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Search Results (6,046)

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25 pages, 953 KiB  
Article
Command Redefined: Neural-Adaptive Leadership in the Age of Autonomous Intelligence
by Raul Ionuț Riti, Claudiu Ioan Abrudan, Laura Bacali and Nicolae Bâlc
AI 2025, 6(8), 176; https://doi.org/10.3390/ai6080176 (registering DOI) - 1 Aug 2025
Abstract
Artificial intelligence has taken a seat at the executive table and is threatening the fact that human beings are the only ones who should be in a position of power. This article gives conjectures on the future of leadership in which managers will [...] Read more.
Artificial intelligence has taken a seat at the executive table and is threatening the fact that human beings are the only ones who should be in a position of power. This article gives conjectures on the future of leadership in which managers will collaborate with learning algorithms in the Neural Adaptive Artificial Intelligence Leadership Model, which is informed by the transformational literature on leadership and socio-technical systems, as well as the literature on algorithmic governance. We assessed the model with thirty in-depth interviews, system-level traces of behavior, and a verified survey, and we explored six hypotheses that relate to algorithmic delegation and ethical oversight, as well as human judgment versus machine insight in terms of agility and performance. We discovered that decisions are made quicker, change is more effective, and interaction is more vivid where agile practices and good digital understanding exist, and statistical tests propose that human flexibility and definite governance augment those benefits as well. It is single-industry research that contains self-reported measures, which causes research to be limited to other industries that contain more objective measures. Practitioners are provided with a practical playbook on how to make algorithmic jobs meaningful, introduce moral fail-safes, and build learning feedback to ensure people and machines are kept in line. Socially, the practice is capable of minimizing bias and establishing inclusion by visualizing accountability in the code and practice. Filling the gap between the theory of leadership and the reality of algorithms, the study provides a model of intelligent systems leading in organizations that can be reproduced. Full article
(This article belongs to the Section AI Systems: Theory and Applications)
45 pages, 10039 KiB  
Article
Design of an Interactive System by Combining Affective Computing Technology with Music for Stress Relief
by Chao-Ming Wang and Ching-Hsuan Lin
Electronics 2025, 14(15), 3087; https://doi.org/10.3390/electronics14153087 (registering DOI) - 1 Aug 2025
Abstract
In response to the stress commonly experienced by young people in high-pressure daily environments, a music-based stress-relief interactive system was developed by integrating music-assisted care with emotion-sensing technology. The design principles of the system were established through a literature review on stress, music [...] Read more.
In response to the stress commonly experienced by young people in high-pressure daily environments, a music-based stress-relief interactive system was developed by integrating music-assisted care with emotion-sensing technology. The design principles of the system were established through a literature review on stress, music listening, emotion detection, and interactive devices. A prototype was created accordingly and refined through interviews with four experts and eleven users participating in a preliminary experiment. The system is grounded in a four-stage guided imagery and music framework, along with a static activity model focused on relaxation-based stress management. Emotion detection was achieved using a wearable EEG device (NeuroSky’s MindWave Mobile device) and a two-dimensional emotion model, and the emotional states were translated into visual representations using seasonal and weather metaphors. A formal experiment involving 52 users was conducted. The system was evaluated, and its effectiveness confirmed, through user interviews and questionnaire surveys, with statistical analysis conducted using SPSS 26 and AMOS 23. The findings reveal that: (1) integrating emotion sensing with music listening creates a novel and engaging interactive experience; (2) emotional states can be effectively visualized using nature-inspired metaphors, enhancing user immersion and understanding; and (3) the combination of music listening, guided imagery, and real-time emotional feedback successfully promotes emotional relaxation and increases self-awareness. Full article
(This article belongs to the Special Issue New Trends in Human-Computer Interactions for Smart Devices)
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24 pages, 23817 KiB  
Article
Dual-Path Adversarial Denoising Network Based on UNet
by Jinchi Yu, Yu Zhou, Mingchen Sun and Dadong Wang
Sensors 2025, 25(15), 4751; https://doi.org/10.3390/s25154751 (registering DOI) - 1 Aug 2025
Abstract
Digital image quality is crucial for reliable analysis in applications such as medical imaging, satellite remote sensing, and video surveillance. However, traditional denoising methods struggle to balance noise removal with detail preservation and lack adaptability to various types of noise. We propose a [...] Read more.
Digital image quality is crucial for reliable analysis in applications such as medical imaging, satellite remote sensing, and video surveillance. However, traditional denoising methods struggle to balance noise removal with detail preservation and lack adaptability to various types of noise. We propose a novel three-module architecture for image denoising, comprising a generator, a dual-path-UNet-based denoiser, and a discriminator. The generator creates synthetic noise patterns to augment training data, while the dual-path-UNet denoiser uses multiple receptive field modules to preserve fine details and dense feature fusion to maintain global structural integrity. The discriminator provides adversarial feedback to enhance denoising performance. This dual-path adversarial training mechanism addresses the limitations of traditional methods by simultaneously capturing both local details and global structures. Experiments on the SIDD, DND, and PolyU datasets demonstrate superior performance. We compare our architecture with the latest state-of-the-art GAN variants through comprehensive qualitative and quantitative evaluations. These results confirm the effectiveness of noise removal with minimal loss of critical image details. The proposed architecture enhances image denoising capabilities in complex noise scenarios, providing a robust solution for applications that require high image fidelity. By enhancing adaptability to various types of noise while maintaining structural integrity, this method provides a versatile tool for image processing tasks that require preserving detail. Full article
(This article belongs to the Section Sensing and Imaging)
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20 pages, 3027 KiB  
Article
Evolutionary Game Analysis of Multi-Agent Synergistic Incentives Driving Green Energy Market Expansion
by Yanping Yang, Xuan Yu and Bojun Wang
Sustainability 2025, 17(15), 7002; https://doi.org/10.3390/su17157002 (registering DOI) - 1 Aug 2025
Abstract
Achieving the construction sector’s dual carbon objectives necessitates scaling green energy adoption in new residential buildings. The current literature critically overlooks four unresolved problems: oversimplified penalty mechanisms, ignoring escalating regulatory costs; static subsidies misaligned with market maturity evolution; systematic exclusion of innovation feedback [...] Read more.
Achieving the construction sector’s dual carbon objectives necessitates scaling green energy adoption in new residential buildings. The current literature critically overlooks four unresolved problems: oversimplified penalty mechanisms, ignoring escalating regulatory costs; static subsidies misaligned with market maturity evolution; systematic exclusion of innovation feedback from energy suppliers; and underexplored behavioral evolution of building owners. This study establishes a government–suppliers–owners evolutionary game framework with dynamically calibrated policies, simulated using MATLAB multi-scenario analysis. Novel findings demonstrate: (1) A dual-threshold penalty effect where excessive fines diminish policy returns due to regulatory costs, requiring dynamic calibration distinct from fixed-penalty approaches; (2) Market-maturity-phased subsidies increasing owner adoption probability by 30% through staged progression; (3) Energy suppliers’ cost-reducing innovations as pivotal feedback drivers resolving coordination failures, overlooked in prior tripartite models; (4) Owners’ adoption motivation shifts from short-term economic incentives to environmentally driven decisions under policy guidance. The framework resolves these gaps through integrated dynamic mechanisms, providing policymakers with evidence-based regulatory thresholds, energy suppliers with cost-reduction targets, and academia with replicable modeling tools. Full article
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22 pages, 1470 KiB  
Article
An NMPC-ECBF Framework for Dynamic Motion Planning and Execution in Vision-Based Human–Robot Collaboration
by Dianhao Zhang, Mien Van, Pantelis Sopasakis and Seán McLoone
Machines 2025, 13(8), 672; https://doi.org/10.3390/machines13080672 (registering DOI) - 1 Aug 2025
Abstract
To enable safe and effective human–robot collaboration (HRC) in smart manufacturing, it is critical to seamlessly integrate sensing, cognition, and prediction into the robot controller for real-time awareness, response, and communication inside a heterogeneous environment (robots, humans, and equipment). The proposed approach takes [...] Read more.
To enable safe and effective human–robot collaboration (HRC) in smart manufacturing, it is critical to seamlessly integrate sensing, cognition, and prediction into the robot controller for real-time awareness, response, and communication inside a heterogeneous environment (robots, humans, and equipment). The proposed approach takes advantage of the prediction capabilities of nonlinear model predictive control (NMPC) to execute safe path planning based on feedback from a vision system. To satisfy the requirements of real-time path planning, an embedded solver based on a penalty method is applied. However, due to tight sampling times, NMPC solutions are approximate; therefore, the safety of the system cannot be guaranteed. To address this, we formulate a novel safety-critical paradigm that uses an exponential control barrier function (ECBF) as a safety filter. Several common human–robot assembly subtasks have been integrated into a real-life HRC assembly task to validate the performance of the proposed controller and to investigate whether integrating human pose prediction can help with safe and efficient collaboration. The robot uses OptiTrack cameras for perception and dynamically generates collision-free trajectories to the predicted target interactive position. Results for a number of different configurations confirm the efficiency of the proposed motion planning and execution framework, with a 23.2% reduction in execution time achieved for the HRC task compared to an implementation without human motion prediction. Full article
(This article belongs to the Special Issue Visual Measurement and Intelligent Robotic Manufacturing)
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25 pages, 17227 KiB  
Article
Distributed Online Voltage Control with Feedback Delays Under Coupled Constraints for Distribution Networks
by Jinxuan Liu, Yanjian Peng, Xiren Zhang, Zhihao Ning and Dingzhong Fan
Technologies 2025, 13(8), 327; https://doi.org/10.3390/technologies13080327 (registering DOI) - 31 Jul 2025
Abstract
High penetration of photovoltaic (PV) generation presents new challenges for voltage regulation in distribution networks (DNs), primarily due to output intermittency and constrained reactive power capabilities. This paper introduces a distributed voltage control method leveraging reactive power compensation from PV inverters. Instead of [...] Read more.
High penetration of photovoltaic (PV) generation presents new challenges for voltage regulation in distribution networks (DNs), primarily due to output intermittency and constrained reactive power capabilities. This paper introduces a distributed voltage control method leveraging reactive power compensation from PV inverters. Instead of relying on centralized computation, the proposed method allows each inverter to make local decisions using real-time voltage measurements and delayed communication with neighboring PV nodes. To account for practical asynchronous communication and feedback delay, a Distributed Online Primal–Dual Push–Sum (DOPP) algorithm that integrates a fixed-step delay model into the push–sum coordination framework is developed. Through extensive case studies on a modified IEEE 123-bus system, it has been demonstrated that the proposed method maintains robust performance under both static and dynamic scenarios, even in the presence of fixed feedback delays. Specifically, in static scenarios, the proposed strategy rapidly eliminates voltage violations within 50–100 iterations, effectively regulating all nodal voltages into the acceptable range of [0.95, 1.05] p.u. even under feedback delays with a delay step of 10. In dynamic scenarios, the proposed strategy ensures 100% voltage compliance across all nodes, demonstrating superior voltage regulation and reactive power coordination performance over conventional droop and incremental control approaches. Full article
15 pages, 675 KiB  
Article
A Trusted Multi-Cloud Brokerage System for Validating Cloud Services Using Ranking Heuristics
by Rajganesh Nagarajan, Vinothiyalakshmi Palanichamy, Ramkumar Thirunavukarasu and J. Arun Pandian
Future Internet 2025, 17(8), 348; https://doi.org/10.3390/fi17080348 (registering DOI) - 31 Jul 2025
Abstract
Cloud computing offers a broad spectrum of services to users, particularly in multi-cloud environments where service-centric features are introduced to support users from multiple endpoints. To improve service availability and optimize the utilization of required services, cloud brokerage has been integrated into multi-cloud [...] Read more.
Cloud computing offers a broad spectrum of services to users, particularly in multi-cloud environments where service-centric features are introduced to support users from multiple endpoints. To improve service availability and optimize the utilization of required services, cloud brokerage has been integrated into multi-cloud systems. The primary objective of a cloud broker is to ensure the quality and outcomes of services offered to customers. However, traditional cloud brokers face limitations in measuring service trust, ensuring validity, and anticipating future enhancements of services across different cloud platforms. To address these challenges, the proposed intelligent cloud broker integrates an intelligence mechanism that enhances decision-making within a multi-cloud environment. This broker performs a comprehensive validation and verification of service trustworthiness by analyzing various trust factors, including service response time, sustainability, suitability, accuracy, transparency, interoperability, availability, reliability, stability, cost, throughput, efficiency, and scalability. Customer feedback is also incorporated to assess these trust factors prior to service recommendation. The proposed model calculates service ranking (SR) values for available cloud services and dynamically includes newly introduced services during the validation process by mapping them with existing entries in the Service Collection Repository (SCR). Performance evaluation using the Google cluster-usage traces dataset demonstrates that the ICB outperforms existing approaches such as the Clustering-Based Trust Degree Computation (CBTDC) algorithm and the Service Context-Aware QoS Prediction and Recommendation (SCAQPR) model. Results confirm that the ICB significantly enhances the effectiveness and reliability of cloud service recommendations for users. Full article
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26 pages, 5549 KiB  
Article
Intrusion Detection and Real-Time Adaptive Security in Medical IoT Using a Cyber-Physical System Design
by Faeiz Alserhani
Sensors 2025, 25(15), 4720; https://doi.org/10.3390/s25154720 (registering DOI) - 31 Jul 2025
Abstract
The increasing reliance on Medical Internet of Things (MIoT) devices introduces critical cybersecurity vulnerabilities, necessitating advanced, adaptive defense mechanisms. Recent cyber incidents—such as compromised critical care systems, modified therapeutic device outputs, and fraudulent clinical data inputs—demonstrate that these threats now directly impact life-critical [...] Read more.
The increasing reliance on Medical Internet of Things (MIoT) devices introduces critical cybersecurity vulnerabilities, necessitating advanced, adaptive defense mechanisms. Recent cyber incidents—such as compromised critical care systems, modified therapeutic device outputs, and fraudulent clinical data inputs—demonstrate that these threats now directly impact life-critical aspects of patient security. In this paper, we introduce a machine learning-enabled Cognitive Cyber-Physical System (ML-CCPS), which is designed to identify and respond to cyber threats in MIoT environments through a layered cognitive architecture. The system is constructed on a feedback-looped architecture integrating hybrid feature modeling, physical behavioral analysis, and Extreme Learning Machine (ELM)-based classification to provide adaptive access control, continuous monitoring, and reliable intrusion detection. ML-CCPS is capable of outperforming benchmark classifiers with an acceptable computational cost, as evidenced by its macro F1-score of 97.8% and an AUC of 99.1% when evaluated with the ToN-IoT dataset. Alongside classification accuracy, the framework has demonstrated reliable behaviour under noisy telemetry, maintained strong efficiency in resource-constrained settings, and scaled effectively with larger numbers of connected devices. Comparative evaluations, radar-style synthesis, and ablation studies further validate its effectiveness in real-time MIoT environments and its ability to detect novel attack types with high reliability. Full article
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11 pages, 262 KiB  
Article
Use of a Peer Equity Navigator Intervention to Increase Access to COVID-19 Vaccination Among African, Caribbean and Black Communities in Canada
by Josephine Etowa, Ilene Hyman and Ubabuko Unachukwu
Int. J. Environ. Res. Public Health 2025, 22(8), 1195; https://doi.org/10.3390/ijerph22081195 - 31 Jul 2025
Abstract
African, Caribbean, and Black (ACB) communities face increased COVID-19 morbidity and mortality, coupled with significant barriers to vaccine acceptance and uptake. Addressing these challenges requires innovative, multifaceted strategies. Peer-led interventions, grounded in critical health literacy (CHL) and critical racial literacy (CRL), and integrating [...] Read more.
African, Caribbean, and Black (ACB) communities face increased COVID-19 morbidity and mortality, coupled with significant barriers to vaccine acceptance and uptake. Addressing these challenges requires innovative, multifaceted strategies. Peer-led interventions, grounded in critical health literacy (CHL) and critical racial literacy (CRL), and integrating collaborative equity learning processes, can enhance community capacity, empowerment, and health outcomes, contributing to long-term health equity. This paper describes and presents the evaluative outcomes of a peer-led intervention aimed at enhancing COVID-19 vaccine confidence and acceptance. The Peer-Equity Navigator (PEN) intervention consisted of a specialized training curriculum grounded in CHL and CRL. Following training, PENs undertook a 5-month practicum in community or health settings, engaging in diverse outreach and educational activities to promote vaccine literacy in ACB communities. The evaluation utilized a modified Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) Framework, using quantitative and qualitative methods to collect data. Sources of data included tracking records with community feedback, and a PEN focus group, to assess program feasibility, outreach, and effectiveness. From 16 September 2022, to 28 January 2023, eight trained PENs conducted 56+ community events, reaching over 1500 community members. Both PENs and community members reported high engagement, endorsing peer-led, community-based approaches and increased vaccine literacy. The PEN approach proves feasible, acceptable, and effective in promoting positive health behaviors among ACB communities. This intervention has clear implications for health promotion practice, policy, and research in equity-deserving communities, including immigrants and refugees, who also face multiple and intersecting barriers to health information and care. Full article
16 pages, 628 KiB  
Article
Beyond the Bot: A Dual-Phase Framework for Evaluating AI Chatbot Simulations in Nursing Education
by Phillip Olla, Nadine Wodwaski and Taylor Long
Nurs. Rep. 2025, 15(8), 280; https://doi.org/10.3390/nursrep15080280 (registering DOI) - 31 Jul 2025
Abstract
Background/Objectives: The integration of AI chatbots in nursing education, particularly in simulation-based learning, is advancing rapidly. However, there is a lack of structured evaluation models, especially to assess AI-generated simulations. This article introduces the AI-Integrated Method for Simulation (AIMS) evaluation framework, a dual-phase [...] Read more.
Background/Objectives: The integration of AI chatbots in nursing education, particularly in simulation-based learning, is advancing rapidly. However, there is a lack of structured evaluation models, especially to assess AI-generated simulations. This article introduces the AI-Integrated Method for Simulation (AIMS) evaluation framework, a dual-phase evaluation framework adapted from the FAITA model, designed to evaluate both prompt design and chatbot performance in the context of nursing education. Methods: This simulation-based study explored the application of an AI chatbot in an emergency planning course. The AIMS framework was developed and applied, consisting of six prompt-level domains (Phase 1) and eight performance criteria (Phase 2). These domains were selected based on current best practices in instructional design, simulation fidelity, and emerging AI evaluation literature. To assess the chatbots educational utility, the study employed a scoring rubric for each phase and incorporated a structured feedback loop to refine both prompt design and chatbox interaction. To demonstrate the framework’s practical application, the researchers configured an AI tool referred to in this study as “Eval-Bot v1”, built using OpenAI’s GPT-4.0, to apply Phase 1 scoring criteria to a real simulation prompt. Insights from this analysis were then used to anticipate Phase 2 performance and identify areas for improvement. Participants (three individuals)—all experienced healthcare educators and advanced practice nurses with expertise in clinical decision-making and simulation-based teaching—reviewed the prompt and Eval-Bot’s score to triangulate findings. Results: Simulated evaluations revealed clear strengths in the prompt alignment with course objectives and its capacity to foster interactive learning. Participants noted that the AI chatbot supported engagement and maintained appropriate pacing, particularly in scenarios involving emergency planning decision-making. However, challenges emerged in areas related to personalization and inclusivity. While the chatbot responded consistently to general queries, it struggled to adapt tone, complexity and content to reflect diverse learner needs or cultural nuances. To support replication and refinement, a sample scoring rubric and simulation prompt template are provided. When evaluated using the Eval-Bot tool, moderate concerns were flagged regarding safety prompts and inclusive language, particularly in how the chatbot navigated sensitive decision points. These gaps were linked to predicted performance issues in Phase 2 domains such as dialog control, equity, and user reassurance. Based on these findings, revised prompt strategies were developed to improve contextual sensitivity, promote inclusivity, and strengthen ethical guidance within chatbot-led simulations. Conclusions: The AIMS evaluation framework provides a practical and replicable approach for evaluating the use of AI chatbots in simulation-based education. By offering structured criteria for both prompt design and chatbot performance, the model supports instructional designers, simulation specialists, and developers in identifying areas of strength and improvement. The findings underscore the importance of intentional design, safety monitoring, and inclusive language when integrating AI into nursing and health education. As AI tools become more embedded in learning environments, this framework offers a thoughtful starting point for ensuring they are applied ethically, effectively, and with learner diversity in mind. Full article
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18 pages, 5712 KiB  
Article
A Fractional Fourier Transform-Based Channel Estimation and Equalization Algorithm for Mud Pulse Telemetry
by Jingchen Zhang, Zitong Sha, Lei Wan, Yishan Su, Jiang Zhu and Fengzhong Qu
J. Mar. Sci. Eng. 2025, 13(8), 1468; https://doi.org/10.3390/jmse13081468 - 31 Jul 2025
Abstract
Mud pulse telemetry (MPT) systems are a promising approach to transmitting downhole data to the ground. During transmission, the amplitudes of pressure waves decay exponentially with distance, and the channel is often frequency-selective due to reflection and multipath effect. To address these issues, [...] Read more.
Mud pulse telemetry (MPT) systems are a promising approach to transmitting downhole data to the ground. During transmission, the amplitudes of pressure waves decay exponentially with distance, and the channel is often frequency-selective due to reflection and multipath effect. To address these issues, this work proposes a fractional Fourier transform (FrFT)-based channel estimation and equalization method. Leveraging the energy aggregation of linear frequency-modulated signals in the fractional Fourier domain, the time delay and attenuation parameters of the multipath channel can be estimated accurately. Furthermore, a fractional Fourier domain equalizer is proposed to pre-filter the frequency-selective fading channel using fractionally spaced decision feedback equalization. The effectiveness of the proposed method is evaluated through a simulation analysis and field experiments. The simulation results demonstrate that this method can significantly reduce multipath effects, effectively control the impact of noise, and facilitate subsequent demodulation. The field experiment results indicate that the demodulation of real data achieves advanced data rate communication (over 12 bit/s) and a low bit error rate (below 0.5%), which meets engineering requirements in a 3000 m drilling system. Full article
(This article belongs to the Section Ocean Engineering)
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16 pages, 2647 KiB  
Article
“Habari, Colleague!”: A Qualitative Exploration of the Perceptions of Primary School Mathematics Teachers in Tanzania Regarding the Use of Social Robots
by Edger P. Rutatola, Koen Stroeken and Tony Belpaeme
Appl. Sci. 2025, 15(15), 8483; https://doi.org/10.3390/app15158483 (registering DOI) - 30 Jul 2025
Abstract
The education sector in Tanzania faces significant challenges, especially in public primary schools. Unmanageably large classes and critical teacher–pupil ratios hinder the provision of tailored tutoring, impeding pupils’ educational growth. However, artificial intelligence (AI) could provide a way forward. Advances in generative AI [...] Read more.
The education sector in Tanzania faces significant challenges, especially in public primary schools. Unmanageably large classes and critical teacher–pupil ratios hinder the provision of tailored tutoring, impeding pupils’ educational growth. However, artificial intelligence (AI) could provide a way forward. Advances in generative AI can be leveraged to create interactive and effective intelligent tutoring systems, which have recently been built into embodied systems such as social robots. Motivated by the pivotal influence of teachers’ attitudes on the adoption of educational technologies, this study undertakes a qualitative investigation of Tanzanian primary school mathematics teachers’ perceptions of contextualised intelligent social robots. Thirteen teachers from six schools in both rural and urban settings observed pupils learning with a social robot. They reported their views during qualitative interviews. The results, analysed thematically, reveal a generally positive attitude towards using social robots in schools. While commended for their effective teaching and suitability for one-to-one tutoring, concerns were raised about incorrect and inconsistent feedback, language code-switching, response latency, and the lack of support infrastructure. We suggest actionable steps towards adopting tutoring systems and social robots in schools in Tanzania and similar low-resource countries, paving the way for their adoption to redress teachers’ workloads and improve educational outcomes. Full article
(This article belongs to the Special Issue Advances in Human–Machine Interaction)
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17 pages, 1988 KiB  
Article
Computational Design of Potentially Multifunctional Antimicrobial Peptide Candidates via a Hybrid Generative Model
by Fangli Ying, Wilten Go, Zilong Li, Chaoqian Ouyang, Aniwat Phaphuangwittayakul and Riyad Dhuny
Int. J. Mol. Sci. 2025, 26(15), 7387; https://doi.org/10.3390/ijms26157387 (registering DOI) - 30 Jul 2025
Abstract
Antimicrobial peptides (AMPs) provide a robust alternative to conventional antibiotics, combating escalating microbial resistance through their diverse functions and broad pathogen-targeting abilities. While current deep learning technologies enhance AMP generation, they face challenges in developing multifunctional AMPs due to intricate amino acid interdependencies [...] Read more.
Antimicrobial peptides (AMPs) provide a robust alternative to conventional antibiotics, combating escalating microbial resistance through their diverse functions and broad pathogen-targeting abilities. While current deep learning technologies enhance AMP generation, they face challenges in developing multifunctional AMPs due to intricate amino acid interdependencies and limited consideration of diverse functional activities. To overcome this challenge, we introduce a novel de novo multifunctional AMP design framework that enhances a Feedback Generative Adversarial Network (FBGAN) by integrating a global quantitative AMP activity regression module and a multifunctional-attribute integrated prediction module. This integrated approach not only facilitates the automated generation of potential AMP candidates, but also optimizes the network’s ability to assess their multifunctionality. Initially, by integrating an effective pre-trained regression and classification model with feedback-loop mechanisms, our model can not only identify potential valid AMP candidates, but also optimizes computational predictions of Minimum Inhibitory Concentration (MIC) values. Subsequently, we employ a combinatorial predictor to simultaneously identify and predict five multifunctional AMP bioactivities, enabling the generation of multifunctional AMPs. The experimental results demonstrate the efficiency of generating AMPs with multiple enhanced antimicrobial properties, indicating that our work can provide a valuable reference for combating multi-drug-resistant infections. Full article
(This article belongs to the Special Issue Application of Artificial Intelligence in Molecular Sciences)
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17 pages, 14808 KiB  
Article
Operatic Singing Biomechanics: Skeletal Tracking Sensor Integration for Pedagogical Innovation
by Evangelos Angelakis, Konstantinos Bakogiannis, Anastasia Georgaki and Areti Andreopoulou
Sensors 2025, 25(15), 4713; https://doi.org/10.3390/s25154713 (registering DOI) - 30 Jul 2025
Abstract
Operatic singing, traditionally taught through empirical and subjective methods, demands innovative approaches to enhance its pedagogical effectiveness today. This paper introduces a novel integration of advanced skeletal tracking technology into a prototype framework for operatic singing pedagogy research. Using the Microsoft Kinect Azure [...] Read more.
Operatic singing, traditionally taught through empirical and subjective methods, demands innovative approaches to enhance its pedagogical effectiveness today. This paper introduces a novel integration of advanced skeletal tracking technology into a prototype framework for operatic singing pedagogy research. Using the Microsoft Kinect Azure DK sensor, this prototype extracts detailed data on spinal, cervical, and shoulder alignment and movement data, with the aim of quantifying biomechanical movements during vocal performance. Preliminary results confirmed high face validity and biomechanical relevance. The incorporation of skeletal-tracking technology into vocal pedagogy research could help clarify certain technical aspects of singing and enhance sensorimotor feedback for the training of operatic singers. Full article
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27 pages, 12164 KiB  
Article
Neural Network Adaptive Attitude Control of Full-States Quad Tiltrotor UAV
by Jiong He, Binwu Ren, Yousong Xu, Qijun Zhao, Siliang Du and Bo Wang
Aerospace 2025, 12(8), 684; https://doi.org/10.3390/aerospace12080684 - 30 Jul 2025
Abstract
The control stability and accuracy of quad tiltrotor UAVs is improved when encountering external disturbances during automatic flight by an active disturbance rejection control (ADRC) parameter self-tuning control strategy based on a radial basis function (RBF) neural network. Firstly, a nonlinear flight dynamics [...] Read more.
The control stability and accuracy of quad tiltrotor UAVs is improved when encountering external disturbances during automatic flight by an active disturbance rejection control (ADRC) parameter self-tuning control strategy based on a radial basis function (RBF) neural network. Firstly, a nonlinear flight dynamics model of the quad tiltrotor UAV is established based on the approach of component-based mechanistic modeling. Secondly, the effects of internal uncertainties and external disturbances on the model are eliminated, whilst the online adaptive parameter tuning problem for the nonlinear active disturbance rejection controller is addressed. The superior nonlinear function approximation capability of the RBF neural network is then utilized by taking both the control inputs computed by the controller and the system outputs of the quad tiltrotor model as neural network inputs to implement adaptive parameter adjustments for the Extended State Observer (ESO) component responsible for disturbance estimation and the Nonlinear State Error Feedback (NLSEF) control law of the active disturbance rejection controller. Finally, an adaptive attitude control system for the quad tiltrotor UAV is constructed, centered on the ADRC-RBF controller. Subsequently, the efficacy of the attitude control system is validated through simulation, encompassing a range of flight conditions. The simulation results demonstrate that the Integral of Absolute Error (IAE) of the pitch angle response controlled by the ADRC-RBF controller is reduced to 37.4° in comparison to the ADRC controller in the absence of external disturbance in the full-states mode state of the quad tiltrotor UAV, and the oscillation amplitude of the pitch angle response controlled by the ADRC-RBF controller is generally reduced by approximately 50% in comparison to the ADRC controller in the presence of external disturbance. In comparison with the conventional ADRC controller, the proposed ADRC-RBF controller demonstrates superior performance with regard to anti-disturbance capability, adaptability, and tracking accuracy. Full article
(This article belongs to the Section Aeronautics)
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