Search Results (3,883)

Scholars have long shown that post-separation abuse continues through legal channels and that legal institutions often reinforce existing social relations. Nevertheless, little is known about how abused mothers’ legal experiences shape their understanding of legality and how this dynamic may function to perpetuate coercive control. Drawing on in-depth interviews with 32 Israeli mothers co-parenting with abusive ex-partners, this study offers a phenomenological account of how post-separation abused mothers experience family law proceedings, based on a feminist imperative to bring their voices to center stage. The analysis reveals a dialectical legal consciousness comprising three interconnected orientations—characterized by internal contradictions and tensions that paradoxically serve to maintain rather than disrupt existing power relations: Institutional Trust and Disillusionment in the law’s protective promise, Institutional Asymmetry as experienced from the abused mothers’ perspective, and Recognizing Entrapment—the realization that legal processes reproduce the very dynamics they sought to escape. Abused mothers thus describe a paradoxical relationship with the law of both needing and distrusting a system that mandates continued contact with their abusers. Caught in a second-order abusive relationship, they feel compelled to comply with processes they perceive as harmful. We term this Entrapped Legal Consciousness—a form of legal subjectivity shaped by institutional norms that reconfigure resistance and reinscribe coercive control. This study offers empirical and theoretical insight into how legality may become a mechanism for cultivating continued control. Full article

Background/Objectives: CLIFAHDD syndrome (OMIM # 616266) is a rare neurodevelopmental disorder caused by mutations in the NALCN gene. It is characterized by hypotonia, developmental delay, and congenital contractures of the limbs and face. We report a 33-year-old Italian woman with a mild form of CLIFAHDD who exhibited early-onset language difficulties and mild intellectual disability and later developed gait and balance impairments in adulthood. Methods and Results: Whole Exome Sequencing (WES) identified a novel missense variant c.1514A>T; p.(Lys505Met) in the NALCN gene. The allele frequency of this variant is not detected (MAF = 0.0), the variant is classified as likely pathogenic according to ACMG criteria, and predicted to be probably damaging by PolyPhen-2. It affects a critical residue within the second pore-forming domain of the NALCN channel, potentially altering lipid interactions and channel regulation. Sanger sequencing and segregation analysis confirmed the variant to be heterozygous and de novo. Conclusions: The patient’s milder symptoms and later onset, compared to severe pediatric cases, suggest that the clinical spectrum of CLIFAHDD syndrome may be broader than previously recognized. These findings underscore the potential influence of mutation location on disease presentation and severity. Full article

The prediction of thin-bedded, favorable sand bodies within the Triassic Baikouquan Formation fan delta on the western slope of the Mahu Sag is challenging due to their strong spatial heterogeneity. To address this, we propose an integrated workflow that synergizes seismic sedimentology with geologically constrained seismic inversion. This study leverages well logging, core data, and 3D seismic surveys. Initially, seismic attribute analysis and stratal slicing were employed to delineate sedimentary microfacies, revealing that the fan delta front subfacies comprises subaqueous distributary channels, interdistributary bays, and distal bars. Subsequently, the planform distribution of these microfacies served as a critical constraint for the Seismic Waveform Indicative Inversion (SWII), effectively enhancing the resolution for thin sand body identification. The results demonstrate the following: (1). Two NW-SE trending subaqueous distributary channel systems, converging near the BAI65 well, form the primary reservoirs. (2). The SWII, optimized by our workflow, successfully predicts high-quality sand bodies with a cumulative area of 159.2 km², primarily located in the MAXI1, AIHU10, and AICAN1 well areas, as well as west of the MA18 well. This study highlights the value of integrating sedimentary facies boundaries as a geological constraint in seismic inversion, providing a more reliable method for predicting heterogeneous thin sand bodies and delineating future exploration targets in the Mahu Sag. Full article

Quantum information quantities, such as mutual information and entropies, are essential for characterizing quantum systems and protocols in quantum information science. In this contribution, we identify types of information measures based on generalized divergences and prove their invariance under local isometric or unitary transformations. Leveraging the reversal channel for local isometries together with the data-processing inequality, we establish invariance for information quantities used in both asymptotic and one-shot regimes without relying on the specific functional form of the underlying divergence. These invariances can be applied to improve the computation of such information quantities or optimize protocols and their output states, whose performance is determined by some invariant measure. Our results improve the capability to characterize and compute many operationally relevant information measures with application across the field of quantum information processing. Full article

Aluminum alloy surface microstructures possess functional characteristics such as hydrophilicity/hydrophobicity and anti-icing and have important applications in fields such as aerospace and power systems. In order to improve the filling quality of the microstructure and verify the anti-icing property of the microstructure, this work develops a scheme for achieving large-area hot embossing of anti-icing functional microstructures based on a multi-arc ion-plating mold. Compared with conventional steel, the hardness of the PVD-coated steel increases by 44.7%, the friction coefficient decreases by 66.2%, and the wear resistance is significantly enhanced. The PVD-coated punch-assisted embossing could significantly improve filling properties. While the embossing temperature is 300 °C, the PVD-coated punch-assisted embossing can ensure the complete filling of the micro-array channels. In contrast, under-filling defects occur in conventional hot embossing. Then, a large-area micro-channel specimen of 100 cm² was precisely formed without warping, and the average surface roughness Ra was better than 0.8 µm. The maximum freezing fraction of the micro-array channel was reduced by about 53.2% compared with the planar, and the complete freezing time was delayed by 193.3%. The main reason is that the air layer trapped by the hydrophobic structures hinders heat loss at the solid–liquid interface. Full article

Background/Objectives: This article discusses the clinical–surgical relevance of vascular anatomical variations, such as fenestrations—the division of a vessel into multiple channels that subsequently rejoin distally. Although rare in peripheral veins, these variations, which originate from the incomplete condensation of the embryonic capillary plexus, can predispose thrombosis and necessitate preoperative recognition to avert complications during routine procedures. This study aims to report a rare case of dual origin and double fenestration of the cephalic vein. Methods: During a cadaveric dissection, a variation of the cephalic vein was identified. Results: In this case, an origin of the cephalic vein was observed arising from the dorsal venous network of the hand. It exhibited a double fenestration in the forearm, where a branch of the medial cutaneous nerve of the forearm perforated it before draining into the brachial vein. The second, a proximal origin, arose from the convergence of two tributaries—one originating from the subcutaneous tissue lateral to the brachial muscle and the other from the biceps brachii muscle, forming a single trunk that drained into the subclavian vein. Conclusions: This rare variation of the cephalic vein (dual origin and fenestration) carries significant hemodynamic implications, including an increased risk of turbulence and thrombosis. The atypical anatomical relationship between the nerve and the fenestrated vein also heightens the potential for iatrogenic injuries. In-depth knowledge of such anomalies is crucial for healthcare professionals to minimize complications and optimize the success of procedures like venous access and arteriovenous fistulas, ultimately ensuring patient safety. Full article

Graph Neural Networks (GNNs) capture complex information in graph-structured data by integrating node features with iterative updates of graph topology. However, they inherently rely on the homophily assumption—that nodes of the same class tend to form edges. In contrast, real-world networks often exhibit heterophilous structures, where edges are frequently formed between nodes of different classes. Consequently, conventional GNNs, which apply uniform smoothing over all nodes, may inadvertently aggregate both task-relevant and task-irrelevant information, leading to suboptimal performance on heterophilous graphs. In this work, we propose TRed-GNN, a novel end-to-end GNN architecture designed to enhance both the performance and robustness of node classification on heterophilous graphs. The proposed approach decomposes the original graph into a task-relevant subgraph and a task-irrelevant subgraph and employs a dual-channel mechanism to independently aggregate features from each topology. To mitigate the interference of task-irrelevant information, we introduce a reverse process mechanism that, without compromising the main task, extracts potentially useful information from the task-irrelevant subgraph while filtering out noise, thereby improving generalization and resilience to perturbations. Theoretical analysis and extensive experiments on multiple real-world datasets demonstrate that TRed-GNN not only achieves superior classification performance compared to existing methods on most benchmarks, but also exhibits strong adaptability and stability under graph structural perturbations and over-smoothing scenarios. Full article

Searching anode materials is an important task for the development of sodium-ion batteries. In this regard, bronze-phase titanium dioxide, TiO₂(B), has been considered as one of the promising materials, owing to its crystal structure with open channels and voids facilitating Na⁺ diffusion and storage. However, the electrochemical de-/sodiation mechanism of TiO₂(B) has not been clearly comprehended, and further experiments are required. Herein, in situ and ex situ observations by a combination of X-ray photoelectron spectroscopy, X-ray diffraction, Raman spectroscopy, gas chromatography–mass spectrometry was used to provide additional insights into the electrochemical reaction scenario of bronze-phase TiO₂ in Na-ion batteries. The findings reveal that de-/sodiation of TiO₂(B) occurs through a reversible intercalation reaction and without the involvement of the conversion reaction (no metallic titanium is formed and no oxygen is released). At the same time, upon the first Na⁺ uptake process, crystalline TiO₂(B) becomes partially amorphous, but is still driven by the Ti⁴⁺/Ti³⁺ redox couple. Importantly, TiO₂(B) has pseudocapacitive electrochemical behavior during de-/sodiation based on a quantitative analysis of the cyclic voltammetry data. The results obtained in this study complement existing insights into the sodium storage mechanisms of TiO₂(B) and provide useful knowledge for further improving its anode performance for SIBs application. Full article

Background/Objectives: Vestibulodynia is the prevalent form of vulvodynia, causing burning, irritation, rawness, and dyspareunia sensations. This sensory abnormality suggests sensitization to neuropathic pain. Methods: This was a randomized double-blind trial involving patients who applied a 5% cannabidiol gel with myrcene or a placebo to their vulvar vestibule for 60 days, assessing changes in dyspareunia, pain, and vestibular cotton swab test scores on a 0–10-point VAS scale. Results: This study enrolled 40 women, with 20 in the active treatment group and 20 in the placebo group. All symptoms improved in both groups, but the active treatment group showed a greater reduction in VAS scores for pain and swab tests. However, dyspareunia improved significantly more in the active treatment group. Conclusions: Cannabidiol’s positive effects on vestibulodynia patients can be attributed to its antinociceptive and anti-inflammatory properties. It desensitizes transient vanilloid receptor potential channels subtype 1, which are found in peripheral C-fiber nociceptors and mast cells. The results also suggest that myrcene, a terpene found in cannabis, can inhibit peripheral sensitization exerted by cannabidiol. Full article

Mutation T226R in the Kv1.1 α-subunit of voltage-gated potassium Kv1 channels is associated with episodic ataxia type 1, severe neuromyotonia, and epilepsy. In vitro, this mutation was reported to considerably distort the functioning of homotetrameric channels Kv1.1; however, in the brain, Kv1.1 α-subunits form heterochannels predominantly associating with Kv1.2 α-subunits. Using the patch-clamp technique, fluorescent and Förster resonance energy transfer confocal microscopy, we revealed that heterochannels Kv(1.1(T226R)-1.2)₂ formed by concatemers Kv1.1(T226R)-Kv1.2 in Neuro-2a cells have significantly slower activation and deactivation rates, and their activation occurs at a much less negative membrane potential compared to channels Kv(1.1-1.2)₂ formed by concatemers Kv1.1-Kv1.2. This mutation does not noticeably affect the formation of complexes between α-subunits Kv1.1 and Kv1.2, but it does induce a delayed and possibly decreased presentation of heterochannels Kv(1.1(T226R)-1.2)₂ on the plasma membrane. At the same time, the T226R mutation has a much stronger negative effect on the membrane presentation of homotetrameric Kv1.1 channels. Since heterochannels Kv1.1-Kv1.2 but not homotetrameric channels Kv1.1 are present in the brain, the heterochannels bearing mutation T226R are most likely underlying the pathogenesis of the disease by decreasing the responsiveness of cells to mild membrane depolarization and, thus, increasing the excitability of neurons. Full article

This study focuses on a novel lightweight technology for manufacturing variable-axial fiber-reinforced polymer components. In the presented approach, channels following the load flow are implemented in an additively manufactured basic structure and impregnated continuous fiber bundles are pulled through these component-integrated cavities. Improved channel cross-section geometries to enhance the mechanical performance are proposed and evaluated. The hypothesis posits that increasing the surface area of the internal channels significantly reduces shear stresses between the polymer basic structure and the integrated continuous fiber composite. A series of experiments, including analytical, numerical, and microscopic analyses, were conducted to evaluate the mechanical properties of the composites formed, focusing on Young’s modulus and tensile strength. In addition, an important insight into the failure mechanism of the novel fiber composite is provided. The results demonstrate a clear correlation between the channel geometry and mechanical performance, indicating that optimized designs can effectively reduce shear stress, thus improving load-bearing capacities. The findings reveal that while fiber volume content influences the impregnation quality, an optimal balance must be achieved to enhance mechanical properties. This research contributes to the advancement of production technologies for lightweight components through additive manufacturing and the development of new types of composite materials applicable in various engineering fields. Full article

Integrated sensing and communication (ISAC) has emerged as a transformative technology for intelligent transportation systems. Index modulation (IM), recognized for its high robustness and energy efficiency (EE), has been successfully incorporated into ISAC systems. However, most existing IM-based ISAC schemes overlook the spatial multiplexing potential of millimeter-wave channels and remain confined to single-hop vehicle-to-vehicle (V2V) setups, failing to address the challenges of energy consumption and noise accumulation in real-world multi-hop V2V networks with complex road topologies. To bridge this gap, we propose a spatial scattering modulation-based ISAC (ISAC-SSM) scheme and introduce it to multi-hop V2V networks. The proposed scheme leverages the sensed positioning information to select maximum signal-to-noise ratio relay vehicles and employs a detect-amplify-and-forward (DAF) protocol to mitigate noise propagation, while utilizing sensed angle data for Doppler compensation to enhance communication reliability. At each hop, the transmitter modulates index bits on the angular-domain spatial directions of scattering clusters, achieving higher EE. We initially derive a closed-form bit error rate expression and Chernoff upper bound for the proposed DAF ISAC-SSM under multi-hop V2V networks. Both theoretical analyses and Monte Carlo simulations have been made and demonstrate the superiority of DAF ISAC-SSM over existing alternatives in terms of EE and error performance. Specifically, in a two-hop network with 12 scattering clusters, compared with DAF ISAC-conventional spatial multiplexing, DAF ISAC-maximum beamforming, and DAF ISAC-random beamforming, the proposed DAF ISAC-SSM scheme can achieve a coding gain of 1.5 dB, 2 dB, and 4 dB, respectively. Moreover, it shows robust performance with less than a 1.5 dB error degradation under 0.018 Doppler shifts, thereby verifying its superiority in practical vehicular environments. Full article

Predicting favorable reservoirs controlled by source-to-sink systems in rift basins is a current research focus. Using seismic, core, drilling, logging, and thin-section data, this paper systematically identifies fan types and their reservoir characteristics controlled by two boundary faults in the southern steep-slope zone of Wushi Sag, Beibuwan Basin, South China Sea. The analysis compares differences in (1) source–channel–margin–sink systems and (2) diagenetic facies, dividing the sink area into migratory and progradational fans. Results show that migratory fans are associated with denudation. Sediments migrate through wide, deep “V”-shaped valleys, forming fan deltas that are large in area but short in progradation. Lithology is dominated by fine sandstone with siltstone interbeds, reservoirs’ diagenetic evolution is weak, pores are mainly primary, and Type I–II reservoirs are developed. In contrast, progradational fans reflect weaker source area denudation, with sediments prograding through narrow, shallow “U”-shaped valleys. These form broom-shaped fan deltas that are small in area but long in progradation, with lithology dominated by fine sandstone interbedded with mudstone. Reservoirs show strong diagenetic evolution, well-developed secondary porosity, and Type II–III reservoirs. Reservoir prediction models indicate that high-quality migratory reservoirs are large, with excellent physical properties and oil-bearing capacity, mainly in fan stacking zones. High-quality progradational reservoirs are concentrated in the fan midsections, with strong cementation and secondary porosity. These findings provide a theoretical basis for reservoir prediction and oil and gas exploration in the southern steep-slope zone of Wushi Sag. Full article

Crude oil and grain, as two pivotal global commodities, exhibit significant price co-movement that profoundly affects national economic stability and food security. From the perspective of systems theory, the energy and grain markets do not exist in isolation but rather form a highly coupled complex system, characterized by nonlinear feedback, cross-market risk contagion, and cascading effects. This study systematically investigates the transmission mechanisms from international crude oil prices to the domestic prices of Chinese four major grains, employing the DY spillover index, Vector Error Correction Model (VECM), and a mediation effect framework. The empirical findings reveal three key insights. First, rising international crude oil prices significantly strengthen the pass-through of global grain prices to domestic markets, while simultaneously weakening the effectiveness of domestic price stabilization policies. Second, higher crude oil prices amplify international-to-domestic price spillovers by increasing maritime freight costs, a key channel in global grain trade logistics. Third, elevated oil prices stimulate demand for renewable biofuels, including biodiesel and ethanol, thereby boosting international demand for corn and soybeans and intensifying the transmission of price fluctuations in these commodities to the domestic market. These findings reveal the key pathways through which shocks in the energy market affect food security and highlight the necessity of studying the “energy–food” coupling mechanism within a systems framework, enabling a more comprehensive understanding of cross-market risk transmission. Full article

Microphysiological systems (MPSs) have emerged as alternatives to animal testing in drug development, following the FDA Modernization Act 2.0. Double-layer channel-type MPS chips with porous membranes are widely used for modeling various organs, including the intestines, blood–brain barrier, renal tubules, and lungs. However, these chips faced challenges owing to optical interference caused by light scattering from the porous membrane, which hinders cell observation. Trans-epithelial electrical resistance (TEER) measurement offers a non-invasive method for assessing barrier integrity in these chips. However, existing electrode-integrated MPS chips for TEER measurement have non-uniform current densities, leading to compromised measurement accuracy. Additionally, chips made from polydimethylsiloxane have been associated with drug absorption issues. This study developed an electrode-integrated MPS chip for TEER measurement with a uniform current distribution and minimal drug absorption. Through a finite element method simulation, electrode patterns were optimized and incorporated into a polyethylene terephthalate (PET)-based chip. The device was fabricated by laminating PET films, porous membranes, and patterned gold electrodes. The chip’s performance was evaluated using a perfused Caco-2 intestinal model. TEER levels increased and peaked on day 5 when cells formed a monolayer, and then they decreased with the development of villi-like structures. Concurrently, capacitance increased, indicating microvilli formation. Exposure to staurosporine resulted in a dose-dependent reduction in TEER, which was validated by immunostaining, indicating a disruption of the tight junction. This study presents a TEER measurement MPS platform with a uniform current density and reduced drug absorption, thereby enhancing TEER measurement reliability. This system effectively monitors barrier integrity and drug responses, demonstrating its potential for non-animal drug-testing applications. Full article