Search Results (5,630)

Dysphagia and age-related oral processing limitations are rising with population aging and the growing burden of neurological diseases. Texture-modified diets remain the most common non-pharmacological intervention, yet conventional pureeing and thickening often yield meals with low visual appeal, variable textures, and diluted nutrient density, which contribute to reduced intake and malnutrition risk. Extrusion-based three-dimensional food printing, especially when combined with gel-derived edible inks, offers a digital route to standardize geometry, portioning, and texture while enabling individualized nutrition and sensory design. In the past three years, the field has progressed from simple single-ingredient pastes to engineered soft-matter systems including emulsion gels, high-internal-phase emulsion gels, Pickering-stabilized gels, bigels, and multi-material constructs enabled by dual and coaxial printing. These advances are underpinned by improved rheological windowing, microstructure engineering, and post-print gelation strategies such as ionic crosslinking, thermal setting, enzymatic bridging, and pH-triggered network formation. Meanwhile, dysphagia-oriented product development has matured from “shape recovery” demonstrations toward clinically relevant texture targets, leveraging the IDDSI tests to anchor swallowability. This review synthesizes the recent literature across materials science, food engineering, and clinical nutrition to connect gel microstructure to extrusion performance, post-processing stability, and oral processing outcomes that are relevant to older adults and dysphagia patients. We propose design principles for gel network selection, phase structuring, and process control that simultaneously satisfy print fidelity and swallowing safety targets. Full article

In response to the pressing issues of unclear adhesion mechanisms during the soil-removal process in peanut harvesting, poor soil fragmentation quality, and difficulties in separating the pods from the soil. Based on TRIZ theory, this study has innovatively designed a separation device that relies on external forces, such as kneading and squeezing. A mechanical model of soil fragmentation and separation was developed. The key factors affecting the device’s operational performance were identified. Through theoretical analysis and discrete element simulation, this study elucidates the working principle by which the device crushes and separates soil particles using kneading and squeezing forces. Through analysis of one-factor and orthogonal experiments, the optimal operating parameter combination for the device was determined to be: a drum installation clearance of 104.7 mm, a rotational speed difference of 75.2 rpm, and a pattern roughness of Grade III (reticulated). The system’s performance metrics are a soil removal rate of 96.59% and a pod damage rate of 2.48%. Field tests have confirmed that the deviation from simulation results is minimal. The device’s performance meets the requirements of actual production. Full article

Objectives: To evaluate extrusion-free survival following glaucoma drainage device (GDD) surgery using EverPatch Plus^® (EPP) and to compare outcomes with conventional scleral patch grafts using propensity score-based survival analysis. Methods: This retrospective case series included 19 eyes that underwent GDD implantation with EPP and 105 control eyes that received conventional scleral patch grafts. To adjust for baseline differences between groups, a propensity score for EPP use was estimated using multivariable logistic regression incorporating age, neovascular glaucoma, prior glaucoma surgery, preoperative intraocular pressure, number of glaucoma medications, quadrant of patch placement, and insertion site. Stabilized inverse probability of treatment weighting was applied. Because follow-up in the EPP group did not exceed 12 months, all survival analyses were performed with administrative censoring at 12 months. Extrusion-free survival was evaluated using Kaplan–Meier analysis and Cox proportional hazards modeling. Results: Within 12 months, patch extrusion occurred in 3 of 19 eyes in the EPP group and in 12 of 105 eyes in the scleral patch graft group. After inverse probability weighting, estimated 12-month extrusion-free survival was 83.5% in the EPP group and 88.4% in the scleral patch graft group, indicating no statistically significant difference between groups (log-rank test, p = 0.498). In an inverse probability-weighted Cox model, EPP use was not significantly associated with extrusion risk (hazard ratio ≈ 1.3; 95% confidence interval ≈ 0.4–4.0). Conclusions: After adjustment for baseline covariates and restriction of follow-up to 12 months, extrusion-free survival following glaucoma drainage device surgery using EPP was comparable to that achieved with conventional scleral patch grafts. Full article

Material extrusion (MEX) additive manufacturing can produce material-dependent variations in dimensional fidelity, internal structure, and deposition stability, even under identical processing conditions. In this study, a comprehensive experimental investigation is conducted on MEX-printed specimens manufactured from a broad set of PLA-based composite materials to quantify these variations and assess their mutual interdependence. Dimensional behavior, internal structural characteristics, and process behavior were systematically investigated using complementary geometric, physical, and deposition-related descriptors. All properties were determined from replicated specimens to ensure statistical robustness, and the resulting datasets were examined using both conventional metrics and multivariate 3D correlation approaches. Compact PLA-based formulations exhibit consistent internal packing, characterized by relative density (RD) values of approximately 0.40–0.46, porosity (ϕ) levels around 55–60%, reduced (≤0.15%) density variability (CV), and small (−0.4–0.0%) volumetric deviations (ΔV). These features reflect stable extrusion and predictable dimensional response. In contrast, foamed, fiber-reinforced, and organic-filled composites display reduced internal packing (RD < 0.40), increased ϕ (>60%), elevated CV (0.27–0.58%), and systematically larger positive ΔV (up to +1.4%), indicating a higher sensitivity to process-induced heterogeneity. Multivariate correlations further reveal that volumetric dimensional distortion is jointly governed by internal packing efficiency and extrusion stability. Overall, the results demonstrate that dimensional accuracy in MEX of PLA-based composites arises from coupled structure–process interactions rather than isolated material or process parameters. The experimental framework proposed here provides quantitative guidance for material selection and process optimization aimed at enhancing geometric fidelity in composite filament fabrication. Full article

Dental tissue regeneration, particularly alveolar bone and gingival repair, remains a major challenge in regenerative medicine. 3D bioprinting offers patient-specific and anatomically precise constructs, representing an advanced alternative to conventional grafting. In this study, nanohydroxyapatite (nHA), chitosan (CS), and collagen (CoL) were combined to fabricate and characterize 3D bioprinted dental grafts. SEM revealed a highly porous, interconnected architecture favorable for cell infiltration and nutrient exchange. EDS confirmed Ca/P ratios of 2.06 for nHA/CoL and 1.83 for nHA/CS/CoL, both of which are above the stoichiometric 1.67, indicating the presence of additional mineral phases and ion substitutions. FTIR and XRD verified characteristic functional groups and crystalline phases, including B-type HA with carbonate substitution. Mechanical testing showed that pure nHA exhibited the lowest compressive strength, whereas CoL incorporation improved stiffness. The nHA/CS/CoL composite achieved the highest compressive strength, elastic modulus, and toughness, demonstrating superior mechanical resilience. DSC analysis indicated endothermic peaks at 106.49 °C and 351.91 °C, with enthalpy values (264.91 J/g and 15.09 J/g) surpassing those of nHA alone. TGA revealed ~28.8% weight loss across three degradation stages, confirming enhanced thermal stability. In vitro cytocompatibility testing using L929 fibroblasts validated the biocompatibility of the composites. Collectively, the synergy between bioceramics and biopolymers markedly improved both mechanical and thermal performance. These findings position the nHA/CS/CoL scaffold as a promising candidate for clinical applications in dental tissue regeneration. Unlike conventional grafting materials, this study introduces a synergistically optimized nHA/CS/CoL bio-ink formulation specifically designed for extrusion-based 3D bioprinting of patient-specific dental constructs. The core innovation lies in the precise integration of nHA within a dual-polymer matrix (CS/CoL), which bridges the gap between mechanical resilience and biological signaling, achieving a compressive strength that mimics native alveolar bone while maintaining high cytocompatibility. Full article

This study aims to develop and characterize novel dermatocosmetic formulations designed to hydrate the skin, improve its appearance, reduce wrinkles, and provide antioxidant, anti-ageing, antimicrobial, and anti-inflammatory benefits, along with potential protection against UVA and UVB radiation. The formulations contain the following ingredients: xanthan gum (0.5%), Calendula officinalis oil (5%), Argania spinosa oil (5%), Helianthus annuus oil (5%), liposomes containing a hydroalcoholic extract of pomace from local red or white grapes (2%), an olive oil-based emulsifier (6%), vitamin E (0.5%), cetearyl alcohol (3%), propylene glycol (8%), and purified water (up to 100%). The natural ingredients used in these formulations, i.e., the red or white grape pomace extract from the aforementioned Romanian varieties, the oils of Calendula officinalis, Argania spinosa, and Helianthus annuus, xanthan gum, and the olive oil-based emulsifier (Olliva), promote the concept of ‘green cosmetics’. The use of liposomes to deliver bioactive substances from hydroalcoholic extracts allows the gradual release of active ingredients into the skin. An alternative for incorporating grape pomace extract into a cream-type matrix involves the use of liposomes. Liposomes loaded with red or white grape pomace extract were prepared using the thin-film hydration technique, followed by ultrasonication and extrusion. The obtained formulations were characterized using bio-physico-chemical analysis procedures in terms of consistency, colour, homogeneity, aroma, pH, stretch, texture, stability, and antioxidant activity/free radical scavenging capacity, as well as in vitro polyphenol release behaviour. These newly developed dermatocosmetic formulations were the subject of a patent application in Romania. Full article

This study investigates the effects of organic salts, including sodium citrate (SC), calcium citrate (CC), and calcium lactate (CL), on the structure–property–function relationships of thermoplastic starch/poly(butylene adipate-co-terephthalate) (TPS/PBAT) films for active packaging applications. TPS incorporated with organic salts was prepared via twin-screw extrusion, blended with PBAT, and further processed into blown films. The films were systematically characterized using ¹H NMR, FTIR, and SEM, together with optical, mechanical, water vapor permeability, and antimicrobial evaluations against Staphylococcus aureus. The results revealed that SC primarily modulated hydrogen-bonding interactions within the starch matrix, resulting in improved structural homogeneity, balanced mechanical properties, and the highest antimicrobial activity among all formulations. In contrast, CL and CC promoted ionic crosslinking through Ca²⁺–starch interactions, leading to increased stiffness and Young’s modulus but reduced polymer chain mobility and limited release of active species, particularly in CC-containing systems. These differences in molecular interactions were consistent with variations in film microstructure, where SC-containing films exhibited more uniform morphologies, while calcium-based systems showed denser but less permeable structures. Furthermore, films containing SC and CL at appropriate concentrations achieved a favorable balance between transparency, water vapor barrier properties, and antimicrobial performance. Overall, this study provides new mechanistic insights into how monovalent and divalent organic salts govern intermolecular interactions, microstructure, and functional performance in TPS/PBAT systems. The findings highlight the critical role of additive type and concentration in designing biodegradable active packaging materials with tunable mechanical, barrier, and antimicrobial properties. Full article

The shift toward lightweight powertrain architectures necessitates a detailed characterization of polymer gears to verify their efficiency and durability. This study investigated the effectiveness of non-contact structured-light 3D scanning for evaluating the surface topography and dimensional tolerance quality of polymer gears produced via distinct manufacturing technologies. A structured-light 3D scanner was used to capture dense point clouds (exceeding 6 million points) of gears produced by three methods: conventional hobbing (POM-C), Material Extrusion (MEX) with carbon fiber reinforcement, and Selective Laser Sintering (SLS). The manufactured parts were compared against the nominal Computer Aided Design (CAD) models to evaluate their geometrical deviations in accordance with DIN 3961 and surface roughness parameters per ISO 25178. The experimental results revealed a consistent ranking of manufacturing quality. The conventionally hobbed POM-C gear exhibited superior precision, achieving DIN quality grades of Q9–Q10 and the smoothest surface finish (S_a = 5.0 µm). Among additive manufacturing techniques, SLS-printed PA 12 showed intermediate quality (Q11, S_a = 12 µm), whereas MEX-printed PPS-CF exhibited significant deviations (exceeding Q12) and the highest surface irregularity (S_a = 25 µm) due to stair-stepping effects. These findings indicate that while additive manufacturing offers geometric flexibility, conventional hobbing retains a decisive advantage in dimensional precision. The optical scanning methodology demonstrated here constitutes an efficient metrological framework for gear quality control, with potential applications extending to the quality assurance of additively manufactured adaptive fixtures and assembly tooling, including automotive assembly operations. Full article

Background/Objectives: Medial meniscus extrusion (MME) is a quantitative marker of altered meniscal containment and load sharing. Although ultrasonography enables dynamic assessment under functional loading, it remains unclear whether generalized ligamentous hypermobility influences physiologic extrusion behavior in healthy knees. The aim of this study was to quantify load-dependent MME in healthy adults and to determine whether generalized hypermobility is associated with greater physiologic extrusion under progressive loading conditions. Methods: In this prospective observational study, 106 healthy adults aged 18–40 years were evaluated between October and December 2025. Generalized joint hypermobility was defined as a Beighton score ≥5. MME was measured by standardized ultrasonography on the dominant limb in three conditions: sitting (unloaded), bipedal stance, and unipedal stance. Patellar tendon shear-wave elastography (SWE) was recorded in kilopascals (kPa). Interobserver reliability was assessed in the first 25 participants using ICC (2,1). Group comparisons, multivariable linear regression for loading-related Δ-extrusion (Unipedal−Sitting and Bipedal−Sitting), and a linear mixed-effects model for repeated MME measures, including a Position × Hypermobility interaction, were performed. Results: Twenty-eight participants (26.4%) were classified as hypermobile. The hypermobile group showed significantly lower patellar tendon SWE than controls (23.8 ± 7.0 vs. 37.6 ± 9.7 kPa, p < 0.001). MME increased stepwise with loading in both groups and remained consistently higher in hypermobile participants across sitting, bipedal, and unipedal conditions (all p < 0.001). Loading-related extrusion was also greater in the hypermobile group for both Bipedal−Sitting (p = 0.037) and Unipedal−Sitting (p = 0.002). In multivariable regression, lower patellar tendon SWE independently predicted greater loading-related extrusion, whereas hypermobility status did not remain an independent predictor. In the mixed model, the Position × Hypermobility interaction was significant and was most pronounced during the unipedal stance. Conclusions: In healthy adults, medial meniscus extrusion increases stepwise from unloaded sitting to bipedal and unipedal weight bearing. Participants with generalized hypermobility demonstrated higher physiologic MME values and a more pronounced load-dependent pattern, particularly during unipedal stance. However, in adjusted analyses, lower patellar tendon stiffness on SWE, rather than hypermobility status itself, independently predicted greater loading-related extrusion. These findings support a contextual interpretation of ultrasound-based MME measurements in relation to loading condition and hypermobility phenotype. Full article

The study focused on the development and optimization of plastic deformation of pure M1E copper using an unconventional hydrostatic extrusion (HE) process aimed at improving the performance of electrodes used in electrical discharge machining (EDM). The process was designed to refine the microstructure while maintaining the high electrical conductivity required for EDM applications. Optimization of a three-stage HE process (cumulative strain ε = 2.51) resulted in the formation of an ultrafine-grained structure (d₂ ≈ 370 nm), leading to a significant increase in mechanical strength (UTS ≈ 400 MPa) while preserving very high electrical conductivity (~99% IACS). This combination of properties is particularly important for EDM electrodes, as it allows improved wear resistance without compromising electrical performance. Due to the application-oriented nature of the study, the HE-processed copper was tested under industrial EDM conditions. Wear tests were conducted using seven electrodes of different geometries required for the production of a sample injection mold. The results demonstrated a substantial reduction in electroerosion wear of HE-processed electrodes (30–90%) compared with undeformed copper, together with up to 25% improvement in surface quality. These findings indicate that hydrostatic extrusion is an effective method for producing high performance EDM electrode materials with improved durability and machining quality. Full article

The successful application of 3D and 4D food printing is fundamentally governed by the rheology and microstructure of edible inks. These factors control every step, from extrusion and nozzle deposition to the final product functionality. This review systematically examines how formulation variables, including starch/protein composition, water content, and hydrocolloids, determine the network architecture and critical rheological properties, such as yield stress and viscoelasticity. These properties determine printing outcomes such as filament formation, stacking accuracy, and the stability of sensitive components. This review explores 4D printing as a “3D + 1D function,” where printed structures provide additional features over time, such as a controlled color change or bioactive release, while post-printing treatment often activates these features. Through case studies of novel inks, we show how interfacial chemistry and process parameters influence texture and stability. Finally, we discuss the application of rheological metrics for predicting printability and outline the critical need for developing multi-parameter, process-relevant printability indices to advance the field of digital food manufacturing. Full article

Sustainable nanotechnologies derived from renewable resources are increasingly being positioned at the interface of green chemistry, advanced drug delivery, and translational pharmaceutics. Over the past decade, lignocellulosic nanomaterials, chitin/chitosan platforms, polysaccharide-based nanogels and nano-enabled hydrogels, lignin- and polyphenol-derived nanostructures, and bio-based lipid nanocarriers have been engineered through progressively eco-efficient routes, including solvent-minimized self-assembly, nanoprecipitation, spray drying, hot-melt extrusion, and microfluidic-assisted fabrication. This work provides a structured evidence map of nano-enabled drug delivery and therapeutic platforms derived from renewable biological resources. Specifically, we aim to (i) identify and classify nanoplatform classes and renewable feedstocks; (ii) summarize reported pharmaceutical critical quality attributes (CQAs) and performance and safety endpoints; and (iii) appraise how “renewability” and “green” claims are evidenced (feedstock origin vs. process sustainability) and how frequently translational readiness factors (scalability, quality control, regulatory alignment) are addressed. We critically compare renewable and conventional nanomaterial platforms across key translational dimensions, including carbon footprint, batch consistency, biodegradability, functional tunability, safety/persistence, and scale-up maturity. Finally, we delineate a practical translational pathway—from biomass sourcing and fractionation to nanoformulation, characterization/stability, and GMP scale-up—highlighting cross-cutting enablers such as lifecycle assessment, EHS/toxicology risk assessment, quality-by-design, and regulatory alignment. Collectively, the evidence supports renewable nanomaterials as viable, scalable candidates for next-generation therapeutics, provided that variability control, standardized characterization, and safety-by-design principles are embedded early in development. Full article

Texture-modified foods (TMFs) are essential for individuals with dysphagia, yet conventional formulations often lack structural consistency, nutritional density, and sensory appeal. Three-dimensional (3D) food printing offers new opportunities to tailor texture and composition. This study developed 3D-printed TMFs based on a lentil-carrot matrix and formulated with pea protein isolate (PPI), a curcumin-enriched oleogel (O), or their combination (PPI–O), and compared them with a commercial dysphagia thickener reference. Printability was assessed through extrusion force measurements and dimensional deviation analysis. Texture profile analysis (TPA), International Dysphagia Diet Standardisation Initiative (IDDSI) tests, moisture and protein content determination, color measurements, and preliminary sensory evaluation were conducted. PPI-containing formulations required higher extrusion forces but showed improved dimensional stability, hardness, cohesiveness, and gumminess compared with the oleogel-only sample, likely due to the formation of a stronger protein network. In contrast, the oleogel-only formulation exhibited lower mechanical resistance and a more pronounced melting perception, reflecting the lubricating effect of the lipid-based matrix. Protein content significantly increased with PPI incorporation, and curcumin-enriched oleogel also markedly influenced color parameters. All samples were classified as compatible with IDDSI Level 5. The hybrid PPI–O formulation provided a balanced combination of printability, structural fidelity, enhanced protein content, and suitable textural properties. These findings suggest that extrusion-based 3D printing may represent a promising approach for designing plant-based TMFs for dysphagia-oriented foods. Full article

Background/Objectives: This finite element analysis (FEA) assessed stress distribution in the tooth and dentin within an intact periodontium under 4 N of force and five orthodontic movements (intrusion, extrusion, rotation, tipping, and translation), using four failure criteria commonly used in numerical dental studies. Secondly, differences between brittle- and ductile-like failure criteria were found, and the most accurate criterion was determined. Additionally, movements more prone to inducing external orthodontic root resorption were assessed. Methods: Using nine 3D models of the second lower premolar, 180 numerical simulations were performed. The models were anatomically accurate based on CBCT scans. FEA employed the brittle-like Maximum Principal (MaxP), Minimum Principal (MinP), and ductile-like Von Mises (VM) and Tresca (T). Results: The results showed that tipping was less prone to external orthodontic root resorption than translation, extrusion, intrusion, and rotation, which showed areas of high stress concentration in the cervical third of the root. High-stress areas were visible only when the dentin-pulp-NVB components were separately analyzed, and not when the entire tooth structure was assessed. Only by correlating the qualitative with the quantitative results could the difference between brittle-like and ductile-like failure criteria be seen. Conclusions: In total, 4 N of applied orthodontic force can induce limited islands of external orthodontic root resorption (intrusion–extrusion on the vestibular side, rotation–translation on the lingual and distal–lingual sides). The ductile-like failure criteria maintained the accuracy of the results across all FEA simulations, while the brittle-like criteria showed various quantitative and qualitative inconsistencies. Full article

Objectives: This study aimed to analyze the three-dimensional displacement of maxillary first molars using a finite element model with two headgear configurations, namely cervical and horizontal pull headgears, as well as pendulum, infrazygomatic miniscrews, Bollard miniplates, Advanced Molar Distalization Appliance (AMDA), and Beneslider. The goal was to clarify how variations in anchorage design and force direction influence molar movement across the sagittal, vertical, and transverse planes. Methods: A three-dimensional finite element model of the maxillary dentition and supporting structures was constructed using reference anatomical data and standardized material properties. Each appliance was virtually simulated under its clinically recommended force magnitude and direction to ensure realistic biomechanical conditions. The orientation of each force vector relative to the molar’s center of resistance (CR) was analyzed, and resulting tooth displacements were quantified along the sagittal (Z), vertical (Y), and transverse (X) axes using 49-node reference paths connecting key anatomical landmarks. Results: Appliances applying forces through or above the molar CR, such as the AMDA, infrazygomatic miniscrews, and Bollard miniplates, produced nearly bodily distalization with minimal tipping (<0.6° (range 0.3–0.6°)) and slight intrusion (−0.12 to −0.18 mm). Conversely, systems delivering forces below the CR, such as the cervical headgear and pendulum, resulted in greater crown tipping and extrusion. The Beneslider exhibited an intermediate displacement pattern with moderate vertical control. Conclusions: Force vector height and direction relative to the molar CR critically determine 3D displacement behavior. Skeletal anchorage and adjustable systems, particularly the AMDA, demonstrated the most controlled distalization pattern with minimal tipping, whereas conventional tooth-borne designs induced more tipping and extrusion. Full article