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33 pages, 1750 KB  
Systematic Review
Quantum and Quantum-Inspired Optimisation in Transport and Logistics: A Systematic Review
by Paloma Liu, Simon Parkinson and Kay Best
Smart Cities 2025, 8(6), 206; https://doi.org/10.3390/smartcities8060206 - 11 Dec 2025
Abstract
Quantum computing offers transformative potential to solve complex optimisation problems in transportation and logistics, particularly those that involve large combinatorial decision spaces such as vehicle routing, traffic control, and supply chain design. Despite theoretical promise and growing empirical interest, its adoption remains limited. [...] Read more.
Quantum computing offers transformative potential to solve complex optimisation problems in transportation and logistics, particularly those that involve large combinatorial decision spaces such as vehicle routing, traffic control, and supply chain design. Despite theoretical promise and growing empirical interest, its adoption remains limited. This systematic literature review synthesises fifteen peer-reviewed studies published between 2015 and 2025, examining the application of quantum and quantum-inspired methods to transport optimisation. The review identifies five key problem domains (vehicle routing, factory scheduling, network design, traffic operations, and energy management) and categorises the quantum techniques used, including quantum annealing, variational circuits, and digital annealers. Although several studies demonstrate performance gains over classical heuristics, most rely on synthetic datasets, lack statistical robustness, and omit critical operational metrics such as energy consumption and queue latency. Four cross-cutting barriers are identified: hardware limitations, data availability, energy inefficiency, and organisational readiness. The review identifies limited real-world deployment, a lack of standardised benchmarks, and scarce cost–benefit evaluations, highlighting key areas where further empirical work is needed. It concludes with a structured research agenda aimed at bridging the gap between laboratory demonstrations and practical implementation, emphasising the need for pilot trials, open datasets, robust experimental protocols, and interdisciplinary collaboration. Full article
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32 pages, 8971 KB  
Systematic Review
Systematic Review of Reinforcement Learning in Process Industries: A Contextual and Taxonomic Approach
by Marco Antonio Paz Ramos and Axel Busboom
Appl. Sci. 2025, 15(24), 12904; https://doi.org/10.3390/app152412904 - 7 Dec 2025
Viewed by 158
Abstract
The process industry (PI) plays a vital role in the global economy and faces mounting pressure to enhance sustainability, operational agility, and resource efficiency amid tightening regulatory and market demands. Although artificial intelligence (AI) has been explored in this domain for decades, its [...] Read more.
The process industry (PI) plays a vital role in the global economy and faces mounting pressure to enhance sustainability, operational agility, and resource efficiency amid tightening regulatory and market demands. Although artificial intelligence (AI) has been explored in this domain for decades, its adoption in industrial practice remains limited. Recently, machine learning (ML) has gained momentum, particularly when integrated with core PI systems such as process control, instrumentation, quality management, and enterprise platforms. Among ML techniques, reinforcement learning (RL) has emerged as a promising approach to tackle complex operational challenges. In contrast to conventional data-driven methods that focus on prediction or classification, RL directly addresses sequential decision making under uncertainty, a defining characteristic of dynamic process operations. Given RL’s growing relevance, this study conducts a systematic literature review to evaluate its current applications in the PI, assess methodological developments, and identify barriers to broader industrial adoption. The review follows the PRISMA methodology, a structured framework for identifying, screening, and selecting relevant publications. This approach ensures alignment with a clearly defined research question and minimizes bias, focusing on studies that demonstrate meaningful industrial applications of RL. The findings reveal that RL is transitioning from a theoretical construct to a practical tool, particularly in the chemical sector and for tasks such as process control and scheduling. Methodological maturity is improving, with algorithm selection increasingly tailored to problem-specific requirements and a trend toward hybrid models that integrate RL with established control strategies. However, most implementations remain confined to simulated environments, underscoring the need for real-world deployment, safety assurances, and improved interpretability. Overall, RL exhibits the potential to serve as a foundational component of next-generation smart manufacturing systems. Full article
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31 pages, 1411 KB  
Article
A Source-to-Source Compiler to Enable Hybrid Scheduling for High-Level Synthesis
by Yuhan She, Yanlong Huang, Jierui Liu, Ray C. C. Cheung and Hong Yan
Electronics 2025, 14(23), 4578; https://doi.org/10.3390/electronics14234578 - 22 Nov 2025
Viewed by 232
Abstract
High-Level Synthesis (HLS) has gained considerable attention for its ability to quickly generate hardware descriptions from untimed specifications. Most state-of-the-art commercial HLS tools employ static scheduling, which excels in compute-intensive applications but struggles with control-dominant designs. While some open-source tools propose dynamic and [...] Read more.
High-Level Synthesis (HLS) has gained considerable attention for its ability to quickly generate hardware descriptions from untimed specifications. Most state-of-the-art commercial HLS tools employ static scheduling, which excels in compute-intensive applications but struggles with control-dominant designs. While some open-source tools propose dynamic and hybrid scheduling techniques to synthesize dataflow-like architectures to improve speed, they lack well-established optimizations from static scheduling like datapath optimization and resource sharing, leading to frequency degradation and area overhead. Moreover, existing hybrid scheduling relies on extra dynamic synthesis support, either by dynamic or static HLS tools, and thereby loses generality. In this work, we propose another solution to achieve hybrid scheduling: a source-to-source compiler that exposes dynamism at the source code level, which reduces both frequency and area overhead while remaining fully compatible with modern static HLS tools without needing extra dynamic synthesis support. Experiments show significant improvements (1.26× speedup) on wall clock time (WCT) compared to VitisHLS and a better area–frequency–latency trade-off compared to dynamic (1.83× WCT speedup and 0.46× area) and hybrid (2.14× WCT speedup and 0.72× area) scheduling-based tools. Full article
(This article belongs to the Special Issue Emerging Applications of FPGAs and Reconfigurable Computing System)
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19 pages, 1742 KB  
Article
Analysis of a Markovian Queueing Model with an Alternating Server and Queue-Length-Based Threshold Control
by Doo Il Choi and Dae-Eun Lim
Mathematics 2025, 13(21), 3555; https://doi.org/10.3390/math13213555 - 6 Nov 2025
Cited by 1 | Viewed by 430
Abstract
This paper analyzes a finite-capacity Markovian queueing system with two customer types, each assigned to a separate buffer, and a single alternating server whose service priority is dynamically controlled by a queue-length-based threshold policy. The arrivals of both customer types follow independent Poisson [...] Read more.
This paper analyzes a finite-capacity Markovian queueing system with two customer types, each assigned to a separate buffer, and a single alternating server whose service priority is dynamically controlled by a queue-length-based threshold policy. The arrivals of both customer types follow independent Poisson processes, and the service times are generally distributed. The server alternates between the two buffers, granting service priority to buffer 1 when its queue length exceeds a specified threshold immediately after service completion; otherwise, buffer 2 receives priority. Once buffer 1 gains priority, it retains it until it becomes empty, with all priority transitions occurring non-preemptively. We develop an embedded Markov chain model to derive the joint queue length distribution at departure epochs and employ supplementary variable techniques to analyze the system performance at arbitrary times. This study provides explicit expressions for key performance measures, including blocking probabilities and average queue lengths, and demonstrates the effectiveness of threshold-based control in balancing service quality between customer classes. Numerical examples illustrate the impact of buffer capacities and threshold settings on system performance and offer practical insights into the design of adaptive scheduling policies in telecommunications, cloud computing, and healthcare systems. Full article
(This article belongs to the Special Issue Advances in Queueing Theory and Applications)
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20 pages, 2972 KB  
Article
Multi-Stage Adaptive Robust Scheduling Framework for Nonlinear Solar-Integrated Transportation Networks
by Puyu He, Jie Jiao, Yuhong Zhang, Yangming Xiao, Zhuhan Long, Hanjing Liu, Zhongfu Tan and Linze Yang
Energies 2025, 18(21), 5841; https://doi.org/10.3390/en18215841 - 5 Nov 2025
Viewed by 323
Abstract
The operation of modern power networks is increasingly exposed to overlapping climate extremes and volatile system conditions, making it essential to adopt scheduling approaches that are resilient as well as economical. In this study, a two-stage stochastic formulation is advanced, where indicators of [...] Read more.
The operation of modern power networks is increasingly exposed to overlapping climate extremes and volatile system conditions, making it essential to adopt scheduling approaches that are resilient as well as economical. In this study, a two-stage stochastic formulation is advanced, where indicators of system adaptability are embedded directly into the optimization process. The objective integrates standard operating expenses—generation, reserve allocation, imports, responsive demand, and fuel resources—with a Conditional Value-at-Risk component that reflects exposure to rare but damaging contingencies, such as extreme heat, severe cold, drought-related hydro scarcity, solar output suppression from wildfire smoke, and supply chain interruptions. Key adaptability dimensions, including storage cycling depth, activation speed of demand response, and resource ramping behavior, are modeled through nonlinear operational constraints. A stylized test system of 30 interconnected areas with a 46 GW demand peak is employed, with more than 2000 climate-informed scenarios compressed to 240 using distribution-preserving reduction techniques. The results indicate that incorporating risk-sensitive policies reduces expected unserved demand by more than 80% during compound disruptions, while the increase in cost remains within 12–15% of baseline planning. Pronounced spatiotemporal differences emerge: evening reserve margins fall below 6% without adaptability provisions, yet risk-adjusted scheduling sustains 10–12% margins. Transmission utilization curves further show that CVaR-based dispatch prevents extreme flows, though modest renewable curtailment arises in outer zones. Moreover, adaptability provisions promote shallower storage cycles, maintain an emergency reserve of 2–3 GWh, and accelerate the mobilization of demand-side response by over 25 min in high-stress cases. These findings confirm that combining stochastic uncertainty modeling with explicit adaptability metrics yields measurable gains in reliability, providing a structured direction for resilient system design under escalating multi-hazard risks. Full article
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33 pages, 3575 KB  
Article
Small-Signal Modeling, Comparative Analysis, and Gain-Scheduled Control of DC–DC Converters in Photovoltaic Applications
by Vipinkumar Shriram Meshram, Fabio Corti, Gabriele Maria Lozito, Luigi Costanzo, Alberto Reatti and Massimo Vitelli
Electronics 2025, 14(21), 4308; https://doi.org/10.3390/electronics14214308 - 31 Oct 2025
Viewed by 493
Abstract
This paper presents an innovative approach to the modeling and dynamic analysis of DC–DC converters in photovoltaic applications. Departing from traditional studies that focus on the transfer function from duty cycle to output voltage, this work investigates the duty cycle to input voltage [...] Read more.
This paper presents an innovative approach to the modeling and dynamic analysis of DC–DC converters in photovoltaic applications. Departing from traditional studies that focus on the transfer function from duty cycle to output voltage, this work investigates the duty cycle to input voltage transfer function, which is critical for accurate dynamic representation of photovoltaic systems. A notable contribution of this study is the integration of the PV panel behavior in the small-signal representation, considering a model-derived differential resistance for various operating points. This technique enhances the model’s accuracy across different operating regions. The paper also validates the effectiveness of this linearization method through small-signal analysis. A comprehensive comparison is conducted among several non-isolated converter topologies such as Boost, Buck–Boost, Ćuk, and SEPIC under both open-loop and closed-loop conditions. To ensure fairness, all converters are designed using a consistent set of constraints, and controllers are tuned to maintain similar phase margins and crossover frequencies across topologies. In addition, a gain-scheduling control strategy is implemented for the Boost converter, where the PI gains are dynamically adapted as a function of the PV operating point. This approach demonstrates superior closed-loop performance compared to a fixed controller tuned only at the maximum power point, further highlighting the benefits of the proposed modeling and control framework. This systematic study therefore provides an objective evaluation of dynamic performance and offers valuable insights into optimal converter architectures and advanced control strategies for photovoltaic systems. Full article
(This article belongs to the Special Issue New Horizons and Recent Advances of Power Electronics)
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35 pages, 1334 KB  
Article
Advanced Optimization of Flowshop Scheduling with Maintenance, Learning and Deteriorating Effects Leveraging Surrogate Modeling Approaches
by Nesrine Touafek, Fatima Benbouzid-Si Tayeb, Asma Ladj and Riyadh Baghdadi
Mathematics 2025, 13(15), 2381; https://doi.org/10.3390/math13152381 - 24 Jul 2025
Viewed by 739
Abstract
Metaheuristics are powerful optimization techniques that are well-suited for addressing complex combinatorial problems across diverse scientific and industrial domains. However, their application to computationally expensive problems remains challenging due to the high cost and significant number of fitness evaluations required during the search [...] Read more.
Metaheuristics are powerful optimization techniques that are well-suited for addressing complex combinatorial problems across diverse scientific and industrial domains. However, their application to computationally expensive problems remains challenging due to the high cost and significant number of fitness evaluations required during the search process. Surrogate modeling has recently emerged as an effective solution to reduce these computational demands by approximating the true, time-intensive fitness function. While surrogate-assisted metaheuristics have gained attention in recent years, their application to complex scheduling problems such as the Permutation Flowshop Scheduling Problem (PFSP) under learning, deterioration, and maintenance effects remains largely unexplored. To the best of our knowledge, this study is the first to investigate the integration of surrogate modeling within the artificial bee colony (ABC) framework specifically tailored to this problem context. We develop and evaluate two distinct strategies for integrating surrogate modeling into the optimization process, leveraging the ABC algorithm. The first strategy uses a Kriging model to dynamically guide the selection of the most effective search operator at each stage of the employed bee phase. The second strategy introduces three variants, each incorporating a Q-learning-based operator in the selection mechanism and a different evolution control mechanism, where the Kriging model is employed to approximate the fitness of generated offspring. Through extensive computational experiments and performance analysis, using Taillard’s well-known standard benchmarks, we assess solution quality, convergence, and the number of exact fitness evaluations, demonstrating that these approaches achieve competitive results. Full article
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16 pages, 2355 KB  
Article
Generalising Stock Detection in Retail Cabinets with Minimal Data Using a DenseNet and Vision Transformer Ensemble
by Babak Rahi, Deniz Sagmanli, Felix Oppong, Direnc Pekaslan and Isaac Triguero
Mach. Learn. Knowl. Extr. 2025, 7(3), 66; https://doi.org/10.3390/make7030066 - 16 Jul 2025
Viewed by 905
Abstract
Generalising deep-learning models to perform well on unseen data domains with minimal retraining remains a significant challenge in computer vision. Even when the target task—such as quantifying the number of elements in an image—stays the same, data quality, shape, or form variations can [...] Read more.
Generalising deep-learning models to perform well on unseen data domains with minimal retraining remains a significant challenge in computer vision. Even when the target task—such as quantifying the number of elements in an image—stays the same, data quality, shape, or form variations can deviate from the training conditions, often necessitating manual intervention. As a real-world industry problem, we aim to automate stock level estimation in retail cabinets. As technology advances, new cabinet models with varying shapes emerge alongside new camera types. This evolving scenario poses a substantial obstacle to deploying long-term, scalable solutions. To surmount the challenge of generalising to new cabinet models and cameras with minimal amounts of sample images, this research introduces a new solution. This paper proposes a novel ensemble model that combines DenseNet-201 and Vision Transformer (ViT-B/8) architectures to achieve generalisation in stock-level classification. The novelty aspect of our solution comes from the fact that we combine a transformer with a DenseNet model in order to capture both the local, hierarchical details and the long-range dependencies within the images, improving generalisation accuracy with less data. Key contributions include (i) a novel DenseNet-201 + ViT-B/8 feature-level fusion, (ii) an adaptation workflow that needs only two images per class, (iii) a balanced layer-unfreezing schedule, (iv) a publicly described domain-shift benchmark, and (v) a 47 pp accuracy gain over four standard few-shot baselines. Our approach leverages fine-tuning techniques to adapt two pre-trained models to the new retail cabinets (i.e., standing or horizontal) and camera types using only two images per class. Experimental results demonstrate that our method achieves high accuracy rates of 91% on new cabinets with the same camera and 89% on new cabinets with different cameras, significantly outperforming standard few-shot learning methods. Full article
(This article belongs to the Section Data)
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17 pages, 984 KB  
Article
Optimizing Wind Turbine Blade Manufacturing Using Single-Minute Exchange of Die and Resource-Constrained Project Scheduling
by Gonca Tuncel, Gokalp Yildiz, Nigar Akcal and Gulsen Korkmaz
Processes 2025, 13(7), 2208; https://doi.org/10.3390/pr13072208 - 10 Jul 2025
Viewed by 1258
Abstract
This paper aims to enhance operational efficiency in the labor-intensive production of composite wind turbine blades, which are critical components of renewable energy systems. The study was conducted at a wind energy facility in Türkiye, integrating the Single-Minute Exchange of Die (SMED) methodology [...] Read more.
This paper aims to enhance operational efficiency in the labor-intensive production of composite wind turbine blades, which are critical components of renewable energy systems. The study was conducted at a wind energy facility in Türkiye, integrating the Single-Minute Exchange of Die (SMED) methodology with a Multi-Mode Resource-Constrained Project Scheduling Problem (MRCPSP) model to reduce production cycle time and optimize labor utilization. An operational time analysis was used to identify and classify non-value-adding activities. SMED principles were then adapted to the fixed-position manufacturing environment, enabling the conversion of internal setup activities into external ones and facilitating task parallelization. These improvements significantly increased productivity and labor efficiency. Subsequently, a scheduling model was developed to optimize the sequence of operations while accounting for activity precedence and resource constraints. As a result, the proposed approach reduced cycle time by 28.6% and increased average labor utilization from 68% to 87%. Scenario analyses confirmed the robustness of the model under varying levels of workforce availability. The findings demonstrate that integrating lean manufacturing techniques with optimization-based scheduling can yield substantial efficiency gains without requiring major capital investment. Moreover, the proposed approach offers practical insights into workforce planning and production scheduling in renewable energy manufacturing environments. Full article
(This article belongs to the Special Issue Design, Control, Modeling and Simulation of Energy Converters)
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30 pages, 4273 KB  
Article
Hybrid Attention-Enhanced Xception and Dynamic Chaotic Whale Optimization for Brain Tumor Diagnosis
by Aliyu Tetengi Ibrahim, Ibrahim Hayatu Hassan, Mohammed Abdullahi, Armand Florentin Donfack Kana, Amina Hassan Abubakar, Mohammed Tukur Mohammed, Lubna A. Gabralla, Mohamad Khoiru Rusydi and Haruna Chiroma
Bioengineering 2025, 12(7), 747; https://doi.org/10.3390/bioengineering12070747 - 9 Jul 2025
Cited by 1 | Viewed by 1123
Abstract
In medical diagnostics, brain tumor classification remains essential, as accurate and efficient models aid medical professionals in early detection and treatment planning. Deep learning methodologies for brain tumor classification have gained popularity due to their potential to deliver prompt and precise diagnostic results. [...] Read more.
In medical diagnostics, brain tumor classification remains essential, as accurate and efficient models aid medical professionals in early detection and treatment planning. Deep learning methodologies for brain tumor classification have gained popularity due to their potential to deliver prompt and precise diagnostic results. This article proposes a novel classification technique that integrates the Xception model with a hybrid attention mechanism and progressive image resizing to enhance performance. The methodology is built on a combination of preprocessing techniques, transfer learning architecture reconstruction, and dynamic fine-tuning strategies. To optimize key hyper-parameters, this study employed the Dynamic Chaotic Whale Optimization Algorithm. Additionally, we developed a novel learning rate scheduler that dynamically adjusts the learning rate based on image size at each training phase, improving training efficiency and model adaptability. Batch sizes and layer freezing methods were also adjusted according to image size. We constructed an ensemble approach by preserving models trained on different image sizes and merging their results using weighted averaging, bagging, boosting, stacking, blending, and voting techniques. Our proposed method was evaluated on benchmark datasets achieving remarkable accuracies of 99.67%, 99.09%, and 99.67% compared to the classical algorithms. Full article
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32 pages, 1107 KB  
Review
Advanced Planning Systems in Production Planning Control: An Ethical and Sustainable Perspective in Fashion Sector
by Martina De Giovanni, Mariangela Lazoi, Romeo Bandinelli and Virginia Fani
Appl. Sci. 2025, 15(13), 7589; https://doi.org/10.3390/app15137589 - 7 Jul 2025
Viewed by 2546
Abstract
In the shift toward sustainable and resource-efficient manufacturing, Artificial Intelligence (AI) is playing a transformative role in overcoming the limitations of traditional production scheduling methods. This study, based on a Systematic Literature Review (SLR), explores how AI techniques enhance Advanced Planning and Scheduling [...] Read more.
In the shift toward sustainable and resource-efficient manufacturing, Artificial Intelligence (AI) is playing a transformative role in overcoming the limitations of traditional production scheduling methods. This study, based on a Systematic Literature Review (SLR), explores how AI techniques enhance Advanced Planning and Scheduling (APS) systems, particularly under finite-capacity constraints. Traditional scheduling models often overlook real-time resource limitations, leading to inefficiencies in complex and dynamic production environments. AI, with its capabilities in data fusion, pattern recognition, and adaptive learning, enables the development of intelligent, flexible scheduling solutions. The integration of metaheuristic algorithms—especially Ant Colony Optimization (ACO) and hybrid models like GA-ACO—further improves optimization performance by offering high-quality, near-optimal solutions without requiring extensive structural modeling. These AI-powered APS systems enhance scheduling accuracy, reduce lead times, improve resource utilization, and enable the proactive identification of production bottlenecks. Especially relevant in high-variability sectors like fashion, these approaches support Industry 5.0 goals by enabling agile, sustainable, and human-centered manufacturing systems. The findings have been highlighted in a structured framework for AI-based APS systems supported by metaheuristics that compares the Industry 4.0 and Industry 5.0 perspectives. The study offers valuable implications for both academia and industry: academics can gain a synthesized understanding of emerging trends, while practitioners are provided with actionable insights for deploying intelligent planning systems that align with sustainability goals and operational efficiency in modern supply chains. Full article
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26 pages, 8994 KB  
Article
Output Feedback Fuzzy Gain Scheduling for MIMO Systems Applied to Flexible Aircraft Control
by Guilherme C. Barbosa and Flávio J. Silvestre
Aerospace 2025, 12(6), 557; https://doi.org/10.3390/aerospace12060557 - 18 Jun 2025
Viewed by 565
Abstract
Previous works by our group evidenced stability problems associated with flight control law design for flexible aircraft regarding gain scheduling. This paper proposes an output feedback fuzzy-based gain scheduling approach to adequate closed-loop response in a broader range of the flight envelope. This [...] Read more.
Previous works by our group evidenced stability problems associated with flight control law design for flexible aircraft regarding gain scheduling. This paper proposes an output feedback fuzzy-based gain scheduling approach to adequate closed-loop response in a broader range of the flight envelope. This method applies a variation of the controller gains based on the membership function design for all the varying parameters, such as dynamic pressure. It aims for performance improvement while enforcing global stability gain scheduling. The technique was demonstrated for the flexible ITA X-HALE aircraft nonlinear model and compared to the classical interpolation-based gain scheduling technique. The results revealed that fuzzy-based gain scheduling can effectively handle high-order systems while ensuring global system stability, leading to an overall improvement in performance. Full article
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30 pages, 3046 KB  
Review
A Survey of Advancements in Scheduling Techniques for Efficient Deep Learning Computations on GPUs
by Rupinder Kaur, Arghavan Asad, Seham Al Abdul Wahid and Farah Mohammadi
Electronics 2025, 14(5), 1048; https://doi.org/10.3390/electronics14051048 - 6 Mar 2025
Cited by 3 | Viewed by 8755
Abstract
This comprehensive survey explores recent advancements in scheduling techniques for efficient deep learning computations on GPUs. The article highlights challenges related to parallel thread execution, resource utilization, and memory latency in GPUs, which can lead to suboptimal performance. The surveyed research focuses on [...] Read more.
This comprehensive survey explores recent advancements in scheduling techniques for efficient deep learning computations on GPUs. The article highlights challenges related to parallel thread execution, resource utilization, and memory latency in GPUs, which can lead to suboptimal performance. The surveyed research focuses on novel scheduling policies to improve memory latency tolerance, exploit parallelism, and enhance GPU resource utilization. Additionally, it explores the integration of prefetching mechanisms, fine-grained warp scheduling, and warp switching strategies to optimize deep learning computations. These techniques demonstrate significant improvements in throughput, memory bank parallelism, and latency reduction. The insights gained from this survey can guide researchers, system designers, and practitioners in developing more efficient and powerful deep learning systems on GPUs. Furthermore, potential future research directions include advanced scheduling techniques, energy efficiency considerations, and the integration of emerging computing technologies. Through continuous advancement in scheduling techniques, the full potential of GPUs can be unlocked for a wide range of applications and domains, including GPU-accelerated deep learning, task scheduling, resource management, memory optimization, and more. Full article
(This article belongs to the Special Issue Emerging Applications of FPGAs and Reconfigurable Computing System)
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25 pages, 1751 KB  
Review
Strategies to Overcome Intrinsic and Acquired Resistance to Chemoradiotherapy in Head and Neck Cancer
by Tycho de Bakker, Anouk Maes, Tatiana Dragan, Philippe Martinive, Sébastien Penninckx and Dirk Van Gestel
Cells 2025, 14(1), 18; https://doi.org/10.3390/cells14010018 - 27 Dec 2024
Cited by 3 | Viewed by 2667
Abstract
Definitive chemoradiotherapy (CRT) is a cornerstone of treatment for locoregionally advanced head and neck cancer (HNC). Research is ongoing on how to improve the tumor response to treatment and limit normal tissue toxicity. A major limitation in that regard is the growing occurrence [...] Read more.
Definitive chemoradiotherapy (CRT) is a cornerstone of treatment for locoregionally advanced head and neck cancer (HNC). Research is ongoing on how to improve the tumor response to treatment and limit normal tissue toxicity. A major limitation in that regard is the growing occurrence of intrinsic or acquired treatment resistance in advanced cases. In this review, we will discuss how overexpression of efflux pumps, perturbation of apoptosis-related factors, increased expression of antioxidants, glucose metabolism, metallotheionein expression, increased DNA repair, cancer stem cells, epithelial-mesenchymal transition, non-coding RNA and the tumour microenvironment contribute towards resistance of HNC to chemotherapy and/or radiotherapy. These mechanisms have been investigated for years and been exploited for therapeutic gain in resistant patients, paving the way to the development of new promising drugs. Since in vitro studies on resistance requires a suitable model, we will also summarize published techniques and treatment schedules that have been shown to generate acquired resistance to chemo- and/or radiotherapy that most closely mimics the clinical scenario. Full article
(This article belongs to the Section Cellular Metabolism)
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12 pages, 765 KB  
Article
Enhancing Outcomes and Efficiency in Large Epidermal Cyst Management: Quality Improvement Approach in Primary Care
by Waseem Jerjes, Pratik Ramkumar and Yousuf Yaqub
Clin. Pract. 2024, 14(6), 2433-2444; https://doi.org/10.3390/clinpract14060190 - 12 Nov 2024
Viewed by 1450
Abstract
Background: Epidermal cysts are common benign lesions encountered in primary care, especially in minor surgery clinics. The management of large epidermal cysts (>5 cm in diameter) poses significant challenges, including surgical intervention requirements, potential for complications, and impacts on patient care and clinic [...] Read more.
Background: Epidermal cysts are common benign lesions encountered in primary care, especially in minor surgery clinics. The management of large epidermal cysts (>5 cm in diameter) poses significant challenges, including surgical intervention requirements, potential for complications, and impacts on patient care and clinic workflow. The prevalence of these cysts underlines the need for optimised management strategies that are essential for enhancing patient outcomes and clinic efficiency. This quality improvement initiative sought to better manage large epidermal cysts in primary care settings. Patients and methods: The initiative utilised the Plan-Do-Study-Act (PDSA) cycle over three distinct phases, with an emphasis on improving surgical techniques and postoperative care, optimising clinic workflow, and enhancing patient education and involvement. Over the course of this eighteen-month study, 100 patients who required surgical excision of large epidermal cysts were included. The interventions focused on standardising surgical protocols, implementing a new scheduling system, and developing comprehensive educational materials for patients. Results: The programme contributed to major efficiency gains for surgeries: the average operative time was reduced from 45 min to 30. The postoperative complication rate decreased dramatically while patient and clinician satisfaction went up, as did clinic throughput. With patient education enhancements, follow-up adherence rose to 92% while the postoperative complication rate declined from 18% to 9% with the overall approach to patient engagement. Conclusions: The successful application of the PDSA cycles in this work demonstrates that quality improvement methodologies have a potential role in optimising management for large epidermal cysts in primary care settings. Developed interventions can therefore be put into routine care that will indeed improve patient outcome, clinician experience, and operational efficiency in minor surgery clinics. Full article
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