Search Results (2,511)

In this paper, a reconfigurable multi-form radar compound coherent jamming signal generator is proposed based on a dual-polarization quadrature phase shift keying (DP-QPSK) modulator cascaded with an intensity modulator (IM). The radar signal and jamming seed signal are loaded on the upper path and the lower path of the DP-QPSK modulator to achieve carrier-suppressed single-sideband (CS-SSB) modulation and phase modulation, respectively. The periodic rectangular pulse (PRP) signal is fed into the IM to achieve interrupted-sampling repeater jamming in the optical domain. In our proposed scheme, cosine phase modulation and interrupted-sampling repeater jamming (CPMJ-ISRJ) and frequency shift and interrupted-sampling repeater jamming (FSJ-ISRJ) are obtained only by changing the form of the jamming seed signal, without changing the overall structure of the scheme. The jamming effectiveness of the above schemes is evaluated through simulation. Multiple false targets are obtained after cross-correlation with the original radar signal. The number of generated false targets can reach 18. We also conducted a detailed simulation to analyze the impact of different parameters on the jamming effect. Because the scheme is filter-free, it has a large frequency tuning range. Moreover, due to the special CS-SSB modulation, the modulated signals are immune to the chromatic dispersion-induced power fading effect. The proposed scheme has potential application prospects in future electronic countermeasure systems. Full article

Background: Herpes zoster (HZ), commonly known as shingles, and post-herpetic neuralgia (PHN) represent growing public health concerns, particularly among older adults. Despite the established efficacy of the herpes zoster vaccine (HZV), global uptake remains suboptimal. Objectives: This scoping review maps evidence from Saudi Arabia evaluating the baseline knowledge, awareness, attitudes, acceptance, hesitancy, and clinical uptake of the HZV among general adults, high-risk populations, and healthcare workers (HCWs). Methods: The JBI and PRISMA-ScR methodological frameworks were strictly adhered to during mapping. Eligible sources included peer-reviewed, observational cross-sectional studies conducted in Saudi Arabia and published in English between 2022 and 2026. The search was conducted across PubMed, Scopus, Web of Science, and Google Scholar. Data were systematically extracted and charted using a standardized digital piloting framework to capture study characteristics (author, year, and region), sample sizes, target populations, knowledge percentages, actual vaccine uptake rates, and self-reported barriers. Results: Out of 25 retrieved records, 19 unique primary studies were mapped. Public knowledge of HZ complications and vaccine eligibility criteria was consistently low to moderate, falling below 50% across most cohorts. Conversely, while verbal willingness to receive the vaccine was highly favorable (ranging from 60% to 75%), a profound “intention–behavior gap” was observed, with actual clinical uptake being below 10%. Key barriers included a lack of public health campaigns, safety concerns regarding reactogenicity, online misinformation, and a lack of proactive provider communication. For HCWs, barriers included unclear local guidelines and a lack of workplace mandates. Ultimately, a proactive physician recommendation was identified as the single most powerful clinical facilitator, increasing vaccine acceptance by over 80% across all cohorts. Conclusions: While the shingles vaccine is now distributed completely free across Saudi Arabia, high public willingness has not translated into actual vaccination rates (10%) due to low public awareness of disease severity. Free vaccine availability alone is insufficient; primary care systems must shift from a passive delivery model to an active, provider-driven framework to successfully close this gap Full article

Electrical measurements of emerging materials such as thin films, two-dimensional materials, and fragile porous systems are often hindered by damage and contamination caused by conventional contact methods, including metal electrode deposition. In this study, we demonstrate the novelty and advantages of a mechanically compliant “soft probe” over conventional methods and conductive AFM. The non-destructive soft probe achieves stable electrical contact in the repulsive-force regime using a hairpin-shaped spring structure, allowing consistent measurements without active force control nor electrode fabrication. Case studies demonstrate that the soft probe prevents metal penetration and preserves intrinsic properties, as demonstrated in NiO resistive switching devices, and improves interface quality compared to deposited electrodes in ferroelectric measurements. It also enables electrical characterization of fragile materials such as metal–organic frameworks without inducing structural degradation. Furthermore, its mechanical compliance ensures stable operation under vibration and thermal stress, enabling measurements in vacuum and low-temperature environments. These results indicate that the soft probe provides a simple, versatile, and contamination-free platform for reliable electrical measurements, and represents a promising approach for the characterization of a wide range of emerging material systems. Full article

Selective androgen receptor modulators (SARMs) are commonly described as tissue-selective anabolic agents, yet the extent to which this selectivity is reflected at the level of receptor-binding energetics remains uncertain. This study evaluated the receptor interaction profiles of the steroidal SARM YK11 and the nonsteroidal SARM ostarine across five steroid hormone nuclear receptors. Flexible molecular docking was performed with AutoDock 4.2 against the androgen (AR), estrogen (ER), progesterone (PR), glucocorticoid (GR), and mineralocorticoid (MR) receptors, using testosterone, estradiol, progesterone, cortisol, and aldosterone as endogenous reference ligands. Binding free energy, docking-derived inhibition constants, intermolecular interaction energies, conformational sampling, and two-dimensional interaction maps were analyzed. Ostarine showed favorable binding across all receptor systems, with binding energies ranging from −10.42 to −12.05 kcal/mol and no pronounced energetic preference for the androgen receptor. YK11 displayed stronger predicted binding, particularly toward the glucocorticoid, progesterone, and androgen receptors, with a docking energy trend of GR > PR > AR > MR > ER. Interaction analysis revealed conserved polar anchoring residues across receptor pockets, together with scaffold-specific contacts that may explain cross-receptor compatibility. These findings indicate that, within the AutoDock 4.2 flexible docking framework applied in this study, docking-derived binding energies primarily describe thermodynamic compatibility with nuclear receptor ligand-binding domains and should not be interpreted as direct predictors of functional SARM tissue selectivity. The observed discordance between predicted receptor affinity and the established tissue-selective pharmacology of ostarine highlights the need for caution when using single-method docking workflows to infer selectivity among closely related steroid hormone receptors. The novelty of this study lies in demonstrating, using a defined AutoDock 4.2-based comparative protocol, that receptor-binding energetics alone do not recapitulate the functional tissue-selective behavior attributed to SARMs. Full article

A portable OCT scanner usable for dental applications is designed to be compact (B4 notebook size), lightweight, and capable of DC battery operation, enabling chairside use and mobility in home medical care. TD-OCT faces the challenge of a slower measurement speed compared to SD/SS-OCT. In this study, by utilizing multiple rotating reflectors and combining them with a 3 × 3 fiber coupler, a measurement range of over 10 mm and a measurement speed of 1000 scans per second were achieved. Additionally, the dental intraoral probe was designed to ensure high accessibility, allowing free positioning within the oral cavity, with an ingeniously compact optical system. A cylindrical probe with a diameter of 6 mmϕ and a length of 10 mm was developed to enable tooth measurement. This study demonstrated the capability to evaluate attenuation coefficients derived from material properties, starting with measurements of caries and gums. Full article

Countermovement jump (CMJ) analysis is widely used to assess lower limb neuromuscular function, but commercial force plates often suffer from high cost, closed algorithms, and lack of bilateral independent measurement. This study developed and evaluated a dual channel strain gauge force plate system featuring open architecture and hardware-triggered video synchronization. The system consists of two physically isolated plates, each with four full bridge strain beams, a precision analog front end, and a 2000 Hz acquisition unit. A microcontroller-based hardware trigger synchronizes force data with video capture. Custom host software implements adaptive jump phase recognition and calculates peak force (PF), concentric impulse, jump height, rate of force development (RFD), and asymmetry index (ASI). Validation included static mass measurements in 14 participants, low-load static calibration (5.0–30.0 kg), free-fall impulse validation (7.00 to 31.32 N·s), 240 fps high-speed video cross validation of flight time, ecological-validity comparison with published AMTI-based force-plate data, and 48 h test–retest reliability assessment. Static mass measurement showed a mean absolute percentage error (MAPE) of 1.01% and a coefficient of determination (R²) of 0.9992, while low-load testing confirmed excellent linearity (R² > 0.996) and minimal absolute error (mean absolute error = 0.34 kg) at lighter weights. Dynamic impulse validation yielded R² > 0.997 and MAPE < 3%. Flight time agreement with high-speed video was within ±10 ms. Test–retest reliability was excellent for concentric impulse (intraclass correlation coefficient (ICC) = 0.997) and jump height (ICC = 0.987), and good for PF (ICC = 0.962) and rate of force development at 100 ms (RFD_100ms) (ICC = 0.883). The physically isolated dual-plate architecture effectively captured bilateral force differences, although the ASI demonstrated moderate reliability (ICC = 0.748), likely reflecting the inherent biological variability in bilateral coordination. The ecological-validity comparison further indicated that the macroscopic kinetic outputs of the proposed system fell within the expected physiological and biomechanical ranges reported for adult CMJ testing. Overall, these findings support the study hypothesis that the proposed dual-channel force plate system provides a valid, reliable, and cost-effective solution for synchronized bilateral CMJ kinetic assessment in sports performance monitoring and biomechanical research, while offering improved accessibility through an open-source and transparent analysis framework with a hardware cost below 500 USD. Full article

Single-photon detection is a promising approach for low–slow–small Unmanned Aerial Vehicle (UAV) detection, holding great value in urban air defense and security monitoring. In complex urban environments, intense non-uniform building clutter and multi-echo aliasing easily submerge weak target signals, severely limiting traditional single-photon systems under low signal-to-background ratios. To address this, this paper proposes an urban-oriented detection strategy based on a free-running single-photon array, and designs a dual-optimized pulse position modulation laser detection and range image enhancement algorithm. By establishing temporal correlations via pulse sequence convolution, the algorithm effectively isolates weak UAV echoes from strong background clutter to break through detection limitations. Compared with the popular Markov correction method that often suppresses overlapping weak targets under strong reflections, the proposed method significantly improves small-target feature retention, successfully balancing background elimination and detection sensitivity. Field tests and quantitative evaluations demonstrate that the system reliably eliminates building clutter and achieves stable continuous tracking of weak UAV signals within 1.5 km, providing a highly robust and effective technical solution for urban low-altitude surveillance. Full article

Background/Objectives: Patellofemoral joint (PFJ) replacement is a bone-preserving option for isolated patellofemoral osteoarthritis; however, reported survivorship and failure patterns remain variable. This study evaluated implant survivorship, functional outcomes, reoperations, and failure mechanisms following PFJ replacement using standard second-generation implant systems, with or without patellar resurfacing. Methods: We retrospectively reviewed a consecutive cohort of 39 patients (48 knees) who underwent PFJ replacement for isolated patellofemoral osteoarthritis between 2011 and 2021. Median age at surgery was 59 years, and median body mass index (BMI) was 31 kg/m². Median follow-up for clinical and revision surveillance was 9 years (IQR 8–10). Functional outcomes were assessed using the Oxford Knee Score (OKS) and SF-12 Physical and Mental Component Scores (PCS and MCS). Implant survivorship was analyzed using Kaplan–Meier methodology, with conversion to total knee arthroplasty (TKA) as the endpoint. Statistical analyses were primarily descriptive and exploratory because only five TKA revisions occurred. Results: Median OKS improved from 19 (IQR 16–24) preoperatively to 36 (IQR 24–42) at the latest follow-up, with a median paired improvement of 17 points. SF-12 PCS improved from 25 to 47, and SF-12 MCS from 36 to 55. Eight knees (16.7%) underwent non-revision reoperation, and five knees (10.4%) underwent conversion to TKA. All TKA revisions were performed for the progression of tibiofemoral osteoarthritis. Kaplan–Meier survivorship free from TKA revision was 89.6% at 9 years (95% CI 76.8–95.5). No clear difference in TKA-free survivorship was detected between resurfaced and non-resurfaced knees. Conclusions: PFJ replacement demonstrated substantial functional improvement and mid- to long-term survivorship comparable to published registry ranges in a selected cohort with isolated patellofemoral osteoarthritis. TKA revision was uncommon and was attributable to the progression of tibiofemoral osteoarthritis. Because of the retrospective design, small cohort size, bilateral cases, and limited number of revision events, subgroup and risk-factor analyses should be interpreted as exploratory. Full article

The emerging potential of low-Earth-orbit (LEO) satellite-based Positioning, Navigation, and Timing services has increased the need for real-time, stable, and accurate orbit determination techniques. Here, we propose a method for estimating sub-meter-level LEO satellite orbits using Global Navigation Satellite System (GNSS) code pseudorange observations. To mitigate ionospheric delay, a dual-frequency ionosphere-free combination was applied, while code-carrier smoothing was employed to reduce code observation noise. A satellite weighting model based on Signal-in-Space Range Error was developed to reflect the orbit and clock error characteristics of different GNSS, and a robust weighting scheme was applied to alleviate the impact of observation outliers. Further, Galileo High Accuracy Service corrections compensated for orbit, clock and code bias errors. The algorithm was validated using the GNSS observation data collected from the Sentinel-6A satellite on 10 August 2023. Each successively applied technique gradually improved orbit determination accuracy, achieving up to a 51% reduction in 3D root mean square error (RMSE). The final RMSE values in the radial, along-track, cross-track, and 3D components were 39.4, 18.8, 23.5, and 49.6 cm, respectively. Temporal analysis showed no distinct periodicity in orbit errors and no significant correlation with satellite visibility or ground track. Full article

Background/Objectives: Automated insulin delivery (AID) systems have improved the management of type 1 diabetes (T1D), but exercise and nutrition remain challenging because they rapidly alter glucose flux, substrate oxidation, hepatic glucose output, insulin requirements, and fuel availability. This narrative review aimed to synthesize current evidence on the interaction between AID systems, physical activity, and nutritional strategies from a metabolism-oriented perspective. Methods: A narrative bibliographic approach was used to integrate evidence from clinical trials, observational studies, technical studies, consensus statements, and reviews involving people with T1D across different life stages, including pediatric, adolescent, adult, and pregnancy-related contexts, when available. The review focused on AID systems, exercise physiology, nutritional strategies, meal announcement, bolus adjustment, dual-hormone systems, metabolic biomarkers, and emerging metabolomic approaches. Results: AID systems generally improve time in range and reduce hypoglycemia across several user groups, although most exercise- and nutrition-specific evidence comes from adult and pediatric/adolescent cohorts rather than pregnancy-specific exercise studies. Exercise-related glucose responses remain highly dependent on user input, exercise modality, insulin on board, meal timing, and metabolic state. Planned exercise announcement, prandial bolus reduction before postprandial activity, and individualized carbohydrate intake remain key strategies. Biomarkers such as lactate, ketone bodies, non-esterified fatty acids, and counter-regulatory hormones may help explain interindividual variability and support future personalization. Conclusions: Nutrition and exercise management in AID users should be interpreted as a dynamic metabolic interface among exogenous insulin, endogenous counter-regulation, substrate availability, and algorithmic control. Emerging approaches, including activity sensors, adaptive algorithms, dual-hormone systems, digital twins, and metabolomics-informed personalization, may improve safety and reduce user burden, but several remain exploratory and require further validation in diverse free-living conditions. Full article

This study investigated the valorization of agro-industrial by-products, namely Nigella sativa seed meal (BCSM) and whey, as functional ingredients to improve the quality of rice-based gluten-free bread. A Response Surface Methodology (RSM) approach was applied to optimize formulation parameters and evaluate their effects on physicochemical, rheological, nutritional, and sensory properties. The optimized formulations showed distinct performance profiles depending on the rice matrix and ingredient balance. The optimized brown rice bread (OBRB), characterized by the highest BCSM incorporation (10 g), showed the most relevant functional and nutritional improvements, including increased dietary fiber, enhanced antioxidant activity, and reduced hardness and chewiness compared with the corresponding control. In contrast, the optimized red rice bread (ORRB), characterized by low BCSM content and higher whey incorporation, mainly contributed to improved specific volume and crumb structure. Rheological analysis revealed distinct structural behaviors, with BCSM contributing to a more rigid and structured matrix, while whey promoted a softer and more compliant dough system. Sensory evaluation confirmed that the incorporation of these by-products did not negatively affect acceptability, with overall acceptability scores ranging between 5 and 6. Overall, these results indicate that OBRB was the most promising formulation for functional enrichment, whereas ORRB was mainly associated with structural optimization. This study demonstrates that BCSM and whey can be strategically used as formulation-dependent ingredients for developing nutritionally enhanced and structurally improved gluten-free bread, contributing to the sustainable valorization of food industry by-products. Full article

Background: The click-evoked Auditory Brainstem Response (ABR) is the gold standard electrophysiological tool for assessing auditory pathway integrity in infants and young children. As normative data are inherently equipment-specific, the absence of pediatric reference values for the NeuroAudio system (Neurosoft, Ivanovo, Russia) represents a significant gap in clinical practice, given that existing normative datasets for this system are restricted to adult populations. Objective: To establish normative data for click ABR recorded with the NeuroAudio system in children under three years of age, stratified by age group according to auditory maturation patterns. Methods: A prospective, cross-sectional study was conducted at the Electrophysiology Laboratory of the Department of Speech Therapy, Paulista School of Medicine, Federal University of São Paulo (UNIFESP/EPM), under the approval of the Research Ethics Committee (protocol 7.939.564). A total of 203 children (121 males, 82 females; age range: 2 weeks to 36 months) with confirmed normal peripheral auditory function were included. Click stimuli (0.1 ms, rarefaction polarity) were delivered monaurally via ER-3A insert earphones at 80 dB nHL and a repetition rate of 19.3/s. Two average runs of 2000 artifact-free sweeps were recorded per ear. Absolute latencies of waves I, III, and V, interpeak intervals I–III, III–V, and I–V, and amplitudes of waves I and V were analyzed. Results: Statistical modeling supported the consolidation of 12 initial age bins into three clinically and statistically validated categories: 0–3, 4–12, and 13–36 months. Wave I latency remained stable across age groups, whereas waves III and V and all interpeak intervals showed progressive shortening with increasing age. Wave V amplitude increased progressively with age, while wave I amplitude remained unchanged. Females presented shorter latencies than males for waves III and V and for all interpeak intervals. The right ear exhibited a shorter III–V interpeak interval than the left ear, with a significant ear × age interaction indicating that this asymmetry is modulated during early maturation. Age, sex, and ear-stratified normative values (two SD and three SD reference limits) are reported. Conclusion: This study provides the first pediatric normative dataset for click-evoked ABR acquired with the NeuroAudio system in children under three years of age. The proposed three age stratifications, together with sex- and ear-specific reference values for the III–V interpeak interval, offer a clinically actionable framework for the accurate interpretation of pediatric ABR recordings and for the early identification of auditory pathway abnormalities. Full article

Background: Circulating cell-free DNA (cfDNA) enables minimally invasive tumour genomic profiling, yet simultaneous interrogation of mutations and DNA methylation remains limited by assay complexity and input constraints. Methods: Here, we evaluate the Agilent Avida Duo system, a single workflow integrating high-sensitivity mutation detection with targeted DNA methylation analysis. We analysed 21 stage III and IV melanoma patient samples. Results: The Avida Duo mutation assay detected mutant allele frequencies (MAFs) down to 0.05% and identified tumour-associated mutations in all melanoma patients, including within GC-rich regions such as the TERT promoter. Optimisation of the Avida Duo mutation workflow, using TapeStation-quantified cfDNA and reduced amplification cycles, improved library consistency without compromising sensitivity. Methylation profiling of the melanoma baseline cohort with the Avida Duo methylation panel showed high concordance with QIAseq targeted methylation results, with the mean cfDNA fraction methylation ranging from 0.051–0.079 in most patients and reaching 0.249 in the patient with the highest ctDNA burden (MAFs up to 35.4%). Conclusions: Our findings demonstrate that the Avida Duo workflow enables simultaneous, high-resolution detection of mutation and methylation profiles from a single cfDNA sample, streamlining processing and enhancing molecular insight for clinical and translational applications. Full article

Background: Iodine-based antimicrobial systems remain highly attractive due to their broad-spectrum activity; however, the clinical application of free iodine is limited by its instability and cytotoxicity. This study aimed to develop polyethylene glycol (PEG)-based hydrophilic ointment formulations containing a dextrin/polyvinyl alcohol/iodine complex (D/PVA/I) and to evaluate their physicochemical properties, antimicrobial activity, and cytotoxicity. Methods: Hydrophilic ointment formulations containing 2.5%, 5.0%, and 10.0% D/PVA/I were prepared using a PEG-based matrix composed of PEG 4000, PEG 400, and glycerol. Physicochemical characterization included organoleptic evaluation, pH measurement, rheological analysis, and UV–visible (Ultraviolet–visible) spectroscopy. Antimicrobial activity was assessed using agar diffusion and minimum bactericidal concentration (MBC) assays against Staphylococcus aureus, Escherichia coli, Enterococcus hirae, and Pseudomonas aeruginosa. Cytotoxicity was evaluated in Madin–Darby Canine Kidney (MDCK) cells using the MTT assay. Results: All formulations exhibited homogeneous semisolid structure and physiologically acceptable pH values (4.94–5.45). Rheological analysis demonstrated non-Newtonian pseudoplastic (shear-thinning) behavior. The flow behavior index (n) ranged from 0.03 to 0.33 according to the Ostwald–de Waele model, confirming shear-thinning characteristics, while viscosity increased with increasing D/PVA/I concentration. UV–visible spectroscopy confirmed the presence of triiodide ions (I_3⁻), characterized by absorption maxima at approximately 287 and 350 nm, indicating preservation of active iodine species within the PEG matrix, while placebo (blank) formulation analysis confirmed the absence of corresponding absorption bands, demonstrating that the PEG-based matrix does not contribute to the characteristic spectral features. The formulations demonstrated broad-spectrum antimicrobial activity, with MBC values ranging from 0.01 to 0.02 µg/mL. Cytotoxicity studies revealed moderate toxicity of the D/PVA/I complex (CC₅₀ = 0.82%) (50% cytotoxic concentration (CC₅₀) and significantly lower toxicity of the PEG-based ointment base (CC₅₀ = 18.38%). Conclusions: The developed PEG-based hydrophilic ointment formulations containing the D/PVA/I complex demonstrated favorable physicochemical characteristics, stability of iodine species, pronounced antimicrobial activity, and acceptable cytotoxicity profiles. These findings highlight the potential for the developed systems to be promising topical antimicrobial formulations. Full article

Introduction: Aquatic chemical pollution is among the most worrying threats to ecosystem health. There is an ever-increasing variety of pollutant substances detected across the source-to-sea continuum, causing loss of biodiversity and ecological disequilibrium. Achieving cleaner and healthier systems relies on carrying out sustained, cost-effective, diagnosis and aquatic effects monitoring, within the adaptive management cycle. The available methods are, however, cumbersome, which creates a clear need for innovative expeditious approaches for low-cost surveillance monitoring. In the last decade, Raman Spectroscopy (RS) has gained wide recognition for application to biological questions, for its ability to uncover the complexity of molecules and their interactions. Various fields, from pharmacology to disease diagnosis and prognosis, have suffered an innovation revolution through the application of RS. In this technique inelastic light scattering of a small part of photons of an incident electromagnetic monochromatic light beam (ranging from near-infrared to visible or ultraviolet) is caused by the molecular vibration of chemical bonds. This results in shifts in energy, which indicate discrete vibrational modes of polarisable molecules, providing qualitative and quantitative assessments of the chemical composition and molecular structure of the sample. The technique shows high sensitivity, no need for sample preparation and the possibility of use in non-invasive and label-free analysis. Objective: The aim of this work is to present and discuss evidence about the application of Raman Spectroscopy (RS) to environmental diagnosis and aquatic effect monitoring of pollution. Methodology: The technique was applied to different biological models, i.e., diatoms, zebrafish embryos and larvae and freshwater snails. Quality assessments with diatoms were tested in environmental monitoring, while assessments with other models were done upon exposure to metals and organic contaminants. Results and conclusions: The Raman spectra obtained from the samples analysed comprised bands detected within the 800 to 2000 cm⁻¹ wavenumber range. These were related to bond vibrations of carbohydrates, DNA phosphate groups, proteins or CH, NH and OH stretching in lipids and proteins. Data analysis using chemometric methods clearly distinguished pollutant exposure from control sites or treatments, pointing out the potential for surveyance monitoring. The next steps include the comparison with other sensitive methods (e.g., locomotion and avoidance behaviours, omics methods) to assess efficiency and bring further mechanistic understanding. Full article