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Search Results (220)

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22 pages, 38941 KB  
Article
Fusion Framework of Remote Sensing and Electromagnetic Scattering Features of Drones for Monitoring Freighters
by Zeyang Zhou and Jun Huang
Drones 2026, 10(1), 74; https://doi.org/10.3390/drones10010074 - 22 Jan 2026
Viewed by 94
Abstract
Certain types of unmanned aerial vehicles (UAVs) represent convenient platforms for remote sensing observation as well as low-altitude targets that are themselves monitored by other devices. In order to study remote sensing grayscale and radar cross-section (RCS) in an example drone, we present [...] Read more.
Certain types of unmanned aerial vehicles (UAVs) represent convenient platforms for remote sensing observation as well as low-altitude targets that are themselves monitored by other devices. In order to study remote sensing grayscale and radar cross-section (RCS) in an example drone, we present a fusion framework based on remote sensing imaging and electromagnetic scattering calculations. The results indicate that the quadcopter drone shows weak visual effects in remote sensing grayscale images while exhibiting strong dynamic electromagnetic scattering features that can exceed 29.6815 dBm2 fluctuations. The average and peak RCS of the example UAV are higher than those of the quadcopter in the given cases. The example freighter exhibits the most intuitive grayscale features and the largest RCS mean under the given observation conditions, with a peak of 51.6186 dBm2. Compared to the UAV, the small boat with a sharp bow design has similar dimensions while exhibiting lower RCS features and intuitive remote sensing grayscale. Under cross-scale conditions, grayscale imaging is beneficial for monitoring UAVs, freighters, and other nearby boats. Dynamic RCS features and grayscale local magnification are suitable for locating and recognizing drones. The established approach is effective in learning remote sensing grayscale and electromagnetic scattering features of drones used for observing freighters. Full article
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24 pages, 15635 KB  
Article
Effect of Post-Printing Methods on the Microstructure and Mechanical Properties of Ti6Al4V Titanium Alloy Samples Fabricated Using Laser Powder Bed Fusion
by Krzysztof Żaba, Stanislav Rusz, Alicja Haslik-Sopata, Łukasz Kuczek, Ilona Różycka, Maciej Balcerzak and Tomasz Trzepieciński
Materials 2026, 19(2), 401; https://doi.org/10.3390/ma19020401 - 19 Jan 2026
Viewed by 215
Abstract
Laser powder bead fusion (LPBF) allows for the fabrication of highly accurate components from metal powders, which is difficult to achieve using traditional methods. LPBF-produced components can be characterized by their porosity and unfavorable microstructure, making further processing difficult. Therefore, appropriate post-printing methods [...] Read more.
Laser powder bead fusion (LPBF) allows for the fabrication of highly accurate components from metal powders, which is difficult to achieve using traditional methods. LPBF-produced components can be characterized by their porosity and unfavorable microstructure, making further processing difficult. Therefore, appropriate post-printing methods are crucial, as they reduce porosity, reduce residual stresses, and stabilize the microstructure. The aim of this paper was to determine the effect of post-printing methods on the microhardness and microstructure of Ti6Al4V titanium alloy samples fabricated using the LPBF process in different orientations. Hot isostatic pressing (HIP) at various temperatures (910 °C, 1150 °C, 1250 °C), annealing at 1020 °C, and twist channel angular pressing using a 90° channel ending with a helical exit were considered postprocessing methods for LPBF-produced samples. Printing orientation significantly determined the effectiveness of HIP and the heat treatment processes. Higher microhardness was observed on the cross-section oriented perpendicular to the 3D printing direction. Annealing under appropriately selected conditions favors the precipitation of fine particles of the α phase in the β phase, leading to a strengthening effect by precipitation. Based on the microhardness measurements, clear differences were observed in the mean values, statistical ranges, and result distributions depending on the printing plane, HIP process parameters, and the use of an additional heat treatment. The HIP process leads to a more pronounced homogenization of microstructure and defect reduction, with the morphology of the microstructure and microhardness distribution dependent on the HIP process temperature. Full article
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26 pages, 3099 KB  
Article
Bread and Bakery Products: Cultural Importance, Consumption, Purchase Patterns, and Household Waste During Ramadan in Constantine, Algeria
by Fatima Zohra Becila, Linda Dridi, Abdallah Bouasla, Rania Boussekine and Meriem Bencharif
Sustainability 2026, 18(1), 543; https://doi.org/10.3390/su18010543 - 5 Jan 2026
Viewed by 362
Abstract
Household bread and bakery product waste constitutes a growing issue in Algeria, with significant economic, environmental, and socio-cultural implications. This research is situated within the framework of sustainable food systems and responds to recent transformations in domestic food practices, driven by increased female [...] Read more.
Household bread and bakery product waste constitutes a growing issue in Algeria, with significant economic, environmental, and socio-cultural implications. This research is situated within the framework of sustainable food systems and responds to recent transformations in domestic food practices, driven by increased female labor force participation, time constraints, and the widespread availability of industrial bread, which have reshaped household food management and traditional home bread-making practices. The study aims to (1) review traditional Algerian breads, emphasizing their culinary, nutritional, and cultural significance; (2) examine household behaviors during the month of Ramadan in the city of Constantine, focusing on patterns of consumption, purchasing, waste generation, and strategies for reusing leftovers; and (3) assess the economic implications of these practices using the FUSIONS methodology and explore their contribution to household-level food sustainability. Methodologically, a cross-sectional exploratory survey was conducted among 100 married women, the majority of whom were middle-aged (62%; range: 27–71 years; mean age: 52.0 ± 10.21), well-educated (59% with a university degree), economically active (68%), and living in medium-sized households (63%). The findings reveal pronounced contrasts across bread categories. Industrial breads, particularly baguettes, are characterized by high daily purchase frequencies (4.16 ± 1.31 units/day) and the highest waste rates (12.67%), largely attributable to over-purchasing (92%) and low perceived value associated with subsidized prices, with convenience (100%) remaining the primary factor explaining their dominance. In contrast, traditional breads exhibit minimal waste levels (1.63%) despite frequent purchase (3.85 ± 0.70 loaves/day), reflecting more conscious food management shaped by strong cultural attachment, higher perceived value, and dietary preferences (100%). Modern bakery products, along with confections and pastries, the latter representing of 58% of total household food purchases, comprise a substantial share of food expenditure during Ramadan (2.16 ± 0.46 loaves/day and 12.07 and 7.28 ± 2.50 units/day, respectively), while generating relatively low levels of food waste (5.69%, 4.19%, and 0%, respectively). This suggests that higher prices and symbolic value encourage more careful purchasing behaviors and conscious consumption. Freezing leftovers (63%) emerges as the most commonly adopted waste-reduction strategy. Overall, this work provides original quantitative evidence at the household level on bread and bakery product waste in Algeria. It highlights the key socio-economic, cultural, and behavioral drivers underlying waste generation and proposes actionable recommendations to promote more sustainable food practices, in line with the United Nations Sustainable Development Goal 12 on responsible consumption and production. Full article
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9 pages, 214 KB  
Article
Orthoptic Treatment After Strabismus Surgery in Child Intermittent Divergent Strabismus
by Pedro Lino, Pedro Vargues de Aguiar and João Paulo Cunha
Children 2026, 13(1), 70; https://doi.org/10.3390/children13010070 - 1 Jan 2026
Viewed by 227
Abstract
Purpose: To evaluate short-term motor and sensory–motor outcomes following postoperative OT in children with IXT after strabismus surgery. Methods: This prospective before–after observational study included children with IXT who underwent bilateral lateral rectus recession and were referred for postoperative OT based on predefined [...] Read more.
Purpose: To evaluate short-term motor and sensory–motor outcomes following postoperative OT in children with IXT after strabismus surgery. Methods: This prospective before–after observational study included children with IXT who underwent bilateral lateral rectus recession and were referred for postoperative OT based on predefined clinical criteria. A structured 12-week OTplan was initiated approximately six months after surgery. Outcome measures included angle of deviation (prism diopters, PD), near point of convergence (cm), positive fusional vergence amplitudes (PD), and convergence amplitudes at distance and near (PD). Pre- and post-therapy changes were analysed using paired-samples t-tests with effect sizes calculated using Cohen’s d. Final postoperative alignment was additionally compared cross-sectionally between children who underwent OT and those managed without OT. Results: Eighty-eight children had complete paired motor and sensory–motor data and were included in the analyses. Changes in static ocular alignment were small, with mean residual deviation improving from −7.02 ± 6.91 PD to −5.22 ± 6.60 PD after OT (mean change +1.80 PD; p < 0.01; d ≈ 0.30). No significant difference in final postoperative alignment was observed between the OT and non-OT groups (p = 0.827). In contrast, marked improvements were observed in sensory–motor outcomes. Positive fusional vergence amplitude increased from 7.30 ± 8.33 PD to 22.19 ± 9.26 PD (p < 0.001; d ≈ 1.5). Distance convergence amplitude improved from 7.30 ± 8.33 PD to 22.19 ± 9.26 PD, and near convergence amplitude from 10.95 ± 12.50 PD to 33.29 ± 13.89 PD (both p < 0.001; d ≈ 1.5). Near point of convergence showed a modest but significant improvement. Conclusions: Postoperative OT was associated with substantial short-term improvements in sensory–motor function, particularly fusional and convergence capacities, while changes in static ocular alignment were small and of limited clinical relevance. These findings support the role of OT as a functional adjunct to surgery, aimed at enhancing binocular control and postoperative sensory–motor stability in children with IXT. Full article
(This article belongs to the Special Issue Visual Deficits and Eye Care in Children: 2nd Edition)
29 pages, 13647 KB  
Article
Research on Intelligent Wood Species Identification Method Based on Multimodal Texture-Dominated Features and Deep Learning Fusion
by Yuxiang Huang, Tianqi Zhu, Zhihong Liang, Hongxu Li, Mingming Qin, Ruicheng Niu, Yuanyuan Ma, Qi Feng and Mingbo Chen
Plants 2026, 15(1), 108; https://doi.org/10.3390/plants15010108 - 30 Dec 2025
Viewed by 312
Abstract
Aimed at the problems of traditional wood species identification relying on manual experience, slow identification speed, and insufficient robustness, this study takes hyperspectral images of cross-sections of 10 typical wood species commonly found in Puer, Yunnan, China, as the research object. It comprehensively [...] Read more.
Aimed at the problems of traditional wood species identification relying on manual experience, slow identification speed, and insufficient robustness, this study takes hyperspectral images of cross-sections of 10 typical wood species commonly found in Puer, Yunnan, China, as the research object. It comprehensively applies various spectral and texture feature extraction technologies and proposes an intelligent wood species identification method based on the fusion of multimodal texture-dominated features and deep learning. Firstly, an SOC710-VP hyperspectral imager is used to collect hyperspectral data under standard laboratory lighting conditions, and a hyperspectral database of wood cross-sections is constructed through reflectance calibration. Secondly, in the spectral space construction stage, a comprehensive similarity matrix is built based on four types of spectral similarity indicators. Representative bands are selected using two Max–Min strategies: partitioned quota and coverage awareness. Multi-scale wavelet fusion is performed to generate high-resolution fused images and extract interest point features. Thirdly, in the texture space construction stage, three types of texture feature matrices are generated based on the PCA first principal component map, and interest point features are extracted. Fourthly, in the complementary collaborative learning stage, the ST-former model is constructed. The weights of the trained SpectralFormer++ and TextureFormer are imported, and only the fusion weights are optimized and learned to realize category-adaptive spectral–texture feature fusion. Experimental results show that the overall classification accuracy of the proposed joint model reaches 90.27%, which is about 8% higher than that of single-modal models on average. Full article
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9 pages, 1725 KB  
Communication
Percentage of Gutta-Percha-Filled Areas in Canals Obturated by Two Different Core Techniques with Endodontic Bioceramics Sealer
by Antonio Libonati, Danilo Marroni, Giulio Barbalace, Giulia Campanella and Vincenzo Campanella
Materials 2026, 19(1), 37; https://doi.org/10.3390/ma19010037 - 21 Dec 2025
Viewed by 367
Abstract
The aim of this preliminary study was to compare two core-carrier obturation techniques—GuttaFusion (GF) and SoftCore (SC)—used in combination with a bioceramic sealer (NeoSealer Flo), and to evaluate their ability to fill simulated root canals. Eight standardized resin models of maxillary first molars [...] Read more.
The aim of this preliminary study was to compare two core-carrier obturation techniques—GuttaFusion (GF) and SoftCore (SC)—used in combination with a bioceramic sealer (NeoSealer Flo), and to evaluate their ability to fill simulated root canals. Eight standardized resin models of maxillary first molars were used, and only the P and DV canals of each model were obturated. Cross-sections were obtained at 1 mm and 3 mm from the apex, and the percentage areas occupied by gutta-percha (PGFA), sealer (PSFA), and voids (VA) were measured. This study provides novel comparative data on the performance of these two carrier-based techniques when used with a bioceramic sealer. GF showed higher PGFA and lower PSFA compared with SC at 1 mm from the apex, while SC presented slightly higher VA. At 3 mm, PGFA increased for both techniques. Descriptive statistics (means and percentage values) were calculated; no inferential statistical analysis was performed due to the preliminary nature of the study and the limited sample. Full article
(This article belongs to the Special Issue Development and Research of New Dental Materials)
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14 pages, 1989 KB  
Article
A Generic Neutron Analytical Spectrum and Soft-Error Rate for Nuclear Fusion Studies
by Jean-Luc Autran, Daniela Munteanu and Soilihi Moindjie
Electronics 2026, 15(1), 11; https://doi.org/10.3390/electronics15010011 - 19 Dec 2025
Viewed by 264
Abstract
We present an analytical model for the lethargic neutron spectrum (ϕu(E), i.e., per unit of u=ln(E)), which is specifically suited to nuclear fusion environments. The spectrum is represented as the [...] Read more.
We present an analytical model for the lethargic neutron spectrum (ϕu(E), i.e., per unit of u=ln(E)), which is specifically suited to nuclear fusion environments. The spectrum is represented as the sum of three components: (i) a stretched Maxwellian thermal component, (ii) a windowed power-law epithermal plateau and (iii) a log-normal high-energy peak. While being simple and concise, this model allows for accurate fitting to experimental data or transport calculation results, as well as easy extrapolation for different operating conditions. We present the physical basis of the model and provide guidelines for adjusting it. We also demonstrate how it can accurately reproduce neutron spectra from experiments or Monte Carlo simulations that are representative of various nuclear fusion environments. Finally, we use this model to estimate the soft-error rate (SER) for circuits operating in fusion environments, considering, in addition, analytical forms for the single-event neutron cross-section of the circuit in the thermal and high-energy domains to derive analytical or semi-analytical expressions of the SER. Full article
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16 pages, 5757 KB  
Article
Assessment of the Influence of Specimen Size on the Performance of CLF-1 Steel Based on the GTN Model
by Xiang Ruan, Zhanze Shi, Bintao Yu, Bing Bai, Xinfu He, Changyi Zhang and Wen Yang
Metals 2026, 16(1), 1; https://doi.org/10.3390/met16010001 - 19 Dec 2025
Viewed by 252
Abstract
Irradiation embrittlement occurs in the cladding materials of fusion reactors during irradiation. Determining the ductile–brittle transition temperature via Charpy impact testing is the primary method for evaluating irradiation embrittlement. Standard-sized V-shaped Charpy impact specimens (CVN) are too large in size and have high [...] Read more.
Irradiation embrittlement occurs in the cladding materials of fusion reactors during irradiation. Determining the ductile–brittle transition temperature via Charpy impact testing is the primary method for evaluating irradiation embrittlement. Standard-sized V-shaped Charpy impact specimens (CVN) are too large in size and have high induced radioactivity. Small-sized specimens (KLST) can solve these problems, but the performance data measured from small-sized specimens are different from those of standard specimens. In other words, there is a size effect in impact performance. The notch size and hammer impact speed of KLST specimens are different from those of CVN specimens. The influence of these factors on impact performance requires further study. In response to these issues, on the basis of the previous experiments conducted by the research group, GTN damage models of CVN specimens and KLST specimens are constructed using the inverse operation method. Numerical simulation of the impact on the upper platform area is carried out for KLST specimens and variable-sized KLST specimens. Compared with the test results, the numerical simulation results are in good agreement, verifying the accuracy and reliability of the model. The results show that the notch angle and radius have little influence on the plastic zone. The cross-sectional area of the notch has a significant impact on the plastic zone. The impact velocity within the range of 3.8 m/s to 5.24 m/s affects the impact response process, but does not affect the load–displacement curve, the length of the non-plastic deformation zone, or the volume of the plastic zone. Full article
(This article belongs to the Special Issue Fracture Mechanics and Failure Analysis of Metallic Materials)
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14 pages, 788 KB  
Perspective
Intravascular Imaging-Guided Percutaneous Coronary Intervention: Transforming Precision and Outcomes in Contemporary Practice
by Malik Alqawasmi and James C. Blankenship
J. Clin. Med. 2025, 14(24), 8883; https://doi.org/10.3390/jcm14248883 - 16 Dec 2025
Viewed by 838
Abstract
Percutaneous coronary intervention (PCI) has evolved significantly over the past two decades, yet challenges in achieving optimal stent deployment and long-term outcomes persist, particularly in complex coronary anatomy. Intravascular imaging (IVI) modalities such as intravascular ultrasound (IVUS), optical coherence tomography (OCT), and near-infrared [...] Read more.
Percutaneous coronary intervention (PCI) has evolved significantly over the past two decades, yet challenges in achieving optimal stent deployment and long-term outcomes persist, particularly in complex coronary anatomy. Intravascular imaging (IVI) modalities such as intravascular ultrasound (IVUS), optical coherence tomography (OCT), and near-infrared spectroscopy (NIRS) have transformed the precision of PCI by providing detailed cross-sectional visualization of vessel architecture, plaque morphology, and stent apposition. Compared to angiography-guided PCI, imaging-guided PCI enables more accurate lesion assessment, appropriate stent sizing, and detection of suboptimal results including under-expansion, malapposition, and edge dissections, factors strongly linked to restenosis and stent thrombosis. Large-scale randomized trials (e.g., ULTIMATE, ILUMIEN) and meta-analyses have demonstrated that imaging-guided PCI reduces major adverse cardiovascular events (MACE) and improves long-term stent patency, particularly in left main, bifurcation, and calcified lesions. Despite these benefits, adoption remains variable due to cost, procedural complexity, and training gaps. Emerging advances, including artificial intelligence-enhanced imaging, hybrid devices, and fusion of imaging with physiologic assessments, promise to integrate imaging more seamlessly into routine practice. This review summarizes current evidence, practical applications, and future directions of IVI-guided PCI, underscoring its growing role in contemporary interventional cardiology and its potential to personalize and optimize coronary revascularization strategies. Full article
(This article belongs to the Section Cardiology)
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14 pages, 726 KB  
Brief Report
Guiding Antibiotic Therapy with Machine Learning: Real-World Applications of a CDSS in Bacteremia Management
by Juan Carlos Gómez de la Torre, Ari Frenkel, Carlos Chavez-Lencinas, Alicia Rendon, Yoshie Higuchi, Jose M. Vela-Ruiz, Jacob Calpey, Ryan Beaton, Isaac Elijah, Inbal Shachar, Everett Kim, Sofia Valencia Osorio, Jason James Lee, Gabrielle Grogan, Jessica Siegel, Stephanie Allman and Miguel Hueda-Zavaleta
Life 2025, 15(11), 1756; https://doi.org/10.3390/life15111756 - 15 Nov 2025
Viewed by 661
Abstract
Bacteremia is a life-threatening condition contributing significantly to sepsis-related mortality worldwide. With delayed appropriate antibiotic therapy, mortality increases by 20% regardless of antimicrobial resistance. This study evaluated the perceived clinical utility of Artificial Intelligence (AI)-powered Clinical Decision Support Systems (CDSSs) (OneChoice and OneChoice [...] Read more.
Bacteremia is a life-threatening condition contributing significantly to sepsis-related mortality worldwide. With delayed appropriate antibiotic therapy, mortality increases by 20% regardless of antimicrobial resistance. This study evaluated the perceived clinical utility of Artificial Intelligence (AI)-powered Clinical Decision Support Systems (CDSSs) (OneChoice and OneChoice Fusion) among specialist physicians managing bacteremia cases. A cross-sectional survey was conducted with 65 unique specialist physicians from multiple medical specialties who were presented with clinical vignettes describing patients with bacteremia and 90 corresponding AI-CDSS recommendations. Participants assessed the perceived helpfulness of AI decision-making, the impact of AI recommendations on their own clinical judgment, and the concordance between AI recommendations and their own clinical judgment, as well as the validity of changing therapy based on CDSS recommendations. The study encompassed a diverse range of bacterial pathogens, with Escherichia coli representing 38.7% of the isolates and 30% being extended-spectrum β-lactamase (ESBL) producers. Findings show that 97.8% [(95% CI: 92.2–99.7%)] of physicians reported that AI facilitated decision-making and substantial concordance (87.8% [95% CI: 79.2–93.7%; Cohen’s κ = 0.76]) between AI recommendations and physicians’ therapeutic recommendations. Stratification by pathogen revealed the highest concordance for Escherichia coli bacteremia (96.6%, 28/29 cases). Implementation analysis revealed a meaningful clinical impact, with 68.9% [(95% CI: 58.3–78.2%)] of cases resulting in AI-guided treatment modifications. These findings indicate that AI-powered CDSSs effectively bridge critical gaps in infectious disease expertise and antimicrobial stewardship, providing clinicians with evidence-based therapeutic recommendations that can be integrated into routine practice to optimize antibiotic selection, particularly in settings with limited access to infectious disease specialists. For optimal clinical integration, we recommend that clinicians utilize AI-CDSS recommendations as an adjunct to clinical judgment rather than a replacement, particularly in complex cases involving immunocompromised hosts or polymicrobial infections. Future research should prioritize prospective clinical trials that evaluate direct patient outcomes to establish evidence of broader clinical effectiveness and applicability across diverse healthcare settings. Full article
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2624 KB  
Proceeding Paper
Sensor Fusion of Doppler Microwave and Multizone ToF for Short-Range Dynamic Object Tracking
by Eren Bülbül and Umut Dolangac
Eng. Proc. 2025, 118(1), 99; https://doi.org/10.3390/ECSA-12-26534 - 7 Nov 2025
Viewed by 60
Abstract
We present a low-cost sensor-fusion system combining a 10.525 GHz CW Doppler microwave sensor with an 8 × 8 Time-of-Flight (ToF) infrared sensor for short-range object tracking. Data are acquired and processed in a sequential fusion pipeline: ToF-based Convolutional Neural Networks (CNNs) estimate [...] Read more.
We present a low-cost sensor-fusion system combining a 10.525 GHz CW Doppler microwave sensor with an 8 × 8 Time-of-Flight (ToF) infrared sensor for short-range object tracking. Data are acquired and processed in a sequential fusion pipeline: ToF-based Convolutional Neural Networks (CNNs) estimate object presence, coordinates, and cross-section, while Doppler histograms yield radial velocity; outputs are then fused at the decision level. A dataset of 31,367 frames was collected. The system tracks objects (≥35 cm2) at speeds up to 10 m/s within 5–250 cm, achieving 98% detection and 84% positioning accuracy. This approach offers radar-like capabilities at a reduced cost, enabling applications in industrial, and consumer-electronics domains. Full article
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19 pages, 6662 KB  
Article
Stigmasterol Protects Against Dexamethasone-Induced Muscle Atrophy by Modulating the FoxO3–MuRF1/MAFbx Signaling Pathway in C2C12 Myotubes and Mouse Skeletal Muscle
by Young-Sool Hah, Seung-Jun Lee, Yeung-Ho Ji, Jeongyun Hwang, Han-Gil Kim, Young-Tae Ju, Jun-Il Yoo and Seung-Jin Kwag
Biomolecules 2025, 15(11), 1551; https://doi.org/10.3390/biom15111551 - 5 Nov 2025
Cited by 1 | Viewed by 957
Abstract
Glucocorticoid therapy, using agents like dexamethasone (Dexa), often leads to muscle atrophy by increasing protein degradation via the ubiquitin–proteasome system while suppressing protein synthesis. Stigmasterol, a phytosterol with known bioactivities, has an unexplored role in muscle atrophy. This study investigated stigmasterol’s protective effects [...] Read more.
Glucocorticoid therapy, using agents like dexamethasone (Dexa), often leads to muscle atrophy by increasing protein degradation via the ubiquitin–proteasome system while suppressing protein synthesis. Stigmasterol, a phytosterol with known bioactivities, has an unexplored role in muscle atrophy. This study investigated stigmasterol’s protective effects against Dexa-induced muscle atrophy and its impact on the FoxO3 and mTORC1 signaling pathways. Differentiated C2C12 myotubes were treated with Dexa (50 µM) ± stigmasterol (10 µM), and the morphology, viability, and protein levels in the FoxO3/MuRF1/MAFbx catabolic and mTOR/p70S6K/4E-BP1 anabolic signaling pathways were assessed. C57BL/6 mice received Dexa (20 mg/kg/day i.p.) ± stigmasterol (3 mg/kg/day oral) for 21 days, and the body/muscle mass, bone mineral density (BMD), fiber cross-sectional area (CSA), and muscle protein expression were measured. Stigmasterol (10 µM) was non-toxic and attenuated Dexa-induced reductions in myotube diameter and fusion in vitro, concurrent with suppressing Dexa-induced upregulation of FoxO3/MuRF1/MAFbx proteins and preventing the Dexa-induced dephosphorylation of mTOR/p70S6K/4E-BP1 proteins. In vivo, stigmasterol mitigated Dexa-induced losses in body weight, muscle mass, BMD, and fiber CSA. This protection was associated with attenuated upregulation of FoxO3 and MAFbx proteins in muscle tissue. Stigmasterol protected against Dexa-induced muscle atrophy in vitro and in vivo via modulation of the FoxO3–MAFbx catabolic pathway. These findings suggest stigmasterol inhibits excessive glucocorticoid-induced muscle protein breakdown. It therefore warrants further investigation as a potential therapeutic agent for glucocorticoid myopathy. Full article
(This article belongs to the Section Molecular Medicine)
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25 pages, 7422 KB  
Article
Vitamin B1 Involved in Dendrobium Taiseed Tosnobile Extract Mediates Protection Against Cancer-Induced Muscle Wasting by Suppressing IL-6 Pathogenicity and Enhancing Myoblast Fusion
by Chen-Chu Lin, Wan-Ting Liao, Tsung-Ying Yang, Jing-Hua Tsai, Yi-Ju Lee, Chi-Luan Wen, Shih-Lan Hsu and Chun-Chi Wu
Int. J. Mol. Sci. 2025, 26(21), 10704; https://doi.org/10.3390/ijms262110704 - 3 Nov 2025
Viewed by 638
Abstract
In this report, we showed that oral administration of Dendrobium Taiseed Tosnobile (DTT, also known as Taiwan Emperor No.1) allowed Lewis Lung Carcinoma (LLC) tumor-bearing mice to maintain body weight and grip strength in a dose-dependent manner. Histological analysis showed that treatment with [...] Read more.
In this report, we showed that oral administration of Dendrobium Taiseed Tosnobile (DTT, also known as Taiwan Emperor No.1) allowed Lewis Lung Carcinoma (LLC) tumor-bearing mice to maintain body weight and grip strength in a dose-dependent manner. Histological analysis showed that treatment with DTT water extract significantly reduced muscle fiber damage by inducing muscle regeneration and improved the cross-sectional area of the rectus femoris, soleus, and gastrocnemius of LLC tumor-bearing C57BL/6 female mice. Further studies revealed that DTT water extract also reduced the expression of inflammatory cytokines such as IL-6 and TNF-α, both in vitro and in vivo. Other analyses showed that DTT water extract promoted the differentiation of C2C12 myoblasts with or without IL-6 by maintaining Myosin Heavy Chain (MyHC) levels. This suggests that DTT water extract acts against muscle wasting via multiple mechanisms. Interestingly, vitamin B1 was identified as an ingredient in DTT water extract through an HPLC analysis. Vitamin B1 was shown to ameliorate IL-6 but not TNF-α generation in active THP-1 cells and protected C2C12 myotubes against IL-6. Further studies showed that DTT and vitamin B1 promoted the multi-nucleus fusion step of C2C12 differentiation by inducing E-cadherin-β-catenin expression with or without IL-6 treatment. In summary, DTT water extract protects muscle cells under cancer conditions through direct and indirect mechanisms, with vitamin B1 being a key functional ingredient that reduces IL-6 generation and aids muscle cell fusion against IL-6 treatment. Full article
(This article belongs to the Special Issue The Role of Natural Products in Treating Human Diseases)
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14 pages, 2956 KB  
Article
Influence of AlSi10Mg Thermophysical Properties on the Melt Pool Morphology During High-Fidelity Simulation of Laser Powder Bed Fusion
by Ivan A. Pelevin, Maria V. Bogdanova, Andrey V. Zakirov, Dmitriy D. Zherebtsov and Stanislav V. Chernyshikhin
Modelling 2025, 6(4), 135; https://doi.org/10.3390/modelling6040135 - 28 Oct 2025
Viewed by 799
Abstract
Laser powder bed fusion (LPBF) is an advanced additive manufacturing method, but its productivity is relatively low, which limits its application. Performance can be increased without hardware modifications by enlarging the powder-layer thickness. However, this approach requires deeper investigation because the probability of [...] Read more.
Laser powder bed fusion (LPBF) is an advanced additive manufacturing method, but its productivity is relatively low, which limits its application. Performance can be increased without hardware modifications by enlarging the powder-layer thickness. However, this approach requires deeper investigation because the probability of defects (keyhole porosity, lack of fusion) rises substantially, and experiments become costly since each thickness value requires a separate LPBF run. High-fidelity simulation under such conditions can reduce the experimental workload. Reliable predictions, however, require numerous thermophysical parameters; reported values are often inconsistent or unavailable, and few studies have quantified their influence on simulation outcomes. A Lattice Boltzmann-based model is adopted to simulate the keyhole melting mode of AlSi10Mg. The effects of laser spot diameter, laser absorptivity, and the temperature dependence of thermal diffusivity and surface tension on the results are investigated. Predicted melt-pool morphologies are compared with cross-sections of experimental single tracks. Full article
(This article belongs to the Special Issue Recent Advances in Computational Fluid Mechanics)
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15 pages, 5984 KB  
Article
Phased Array Ultrasonic Testing of W/EUROFER Functionally Graded Coating
by Ashwini Kumar Mishra and Jarir Aktaa
Materials 2025, 18(21), 4896; https://doi.org/10.3390/ma18214896 - 26 Oct 2025
Viewed by 704
Abstract
W/EUROFER functionally graded material (FGM) plasma-sprayed coatings are used as a protective layer in nuclear fusion applications. It is vital to develop a non-destructive test method to analyze interface characteristics and detect delamination in coatings. A phased array ultrasonic test method was developed [...] Read more.
W/EUROFER functionally graded material (FGM) plasma-sprayed coatings are used as a protective layer in nuclear fusion applications. It is vital to develop a non-destructive test method to analyze interface characteristics and detect delamination in coatings. A phased array ultrasonic test method was developed in this work to analyze the coating interface characteristics. Two types of coated samples were tested: first, a W/EUROFER FGM-coated flat small sample, and secondly, a large-scale L-shape 50% W and 50% EUROFER curve-coated sample. The phased array ultrasonic test method reliably detected two separate interfaces in W/EUROFER FGM coating, and no delamination was detected, which was verified by cross-sectional image analysis. Secondly, the phased array ultrasonic test precisely detected delamination created during deposition in a large-scale L-shape 50% W and 50% EUROFER curve coated sample. The accuracy in detecting delamination was verified by cross-sectional images of the interface. The phased array ultrasonic test was found to be a reliable method for detecting delamination in multilayer coatings from small-scale to large-scale curved components. Full article
(This article belongs to the Special Issue Advancements in Ultrasonic Testing for Metallurgical Materials)
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