
Article
SGMNet: A Supervised Seeded Graph-Matching Method for Cyber Threat Hunting
by Chenghong Zhang and Lingyin Su
Symmetry 2025, 17(6), 898; https://doi.org/10.3390/sym17060898 - 6 Jun 2025
Viewed by 438
Abstract
Proactively hunting known attack behaviors within system logs, termed threat hunting, is gaining traction in cybersecurity. Existing methods typically rely on constructing a query graph representing known attack patterns and identifying it as a subgraph within a system-wide provenance graph. However, the large [...] Read more.
Proactively hunting known attack behaviors within system logs, termed threat hunting, is gaining traction in cybersecurity. Existing methods typically rely on constructing a query graph representing known attack patterns and identifying it as a subgraph within a system-wide provenance graph. However, the large scale and redundancy of provenance data lead to poor matching efficiency and high false-positive rates. To address these issues, this paper introduces SGMNet, a supervised seeded graph-matching network designed for efficient and accurate threat hunting. By selecting indicators of compromise (IOCs) as initial seed nodes, SGMNet extracts compact subgraphs from large-scale provenance graphs, significantly reducing graph size and complexity. It then learns adaptive node-expansion strategies to capture relevant context while suppressing irrelevant noise. Experiments on four real-world system log datasets demonstrate that SGMNet achieves a runtime reduction of over 60% compared to baseline methods, while reducing false positives by 35.2% on average. These results validate that SGMNet not only improves computational efficiency but also enhances detection precision, making it well suited for real-time threat hunting in large-scale environments. Full article
(This article belongs to the Section Computer)
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12 pages, 940 KiB  
Article
Cell Viability of Skin Tissue Collected from Postmortem Neotropical Deer: A Novel Perspective for Conservation Biotechnology
by Luciana Diniz Rola, Iara Maluf Tomazella, Eluzai Dinai Pinto Sandoval, Jorge Alfonso Morales-Donoso, Carolina Heloisa de Souza Borges and José Maurício Barbanti Duarte
J. Zool. Bot. Gard. 2025, 6(2), 31; https://doi.org/10.3390/jzbg6020031 - 6 Jun 2025
Viewed by 1230
Abstract
Considering the taxonomic uncertainties of Neotropical deer species, as well as the threat status of many of them, new studies and strategies for their maintenance are urgently needed. Obtaining live cells is of great importance for the conservation of wild species in order [...] Read more.
Considering the taxonomic uncertainties of Neotropical deer species, as well as the threat status of many of them, new studies and strategies for their maintenance are urgently needed. Obtaining live cells is of great importance for the conservation of wild species in order to allow cytogenetic and molecular studies to be carried out and for the construction of genomic resource banks. In order to increase the genetic diversity stored in these banks, the possibility of collecting skin fragments from dead animals (e.g., run over, hunted, deaths related to disease or natural causes) becomes a valuable source and a last alternative for obtaining material from these individuals. However, the interval between the death of the animal and the collection of tissue can directly interfere with the quality of the sample obtained and it is therefore essential to identify the maximum time during which viable cells are still found. Thus, this study sought to establish a protocol for the collection, storage, cryopreservation, and cultivation of skin obtained postmortem from individuals of the species Subulo gouazoubira (gray brocket deer) and Mazama rufa (red brocket deer). The collection of tissue fragments at different postmortem intervals (0 h, 1 h, 2 h, 3 h, 4 h, 5 h, 6 h, 7 h, 8 h, 9 h, 10 h, and 11 h) was evaluated. The tissues were analyzed for fibroblast cell viability immediately after collection. Their ability to undergo cryopreservation was evaluated based on techniques that can be directly applied to samples obtained in the field and their subsequent thawing and success of cell cultures was performed in the laboratory. Regarding the genetic integrity of the cells, the number of metaphases was observed by the mitotic index. The cell viability presented by the samples always remained above 60%. It was possible to establish cell cultures even with the tissues obtained 11 h after the death of the individuals; however, they required twice as many days to reach bottle confluence compared to the cultures performed with the tissues obtained 0 h after the death of the individuals. The results suggest that the best rates of cell viability, time to reach confluence, and number of metaphases per cell (mitotic index) are found in skin fragments collected up to 5 h after the death of individuals when their carcasses are kept at room temperature. Full article
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22 pages, 2720 KiB  
Article
Research on the Diffusion of Green Energy Technological Innovation from the Perspective of International Cooperation
by Yan Li, Jun Wu and Xin-Ping Wang
Energies 2025, 18(11), 2816; https://doi.org/10.3390/en18112816 - 28 May 2025
Viewed by 440
Abstract
The diffusion of green energy technological innovation based on international green energy cooperation is a critical pathway to achieving global low-carbon emission reductions. However, few studies have considered the innovation diffusion pathways of green energy technologies under bilateral policy uncertainties. This paper constructs [...] Read more.
The diffusion of green energy technological innovation based on international green energy cooperation is a critical pathway to achieving global low-carbon emission reductions. However, few studies have considered the innovation diffusion pathways of green energy technologies under bilateral policy uncertainties. This paper constructs an evolutionary game model for the diffusion of green energy technological innovation in a complex network environment, with a focus on analyzing the impacts of key parameters such as policy spillover effects, technological heterogeneity, technical leakage risks, and free-riding risks on the equilibrium outcomes of evolutionary strategies. The results of the study are as follows: (1) Technological synergy and technological heterogeneity have a significant role in promoting the diffusion of green energy technological innovation, but when technological heterogeneity is too high, it is difficult for the two parties to find more common interests and areas of technological interaction, and the cooperative innovation will be turned into an empty shell that has a name but no reality. (2) Policy uncertainty has a significant impact on the diffusion of green energy technology innovation, and the specific impact depends on the type of policy, policy intensity, policy spillover effects, and other key parameters. (3) The risk of technological obsolescence has prompted countries to deeply participate in green energy international cooperation to realize the “curved road overtaking” of green energy technology based on technological locking and latecomer advantages; due to the existence of the phenomenon of “free-riding”, the logic of value creation based on win–win cooperation is replaced by the opportunism of “enjoying the benefits”, and cooperative innovation may be turned into a one-time “handshake agreement”. The existence of the risk of technology leakage can turn collaborative innovation into a “witch hunt” by the underdog against the overdog, and the diffusion process of green energy technology innovation is led in the wrong direction. Full article
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17 pages, 254 KiB  
Review
The Motivations of Recreational Hunters Who Violate Wildlife and Game Hunting Regulations: Implications for Crime Prevention
by Andrew Day, Stuart Ross, Jason Flesch and Simon J. Toop
Soc. Sci. 2025, 14(6), 343; https://doi.org/10.3390/socsci14060343 - 28 May 2025
Viewed by 638
Abstract
Recreational hunting is a highly regulated activity, in part because it can give rise to a variety of deleterious social, environmental, and economic harms. It provides an interesting area for those interested in community safety because of the way in which both formal [...] Read more.
Recreational hunting is a highly regulated activity, in part because it can give rise to a variety of deleterious social, environmental, and economic harms. It provides an interesting area for those interested in community safety because of the way in which both formal (e.g., enforcement officers, proscribed areas and times for hunting, licensing, etc.) and informal (e.g., community awareness and education, conservation) methods of crime prevention are applied. And yet, the criminological literature on effective regulation is not only limited but diverse in terms of scope, types of behavior considered (e.g., poaching, wildlife trading, recreation, etc.), and the context that is considered (e.g., geographical, cultural, etc.). In this paper, we present how a crime prevention and compliance response can be used to understand the nature of the issue and the individual and socio-political processes that result in non-compliance with hunting regulations. We present an overview of the status of recreational hunting in an Australian jurisdiction and locate the regulatory issues that arise within the research literature that explores the various motivations that are known to drive illegal hunting. These are then considered in relation to how community-oriented and non-coercive measures might be employed to improve prevent criminal behavior at the primary, secondary, and tertiary levels. Full article
11 pages, 1288 KiB  
Article
Development of the Roe Deer–Fascioloides magna Association over Time
by Anja France Noëlle Renée Buet, Miljenko Bujanić, Krešimir Krapinec, Ivica Bošković, Anđelko Gašpar and Dean Konjević
Pathogens 2025, 14(6), 516; https://doi.org/10.3390/pathogens14060516 - 22 May 2025
Viewed by 501
Abstract
The trematode Fascioloides magna is originally a parasite of North American deer species. Upon its arrival to Europe, F. magna met new intermediate and final hosts. Depending on the type of host, the clinical picture, pathological findings, epidemiology and outcome can vary significantly. [...] Read more.
The trematode Fascioloides magna is originally a parasite of North American deer species. Upon its arrival to Europe, F. magna met new intermediate and final hosts. Depending on the type of host, the clinical picture, pathological findings, epidemiology and outcome can vary significantly. As an aberrant host, it was long believed that the roe deer (Capreolus capreolus) fails to develop pseudocysts, and therefore the infected animal dies before the parasite can mature and start to produce eggs. In this study, 676 roe deer livers were collected in Croatia during the hunting years of four consecutive years (2019–2023) in Bjelovar-Bilogora County (BB), and 184 livers were collected from Zagreb County (ZG) in the hunting year 2022/2023. Livers were analysed macroscopically and on a cut surface for lesions and any developmental stage of F. magna according to a standard protocol. The mean prevalence of infected livers during the whole study period was 12.86% in BB and 3.8% in ZG. No pseudocysts were detected in samples from ZG, while there was an increasing trend of pseudocyst presence over time in BB. The occurrence of pseudocysts in infected livers showed a rapid increase after the hunting season 2019/2020, before becoming constant (at approx. 40%). The odds of finding pseudocysts ranged between 2.7 (OR = 2.7317, CI 95% 0.3108 to 24.0095, p = 0.365) and 2.9 (OR = 2.9167, CI 95% 0.3163 to 26.8924, p = 0.345) times higher in later years compared to 2019/2020. Similarly, an increasing trend (though less pronounced) was observed in the numbers of livers simultaneously containing pseudocysts and fluke migratory stages. The results indicate a potential change in the roe deer–F. magna association, where an increasing number of roe deer are forming pseudocysts and can survive even multiple infections. Full article
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18 pages, 6383 KiB  
Study Protocol
The Impact of Hollow Wear on the Stability of High-Speed Railway Vehicles
by Ling Zhang, Junping Hu, Chen Wang and Zechao Liu
Appl. Sci. 2025, 15(7), 4060; https://doi.org/10.3390/app15074060 - 7 Apr 2025
Viewed by 505
Abstract
Hollow wear on wheels is a common form of surface damage often observed in high-velocity vehicles. It is widely recognized that hollow wear of the wheel tread degrades the dynamic performance of rail vehicles, especially in the issue commonly referred to as “operational [...] Read more.
Hollow wear on wheels is a common form of surface damage often observed in high-velocity vehicles. It is widely recognized that hollow wear of the wheel tread degrades the dynamic performance of rail vehicles, especially in the issue commonly referred to as “operational stability”, and leads to abnormal wheel–rail contact interactions. However, the evaluation criteria for vehicle stability are not uniform, which affects the assessment of wheel conditions and the timing of wheel re-profiling during maintenance. Therefore, numerical simulations were conducted by matching the measured worn wheel profiles with standard rails, and three different methods were employed to evaluate vehicle stability in this article. The numerical results revealed that the wheel equivalent conicity exhibits a nonlinear characteristic caused by hollow wear, which means that the nominal equivalent conicity is unable to accurately represent the geometric contact relationship between the wheel and rail. Under identical wheel wear conditions, a certain difference was observed in the critical speed of the vehicle determined by the velocity-reducing method and the bifurcation configuration method. Both methods were capable of reflecting the impact of wheel hollow wear on vehicle stability at the critical speed. Compared to the velocity-reducing method, the bifurcation configuration method can better reflect the transition process of a vehicle from stable running to hunting instability. Furthermore, the lateral vibration acceleration values measured above the bogie frame indicated that slight wheel wear is insensitive to increased speed. However, when the wear was severe, the lateral vibration acceleration of the bogie was found to increase sharply, exceeding the established stability criteria. This phenomenon was consistent with the safety alarms that occurred during actual vehicle operation, indicating that the vehicle had failed to meet stability requirements. Full article
(This article belongs to the Special Issue New Insights into Railway Vehicle Dynamics)
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20 pages, 808 KiB  
Article
Optimized Integral Super-Twisting Sliding Mode Control for Acute Leukemia Therapy
by Muhammad Munir Butt and Azhar Iqbal Kashif Butt
Mathematics 2025, 13(7), 1077; https://doi.org/10.3390/math13071077 - 25 Mar 2025
Viewed by 455
Abstract
This paper presents an optimized nonlinear controller, the Integral Super-Twisting Sliding Mode Control (ISTSMC), for acute leukemia therapy. To enhance its performance, we introduce the RedFox Optimization Algorithm, a nature-inspired technique based on the hunting behavior of red foxes. This algorithm is utilized [...] Read more.
This paper presents an optimized nonlinear controller, the Integral Super-Twisting Sliding Mode Control (ISTSMC), for acute leukemia therapy. To enhance its performance, we introduce the RedFox Optimization Algorithm, a nature-inspired technique based on the hunting behavior of red foxes. This algorithm is utilized to fine-tune the controller parameters, ensuring optimal achievement of control objectives. We discuss the fundamentals of ISTSMC, Sliding Mode Control, and Synergetic Control, detailing their optimization methodology using the RedFox Algorithm. The effectiveness of ISTSMC is evaluated through numerical simulations and compared with traditional Sliding Mode Control (SMC) and Synergetic Control (SC). The results demonstrate that ISTSMC achieves superior performance with a steady state error of 53.85, a settling time of 59.60, and a transient time of 4.7942, significantly outperforming SMC and SC. Additionally, ISTSMC reduces leukemic cell levels to a safe threshold more efficiently while maintaining healthy cell populations within acceptable limits. These improvements highlight the potential of ISTSMC in optimizing chemotherapy administration, ensuring better patient outcomes while minimizing side effects. Full article
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28 pages, 8756 KiB  
Article
Stable Isotope Analysis of Pleistocene Proboscideans from Afar (Ethiopia) and the Dietary and Ecological Contexts of Palaeoloxodon
by Julie Luyt, Yonatan Sahle and Deano Stynder
Quaternary 2025, 8(1), 16; https://doi.org/10.3390/quat8010016 - 20 Mar 2025
Viewed by 1891
Abstract
The timing, cause, and magnitude of mammalian extinctions during the African Middle Pleistocene remain largely unresolved. The demise of Elephas/Palaeoloxodon recki, a lineage that had a great geographic and temporal span, represents a particularly enigmatic case of megafaunal extinction. Previous studies of Early [...] Read more.
The timing, cause, and magnitude of mammalian extinctions during the African Middle Pleistocene remain largely unresolved. The demise of Elephas/Palaeoloxodon recki, a lineage that had a great geographic and temporal span, represents a particularly enigmatic case of megafaunal extinction. Previous studies of Early Pleistocene fossil material have proposed that this lineage was a strict C4-grazer, with its dietary specialization causing its extinction during a period of climatic instability that coincided with the Late Acheulean. Others have associated its disappearance with overhunting by hominins during the same period. We contribute to this debate by analyzing carbon and oxygen isotope data from the tooth enamel of late Early and Middle Pleistocene Palaeoloxodon specimens from various localities in the Afar Rift. To contextualize the isotopic data of Palaeoloxodon within its broader ecosystem, we also provide data from non-elephant species. Carbon isotope values indicate that while C4 plants dominated diets, varying amounts of C3 vegetation were also consumed throughout this period. Oxygen isotope values reflect an initial focus on stable water sources that were later broadened to include transient sources. Serially sampled teeth of P. cf. recki recki from Late Acheulean contexts in the Megenta research area show no significant seasonal shifts in δ13C or δ18O values, even during a period of heightened climatic instability regionally. Taken together, our results suggest that Palaeoloxodon was capable of flexibility in diet and drinking habits which belies its morphological specializations. Our results do not support the idea that an inability to adapt to climatic instability caused the extinction of P. recki recki during the Late Acheulean. There is also currently no solid evidence that hominin hunting activities were the cause. However, we cannot discount the potential cumulative impact of climatic-induced environmental pressures and advancements in hominin hunting technologies during the early Middle Stone Age on the eventual extinction of the Palaeoloxodon lineage during the Middle–Late Pleistocene interface. Full article
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12 pages, 2316 KiB  
Article
Game Species Management and Ecosystem Health: Leveraging Vulture Scavenging to Improve Carcass Disposal and Health Risk Reduction
by Inmaculada Navarro and Raquel Castillo-Contreras
Animals 2025, 15(5), 732; https://doi.org/10.3390/ani15050732 - 4 Mar 2025
Viewed by 1039
Abstract
Avian scavengers, particularly vultures, play a crucial role in ecosystem health by efficiently consuming carcasses, thereby reducing pathogen abundance and limiting disease transmission to wildlife, livestock, and humans. In addition to the indispensable role of vultures, they are a particularly threatened group of [...] Read more.
Avian scavengers, particularly vultures, play a crucial role in ecosystem health by efficiently consuming carcasses, thereby reducing pathogen abundance and limiting disease transmission to wildlife, livestock, and humans. In addition to the indispensable role of vultures, they are a particularly threatened group of birds. This study investigates the environmental factors that optimize this ecosystem service by examining the scavenging dynamics of vultures and other species at deer carcasses in a hunting area in Sierra Madrona, Ciudad Real, Spain. Carcasses were placed in habitats with different vegetation densities (open vs. dense) and altitudes (high vs. low) and were monitored for 30 days using camera traps. Data on scavenger diversity, arrival times, and carcass persistence were analyzed using Bayesian multilevel models. Results reveal that vegetation density and altitude significantly influence vulture arrival times and carcass duration, with dense vegetation and low altitudes delaying scavenger access. These findings provide actionable insights for game management to enhance vulture conservation and improve both public and ecosystem health through timely and effective carcass removal. Full article
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14 pages, 2297 KiB  
Article
Plasma miR-145-5p Levels and Risk of Future Cancer—Results from the HUNT Study
by Christopher Antoun, Julia Oto, Vânia M. Morelli, Kristian Hveem, Sigrid K. Brækkan, Pilar Medina and John-Bjarne Hansen
Int. J. Mol. Sci. 2025, 26(5), 2191; https://doi.org/10.3390/ijms26052191 - 28 Feb 2025
Viewed by 865
Abstract
MicroRNA-145-5p (miR-145) has been reported to regulate multiple oncogenes and is considered a tumor suppressor. However, it remains unknown whether the level of plasma miR-145 can serve as a risk biomarker for future cancer. Using a population-based cohort (n = 1740) derived [...] Read more.
MicroRNA-145-5p (miR-145) has been reported to regulate multiple oncogenes and is considered a tumor suppressor. However, it remains unknown whether the level of plasma miR-145 can serve as a risk biomarker for future cancer. Using a population-based cohort (n = 1740) derived from the Trøndelag Health Study (HUNT), we investigated whether plasma miR-145 levels were associated with (1) first life-time cancer, (2) cancer stage at diagnosis, and (3) 2-year all-cause mortality after cancer diagnosis. Cox regression analysis was used to estimate hazard ratios (HR) and 95% confidence intervals (CI). Our findings showed that individuals in the highest quartile of plasma miR-145 levels had a 44% increased risk of developing cancer compared to those in the lowest quartile, independent of age, sex, body mass index, or smoking status (HR 1.44, 95% CI 1.03–2.00 p < 0.05). However, no association was observed between quartiles of miR-145 levels and the risk of being diagnosed with a metastatic cancer, or the risk of 2-year mortality after cancer diagnosis. Our findings suggest that high plasma miR-145 levels are associated with increased cancer risk without affecting the severity of the cancer at diagnosis or affecting the short-term prognosis. Full article
(This article belongs to the Special Issue Molecular Research on Tumor Suppressor Proteins)
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15 pages, 1408 KiB  
Article
Predatory Behavior of Coccinella septempunctata on Two Different Aphid Species via Functional Response at Two Different Temperatures
by Muhammad Usama Altaf, Adeel Mukhtar, Muazzama Batool, Syed Muhammad Zaka, Rashid Azad, Yasir Hameed, Alia Tajdar, Asad Ali and Waqar Jaleel
Biology 2025, 14(3), 245; https://doi.org/10.3390/biology14030245 - 28 Feb 2025
Viewed by 1081
Abstract
Coccinella septempunctata (Linnaeus, 1758) is a voracious predator all over the world where aphids have found a niche. Behavioral studies of C. septempunctata are very important to make them effective bio-controllers. Therefore, this study explains the functional response of C. septempunctata praying on [...] Read more.
Coccinella septempunctata (Linnaeus, 1758) is a voracious predator all over the world where aphids have found a niche. Behavioral studies of C. septempunctata are very important to make them effective bio-controllers. Therefore, this study explains the functional response of C. septempunctata praying on two distinct aphid species, examined in this work at two different temperatures. Six different prey densities (4, 8, 16, 32, 64, and 128 aphids) and two different temperatures (15 and 25 °C) were used in the experiment. All of the development stages of the predator were used to perform the experiment. Every experiment was replicated five times. The type and parameters of functional response were ascertained by the application of Roger’s random predator models and logistic regression. Results showed that C. septempunctata adults and larvae both had a type II functional reaction against the tested aphids in both temperatures. When comparing the fourth instar to other predatory stages, the attack rate against both aphids was shown to be greater. As the temperature rose, so did the attack rate. Fourth instar larvae exhibited attack rates of 1.314 h−1 on Aphis nerii Fonscolombe, 1758 (Hemiptera: Aphididae) and 1.959 h−1 on Lipaphis erysimi Kaltenbach, 1843 (Hemiptera: Aphididae) at 15 °C, while at 25 °C, the rates were 1.747 h−1 and 1.321 h−1, respectively. Handling time was influenced by both temperature and predator stage. As the temperature increased, the handling time of the later predatory stages decreased. This study suggests that later predatory stages of C. septempunctatas actively hunt aphids at higher temperatures. Full article
(This article belongs to the Topic Environmental Bioengineering and Geomicrobiology)
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24 pages, 6647 KiB  
Article
Knowledge-Guided Reinforcement Learning with Artificial Potential Field-Based Demonstrations for Multi-Autonomous Underwater Vehicle Cooperative Hunting
by Yang Wang, Weiye Wang and Deshan Chen
J. Mar. Sci. Eng. 2025, 13(3), 423; https://doi.org/10.3390/jmse13030423 - 24 Feb 2025
Cited by 1 | Viewed by 980
Abstract
Multi-AUV cooperative hunting requires autonomous underwater vehicles (AUVs) to strategize the encirclement of evaders while navigating around obstacles and other AUVs. Despite the promise of multi-agent reinforcement learning (MARL) in continuous control problems, its low sample efficiency poses a challenge in unknown environments [...] Read more.
Multi-AUV cooperative hunting requires autonomous underwater vehicles (AUVs) to strategize the encirclement of evaders while navigating around obstacles and other AUVs. Despite the promise of multi-agent reinforcement learning (MARL) in continuous control problems, its low sample efficiency poses a challenge in unknown environments and complex control scenarios. To overcome these limitations, we present a Knowledge-Guided Reinforcement Learning (KG-RL) approach, which integrates an Artificial Potential Field (APF) to enhance sample efficiency and operational safety. Our methodology is bifurcated into pre-training and fine-tuning phases. During the pre-training phase, an APF is employed to generate a concise set of demonstration trajectories that provide agents with foundational knowledge. Subsequently, the fine-tuning phase leverages real-time APF knowledge to direct the learning process, encouraging agents to balance following demonstrated actions with seeking out more optimal solutions. We assess the efficacy of our method through extensive simulations across diverse tasks, demonstrating its ability to expedite the learning process and yield more strategic decision-making. Our approach achieves superior results compared to traditional MARL benchmarks, particularly in learning efficiency, decision quality, and overall performance. Full article
(This article belongs to the Section Ocean Engineering)
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