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Search Results (1,838)

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Keywords = generative AI technology

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16 pages, 529 KB  
Review
Conceptualizing the Impact of AI on Teacher Knowledge and Expertise: A Cognitive Load Perspective
by Irfan Ahmed Rind
Educ. Sci. 2026, 16(1), 57; https://doi.org/10.3390/educsci16010057 (registering DOI) - 1 Jan 2026
Abstract
Artificial intelligence (AI) is increasingly embedded in education through adaptive platforms, intelligent tutoring systems, and generative tools. While these technologies promise efficiency and personalization, they also raise concerns about pedagogical deskilling, reduced teacher autonomy, and ethical risks. This paper conceptualizes the potential impacts [...] Read more.
Artificial intelligence (AI) is increasingly embedded in education through adaptive platforms, intelligent tutoring systems, and generative tools. While these technologies promise efficiency and personalization, they also raise concerns about pedagogical deskilling, reduced teacher autonomy, and ethical risks. This paper conceptualizes the potential impacts of AI on teaching expertise and instructional design through the lens of Cognitive Load Theory (CLT). The aim is to conceptualize how AI may reshape the management of intrinsic, extraneous, and germane cognitive loads. The study proposes that AI may effectively scaffold intrinsic load and reduce extraneous distractions but displace teacher judgment in ways that undermine germane learning and reflective practice. Additionally, opacity, algorithmic bias, and inequities in access may create new forms of cognitive and ethical burden. The conceptualization presented in this paper contributes to scholarship by foregrounding teacher cognition, an underexplored dimension of AI research, conceptualizing the teacher as a cognitive orchestrator who balances human and algorithmic inputs, and integrating ethical and equity considerations into a cognitive framework. Recommendations are provided for teacher education, policy, and AI design, emphasizing the need for pedagogy-driven integration that preserves teacher expertise and supports deep learning. Full article
(This article belongs to the Topic AI Trends in Teacher and Student Training)
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26 pages, 1308 KB  
Article
Faculty Perceptions and Adoption of AI in Higher Education: Insights from Two Lebanese Universities
by Najib Najjar, Melissa Rouphael, Maya El Hajj, Tania Bitar, Pascal Damien and Walid Hleihel
Educ. Sci. 2026, 16(1), 55; https://doi.org/10.3390/educsci16010055 - 31 Dec 2025
Abstract
Artificial intelligence (AI) is increasingly transforming higher education, evolving from simple personalization tools into a wide range of applications that support teaching, learning, and assessment. This study examines how university instructors in Lebanon perceive and adopt AI in their academic practices, drawing on [...] Read more.
Artificial intelligence (AI) is increasingly transforming higher education, evolving from simple personalization tools into a wide range of applications that support teaching, learning, and assessment. This study examines how university instructors in Lebanon perceive and adopt AI in their academic practices, drawing on evidence from two private institutions: Notre Dame University–Louaize (NDU) and the Holy Spirit University of Kaslik (USEK). The study also proposes practical directions for effective institutional implementation. Using a cross-sectional design and convenience sampling, data were collected from 133 faculty members. Although 73.7% of participants reported moderate to high familiarity with AI, their actual classroom use of such tools remained limited. Adoption was primarily centered on chatbots (69.2%) and translation tools (54.9%), while more advanced technologies, such as adaptive learning systems and AI-based tutoring platforms, were seldom utilized (under 7%). Additionally, participants identified efficiency (69.2%), increased student engagement (44.4%), and personalized learning opportunities (42.9%) as the main benefits of AI integration. In contrast, they reported insufficient training (46.6%), restricted access to resources (45.9%), and concerns about the accuracy of AI-generated outputs (29.3%) as major barriers. Moreover, statistical analysis indicated a strong positive relationship between familiarity with AI and frequency of adoption, with no significant differences across gender, age, or academic qualifications. Overall, the results suggest that faculty members in Lebanese higher education currently view AI primarily as a helpful tool for improving efficiency rather than as a transformative pedagogical innovation. To advance integration, higher education institutions should prioritize targeted professional development, ensure equitable access to AI tools, and establish transparent ethical and governance frameworks. Full article
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16 pages, 1390 KB  
Review
Advancing a Hybrid Decision-Making Model in Anesthesiology: Applications of Artificial Intelligence in the Perioperative Setting
by Gilberto Duarte-Medrano, Natalia Nuño-Lámbarri, Daniele Salvatore Paternò, Luigi La Via, Simona Tutino, Guillermo Dominguez-Cherit and Massimiliano Sorbello
Healthcare 2026, 14(1), 97; https://doi.org/10.3390/healthcare14010097 - 31 Dec 2025
Abstract
Artificial intelligence (AI) is rapidly transforming anesthesiology practice across perioperative settings. This review explores the evolution and implementation of hybrid decision-making models that integrate AI capabilities with human clinical expertise. From historical foundations to current applications, we examine how machine learning algorithms, deep [...] Read more.
Artificial intelligence (AI) is rapidly transforming anesthesiology practice across perioperative settings. This review explores the evolution and implementation of hybrid decision-making models that integrate AI capabilities with human clinical expertise. From historical foundations to current applications, we examine how machine learning algorithms, deep learning networks, and big data analytics are enhancing anesthetic care. Key applications include perioperative risk prediction, AI-assisted patient education, automated analysis of clinical records, airway management support, predictive hemodynamic monitoring, closed-loop anesthetic delivery systems, and pain management optimization. In procedural contexts, AI demonstrates promising utility in regional anesthesia through anatomical structure identification and needle navigation, monitoring anesthetic depth via EEG analysis, and improving quality control in endoscopic sedation. Educational applications include intelligent simulators for procedural training and academic productivity tools. Despite significant advances, implementation challenges persist, including algorithmic bias, data security concerns, clinical validation requirements, and ethical considerations regarding AI-generated content. The optimal integration model emphasizes a complementary approach where AI augments rather than replaces clinical judgment—combining computational efficiency with the irreplaceable contextual understanding and ethical reasoning of the anesthesiologist. This hybrid paradigm reinforces the anesthesiologist’s leadership role in perioperative care while enhancing safety, precision, and efficiency through technological innovation. As AI integration advances, continued emphasis on algorithmic transparency, rigorous clinical validation, and human oversight remains essential to ensure that these technologies enhance rather than compromise patient-centered anesthetic care. Full article
(This article belongs to the Special Issue Smart and Digital Health)
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22 pages, 3592 KB  
Article
Empirical Evidence of AI-Enabled Accessibility in Digital Gastronomy: Development and Evaluation of the Receitas +Power Platform
by Paulo Serra, Ângela Oliveira, Filipe Fidalgo, Bruno Serra, Tiago Infante and Luís Baião
Gastronomy 2026, 4(1), 2; https://doi.org/10.3390/gastronomy4010002 - 31 Dec 2025
Abstract
This study explores how artificial intelligence can promote accessibility and inclusiveness in digital culinary environments. Centred on the Receitas +Power platform, the research adopts an exploratory, multidimensional case study design integrating qualitative and quantitative analyses. The investigation addresses three research questions concerning (i) [...] Read more.
This study explores how artificial intelligence can promote accessibility and inclusiveness in digital culinary environments. Centred on the Receitas +Power platform, the research adopts an exploratory, multidimensional case study design integrating qualitative and quantitative analyses. The investigation addresses three research questions concerning (i) user empowerment beyond recommendation systems, (ii) accessibility best practices across disability types, and (iii) the effectiveness of AI-enabled inclusive solutions. The system was developed following user-centred design principles and WCAG 2.2 standards, combining generative AI modules for recipe creation with accessibility features such as voice interaction and adaptive navigation. The evaluation, conducted with 87 participants, employed the System Usability Scale complemented by thematic qualitative feedback. Results indicate excellent usability (M = 80.6), high reliability (Cronbach’s α = 0.798–0.849), and moderate positive correlations between usability and accessibility dimensions (r = 0.45–0.55). Participants highlighted the platform’s personalisation, clarity, and inclusivity, confirming that accessibility enhances rather than restricts user experience. The findings provide empirical evidence that AI-driven adaptability, when grounded in universal design principles, offers an effective and ethically sound pathway toward digital inclusion. Receitas +Power thus advances the field of inclusive digital gastronomy and presents a replicable framework for human–AI co-creation in accessible web technologies. Full article
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33 pages, 2053 KB  
Systematic Review
Generative AI in Art Education: A Systematic Review of Research Trends, Tool Applications, and Outcomes (2019–2025)
by Yihan Jiang, Yujiao Fan and Zifeng Liu
Educ. Sci. 2026, 16(1), 47; https://doi.org/10.3390/educsci16010047 - 30 Dec 2025
Abstract
Generative artificial intelligence (GenAI) tools are transforming art education by enabling instant creation of textual, visual, audio, and multimodal outputs. This systematic review synthesizes research on GenAI applications in art education from January 2019 to August 2025. Following PRISMA 2020 guidelines, 19 peer-reviewed [...] Read more.
Generative artificial intelligence (GenAI) tools are transforming art education by enabling instant creation of textual, visual, audio, and multimodal outputs. This systematic review synthesizes research on GenAI applications in art education from January 2019 to August 2025. Following PRISMA 2020 guidelines, 19 peer-reviewed empirical studies across six databases (Web of Science, ScienceDirect, Springer, Taylor & Francis, Scopus, and ERIC) met inclusion criteria, which required clear pedagogical implementation with students or educators as active participants. Research accelerated from two studies in 2023 to 14 in 2025, with most studies examining higher education and East Asia contexts through mixed methods approaches and grounded in constructivist and cognitive learning theories. Text-to-image generation models (DALL-E, Midjourney, Stable Diffusion) and conversational AI (ChatGPT) were most frequently implemented across creative production, pedagogical scaffolding, and instructional design applications. Findings from this emerging body of research suggest that GenAI has the potential to improve learning achievement, creative thinking, engagement, and cultural understanding when integrated through structured pedagogical frameworks with intentional instructor design. However, these positive outcomes represent early-stage implementation trends in well-resourced contexts rather than broadly generalizable conclusions. Successful integration requires explicit instructional frameworks, clear ethical guidelines for human-AI collaboration, and evolved assessment methods. Full article
(This article belongs to the Special Issue The Impact of Artificial Intelligence on Teaching and Learning)
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26 pages, 373 KB  
Perspective
Hardware Accelerators for Cardiovascular Signal Processing: A System-on-Chip Perspective
by Rami Hariri, Marcian Cirstea, Mahdi Maktab Dar Oghaz, Khaled Benkrid and Oliver Faust
Micromachines 2026, 17(1), 51; https://doi.org/10.3390/mi17010051 - 30 Dec 2025
Abstract
This study presents a comprehensive systematic analysis, investigating hardware accelerators specifically designed for real-time cardiovascular signal processing, focusing mainly on Electrocardiogram (ECG), Photoplethysmogram (PPG), and blood pressure monitoring systems. Cardiovascular Diseases (CVDs) represent the world’s leading cause of morbidity and mortality, creating an [...] Read more.
This study presents a comprehensive systematic analysis, investigating hardware accelerators specifically designed for real-time cardiovascular signal processing, focusing mainly on Electrocardiogram (ECG), Photoplethysmogram (PPG), and blood pressure monitoring systems. Cardiovascular Diseases (CVDs) represent the world’s leading cause of morbidity and mortality, creating an urgent demand for efficient and accurate diagnostic technologies. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we systematically analysed 59 research papers on this topic, published from 2014 to 2024, categorising them into three main categories: signal denoising, feature extraction, and decision support with Machine Learning (ML) or Deep Learning (DL). A comprehensive performance benchmarking across energy efficiency, processing speed, and clinical accuracy demonstrates that hybrid Field Programmable Gate Array (FPGA)-Application Specific Integrated Circuit (ASIC) architectures and specialised Artificial Intelligence (AI) on Edge accelerators represent the most promising solutions for next-generation CVD monitoring systems. The analysis identifies key technological gaps and proposes future research directions focused on developing ultra-low-power, clinically robust, and highly scalable physiological signal processing systems. The findings provide guidance for advancing hardware-accelerated cardiovascular diagnostics toward practical clinical deployment. Full article
(This article belongs to the Special Issue Advances in Field-Programmable Gate Arrays (FPGAs))
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15 pages, 505 KB  
Article
ChatGPT in Health Professions Education: Findings and Implications from a Cross-Sectional Study Among Students in Saudi Arabia
by Muhammad Kamran Rasheed, Fay Alonayzan, Nouf Alresheedi, Reema I. Aljasir, Ibrahim S. Alhomoud and Alian A. Alrasheedy
Int. Med. Educ. 2026, 5(1), 6; https://doi.org/10.3390/ime5010006 - 30 Dec 2025
Viewed by 33
Abstract
The integration of artificial intelligence (AI) tools, such as the chat generative pre-trained transformer (ChatGPT), into health professions education is rapidly accelerating, creating new opportunities for personalized learning and clinical preparation. These tools have demonstrated the potential to enhance learning efficiency and critical [...] Read more.
The integration of artificial intelligence (AI) tools, such as the chat generative pre-trained transformer (ChatGPT), into health professions education is rapidly accelerating, creating new opportunities for personalized learning and clinical preparation. These tools have demonstrated the potential to enhance learning efficiency and critical thinking. However, concerns regarding reliability, academic integrity, and potential overreliance highlight the need to better understand how healthcare students adopt and perceive these technologies in order to guide their effective and responsible integration into educational frameworks. This nationwide, cross-sectional, survey-based study was conducted between February and April 2024 among undergraduate students enrolled in medical, pharmacy, nursing, dental, and allied health programs in Saudi Arabia. An online questionnaire collected data on ChatGPT usage patterns, satisfaction, perceived benefits and risks, and attitudes toward integrating them into the curricula. Among 1044 participants, the prevalence of ChatGPT use was 69.25% (n = 723). Students primarily utilized the tool for content summarization, assignment preparation, and exam-related study. Key motivators included time efficiency and convenience, with improved learning efficiency and reduced study stress identified as major benefits. Conversely, major challenges included subscription costs and difficulties in formulating effective prompts. Furthermore, concerns regarding overreliance and academic misconduct were frequently reported. In conclusion, the adoption of generative AI tools such as ChatGPT among healthcare students in Saudi Arabia was high, driven by its perceived ability to enhance learning efficiency and personalization. To maximize its benefits and minimize risks, institutions should establish clear policies, provide faculty oversight, and integrate AI literacy into the education of health professionals. Full article
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21 pages, 2232 KB  
Article
Effects of Pedagogical Agent-Generated Summaries on Video-Based Learning: Evidence from Eye-Tracking and EEG
by Lei Yuan, Jiyuan Xu and Zehui Zhan
Educ. Sci. 2026, 16(1), 39; https://doi.org/10.3390/educsci16010039 - 29 Dec 2025
Viewed by 109
Abstract
As an emerging learning support technology, large language model-powered pedagogical agents demonstrate significant potential in enhancing video learning effectiveness, yet the underlying cognitive mechanisms remain inadequately elucidated. This study employed a multimodal approach combining EEG and eye-tracking to investigate the effects of AI-generated [...] Read more.
As an emerging learning support technology, large language model-powered pedagogical agents demonstrate significant potential in enhancing video learning effectiveness, yet the underlying cognitive mechanisms remain inadequately elucidated. This study employed a multimodal approach combining EEG and eye-tracking to investigate the effects of AI-generated mind maps and text summaries on learning performance and cognitive processing. Following data screening, 80 valid datasets from education majors were randomly assigned to three groups: mind map summary (PA-MMS, n = 27), text summary (PA-TS, n = 28), and control (NPA, n = 25). Results showed both experimental groups achieved significantly higher post-test scores than controls, with PA-MMS demonstrating the strongest performance (d = 3.78). EEG evidence indicated pedagogical agents reduced Theta activity (decreased working memory load) while PA-MMS enhanced Alpha activity (superior attention control). Eye-tracking revealed differentiated strategies: PA-MMS exhibited networked fixation patterns facilitating integration; PA-TS demonstrated linear scanning. Delayed testing showed PA-MMS achieved the highest retention (96.8%). Correlations confirmed posttest scores negatively correlated with Theta (r = −0.46) and extraneous load (r = −0.61), positively with germane load (r = 0.54). Mind maps simultaneously reduced extraneous load (d = 1.26) while enhancing germane processing (d = 1.15), representing a shift from static scaffolds to AI-mediated generative support. Full article
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14 pages, 319 KB  
Article
AI-Enhanced Perceptual Hashing with Blockchain for Secure and Transparent Digital Copyright Management
by Zhaoxiong Meng, Rukui Zhang, Bin Cao, Meng Zhang, Yajun Li, Huhu Xue and Meimei Yang
Cryptography 2026, 10(1), 2; https://doi.org/10.3390/cryptography10010002 - 29 Dec 2025
Viewed by 95
Abstract
This study presents a novel framework for digital copyright management that integrates AI-enhanced perceptual hashing, blockchain technology, and digital watermarking to address critical challenges in content protection and verification. Traditional watermarking approaches typically employ content-independent metadata and rely on centralized authorities, introducing risks [...] Read more.
This study presents a novel framework for digital copyright management that integrates AI-enhanced perceptual hashing, blockchain technology, and digital watermarking to address critical challenges in content protection and verification. Traditional watermarking approaches typically employ content-independent metadata and rely on centralized authorities, introducing risks of tampering and operational inefficiencies. The proposed system utilizes a pre-trained convolutional neural network (CNN) to generate a robust, content-based perceptual hash value, which serves as an unforgeable watermark intrinsically linked to the image content. This hash is embedded as a QR code in the frequency domain and registered on a blockchain, ensuring tamper-proof timestamping and comprehensive traceability. The blockchain infrastructure further enables verification of multiple watermark sequences, thereby clarifying authorship attribution and modification history. Experimental results demonstrate high robustness against common image modifications, strong discriminative capabilities, and effective watermark recovery, supported by decentralized storage via the InterPlanetary File System (IPFS). The framework provides a transparent, secure, and efficient solution for digital rights management, with potential future enhancements including post-quantum cryptography integration. Full article
(This article belongs to the Special Issue Interdisciplinary Cryptography)
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14 pages, 782 KB  
Article
Novel Low-Power CNFET-GAAFET Based Ternary 9T SRAM Design for Computing-in-Memory Systems
by Adnan A. Patel, Sohan Sai Dasaraju, Yatrik Ashish Shah, Achyuth Gundrapally and Kyuwon Ken Choi
Electronics 2026, 15(1), 137; https://doi.org/10.3390/electronics15010137 - 28 Dec 2025
Viewed by 149
Abstract
The growing demand for energy-efficient memory systems in artificial intelligence (AI) accelerators has intensified research into novel device technologies and computing-in-memory (CIM) architectures. While conventional binary SRAM architectures using CMOS and FinFET devices have been widely explored, ternary-based designs offer potential benefits in [...] Read more.
The growing demand for energy-efficient memory systems in artificial intelligence (AI) accelerators has intensified research into novel device technologies and computing-in-memory (CIM) architectures. While conventional binary SRAM architectures using CMOS and FinFET devices have been widely explored, ternary-based designs offer potential benefits in terms of storage density and computational efficiency. This work presents a low-power analysis of a sense-amplifier embedded (SE) 9-transistor (9T) ternary SRAM architecture implemented using Carbon Nanotube Field-Effect Transistors (CNFETs) and Gate-All-Around Field-Effect Transistors (GAAFETs). The comparative results show a substantial reduction in total power consumption—from 109.2 μW in FinFET to 26.73 μW in GAAFET—and an ultra-low power of only 0.0004 μW in CNFET, representing a 99% reduction compared to FinFET designs. Similarly, the total delay decreases from 0.01108 ns in FinFET to 0.004 ns in GAAFET, while the CNFET design shows a modest delay of 0.017 ns. Overall, GAAFET offers the best trade-off between power and delay, whereas CNFET achieves the lowest power consumption, making it highly suitable for ultra-low-power AI applications. These findings emphasize the superior energy efficiency and scalability potential of CNFET- and GAAFET-based designs over traditional FinFETs, offering a promising pathway toward next-generation ternary CIM-enabled SRAM architectures. Furthermore, fabrication challenges related to CNFET and GAAFET technologies are discussed, providing insights into their practical feasibility for large-scale integration. Full article
(This article belongs to the Special Issue Modern Circuits and Systems Technologies (MOCAST 2024))
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38 pages, 5997 KB  
Article
Blockchain-Enhanced Network Scanning and Monitoring (BENSAM) Framework
by Syed Wasif Abbas Hamdani, Kamran Ali and Zia Muhammad
Blockchains 2026, 4(1), 1; https://doi.org/10.3390/blockchains4010001 - 26 Dec 2025
Viewed by 118
Abstract
In recent years, the convergence of advanced technologies has enabled real-time data access and sharing across diverse devices and networks, significantly amplifying cybersecurity risks. For organizations with digital infrastructures, network security is crucial for mitigating potential cyber-attacks. They establish security policies to protect [...] Read more.
In recent years, the convergence of advanced technologies has enabled real-time data access and sharing across diverse devices and networks, significantly amplifying cybersecurity risks. For organizations with digital infrastructures, network security is crucial for mitigating potential cyber-attacks. They establish security policies to protect systems and data, but employees may intentionally or unintentionally bypass these policies, rendering the network vulnerable to internal and external threats. Detecting these policy violations is challenging, requiring frequent manual system checks for compliance. This paper addresses key challenges in safeguarding digital assets against evolving threats, including rogue access points, man-in-the-middle attacks, denial-of-service (DoS) incidents, unpatched vulnerabilities, and AI-driven automated exploits. We propose a Blockchain-Enhanced Network Scanning and Monitoring (BENSAM) Framework, a multi-layered system that integrates advanced network scanning with a structured database for asset management, policy-driven vulnerability detection, and remediation planning. Key enhancements include device profiling, user activity monitoring, network forensics, intrusion detection capabilities, and multi-format report generation. By incorporating blockchain technology, and leveraging immutable ledgers and smart contracts, the framework ensures tamper-proof audit trails, decentralized verification of policy compliance, and automated real-time responses to violations such as alerts; actual device isolation is performed by external controllers like SDN or NAC systems. The research provides a detailed literature review on blockchain applications in domains like IoT, healthcare, and vehicular networks. A working prototype of the proposed BENSAM framework was developed that demonstrates end-to-end network scanning, device profiling, traffic monitoring, policy enforcement, and blockchain-based immutable logging. This implementation is publicly released and is available on GitHub. It analyzes common network vulnerabilities (e.g., open ports, remote access, and disabled firewalls), attacks (including spoofing, flooding, and DDoS), and outlines policy enforcement methods. Moreover, the framework anticipates emerging challenges from AI-driven attacks such as adversarial evasion, data poisoning, and transformer-based threats, positioning the system for the future integration of adaptive mechanisms to counter these advanced intrusions. This blockchain-enhanced approach streamlines security analysis, extends the framework for AI threat detection with improved accuracy, and reduces administrative overhead by integrating multiple security tools into a cohesive, trustworthy, reliable solution. Full article
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25 pages, 437 KB  
Review
Artificial Intelligence in Routine IVF Practice
by Grzegorz Mrugacz, Aleksandra Mospinek, Małgorzata Jagielska, Dariusz Miszczak, Anna Matosek, Magdalena Ducher-Hanaka, Paweł Gustaw, Klaudia Januszewska, Aleksandra Grzegorczyk and Svetlana Pekar
Biology 2026, 15(1), 42; https://doi.org/10.3390/biology15010042 - 26 Dec 2025
Viewed by 296
Abstract
Background: Artificial Intelligence (AI) has emerged as a transformative tool in in vitro fertilization (IVF) as it has done in other sectors. In IVF, AI offers advancements in embryo selection, treatment personalization, and outcome prediction. It does so by leveraging deep learning [...] Read more.
Background: Artificial Intelligence (AI) has emerged as a transformative tool in in vitro fertilization (IVF) as it has done in other sectors. In IVF, AI offers advancements in embryo selection, treatment personalization, and outcome prediction. It does so by leveraging deep learning and computer vision, as well as AI-driven platforms such as ERICA, iDAScore, and IVY where the goal is to address the limitations of traditional embryo assessment. Key amongst them are the issues of subjectivity, labor intensity, and limited predictive power. Despite rapid technological progress, the integration of AI into routine IVF practice faces key challenges. These are issues related to clinical validation, ethical dilemmas, and workflow adaptation. Rationale/Objectives: This review synthesizes current evidence to evaluate the role of AI in IVF, focusing on six critical dimensions: (1) the evolution of AI from traditional embryology to algorithmic assessment, (2) clinical validation and regulatory considerations, (3) limitations and ethical challenges, (4) pathways for clinical integration, (5) real-world applications and outcomes, and (6) future directions and policy recommendations. The objective is to provide a comprehensive roadmap for the responsible adoption of AI in reproductive medicine. Outcomes: AI demonstrates significant potential to improve the precision and efficiency of IVF. Studies report that AI models can achieve 10 to 25% higher accuracy in predicting embryo viability and implantation potential compared to traditional morphological assessment by embryologists. This enhanced predictive power supports more consistent embryo ranking, facilitates elective single-embryo transfer (eSET) strategies, and is associated with 30 to 50% reductions in embryologist workload per embryo cohort. Early adopters report promising trends. However, large-scale randomized controlled trials have yet to conclusively demonstrate a statistically significant increase in live birth rates per transfer compared to expert embryologist selection. The most immediate and evidenced value of AI lies in hybrid decision-making models. This is where it augments embryologists by providing data-driven, objective support, thereby standardizing workflows and reducing subjectivity. Wider Implications: The sustainable integration of AI into IVF banks on three key aspects: robust evidence generation, interdisciplinary collaboration, and global standardization. To foster these, policymakers ought to establish regulatory frameworks for transparency and bias mitigation. On their part, clinicians need training to interpret AI outputs critically. Ethically, safeguarding patient trust and equity is non-negotiable. Future innovations, mainly AI-enhanced genomics and real-time monitoring, could further personalize care. However, their success depends on addressing current limitations. By balancing innovation with ethical vigilance, AI holds the potential to revolutionize IVF while upholding the highest standards of patient care. Full article
(This article belongs to the Section Medical Biology)
21 pages, 2322 KB  
Article
A Unified AI Architecture for Self-Regulated Learning: Cognitive Modeling, Meta-Learning, and Continual Adaptation
by Ridouane Oubagine, Loubna Laaouina, Adil Jeghal and Hamid Tairi
Algorithms 2026, 19(1), 26; https://doi.org/10.3390/a19010026 - 26 Dec 2025
Viewed by 200
Abstract
The growing need for intelligent educational systems calls for architectures supporting adaptive instruction, while enabling more permanent, long-term personalization and cognitive alignment in the long run. While we have seen progress in adaptive learning technologies at the intersection of Self-Regulated Learning (SRL), Continual [...] Read more.
The growing need for intelligent educational systems calls for architectures supporting adaptive instruction, while enabling more permanent, long-term personalization and cognitive alignment in the long run. While we have seen progress in adaptive learning technologies at the intersection of Self-Regulated Learning (SRL), Continual Learning (CL), and Meta-Learning, these are generally employed in isolation to provide piecemeal solutions. In this paper, we propose CAMEL, a unified architecture for (1) cognitive modelling based on SRL, (2) continual learning functionalities, and (3) meta-learning to provide adaptive, personalized, and cognitively consistent learning environments. CAMEL includes the following components: (1) A Cognitive State Estimator that estimates learner motivation, attention, and persistence from behavioral traces, (2) A Meta-Learning Engine that allows it rapid adaptation through Model-Agnostic Meta-Learning (MAML), (3) A Continual Learning Memory that preserves knowledge across sessions using Elastic Weight Consolidation (EWC) and Replay, (4) A Pedagogical Decision Engine that makes real-time efficient adjustments of instructional strategies, and (5) A closed-loop that continuously reconciles misalignments between pedagogical actions and predicted cognitive states. Experiments conducted on the xAPI-Edu-Data dataset evaluate the system’s few-shot adaptation capability, knowledge retention, cognitive-state prediction accuracy, and knowledge, as well as cognitive responsiveness to the impending questions. It offers competitive performance in learner-state prediction and long-term performance compared to the baselines, and the improvements are consistent across the different baselines. This paper lays the groundwork for next-generation adaptive and cognition-driven AI-based learning systems. Full article
(This article belongs to the Special Issue Emerging Trends in Distributed AI for Smart Environments)
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17 pages, 1188 KB  
Review
Precision Medicine in Prostate Cancer with a Focus on Emerging Therapeutic Strategies
by Ryuta Watanabe, Noriyoshi Miura, Tadahiko Kikugawa and Takashi Saika
Biomedicines 2026, 14(1), 52; https://doi.org/10.3390/biomedicines14010052 - 25 Dec 2025
Viewed by 303
Abstract
Precision medicine has reshaped the clinical management of prostate cancer by integrating comprehensive genomic profiling, biomarker-driven patient stratification, and the development of molecularly targeted therapeutics. Advances in next-generation sequencing have uncovered diverse genomic alterations—including homologous recombination repair defects, MSI-H/MMRd, PTEN loss, BRCA1/BRCA2 mutations, [...] Read more.
Precision medicine has reshaped the clinical management of prostate cancer by integrating comprehensive genomic profiling, biomarker-driven patient stratification, and the development of molecularly targeted therapeutics. Advances in next-generation sequencing have uncovered diverse genomic alterations—including homologous recombination repair defects, MSI-H/MMRd, PTEN loss, BRCA1/BRCA2 mutations, ATM alterations, SPOP mutations, and molecular hallmarks of neuroendocrine differentiation—that now inform individualized treatment decisions. This review synthesizes established clinical evidence with emerging translational insights to provide an updated and forward-looking overview of precision oncology in prostate cancer. Landmark trials of PARP inhibitors and PSMA-targeted radioligand therapy have redefined treatment standards for biomarker-selected patients. Concurrently, efforts to optimize immune checkpoint inhibition, AKT pathway targeting, and rational combinations with androgen receptor pathway inhibitors continue to expand therapeutic possibilities. Rapidly evolving investigational strategies—including bipolar androgen therapy (BAT), immunotherapeutic approaches for CDK12-altered tumors, targeted interventions for SPOP-mutated cancers, and epigenetic modulation such as EZH2 inhibition for neuroendocrine prostate cancer—further illuminate mechanisms of tumor evolution, lineage plasticity, and treatment resistance. Integrating multi-omics technologies, liquid biopsy platforms, and AI-assisted imaging offers new opportunities for dynamic disease monitoring and biology-driven treatment selection. By consolidating current clinical practices with emerging experimental directions, this review provides clinicians and researchers with a comprehensive perspective on the evolving landscape of precision medicine in prostate cancer and highlights future opportunities to improve patient outcomes. Full article
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46 pages, 2542 KB  
Review
Advances in Tuberculous Meningitis: Research, Challenges, and Future Perspectives
by Laura Marinela Ailioaie, Constantin Ailioaie and Gerhard Litscher
Appl. Sci. 2026, 16(1), 232; https://doi.org/10.3390/app16010232 - 25 Dec 2025
Viewed by 208
Abstract
Tuberculous meningitis (TBM) is the most lethal form of tuberculosis (TB), with reported short-term mortality of 20–69% for patients on treatment and five-year deaths exceeding 58%. The World Health Organization has reported a new record of approximately 8.3 million new cases of TB [...] Read more.
Tuberculous meningitis (TBM) is the most lethal form of tuberculosis (TB), with reported short-term mortality of 20–69% for patients on treatment and five-year deaths exceeding 58%. The World Health Organization has reported a new record of approximately 8.3 million new cases of TB diagnosed worldwide, with TBM accounting for 1–5% of these cases in 2024. Heterogeneous clinical manifestations, as well as difficulties in identifying TBM at onset, will delay timely therapy. Drug-resistant TB (DRTB) represents a real threat to public health and is evolving rapidly. Although new drugs have emerged to overcome DRTB, their role in TBM is limited. Our first objective was to update knowledge about the pathogenic mechanisms, clinical manifestations, diagnosis, therapy, and prevention of TBM. Another goal was to highlight advances in nanomedicine and medical imaging in terms of timely diagnosis of TBM and rapid initiation of targeted treatment, including overcoming DRTBM. The last aim was to bring to the attention of infectious disease specialists, neurologists, pediatricians, healthcare professionals, and information technology (IT) specialists the results of clinical trials on TBM published in the last two years. Technological innovation has integrated next-generation sequencing, and IT and artificial intelligence (AI) will develop new applications for precision medicine in TBM and vaccine optimization. Full article
(This article belongs to the Special Issue Tuberculosis—a Millennial Disease in the Age of New Technologies)
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