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20 pages, 2243 KiB  
Article
Increasing Access and Availability of Nutrient-Dense Foods at United States Marine Corps Food Venues Is Feasible and Profitable
by Katie M. Kirkpatrick, Zina N. Abourjeily, Melissa A. Rittenhouse, Maureen W. Purcell, Rory G. McCarthy and Jonathan M. Scott
Nutrients 2025, 17(15), 2556; https://doi.org/10.3390/nu17152556 - 5 Aug 2025
Abstract
Background/Objectives: Military Service Members (SMs) require optimal nutrition to support health, readiness, and job performance. However, they often fall short of meeting nutrition guidelines. This study aimed to determine the impact and feasibility of implementing the U.S. Marine Corps (USMC) “Fueled to [...] Read more.
Background/Objectives: Military Service Members (SMs) require optimal nutrition to support health, readiness, and job performance. However, they often fall short of meeting nutrition guidelines. This study aimed to determine the impact and feasibility of implementing the U.S. Marine Corps (USMC) “Fueled to Fight®” (F2F) nutrition program in non-appropriated fund (NAF) food venues. Objectives included evaluating changes in Military Nutrition Environment Assessment Tool (mNEAT) scores, feasibility of implementing and maintaining F2F strategies, and influence on customer purchasing patterns. Methods: Researchers conducted a pre-post interventional study from January to December 2024 at three NAF food venues across two USMC bases. F2F strategies, including identifying items using a stoplight color coding system (Green = healthy, Yellow = less healthy, Red = least healthy), menu revisions, food placement, promotion, and marketing, were implemented. Data included mNEAT assessments, sales reports, and stakeholder focus groups. Generalized Estimating Equations models were used to analyze sales data. Results: mNEAT scores increased across all venues post-intervention. Availability and sales of Green items increased, while sales of Red items decreased in some venues. Profit increased at all three food venues. Focus groups revealed feasibility and provided insights for future interventions. Conclusions: F2F interventions in NAF food venues are feasible and can positively impact the food environment and customer purchasing patterns without negatively affecting profit. This study highlights the importance of integrating nutrition programs into all military food venues, not just government-funded dining facilities, to support the nutritional fitness and readiness of SMs. Full article
(This article belongs to the Section Nutrition and Public Health)
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21 pages, 1260 KiB  
Review
Comprehensive Overview Assessment on Legal Guarantee System of Wetland Carbon Sink Trading for One Belt and One Road Initiative
by Jingjing Min, Wanwu Yuan, Wei He, Pingping Luo, Hanming Zhang and Yang Zhao
Land 2025, 14(8), 1583; https://doi.org/10.3390/land14081583 - 3 Aug 2025
Viewed by 235
Abstract
The countries and regions along the Belt and Road are rich in wetland carbon sink resources, crucial for mitigating greenhouse gas emissions and achieving global emission reduction. This paper uses policy analysis and desk research to analyze the overview of wetland carbon sinks [...] Read more.
The countries and regions along the Belt and Road are rich in wetland carbon sink resources, crucial for mitigating greenhouse gas emissions and achieving global emission reduction. This paper uses policy analysis and desk research to analyze the overview of wetland carbon sinks in these countries. It explores the necessity of legal system construction for their carbon sink trading. This study finds that smooth trading requires clear property rights definition rules, efficient market trading entities, definite carbon sink trading price rules, financial support aligned with the Equator Principles, and support from biodiversity-compatible environmental regulatory principles. Currently, there are still obstacles in wetland carbon sink trading in the Belt and Road, such as property rights confirmation, an accounting system, an imperfect market trading mechanism, and the coexistence of multiple trading risks. Therefore, this paper first proposes to clarify the goal of the legal guarantee mechanism. Efforts should focus on promoting a consensus on wetland carbon sink ownership and establishing a unified accounting standard system; simultaneously, the relevant departments should conduct field investigations and monitoring, standardize the market order, and strengthen government financial support and funding guarantees. Full article
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19 pages, 5488 KiB  
Article
Treatment of Recycled Metallurgical By-Products for the Recovery of Fe and Zn Through a Plasma Reactor and RecoDust
by Wolfgang Reiter, Loredana Di Sante, Vincenzo Pepe, Marta Guzzon and Klaus Doschek-Held
Metals 2025, 15(8), 867; https://doi.org/10.3390/met15080867 (registering DOI) - 1 Aug 2025
Viewed by 147
Abstract
The 1.9 billion metric tons of steel globally manufactured in 2023 justify the steel industry’s pivotal role in modern society’s growth. Considering the rapid development of countries that have not fully taken part in the global market, such as Africa, steel production is [...] Read more.
The 1.9 billion metric tons of steel globally manufactured in 2023 justify the steel industry’s pivotal role in modern society’s growth. Considering the rapid development of countries that have not fully taken part in the global market, such as Africa, steel production is expected to increase in the next decade. However, the environmental burden associated with steel manufacturing must be mitigated to achieve sustainable production, which would align with the European Green Deal pathway. Such a burden is associated both with the GHG emissions and with the solid residues arising from steel manufacturing, considering both the integrated and electrical routes. The valorisation of the main steel residues from the electrical steelmaking is the central theme of this work, referring to the steel electric manufacturing in the Dalmine case study. The investigation was carried out from two different points of view, comprising the action of a plasma electric reactor and a RecoDust unit to optimize the recovery of iron and zinc, respectively, being the two main technologies envisioned in the EU-funded research project ReMFra. This work focuses on those preliminary steps required to detect the optimal recipes to consider for such industrial units, such as thermodynamic modelling, testing the mechanical properties of the briquettes produced, and the smelting trials carried out at pilot scale. However, tests for the usability of the dusty feedstock for RecoDust are carried out, and, with the results, some recommendations for pretreatment can be made. The outcomes show the high potential of these streams for metal and mineral recovery. Full article
33 pages, 1129 KiB  
Article
Toward a ‘Green Intelligence’? The Intelligence Practices of Non-Governmental Organisations Which Combat Environmental Crime
by Charlotte M. Davies
Laws 2025, 14(4), 52; https://doi.org/10.3390/laws14040052 - 28 Jul 2025
Viewed by 527
Abstract
Environmental crime has been increasingly recognised as transnational organised crime, but efforts to build a coherent and effective international response are still in development and under threat from shifts in the funding landscape. This mixed methods study addresses the role of one significant [...] Read more.
Environmental crime has been increasingly recognised as transnational organised crime, but efforts to build a coherent and effective international response are still in development and under threat from shifts in the funding landscape. This mixed methods study addresses the role of one significant group of actors in environmental crime enforcement, which are non-governmental organisations (NGOs) who gather intelligence that can be shared with law enforcement and regulatory agencies. The study compares their intelligence practices to findings from traditional intelligence sectors, with a focus upon criminal justice and policing. The research generated quantitative and qualitative data from NGO practitioners, which is integrated to discern three overarching themes inherent in these NGOs’ intelligence practices: the implementation of formal intelligence practices is still underway in the sector; there remains a need to improve cooperation to break down silos between agencies and NGOs, which requires an improvement in trust between these entities; the operating environment provides both opportunities and challenges to the abilities of the NGOs to deliver impact. The study concludes by positing that the characteristics of NGOs mean that this situation constitutes ‘green intelligence’, contextualising intelligence theory and highlighting areas in which agencies can further combat environmental crime. Full article
(This article belongs to the Special Issue Global Threats in the Illegal Wildlife Trade and Advances in Response)
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21 pages, 727 KiB  
Article
Cost-Effective Energy Retrofit Pathways for Buildings: A Case Study in Greece
by Charikleia Karakosta and Isaak Vryzidis
Energies 2025, 18(15), 4014; https://doi.org/10.3390/en18154014 - 28 Jul 2025
Viewed by 219
Abstract
Urban areas are responsible for most of Europe’s energy demand and emissions and urgently require building retrofits to meet climate neutrality goals. This study evaluates the energy efficiency potential of three public school buildings in western Macedonia, Greece—a cold-climate region with high heating [...] Read more.
Urban areas are responsible for most of Europe’s energy demand and emissions and urgently require building retrofits to meet climate neutrality goals. This study evaluates the energy efficiency potential of three public school buildings in western Macedonia, Greece—a cold-climate region with high heating needs. The buildings, constructed between 1986 and 2003, exhibited poor insulation, outdated electromechanical systems, and inefficient lighting, resulting in high oil consumption and low energy ratings. A robust methodology is applied, combining detailed on-site energy audits, thermophysical diagnostics based on U-value calculations, and a techno-economic assessment utilizing Net Present Value (NPV), Internal Rate of Return (IRR), and SWOT analysis. The study evaluates a series of retrofit measures, including ceiling insulation, high-efficiency lighting replacements, and boiler modernization, against both technical performance criteria and financial viability. Results indicate that ceiling insulation and lighting system upgrades yield positive economic returns, while wall and floor insulation measures remain financially unattractive without external subsidies. The findings are further validated through sensitivity analysis and policy scenario modeling, revealing how targeted investments, especially when supported by public funding schemes, can maximize energy savings and emissions reductions. The study concludes that selective implementation of cost-effective measures, supported by public grants, can achieve energy targets, improve indoor environments, and serve as a replicable model of targeted retrofits across the region, though reliance on external funding and high upfront costs pose challenges. Full article
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20 pages, 304 KiB  
Article
Normative Power and Europeanization: The EU’s Global Agenda for Gender Equality
by Oana-Andreea Ion, Gabriela-Roxana Irod and Cristian Pîrvulescu
Societies 2025, 15(8), 208; https://doi.org/10.3390/soc15080208 - 27 Jul 2025
Viewed by 374
Abstract
This article explores how the European Union (EU) promotes gender equality beyond its borders, situating the analysis within broader debates on external Europeanization and normative power. While most studies have examined the domestic impact of EU policies, this paper focuses on how gender [...] Read more.
This article explores how the European Union (EU) promotes gender equality beyond its borders, situating the analysis within broader debates on external Europeanization and normative power. While most studies have examined the domestic impact of EU policies, this paper focuses on how gender equality norms are projected internationally and conceptually investigates the mechanisms involved in their diffusion. Drawing on existing theoretical literature, the article analyzes how EU-level normative strategies may interact with domestic political, institutional, and societal dynamics in third countries, often in complex and contested ways. Rather than providing empirical testing, the study identifies core mechanisms—such as strategic communication, partnerships, and funding tools—and reflects on their limitations and the role of local agency in interpreting or resisting EU-promoted norms. The findings highlight the difficulty of isolating EU influence from other international and transnational drivers of norm diffusion, and the need for caution in attributing policy shifts solely to EU action. The article concludes that a better understanding of these processes requires more attention to domestic contexts, as well as future empirical research to complement conceptual analyses of Europeanization in sensitive policy domains such as gender equality. Full article
24 pages, 74760 KiB  
Article
The Application of Mobile Devices for Measuring Accelerations in Rail Vehicles: Methodology and Field Research Outcomes in Tramway Transport
by Michał Urbaniak, Jakub Myrcik, Martyna Juda and Jan Mandrysz
Sensors 2025, 25(15), 4635; https://doi.org/10.3390/s25154635 - 26 Jul 2025
Viewed by 423
Abstract
Unbalanced accelerations occurring during tram travel have a significant impact on passenger comfort and safety, as well as on the rate of wear and tear on infrastructure and rolling stock. Ideally, these dynamic forces should be monitored continuously in real-time; however, traditional systems [...] Read more.
Unbalanced accelerations occurring during tram travel have a significant impact on passenger comfort and safety, as well as on the rate of wear and tear on infrastructure and rolling stock. Ideally, these dynamic forces should be monitored continuously in real-time; however, traditional systems require high-precision accelerometers and proprietary software—investments often beyond the reach of municipally funded tram operators. To this end, as part of the research project “Accelerometer Measurements in Rail Passenger Transport Vehicles”, pilot measurement campaigns were conducted in Poland on tram lines in Gdańsk, Toruń, Bydgoszcz, and Olsztyn. Off-the-shelf smartphones equipped with MEMS accelerometers and GPS modules, running the Physics Toolbox Sensor Suite Pro app, were used. Although the research employs widely known methods, this paper addresses part of the gap in affordable real-time monitoring by demonstrating that, in the future, equipment equipped solely with consumer-grade MEMS accelerometers can deliver sufficiently accurate data in applications where high precision is not critical. This paper presents an analysis of a subset of results from the Gdańsk tram network. Lateral (x) and vertical (z) accelerations were recorded at three fixed points inside two tram models (Pesa 128NG Jazz Duo and Düwag N8C), while longitudinal accelerations were deliberately omitted at this stage due to their strong dependence on driver behavior. Raw data were exported as CSV files, processed and analyzed in R version 4.2.2, and then mapped spatially using ArcGIS cartograms. Vehicle speed was calculated both via the haversine formula—accounting for Earth’s curvature—and via a Cartesian approximation. Over the ~7 km route, both methods yielded virtually identical results, validating the simpler approach for short distances. Acceleration histograms approximated Gaussian distributions, with most values between 0.05 and 0.15 m/s2, and extreme values approaching 1 m/s2. The results demonstrate that low-cost mobile devices, after future calibration against certified accelerometers, can provide sufficiently rich data for ride-comfort assessment and show promise for cost-effective condition monitoring of both track and rolling stock. Future work will focus on optimizing the app’s data collection pipeline, refining standard-based analysis algorithms, and validating smartphone measurements against benchmark sensors. Full article
(This article belongs to the Collection Sensors and Actuators for Intelligent Vehicles)
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16 pages, 777 KiB  
Communication
The Platform Readiness Dashboard: A Tool for Evaluating Vaccine Platform Suitability for a Rapid Response to Epidemic and Pandemic Threats
by Ramin Sabet-Azad, Catherine Hoath, Nicole Bézay and Anna Särnefält
Vaccines 2025, 13(8), 793; https://doi.org/10.3390/vaccines13080793 - 26 Jul 2025
Viewed by 884
Abstract
Rapid vaccine availability is essential for effective epidemic and pandemic response. Building on the Coalition for Epidemic Preparedness Innovations (CEPI) 100 Days Mission, which aims to have new vaccines ready for initial authorization and manufacturing at scale within 100 days of recognition of [...] Read more.
Rapid vaccine availability is essential for effective epidemic and pandemic response. Building on the Coalition for Epidemic Preparedness Innovations (CEPI) 100 Days Mission, which aims to have new vaccines ready for initial authorization and manufacturing at scale within 100 days of recognition of a pandemic pathogen, the CEPI has developed a Chemistry, Manufacturing and Controls (CMC) Rapid Response Framework to define technical and logistical CMC requirements to enable rapid vaccine availability. Central to this framework is the availability of adaptable vaccine platforms that can be readily tailored to emerging pathogens. To support strategic decision-making and identify gaps in platform capabilities, CEPI has created the Platform Readiness Dashboard. This tool provides a structured, multi-dimensional initial assessment of platform maturity across six key categories: Adaptability, Compatibility, Suitability, Regulatory, Manufacturing, and Facility Readiness. Each category includes specific technical and operational considerations scored using a color-coded system to reflect outbreak response readiness level. This Dashboard aims to enable vaccine developers, manufacturers, funders, and outbreak response teams to evaluate platform strengths and limitations at any given time, informing funding, preparedness and response activities. By offering a dynamic view of essential platform readiness indicators, the dashboard can communicate progress supporting faster responses to future health emergencies. Full article
(This article belongs to the Special Issue Estimating Vaccines' Value and Impact)
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16 pages, 4736 KiB  
Review
Volcanic Islands as Reservoirs of Geoheritage: Current and Potential Initiatives of Geoconservation
by Esther Martín-González, Juana Vegas, Inés Galindo, Carmen Romero and Nieves Sánchez
J. Mar. Sci. Eng. 2025, 13(8), 1420; https://doi.org/10.3390/jmse13081420 - 25 Jul 2025
Viewed by 317
Abstract
Volcanic islands host exceptional geological features that illustrate complex endogenic processes and interactions with climatic and marine forces, while also being particularly vulnerable to the impacts of climate change. Despite their scientific, educational, touristic, and aesthetic values, such islands remain underrepresented within the [...] Read more.
Volcanic islands host exceptional geological features that illustrate complex endogenic processes and interactions with climatic and marine forces, while also being particularly vulnerable to the impacts of climate change. Despite their scientific, educational, touristic, and aesthetic values, such islands remain underrepresented within the UNESCO Global Geoparks (UGGp). This study reviews current volcanic island geoparks and evaluates territories with potential for future designation, based on documented geoheritage, geosite inventories, and geoconservation frameworks. Geoparks are categorized according to their dominant narratives—ranging from recent Quaternary volcanism to broader tectonic, sedimentary, and metamorphic histories. Through an analysis of their distribution, management strategies, and integration into territorial planning, this work highlights the challenges that insular territories face, including vulnerability to global environmental change, limited legal protection, and structural inequalities in access to international resources recognition. It concludes that volcanic island geoparks represent strategic platforms for implementing sustainable development models, especially in ecologically and socially fragile contexts. Enhancing their global representation will require targeted efforts in ecologically and socially fragile contexts. Enhancing their global representation will require targeted efforts in capacity building, funding access, and regional cooperation—particularly across the Global South. Full article
(This article belongs to the Special Issue Feature Review Papers in Geological Oceanography)
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10 pages, 314 KiB  
Communication
Simplifying Antibiotic Management of Peritonitis in APD: Evidence from a Non-Inferiority Randomized Trial
by Jesús Venegas-Ramírez, Benjamín Trujillo-Hernández, Carmen Citlalli Castillón-Flores, Fernanda Janine Landín-Herrera, Erika Herrera-Oliva, Patricia Calvo-Soto, Rosa Tapia-Vargas, Alejandro Figueroa-Gutiérrez, Eder Fernando Ríos-Bracamontes, Karina Esmeralda Espinoza-Mejía, Iris Anecxi Jiménez-Vieyra, Luis Antonio Bermúdez-Aceves, Blanca Judith Ávila-Flores and Efrén Murillo-Zamora
Antibiotics 2025, 14(8), 747; https://doi.org/10.3390/antibiotics14080747 - 24 Jul 2025
Viewed by 362
Abstract
Introduction/Objective: Peritonitis remains a serious complication in patients undergoing automated peritoneal dialysis (APD), requiring prompt and effective antibiotic administration. This study evaluated whether delivering antibiotics directly through APD bags is as effective as administering them via an additional manual daytime exchange. Methods: We [...] Read more.
Introduction/Objective: Peritonitis remains a serious complication in patients undergoing automated peritoneal dialysis (APD), requiring prompt and effective antibiotic administration. This study evaluated whether delivering antibiotics directly through APD bags is as effective as administering them via an additional manual daytime exchange. Methods: We conducted a randomized, single-blind, non-inferiority clinical trial involving patients diagnosed with peritonitis. Participants were randomly assigned to receive Ceftazidime and Vancomycin, either via APD bags or through a combined approach of continuous ambulatory peritoneal dialysis (CAPD) plus APD. A total of 64 patients (32 per group) were enrolled, with comparable baseline demographic and clinical profiles, including laboratory markers of infection severity and dialysis history. Results: Peritonitis resolved in 90.6% of the patients treated via APD bags and in 81.3% of those receiving antibiotics through manual exchange plus APD. Although this difference did not reach statistical significance (p = 0.281), the observed absolute difference of 9.3% was well within the predefined non-inferiority margin of 30%, supporting the clinical non-inferiority of the APD-only method. The mean time to resolution was similar between groups (p = 0.593). Post hoc power analyses indicated limited statistical power (18.5% for the resolution rate and 9.2% for time to resolution), suggesting that modest differences may not have been detectable given the sample size. Nevertheless, the high resolution rates observed in both groups reflect valid and encouraging clinical outcomes. Conclusion: Antibiotic administration via APD bags demonstrated comparable clinical effectiveness to the combined manual exchange plus APD method for treating peritonitis. Given its operational simplicity and favorable results, the APD-only strategy may offer a pragmatic alternative in routine care. Further studies with larger sample sizes are recommended to confirm these findings and optimize treatment protocols. Trial registration: NCT04077996. Funding source: None to declare. Full article
(This article belongs to the Section Antibiotic Therapy in Infectious Diseases)
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23 pages, 1309 KiB  
Review
Development and Transfer of Microbial Agrobiotechnologies in Contrasting Agrosystems: Experience of Kazakhstan and China
by Aimeken M. Nygymetova, Assemgul K. Sadvakasova, Dilnaz E. Zaletova, Bekzhan D. Kossalbayev, Meruyert O. Bauenova, Jingjing Wang, Zhiyong Huang, Fariza K. Sarsekeyeva, Dariga K. Kirbayeva and Suleyman I. Allakhverdiev
Plants 2025, 14(14), 2208; https://doi.org/10.3390/plants14142208 - 17 Jul 2025
Viewed by 499
Abstract
The development and implementation of microbial consortium-based biofertilizers represent a promising direction in sustainable agriculture, particularly in the context of the ongoing global ecological and agricultural crisis. This article examines the agroecological and economic impacts of applying microbial consortiums and explores the mechanisms [...] Read more.
The development and implementation of microbial consortium-based biofertilizers represent a promising direction in sustainable agriculture, particularly in the context of the ongoing global ecological and agricultural crisis. This article examines the agroecological and economic impacts of applying microbial consortiums and explores the mechanisms of technology transfer using the example of two countries with differing levels of scientific and technological advancement–China and Kazakhstan. The analysis of the Chinese experience reveals that the successful integration of microbial biofertilizers into agricultural practice is made possible by a well-established institutional framework that includes strong governmental support for R&D, a robust scientific infrastructure, and effective coordination with the private sector. In contrast, Kazakhstan, despite its favorable agroecological conditions and growing interest among farmers in environmentally friendly technologies, faces several challenges from limited funding to a fragmented technology transfer system. The comparative study demonstrates that adapting Chinese models requires consideration of local specificities and the strengthening of intergovernmental cooperation. The article concludes by emphasizing the need to establish a multi-level innovation ecosystem encompassing the entire cycle of development and deployment of microbial biofertilizers, as a prerequisite for improving agricultural productivity and ensuring food security in countries at different stages of economic development. Full article
(This article belongs to the Special Issue Emerging Trends in Alternative and Sustainable Crop Production)
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23 pages, 1026 KiB  
Article
Systemic Factors Fuel Food Insecurity Among Collegiate Student-Athletes: Qualitative Findings from the Running on Empty Study
by Barbara Gordon, Natalie Christensen and Jenifer Reader
Nutrients 2025, 17(14), 2254; https://doi.org/10.3390/nu17142254 - 8 Jul 2025
Viewed by 413
Abstract
Collegiate student-athletes are particularly vulnerable to food insecurity (FI). Prevalence rates range from 9.9% to 65%, although research is limited among this population. Background/Objectives: The challenge of balancing academic and degree progression requirements with training and competition demands can increase the risk for [...] Read more.
Collegiate student-athletes are particularly vulnerable to food insecurity (FI). Prevalence rates range from 9.9% to 65%, although research is limited among this population. Background/Objectives: The challenge of balancing academic and degree progression requirements with training and competition demands can increase the risk for FI among student-athletes. Furthermore, insufficient funds for food has been reported for student-athletes living both on campus and off campus. Methods: This qualitative study employed a phenomenological design and constructivist theoretical framework to explore the experiences of athletic trainers, sports dietitians/nutritionists, and other professionals working with student-athletes in identifying and addressing FI among student-athletes via a series of online focus groups. Results: Participants (n = 27, 12 public colleges) had ≥7 years of collegiate athletics work experience, and most had been in their current position for <3 years. Five approaches to FI screening emerged; specifically, no screening, screening varies by team/sport, informal screening, dietitian screening, and formal screening. Emerging social determinants of FI included financial challenges, competing priorities, cultural/societal impacts, limited life skills, and the food environment. All these factors precipitated on a systems level, including individual, team/athletic department, and university/societal tiers. Conclusions: Athletic department and university policies and budgetary decisions emerged as potential antagonists of food security among student-athletes. FI mitigation strategies for student-athletes must go beyond simply addressing individual factors. Obtainment of food security among collegiate student-athletes requires system changes at the team/athletic department and university tiers. Full article
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50 pages, 3939 KiB  
Review
Targeting Gram-Negative Bacterial Biofilm with Innovative Therapies: Communication Silencing Strategies
by Milka Malešević and Branko Jovčić
Future Pharmacol. 2025, 5(3), 35; https://doi.org/10.3390/futurepharmacol5030035 - 3 Jul 2025
Viewed by 638
Abstract
Biofilm-associated infections caused by Gram-negative bacteria, especially multidrug-resistant strains, frequently occur in intensive care units and represent a major therapeutic challenge. The economic burden of biofilm-associated infections is considerable, making the search for new treatment approaches a focal point for policymakers and scientific [...] Read more.
Biofilm-associated infections caused by Gram-negative bacteria, especially multidrug-resistant strains, frequently occur in intensive care units and represent a major therapeutic challenge. The economic burden of biofilm-associated infections is considerable, making the search for new treatment approaches a focal point for policymakers and scientific funding bodies. Biofilm formation is regulated by quorum sensing (QS), a population density-dependent communication mechanism between cells mediated by small diffusible signaling molecules. QS modulates various intracellular processes, and some features of QS are common to all Gram-negative bacteria. While there are differences in the QS regulatory networks of different Gram-negative bacterial species, a common feature of most Gram-negative bacteria is the ability of N-acylhomoserine lactones (AHL) as inducers to diffuse across the bacterial membrane and interact with receptors located either in the cytoplasm or on the inner membrane. Targeting QS by inhibiting the synthesis, transport, or perception of signaling molecules using small molecules, quorum quenching enzymes, antibodies, combinatorial therapies, or nanoparticles is a promising strategy to combat virulence. In-depth knowledge of biofilm biology, antibiotic susceptibility, and penetration mechanisms, as well as a deep understanding of anti-QS agents, will contribute to the development of antimicrobial therapies to combat biofilm infections. Advancing antimicrobial therapies against biofilm infections requires a deep understanding of biofilm biology, antibiotic susceptibility, penetration mechanisms, and anti-QS strategies. This can be achieved through in vivo and clinical studies, supported by state-of-the-art tools such as machine learning and artificial intelligence. Full article
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6 pages, 229 KiB  
Proceeding Paper
Reliability of Electro-Power Equipment Determined by Data in Its Operation and Storage
by Nikolay Gueorguiev, Atanas Nachev, Yavor Boychev, Konstantin Nesterov and Svetlana Yaneva
Eng. Proc. 2025, 100(1), 5; https://doi.org/10.3390/engproc2025100005 - 1 Jul 2025
Viewed by 195
Abstract
The reliability of the electro-power equipment of electrical power transmission systems is essential in ensuring an uninterrupted power supply with the necessary voltage and frequency stability. This is especially important when performing lengthy procedures requiring the serviceability of the electrical equipment used, such [...] Read more.
The reliability of the electro-power equipment of electrical power transmission systems is essential in ensuring an uninterrupted power supply with the necessary voltage and frequency stability. This is especially important when performing lengthy procedures requiring the serviceability of the electrical equipment used, such as those related to foundries and metallurgical processes, or with the processes of testing complex means for the remote control of electromagnetic radiation within the implementation of the Sustainable development of the Competence Center “Quantum Communication, Intelligent Security Systems and Risk Management” (QUASAR) Project, funded with the participation of the EU under the “Research, Innovation and Digitalization for Smart Transformation” Program 2021.2027 according to procedure BG16RFPR002-1.014. One of the main issues in this case is related to the availability of information regarding the technical condition of the deployed or reserve energy resources. In this connection, this study proposes methods for determining the quantity of operational equipment that is either in use or in storage, based on the reliability testing of a representative sample of it. Full article
25 pages, 1166 KiB  
Review
Beyond Smoking: Emerging Drivers of COPD and Their Clinical Implications in Low- and Middle-Income Countries: A Narrative Review
by Ramona Cioboata, Mara Amalia Balteanu, Denisa Maria Mitroi, Sidonia Catalina Vrabie, Silviu Gabriel Vlasceanu, Gabriela Marina Andrei, Anca Lelia Riza, Ioana Streata, Ovidiu Mircea Zlatian and Mihai Olteanu
J. Clin. Med. 2025, 14(13), 4633; https://doi.org/10.3390/jcm14134633 - 30 Jun 2025
Viewed by 452
Abstract
Chronic obstructive pulmonary disease (COPD) is an escalating global health burden, with a disproportionate impact on low- and middle-income countries (LMICs). Although tobacco smoking is a well-established risk factor, emerging evidence highlights the significant role of non-smoking exposure in driving the prevalence of [...] Read more.
Chronic obstructive pulmonary disease (COPD) is an escalating global health burden, with a disproportionate impact on low- and middle-income countries (LMICs). Although tobacco smoking is a well-established risk factor, emerging evidence highlights the significant role of non-smoking exposure in driving the prevalence of COPD in these regions. This narrative review synthesizes current data on key non-smoking contributors, including household air pollution, ambient urban pollution, occupational exposure, early-life respiratory insults, chronic infections, and socioeconomic adversity. These risk factors are associated with distinct COPD phenotypes, often marked by increased airway inflammation, reduced emphysema, and variable airflow limitation. Such presentations are particularly common among women and younger populations in LMICs. However, diagnostic and therapeutic challenges persist, owing to limited disease awareness, under-resourced health systems, restricted access to essential medications, and financial constraints impacting adherence. Despite the proven effectiveness of non-pharmacological measures and public health interventions, their implementation remains inadequate because of infrastructural and funding limitations. Bridging these gaps requires region-specific clinical guidelines, improved diagnostic infrastructure, expanded access to affordable treatment, and culturally sensitive interventions. Future priorities include identifying robust biomarkers, refining disease definitions to accommodate non-smoking phenotypes, and advancing implementation science to improve interventions. A coordinated, context-aware global response is essential to reduce the growing burden of COPD in LMICs and to ensure equitable respiratory health outcomes. Full article
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