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272 Results Found

  • Article
  • Open Access
13 Citations
1,796 Views
18 Pages

30 September 2024

In the dynamic arena of healthcare research, where the complexities of data often rival the intricacies of biological systems, the ability to model and analyze such multifaceted datasets is crucial. This comprehensive review delves into the evolution...

  • Feature Paper
  • Article
  • Open Access
2 Citations
2,805 Views
29 Pages

Stochastic Claims Reserve in the Healthcare System: A Methodology Applied to Italian Data

  • Claudio Mazzi,
  • Angelo Damone,
  • Andrea Vandelli,
  • Gastone Ciuti and
  • Milena Vainieri

29 January 2024

One of the challenges in the healthcare sector is making accurate forecasts across insurance years for claims reserve. Healthcare claims present huge variability and heterogeneity influenced by random decisions of the courts and intrinsic characteris...

  • Article
  • Open Access
5 Citations
2,761 Views
13 Pages

Are Tumor Marker Tests Applied Appropriately in Clinical Practice? A Healthcare Claims Data Analysis

  • Sabrina M. Stollberg,
  • Markus Näpflin,
  • Michael Nagler and
  • Carola A. Huber

3 November 2023

Tumor markers (TM) are crucial in the monitoring of cancer treatment. However, inappropriate requests for screening reasons have a high risk of false positive and negative findings, which can lead to patient anxiety and unnecessary follow-up examinat...

  • Article
  • Open Access
2 Citations
3,154 Views
11 Pages

13 July 2022

There is empirical evidence of an association between periodontitis and coronary heart disease (CHD). However, it is uncertain whether periodontal treatment in CHD patients might lead to reduced healthcare costs. This study aims to assess the associa...

  • Article
  • Open Access
52 Citations
39,122 Views
11 Pages

5 September 2023

Healthcare fraud is intentionally submitting false claims or producing misinterpretation of facts to obtain entitlement payments. Thus, it wastes healthcare financial resources and increases healthcare costs. Subsequently, fraud poses a substantial f...

  • Article
  • Open Access
680 Views
17 Pages

12 September 2025

Background/Objectives: Type 2 Diabetes (T2D) computable phenotypes, which leverage electronic health records (EHRs) and administrative claims data, provide the basis for T2D population health research. Our study investigates how T2D phenotypes affect...

  • Communication
  • Open Access
1,400 Views
16 Pages

South Tyrol Healthcare Company: A Look at a Peculiar Model of Claims Management in Italy and Analysis of Its Last 11 Years

  • Martina Zanon,
  • Francesco Randazzo,
  • Valter Equisetto,
  • Paolo Martini,
  • Silvia Winkler,
  • Christian Leuprecht,
  • Stephan Vale,
  • Antonia Tessadri,
  • Monica Concato and
  • Stefano D’Errico

Background: Alternative Disputes Resolution (ADR) systems are becoming increasingly important tools in recent years for the management and resolution of health responsibility cases, but their dissemination and efficiency are still poorly described. T...

  • Article
  • Open Access
2 Citations
1,883 Views
9 Pages

Validation of Claims Data for Absorbing Pads as a Measure for Urinary Incontinence after Radical Prostatectomy, a National Cross-Sectional Analysis

  • Diederik J. H. Baas,
  • Jan Reitsma,
  • Lieke van Gerwen,
  • Jaron Vleghaar,
  • Jolanda M. L. G. Gehlen,
  • Cathelijne M. P. Ziedses des Plantes,
  • Jean Paul A. van Basten,
  • Roderick C. N. van den Bergh,
  • H. Max Bruins and
  • Eelco R. P. Collette
  • + 12 authors

7 December 2023

The use of healthcare insurance claims data for urinary incontinence (UI) pads has the potential to serve as an objective measure for assessing post-radical prostatectomy UI rates, but its validity for this purpose has not been established. The aim o...

  • Article
  • Open Access
6 Citations
3,885 Views
16 Pages

Use of Drug Claims Data and a Medication Risk Score to Assess the Impact of CYP2D6 Drug Interactions among Opioid Users on Healthcare Costs

  • Veronique Michaud,
  • Ravil Bikmetov,
  • Matt K. Smith,
  • Pamela Dow,
  • Lucy I. Darakjian,
  • Malavika Deodhar,
  • Brian Cicali,
  • Kevin T. Bain and
  • Jacques Turgeon

10 November 2021

Cytochrome P450 2D6 (CYP2D6) activity is highly variable due to several factors, including genetic polymorphisms and drug-drug-gene interactions. Hydrocodone, oxycodone, codeine, and tramadol the most commonly prescribed CYP2D6-activated opioids for...

  • Article
  • Open Access
4 Citations
3,139 Views
11 Pages

Mors Gaudet Succurrere Vitae. The Role of Clinical Autopsy in Preventing Litigation Related to the Management of Liver and Digestive Disorders

  • Stefano D’Errico,
  • Martina Zanon,
  • Michela Peruch,
  • Monica Concato,
  • Martina Padovano,
  • Alessandro Santurro,
  • Matteo Scopetti and
  • Vittorio Fineschi

Over the last 50 years, the number of clinical autopsies has decreased, but their role in assessing cause of death and clinical performance is still acknowledged. Few publications have studied their role in malpractice claim prevention. The paper aim...

  • Article
  • Open Access
853 Views
24 Pages

8 October 2025

Hospital fraud detection has often relied on periodic audits that miss evolving, internet-mediated patterns in electronic claims. An artificial intelligence and machine learning pipeline is being developed that is leakage-safe, imbalance aware, and a...

  • Article
  • Open Access
1,551 Views
18 Pages

Background: Existing research highlights the necessity of tailoring cost-containment policies to specific treatments due to the varying benefits across different diseases. This study contributes additional insights by examining the impact of such pol...

  • Article
  • Open Access
2,428 Views
17 Pages

Comparison of Fracture Identification Using Different Definitions in Healthcare Administrative (Claims) Data

  • Natalia Konstantelos,
  • Andrea M. Burden,
  • Angela M. Cheung,
  • Sandra Kim,
  • Paul Grootendorst and
  • Suzanne M. Cadarette

14 March 2023

We identified inconsistency in fracture definitions in a prior review of studies that utilized claims data. Here, we aimed to compare fracture rates estimated using thirteen hip and seven radius/ulna fracture definitions. Our primary analysis compare...

  • Article
  • Open Access
4 Citations
6,140 Views
22 Pages

A Deep Learning Model for Detecting Fake Medical Images to Mitigate Financial Insurance Fraud

  • Muhammad Asad Arshed,
  • Shahzad Mumtaz,
  • Ștefan Cristian Gherghina,
  • Neelam Urooj,
  • Saeed Ahmed and
  • Christine Dewi

Artificial Intelligence and Deepfake Technologies have brought a new dimension to the generation of fake data, making it easier and faster than ever before—this fake data could include text, images, sounds, videos, etc. This has brought new cha...

  • Article
  • Open Access
8 Citations
5,162 Views
9 Pages

Anti-tumor necrosis factor-α (anti-TNFα) agents are used for induction and maintenance of remission in patients with inflammatory bowel diseases (IBD). However, biologic drugs present a large economic burden on health insurance systems. W...

  • Article
  • Open Access
1 Citations
3,033 Views
11 Pages

13 April 2023

This retrospective cohort study assessed treatment changes and prognoses after incident drug-induced parkinsonism (DIP). We used the National Health Insurance Service’s National Sample Cohort database in South Korea. We selected patients diagno...

  • Article
  • Open Access
8 Citations
3,276 Views
18 Pages

Breast Cancer Care Pathways for Women with Preexisting Severe Mental Disorders: Evidence of Disparities in France?

  • Anna-Veera Seppänen,
  • Fabien Daniel,
  • Sophie Houzard,
  • Christine Le Bihan,
  • Magali Coldefy and
  • Coralie Gandré

4 January 2023

The excess cancer mortality in persons with severe mental illness (SMI) has been well documented, and research suggests that it may be influenced by care-related factors. Our objective was to assess breast cancer care pathways in women with SMI in Fr...

  • Article
  • Open Access
7 Citations
4,402 Views
16 Pages

9 May 2022

We used a real-world database (GuardantINFORMTM) to analyze the treatment choices for patients with mCRC who underwent next-generation sequencing of circulating tumor DNA (ctDNA) using a commercially available test (Guardant360®) after first- or...

  • Article
  • Open Access
2 Citations
2,949 Views
14 Pages

22 April 2024

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are novel oral anti-hyperglycemic drugs that demonstrate cardiovascular and metabolic benefits for patients with type 2 diabetes (T2D), heart failure (HF), and chronic kidney disease (CKD). There is...

  • Article
  • Open Access
1 Citations
1,457 Views
16 Pages

Association of Immune-Mediated Inflammatory Diseases and Fracture Risk in Patients with Type 2 Diabetes: A Nationwide Population-Based Study

  • Yuna Kim,
  • Oh Chan Kwon,
  • Ryul Kim,
  • Jong Hoon Kim,
  • Min-Jae Kim,
  • Min-Chan Park,
  • Jie-Hyun Kim,
  • Young Hoon Youn,
  • Hyojin Park and
  • Kyungdo Han
  • + 1 author

25 January 2025

Background: Immune-mediated inflammatory diseases (IMIDs) are associated with chronic inflammation that may increase fracture risk; however, their impact within specific populations, such as those with type 2 diabetes mellitus (T2DM), remains unclear...

  • Article
  • Open Access
1 Citations
1,381 Views
10 Pages

Real-World Antifungal Therapy Patterns Across the Continuum of Care in United States Adults with Invasive Aspergillosis

  • Barbara D. Alexander,
  • Melissa Johnson,
  • Mark Bresnik,
  • Vamshi Ruthwik Anupindi,
  • Lia Pizzicato,
  • Mitchell DeKoven,
  • Belinda Lovelace and
  • Craig I. Coleman

17 December 2024

Changes to antifungal therapy (AFT) in invasive aspergillosis (IA) may occur due to intolerance, side effects, drug interactions, or lack of response. We describe AFT change patterns in IA patients. This was a US claims data study. IA patients were i...

  • Article
  • Open Access
567 Views
14 Pages

Background and Objectives: Healthcare payment systems face challenges such as fraud and overbilling, which often require costly and resource-intensive detection tools. In response, the utility of simple statistical tests was explored in this study as...

  • Article
  • Open Access
28 Citations
6,213 Views
8 Pages

Healthcare Cost and Utilization before and after Diagnosis of Pseudomonas aeruginosa among Patients with Non-Cystic Fibrosis Bronchiectasis in the U.S.

  • Christopher M. Blanchette,
  • Joshua M. Noone,
  • Glenda Stone,
  • Emily Zacherle,
  • Ripsi P. Patel,
  • Reuben Howden and
  • Douglas Mapel

23 September 2017

Non-cystic fibrosis bronchiectasis (NCFBE) is a rare, chronic lung disease characterized by bronchial inflammation and permanent airway dilation. Chronic infections with P. aeruginosa have been linked to higher morbidity and mortality. To understand...

  • Article
  • Open Access
7 Citations
4,799 Views
12 Pages

Increasing Fruit and Vegetable Variety over Time Is Associated with Lower 15-Year Healthcare Costs: Results from the Australian Longitudinal Study on Women’s Health

  • Jennifer N. Baldwin,
  • Lee M. Ashton,
  • Peta M. Forder,
  • Rebecca L. Haslam,
  • Alexis J. Hure,
  • Deborah J. Loxton,
  • Amanda J. Patterson and
  • Clare E. Collins

18 August 2021

Healthcare costs are lower for adults who consume more vegetables; however, the association between healthcare costs and fruit and vegetable varieties is unclear. Our aim was to investigate the association between (i) baseline fruit and vegetable (F&...

  • Review
  • Open Access
2 Citations
2,849 Views
17 Pages

Real-world data (RWD) has emerged as a crucial component in understanding and improving patient outcomes across various medical conditions, including retinal diseases. Health claims databases, generated from healthcare reimbursement claims, offer a c...

  • Article
  • Open Access
4 Citations
3,988 Views
12 Pages

14 February 2024

Background: The COVID-19 pandemic affected the utilization of healthcare services in many parts of the world. The response to the healthcare burden imposed by the COVID-19 pandemic was associated with ensuring the provision of optimum healthcare serv...

  • Article
  • Open Access
2,524 Views
11 Pages

6 November 2024

The global trend toward self-medication has increased public reliance on over-the-counter treatments and health-related information, contributing to the spread of pseudoscientific claims in healthcare and posing serious public health risks. Pharmacis...

  • Article
  • Open Access
4 Citations
3,912 Views
10 Pages

Requests for Compensation in Cases Involving Patients’ Falls in Healthcare Settings: A Retrospective Analysis

  • Federica Mele,
  • Mirko Leonardelli,
  • Stefano Duma,
  • Carlo Angeletti,
  • Gerardo Cazzato,
  • Carmelo Lupo,
  • Ettore Gorini,
  • Cristoforo Pomara,
  • Alessandro Dell’Erba and
  • Maricla Marrone

Falls are the most frequent adverse events recorded in healthcare facilities. By employing a multifaceted strategy to ensure prevention interventions that are specific to the patient type and environmental risk management, risk factor evaluation may...

  • Article
  • Open Access
17 Citations
3,091 Views
10 Pages

This is an update of our report on COVID-19 among health and social welfare workers in Germany. Workers’ compensation claims for occupational diseases (OD) are recorded in a standardized database of the Statutory Accident Insurance and Prevention in...

  • Editorial
  • Open Access
1 Citations
1,960 Views
4 Pages

Snakebite Clinics and Pathogenesis: From Preclinical to Resource Mapping Studies

  • Manuela B. Pucca,
  • Hui F. Wen,
  • Ana M. Moura-da-Silva and
  • Wuelton M. Monteiro

25 October 2023

Amidst the global healthcare landscape, the menace of snakebite envenoming (SBE) has persisted, silently afflicting millions and annually claiming tens of thousands of lives [...]

  • Article
  • Open Access
4,747 Views
10 Pages

Possible Changes and Trends in Non-COVID-19 Vaccine-Prescribing Patterns before and during COVID-19 Pandemic

  • Shirie van Rooyen,
  • Martie Lubbe,
  • Irma Kotze and
  • Nkengafac Villyen Motaze

Due to the COVID-19 pandemic, many children missed their routine vaccinations globally. There is insufficient evidence on the trends in vaccination coverage in the private healthcare sector in South Africa. This study explored the changes in childhoo...

  • Article
  • Open Access
2,812 Views
24 Pages

A Data-Driven Approach to Defining Risk-Adjusted Coding Specificity Metrics for a Large U.S. Dementia Patient Cohort

  • Kaylla Richardson,
  • Sankari Penumaka,
  • Jaleesa Smoot,
  • Mansi Reddy Panaganti,
  • Indu Radha Chinta,
  • Devi Priya Guduri,
  • Sucharitha Reddy Tiyyagura,
  • John Martin,
  • Michael Korvink and
  • Laura H. Gunn

Medical coding impacts patient care quality, payor reimbursement, and system reliability through the precision of patient information documentation. Inadequate coding specificity can have significant consequences at administrative and patient levels....

  • Article
  • Open Access
1,450 Views
17 Pages

3 February 2025

The Christian message evokes the motif of abundant life for all. It is a summon to take seriously the holistic approach to life that has meaning and that is relational in all its expressions and manifestations. It is on this note that one has to appr...

  • Article
  • Open Access
2 Citations
2,659 Views
14 Pages

Trends in Influenza Vaccination Rates among a Medicaid Population from 2016 to 2021

  • Behzad Naderalvojoud,
  • Nilpa D. Shah,
  • Jane N. Mutanga,
  • Artur Belov,
  • Rebecca Staiger,
  • Jonathan H. Chen,
  • Barbee Whitaker and
  • Tina Hernandez-Boussard

11 November 2023

Seasonal influenza is a leading cause of death in the U.S., causing significant morbidity, mortality, and economic burden. Despite the proven efficacy of vaccinations, rates remain notably low, especially among Medicaid enrollees. Leveraging Medicaid...

  • Article
  • Open Access
1 Citations
4,203 Views
17 Pages

Patterns and Mitigation Strategies for Rejected Claims Among Health Facilities Providing Services for the National Health Insurance Fund in Mwanza, Tanzania

  • Ritha Fulla,
  • Namanya Basinda,
  • Theckla Tupa,
  • Peter Chilipweli,
  • Anthony Kapesa,
  • Eveline T. Konje,
  • Domenica Morona and
  • Stephen E. Mshana

4 February 2025

Background: Rejected medical claims pose a significant challenge for healthcare facilities accredited by Tanzania’s National Health Insurance Fund (NHIF). Despite the NHIF’s role in reducing out-of-pocket costs, claim rejections have been...

  • Article
  • Open Access
3 Citations
3,707 Views
11 Pages

Changes to the payment structure of the United States (U.S.) healthcare system are leading to an increased acuity level of patients receiving short-term skilled nursing facility care. Most skilled nursing facility patients are older, and many have me...

  • Article
  • Open Access
10 Citations
3,799 Views
13 Pages

How Well Did the Healthcare System Respond to the Healthcare Needs of Older People with and without Dementia during the COVID-19 Pandemic? The Perception of Healthcare Providers and Older People from the SI4CARE Project in the ADRION Region

  • Stella Fragkiadaki,
  • Dionysia Kontaxopoulou,
  • Evangelia Stanitsa,
  • Efthalia Angelopoulou,
  • Dimosthenis Pavlou,
  • Darja Šemrov,
  • Simon Colnar,
  • Mitja Lustrek,
  • Bojan Blažica and
  • Inga Vučica
  • + 19 authors

One major challenge during the COVID-19 pandemic was the limited accessibility to healthcare facilities, especially for the older population. The aim of the current study was the exploration of the extent to which the healthcare systems responded to...

  • Article
  • Open Access
6 Citations
3,661 Views
9 Pages

Preventing dementia in elderly individuals is an important public health challenge. While early identification and modification of predictors are crucial, predictors of dementia based on routinely collected healthcare data are not fully understood. W...

  • Review
  • Open Access
1 Citations
2,757 Views
10 Pages

Title: The Impact of Social Media on Public Perception and Litigation in Hernia Surgery Complications. Introduction: Social media significantly impacts public perception of healthcare, leading to increased litigation for complications after hernia su...

  • Review
  • Open Access
34 Citations
11,465 Views
13 Pages

Investigating the Regulatory Process, Safety, Efficacy and Product Transparency for Nutraceuticals in the USA, Europe and Australia

  • Muralikrishna Gangadharan Komala,
  • Ser Gin Ong,
  • Muhammad Uzair Qadri,
  • Lamees M. Elshafie,
  • Carol A. Pollock and
  • Sonia Saad

16 January 2023

Increased numbers of patients with chronic conditions use nutraceuticals or food-based therapeutics. However, to date, there is no global consensus on the regulatory processes for nutraceuticals. With the increased use, issues of quality and safety h...

  • Article
  • Open Access
1 Citations
3,304 Views
12 Pages

This retrospective cohort study described changes in all-cause healthcare resource utilization (HCRU) and associated costs in dementia patients newly diagnosed with psychosis. Dementia and incident psychosis were identified using diagnostic and pharm...

  • Article
  • Open Access
21 Citations
3,955 Views
22 Pages

27 August 2020

The Internet of Things (IoT) has been integrated into legacy healthcare systems for the purpose of improving healthcare processes. As one of the key technologies of IoT, radio frequency identification (RFID) technology has been applied to offer servi...

  • Article
  • Open Access
6 Citations
2,442 Views
15 Pages

29 April 2024

Background and Objective: The aim of this study was to analyze trends in surgical and non-surgical service utilization for common shoulder disorders in Korea from 2010 to 2019. Methods and Materials: This retrospective, cross-sectional, descriptive s...

  • Article
  • Open Access
709 Views
25 Pages

13 October 2025

Medicare fraud poses a substantial challenge to healthcare systems, resulting in significant financial losses and undermining the quality of care provided to legitimate beneficiaries. This study investigates the use of machine learning (ML) to enhanc...

  • Article
  • Open Access
8 Citations
4,434 Views
17 Pages

The Economic Impact of Rectal Cancer: A Population-Based Study in Italy

  • Anna Gigli,
  • Silvia Francisci,
  • Giulia Capodaglio,
  • Daniela Pierannunzio,
  • Sandra Mallone,
  • Andrea Tavilla,
  • Tania Lopez,
  • Manuel Zorzi,
  • Fabrizio Stracci and
  • Susanna Busco
  • + 11 authors

Costs of cancer care are increasing worldwide, and sustainability of cancer burden is critical. In this study, the economic impact of rectal cancer on the Italian healthcare system, measured as public healthcare expenditure related to investigation a...

  • Review
  • Open Access
229 Citations
40,812 Views
19 Pages

Corn Silk (Stigma Maydis) in Healthcare: A Phytochemical and Pharmacological Review

  • Khairunnisa Hasanudin,
  • Puziah Hashim and
  • Shuhaimi Mustafa

13 August 2012

Corn silk (Stigma maydis) is an important herb used traditionally by the Chinese, and Native Americans to treat many diseases. It is also used as traditional medicine in many parts of the world such as Turkey, United States and France. Its potential...

  • Review
  • Open Access
42 Citations
7,043 Views
13 Pages

COVID-19 Associated Mucormycosis: A Systematic Review from Diagnostic Challenges to Management

  • Farah Yasmin,
  • Hala Najeeb,
  • Aisha Naeem,
  • Kartik Dapke,
  • Rachana Phadke,
  • Muhammad Sohaib Asghar,
  • Syed Muhammad Ismail Shah,
  • Domenico De Berardis and
  • Irfan Ullah

22 September 2021

The coronavirus disease 2019 (COVID-19) outbreak has caused significant destruction, claiming over three million lives worldwide. Post SARS-COV-2 invasion, immunosuppression with hyperglycemia and elevated ferritin levels along with steroidal treatme...

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