Search Results (718)

Objectives: This study investigated whether CoQ10 supplementation enhances physical adaptations to high-intensity interval training (HIIT) in muscular strength, power, and physical function in older adults. Method: In a double-blind, randomized controlled trial, 38 adults aged 65–75 were assigned to either a CoQ10 (Females: 8; Males: 11) or placebo (Females: 8; Males: 11) group and completed an 8-week supervised HIIT program. Lower- and upper-body strength (30s 5-repetition chair stand [5XSST], chair standing [30CST], handgrip strength [HGR/L]), balance (single-leg stand [SLS], timed up and go [TUG]), mobility (25-foot walk [25FW]), and aerobic endurance (6-minute walk [6MWT]) were assessed pre- and post-intervention. Results: The CoQ10 group demonstrated significantly greater improvements in 5XSST and 30CST compared to the placebo group (p < 0.05). Both groups showed significant within-group improvements in right and left handgrip strength, SLS, 6MWT, and TUG (all p < 0.001), with no significant between-group differences observed for these outcomes (p > 0.05). No adverse events were reported. Conclusion: While CoQ10 supplementation enhanced improvements in lower-body strength and power, as indicated by the greater gains in 5XSST and 30CST performance compared to the placebo, no between-group differences were observed in TUG, grip strength, or other functional outcomes. This suggests that the performance-related effects of CoQ10 may be more specific to muscular power output and fatigue resistance, rather than general mobility or balance-related tasks. These findings highlight the potential of CoQ10 as a targeted adjunct in exercise for supporting lower-body function and physical performance in older adults. Full article

Background: Obesity during pregnancy increases the risk of adverse maternal and neonatal outcomes, and excessive gestational weight gain (GWG) remains highly prevalent worldwide. Although physical activity (PA) interventions have shown potential benefits, evidence on the optimal type, intensity, and duration of exercise for overweight or obese pregnant women remains limited. Methods: Electronic searches of EBSCOhost, Embase, PubMed and Web of Science were performed through August 2025 to identify randomized controlled trials comparing PA interventions versus usual prenatal care in overweight or obese pregnant women. Two reviewers independently screened studies, extracted data, and assessed risk of bias using Cochrane ROB domains. Continuous outcomes were pooled using inverse-variance meta-analytic methods and heterogeneity was quantified by I². Results: Ten randomized trials (twelve intervention arms) comprising 1150 participants met the inclusion criteria. In the domain of blinding of participants and personnel, three studies (30%) were judged as low risk, while seven (70%) were unclear. PA interventions varied in modality (aerobic, resistance, endurance, walking), setting (clinic, community, home/mHealth), and the intervention period ranges from 10 to 34 weeks. Most interventions (80%) employed moderate intensity, and 30% combined aerobic and resistance training. Results of the meta-analysis showed that the pooled mean GWG was 9.93 ± 5.48 kg in the treatment group and 10.65 ± 5.70 kg in the control group. Overall, PA interventions produced a modest but statistically significant reduction in GWG compared with controls, with negligible between-study heterogeneity (I² = 0%). Conclusions: Tailored, moderate-intensity PA may have the potential to modestly reduce GWG. Although 30% included trials employed combined aerobic and resistance training, current evidence is insufficient to establish whether combined modalities are more effective than aerobic-only or resistance-only interventions. However, the current evidence is limited by small trial sizes, methodological variability and geographic concentration in higher-income settings. Larger, rigorously designed RCTs, including evaluations of digital delivery platforms and carefully supervised higher-intensity protocols, are needed to refine exercise prescriptions and inform clinical guidelines. Full article

Background: Heart failure with reduced ejection fraction (HFrEF) markedly impairs quality of life (QoL) and life expectancy. The main therapeutic goals are to reduce mortality, improve functional capacity, and enhance QoL. Exercise training is an evidence-based, non-pharmacological component of standard care that improves functional capacity and clinical outcomes in HFrEF. This review examines the effects of endurance and resistance training on peak oxygen uptake (VO₂peak), ventilatory efficiency (VE/VCO₂ slope), health-related QoL, and cardiovascular outcomes in patients with HFrEF. Methods: A structured narrative review was conducted using comprehensive searches of PubMed, EMBASE, and the Cochrane Library for English-language studies published between January 2004 and October 2024. Eligible studies included adult HFrEF populations undergoing aerobic and/or resistance training with reported effects on VO₂peak, ventilatory efficiency, QoL, or clinical outcomes. Given the heterogeneity of interventions, comparators, and outcome metrics, data were synthesized descriptively. Results: Across 18 studies (plus one sub-analysis) including 3401 patients, 17 trials assessed VO₂peak and 16 reported significant improvements, with an average increase of approximately 2 mL·kg⁻¹·min⁻¹. Six studies assessed ventilatory efficiency, and five demonstrated reductions in VE/VCO₂ slope averaging 4.4 units. Eleven studies analyzed QoL, and nine reported significant improvements corresponding to an ≈5-point decrease in the Minnesota Living with Heart Failure Questionnaire (MLHFQ). In the largest trial, exercise training was associated with modest but statistically significant reductions in all-cause mortality or hospitalization (HR 0.89) and cardiovascular mortality or heart-failure hospitalization (HR 0.85) after adjustment for baseline prognostic factors. Conclusions: Structured exercise training improves aerobic capacity, ventilatory efficiency, and QoL in patients with HFrEF, with supportive evidence for reduced morbidity and mortality. These findings underscore the value of structured exercise as a core component of modern HFrEF management. Full article

Background: Findings show that beetroot-derived nitrates can improve endurance, oxygen efficiency, muscular power, recovery and cardiovascular function, particularly in recreationally active or moderately trained individuals. However, results are mixed in elite athletes, likely due to their already optimized nitric oxide utilization. Cognitive function is a crucial aspect of athletic performance enabling athletes to adapt to dynamic environments and execute skills effectively, but evidence for cognitive benefits of nitrate-rich beetroot supplementation is limited and inconsistent. The combination of improved physical activity and cognitive functions contribute to overall healthy aging and extending life expectancy. This highlights the synergistic role of nutrition, exercise and mental agility in promoting long-term well-being. Methods: The literature review was conducted to summarize and systematize existing evidence on beetroot juice supplementation on physical performance and cognitive function in both, healthy adult population and athletes. Results: Overall, beetroot supplementation demonstrates strong potential as a natural ergogenic aid for enhancing physical performance, but current evidence on cognitive improvement remains inconclusive. Conclusions: Further research, particularly involving female or elite athletes, is needed to establish clear recommendations of beetroot juice supplementation as a supportive element of exercise capacity and cognitive abilities contributing to maintaining health and thus healthy aging. Full article

The “athlete’s heart” phenotype, featuring resting bradycardia, has traditionally been viewed as a benign adaptation. However, emerging evidence associates prolonged, high-intensity endurance training with an increased risk of clinical sinoatrial node dysfunction. This systematic review synthesizes evidence on exercise-induced intrinsic Sinoatrial Node (SAN) electrophysiological remodelling and evaluates its dual nature along the adaptation–pathology continuum. Following PRISMA guidelines, a systematic search of PubMed, Web of Science, and Google Scholar (2000–2025) identified 17 eligible studies. Analysis revealed that in humans, rodents, and rabbits, exercise induces intrinsic SAN electrophysiological remodelling—a “membrane clock” reset characterized by coordinated downregulation of pacemaker currents, notably Hyperpolarization-activated cyclic nucleotide-gated cation channel (I_f), via the Nkx2.5-miR-423-5p transcription factor pathway. Evidence for “calcium clock” involvement remains inconsistent. In contrast, large animal models (e.g., dogs, horses) show only parasympathetic-mediated bradycardia without intrinsic remodelling. Training loads may induce structural changes (e.g., fibrosis), providing an anatomical substrate for pathology. Moderating factors such as training type and ageing contribute to a phenotype of “acquired SAN reserve reduction. Exercise-induced intrinsic SAN remodelling is a physiological adaptation mechanism that, under certain conditions, can cross a threshold to become a pathological cause of clinical dysfunction. Recognizing this continuum is essential for risk stratification and future therapeutic innovation. Full article

Glucagon-like peptide-1 receptor agonists and lifestyle interventions effectively treat overt obesity, but the benefits/risks of their combined early intervention during middle age remain unclear. This study investigated whether submaximal-dose liraglutide combined with strength–endurance training improves metabolic and liver health, focusing on hepatic oxidative stress and lipid metabolism. Male Wistar rats (16 months old) received liraglutide (L; 0.186 mg/kg/day, s.c.), training (ladder climbing with weights, 3 times/week), both (L+E) or saline for control middle-aged (C) and young adults (CY; 3–4 months old) for 7 weeks (n = 8/group). Middle-aged rats exhibited age-related changes including higher body and visceral fat, increased hepatic and serum cholesterol, hepatic ALT and glutathione imbalance, and decreased soleus muscle (p < 0.05, vs. CY). Exercise increased hepatic glycogen and oxidative stress markers and downregulated lipogenic genes, consistent with liver adaptation to training. L+E synergistically reduced body and visceral fat, hepatic and serum triglycerides, and the triglyceride–glucose index, while reducing oxidative stress (p < 0.05 vs. E, C) and lipogenic gene expression (p < 0.05 vs. C), without affecting pancreas histopathology and function parameters, muscle mass or exercise load volume. In conclusion, submaximal liraglutide safely synergized with training to enhance metabolic health, improve hepatic redox balance and triglyceride metabolism in middle-aged rats, without mitigating cholesterol rise. Full article

Background: Augmented reality (AR)-based exercise offers a low-cost option for home training, but the lack of supervision increases the risk of incorrect performance. Therefore, AR systems must demonstrate accuracy and effectiveness comparable to therapist-led training. To address this need, this study examined whether an AR-supported multi-component exercise program improves six key components of physical fitness. Methods: Twenty-eight healthy adults from South Korea were recruited and randomly assigned to either the AR group or the physical therapist (PT) group. Participants were assessed for six components of physical fitness: muscular strength, muscular endurance, balance, cardiorespiratory endurance, flexibility, and coordination. Each group performed the exercise program three times per week for four weeks, with each session lasting at least 30 min. Statistical analyses were conducted using paired t-tests to evaluate pre- and post-intervention effects within each group and independent t-tests to compare differences between the two groups. The level of statistical significance was set at p < 0.05. Results: Exploratory analyses showed that both groups demonstrated post-intervention improvements in muscular endurance, balance, flexibility, and coordination, while cardiorespiratory endurance and grip strength showed no notable changes. Between-group comparisons revealed significant differences only in right-hand relative grip strength at both baseline and post-intervention, with no other domains differing between groups. Conclusions: First, the AR-based intervention significantly improved muscular endurance, balance, flexibility, and coordination. Second, there were no significant differences between the AR-based and therapist-led interventions. Consequently, AR-based exercise programs may enhance specific components of physical fitness and could be effectively utilized to complement and extend therapist-led training sessions. Full article

Introduction: Nutrition plays a fundamental role in sports performance by influencing energy availability, recovery, and training adaptation. In recent years, different dietary strategies have gained popularity among athletes, although the evidence supporting their efficacy is inconsistent. Objective: This consensus document, developed under the auspices of the Spanish Society of Nutrition, aims to provide a critical overview of the most relevant nutritional strategies currently used in sports and to offer evidence-based practical recommendations for both professional and recreational athletes, coaches, and health professionals. Methods: A narrative review was conducted following standardized scientific procedures by a multidisciplinary panel of experts. The analyzed strategies included high-carbohydrate, low-carbohydrate, ketogenic, intermittent fasting, plant-based, Paleolithic, and carbohydrate periodization diets. Each strategy was assessed based on its physiological rationale, evidence of performance in endurance, strength/power, sprint, aesthetic, weight category, and team sports, practical applications, and potential risks. Results: The available evidence shows that no single dietary strategy can be universally recommended for all athletes. High carbohydrate availability remains the most consistent approach for sustaining performance in endurance and high-intensity efforts. Low-carbohydrate and ketogenic diets enhance fat oxidation but often compromise exercise economy at competitive intensity levels. Intermittent fasting may improve body composition and metabolic health; however, it requires careful adaptation. Well-planned plant-based diets can support performance, although attention to certain nutrients (e.g., B12, iron, and omega-3) is essential. Paleolithic diets improve metabolic parameters but show limited direct evidence of athletic performance. Carbohydrate periodization is a promising tool for combining metabolic adaptations with competitive demands. Conclusions: Nutritional strategies should be individualized according to the athlete’s sport, training phase, and personal context. Professional guidance is crucial for minimizing risks and optimizing benefits. Further well-designed, long-term studies on athletes are needed to resolve the current controversies. Full article

Background: Foam rolling has become an increasingly popular self-myofascial release (SMR) technique among athletes to prevent injuries, improve recovery, and increase athletic performance. This study investigated how SMR improves mechanical and movement efficiency in recreational road cyclists. Methods: We conducted an exploratory randomized controlled trial (RCT) to investigate the effects of SMR using a foam roller on biomechanical and physiological performance parameters over a six-month period. A total of 32 male participants, aged 26–57 years, with a mean Body Mass Index (BMI) of 24.0 kg/m² (SD = 2.2), were randomly assigned to either an intervention group (n = 16), which incorporated a standardized SMR program into their post-exercise recovery, or a control group (n = 16), which followed the same cycling protocol without SMR. The training program included heart rate-controlled strength endurance intervals. As the primary target, the variables we investigated included torque effectiveness, leg force symmetry, and pedal smoothness. Secondary measurements included submaximal oxygen uptake (VO₂) as well as bioelectrical variables, which we analyzed using classic, repeated-measures ANOVA models and descriptive statistical methods. Results: The analysis revealed significant interaction effects in favor of the intervention group for torque effectiveness (η²_p = 0.434), leg strength symmetry (η²_p = 0.303), and pedal smoothness (η²_p = 0.993). No significant group × time interactions were found for submaximal VO₂ or bioelectrical parameters. Conclusions: Our findings indicate that foam rolling may serve as an effective adjunct to endurance training by enhancing functional neuromuscular performance in cyclists, particularly in torque control and pedal coordination. Its impact on aerobic efficiency and muscle composition appears to be minimal. The results support theoretical models that attribute SMR benefits to proprioceptive, circulatory, and neuromuscular mechanisms rather than structural tissue adaptations. Full article

Jumping exercises are widely applied in sport performance and conditioning due to their crucial role in enhancing neuromuscular function and lower-limb power. Acute effects related to contractile properties measured by tensiomyography (TMG) remain insufficiently explored. This study aimed to examine the acute effects of two jump types—bilateral countermovement jumps (CMJs) and stiffness jumps (STs)—on the contractile properties of the vastus medialis (VM) and medial gastrocnemius (GM) muscles. Twenty-nine kinesiology students (fourteen males, fifteen females; age 19.4 ± 0.7 years) performed CMJ and ST protocols in a randomized order. Muscle contractile characteristics were measured before and immediately after each protocol and analyzed using a mixed-model repeated-measures ANOVA. Significant pre–post changes were found in both muscles. In the VM, contraction (Tc) and delay (Td) times decreased (p < 0.01), indicating faster responses, whereas relaxation time (Tr) increased and sustain time (Ts) decreased (p < 0.05), suggesting temporary fatigue. Maximal displacement (Dm) increased (p < 0.01), indicating reduced stiffness. In contrast, the GM showed greater responsiveness after stiffness jumps, characterized by shorter Tc and Td (p < 0.01), and reduced endurance after CMJs. These findings highlight muscle specific neuromuscular adaptations and provide practical insights for optimizing warm-up, training, and rehabilitation protocols through targeted jump selection. Full article

Muscle imbalance due to reduced muscular endurance is a significant risk factor. Thus, for the lower limb, muscle imbalance is one of the most common causes of traumatic injury. A number of studies on isoinertial technology have demonstrated that it allows the development of forces similar to or greater than those generated in the same exercise but performed with traditional weights. Our research aimed to analyze the morpho-functional changes at the muscle level using ultrasound, and the evolution of muscle power output express of maximal muscle strength at the level of the knee extensors, specifically the rectus femoris muscle, following an isoinertial training program. The study included 11 female soccer-practicing sportswomen with average age (15.18 ± 1.08). The assessment included an ultrasound assessment of the rectus femoris muscle, before and after isoiniertial training (post acute moment); a muscle force assessment using dynamometry; and an evaluation of isoinertial parameters as concentric and excentric power, in terms of coefficients that represent report between the left and right sides. The isoinertial protocols training included three weekly sessions of isoinertial exercises. The results show an increase in the values of the ultrasound dimensions, approximately at the same level for both measured dimensions, which is significant for demonstrating the existence of an increase in muscle volume. An important progress is observed in the mean maximum strength and maximum force, but especially in the duration of maintenance of the maximum loading force. There is no statistically significant symmetry at the level of the rectus femoris muscle for concentric power and no statistically significant symmetry tendency for eccentric power, although there is a favorable evolution in terms of values. Full article

Pull-ups are a widely recognized exercise for training and assessing upper-body strength and muscular endurance, requiring coordinated activation of the latissimus dorsi, biceps brachii, forearm flexors, and core stabilizers. However, many individuals experience difficulty performing pull-ups due to inadequate grip strength or core stability. This study aimed to investigate the comparative effects of forearm-specific and core-specific training, combined with standardized pull-up routines, on upper-body performance indicators in physically inactive male students. Thirty participants (age = 21 ± 1.58 years) were randomly assigned to three groups (n = 10): pull-up plus interval training (PIT), pull-up plus forearm training (PFT), and pull-up plus core training (PCT). All groups performed identical pull-up-based programs for eight weeks, differing only in the supplemental exercises. Before and after the intervention, participants were tested for maximum pull-up repetitions, grip strength (both hands), and dead-hanging time. Significant improvements were found in all variables (p ≤ 0.009), with group differences in pull-up repetitions (p < 0.001) and right-hand grip strength (p = 0.004). The PFT group achieved the greatest gains, with a 222.5% increase in repetitions, 12% and 14.0% increases in right- and left-hand grip strength, and a 55.3% increase in hanging time. The PCT group showed moderate progress, while PIT yielded the smallest improvement. Forearm-specific training proved the most effective strategy for enhancing pull-up performance, grip strength, and endurance. Full article

Caffeine, a nervous system stimulant, and sodium bicarbonate, a metabolic buffer, have been shown to improve performance in high-intensity, particularly aerobic, exercises. This randomized, double-blind, placebo-controlled, crossover study compared the acute effects of caffeine and sodium bicarbonate on chest press (CP) and knee extension (KE) performance. Twelve resistance-trained young adults (seven females) completed three testing sessions during which they consumed caffeine (0.003 g/kg of body weight), sodium bicarbonate (0.3 g/kg of body weight), or placebo at 120, 90, and 60 min prior to testing. Testing consisted of six sets of CP and KE for as many repetitions as possible at 70% of the participants’ 1-repetition maximum load. A 60 s recovery between sets, and 2 min recovery was allocated between exercises. Blood pressure and blood lactate were recorded pre-, mid-, and post-test. Heart rate, ratings of perceived exertion (RPE), repetitions, and electromyography (EMG) were recorded for every set. No significant differences were found under any condition for RPE, EMG, and KE repetitions. A main effect for groups revealed was increased CP repetitions with sodium bicarbonate (7.42; 95%CI: 6.8–7.9) versus caffeine (6.7; 95%CI: 6.1–7.3) and control (7.1; 95%CI: 6.4–7.6) conditions. However, post hoc analysis did not achieve significance. Diastolic blood pressure was significantly (p = 0.03) greater with caffeine (79.2 mmHg; 95%CI: 74.6–83.7) than with sodium bicarbonate (72.7 mmHg; 95%CI: 67.5–77.9) and control (74.5 mmHg; 95%CI: 71.7–77.3). Females had significantly lower blood lactate measurements, higher CP repetitions, and lower heart rates, despite similar resting heart rates between the sexes. Caffeine (0.003 g/kg) or sodium bicarbonate (0.3 g/kg) did not provide acute ergogenic effects on CP or KE strength endurance (six sets of CP and KE at 70% 1-repetition maximum load) performance in young adult women and men. Full article

Introduction: Red spinach powder (RSP) contains high amounts of inorganic nitrate/nitrite (NO₃/NO₂), which has been suggested to alter vascular activity, cognitive processing, and sprint exercise performance. There have been few investigations as to whether RSP serves as an ergogenic aid to improve resistance exercise performance, particularly muscular endurance. Purpose: The purpose of this study was to investigate acute RSP (VitaSpinach^®) supplementation on muscular endurance and velocity during bench press exercise. Methods: In a double-blind, counterbalanced crossover manner, resistance-trained males (n = 14) were subjected to two supplement conditions as follows: (1) placebo (PL; purple sweet potato) or (2) red spinach powder (RSP; 400 mg NO₃). Supplements were consumed 2 h prior to exercise and blood was collected immediately pre-exercise to determine NO₃/NO₂ levels. To determine barbell velocity, participants completed two sets × two repetitions with maximal effort, while a rotary encoder measured mean barbell velocity. Following this, participants performed three sets × repetitions to exhaustion (RTE) at 60% of 1-Repetition Maximum (1-RM), separated by 2 min of rest, to determine muscular endurance. Local (lRPE) and global (gRPE) ratings of perceived exertion were measured after exercise. Blood NO₃/NO₂, RTE, mean velocity, lRPE, and gRPE were compared between supplement conditions. Results: RSP resulted in significantly higher blood levels of total NO₃/NO₂ (p < 0.001) compared to PL. RSP did not result in superior total RTE (p = 0.935) but increased mean velocity (p = 0.035) compared to PL. Both lRPE (p = 0.027) and gRPE (p = 0.028) were significantly reduced with RSP supplementation. Conclusions: Findings suggest acute RSP ingestion increased NO₃/NO₂ and bench press velocity. While muscular endurance remained unchanged, RSP resulted in lower perceptions of exertion. Full article

Background/Objectives: Despite increasing awareness of best sports nutrition practices, discrepancies persist between knowledge and behaviour amongst female endurance athletes. Methods: To understand this discrepancy study investigated dietary practices, macronutrient intakes, and influ-encing factors using a multi-method approach. Seventy-two female endurance athletes (42 ± 9 y) completed four-day weighed food diaries, and a subset of twenty athletes (40 ± 10 y) then participated in semi-structured interviews. Quantitative analysis revealed that athletes met the lower end of carbohydrate (CHO) guidelines on rest days (3.0 g·kg⁻¹), but intake fell short on training days, with deficits increasing as training volume rose (moderate: −1.4 g·kg⁻¹, high: −3.5 g·kg⁻¹, very high: −5.5 g·kg⁻¹). Despite awareness of CHO’s role in performance, athletes unintentionally underfuelled, leading to a cumu-lative energy deficit. Energy intake increased by 473 kcal·day⁻¹ per 1000 kcal·day⁻¹ of exercise energy expenditure. In contrast, protein intake was prioritised, with mean in-takes of 1.7 ± 0.7 g·kg⁻¹·day⁻¹ aligning with recommendations. Results: Qualitative findings iden-tified barriers to CHO intake, including time constraints, diet culture influences and body image concerns. Social and environmental factors, such as household environments and professional nutrition guidance, played a critical role in behaviours. Conclusions: These findings highlight the need for practical, evidence-based nutrition interventions to support fe-male endurance athletes. Personalised education addressing CHO requirements, the psychology/emotions around nutrition, and the influence of social environments may bridge the gap between knowledge and practice, optimising both performance and long-term health outcomes. Full article