Search Results (22,374)

Bipolar vessel sealing systems are widely used in surgery, yet their effectiveness varies depending on the histological composition of the target vessel. In particular, the influence of elastin on seal stability is not well understood. Porcine carotid arteries, which show a pronounced proximal–distal elastin gradient, provide an ideal model for systematic analysis. In this study, fresh porcine carotid arteries were divided into three segments based on vessel diameter (<5 mm, 5–7 mm, >7 mm). Histological EvG staining was used to quantify elastin and collagen content. All vessels (n = 8 per group) were sealed using a bipolar marSeal^® 5 plus device, followed by burst pressure testing and peel force measurements. Elastin content increased significantly from peripheral to central segments (9% → 25% → 42%; p < 0.001), while collagen content remained constant (22 ± 2%). In parallel, seal stability decreased markedly: burst pressures dropped from 723 mmHg to 240 mmHg and to 31.5 mmHg (p < 0.001). Peel forces showed the same trend (1.75 ± 0.07 N → 0.65 ± 0.03 N → 0.26 ± 0.11 N; p < 0.001). Wall thickness showed no proportional relationship to seal quality. Interestingly, the sealing performance of bipolar systems seems to be greatly influenced by the histological structure of the vessel wall. A high elastin content—rising from 9% to 42% along the carotid artery—was associated with a reduction in burst pressure and peel strength. These findings highlight the need to consider tissue composition when selecting sealing methods and support the development of adaptive energy delivery technologies. Full article

Decarbonization of existing buildings is obstructed by the performance gap between intended and operational energy consumption. Smart energy management and monitoring of existing buildings through digital twins pose significant attributes towards decarbonization efforts. However, there is limited research that transforms digital twins’ monitored performance into actionable retrofitting strategies. Hence, this research develops a framework that bridges the digital twin concept with standards-based IEQ analytics, guiding retrofit decision-making in existing buildings. The framework offers a low-code workflow that uses Autodesk Tandem to develop a digital twin integrating indoor environmental quality (IEQ) data, including thermal comfort and air quality. IEQ is monitored since inefficient management of its parameters often results in excessive HVAC demand, contributing to the performance gap. The framework structures IEQ parameter evaluations against benchmarks guided by ASHRAE to identify deviations indicative of operational inefficiencies in energy consumption. The digital twin model positions live IEQ tracking and analysis as diagnostic measures, leading to targeted fabric-oriented retrofit prioritization. The framework was tested on a case study in a hot arid climate, where its results indicate that the integration of digital twin-based IEQ analysis with building characteristics effectively identified the need for targeted envelope improvements, including high-performance glazing, external shading elements, and sound isolation, as key factors for eliminating overheating and high noise levels. Validating the proposed retrofits’ effectiveness, energy simulations examines the whole building to find an 11.52% annual reduction in energy use intensity from 145.61 kWh/m²·year to 128.84 kWh/m²·year through shading elements and low-E films for glazing. Full article

Chiang Mai, Thailand, experiences seasonal fine particulate matter (PM_2.5) pollution associated with metabolic diseases, but the underlying mechanisms remain unclear. This prospective observational study compared plasma metabolomes of 25 healthy adults in Samoeng District, a highly affected area, between low and high PM_2.5 exposure seasons using proton nuclear magnetic resonance (¹H-NMR) spectroscopy. Twenty-six metabolites differentiating haze and non-haze seasons were identified using PLS-DA (VIP > 1.5). During the haze season, 11 were elevated, whereas 15 were decreased. Among the elevated metabolites, the top five—maleylacetoacetic acid, deoxyribose 5-phosphate, betaine, 3-hydroxyanthranilic acid, and 1-methyladenosine—were associated with inflammation, increased reactive oxygen species, nitric oxide inhibition, and altered amino acid metabolism. The top five decreased metabolites—deoxyguanosine, D-arabitol, glycerophosphocholine, ophthalmic acid, and oxaloacetic acid—were involved in several metabolic pathways, particularly those involved in energy metabolism. A total of 56 metabolic pathways were altered by high PM_2.5 exposure, including pathways related to amino acids, lipids, sugars, nucleotides, vitamins, and energy metabolism. High PM_2.5 exposure disrupts metabolites and pathways, inducing inflammation, oxidative stress, impaired lipid/energy metabolism, insulin resistance, and high blood pressure. These alterations may increase the risk of metabolic and cardiovascular diseases, with dysregulated metabolites serving as potential biomarkers. These findings highlight the molecular impact of air pollution in affected populations and may support preventive strategies and public health policy development in affected regions. Further studies are needed to clarify these findings. Full article

This paper provides a comprehensive review of recent studies on event-triggered control schemes for DC microgrids. Several event-triggered mechanisms (ETMs) are thoroughly discussed, including static, dynamic, self-triggered, and edge-based algorithms. Considering the strengths and weaknesses of these algorithms, it is found that although such ETMs can decrease communication burden in the system, they are also susceptible to communication delays, Zeno behaviour, sensitivity to control parameter changes in triggering conditions, and inability to adapt to the fluctuating nature of renewable energy sources (RESs). Furthermore, this article examines implementation challenges, including data packet loss, quantisation effects, actuator faults, and a lack of cybersecurity measures, to provide readers with a clear vision of future trends in this field. Based on the main findings of the investigation, this review paper proposes possible areas for future research, highlighting the need for event-triggered control schemes that operate in discrete time, handle delays, and adapt to varying operating conditions. Other concepts, including adaptive control parameters for triggering conditions based on machine learning, the adoption of advanced cybersecurity measures, and data-aware transmission approaches that consider both communication frequency and total data volume, are also discussed. To conduct a comprehensive review of all the above-mentioned ETMs, several databases, including IEEE Xplore, Elsevier, and MDPI, were searched using the main keywords in this field, such as event-triggered, self-triggered, and edge-based ETMs, in conjunction with DC microgrids. This facilitated an in-depth analysis of such control schemes, including their strengths and weaknesses, providing readers with a strong basis for selecting a proper control scheme suited to their future research. Full article

This study comprehensively evaluates the mechanical properties, shrinkage behavior, and durability of concrete prepared with limestone- and granite-manufactured sands under standard-curing and steam-curing conditions. The results indicate that limestone-manufactured sand concrete consistently exhibits superior compressive strength and splitting tensile strength across all curing ages, outperforming granite-modified counterparts. The introduction of granite-manufactured sand significantly degrades these mechanical properties, with deterioration intensifying as granite content increases. Dynamic elastic modulus and damping ratio analyses reveal that limestone-based concrete maintains the highest dynamic stiffness and lowest energy dissipation under both curing regimes, suggesting fewer internal defects. In contrast, granite incorporation reduces the dynamic elastic modulus and increases the damping ratio, reflecting structural deterioration and enhanced energy loss. Drying shrinkage tests demonstrate that limestone concrete achieves the lowest shrinkage deformation throughout the testing period, even under steam-curing conditions. Conversely, granite addition markedly elevates shrinkage, particularly under steam-curing conditions, leading to compromised volumetric stability. Durability assessments highlight that manufactured sand concrete exhibits higher capillary absorption, electrical flux, and porosity, attributed to inherent material defects and the surface characteristics of manufactured sand. Granite-modified concrete further weakens interfacial shear strength between aggregates and cement paste, indicating poor interfacial bonding. Steam curing exacerbates microstructural defects, emphasizing the need to optimize curing protocols. The findings propose strategies for enhancing manufactured sand concrete performance: improving interfacial adhesion between aggregates and cement paste, rationalizing supplementary material dosages, and refining steam curing regimes. These measures offer potential pathways to develop high-performance manufactured sand concrete with balanced mechanical and durability properties. Full article

This article aims to examine how the natural gas market evolved following the price shocks observed between 2020 and 2024, paying particular attention to market integration and the persistence of these shocks. The proposed analysis uses daily price data for the Title Transfer Facility (TTF), the main European benchmark traded on the Intercontinental Exchange and quoted in EUR/MWh, as well as Henry Hub (HH), the United States benchmark. These series are combined with a country panel on natural gas production, consumption, and gross domestic product for 59 economies, subject to data availability. The cointegration results show that TTF and HH prices moved together in 2019, but this relationship broke down in 2020 and did not return to its previous pattern in the following years. Granger causality tests point to a one-directional transmission from Henry Hub to Europe. Moreover, GARCH estimates indicate that TTF reacts almost twice as strongly to daily shocks as HH, while volatility remains persistent in both markets. Fixed-effects estimates place the TTF price elasticity of import spending close to 0.5, providing evidence consistent with a causal link between higher natural gas prices and higher domestic energy expenditure. Finally, the clustering analysis complements the econometric modeling by identifying four groups of countries defined by gas import dependency and gas intensity. This classification also offers implications for the global natural gas market since it points to the need for cluster-specific policy approaches rather than a single solution applied to every country. Full article

Background: Sustainable head and neck cancer (HNC) surgery is challenged by environmental impact, workforce shortages, inequitable access to advanced techniques, and policy constraints. Addressing these areas is critical for equitable, high-quality care. Methods: This structured narrative review synthesizes evidence on environmental sustainability, workforce development, technological innovation, health policy, and socioeconomic determinants in HNC surgery, without aiming to provide a systematic or exhaustive evidence synthesis. Sources included peer-reviewed literature, global workforce surveys, and international policy reports, with a focus on disparities between high-income countries (HICs) and low- and middle-income countries (LMICs). Results: Operating rooms produce up to 70% of hospital solid waste and consume 3–6 times more energy than other units; reusable instruments and improved waste segregation can reduce carbon footprints by over 50%. Workforce shortages are severe in LMICs, where subspecialty training is scarce; global partnerships, bidirectional education, and simulation-based learning can expand local capacity. Telemedicine, artificial intelligence, and three-dimensional printing enhance surgical planning, training, and access but may widen disparities without equitable deployment. Policy tools—including diagnosis-related groups, bundled payments, and universal coverage—affect access and innovation uptake. Pandemic preparedness underscores the value of resilient systems with flexible staffing and telehealth integration. Conclusions: HNC surgery requires coordinated action across environmental, workforce, technological, socioeconomic, and policy domains; however, future systematic reviews are needed to comprehensively map the evidence base and assess its methodological quality. Embedding sustainability in clinical practice, ensuring equitable innovation access, and aligning reimbursement with high-value care can strengthen system resilience, improve outcomes, and support long-term surgical service viability. Full article

With intensifying measures related to investor and policy requirements, corporate governance and sectoral environmental performance became a focal point for sustainability disclosure, especially in energy-intensive industries with high environmental externalities. This study evaluates whether corporate environmental governance practices in key sectors correspond to their pollution intensity and economic output, analysing a panel dataset across EU member states, for the 2000–2021 period. The empirical methodology includes ordinary least squares (OLS), fixed- and random-effects models, and dynamic system generalised method of moments (GMM) panel estimation to account for sectoral heterogeneity. Results prove that sectoral value added is an influential factor of greenhouse gas emissions, with carbon dioxide exhibiting the highest elasticity to economic activity, followed by methane emissions, and nitrous oxide displaying cross-country variations due to structural and regulatory differences. While services and manufacturing sectors partially decouple via cleaner technologies, overall growth positively correlates with emissions, and renewable energy offers limited mitigation due to scale and integration challenges. Conclusions emphasise robust governance frameworks in high-value energy sectors to meet EU climate-neutrality goals, as stronger environmental accountability attracts capital and supports sustainable development, underscoring the needs for targeted decarbonisation, regulatory coordination, and accelerated technological innovation within persistent industry disparities. Full article

Background: Long COVID (LC) has been associated with persistent endothelial dysfunction and vascular impairment. Although nutrition is a key modifiable determinant of cardiovascular health, the relationship between dietary macronutrient intake and vascular alterations in LC remains poorly understood. Objective: To evaluate the association between dietary macronutrient intake and markers of vascular structure, arterial stiffness, and vascular aging in patients with LC, including potential sex differences. Methods: We conducted a cross-sectional study including 304 patients with LC. Dietary intake was assessed using a validated 7-day dietary record (EVIDENT study). Vascular evaluation included carotid intima–media thickness (cIMT), carotid–femoral pulse wave velocity (cfPWV), brachial–ankle pulse wave velocity (baPWV), cardio-ankle vascular index (CAVI), augmentation index adjusted to a heart rate of 75 beats per minute (AIx@75), and vascular aging index (VAI), measured using carotid ultrasound and validated devices (SphygmoCor^® and VaSera^®). Results: The mean age was 53 ± 12, higher in men (p = 0.001). The study included 207 women (68%) and 97 men (32%). Energy intake and carbohydrate intake in g/day showed a negative association with cfPWV in Model 2 (energy intake: β = −0.06; 95% CI: −0.11 to −0.01; p = 0.02; carbohydrate intake: β = −0.47; 95% CI: −0.87 to −0.07; p = 0.02). The percentage of carbohydrate/total energy intake was positively associated with AIx@75 in Model 2 (β = 0.8; 95% CI 0.12 to 1.49; p = 0.02), and percentage of fat/total energy intake showed a consistent inverse association (β = −0.30; 95% CI: −0.49 to −0.11; p = 0.002). No significant associations were observed for cIMT, baPWV, CAVI or VAI. Conclusions: In patients with LC, total energy intake and absolute carbohydrate intake were negatively associated with cfPWV, whereas the relative contribution of carbohydrates and fats to total energy intake showed divergent associations with AIx@75. These findings suggest that both absolute macronutrient intake and relative macronutrient distribution may be related to central arterial stiffness and wave reflection parameters LC. However, given the cross-sectional design of the study, these results should be interpreted as exploratory and do not allow causal inference. Further longitudinal and interventional studies are needed to confirm these findings and to assess whether nutritional strategies may contribute to modulating vascular risk in this population. Full article

The growing share of intermittent renewable electricity has increased the need for long-duration storage in industrial energy systems. Meanwhile, many industrial processes still release recoverable low-grade waste heat. Introducing this heat into pumped thermal energy storage (PTES) can improve thermal integration, but industrial waste heat is often unsteady, and its temperature and mass flow fluctuations may disturb the charging process. This study investigates an air-based reverse Brayton PTES system assisted by an industrial hot-water waste heat stream of approximately 100 °C. A dynamic model was developed in Simulink/Simscape. The shaft speed is fixed at 3000 rpm, and a PID controller regulates the molten-salt flow rate to maintain the thermal storage temperature. The results show that increasing the waste heat temperature from 95 °C to 105 °C mainly changes the charging-side heat distribution. The waste heat utilization power increases from 36.0 MW to 37.9 MW, while the regenerator power decreases from 126.8 MW to 122.0 MW. The thermal storage power increases slightly from 117.0 MW to 119.0 MW, with the mechanical input fixed at 81.0 MW. The influence of waste heat temperature is concentrated near the low-temperature heat exchanger, regenerator, and turbine outlet. Under dynamic disturbances, faster temperature ramps increase short-term deviations, but the PID-based molten-salt flow regulation keeps the storage temperature close to 550 °C, indicating that the proposed control strategy can suppress moderate thermal disturbances during charging. When waste heat temperature and mass flow rate vary together, same-direction changes strengthen the disturbance, whereas opposite-direction changes partly offset it. These results clarify the disturbance propagation mechanism of fluctuating industrial waste heat in the PTES charging loop and provide a basis for the dynamic design and temperature-control strategy of waste-heat-assisted PTES systems. Full article

Automotive Noise, Vibration, and Harshness (NVH) has emerged as a critical interdisciplinary field influencing vehicle performance, passenger comfort, brand perception, and regulatory compliance. This thematic literature review synthesizes key research trends, methodological approaches, and technological developments shaping contemporary NVH studies. Drawing on 255 scholarly and industry sources, the review identifies five dominant themes: (1) sources and characterization of noise and vibration in internal combustion, hybrid, and electric vehicles; (2) advanced modeling and simulation techniques—including finite element analysis, statistical energy analysis, and machine learning–based prediction models; (3) materials, components, and structural optimization strategies for NVH mitigation; (4) the rapidly evolving landscape of electric and autonomous vehicle NVH; and (5) emerging active noise and vibration control technologies and data-driven diagnostics. The analysis highlights a definite shift toward holistic, data-driven, and multi-physics approaches, driven by lightweighting imperatives, widespread electrification, and increasingly stringent occupant comfort expectations. Key gaps in current research—including the need for unified evaluation metrics, real-time in-vehicle NVH monitoring, closer integration of subjective psychoacoustic perception with objective physical measurement, and validated simulation workflows for novel EV architectures—are identified and discussed. This review provides a consolidated and expanded framework for understanding contemporary NVH research directions and articulates opportunities for transformative innovation in next-generation vehicle development. Full article

Introduction: Aquatic chemical pollution is among the most worrying threats to ecosystem health. There is an ever-increasing variety of pollutant substances detected across the source-to-sea continuum, causing loss of biodiversity and ecological disequilibrium. Achieving cleaner and healthier systems relies on carrying out sustained, cost-effective, diagnosis and aquatic effects monitoring, within the adaptive management cycle. The available methods are, however, cumbersome, which creates a clear need for innovative expeditious approaches for low-cost surveillance monitoring. In the last decade, Raman Spectroscopy (RS) has gained wide recognition for application to biological questions, for its ability to uncover the complexity of molecules and their interactions. Various fields, from pharmacology to disease diagnosis and prognosis, have suffered an innovation revolution through the application of RS. In this technique inelastic light scattering of a small part of photons of an incident electromagnetic monochromatic light beam (ranging from near-infrared to visible or ultraviolet) is caused by the molecular vibration of chemical bonds. This results in shifts in energy, which indicate discrete vibrational modes of polarisable molecules, providing qualitative and quantitative assessments of the chemical composition and molecular structure of the sample. The technique shows high sensitivity, no need for sample preparation and the possibility of use in non-invasive and label-free analysis. Objective: The aim of this work is to present and discuss evidence about the application of Raman Spectroscopy (RS) to environmental diagnosis and aquatic effect monitoring of pollution. Methodology: The technique was applied to different biological models, i.e., diatoms, zebrafish embryos and larvae and freshwater snails. Quality assessments with diatoms were tested in environmental monitoring, while assessments with other models were done upon exposure to metals and organic contaminants. Results and conclusions: The Raman spectra obtained from the samples analysed comprised bands detected within the 800 to 2000 cm⁻¹ wavenumber range. These were related to bond vibrations of carbohydrates, DNA phosphate groups, proteins or CH, NH and OH stretching in lipids and proteins. Data analysis using chemometric methods clearly distinguished pollutant exposure from control sites or treatments, pointing out the potential for surveyance monitoring. The next steps include the comparison with other sensitive methods (e.g., locomotion and avoidance behaviours, omics methods) to assess efficiency and bring further mechanistic understanding. Full article

Agrivoltaic systems, which enable simultaneous crop production and solar photovoltaic (PV) electricity generation on the same land, can support climate mitigation, food security, and rural development. Leguminous crops like beans are globally important, yet there is limited performance studies on diverse agrivoltaic trials. This limits appropriate policy guidance. To overcome these limitations, this study assessed organic green bush bean performance under thirteen PV configurations with varying transparency and spectral properties, comparing both agricultural outcomes against national yields and policy standards. The results in vegetative metrics indicated that blue-spectrum thin-film and intermediate-transparency c-Si modules supported growth near German productivity thresholds. Although no agrivoltaic system matched national average yields, combining crop and energy revenues revealed substantial benefits: the 44%—transparent c-Si configuration generated 340% more total revenue than traditional farming, and the blue 70%—transparent thin-film system achieved 94% of national yield but 164% of conventional farm revenue per acre. Electricity generation gains outweighed modest crop reductions, highlighting strong synergies between food and energy. The results of this study highlights the potential of agrivoltaic systems to enhance land-use efficiency, support renewable energy expansion, and improve rural economic resilience, while underscoring the need for multi-year trials and site-specific controls to validate long-term sustainability outcomes. Full article

Sperm cryopreservation is important for livestock breeding and germplasm conservation, but freeze–thaw injury can impair ram sperm quality through oxidative stress, membrane damage, and metabolic disturbance. This study evaluated the concentration-dependent effects of kaempferol supplementation on the cryopreservation quality of semen from Yuansheng Aite dairy rams. Qualified ejaculates were pooled and randomly allocated to five equally spaced kaempferol treatment groups: 0, 25, 50, 75, and 100 μg/mL. Post-thaw sperm motility, oxidative stress status, ATP-related energy metabolism, acrosome integrity, and multi-omics profiles were evaluated. Data were analyzed using appropriate parametric or non-parametric tests after assessment of normality and homogeneity of variance. Orthogonal polynomial analysis was performed to evaluate linear and nonlinear dose–response patterns across the tested kaempferol concentrations. Kaempferol supplementation significantly affected PM, VCL, and VAP, while RPM, LIN, WOB, and VSL were not significantly affected. No significant linear effect was observed for the motility parameters, whereas VCL exhibited a significant quadratic response to kaempferol concentration. Based on the observed overall responses of sperm motility, antioxidant capacity, oxidative stress markers, ATP content, and acrosome integrity, 25 μg/mL kaempferol showed the most favorable overall profile among the tested concentrations and was selected for subsequent mechanistic analyses. Proteomic and metabolomic analyses suggested that the protective effects of kaempferol may be associated with pathways related to focal adhesion, cytoskeletal organization, oxidative phosphorylation-related energy metabolism, and central carbon metabolism. These findings indicate that moderate kaempferol supplementation may improve the post-thaw quality of Yuansheng Aite dairy ram semen, although further fertility-oriented studies are needed to confirm its practical reproductive benefits. Full article

The high energy consumption of conventional mixers equipped with active mixing elements necessitates the development of more efficient technologies for mixing bulk materials and feed mixtures. This study presents a gravity-driven mixing approach based on the rotation of an inclined cylindrical chamber, eliminating the need for active mixing elements. During chamber rotation, the mixture components move toward both end walls while simultaneously undergoing a circular motion along the inner cylindrical surface. This movement intensifies the mixing process and reduces energy consumption, thereby providing an energy-efficient gravity-based mixing approach that operates without active mixing elements. Laboratory experiments were conducted to determine the key physical and mechanical properties of the sapropel, organic fertilizer, and compound feed (formulation K-60-1). The measured values were as follows: velocity on an inclined steel surface, 0.65–1.21 m/s; coefficient of friction, 0.40–0.91; bulk density, 453–1166 kg/m³; and angle of repose, 36–39°. The experimental results confirmed the validity and adequacy of the developed analytical relationships. A structural and technological design of the gravity mixer was developed, and an experimental prototype was manufactured. Analytical relationships were obtained to determine the critical rotational speed of the chamber, particle movement velocity, and the power required for the mixing process. Under optimal operating conditions, the mixture uniformity reached 95.7% after 4 min of mixing. The mixer productivity was 0.95 t/h, while the specific energy consumption was 0.5 kWh/t, which is 2.5 times lower than that of conventional mixers equipped with active mixing elements. The obtained results confirm the feasibility and effectiveness of the proposed gravity-based mixing method for the preparation of feed and organomineral mixtures under the operating conditions of small-scale farms. Full article