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Search Results (709)

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Keywords = evaporation cooling

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50 pages, 9033 KiB  
Article
Heat Pipe Integrated Cooling System of 4680 Lithium–Ion Battery for Electric Vehicles
by Yong-Jun Lee, Tae-Gue Park, Chan-Ho Park, Su-Jong Kim, Ji-Su Lee and Seok-Ho Rhi
Energies 2025, 18(15), 4132; https://doi.org/10.3390/en18154132 - 4 Aug 2025
Abstract
This study investigates a novel heat pipe integrated cooling system designed for thermal management of Tesla’s 4680 cylindrical lithium–ion batteries in electric vehicles (EVs). Through a comprehensive approach combining experimental analysis, 1-D AMESim simulations, and 3-D Computational Fluid Dynamics (CFD) modeling, the thermal [...] Read more.
This study investigates a novel heat pipe integrated cooling system designed for thermal management of Tesla’s 4680 cylindrical lithium–ion batteries in electric vehicles (EVs). Through a comprehensive approach combining experimental analysis, 1-D AMESim simulations, and 3-D Computational Fluid Dynamics (CFD) modeling, the thermal performance of various wick structures and working fluid filling ratios was evaluated. The experimental setup utilized a triangular prism chamber housing three surrogate heater blocks to replicate the heat generation of 4680 cells under 1C, 2C, and 3C discharge rates. Results demonstrated that a blended fabric wick with a crown-shaped design (Wick 5) at a 30–40% filling ratio achieved the lowest maximum temperature (Tmax of 47.0°C), minimal surface temperature deviation (ΔTsurface of 2.8°C), and optimal thermal resistance (Rth of 0.27°C/W) under 85 W heat input. CFD simulations validated experimental findings, confirming stable evaporation–condensation circulation at a 40% filling ratio, while identifying thermal limits at high heat loads (155 W). The proposed hybrid battery thermal management system (BTMS) offers significant potential for enhancing the performance and safety of high-energy density EV batteries. This research provides a foundation for optimizing thermal management in next-generation electric vehicles. Full article
(This article belongs to the Special Issue Optimized Energy Management Technology for Electric Vehicle)
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19 pages, 4156 KiB  
Article
Experimental and Numerical Analyses of Diameter Reduction via Laser Turning with Respect to Laser Parameters
by Emin O. Bastekeli, Haci A. Tasdemir, Adil Yucel and Buse Ortac Bastekeli
J. Manuf. Mater. Process. 2025, 9(8), 258; https://doi.org/10.3390/jmmp9080258 - 1 Aug 2025
Viewed by 124
Abstract
In this study, a novel direct laser beam turning (DLBT) approach is proposed for the precision machining of AISI 308L austenitic stainless steel, which eliminates the need for cutting tools and thereby eradicates tool wear and vibration-induced surface irregularities. A nanosecond-pulsed Nd:YAG fiber [...] Read more.
In this study, a novel direct laser beam turning (DLBT) approach is proposed for the precision machining of AISI 308L austenitic stainless steel, which eliminates the need for cutting tools and thereby eradicates tool wear and vibration-induced surface irregularities. A nanosecond-pulsed Nd:YAG fiber laser (λ = 1064 nm, spot size = 0.05 mm) was used, and Ø1.6 mm × 20 mm cylindrical rods were processed under ambient conditions without auxiliary cooling. The experimental framework systematically evaluated the influence of scanning speed, pulse frequency, and the number of laser passes on dimensional accuracy and material removal efficiency. The results indicate that a maximum diameter reduction of 0.271 mm was achieved at a scanning speed of 3200 mm/s and 50 kHz, whereas 0.195 mm was attained at 6400 mm/s and 200 kHz. A robust second-order polynomial correlation (R2 = 0.99) was established between diameter reduction and the number of passes, revealing the high predictability of the process. Crucially, when the scanning speed was doubled, the effective fluence was halved, considerably influencing the ablation characteristics. Despite the low fluence, evidence of material evaporation at elevated frequencies due to the incubation effect underscores the complex photothermal dynamics governing the process. This work constitutes the first comprehensive quantification of pass-dependent diameter modulation in DLBT and introduces a transformative, noncontact micromachining strategy for hard-to-machine alloys. The demonstrated precision, repeatability, and thermal control position DLBT as a promising candidate for next-generation manufacturing of high-performance miniaturized components. Full article
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25 pages, 2474 KiB  
Article
Performance Analysis of a Novel Directly Combined Organic Rankine Cycle and Dual-Evaporator Vapor Compression Refrigeration Cycle
by Nagihan Bilir Sag and Metehan Isik
Appl. Sci. 2025, 15(15), 8545; https://doi.org/10.3390/app15158545 (registering DOI) - 31 Jul 2025
Viewed by 172
Abstract
Combining Organic Rankine Cycles (ORC) with cooling cycles offers a promising approach to achieving greater outputs within a single system. In this study, a novel directly combined ORC-VCC system has been designed to not only meet the cooling demand using a geothermal heat [...] Read more.
Combining Organic Rankine Cycles (ORC) with cooling cycles offers a promising approach to achieving greater outputs within a single system. In this study, a novel directly combined ORC-VCC system has been designed to not only meet the cooling demand using a geothermal heat source but also generate power. The proposed novel ORC-VCC system has been analyzed for its energetic performance using four selected fluids: R290, R600a, R601, and R1234ze(E). Parametric analysis has been conducted to investigate the effects of parameters of heat source temperature, heat source mass flow rate, cooling capacities, condenser temperature, ORC evaporator temperature, pinch point temperature difference and isentropic efficiencies on net power production. Among the working fluids, R290 has provided the highest net power production under all conditions in which it was available to operate. Additionally, the results have been analyzed concerning a reference cycle for comparative evaluation. The proposed novel cycle has outperformed the reference cycle in all investigated cases in terms of net power production such as demonstrating an improvement of approximately from 8.7% to 57.8% in geothermal heat source temperature investigations. Similar improvements have been observed over the reference cycle at lower heat source mass flow rates, where net power increases by up to 50.8%. Full article
(This article belongs to the Section Mechanical Engineering)
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16 pages, 3079 KiB  
Article
Optimized Solar-Powered Evaporative-Cooled UFAD System for Sustainable Thermal Comfort: A Case Study in Riyadh, KSA
by Mohamad Kanaan, Semaan Amine and Mohamed Hmadi
Thermo 2025, 5(3), 26; https://doi.org/10.3390/thermo5030026 - 30 Jul 2025
Viewed by 306
Abstract
Evaporative cooling (EC) offers an energy-efficient alternative to direct expansion (DX) cooling but suffers from high water consumption. This limitation can be mitigated by pre-cooling incoming fresh air using cooler exhaust air via energy recovery. This study presents and optimizes a solar-driven EC [...] Read more.
Evaporative cooling (EC) offers an energy-efficient alternative to direct expansion (DX) cooling but suffers from high water consumption. This limitation can be mitigated by pre-cooling incoming fresh air using cooler exhaust air via energy recovery. This study presents and optimizes a solar-driven EC system integrated with underfloor air distribution (UFAD) to enhance thermal comfort and minimize water use in a temporary office in Riyadh’s arid climate. A 3D CFD model was developed and validated against published data to simulate indoor airflow, providing data for thermal comfort evaluation using the predicted mean vote model in cases with and without energy recovery. A year-round hourly energy analysis revealed that the solar-driven EC-UFAD system reduces grid power consumption by 93.5% compared to DX-based UFAD under identical conditions. Energy recovery further cuts annual EC water usage by up to 31.3%. Operational costs decreased by 84% without recovery and 87% with recovery versus DX-UFAD. Full article
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22 pages, 3165 KiB  
Article
Efficiency Enhancement of Photovoltaic Panels via Air, Water, and Porous Media Cooling Methods: Thermal–Electrical Modeling
by Brahim Menacer, Nour El Houda Baghdous, Sunny Narayan, Moaz Al-lehaibi, Liomnis Osorio and Víctor Tuninetti
Sustainability 2025, 17(14), 6559; https://doi.org/10.3390/su17146559 - 18 Jul 2025
Viewed by 473
Abstract
Improving photovoltaic (PV) panel performance under extreme climatic conditions is critical for advancing sustainable energy systems. In hyper-arid regions, elevated operating temperatures significantly reduce panel efficiency. This study investigates and compares three cooling techniques—air cooling, water cooling, and porous media cooling—using thermal and [...] Read more.
Improving photovoltaic (PV) panel performance under extreme climatic conditions is critical for advancing sustainable energy systems. In hyper-arid regions, elevated operating temperatures significantly reduce panel efficiency. This study investigates and compares three cooling techniques—air cooling, water cooling, and porous media cooling—using thermal and electrical modeling based on CFD simulations in ANSYS. The numerical model replicates a PV system operating under peak solar irradiance (900 W/m2) and realistic ambient conditions in Adrar, Algeria. Simulation results show that air cooling leads to a modest temperature reduction of 6 °C and a marginal efficiency gain of 0.25%. Water cooling, employing a top-down laminar flow, reduces cell temperature by over 35 °C and improves net electrical output by 30.9%, despite pump energy consumption. Porous media cooling, leveraging passive evaporation through gravel, decreases panel temperature by around 30 °C and achieves a net output gain of 26.3%. Mesh sensitivity and validation against experimental data support the accuracy of the model. These findings highlight the significant potential of water and porous material cooling strategies to enhance PV performance in hyper-arid environments. The study also demonstrates that porous media can deliver high thermal effectiveness with minimal energy input, making it a suitable low-cost option for off-grid applications. Future work will integrate long-term climate data, real diffuser geometries, and experimental validation to further refine these models. Full article
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19 pages, 2695 KiB  
Article
Experimental Study of an Evaporative Cooling System in a Rotating Vertical Channel with a Circular Cross-Section for Large Hydro-Generators
by Ruiwei Li and Lin Ruan
Energies 2025, 18(14), 3681; https://doi.org/10.3390/en18143681 - 12 Jul 2025
Viewed by 288
Abstract
With the evolution of hydroelectric generators toward larger capacity and higher rotational speeds, the significa++nt increase in power density has rendered rotor cooling technology a critical bottleneck restricting performance enhancement. Addressing the need for feasibility verification and thermodynamic characteristic analysis of evaporative cooling [...] Read more.
With the evolution of hydroelectric generators toward larger capacity and higher rotational speeds, the significa++nt increase in power density has rendered rotor cooling technology a critical bottleneck restricting performance enhancement. Addressing the need for feasibility verification and thermodynamic characteristic analysis of evaporative cooling applied to rotors, this study innovatively proposes an internal-cooling-based evaporative cooling architecture for rotor windings. By establishing a single-channel experimental platform for a rotor evaporative cooling system, the key parameters of the system circulation flow under varying centrifugal accelerations and thermal loads are obtained, revealing the flow mechanism of the cooling system. The experimental results demonstrate that the novel architecture has outstanding heat dissipation performance. Furthermore, the experimental findings reveal that the flow characteristics of the medium are governed by the coupled effect of centrifugal acceleration and thermal load; the flow rate decreases with increasing centrifugal acceleration and increases with rising thermal load. Centrifugal acceleration reduces frictional losses in the heating pipe, leading to a decrease in the inlet–outlet pressure difference. Through the integration of experimental data with classic formulas, this study refines the friction factor model, with the modified formula showing a discrepancy of −10% to +5% compared with the experimental results. Finally, the experiment was rerun to verify the universality of the modified friction factor. Full article
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42 pages, 4568 KiB  
Review
Comprehensive Review on Evaporative Cooling and Desiccant Dehumidification Technologies for Agricultural Greenhouses
by Fakhar Abbas, Muhammad Sultan, Muhammad Wakil Shahzad, Muhammad Farooq, Hafiz M. U. Raza, Muhammad Hamid Mahmood, Uzair Sajjad and Zhaoli Zhang
AgriEngineering 2025, 7(7), 222; https://doi.org/10.3390/agriengineering7070222 - 8 Jul 2025
Viewed by 1374
Abstract
Greenhouses are crucial for maintaining an ideal temperature and humidity level for plant growth; however, attaining ideal levels remains a challenge. Energy-efficient and sustainable alternatives are needed because traditional temperature/humidity control practices and vapor compression air conditioning systems depend on climate conditions and [...] Read more.
Greenhouses are crucial for maintaining an ideal temperature and humidity level for plant growth; however, attaining ideal levels remains a challenge. Energy-efficient and sustainable alternatives are needed because traditional temperature/humidity control practices and vapor compression air conditioning systems depend on climate conditions and harmful refrigerants. Advanced alternative technologies like evaporative cooling and desiccant dehumidification have emerged that maintain the ideal greenhouse temperature and humidity while using the least amount of energy. This study reviews direct evaporative cooling, indirect evaporative cooling, and Maisotsenko-cycle evaporative cooling (MEC) systems and solid and liquid desiccant dehumidification systems. In addition, integrated desiccant and evaporative cooling systems and hybrid systems are reviewed in this study. The results show that the MEC system effectively reduces the ambient temperature up to the ideal range while maintaining the humidity ratio, and both dehumidification systems effectively reduce the humidity level and improve evaporative cooling efficiency. The integrated systems and hybrid systems have the ability to increase energy efficiency and controlled climatic stability in greenhouses. Regular maintenance, initial system cost, economic feasibility, and system scalability are significant challenges to implement these advanced temperature and humidity control systems for greenhouses. These findings will assist agricultural practitioners, engineers, and researchers in seeking alternate efficient cooling methods for greenhouse applications. Future research directions are suggested to manufacture high-efficiency, low-energy consumption, and efficient greenhouse temperature control systems while considering the present challenges. Full article
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26 pages, 2757 KiB  
Article
Comparative Life Cycle Analysis for Duct Air Conditioning Systems Based on Evaporative and Vapor Compression Technologies
by Andrzej Marcinkowski and Dmytro Levchenko
Energies 2025, 18(13), 3475; https://doi.org/10.3390/en18133475 - 1 Jul 2025
Viewed by 394
Abstract
The environmental impact of innovative indirect regenerative evaporative cooling (IREC) technology is analyzed using the life cycle assessment. This study compared typical equipment using this technology from Innovative Ideas LLC with available-on-the-market traditional vapor compression ducted air conditioning systems as the closest analogous [...] Read more.
The environmental impact of innovative indirect regenerative evaporative cooling (IREC) technology is analyzed using the life cycle assessment. This study compared typical equipment using this technology from Innovative Ideas LLC with available-on-the-market traditional vapor compression ducted air conditioning systems as the closest analogous representatives of the vapor compression technology. For comparison, units with the same cooling capacity (5 kW) were selected. The endpoint indicators demonstrated that the air conditioning systems using IREC technology had lower environmental load compared to the vapor compression system by 29–70%, depending on the scenario and damage category. This advantage resulted from the significantly higher coefficient of performance of the IREC system. The amounts of cooling energy generated and electricity consumption were determined based on temperature and relative humidity data recorded at hourly intervals in the summer seasons of 2023 and 2024. The operation turned out to be a life cycle stage with dominating environmental load. The uncertainty analysis carried out with Monte Carlo simulations indicated significant deviation, particularly for the ecosystem category. The sensitivity analysis showed that the assumed electricity mix did not significantly affect the general conclusions. Full article
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23 pages, 9135 KiB  
Article
Stone Detection on Agricultural Land Using Thermal Imagery from Unmanned Aerial Systems
by Florian Thürkow, Mike Teucher, Detlef Thürkow and Milena Mohri
AgriEngineering 2025, 7(7), 203; https://doi.org/10.3390/agriengineering7070203 - 1 Jul 2025
Viewed by 688
Abstract
Stones in agricultural fields pose a recurring challenge, particularly due to their potential to damage agricultural machinery and disrupt field operations. As modern agriculture moves toward automation and precision farming, efficient stone detection has become a critical concern. This study explores the potential [...] Read more.
Stones in agricultural fields pose a recurring challenge, particularly due to their potential to damage agricultural machinery and disrupt field operations. As modern agriculture moves toward automation and precision farming, efficient stone detection has become a critical concern. This study explores the potential of thermal imaging as a non-invasive method for detecting stones under varying environmental conditions. A series of controlled laboratory experiments and field investigations confirmed the assumption that stones exhibit higher surface temperatures than the surrounding soil, especially when soil moisture is high and air temperatures are cooling rapidly. This temperature difference is attributed to the higher thermal inertia of stones, which allows them to absorb and retain heat longer than soil, as well as to the evaporative cooling from moist soil. These findings demonstrate the viability of thermal cameras as a tool for stone detection in precision farming. Incorporating this technology with GPS mapping enables the generation of accurate location data, facilitating targeted stone removal and reducing equipment damage. This approach aligns with the goals of sustainable agricultural engineering by supporting field automation, minimizing mechanical inefficiencies, and promoting data-driven decisions. Thermal imaging thereby contributes to the evolution of next-generation agricultural systems. Full article
(This article belongs to the Special Issue Recent Trends and Advances in Agricultural Engineering)
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20 pages, 4615 KiB  
Article
Energy Savings Potential of Multipurpose Heat Pumps in Air-Handling Systems
by Eva Schito and Paolo Conti
Energies 2025, 18(13), 3259; https://doi.org/10.3390/en18133259 - 21 Jun 2025
Viewed by 358
Abstract
Multipurpose heat pumps are devices able to provide simultaneously heating and cooling requirements. These devices concurrently provide useful thermal energy at condenser and evaporator with a single electrical energy input, potentially achieving energy savings as heat-recovery and co-generative technology. Despite their potential contribution [...] Read more.
Multipurpose heat pumps are devices able to provide simultaneously heating and cooling requirements. These devices concurrently provide useful thermal energy at condenser and evaporator with a single electrical energy input, potentially achieving energy savings as heat-recovery and co-generative technology. Despite their potential contribution to the energy transition goals as both renewable and energy-efficient technology, their use is not yet widespread. An application example for multipurpose heat pumps is air handlers, where cooling and reheat coils are classically fed by separate thermal generators (i.e., boiler, heat pumps, and chillers). This research aims at presenting the energy potential of multipurpose heat pumps as thermal generators of air handler units, comparing their performances with a classic separate configuration. A museum in the Mediterranean climate is selected as a reference case, as indoor temperature and relative humidity must be continuously controlled by cold and hot coils. The thermal loads at building and air handler level are evaluated through TRNSYS 17 and MATLAB 2022b, through specific dynamic models developed according to manufacturer’s data. An integrated building-HVAC simulation, on the cooling season with a one-hour timestep, demonstrates the advantages of the proposed technology. Indeed, the heating load is almost entirely provided by recovering energy at the condenser, and a 22% energy saving is obtained compared to classic separate generators. Furthermore, a sensitivity analysis confirms that the multipurpose heat pump outperforms separate generation systems across different climates and related loads, with consistently better energy performance due to its adaptability to varying heating and cooling demands. Full article
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9 pages, 1029 KiB  
Article
A Dimensionless Number for Evaluating the Influence of Heat Conduction in the Gas Phase on Liquid Evaporation
by Longfei Xu and Xuefeng Xu
Energies 2025, 18(13), 3233; https://doi.org/10.3390/en18133233 - 20 Jun 2025
Viewed by 236
Abstract
Heat conduction in the gas phase may influence liquid evaporation, yet a quantitative characterization of this effect still remains lacking. Here, through dimensionless analysis of the theoretical model for droplet evaporation, two limiting solutions were obtained for the droplet evaporation considering heat conduction [...] Read more.
Heat conduction in the gas phase may influence liquid evaporation, yet a quantitative characterization of this effect still remains lacking. Here, through dimensionless analysis of the theoretical model for droplet evaporation, two limiting solutions were obtained for the droplet evaporation considering heat conduction in the gas phase. Based on these solutions, a dimensionless number, HCg, was introduced to evaluate the influence of heat conduction in the gas phase on liquid evaporation. Further analysis indicates that HCg is a function of the relative thermal conductivity of the surrounding air, the evaporative cooling number of the liquid, and the contact angle of the droplet. Analytical expressions for both HCg and the droplet evaporation rate were acquired by fitting the numerical simulations. These results show that the effect of gas-phase heat conduction can generally be neglected due to the typically small values of HCg but becomes significant in cases involving atmospheres with higher thermal conductivity, liquids with smaller evaporative cooling numbers, or droplets with larger contact angles. This work may provide a simple yet accurate criterion for estimating the effects of gas-phase heat conduction on liquid evaporation. Full article
(This article belongs to the Section J1: Heat and Mass Transfer)
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19 pages, 6921 KiB  
Article
Drying Performance of Fabrics on the Human Body
by Ivona Jerkovic, Agnes Psikuta, Sahar Ebrahimi, Joyce Baumann, Martin Camenzind, Simon Annaheim and René M. Rossi
Materials 2025, 18(11), 2655; https://doi.org/10.3390/ma18112655 - 5 Jun 2025
Viewed by 550
Abstract
When developing fabrics for applications in which evaporative cooling and drying play an important role, e.g., sports or occupational applications, the drying performance of fabrics is commonly determined using fast and easy-to-perform benchmark methods. The measurement conditions in these methods, however, differ significantly [...] Read more.
When developing fabrics for applications in which evaporative cooling and drying play an important role, e.g., sports or occupational applications, the drying performance of fabrics is commonly determined using fast and easy-to-perform benchmark methods. The measurement conditions in these methods, however, differ significantly from the drying conditions on the human body surface, where drying is obstructed on one side of the fabric through contact with the skin and at the same time enhanced due to contact with the heated surface (skin). The aims of this study were to understand and quantify the fabric drying process at the skin interface considering these real-use effects based on tests applying two-sided drying, one-sided drying, one-sided drying on a heated surface, and one-sided drying on a heated surface in the stretched state, and to relate these to existing standard methods. The findings showed that contact with a solid heated surface such as the skin and the stretched state of the fabric both make a significant contribution (p < 0.05) to the drying rate compared to two-sided drying in standard climatic conditions. The corresponding drying rates observed for a range of typical fabrics used in leisure and sports as a first layer next to the skin were found to be 1.6 (±0.2), 1.1 (±0.2), 7.9 (±2.1), and 10.6 (±0.8) g/m2 min for two-sided drying, one-sided drying, one-sided drying on a heated surface, and one-sided drying on a heated surface in the stretched state, respectively. These findings are of great importance for human thermal modelling, including clothing models, where the drying process significantly contributes to the heat and mass transfer in the skin–clothing–environment system. Full article
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14 pages, 2945 KiB  
Article
A Computational Investigation of the “Equivalent Substrates” in the Evaporation of Sessile Droplets
by Longfei Xu and Xuefeng Xu
Appl. Sci. 2025, 15(11), 6083; https://doi.org/10.3390/app15116083 - 28 May 2025
Viewed by 307
Abstract
This paper investigates the coupled relationship between solid-phase temperature fields and droplet evaporation, focusing on the effects of substrate thermal conduction properties on droplet evaporation behavior. A mathematical model is developed to analyze the impacts of substrate thermal conductivity, thickness, and lower-surface temperature [...] Read more.
This paper investigates the coupled relationship between solid-phase temperature fields and droplet evaporation, focusing on the effects of substrate thermal conduction properties on droplet evaporation behavior. A mathematical model is developed to analyze the impacts of substrate thermal conductivity, thickness, and lower-surface temperature on evaporation rate, surface temperature, and evaporation flux. A dimensionless relative evaporation rate (HCs) is introduced to characterize the influence of substrate thermal conduction. Results show that increasing substrate thermal conductivity enhances droplet surface temperature and evaporation flux, thereby monotonically increasing evaporation rate until it approaches the rate of the evaporative cooling model. Conversely, increasing substrate thickness lengthens the heat transfer path, reducing heat conducted to the solid–liquid interface and decreasing evaporation rate. Changes in substrate lower-surface temperature significantly affect evaporation rate, but HCs remains nearly unaffected. The concept of equivalent substrates is proposed and verified through dimensionless analysis and simulations. It is found that different combinations of substrate thickness and thermal conductivity exhibit consistent effects on droplet evaporation, with minimal relative errors in evaporation rate and total heat transfer at the solid–liquid interface. This confirms the existence of the equivalent substrate phenomenon. Additionally, the effects of droplet properties, such as contact angle and evaporative cooling coefficient (Ec), on the equivalent substrate phenomenon are explored, revealing negligible impacts. These findings provide theoretical guidance for optimizing droplet evaporation processes in practical applications, such as micro/nanoscale thermal management systems. Full article
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14 pages, 616 KiB  
Communication
Application of Solvent Evaporation to Generate Supersaturated Lipid-Based Formulations: Investigation of Drug Load and Formulation Quality
by Felix Paulus, Jef Stappaerts, Annette Bauer-Brandl, Dirk Lauwers, Liesbet Smet, Eline Hermans and René Holm
Pharmaceutics 2025, 17(6), 702; https://doi.org/10.3390/pharmaceutics17060702 - 27 May 2025
Viewed by 474
Abstract
Background/Objectives: Lipid-based formulations (LBFs) are enabling formulations for poorly water-soluble, mostly lipophilic drugs. In LBFs, the drug is pre-dissolved in the formulation which can consist of lipids, surfactants, and/or cosolvents. In cases where the administration of high amounts of a drug is required, [...] Read more.
Background/Objectives: Lipid-based formulations (LBFs) are enabling formulations for poorly water-soluble, mostly lipophilic drugs. In LBFs, the drug is pre-dissolved in the formulation which can consist of lipids, surfactants, and/or cosolvents. In cases where the administration of high amounts of a drug is required, exceeding the drug solubility in the lipidic vehicle at the administration temperature, supersaturated LBFs are an option. The standard method described in the literature for inducing supersaturation in LBFs is to dissolve the drug substance in the lipidic vehicle at an elevated temperature, e.g., at 60 °C, and then subsequently let the formulation cool to ambient temperature before administration (heat-based approach). In this work, an alternative approach to induce supersaturation in LBFs was investigated in order to evaluate if higher drug loads, i.e., the concentration of drug dissolved in the vehicle, could be reached compared to the loading obtainable via heating. Methods: A volatile solvent that is miscible with the lipid matrix and in which the compound has a high solubility is added to the lipid matrix, after which the solvent is evaporated. Both approaches were compared in this work investigating two different LBFs loaded with the BCS-class II drugs celecoxib and fenofibrate. Results: When inducing supersaturation by heat, drug loads of 238% for celecoxib and 278% for fenofibrate could be achieved relative to the solubility at ambient temperature. Using the solvent-based approach, drug loads of up to 475% for celecoxib and 557% for fenofibrate could be prepared in the LBFs using dichloromethane (DCM) as the volatile solvent. However, those highly supersaturated preparations showed suboptimal physical stability and quickly led to precipitation when the LBFs were stored at ambient temperature. In addition, selected formulations were analyzed with GC-headspace to determine the residual DCM after solvent evaporation using a vacuum evaporator. This analysis revealed that the DCM content exceeded regulatory requirements, with up to 21,883 ppm DCM in the formulations. Conclusions: Overall, the relatively high residual DCM concentration and the suboptimal physical stability do not make the approach easily usable for generating supersaturated lipid-based formulations. Full article
(This article belongs to the Special Issue Physical and Chemical Stability of Drug Formulation)
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12 pages, 3793 KiB  
Article
Semi-Annual Climate Modes in the Western Hemisphere
by Mark R. Jury
Climate 2025, 13(6), 111; https://doi.org/10.3390/cli13060111 - 27 May 2025
Viewed by 434
Abstract
Semi-annual climate oscillations in the Western Hemisphere (20 S–35 N, 150 W–20 E) were studied via empirical orthogonal function (EOF) eigenvector loading patterns and principal component time scores from 1980 to 2023. The spatial loading maximum for 850 hPa zonal wind extended from [...] Read more.
Semi-annual climate oscillations in the Western Hemisphere (20 S–35 N, 150 W–20 E) were studied via empirical orthogonal function (EOF) eigenvector loading patterns and principal component time scores from 1980 to 2023. The spatial loading maximum for 850 hPa zonal wind extended from the north Atlantic to the east Pacific; channeling was evident over the southwestern Caribbean. The eigenvector loading maximum for precipitation reflected an equatorial trough, while the semi-annual SST formed a dipole with loading maxima in upwelling zones off Angola (10 E) and Peru (80 W). Weakened Caribbean trade winds and strengthened tropical convection correlated with a warm Atlantic/cool Pacific pattern (R = 0.46). Wavelet spectral analysis of principal component time scores found a persistent 6-month rhythm disrupted only by major El Nino Southern Oscillation events and anomalous mid-latitude conditions associated with negative-phase Arctic Oscillation. Historical climatologies revealed that 6-month cycles of wind, precipitation, and sea temperature were tightly coupled in the Western Hemisphere by heat surplus in the equatorial ocean diffused by meridional overturning Hadley cells. External forcing emerged in early 2010 when warm anomalies over Canada diverted the subtropical jet, suppressing subtropical trade winds and evaporative cooling and intensifying the equatorial trough across the Western Hemisphere. Climatic trends of increased jet-stream instability suggest that the semi-annual amplitude may grow over time. Full article
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