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150 Results Found

  • Protocol
  • Open Access
1 Citations
6,707 Views
8 Pages

Optimization of Nile Tilapia Artificial Breeding Using Human Chorionic Gonadotropin (hCG) Hormone

  • Golam Rbbani,
  • Prabhugouda Siriyappagouder,
  • Riaz Murshed,
  • Rajesh Joshi,
  • Artem Nedoluzhko,
  • Jorge Galindo-Villegas and
  • Jorge M. O. Fernandes

Nile tilapia (Oreochromis niloticus) is the most widely farmed tilapia species globally, making it one of the most important aquaculture species. To meet increasing demand, hatcheries occasionally use artificial breeding techniques such as hormonal i...

  • Article
  • Open Access
15 Citations
4,889 Views
14 Pages

Identification of Key Receptor Residues Discriminating Human Chorionic Gonadotropin (hCG)- and Luteinizing Hormone (LH)-Specific Signaling

  • Clara Lazzaretti,
  • Valentina Secco,
  • Elia Paradiso,
  • Samantha Sperduti,
  • Claudia Rutz,
  • Annika Kreuchwig,
  • Gerd Krause,
  • Manuela Simoni and
  • Livio Casarini

25 December 2020

(1) The human luteinizing hormone (LH)/chorionic gonadotropin (hCG) receptor (LHCGR) discriminates its two hormone ligands and differs from the murine receptor (Lhr) in amino acid residues potentially involved in qualitative discerning of LH and hCG....

  • Review
  • Open Access
133 Citations
41,126 Views
15 Pages

hCG: Biological Functions and Clinical Applications

  • Chinedu Nwabuobi,
  • Sefa Arlier,
  • Frederick Schatz,
  • Ozlem Guzeloglu-Kayisli,
  • Charles Joseph Lockwood and
  • Umit Ali Kayisli

22 September 2017

Human chorionic gonadotropin (hCG) is produced primarily by differentiated syncytiotrophoblasts, and represents a key embryonic signal that is essential for the maintenance of pregnancy. hCG can activate various signaling cascades including mothers a...

  • Communication
  • Open Access
9 Citations
3,978 Views
11 Pages

29 January 2021

Human chorionic gonadotropin (hCG) is a hormone that specifically binds to luteinizing hormone receptor (LHR) and exerts several roles, including the support of pregnancy and fetal gonadal steroidogenesis. Since hCG is also expressed by some tumor ty...

  • Article
  • Open Access
5 Citations
3,529 Views
10 Pages

Effect of Interval between Human Chorionic Gonadotropin Priming and Ovum Pick-up on the Euploid Probabilities of Blastocyst

  • Chun-I Lee,
  • Hsiu-Hui Chen,
  • Chun-Chia Huang,
  • Chien-Hong Chen,
  • En-Hui Cheng,
  • Jing Yang Huang,
  • Maw-Sheng Lee and
  • Tsung-Hsien Lee

This retrospective study attempts to elucidate the relevance of the interval between human chorionic gonadotropin priming and oocyte pick-up (hCG-OPU) to the euploidy probability of biopsied blastocysts in preimplantation genetic tests for aneuploidy...

  • Review
  • Open Access
68 Citations
10,348 Views
8 Pages

The Role of HCG in Implantation: A Mini-Review of Molecular and Clinical Evidence

  • Antonis Makrigiannakis,
  • Thomas Vrekoussis,
  • Emmanouel Zoumakis,
  • Sophia N. Kalantaridou and
  • Udo Jeschke

Embryo implantation is a complex process involving continuous molecular cross-talk between the embryo and the decidua. One of the key molecules during this process is human chorionic gonadotropin (HCG). HCG effectively modulates several metabolic pat...

  • Article
  • Open Access
3 Citations
4,652 Views
11 Pages

9 May 2022

Among the physiological changes occurring during pregnancy, the benefits of morning sickness, which is likely mediated by human chorionic gonadotropin (HCG) and induces serum ketone production, are unclear. We investigated the relationship between se...

  • Article
  • Open Access
2 Citations
5,014 Views
17 Pages

Competence of Combined Low Dose of Human Chorionic Gonadotropin (HCG) and Clomiphene Citrate (CC) Versus Continued CC during Ovulation Induction in Women with CC-Resistant Polycystic Ovarian Syndrome: A Randomized Controlled Trial

  • Mahmoud Thabet,
  • Mohamed Sayed Abdelhafez,
  • Maged Ragheb Elshamy,
  • Ibrahim A. Albahlol,
  • Emad Fayala,
  • Alaa Wageeh,
  • Ahmed Abdelhamid El-Zayadi,
  • Nagwan Ahmed Bahgat,
  • Shereen M. Mohammed and
  • Mahmoud Mohamed Abdel-razik
  • + 10 authors

12 August 2024

Background and Objectives: Polycystic ovarian syndrome (PCOS) is a widespread endocrine disorder affecting 5–18% of females in their childbearing age. The aim of this study is to assess the efficacy of combining a low dosage of human chorionic...

  • Article
  • Open Access
6 Citations
14,836 Views
12 Pages

Conservative Management for Retained Products of Conception in Late Pregnancy

  • Risa Fujishima,
  • Kaoru Kawasaki,
  • Kaori Moriuchi,
  • Reona Shiro,
  • Yoshie Yo and
  • Noriomi Matsumura

This retrospective study aims to compare the early manual removal of placenta (MROP) and conservative management of retained products of conception (RPOC) after 34 weeks of gestation. Nineteen cases underwent MROP within 24 h of delivery, of which ni...

  • Article
  • Open Access
1 Citations
3,679 Views
14 Pages

A Subovulatory Dose of Human Chorionic Gonadotropin (hCG) May Sustain Terminal Follicle Development and Reproductive Efficiency during Anestrus in Sheep

  • José Francisco Cox,
  • Albert Carrasco,
  • Felipe Navarrete,
  • Antonio Bocic,
  • Fernando Saravia and
  • Jesús Dorado

4 April 2024

The study tested the hypothesis that a single administration of hCG supports the LH-dependent phase of terminal follicular development in synchronized sheep during anestrus, using eCG as a functional reference. Using a clinical approach, four experim...

  • Review
  • Open Access
18 Citations
7,786 Views
6 Pages

hCG Triggering in ART: An Evolutionary Concept

  • Anat Hershko Klement and
  • Adrian Shulman

Human chorionic gonadotropin (hCG) is no longer a single, omnipotent ovulation triggering option. Gonadotropin releasing hormone (GnRH) agonist, initially presented as a substitute for hCG, has led to a new era of administering GnRH agonist followed...

  • Review
  • Open Access
43 Citations
19,927 Views
16 Pages

Human Chorionic Gonadotropin and Early Embryogenesis: Review

  • Sophie Perrier d’Hauterive,
  • Romann Close,
  • Virginie Gridelet,
  • Marie Mawet,
  • Michelle Nisolle and
  • Vincent Geenen

26 January 2022

Human chorionic gonadotropin (hCG) has four major isoforms: classical hCG, hyperglycosylated hCG, free β subunit, and sulphated hCG. Classical hCG is the first molecule synthesized by the embryo. Its RNA is transcribed as early as the eight-cell...

  • Review
  • Open Access
46 Citations
14,494 Views
8 Pages

Human Chorionic Gonadotropin: The Pregnancy Hormone and More

  • Charalampos Theofanakis,
  • Petros Drakakis,
  • Alexandros Besharat and
  • Dimitrios Loutradis

To thoroughly review the uses of human chorionic gonadotropin (hCG) related to the process of reproduction and also assess new, non-traditional theories. Review of the international literature and research studies. hCG and its receptor, LH/CGR, are e...

  • Review
  • Open Access
53 Citations
16,379 Views
9 Pages

17 October 2017

The pregnancy hormone, human chorionic gonadotropin (hCG), is crucially involved in processes such as implantation and placentation, two milestones of pregnancy whose successful progress is a prerequisite for adequate fetal growth. Moreover, hCG dete...

  • Article
  • Open Access
151 Views
12 Pages

15 January 2026

Effective luteal support is crucial for successful pregnancy following embryo transfer in dromedary camels, highlighting the importance of maintaining adequate luteal function. This study compared three luteal support protocols for pregnancy rates af...

  • Review
  • Open Access
25 Citations
8,585 Views
20 Pages

Human Chorionic Gonadotrophin as a Possible Mediator of Leiomyoma Growth during Pregnancy: Molecular Mechanisms

  • Veronica Sarais,
  • Greta Chiara Cermisoni,
  • Matteo Schimberni,
  • Alessandra Alteri,
  • Enrico Papaleo,
  • Edgardo Somigliana and
  • Paola Vigano’

20 September 2017

Uterine fibroids are the most common gynecologic benign tumors. Studies supporting a strong pregnancy-related growth of leiomyomas generally claimed a crucial role of sex steroid hormones. However, sex steroids are unlikely the unique actors involved...

  • Article
  • Open Access
28 Citations
8,611 Views
10 Pages

13 October 2016

Human chorionic gonadotropin (hCG) has been regarded as a biomarker for the diagnosis of pregnancy and some cancers. Because the currently used methods (e.g., disposable Point of Care Testing (POCT) device) for hCG detection require the use of many l...

  • Article
  • Open Access
9 Citations
2,614 Views
26 Pages

Comparison of Steroidogenic and Ovulation-Inducing Effects of Orthosteric and Allosteric Agonists of Luteinizing Hormone/Chorionic Gonadotropin Receptor in Immature Female Rats

  • Kira V. Derkach,
  • Ivan A. Lebedev,
  • Irina Yu. Morina,
  • Andrey A. Bakhtyukov,
  • Alena S. Pechalnova,
  • Viktor N. Sorokoumov,
  • Veronica S. Kuznetsova,
  • Irina V. Romanova and
  • Alexander O. Shpakov

22 November 2023

Gonadotropins, including human chorionic gonadotropin (hCG), are used to induce ovulation, but they have a number of side effects, including ovarian hyperstimulation syndrome (OHSS). A possible alternative is allosteric luteinizing hormone (LH)/hCG r...

  • Article
  • Open Access
5 Citations
4,007 Views
10 Pages

Cerebrospinal Fluid Levels of AFP and hCG: Validation of the Analytical Method and Application in the Diagnosis of Central Nervous System Germ Cell Tumors

  • Annamaria D'Alessandro,
  • Domenico Ciavardelli,
  • Anna Pastore,
  • Germana Giannone,
  • Giada Del Baldo,
  • Andrea Carai,
  • Angela Mastronuzzi,
  • Andrea Onetti Muda and
  • Ottavia Porzio

26 October 2021

The determination of Human Chorionic Gonadotropin (hCG) and Alpha Fetoprotein (AFP) levels on serum and amniotic fluid plays a fundamental role in the diagnosis and follow-up of specific physiological or pathological conditions (e.g., pregnancy, thre...

  • Article
  • Open Access
6 Citations
3,371 Views
16 Pages

Production of Mare Chorionic Girdle Organoids That Secrete Equine Chorionic Gonadotropin

  • Riley E. Thompson,
  • Mindy A. Meyers,
  • Jennifer Palmer,
  • D. N. Rao Veeramachaneni,
  • Christianne Magee,
  • Amanda M. de Mestre,
  • Douglas F. Antczak and
  • Fiona K. Hollinshead

The equine chorionic girdle is comprised of specialized invasive trophoblast cells that begin formation approximately 25 days after ovulation (day 0) and invade the endometrium to become endometrial cups. These specialized trophoblast cells transitio...

  • Perspective
  • Open Access
10 Citations
4,250 Views
9 Pages

Hyperglycosylated-hCG: Its Role in Trophoblast Invasion and Intrauterine Growth Restriction

  • Catalin Gabriel Herghelegiu,
  • Alina Veduta,
  • Miruna Florina Stefan,
  • Stefania Lucia Magda,
  • Iuliana Ionascu,
  • Viorica Elena Radoi,
  • Daniela Nuti Oprescu and
  • Alina Mihaela Calin

16 June 2023

Human chorionic gonadotropin (hCG) is produced by the placenta and its roles have been studied for over a century, being the first known pregnancy-related protein. Although its main role is to stimulate the production of progesterone by corpus luteal...

  • Systematic Review
  • Open Access
10 Citations
4,272 Views
13 Pages

23 April 2023

The circulation of progesterone (P4) concentrations of recipients has positive correlations with embryo survival and pregnancy success of embryo transfer (ET) in dairy cows. One strategy to improve P4 concentration is the administration of gonadotrop...

  • Article
  • Open Access
26 Citations
4,782 Views
28 Pages

Comparative Study of the Steroidogenic Effects of Human Chorionic Gonadotropin and Thieno[2,3-D]pyrimidine-Based Allosteric Agonist of Luteinizing Hormone Receptor in Young Adult, Aging and Diabetic Male Rats

  • Andrey A. Bakhtyukov,
  • Kira V. Derkach,
  • Maxim A. Gureev,
  • Dmitry V. Dar’in,
  • Viktor N. Sorokoumov,
  • Irina V. Romanova,
  • Irina Yu. Morina,
  • Anna M. Stepochkina and
  • Alexander O. Shpakov

11 October 2020

Low-molecular-weight agonists of luteinizing hormone (LH)/human chorionic gonadotropin (hCG) receptor (LHCGR), which interact with LHCGR transmembrane allosteric site and, in comparison with gonadotropins, more selectively activate intracellular effe...

  • Review
  • Open Access
44 Citations
11,837 Views
11 Pages

hCG and Its Disruption by Environmental Contaminants during Human Pregnancy

  • Luana Paulesu,
  • Ch.V. Rao,
  • Francesca Ietta,
  • Adalgisa Pietropolli and
  • Carlo Ticconi

Human chorionic gonadotropin (hCG) is a hormone of considerable importance in the establishment, promotion and maintenance of human pregnancy. It has been clearly demonstrated that hCG exerts multiple endocrine, paracrine and autocrine actions on a v...

  • Abstract
  • Open Access
1 Citations
1,410 Views
3 Pages

Gold nanotriangles (GNTs) for producing a test strip of human chorionic gonadotropin (hCG) tests were reported in this paper. The GNTs were simply synthesized by non-thermal liquid-phase reduction with sodium citrate and tannic acid composition as a...

  • Article
  • Open Access
12 Citations
5,875 Views
19 Pages

Exogenous Gonadotrophin Stimulation Induces Partial Maturation of Human Sertoli Cells in a Testicular Xenotransplantation Model for Fertility Preservation

  • Marsida Hutka,
  • Lee B. Smith,
  • Ellen Goossens,
  • W. Hamish B. Wallace,
  • Jan-Bernd Stukenborg and
  • Rod T. Mitchell

18 January 2020

The future fertility of prepubertal boys with cancer may be irreversibly compromised by chemotherapy and/or radiotherapy. Successful spermatogenesis has not been achieved following the xenotransplantation of prepubertal human testis tissue, which is...

  • Feature Paper
  • Article
  • Open Access
1,293 Views
12 Pages

Combined Effects of Human Chorionic Gonadotropin and Intravaginal Progesterone Device Treatment in the Early Luteal Phase After Artificial Insemination on Conception Rate in Lactating Dairy Cows

  • Ryotaro Miura,
  • Taiki Izumi,
  • Yuriko Wada,
  • Yujiro Hagita,
  • Kosuke Iga,
  • Natsumi Sobu,
  • Akiya Hirase,
  • Osamu Yoneyama,
  • Yo-ichi Miyake and
  • Motozumi Matsui
  • + 3 authors

30 May 2025

The combined effects of human chorionic gonadotropin (hCG) treatment on Day 5 (Day 0 = the day of artificial insemination: AI) and intravaginal progesterone device (IVPD) treatment from Day 5 to 19 on the conception rate and plasma sex steroid hormon...

  • Review
  • Open Access
465 Views
44 Pages

Molecular Crosstalk Between Intrauterine hCG and Endometrial Receptivity: Signalling Pathways, Immune Modulation, and Translational Perspectives in IVF

  • Charalampos Voros,
  • Fotios Chatzinikolaou,
  • Georgios Papadimas,
  • Spyridon Polykalas,
  • Aristotelis-Marios Koulakmanidis,
  • Diamantis Athanasiou,
  • Vasiliki Kanaka,
  • Maria Kanaka,
  • Kyriakos Bananis and
  • Georgios Daskalakis
  • + 9 authors

26 December 2025

A limited period of endometrial receptivity is defined by molecular interactions between the embryo and maternal tissues, which are crucial for successful implantation. The results of clinical studies assessing intrauterine human chorionic gonadotrop...

  • Article
  • Open Access
1 Citations
3,233 Views
14 Pages

The Role of β-Core Fragment hCG in Embryo Implantation and Early Pregnancy

  • Ji Soo Ryu,
  • Nu Ri Yang,
  • Yu Ha Shim,
  • Yu Jin Kim,
  • Won Jae Kwag,
  • Jin Dong Chang and
  • Jae Ho Lee

18 August 2025

Human chorionic gonadotropin (hCG) is a pregnancy biomarker, and five forms of this hormone are involved in female physiological regulation. β-core fragment hCG (bcf-hCG) is a fragment of hCG whose biological role in female reproduction has not...

  • Short Communication
  • Open Access
10 Citations
3,936 Views
8 Pages

The increase in progesterone (P4) levels on the day of human chorionic gonadotropin (hCG) administration have a negative effect on endometrial receptivity. There are few reports regarding the expression of homeobox A10 (HOXA10) as one of many biomole...

  • Article
  • Open Access
1 Citations
2,911 Views
15 Pages

Hormonal Management for the Induction of Luteolysis and Ovulation in Andalusian Jennies: Effect on Reproductive Performance, Embryo Quality and Recovery Rate

  • Marina Bottrel,
  • Isabel Ortiz,
  • Manuel Hidalgo,
  • María Díaz-Jiménez,
  • Blasa Pereira,
  • César Consuegra,
  • Mohamed Samy Yousef and
  • Jesús Dorado

8 January 2022

Two prostanglandins (luprostiol, LUP, and dinoprost, DIN) and two ovulation-inducing agents (human Chorionic Gonadotropin, hCG, and deslorelin, DES) were evaluated for luteolysis and estrus induction, and for ovulation induction, respectively, in emb...

  • Article
  • Open Access
9 Citations
4,074 Views
13 Pages

Effects of Elevated Progesterone Levels on the Day of hCG on the Quality of Oocyte and Embryo

  • Jeesoo Woo,
  • Hwang Kwon,
  • Donghee Choi,
  • Chan Park,
  • Jihyang Kim,
  • Jieun Shin,
  • Jeehyun Kim,
  • Youn-Jung Kang and
  • Hwaseon Koo

25 July 2022

This study is designed to investigate the effects of increased progesterone (P4) levels on the quality of retrieved oocytes and embryos during IVF. This retrospective analysis included 982 all-freezing in vitro fertilization (IVF) cycles (conducted b...

  • Review
  • Open Access
8 Citations
9,377 Views
19 Pages

Glycan Analysis as Biomarkers for Testicular Cancer

  • Michal Hires,
  • Eduard Jane,
  • Michal Mego,
  • Michal Chovanec,
  • Peter Kasak and
  • Jan Tkac

The U.S. Preventive Services Task Force does not recommend routine screening for testicular cancer (TC) in asymptomatic men, essentially because serological testicular cancer (TC) biomarkers are not reliable. The main reason is that two of the most i...

  • Communication
  • Open Access
4 Citations
2,477 Views
11 Pages

Quantification of hCG Hormone Using Tapered Optical Fiber Decorated with Gold Nanoparticles

  • David Saúl Villegas-Cantoran,
  • Celia Lizeth Gómez,
  • Luz del Carmen Gómez-Pavón,
  • Placido Zaca-Morán,
  • Dulce Natalia Castillo-López,
  • Arnulfo Luis-Ramos and
  • Jesús Manuel Muñoz-Pacheco

18 October 2023

In this study, a novel technique for the quantification of the human chorionic gonadotropin (hCG) hormone using localized surface plasmons and a tapered optical fiber decorated with gold nanoparticles (Au-NPs) is reported. The tapered optical fiber f...

  • Feature Paper
  • Article
  • Open Access
2 Citations
3,379 Views
16 Pages

Human Chorionic Gonadotropin Enhancement of Early Maturation and Consequences for Reproductive Success of Feminized European Eel (Anguilla anguilla)

  • Arjan P. Palstra,
  • Ida van de Ven,
  • Pauline Jéhannet,
  • Leo Kruijt,
  • Henk Schipper,
  • William Swinkels and
  • Leon T. N. Heinsbroek

25 May 2023

To induce oocyte development, eels are weekly injected with salmon or carp pituitary extract (CPE). The weekly handling and hormone peaks result in inferior oocyte quality; therefore, alternative treatments that improve oocyte quality and reproductiv...

  • Article
  • Open Access
12 Citations
7,307 Views
16 Pages

5 June 2014

The analysis of human chorionic gonadotropin (hCG) in clinical chemistry laboratories by specific immunoassay is well established. However, changes in glycosylation are not as easily assayed and yet alterations in hCG glycosylation is associated with...

  • Article
  • Open Access
11 Citations
4,649 Views
15 Pages

Expression of Transcripts in Marmoset Oocytes Retrieved during Follicle Isolation Without Gonadotropin Induction

  • Yoon Young Kim,
  • Byeong-Cheol Kang,
  • Jun Won Yun,
  • Jae Hun Ahn,
  • Yong Jin Kim,
  • Hoon Kim,
  • Zev Rosenwaks and
  • Seung-Yup Ku

The in vitro maturation of oocytes is frequently used as an assisted reproductive technique (ART), and has been successfully established in humans and rodents. To overcome the limitations of ART, novel procedures for the in vitro maturation of early...

  • Article
  • Open Access
11 Citations
3,175 Views
13 Pages

Potential Significance of Serum Autoantibodies to Endometrial Antigens, α-Enolase and Hormones in Non-Invasive Diagnosis and Pathogenesis of Endometriosis

  • Irina V. Menzhinskaya,
  • Stanislav V. Pavlovich,
  • Arika G. Melkumyan,
  • Vladimir D. Chuprynin,
  • Ekaterina L. Yarotskaya and
  • Gennady T. Sukhikh

25 October 2023

The objective of the study was to evaluate the profile of serum autoantibodies and their diagnostic and pathogenetic significance in ovarian endometrioma (OEM) and deep infiltrative endometriosis (DIE). The study enrolled 74 patients with endometrios...

  • Article
  • Open Access
53 Citations
10,533 Views
13 Pages

Label-Free Sensors Based on Graphene Field-Effect Transistors for the Detection of Human Chorionic Gonadotropin Cancer Risk Biomarker

  • Carrie Haslam,
  • Samar Damiati,
  • Toby Whitley,
  • Paul Davey,
  • Emmanuel Ifeachor and
  • Shakil A. Awan

We report on the development of label-free chemical vapour deposition (CVD) graphene field effect transistor (GFET) immunosensors for the sensitive detection of Human Chorionic Gonadotropin (hCG), a glycoprotein risk biomarker of certain cancers. Th...

  • Article
  • Open Access
13 Citations
9,741 Views
11 Pages

1 September 2014

This study presents an optical inspection system for detecting a commercial point-of-care testing product and a new detection model covering from qualitative to quantitative analysis. Human chorionic gonadotropin (hCG) strips (cut-off value of the hC...

  • Article
  • Open Access
8 Citations
8,623 Views
14 Pages

20 August 2015

A simple DNA-redox cation interaction enhancement strategy has been developed to improve the sensitivity of electrochemical immunosensors for protein detection. Instead of labeling with fluorophores or redox-active groups, the detection antibodies we...

  • Article
  • Open Access
67 Citations
7,342 Views
16 Pages

Estrogen Modulates Specific Life and Death Signals Induced by LH and hCG in Human Primary Granulosa Cells In Vitro

  • Livio Casarini,
  • Laura Riccetti,
  • Francesco De Pascali,
  • Lisa Gilioli,
  • Marco Marino,
  • Eugenia Vecchi,
  • Daria Morini,
  • Alessia Nicoli,
  • Giovanni Battista La Sala and
  • Manuela Simoni

Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) are glycoprotein hormones used for assisted reproduction acting on the same receptor (LHCGR) and mediating different intracellular signaling. We evaluated the pro- and anti-apoptotic eff...

  • Article
  • Open Access
3 Citations
2,412 Views
13 Pages

5 July 2024

The feedback regulatory effects of estrogen (E2) and androgen (T) on the gonadotropin-releasing hormone (GnRH) and gonadotropin (GtH) within the brain–pituitary–gonad (BPG) axis in eels with undeveloped ovaries were investigated through i...

  • Article
  • Open Access
41 Citations
5,042 Views
35 Pages

The Effects of Separate and Combined Treatment of Male Rats with Type 2 Diabetes with Metformin and Orthosteric and Allosteric Agonists of Luteinizing Hormone Receptor on Steroidogenesis and Spermatogenesis

  • Andrey A. Bakhtyukov,
  • Kira V. Derkach,
  • Viktor N. Sorokoumov,
  • Anna M. Stepochkina,
  • Irina V. Romanova,
  • Irina Yu. Morina,
  • Irina O. Zakharova,
  • Liubov V. Bayunova and
  • Alexander O. Shpakov

24 December 2021

In men with type 2 diabetes mellitus (T2DM), steroidogenesis and spermatogenesis are impaired. Metformin and the agonists of luteinizing hormone/human chorionic gonadotropin(hCG)-receptor (LH/hCG-R) (hCG, low-molecular-weight allosteric LH/hCG-R-agon...

  • Article
  • Open Access
2,593 Views
12 Pages

4 September 2023

The genus Alytes consists of six primitive terrestrial-breeding species (five of them endangered or present in restricted distributions) with unique male parental care. Alytes obstetricans was used as a model for the development of assisted reproduct...

  • Review
  • Open Access
2 Citations
4,874 Views
28 Pages

Is Human Chorionic Gonadotropin a Reliable Marker for Testicular Germ Cell Tumor? New Perspectives for a More Accurate Diagnosis

  • Nunzio Marroncelli,
  • Giulia Ambrosini,
  • Andrea Errico,
  • Sara Vinco,
  • Elisa Dalla Pozza,
  • Giulia Cogo,
  • Ilaria Cristanini,
  • Filippo Migliorini,
  • Nicola Zampieri and
  • Ilaria Dando

21 July 2025

Testicular germ cell tumors (TGCTs) are the most common malignancies affecting young men between the ages of 14 and 44, accounting for about 95% of all testicular cancers. Despite being relatively rare compared to other cancers (~3.0 cases per 100,00...

  • Review
  • Open Access
21 Citations
10,149 Views
19 Pages

Follicle-Stimulating Hormone Biological Products: Does Potency Predict Clinical Efficacy?

  • Monica Lispi,
  • Peter Humaidan,
  • George R. Bousfield,
  • Thomas D’Hooghe and
  • Alfredo Ulloa-Aguirre

Follicle-stimulating hormone (FSH), together with luteinizing hormone (LH) and human chorionic gonadotropin (hCG), plays a fundamental role in human reproduction. The discovery of FSH and other gonadotropins was a defining moment in our understanding...

  • Review
  • Open Access
13 Citations
7,936 Views
13 Pages

Does Intrauterine Injection of hCG Improve IVF Outcome? A Systematic Review and a Meta-Analysis

  • Alessandro Conforti,
  • Salvatore Longobardi,
  • Luigi Carbone,
  • Giuseppe Gabriele Iorio,
  • Federica Cariati,
  • Maria Rosaria Campitiello,
  • Ida Strina,
  • Michela Palese,
  • Thomas D’Hooghe and
  • Carlo Alviggi

13 October 2022

Various interventions have been proposed to improve embryo implantation in IVF. Among these, intrauterine injections of human chorionic gonadotropin seem to have promising results. Consequently, we conducted a review and meta-analysis to assess IVF o...

  • Article
  • Open Access
8 Citations
4,389 Views
11 Pages

The Study of the Expression of CGB1 and CGB2 in Human Cancer Tissues

  • Piotr Białas,
  • Aleksandra Śliwa,
  • Anna Szczerba and
  • Anna Jankowska

17 September 2020

Human chorionic gonadotropin (hCG) is a well-known hormone produced by the trophoblast during pregnancy as well as by both trophoblastic and non-trophoblastic tumors. hCG is built from two subunits: α (hCGα) and β (hCGβ). The ho...

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