Search Results (129)

Tick-borne encephalitis virus (TBEV) causes tick-borne encephalitis (TBE), a severe disease of the human central nervous system. Currently, the data on the genetic variants of TBEV in Kyrgyzstan are practically absent. Therefore, the aim of this study was to analyze and describe the genetic diversity of TBEV in this region. The complete genome sequences of seven TBEV strains from the collection of the Scientific Centre for Family Health and Human Reproduction Problems (Irkutsk, Russia) were determined. These strains, isolated from Ixodes persulcatus ticks from Kyrgyzstan, were sequenced using the next generation sequencing approach on a MiSeq high-performance sequencer (Illumina, San Diego, CA, USA). A molecular genetic analysis of the obtained sequences, along with sequences of two previously isolated TBEV strains from Kyrgyzstan available in the GenBank database, demonstrated that the Siberian subtype of three genetic lineages (Zausaev, Vasilchenko and Bosnia) is predominantly distributed in Kyrgyzstan. The Far Eastern subtype of TBEV is also present. To date, this location probably represents the southernmost boundary of these TBEV subtypes’ ranges. Full article

This study examines a seven-week informal familycentric rocketry pilot program designed for Latina girls in grades 5 and 6 and their parents. Grounded in Community Cultural Wealth and Culturally Sustaining Pedagogy, the program integrated Family Problem-Based Learning to position families as co-educators in science learning. Through activities such as designing NASA-style mission patches, constructing egg-drop devices, and launching rockets, the program sought to center family knowledge, bilingual practices, and cultural values within physical science experiences. Data reported here were collected through mid- and post-program surveys with both parents and daughters. Responses indicate strong engagement from families, with parents reporting increased high confidence in supporting their daughters’ science learning and daughters expressing enjoyment and strong interest in science learning. Both groups valued the use of English and Spanish and the program’s emphasis on collaborative, family-centered participation. Responses highlight the potential of culturally sustaining, familycentric approaches to address the underrepresentation of Latina women in Science, Technology, Engineering, and Math (STEM) by fostering a sense of belonging. This study contributes to informal science education by demonstrating how families can be centered in a program focused on physical science. School-based outreach of this kind may also strengthen families and parent–child relationships. Full article

Initial teacher education plays a decisive role in preparing future educators to establish meaningful and reciprocal relationships with families that support children’s learning across contexts. Moving beyond traditional, school-centred notions of family involvement, this study adopts a family engagement (FE) perspective to examine preservice early childhood teachers’ perceptions of their preparation, the difficulties they anticipate, and their self-efficacy in working with families. A total of 181 Portuguese preservice early childhood teachers completed a questionnaire comprising three scales: Training Evaluation, Anticipated Difficulties, and Self-efficacy. The Training Evaluation Scale revealed two dimensions (theoretical and practical), which were used in a Latent Profile Analysis that identified three groups (Positive, Neutral, and Low-rating). Participants within each profile showed consistent evaluations across both dimensions. Significant differences emerged between profiles in perceived difficulties, with self-efficacy lowest in the low-rating group. Overall, the findings highlight that variations in perceived training quality are closely associated with preservice teachers’ confidence and their expectations regarding the challenges of engaging families. These results underscore the importance of more systematic, integrated and practice-oriented approaches within initial teacher education to support a shift towards family engagement practices that recognise families as active partners in children’s learning from the outset of teachers’ professional careers. Full article

Background and Objectives: Paediatric palliative care in Romania is underdeveloped and unevenly distributed, which creates major difficulties in accessing services for children with life-limiting illnesses and their families. The lack of a dedicated national strategy, the shortage of specialised staff, and socio-economic barriers exacerbate the vulnerability of these groups. This study aimed to explore parents’ and caregivers’ experiences, to analyse the perspectives of public institutions and NGOs involved in supporting these children, and to identify the main barriers and facilitators in accessing paediatric palliative care. Materials and Methods: Given that all data were collected exclusively through focus group discussions, this study employed a qualitative design based on three focus groups guided by a semi-structured interview guide. The analysis was conducted using MAXQDA software, which enabled the coding and synthesis of emerging themes. Participants were parents/caregivers of children with life-limiting illnesses, representatives of public institutions, and members of relevant NGOs in Bacău County, Romania. Purposive sampling was used to capture diverse and experience-based perspectives, resulting in a total of 24 participants across three focus groups—parents and caregivers (n = 11), public institution representatives (n = 7), and NGO representatives (n = 6). No individual semi-structured interviews were conducted. Results: The analysis highlighted a complex typology of medical, emotional, social, educational, and spiritual needs of children and their families. Parents reported experiences of abandonment in the curative system, emphasising the importance of pain control, safety, and community support. Public institutions acknowledged the lack of skills and inter-sectoral coordination, while NGOs pointed to structural barriers and the low visibility of these children. Major needs include access to specialised care, psychological support, respite services for carers, financial and administrative assistance, education, and spiritual counselling. A significant obstacle is the lack of up-to-date statistical data needed to inform public policy. Conclusions: Paediatric palliative care should be considered a national priority through the development of a dedicated strategy, the expansion of specialised services, and the strengthening of partnerships between the public and non-governmental sectors. An integrated, child- and family-centred approach addressing the medical, social, emotional, and spiritual dimensions of care is essential. The results highlight the need for continuous staff training, information campaigns, and community support mechanisms to reduce inequalities and improve the quality of life of children with life-limiting illnesses. Full article

Furo[3,2-b]pyrroles (FPs) are important members of the heteropentalene family. In particular, furo[3,2-b]pyrrole-5-carboxylates (FPcs) are commonly used as versatile building blocks for the synthesis of a large library of FP derivatives. Their structure with five potential reaction centres and an electron-rich character enables a wide range of transformations, from simple substitutions to multi-step reactions, yielding complex compounds with a furo[3,2-b]pyrrole scaffold. Many furo[3,2-b]pyrrole derivatives exhibit promising biological activity, while others have been employed in the construction of π-conjugated fused systems for optoelectronics. Efficient synthetic routes to furo[3,2-b]pyrrole derivatives are therefore of considerable interest. This review focuses on the synthetic methods leading to furo[3,2-b]pyrrole-5-carboxylates (FPcs), from the first successful attempts in the 1970s to recent approaches. Various methodologies are reported for the construction of complex molecules built from furo[3,2-b]pyrrole-5-carboxylates, emphasising their utility in the synthesis of fused heterocycles. This review also covers recent advances in screening for biological activity and applications such as fluorescent dyes. Full article

Background: This study examines how the Yörük community in Türkiye balances the preservation of traditional childrearing practices with modernization and compulsory schooling. Context: The Yörüks, a historically nomadic Turkic people, possess a distinct cultural identity that centres around oral knowledge transmission, family-based education, and pastoral living. Methods: A qualitative phenomenological approach was used. Data Collection: In-depth semi-structured interviews were conducted with 11 Yörük participants selected through purposive sampling. Results: Four core themes were identified: Yörük culture, expectations of children, childrearing practices, and perceptions of schooling. Tensions emerge between traditional responsibilities, gender roles, and modern schooling structures. Conclusions: The study shows that cultural dissonance with the national education system contributes to educational exclusion and identity tension among Yörük children. Theoretical Implications: This study challenges dominant educational paradigms that overlook minority epistemologies and underscores the need to incorporate pastoralist worldviews into inclusive education theory. Practical Implications: It calls for flexible, culturally responsive policies, such as mobile or seasonal schooling and culturally inclusive curricula. Research Implications: Future studies could focus on the longitudinal impacts of modernization on the educational outcomes of pastoral communities or conduct comparative studies with other nomadic groups. Full article

Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that causes severe motor, respiratory and communication impairment and imposes a high psychosocial burden on patients and families. Recent evidence shows that integrated neuropalliative care—early collaboration between neurology and palliative services with community support—improves quality of life and reduces avoidable hospitalisations. Yet there are few descriptions of how such integration is operationalised. Objective: This study examines a Community-Integrated Neuropalliative Pathway (CINP) implemented in the province of Modena (Emilia-Romagna, Italy), analysing how neurology, palliative care and emergency services collaborate to provide continuous, person-centred care for people with ALS. Methods: A single, holistic case study was conducted following Yin’s analytical approach. Data sources included ten semi-structured interviews with neurologists, palliative physicians, nurses, home-care professionals and emergency clinicians; ethnographic observations in the ALS outpatient clinic; relevant organisational documents (the regional Clinical Pathway on ALS); and aggregated quantitative data from the palliative care registry (January 2023–December 2024). Thematic analysis with investigator triangulation was used to explore care integration, advance care planning and emergency coordination. Quantitative data were summarised descriptively. Results: Three interrelated themes were identified: (1) Progressive and flexible integration between neurology and palliative care. Neurologists remained longitudinal reference points while palliative teams were activated in response to evolving needs and became more relevant with the progression of the disease. Regular multidisciplinary meetings and shared discharge planning facilitated coordination. (2) The shared culture of advance care planning. Professionals framed advance care planning (ACP) as a relational, iterative process anchored in therapeutic relationships. Shared care plans, once completed, triggered an electronic Emergency Warning (“warning 118”) procedure that notified the emergency service of patient preferences. (3) The integration of palliative and emergency services. The warning system enabled emergency clinicians to respect care plans and avoid aggressive interventions during crises. Quantitative data on 47 ALS patients followed by territorial palliative services showed that 16 had an active Emergency Warning flag; among these, most died at home or in a hospice rather than in hospital. Conclusions: The Modena CINP exemplifies how a public health system can operationalise early neuropalliative integration and connect hospital, community and emergency services. The qualitative findings illustrate the cultural and organisational shifts required for continuous care, while the quantitative data show that the system is correctly used and that patients with the Emergency Warning activation died mostly at home or in a hospice. Lessons from this analytical case study can inform the development of similar pathways in other regions, although further research is needed to assess outcomes in larger populations and such models need to be adapted to local contexts. Full article

Background: Early childhood obesity is an urgent public health challenge, with long-term health risks. The 12-month fruehstArt intervention aims to improve healthcare for 3 to 6-year-olds with overweight and obesity in Germany through a family-centred approach, including home-based counselling with coaches, paediatric consultations, and a supportive web application for both German- and Turkish-speaking families. This process evaluation will examine the barriers and enabling factors critical for successful implementation, identify necessary adaptations to the intervention, and assess its quality and acceptability among families, coaches, and paediatricians. Methods: This formative evaluation will use a mixed-methods approach including qualitative and quantitative data. Semi-structured interviews will be conducted with parents, coaches, and paediatricians at two different time points. Interviews will be analysed using qualitative content analysis. An Implementation Quality Index assessing the four dimensions of dosage, adherence, quality of delivery, and participant responsiveness will be developed, based on data collected from coaches carrying out the home-based counselling and participating parents of the intervention group. Linear mixed models for repeated measures will be used to analyse the relationship between data of the Implementation Quality Index and the primary and secondary outcomes of the effectiveness evaluation. Conclusions: The formative evaluation of the fruehstArt intervention is expected to identify important determinants of the implementation and provide valuable insights for future strategies to improve implementation. By identifying barriers and facilitators to participation, this study aims to pave the way for an effective dissemination of the intervention and ultimately contribute to improved health outcomes for children. Full article

The Mediterranean Germplasm Gene Bank (MGG) of the CNR-IBBR in Bari (Italy) is the oldest gene bank of the Mediterranean area. Thanks to Vavilov, this area is considered an important gene centre. The first safeguarding activities of the MGG began in 1969 and continue today following traditional and innovative approaches. The strategy followed by the MGG for safeguarding plant genetic resources of Mediterranean origin and of agricultural interest is described in detail together with the activities and methods used. Some examples of rare agrobiodiversity discovered in the area are reported and described. The MGG seed collection (as ex situ conservation) contains about 59,000 accessions from 34 families, 208 genera and 872 species. Over 13,000 samples have been directly collected over time by exploration teams, while others have been acquired from 314 donor institutions through a seed exchange. MGG studies in the Mediterranean region show a severe genetic erosion of about 75%. The approach adopted by the CNR-IBBR research group to combat this phenomenon can be broken down into two main areas. Firstly, new collecting missions could secure still available valuable material as old landraces cultivated in the fields and gardens of less anthropized areas; the considerable experience and knowledge acquired over the span of five decades, accumulated through this endeavour, undoubtedly plays a pivotal role. Moreover, the integration of conservation methods, ex situ and on farm, for cultivated material, and predominantly in situ for wild species, is necessary for the sustainable development and use of Mediterranean plant genetics resources. In pursuit of this objective, the international standing of the MGG and its extensive network of collaborations represent a foundational element. Full article

Background: Although equine-assisted interventions (EAI) are gaining growing attention, their scientific evaluation among individuals with Alzheimer’s disease (AD) living in nursing homes remains limited. This study aimed to explore the lived experiences of an EAI program from the perspectives of the participants living with AD as well as their families and professional caregivers. Methods: Thirty non-directive interviews were conducted between June and July 2024 across several nursing homes in the Centre-Val de Loire region (France). The interviews were recorded, transcribed, and analyzed using thematic analysis. Results: Four main themes emerged from the analysis: (1) the experience with the horse, reflecting a unique relationship with the animal, the activities carried out, and perceived personality traits; (2) the environment of EAI sessions, offering a break from daily routines, encouraging contact with nature, and taking place in a setting specific to this type of intervention; (3) the implementation of the program within the institutional context, highlighting logistical aspects, environmental factors, and the adherence; (4) the effects of the intervention, including enhanced social interactions, memory stimulation, emotional engagement, and behavioral benefits. Conclusions: These findings provide insight into the multiple dimensions involved in an EAI program. By giving voice to both participants and their caregivers, this study emphasizes the value of qualitative approaches in deeply understanding the meaning and impact of these non-pharmacological interventions. Full article

Background: Parent education is a key component of family-centred care in neonatal intensive care units (NICUs). It supports positive parent-infant interactions, reduces parental stress and anxiety, and contributes to shorter hospital stays. Objectives: This paper reports on the adaptation of a South African parenting education intervention for parents of premature infants in the NICU: the NeuroSense PremmieEd programme. The study aimed to demonstrate the programme’s content validity, feasibility, and acceptability for preterm parent–infant dyads in public hospital NICUs, using a hybrid focus group discussion (FGD) method. The programme was based on an existing intervention and informed by literature on the components of parenting educational programmes and empirical data on parental expectations. Methods: A qualitative, iterative refinement process was undertaken using hybrid-format FGDs. A conceptual FGD was held during the design phase, followed by two consensus FGDs after pilot testing (reported separately). Stakeholders included end-users (mothers), clinicians, an instructional designer, a neurodevelopmental care expert, and programme facilitators. Results: The first FGD reviewed draft version 0.1 of the programme, confirming content relevance and clarity, while recommending adjustments, such as module integration, cultural and language alignment, and visual aids to support comprehension. Version 0.2 was then ready for pilot testing (reported elsewhere). The second and third FGDs led to refinements addressing emotional sensitivity in terminology, improved layout and readability, and the addition of home care guidance. Stakeholders highlighted the potential use of low-cost digital formats to enhance accessibility and standardisation. These revisions informed the final version 0.3. Conclusions: The hybrid FGD approach enabled input from diverse and geographically dispersed stakeholders. The NeuroSense PremmieEd programme was found to be feasible and acceptable by both mothers and healthcare professionals, supporting its suitability for broader implementation in resource-constrained settings. Full article

Background: Childhood Obesity is a significant and growing Public Health threat among Aboriginal and Torres Strait Islander (ATSI) children and adolescents in Australia. Health sectors in Australia have been focusing on health intervention programs across various states to prevent childhood obesity. This review aims to analyse the impact of obesity intervention programs conducted among children and adolescents of ATSI communities across Australia and report on the best practices for conducting future research. Objectives: This scoping review synthesised existing literature on the obesity prevention interventions programs among ATSI Children and Adolescents in Australia and examined their scope, implementation, and outcomes; evaluated their cultural appropriateness; and highlighted critical enablers and barriers. Methods: This scoping review analysed scholarly journal articles that reported on the findings of obesity intervention programs delivered across ATSI children and adolescents. Only Quasi-experimental and Randomized Control Trials (RCTs) were selected for the review. A full search has been carried out in Health databases such as Cochrane Library, Medline, PubMed, and ProQuest Central for the past 15 years. The framework of the Joanna Briggs Institute (JBI) for Scoping reviews was followed throughout this review. Results: Eleven studies met inclusion criteria. Findings were clustered into five themes: (i) community-led, systems-based interventions improved health behaviours and anthropometry; (ii) culturally tailored, community-embedded programs enhanced engagement and health literacy; (iii) early childhood and family-focused approaches showed promise; (iv) community or policy initiatives yielded mixed results; and (v) behavioural interventions were ineffective without addressing social and structural determinants. The most effective programs were community-delivered, multi-stakeholder, and centred on empowerment and capacity building. Conclusions: Obesity prevention efforts targeting Aboriginal and Torres Strait Islander children and adolescents are most successful when community-led, culturally grounded, and supported by multiple stakeholders. These findings underscore the necessity of culturally sensitive, participatory approaches. Further research is needed to strengthen the evidence base and inform sustainable, policy-relevant strategies for childhood obesity. Full article

Background/Objectives: Cancer remains a major public health concern in India, with the Northeast Region (NER) reporting the country’s highest incidence rates. In Meghalaya, a predominantly tribal state, cultural beliefs, financial hardship, and limited healthcare access significantly affect cancer diagnosis and treatment outcomes. This study explores the experiences and needs of cancer patients in Meghalaya, India, to inform culturally sensitive, patient-centred, and financially inclusive approaches to cancer care among tribal populations. Methods: A qualitative study was conducted among 19 participants (12 patients and 7 caregivers; in cases where patients were unable to communicate effectively due to physical weakness or treatment-related complications, their primary caregivers, those directly linked to the specific patients, were interviewed instead) receiving treatment at Civil Hospital, Shillong, between August and November 2023. In-depth interviews were conducted in Khasi, translated into English, and analysed thematically following COREQ guidelines. Results: Ten key themes emerged. Patients often attributed early symptoms to supernatural causes and sought traditional healers, delaying diagnosis. Many experienced fragmented care pathways, misinformation, and fear of treatment side effects. The financial burden was severe, with high out-of-pocket costs for travel, diagnostics, and medicines, despite partial relief through the Meghalaya Health Insurance Scheme. Communication about costs between patients and providers was limited, leaving families unprepared for the expenses. Emotional distress, loss of livelihood, and dependence on family support were common, while faith and spirituality served as major coping mechanisms. Conclusions: Cancer care in Meghalaya is shaped by intertwined cultural, economic, and systemic barriers. Strengthening culturally tailored health education, decentralised diagnostic services, structured financial counselling, and cost transparency can improve care delivery. Future research should adopt multi-centre, longitudinal approaches to guide equitable, patient-centred cancer policies in tribal and rural settings. Full article

Background: International and national policies increasingly call for person-centred approaches in disability services, yet little is known about how support intensity needs influence the allocation of resources for individuals with intellectual and developmental disabilities (IDDs). In Italy, where integrated socio-health systems operate within a human rights framework, this quantitative study investigates how individual and contextual factors shape resource use in individualized support planning. Methods: We analyzed data from 1152 adults with IDDs enrolled in 23 service centres across 13 Italian regions. Case managers developed Individualized Support Plans (ISPs) informed by the Supports Intensity Scale and socio-ecological variables. Resource use was measured as weekly counts of adaptive skills training, community participation supports, habilitation services, prosthetics, and assistive technologies. We applied multivariate count models (Sarmanov–Lee) to capture the interdependence across support types. Results: Findings show that gender and level of intellectual functioning did not significantly affect resource allocation. However, individuals with the highest support intensity needs often received fewer supports, particularly in adaptive skills and community participation. Residential settings were associated with higher levels of support provision compared to family or independent living. Assistive technologies and prosthetics were linked with more comprehensive support packages. Conclusions: While person-centred planning frameworks are being implemented, systemic inequities remain, with those at the highest levels of need at risk of receiving fewer enabling supports. Multivariate modelling provides a robust tool for understanding resource use and highlights the importance of equity-focused planning. These findings support policy and practice reforms that operationalize human rights principles and align with the UNCRPD, ensuring more inclusive and responsive systems of support. Full article

Family caregivers provide most daily care for people living with chronic illness or frailty, yet they remain under-recognized in health and social care systems. To address this gap, we co-designed the Caregiver-Centered Care Champions Education Program, which equips frontline providers with the competencies needed to lead caregiver-inclusive change. Guided by the Kirkpatrick-Barr Health Workforce Education Framework, we conducted a mixed methods interpretive description evaluation of learner satisfaction, knowledge and confidence gains, and self-reported behaviour change. Sixty-seven interdisciplinary participants completed three online modules. Quantitative results from pre/post surveys (Wilcoxon signed rank tests) showed significant improvements across all competencies (p < 0.001; large effect sizes) alongside high satisfaction (means 6.56–6.96/7). Qualitative findings revealed that 94% of participants applied program content within three months, and 61% implemented five or more distinct behaviour changes (e.g., collaborative care planning, system navigation support). The analysis illuminated how learners integrated caregiver-centred principles with change leadership strategies. Time constraints and staffing shortages emerged as key barriers. Our co-designed, theory-informed approach effectively bridged individual learning and system change, demonstrating the potential to transform caregiver inclusion practices when supported by organizational policies. Full article