Search Results (5,676)

Background/Objectives: To evaluate construct (convergent and divergent) validity and conduct confirmatory factor analysis (CFA) of the National Center on Health, Physical Activity and Disability (NCHPAD) Wellness Assessment (NWA) tool. Methods: A cross-sectional survey validation study utilizing secondary data. We assessed Spearman correlations between NWA and 36-Item Short Form Health Survey (SF-36), NWA and Godin Leisure-Time Exercise Questionnaire (GLTEQ) and NWA and Modified Fatigue Impact Scale (MFIS) scores to determine construct validity. A CFA was conducted to test the appropriateness of a three-factor model for NWA. Results: Data from 149 participants were used to assess construct validity and from 180 participants for CFA. Both correlations between NWA mental wellness domain and SF-36 mental component scores and between NWA emotional/spiritual wellness domain and SF-36 emotional well-being scores were 0.61 (p < 0.001 for both). The correlation between NWA physical wellness domain and SF-36 physical component score was −0.06 (p = 0.45). The correlations of NWA with GLTEQ overall and with health contribution scores were 0.26 and 0.30, respectively (p < 0.001 for both). The correlations of all NWA domain and MFIS subscale scores ranged between −0.42 and −0.25 (p < 0.05). The CFA model’s comparative fit index was 0.90. Conclusions: The NWA physical wellness domain did not demonstrate strong convergent validity, as mental and emotional/spiritual wellness domains did. All domains showed strong divergent validity, and CFA showed evidence supporting a three-factor model. Future efforts will emphasize refining and reevaluating the physical wellness domain until it achieves strong psychometric properties. Full article

Wind turbine blades are subjected to complex environmental conditions during long-term operation, which may lead to structural degradation and performance loss. To ensure structural integrity, fatigue testing prior to deployment is essential. This paper proposes a vision-based method for measuring the full-cycle breathing deformation of wind turbine blades during fatigue testing. The method captures dynamic image sequences of the blade’s hotspot cross-section using industrial cameras and employs a feature-based template matching approach to reconstruct the three-dimensional coordinates of target points. Through coordinate transformation, the deformation trajectories are obtained, enabling quantitative analysis of the blade’s dynamic responses in both flapwise and edgewise directions. A dedicated hardware–software system was developed and validated through full-scale fatigue experiments. Quantitative comparison with strain gage measurements shows that the proposed method achieves mean absolute deviations of 0.84 mm and 0.93 mm in two independent experiments, respectively, with closely matched deformation trends under typical loading conditions. These results demonstrate that the proposed method can reliably capture the global deformation behavior of the blade with millimeter-level accuracy, while significantly reducing instrumentation complexity compared to conventional contact-based approaches. The proposed method provides an effective and practical solution for full-field dynamic deformation measurement in blade fatigue testing, offering strong potential for structural health monitoring and early damage detection in wind turbine systems. Full article

In this work, the focus is laid on the mean stress effect on the fatigue strength of thin-walled rectangular hollow section T-joints made of high-strength steel S960 M x-treme. The specimens are cyclically tested at a stress ratio of R = −1 and R = 0.1 in both as-welded and ground (weld-profiled) conditions. In the context of nominal stress evaluations, the ground specimens demonstrate a distinct advantage in contrast to the as-welded condition, exhibiting an increase of +33% at R = 0.1 and +16% at R = −1. Based on the experimental results, a corresponding Haigh diagram is evaluated, revealing a notable difference in the mean stress sensitivity, with M₁ = 0.58 for the as-welded condition and M₁ = 0.39 for the ground condition. Finally, mean stress factors are presented, enabling feasible application in the fatigue design of welded and post-treated structures. The resulting factors are compared with values from the literature for steel applications, showing an increased mean stress influence using high-strength steel as the base material. Full article

One of the main causes of failure in Insulated Gate Bipolar Transistor (IGBT) modules used in high-power conversion applications is thermal-stress-induced degradation. In this paper, an experimental testing setup for thermal stress and real-time degradation monitoring, as well as a deep neural network (DNN)-based lifetime prediction of IGBT modules under thermo-electrically stressed inverter operation, is proposed. A two-level SVPWM inverter is implemented to create a hybrid power cycling test platform that imposes well-defined junction-temperature swings representative of real-world operation by combining controlled electrical loading and active induction heating with water cooling. Throughout the aging process, on-state voltage and module temperature are constantly monitored to identify degradation precursors associated with thermo-mechanical fatigue. A physics-based Coffin–Manson lifetime model is fitted using failure datasets to characterize temperature-dependent lifetime behavior. An offline deep neural network (DNN) is trained on degradation trajectories derived from on-state collector–emitter voltage (V_ce,on) to predict remaining useful lifetime. This approach uses partial degradation histories for accurate early-life prediction. The proposed DNN model for competitive and computationally efficient lifetime prediction is validated experimentally on several IGBT modules under different thermal stresses, and its accuracy is compared with other prediction methods. Full article

Fatigue failure in scaffolding components poses significant risks to worker safety, particularly in high-altitude construction environments. This study investigates the fatigue behavior of scaffolding stirrups, a critical structural element prone to premature failure. The objective is to analyze the fatigue damage mechanisms in stirrups through a combined experimental and numerical approach. Mechanical characterization and micro-hardness testing were conducted to assess the material properties of the stirrup, while finite element modeling (FEM) was employed to simulate its performance under cyclic loading. The Johnson–Cook material model was utilized to compare experimental hysteresis curves with FEM results, validating the numerical approach. Additionally, the Extended Finite Element Method (XFEM) was applied to model crack initiation and propagation. Results reveal that material hardening and fatigue crack growth are the primary causes of stirrup failure, with distinct fatigue zones and crack paths identified. The study quantifies the relationship between crack growth stages and stirrup bending, providing insights into the failure process. These findings contribute to improving the safety and lifespan of scaffolding systems by identifying key factors influencing stirrup durability. Full article

The mechanical response of 7xxx aluminum alloys is strongly influenced by both alloy chemistry and the resulting microstructure. In this study, the effect of precipitate characteristics on the fatigue behavior of three 7xxx aluminum alloys with different total amounts of main alloy elements was systematically investigated. Quantitative microstructural characterization was performed under T6 and T74 heat-treatment conditions by combining scanning electron microscopy, transmission electron microscopy, and electron backscatter diffraction. Meanwhile, hardness measurements, room-temperature tensile tests, and fatigue crack growth experiments were carried out to evaluate the mechanical behavior. The results show that, within the present alloy set, the over-aged condition and the alloys with higher overall alloying levels exhibited lower fatigue crack growth rates, which correlated with the coarsening of intragranular precipitates. Such microstructural evolution is suggested to facilitate dislocation motion and thereby reduce fatigue damage associated with dislocation pile-up in the present alloy set. In this work, three typical 7xxx aluminum alloys with different alloying levels were systematically investigated under T6 and T74 conditions. A statistical criterion was established to distinguish GPII zones from η′ precipitates, and a model linking precipitate characteristics to fatigue crack growth behavior was further developed. The present study aims to provide a quantitative framework for understanding and predicting the fatigue behavior of 7xxx aluminum alloys with different total amounts of main alloy elements. Full article

Traditional simulators predominantly operate with position control at specific frequencies and largely neglect the appropriate imposition of accelerations on the structure. This restricts the application of realistic accelerations during fatigue testing and reduces the fidelity of tests to real road conditions. This study proposes an integrated experimental–analytical framework for motorcycle testing under laboratory conditions. Within the framework, smooth displacement reference signals are generated from noisy field-measured acceleration signals through Fourier-based harmonic curve fitting and analytic integration. Subsequently, a nonlinear adaptive backstepping control algorithm is designed to ensure accurate replication of these references within the 0–25 Hz bandwidth under parametric uncertainties. This approach provides a valuable and repeatable alternative to conventional on-road testing, ensuring that realistic road-induced accelerations are accurately imposed on the motorcycle structure during fatigue testing. Experimental signals were collected from a motorcycle on three different road surfaces, and the performance of the generated reference signals was evaluated in both the time and frequency domains. Experiments conducted on a real-time industrial controller demonstrated that the proposed controller exhibits superior tracking performance across all road profiles, achieving a Root Mean Square Error (RMSE) as low as 1.3 mm, while the Fourier-based reconstruction achieves $R^2$ values approaching 0.97. The controller maintains consistent precision and negligible performance variance despite significant differences in road characteristics, thereby offering a controlled and cost-effective laboratory simulation alternative to conventional on-road durability testing. Full article

Background/Objective: Delaying muscle fatigue could alleviate economic and food security, and welfare concerns associated with transporting market-weight pigs to harvest. Previous research demonstrates barrow nicotinamide riboside (NR) supplementation at varying doses during the last 10 d of finishing shows to be a countermeasure to muscle fatigue by reducing muscle fiber recruitment and increasing mitochondrial DNA expression in a dose-dependent manner. Therefore, this study aims to determine if a greater NR dose further enhances barrow fatigue resistance and characterize muscle mitochondria content and efficiency. Methods: Barrows (N = 87) were assigned to one of two dietary NR supplementation doses (TRT): 0 (0NR) or 150 (150NR) mg/kg body weigh NR administered during the last 14 d of finishing. Muscle (MUS) biopsies were collected on supplementation d (DAY) 0, 7 and 14 from three hind-leg muscles for NAD+ quantification and mitochondrial DNA expression and efficiency. On days 15 and 16, barrows were subjected to a performance test until they were subjectively exhausted. Electromyography data collection during the performance test were divided into five periods (PER) and included normalized root mean square (nRMS) from the same muscles. Results: There were no three-way interaction for nRMS (p > 0.83), but there were MUS × TRT and PER × TRT interactions (p < 0.05). During performance testing, 150NR had greater nRMS than 0NR in the bicep femoris (BF) and tensor fasciae latae (TFL; p < 0.01), but there were no differences in the semitendinosus (ST; p = 0.77). Treatments did not differ during PER 1 and 2 (p > 0.14) but 150NR had greater nRMS than 0NR during PER 3, 4 and 5 (p < 0.01) across all muscles. There was no three-way interaction for normalized (nNAD+; p = 0.14), but there was a DAY × TRT interaction (p < 0.05). There were no differences between 0NR and 150NR at d 0 (p = 0.95); however, by d 7 and 14, 150NR muscles had greater nNAD+ than 0NR muscles (p < 0.01). There tended to be a three-way interaction for mitochondrial DNA expression (p = 0.09). At supplementation d 14, all 150NR muscles had greater mitochondrial DNA expression and electron transport chain complex I and II activities (p < 0.01). When normalized to citrate synthase activity, electron transport chain complex I and II activity did not differ (p > 0.05). Conclusions: Large-dose NR supplementation appears to support sustained muscle fiber recruitment during prolonged activity and enhance fatigue resilience, primarily through increased NAD+ and mitochondrial biomarkers abundance and not through mitochondrial efficiency. Full article

Introduction: Advancements in thermo-mechanical surface treatment of endodontic nickel–titanium (NiTi) instruments introduced another aspect of variation. Particularly related to their metallurgy, which influences their behaviour in relation to temperature. This is clinically significant, considering the variation in the temperatures inside the root canal during instrumentation. This study aimed to compare the effects of different temperatures on the bending stiffness, cyclic fatigue resistance, and cutting efficiency of two reciprocating heat-treated NiTi files: R-Motion (RM) and WaveOne Gold (WOG). Methodology: Bending stiffness was examined in a temperature-controlled water bath, measuring the maximum force in Newtons during a 3 mm tip horizontal displacement. The cyclic fatigue resistance was tested in a simulated stainless-steel canal (35° curvature, 6 mm radius) in dynamic mode at 22 °C, 37 °C, and 45 °C. Time to fracture (TTF) and length of fractured fragment were recorded, and representative samples were examined using scanning electron microscopy. The cutting efficiency was assessed using bovine bone slabs measuring 1.5 mm in thickness and 15 mm in width. The files were activated in reciprocation mode for three minutes while resting on the upper surface of the slab, while submerged in a water bath maintained at 22 °C, 37 °C, or 45 °C. The maximum cutting depth was measured in millimetres under magnification. Additionally, Differential Scanning Calorimetry (DSC) analysis was performed for three specimens of each file type. Results: RM exhibited significantly higher TTF, longer fractured fragments, and smaller cutting depths than WOG across all temperatures. The RM was significantly stiffer at 37 °C and 45 °C only. For each file type, increasing the temperature was associated with a significant increase in stiffness (p < 0.01), except for WOG between 22 °C and 37 °C (p = 0.199). The TTF was significantly higher in RM at 22 °C, while the TTF in WOG increased significantly with lower temperatures. No effect was observed on the length of the fractured fragment. Lower temperatures were also associated with reduced cutting efficiency in both files. Conclusions: Temperature has a significant impact on the properties and performance of RM and WOG and should be considered during instrumentation. File design has a greater influence on their strength and cutting ability than their transformation behaviour related to heat treatment. Full article

Background: Fatigue is a common and distressing symptom in inflammatory bowel disease (IBD), yet it is rarely addressed in routine care. Most available evidence comes from Western and East Asian populations, with limited data from the Middle East. Objectives: To estimate the prevalence of fatigue in Saudi patients with IBD, using the Arabic-validated Brief Fatigue Inventory (BFI-A), and to examine associations with demographic, clinical, treatment, and laboratory factors. Methods: This cross-sectional study was conducted at King Abdulaziz University Hospital, Saudi Arabia, between March and December 2025. Patients aged ≥12 years with histologically confirmed IBD completed a structured telephone interview. Demographic characteristics, comorbidities, IBD control scores, Montreal classification, medication history, and laboratory results were collected. Patients experiencing severe flares, hospitalization, or another primary condition likely to explain fatigue were excluded. Fatigue severity was classified as none, mild, moderate, or severe. Associations were tested using chi-square and Kruskal–Wallis tests. Results: Among 286 patients (mean age, 30.8 ± 9.1 years; 57.7% male), 23.1% reported mild fatigue, 36.4% moderate fatigue, and 19.2% severe fatigue on the BFI-A. Fatigue severity was not associated with demographic factors, IBD type or phenotype, treatment exposure, or most laboratory parameters. Only serum iron (p = 0.011) and erythrocyte sedimentation rate (p = 0.023) differed across fatigue categories, without a clear dose–response pattern. Conclusions: Fatigue affects more than half of Saudi patients with IBD and is not explained by routine clinical or laboratory factors. Routine fatigue assessment and attention to biopsychosocial contributors may improve IBD care. Full article

Five groups of recycled aggregate concrete (RAC) mixtures with mass replacement ratios of emery (0, 5%, 10%, 15%, 20%) were prepared. The cubic compressive strength, splitting tensile strength, flexural strength, and flexural fatigue properties under stress levels of 0.6, 0.7, and 0.9 were tested. The fatigue reliability of RAC was analyzed based on the Miner model. Test results indicate that emery incorporation significantly improves the mechanical properties, flexural fatigue properties, and fatigue reliability of RAC. Compared with the reference group (0% emery), the 28-day cubic compressive strength, splitting tensile strength, and flexural strength of RAC with 20% emery increase by 18.62%, 27.35%, and 20.28%, respectively. The flexural fatigue life increases by up to 135.8% under high stress level (0.9). Flexural fatigue performance and fatigue reliability decrease with increasing stress level. The S-N curve was obtained based on the Wöhler mathematical model with high fitting reliability (R² > 0.95). Full article

Mevalonate kinase deficiency (MKD) is a rare autosomal recessive autoinflammatory disorder with marked clinical heterogeneity, frequently leading to delayed diagnosis. We describe a 71-year-old woman with lifelong episodic inflammatory symptoms beginning in infancy, including recurrent fevers, lymphadenopathy, and gastrointestinal and mucocutaneous manifestations, later evolving into intermittent arthralgia, myalgia, and fatigue. A unifying diagnosis was established when genetic testing identified two missense pathogenic MVK variants consistent with compound heterozygous MKD, supported by elevated serum IgD levels and a characteristic clinical phenotype. This case illustrates the essential role of molecular genetic testing in resolving prolonged diagnostic odyssey, in guiding surveillance for complications such as AA amyloidosis, and enabling targeted therapeutic strategies. Full article

This study investigates the thermo-mechanical response of geocell-reinforced concrete pavements through scaled model tests and three-dimensional finite element analyses. Static, thermal, traffic, and coupled temperature–loading tests were conducted to clarify the deformation evolution, strain distribution, and damage-related response of the reinforced structure. The results show that, under static loading, pavement settlement evolves through three stages, namely initial compaction, plastic development, and stable strengthening, indicating progressive mobilization of geocell confinement. Under thermal loading, slab strain exhibits pronounced spatial and temporal non-uniformity, and the slab center is identified as the thermally sensitive zone. Under coupled temperature–loading conditions, both strain and settlement show a non-monotonic response near 1.1–1.3 kN, suggesting a potential damage-initiation range. Post-test crack observations further provide direct qualitative evidence that local cracking damage occurred in the slab under representative loading conditions. Under traffic loading, permanent deformation accumulates with load repetitions and is highly sensitive to load amplitude, indicating a load-sensitive transition in cumulative deformation behavior rather than a definitive fatigue threshold. Numerical results further show that geocell reinforcement reduces central settlement by 17.4% relative to plain concrete pavement and by 7.6% relative to doweled pavement, while producing a smoother deflection basin and a more uniform stress distribution. Parametric analyses indicate that the optimum geocell height is approximately one-third of the slab thickness; beyond this range, the marginal reinforcement benefit decreases. Overall, the results demonstrate that geocell reinforcement can effectively improve load transfer, deformation compatibility, and thermo-mechanical stability of concrete pavements under the investigated conditions. Full article

Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disorder, characterized by symptoms such as post-exertional malaise (PEM) and cognitive impairments. This study assessed reaction time (RT) metrics in three-dimensional (3D) visual tasks with the aim of objectively quantifying the cognitive impairments in ME/CFS patients compared to controls. Methods: A total of 120 participants (60 ME/CFS patients and 60 controls) were recruited at the Department of Ophthalmology, Universität of Erlangen-Nürnberg. RT was assessed using a virtual reality–oculomotor test system, presenting 3D stimuli at three disparity levels (275″, 550″, and 1100″) within three gaming repetitions (R1, R2, and R3). Mixed-effects models were used to evaluate group differences, with age and gender as covariates. Pairwise contrasts were calculated to assess changes across repetitions. Fatigue self-assessments were recorded by validated questionnaires, (FACIT Fatigue Scale, Chalder Fatigue Scale, Bell Score and Health Assessment Questionnaire), and their correlation with RT metrics was portrayed using a Spearman correlation matrix. Results: Estimated means (EM-means) for RT were significantly prolonged in ME/CFS patients compared to controls at disparity 275″ (1969 ms vs. 1384 ms; p = 0.0001), 550″ (1409 vs. 1071 ms; p = 0.0012) and 1100″ (1126 ms vs. 891 ms; p = 0.00223). Age was a significant covariate (p < 0.001), while gender showed no effect. Both groups demonstrated improvements in RT over repetitions; however, ME/CFS patients showed a significantly lower improvement compared to controls, reaching significance in R3 (p = 0.0042). RT metrics did not correlate with patients’ self-assessment scores. Conclusions: ME/CFS patients showed consistently slower RTs compared to controls, particularly in later, easier gaming repetitions, potentially reflecting the impact of fatigue. Full article

Crumb rubber-modified asphalt concrete (CMAC) has gained increasing attention as a sustainable pavement material capable of improving mechanical performance while utilizing waste tire resources. This study investigates the rutting resistance and fatigue behavior of CMAC using a combined experimental and mechanistic–empirical modeling approach. Asphalt mixtures containing 0–25% crumb rubber by binder weight were prepared and evaluated through Marshall stability and indirect tensile fatigue tests, whereas Fourier-transform infrared spectroscopy (FTIR) was used to examine binder–rubber interactions. The results indicate that crumb rubber significantly influences both the volumetric and mechanical properties of asphalt mixtures. Mixtures containing 10–15% crumb rubber exhibited optimal performances, achieving up to 36% higher Marshall stability and improved fatigue life compared with conventional asphalt mixtures. FTIR analysis revealed that rubber particle swelling and limited chemical interactions enhanced binder elasticity and improved binder–aggregate compatibility. However, excessive rubber content (≥20%) resulted in reduced stability owing to increased binder absorption and decreased effective binder film thickness. A mechanistic–empirical model incorporating viscoelastic, viscoplastic, and fatigue damage parameters successfully reproduced the experimental trends and identified the same optimal rubber content range. The findings demonstrate that CMAC with a moderate rubber content can enhance pavement durability and structural performance while promoting environmentally sustainable road construction through the reuse of waste tires. Full article