Search Results (252)

Modern lifestyles are increasingly plagued by physical inactivity, social disconnection, digital addiction, and excessive time indoors—factors that negatively impact the health and well-being of both humans and their companion dogs (Canis familiaris). Evidence shows that nature exposure, physical activity, and human–animal bond (HAB) each enhance physical, mental, and social well-being, yet these domains have rarely been examined together as an integrated therapeutic triad. We introduce a new conceptual framework of bonded green exercise, defined as shared physical activity between a bonded human and dog in natural environments. Synthesizing existing evidence across human and canine sciences into a testable conceptual integration, we posit that bonded green exercise may plausibly activate evolutionarily conserved, synergistic mechanisms of physiological, behavioural, and affective co-regulation. Four testable hypotheses are proposed: (H1) triadic synergy: combined domains produce greater benefits than additive effects; (H2) heterospecific benefit: parallel health gains occur in both species; (H3) behavioural amplification: dogs acts as catalysts to drive human participation in nature-based activity; and (H4) scalable health promotion: bonded green exercise represents a low-cost, accessible, One Health approach with population-level potential. This framework highlights how intentional, shared physical activity in nature may potentially offer a novel low-cost and accessible model for enhancing health, lifespan, welfare, and ecological stewardship across species. Full article

Patulin (PAT) is a fatal mycotoxin that exerts serious threats to human and animal health. Biodegradation of PAT is considered to be one of the promising ways for controlling its contamination. In this study, Lactiplantibacillus plantarum 6076 (LP 6076) with reliable removal efficiency on PAT was screened out from three lactic acid bacteria (LAB) strains. It was found that the PAT was eliminated through degradation by LP 6076, and the intracellular proteins played a crucial role in PAT degradation with the induction of PAT. The proteomic analysis showed that the response of LP 6076 to PAT was by a concerted effort to repair DNA damage, in parallel to adaptive changes in cell wall biosynthesis and central metabolism. Eleven differentially expressed proteins with high fold changes were picked out and identified as PAT degradation candidate enzymes. The 3D structures of the candidate enzymes were predicted, and molecular docking between the enzymes and PAT was performed. Five enzymes, including Acetoin utilization AcuB protein (AU), GHKL domain-containing protein (GHLK), Dihydroneopterin aldolase (DA), YdeI/OmpD-associated family protein (YDEL), and Transcription regulator protein (TR), could dock with PAT with lower affinity and shorter distance. Through molecular docking analysis, DA was ultimately identified as a potential key degrading enzyme. The choice of DA was substantiated by its superior combination of strong binding affinity and a productive binding pose with PAT. VAL84 and GLN51 residues of DA were likely the active sites, forming four hydrogen bonds with PAT. Our study could accelerate the commercial application of biodegradation toward PAT decontamination. Full article

Animal-assisted services (AAS) depend on volunteer handler–dog teams, yet the emotional and relational impacts on volunteers when their therapy dog dies or retires remain largely unexplored. This study examines AAS volunteers’ experiences following the death or retirement of their therapy dog partner. An online, anonymous cross-sectional survey was administered between January and June 2025. A total of 247 individual responses were analyzed. Over half of survey participants (56%) had lost a therapy dog to death, and 36.6% had retired a dog. Although most volunteers who resumed AAS with a new dog reported excitement and renewed purpose, many experienced sadness linked to their previous partner. Retirement decisions were primarily driven by dog welfare concerns and were often experienced as an ambiguous loss. Social constraints were common; participants frequently perceived minimization or discomfort from others when attempting to discuss their grief. In conclusion, therapy dog death and retirement represent significant emotional and relational losses for AAS volunteers. Organizational practices, including anticipatory retirement planning, welfare-centered guidelines, recognition rituals, and structured support during successor-dog transitions may help mitigate distress and foster healthy adjustment. Findings are discussed in relation to theory-informed, practical implications for animal-assisted service practitioners and organizations. Full article

Research suggests that older adults might obtain health benefits from pet ownership; however, results are mixed. Pet attachment is suggested as both a mechanism for the relationship and a reason for differences in the association of pet ownership with health outcomes. This systematic review examines evidence for the relationship between pet attachment and health outcomes among older adults. The Open Science Foundation-registered review began with 20,795 candidate articles. We limited our review to the 58 articles that consisted of original research, published in peer-reviewed journals between 1965 and June 2025, written in English, included older adults (age ≥ 50 years) or were limited to only older adults, and examined the relationship between pet attachment and health outcomes. The articles included analyses of psychological (n = 53), social (n = 27), or physical (n = 2) health outcomes. Pet attachment was assessed with 19 tools; most frequently the Lexington Attachment to Pets Scale (n = 21) and the Pet Attachment Questionnaire (n = 8). The studies were not consistently of high quality according to OCEBM criteria. Except for grief, which was consistently related to pet attachment, the findings do not support a clear relationship between pet attachment and health outcomes in older adults. Findings suggest that the relationship between pet attachment and health outcomes may be more pronounced in younger than in older adults. Full article

The love for horses is deeply rooted in human history and culture, captivating us with their magnificent nature. For millennia, horses have been crucial to human survival and development, providing transportation, labor, and even status. Currently, interest in human relationships with other animals has grown significantly, in the context of promoting the well-being and essential health of both species. This entry aims to explore the possibilities of human–horse relationships, from early interactions to strong bonds. The literature collected here highlights the complexity of this relationship, with special attention to the various biological and social factors involved. The text compares historical practices with current perspectives, examining how these changes affect the relationship between humans and horses. It examines how connecting with horses potentially benefits both humans and horses, underlining the importance of recognizing horse behavior and noting that our assumptions may not reflect their true needs. This literature enriches our understanding of the multifaceted nature of human–horse relationships, offering a new perspective on horse care, which focuses on positive relationship and well-being, and therefore on the importance of harmonious provision of all domains of well-being, highlighting the importance of healthy behavioral interactions and emotional stability of both species. Full article

The H3N8 low pathogenic avian influenza virus (LPAIV) exhibits broad host tropism, infecting diverse avian and mammalian species, raising concerns about its zoonotic potential. Following the emergence of human infections with H3N8 LPAIV in China, including a fatal case, we investigated the epidemiological and virological characteristics of this virus in Guangdong Province. In 2022, a serological survey revealed H3N8 seroprevalence rates of 10.85% in farmed chickens and 7.97% in ducks. We isolated three H3N8 viruses, designated as A/chicken/Qingyuan/22/2022 (H3N8); A/chicken/Qingyuan/31/2022 (H3N8); and A/chicken/Qingyuan/15/2022 (H3N8), and found that these chicken isolates, like the human isolate A/Changsha/1000/2022, share the same E190 residue. This residue can synergize with sites such as Q226 and G228 to enhance binding affinity for SAα-2,6-Gal. Additionally, they harbor the three amino acid residues N193, W222, and S227. Among these, N193 has the potential to form hydrogen bonds with α2-6-linked glycans, while W222 and S227 may alter the conformational flexibility of the 220-loop. These two effects collectively endow the H3N8 isolates with dual receptor-binding properties. These findings suggest a shift in receptor specificity, potentially facilitating viral adaptation to mammalian hosts. Characterization of viral genome detection dynamics, and histopathology in animal models further elucidated the viral infection dynamics. Our study provides critical insights into the evolutionary trajectory and zoonotic potential of the H3N8 LPAIV. Full article

Dogs are often viewed as family members, and many owners describe them as “fur babies.” However, little is known about how women with and without children perceive and practice caregiving toward their dogs, and how these experiences relate to parenting. This qualitative study explored the meanings of dog and child caregiving among 28 dog-owning women (13 mothers and 15 childless) through semi-structured interviews. All participants had lived with their dog for at least one year. Thematic analysis identified five main themes: (1) emotional meanings and motivations of caregiving, (2) practical caregiving and daily routines, (3) responsibility and dependency, (4) social relationships and support, and (5) life course perspectives. Both mothers and non-mothers described their dogs as sources of joy, companionship, and unconditional love. Women without children often saw their dogs as child substitutes, while mothers stressed the greater responsibility and permanence of raising children. Dog ownership and parenting influenced social life and work differently: dogs often increased social interaction and offered flexibility, whereas children introduced stricter routines and reduced spontaneity. Overall, dogs fulfilled important emotional and caregiving needs, particularly among women without children, but did not replace the unique social and moral responsibilities of parenting. Full article

In recent years, the socio-legal concept of emotional support animals (ESAs) has come under increasing scrutiny in the U.S. Widespread confusion about the legal status of ESAs versus service animals and concerns about misrepresentation have resulted in a backlash and a cascade of new legislation addressing “fake service animals.” However, this reaction reveals a broader social problem rooted in policy lag: the integration of companion animals into society has not kept pace with the rise of multispecies families. This article examines law, policy, and public discourse about ESAs within two distinct social contexts: (1) the emergence of multispecies families alongside the systemic exclusion of companion animals from many private and public spaces, and (2) the medicalization of relational bonds and everyday life. Although well-intentioned, the legal and social construction of ESAs creates a two-tiered system where caregivers of companion animals must acquire a medical diagnosis in order to obtain equal access to basic necessities like housing. In addition to resting on weak evidence, the ESA framework diverts attention from macro social issues by pathologizing the individual, creating a problematic medicalization of the human-animal bond that is ultimately detrimental to the well-being of companion animals, their caregivers, and people with disabilities. The construct is also troublingly anthropocentric, centering what animals can do for humans without considering the psychological and emotional support needs of the animals themselves. This article concludes that the anthropocentric medical model advanced by the ESA construct should be replaced with a multispecies social model that supports the human-animal bond without unnecessary medicalization. This approach advocates for equitable laws and policies, such as the expansion of pet-inclusive housing, that benefit families that include companion animals and the communities in which they are embedded. Full article

Humans show neural specificity in processing animal-related information, especially regarding companion animals. However, the underlying cognitive mechanisms remain poorly understood. This study’s main objective is to investigate human neural specificity in processing companion animal-related information, compared to other animal types and inanimate objects. Forty participants viewed four image types (companion animals, neutral animals, positive objects, neutral objects) during functional magnetic resonance imaging (fMRI) scans and judged image categories. T-test results showed: 1. Processing companion animal-related information elicited specific brain activation in the right Inferior Parietal Lobe (right IPL), right Middle Occipital Gyrus (right MOG), left Superior Frontal Gyrus (left SFG), and left Precuneus (left PCu) (<0.05). 2. Generalized Psychophysiological Interaction (gPPI) analysis revealed specific functional connectivity changes between relevant brain regions during companion animal info processing (<0.05). 3. Dynamic Causal Modelling (DCM) analysis showed significant intrinsic connectivity differences between pet owners and non-pet owners: specifically, left IPL to left PCu and right ACC to right MOG (posterior probability, Pp > 0.95). The results of this study demonstrate that humans exhibit distinct neural specificity when processing information related to companion animals compared with livestock and inanimate objects. This neural specificity involves brain regions linked to higher-order cognitive functions (e.g., visual processing, emotion, and attachment), all of which are integral components of the human attachment network. These regions are part of the human attachment network, and their functional role likely relates to attachment mechanisms. These findings help clarify companion animals’ impact on human neural activity during human–animal interactions and guide applications like animal-assisted therapy. Full article

A key diagnostic tool in breeding practice is systematic observation: by identifying abnormalities in natural behaviour, it can highlight early signs of reduced welfare or physical and mental health issues in livestock and other animals. The aim of this paper is to review current literature to provide a detailed analysis of the factors affecting the physical and mental health of alpacas (Vicugna pacos) with regard to their husbandry method. It analyses various behavioural patterns such as stress reactions to strangers, isolation and grooming, as well as social interactions (hierarchy, bonding, affiliative and aggressive behaviour), reproductive activity (courtship, copulation, partner rejection), and resting and foraging rhythms. It also discusses the influence of socialisation on human–animal relationships and the role of the environment, and its enrichment, in proper behavioural functioning. It also examines the significant role played by nutrition and the environment in ensuring alpaca welfare, and how it can be maintained during grooming and training. It pays special attention to the use of behavioural tests to assess the level of trust and tameness in alpacas. Systematic behaviour observation allows a quick response to deteriorating welfare, thus facilitating more efficient herd management and reducing the risk of more serious health and behavioural problems. Full article

Background/Objectives: Dogs are widely regarded as reliable sources of companionship and emotional support. In many instances, they are not merely considered pets, but valued as integral members of the family who significantly influence their caregivers’ emotional and psychological health. Within this framework, this research examines how dog ownership through adoption may serve as both a protective and empowering factor against feelings of loneliness, while also fostering emotional resilience and a renewed sense of purpose in everyday life. Methods: Employing a qualitative research design, this study involved ten Greek participants, five women and five men, aged between 26 and 72, all of whom were the primary caregivers of their dogs. Data were collected through semi-structured interviews aimed at eliciting rich, in-depth personal narratives. Thematic analysis was used to identify recurring emotional patterns and explore the meanings embedded in participants’ accounts. Results: The findings revealed that the human–dog bond functions as a stable emotional anchor, promoting non-judgmental connection and emotional security. Participants reported experiencing greater emotional expression, enhanced social engagement, and improved psychological balance. Conclusions: Overall, the results demonstrate how dog ownership through adoption may act as a protective factor against loneliness while fostering resilience and emotional balance, pointing to the broader mental health benefits of nurturing human–animal bonds. Full article

Pet humanization, particularly in dogs and cats, has transformed animal healthcare and highlighted the importance of nutrition in promoting human–pet social interaction, pet psychophysical well-being and, possibly, longevity. Nutraceuticals, such as omega-3 fatty acids, prebiotics, probiotics, plant extracts and dietary supplements, are endowed with antioxidant, anti-inflammatory, immune-modulating, cognitive-enhancing and gut-microbiota balancing properties. These effects have been shown to contribute to the possible prevention and management of bone and skin diseases, as well as gastrointestinal and behavioral disturbs. Moreover, the human–animal bond has been shown to play a pivotal role in reducing stress, improving sociability, and modulating pets’ emotional and physiological states. Evidence also suggests that nutrition and social interactions can influence the gut–brain axis, impacting the behavior, cognition, and resilience to stress-related disorders. Besides underlining the value of nutraceutical integration into pet nutrition strategies and offering a comprehensive, evidence-based perspective on their potential in improving animal welfare, literature reports about drawbacks of the use/misuse of such substances have been reported. Full article

In recent years, apatite-based materials have garnered significant interest, particularly for applications in tissue engineering. Apatite is most commonly employed as a coating for metallic implants, as a component in composite materials, and as scaffolds for bone and dental tissue regeneration. Among its various forms, hydroxyapatite (HAP) is the most widely used, owing to its natural occurrence in human and animal hard tissues. An emerging area of research involves the use of fluoride-substituted apatite, particularly fluorapatite (FAP), which can serve as a direct fluoride source at the implant site, potentially offering several biological and therapeutic advantages. However, substituting HAP with FAP may lead to unforeseen changes in material behavior due to the differing physicochemical properties of these two calcium phosphate phases. This study investigates the effects of replacing hydroxyapatite with fluorapatite in ceramic–polymer composite materials incorporating β-1,3-glucan as a bioactive polymeric binder. The β-1,3-glucan polysaccharide was selected for its proven biocompatibility, biodegradability, and ability to form stable hydrogels that promote cellular interactions. Nitrogen adsorption analysis revealed that FAP/glucan composites had a significantly lower specific surface area (0.5 m²/g) and total pore volume (0.002 cm³/g) compared to HAP/glucan composites (14.15 m²/g and 0.03 cm³/g, respectively), indicating enhanced ceramic–polymer interactions in fluoride-containing systems. Optical profilometry measurements showed statistically significant differences in profile parameters (e.g., Rp: 134 μm for HAP/glucan vs. 352 μm for FAP/glucan), although average roughness (Ra) remained similar (34.1 vs. 27.6 μm, respectively). Microscopic evaluation showed that FAP/glucan composites had smaller particle sizes (1 μm) than their HAP counterparts (2 μm), despite larger primary crystal sizes in FAP, as confirmed by TEM. XRD analysis indicated structural differences between the apatites, with FAP exhibiting a reduced unit cell volume (524.6 ų) compared to HAP (528.2 ų), due to substitution of hydroxyl groups with fluoride ions. Spectroscopic analyses (FTIR, Raman, ³¹P NMR) confirmed chemical shifts associated with fluorine incorporation and revealed distinct ceramic–polymer interfacial behaviors, including an upfield shift of PO₄³⁻ bands (964 cm⁻¹ in FAP vs. 961 cm⁻¹ in HAP) and OH vibration shifts (3537 cm⁻¹ in FAP vs. 3573 cm⁻¹ in HAP). The glucan polymer showed different hydrogen bonding patterns when combined with FAP versus HAP, as evidenced by shifts in polymer-specific bands at 888 cm⁻¹ and 1157 cm⁻¹, demonstrating that fluoride substitution significantly influences ceramic–polymer interactions in these bioactive composite systems. Full article

Despite the growing preference for cats as companion animals, beliefs and misperceptions about them are still common. Cultural and sociodemographic aspects can influence society’s attitudes towards cats, affecting the way they are kept and cared for and, consequently, their welfare. This narrative review aimed to identify and categorize beliefs and misconceptions about domestic cats commonly described in the scientific literature, particularly those related to behavior, sociality, health, and management, in order to foster critical thinking about these perceptions. Our bibliographic search included three electronic databases (Web of Science, PubMed and Scopus). This review highlights a set of recurrent beliefs of general society reported by the scientific literature, such as the perception of cats as independent and non-social animals, bringers of bad luck, incapable of forming emotional bonds with their guardians, or in need of outdoor access to thrive. Although widespread, many of these beliefs lack empirical support. Identifying and fostering critical reflection on such beliefs can contribute to deconstructing them, improving the guardian–cat relationship and enhancing the welfare of both cats and humans. Full article

This study investigated the effects of low-dose 1cp-LSD, a prodrug of LSD, on canine anxiety, while exploring the influence of owner psychopathology on treatment outcomes. Seven dogs exhibiting anxiety-related behaviors were recruited and received 2.5, 5, or 10 µg of 1cp-LSD orally every three days for 30 days. One additional dog, which did not meet clinical criteria for anxiety but whose owner perceived it as anxious, received a placebo (saccharin) as an observational case. Anxiety levels were assessed using validated scales at baseline, post-treatment, and one month after treatment cessation. Owners’ neuroticism and psychopathological dimensions were evaluated using the IPIP and SA-45 scales. Linear regression analyses examined associations between anxiety reduction, administered dose, and owner psychological traits. A significant reduction in separation anxiety scores was observed post-treatment (mean: 11.3 ± 3.0, p = 0.023). Higher 1cp-LSD doses correlated with greater anxiety reduction (B = −1.15, 95% CI = [−2.29, −0.003], p = 0.050). Additionally, higher owner psychoticism scores were associated with smaller improvements in canine anxiety (p = 0.035). Anxiety levels remained low one month after treatment, with significant associations between canine anxiety and the owners’ hostility, interpersonal sensitivity, and paranoid ideation. These findings support the potential role of low-dose serotonergic psychedelics in managing canine anxiety and suggest an association between caregiver psychological traits and treatment outcomes. The sustained reduction in anxiety behaviors also suggests a meaningful and lasting improvement in animal welfare. However, significant results should be interpreted cautiously due to the small sample size. Further blinded, controlled studies are needed to validate these preliminary observations and assess broader applications in veterinary behavioral medicine. Full article