Search Results (191)

Emotion analysis based on electroencephalogram (EEG) sensors is pivotal for human–machine interaction yet faces key challenges in spatio-temporal feature fusion and cross-band and brain-region integration from multi-channel sensor-derived signals. This paper proposes MB-MSTFNet, a novel framework for EEG emotion recognition. The model constructs a 3D tensor to encode band–space–time correlations of sensor data, explicitly modeling frequency-domain dynamics and spatial distributions of EEG sensors across brain regions. A multi-scale CNN-Inception module extracts hierarchical spatial features via diverse convolutional kernels and pooling operations, capturing localized sensor activations and global brain network interactions. Bi-directional GRUs (BiGRUs) model temporal dependencies in sensor time-series, adept at capturing long-range dynamic patterns. Multi-head self-attention highlights critical time windows and brain regions by assigning adaptive weights to relevant sensor channels, suppressing noise from non-contributory electrodes. Experiments on the DEAP dataset, containing multi-channel EEG sensor recordings, show that MB-MSTFNet achieves 96.80 ± 0.92% valence accuracy, 98.02 ± 0.76% arousal accuracy for binary classification tasks, and 92.85 ± 1.45% accuracy for four-class classification. Ablation studies validate that feature fusion, bidirectional temporal modeling, and multi-scale mechanisms significantly enhance performance by improving feature complementarity. This sensor-driven framework advances affective computing by integrating spatio-temporal dynamics and multi-band interactions of EEG sensor signals, enabling efficient real-time emotion recognition. Full article

Cancer-related cognitive impairment (CRCI)—encompassing anxiety, depression, and memory deficits—significantly diminishes the quality of life in patients with cancer, yet remains underrecognized in clinical practice. In this study, we investigated the therapeutic potential of tabernanthalog (TBG), a non-hallucinogenic analog of psychedelic compounds, as a novel intervention for CRCI using a Lewis lung carcinoma (3LL) mouse model. Behavioral assessments revealed heightened anxiety-like behavior and memory impairment following 3LL cell transplantation. Biochemical analysis revealed reduced tryptophan levels in both blood and hippocampal tissue, accompanied by the downregulation of serotonergic receptor genes and upregulation of pro-inflammatory cytokine genes in the hippocampus of tumor-bearing mice. Additionally, microglial density and morphological activation were markedly elevated. TBG treatment reversed these behavioral deficits, improving both anxiety-related behavior and memory performance. These effects were associated with the normalization of microglial density and morphology, as well as the restoration of serotonergic receptor and cytokine gene expression. In vitro, TBG partially suppressed neuroinflammatory gene expression in BV-2 microglial cells exposed to conditioned medium from 3LL cells. Collectively, these findings suggest that TBG alleviates CRCI-like symptoms by modulating neuroinflammation and microglial activation. This study highlights TBG as a promising therapeutic candidate for improving cognitive and emotional functioning in patients with cancer. Full article

Post-traumatic stress disorder (PTSD) is a chronic mental health condition resulting from exposure to traumatic events. It is associated with long-term neurobiological changes and disturbances in emotional regulation. Understanding the sociodemographic profiles, biomarkers, and emotional control in patients with PTSD helps to better comprehend the impact of the disorder on the body and its clinical course. An analysis of biomarkers such as Interleukin-18 (IL-18), Inositol-Requiring Enzyme 1 (IRE1), Phosphorylated Extracellular Signal-Regulated Kinase (pERK), and Activating Transcription Factor–6 (ATF-6) in PTSD patients with varying durations of illness (≤5 years and >5 years) and a control group without PTSD revealed significant differences. Patients with recently diagnosed PTSD (≤5 years) showed markedly elevated levels of inflammatory and cellular stress markers, indicating an intense neuroinflammatory response during the acute phase of the disorder. In the chronic PTSD group (>5 years), the levels of these biomarkers were lower than in the recently diagnosed group, but still significantly higher than in the control group. An opposite trend was observed regarding the suppression of negative emotions, as measured by the Courtauld Emotional Control Scale (CECS): individuals with chronic PTSD exhibited a significantly greater suppression of anger, depression, and anxiety than those with recent PTSD or healthy controls. Correlations between biomarkers were strongest in individuals with chronic PTSD, suggesting a persistent neuroinflammatory dysfunction. However, the relationships between biomarkers and emotional suppression varied depending on the stage of PTSD. These findings highlight the critical role of PTSD duration in shaping the neurobiological and emotional mechanisms of the disorder, which may have important implications for therapeutic strategies and patient monitoring. Full article

Hormonal contraceptives (HCs) are widely used and generally well tolerated; however, their neuroendocrinological effects remain underappreciated in clinical decision-making. Beyond ovulation suppression, HCs influence brain function by modulating key neurotransmitters such as GABA, serotonin, and dopamine, as well as neurosteroids like allopregnanolone and β-endorphin. These interactions help explain why some users experience mood swings, anxiety, or changes in sexual desire, while others report improvements in well-being. In this narrative review, we explore how different estrogenic and progestin components affect central pathways involved in emotional regulation and cognition. Evidence suggests that estradiol or estetrol-based formulations combined with anti-androgenic progestins like drospirenone or nomegestrol acetate may offer a more favourable neuroendocrine profile, particularly in women with a history of mood disorders or hormonal sensitivity. Understanding these neuroendocrine mechanisms may support more personalized contraceptive choices, particularly in women with mood disorders and hormonal vulnerability. Full article

Neuroinflammation is a key feature of Alzheimer’s disease (AD), and stem cell therapies have emerged as promising candidates due to their immunomodulatory properties. Neuro-Cells (NC), a combination of unmodified mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs), have demonstrated therapeutic potential in models of central nervous system (CNS) injury and neurodegeneration. Here, we studied the effects of NC in APPswe/PS1dE9 mice, an AD mouse model. Twelve-month-old APPswe/PS1dE9 mice or their wild-type littermates were injected with NC or vehicle into the cisterna magna. Five to six weeks post-injection, cognitive, locomotor, and emotional behaviors were assessed. The brain was stained for amyloid plaque density using Congo red, and for astrogliosis using DAPI and GFAP staining. Gene expression of immune activation markers (Il-1β, Il-6, Cd45, Tnf) and plasticity markers (Tubβ3, Bace1, Trem2, Stat3) was examined in the prefrontal cortex. IL-6 secretion was measured in cultured human monocytes following endotoxin challenge and NC treatment. Untreated APPswe/PS1dE9 mice displayed impaired learning in the conditioned taste aversion test, reduced object exploration, and anxiety-like behavior, which were improved in the NC-treated mutants. NC treatment normalized the expression of several immune and plasticity markers and reduced the density of GFAP-positive cells in the hippocampus and thalamus. NC treatment decreased amyloid plaque density in the hippocampus and thalamus, targeting plaques of <100 μm². Additionally, NC treatment suppressed IL-6 secretion by human monocytes. Thus, NC treatment alleviated behavioral deficits and reduced amyloid plaque formation in APPswe/PS1dE9 mice, likely via anti-inflammatory mechanisms. The reduction in IL-6 production in human monocytes further supports the potential of NC therapy for the treatment of AD. Full article

The human circadian rhythm is connected to the body’s endogenous clock and can influence people’s natural sleeping habits as well as a variety of other biological functions. According to research, various electric light sources in interior locations can disrupt the human circadian rhythm. Many psychological studies, on the other hand, reveal that different colors can have varied connections with and a variety of effects on people’s emotions. In this study, the effects of light source attributes and interior space paint color on human circadian rhythm were studied using 24 distinct computer simulations. Simulations were performed using the ALFA plugin for Rhinoceros 6 on an unfurnished bedroom 3D model at night. Results suggest that cooler hues, such as blue, appear to have an unfavorable effect on human circadian rhythm at night, especially when utilized in spaces that are used in the evening, which contradicts what psychologists and interior designers advocate in terms of the soothing mood and nature of the color. Furthermore, the effects of Correlated Color Temperature (CCT) and the intensity of a light source might be significant in minimizing melanopic lux to prevent melatonin suppression at night. These insights are significant for interior designers, architects, and lighting professionals aiming to create healthier living environments by carefully selecting lighting and color schemes that support circadian health. Incorporating these considerations into design practices can help mitigate adverse effects on sleep and overall well-being, ultimately contributing to improved occupant comfort and health. Full article

Background/Objectives: Colorectal cancer (CRC) patients undergoing chemotherapy often experience anemia, oxidative stress, and immune suppression, significantly impacting their quality of life and treatment outcomes. Normobaric oxygen (NBO) therapy, which delivers oxygen at atmospheric pressure with an elevated oxygen concentration, has shown the potential to enhance erythropoiesis, reduce oxidative stress, and modulate immune function. However, its efficacy in CRC patients remains underexplored. This study aims to evaluate the effects of NBO exposures on (1) supporting erythropoiesis by measuring erythropoietin (EPO) levels and hypoxia-inducible factor 1-alpha (HIF-1α), (2) reducing oxidative stress and improving stress and emotional well-being, and (3) modulating immune function by assessing cytokine profiles. Secondary objectives include assessing the impact of NBO on patient-reported outcome measures (PROMs) such as stress, anxiety, depression, and quality of life. Methods: This is a prospective, randomized, double-blind, placebo-controlled clinical trial. A total of 254 CRC patients undergoing chemotherapy will be randomized 1:1 to receive either active NBO therapy (n = 127, study group) or placebo NBO therapy (n = 127, control group). The intervention will consist of 10 NBO sessions over five weeks. Primary outcomes include biomarkers of erythropoiesis, oxidative stress, and immune response. Secondary outcomes assess quality of life and psychological well-being. Data will be collected at baseline, mid-intervention, post-intervention, and during two follow-up visits (3 and 6 months post-intervention). Results: The study hypothesizes that NBO therapy will improve erythropoiesis, reduce oxidative stress, and enhance immune function in CRC patients, leading to improved quality of life and clinical outcomes. Conclusions: Findings from this trial may establish NBO as a novel supportive therapy for CRC patients undergoing chemotherapy. Full article

In addition to recruiting new staff, retaining qualified teachers and supporting their mental well-being are becoming key priorities in German schools. One crucial factor associated with well-being is the use of emotion management. Given the emotional demands of the teaching profession, this study examines teachers’ strategies to manage their work-related emotions and the role of school-based support in maintaining mental health. The analysis is based on interviews with 51 primary and secondary school teachers in Germany, using thematic analysis following Braun and Clarke. The results indicated that teachers employed various strategies to manage their emotions. In classroom settings, suppression—a response-focused strategy—was frequently used. Outside the classroom, teachers tended to seek emotional relief through attentional shifts and conversations with colleagues or family, which offer reassurance, cognitive reframing, and emotional release. The findings underscore the importance of a supportive school culture characterized by collegial exchange, supervision, counseling, and committed leadership. Such environments can reduce emotional strain and contribute significantly to teachers’ well-being. Implementing opportunities for consultation and collegial case discussion during working hours may represent a valuable investment in teacher retention, particularly in times of teacher shortages. Full article

In informal economic contexts, migrant entrepreneurs have been extolled as highly resilient and adaptable. This study critically investigates the adverse psychological foundations inherent in such enterprises, focusing on how dark triad personality traits emerge in the leadership orientations of marginal migrant entrepreneurs. Following a qualitative ethnographic approach, this research engaged 10–15 migrant employees through participant observation, field notes, and semi-structured interviews in an informal economic context. Thematic analysis revealed five dominant patterns: narcissistic leadership with entitlement and emotional disrespect; Machiavellian behavior of manipulation and deception; psychopathic detachment in emotional callousness; absence of light triad actions such as empathy, humility, and selflessness; and moral disengagement through rationalizations such as “everyone does it” or system blame. Migrant business owners prefer to rationalize their exploitative acts as being necessary for economic survival, thus legitimizing immoral conduct and suppressing moral self-regulation. The findings indicate that marginality not only drives entrepreneurial innovation, but also has the potential to create exploitative inclinations that are institutionally and morally unchecked. Solving this issue requires not only mere psychological awareness, but also systematic reforms that foster ethical robustness and emotional sensitivity. This study ultimately asserts the need to reframe migrant entrepreneurship discourse, including both ethical and psychological accountability. Full article

Contemporary educational literature suggests that academic emotions and emotion regulation should be explored in tandem, while academic motivation has been discussed both as a self-regulation metacognitive construct and as a construct inherently tied to motivation. The present study uses a person-centered approach to explore profiles of university students based on academic emotions, emotion regulation, academic self-regulation, and approaches to learning. In addition, the impact of students’ profiles on academic performance (GPA) is investigated. The sample consists of 509 university students studying at a Greek university social science department. Cluster techniques and multivariate analysis of variance are used to identify the profiles and test for differences among them. Students were grouped in clusters that revealed both consistent and dissonant patterns of scores on the relevant variables. Analysis reveals three distinct profiles: (a) the “Anxious, effectively-engaged, and organized learners”, (b) the “Deep, Happy, and intrinsically motivated learners” and (c) the “Disengaged, Bored, and Suppressing Learners”. These profiles open new insights into educational literature, revealing links among learning, emotional, and motivational factors. Practical implications and directions for future research are discussed. Full article

Background/Objectives: Burnout and anger are prevalent among healthcare professionals in high-stress environments, particularly in addiction services. This study explores the relationship between burnout and anger among 124 operators working in public addiction services (SERD) in Calabria and Sicily. The objective is to assess how different anger dimensions contribute to burnout and identify protective factors that could inform targeted interventions. Methods: The sample consisted of 58 men and 66 women, with a mean age of 39.2 years (SD = 9.8), ranging from 25 to 59 years old. Burnout was measured using the Maslach Burnout Inventory (MBI), assessing emotional exhaustion, depersonalization, and personal accomplishment. Anger was evaluated through the State-Trait Anger Expression Inventory-2 (STAXI-2), examining trait anger, state anger, anger expression (anger-in, anger-out), and anger control. A cross-sectional design was used, with correlation and regression analyses controlling for gender and years of service. Results: High levels of burnout, particularly emotional exhaustion and depersonalization, were found. Emotional exhaustion correlated strongly with trait anger, indicating that individuals with a chronic predisposition to anger are more vulnerable to burnout. Suppression of anger (anger-in) significantly predicted depersonalization, exacerbating emotional disengagement from patients. Conversely, anger control acted as a protective factor, helping maintain a sense of personal accomplishment. Conclusions: These findings underscore the importance of emotional regulation in mitigating burnout among addiction service workers. Interventions such as emotional regulation training and anger management programs could help reduce psychological distress and promote resilience. Workplace strategies that support emotional well-being may improve both staff retention and patient care quality. Further research should explore longitudinal trends and intervention effectiveness. Full article

Empathy has been linked to enhanced processing of social information, yet the neurophysiological correlates of such individual differences remain underexplored. Objectives: The aim of this study was to investigate how individual differences in trait empathy are reflected in oscillatory brain activity during the perception of non-verbal social cues. Methods: In this EEG study involving 30 participants, we examined spectral and time–frequency dynamics associated with trait empathy during a visual task requiring the interpretation of others’ body gestures. Results: FFT Power spectral analyses (applied to alpha/mu, beta, high beta, and gamma bands) revealed that individuals with high empathy quotients (High-EQ) exhibited a tendency for increased beta-band activity over frontal regions and markedly decreased alpha-band activity over occipito-parietal areas compared to their low-empathy counterparts (Low-EQ), suggesting heightened attentional engagement and reduced cortical inhibition during social information processing. Similarly, time–frequency analysis using Morlet wavelets showed higher alpha power in Low-EQ than High-EQ people over occipital sites, with no group differences in mu suppression or desynchronization (ERD) over central sites, challenging prior claims linking mu ERD to mirror neuron activity in empathic processing. These findings align with recent literature associating frontal beta oscillations with top-down attentional control and emotional regulation, and posterior alpha with vigilance and sensory disengagement. Conclusions: Our results indicate that empathic traits are differentially reflected in anterior and posterior oscillatory dynamics, supporting the notion that individuals high in empathy deploy greater cognitive and attentional resources when decoding non-verbal social cues. These neural patterns may underlie their superior ability to interpret body language and mental states from visual input. Full article

With the advancement of global economic restructuring and China’s economic transformation, structural employment contradictions have intensified amid increasingly competitive labor markets. The frequent occurrences of “degree devaluation” and talent “downskilling” have made perceived overqualification increasingly prevalent in organizations. This study, based on the Cognitive–Affective Personality System theory, investigates the differential mechanisms through which perceived overqualification drives approach and avoidance job crafting via cognitive and affective pathways. Data from a two-wave survey of 556 Chinese employees produced several key findings: (1) Perceived overqualification significantly enhances approach job crafting while suppressing avoidance job crafting by elevating role breadth self-efficacy (cognitive pathway), demonstrating a proactive breakthrough effect. (2) Perceived overqualification inhibits approach job crafting and exacerbates avoidance job crafting through triggering emotional exhaustion (affective pathway), revealing a passive exhaustion trap. (3) Perceived overqualification exerts a positive and significant overall indirect effect on approach job crafting through the combined mechanisms of cognitive gains from role breadth self-efficacy and affective costs from emotional exhaustion, whereas the overall indirect effect on avoidance job crafting is non-significant. (4) Idiosyncratic deals (i-deals) function as a dynamic boundary mechanism that amplifies the positive impact of role breadth self-efficacy and mitigates the negative effects of emotional exhaustion, while moderating the mediating roles of both pathways. This research develops a dual-path integrated model of perceived overqualification and job crafting by classifying job crafting categories, incorporating cognitive–affective pathways, and introducing i-deals as a contextual element. These findings respond to scholarly demands for elucidating the intricate connections between perceived overqualification and job crafting through integrative perspectives; in addition, they offer theoretical and practical insights for organizations to leverage the potential of overqualified individuals appropriately. Full article

Emotion regulation (ER) strategies, such as reappraisal and suppression, have been linked to psychological well-being. The available evidence points to the differential impact of ER strategies on resilience and post-traumatic growth (PTG), as factors related to well-being, as well as to sex differences in the link between ER preference and well-being. However, previous studies are mixed regarding these links. To address this issue, college students (N = 1254) recruited between 2020 and 2023 reported their habitual use of ER strategies, resilience and PTG during the COVID-19 pandemic, which, as a global health crisis, has raised not only severe physical health concerns but also mental distress. First, reappraisal was positively associated with both resilience and PTG, whereas suppression was negatively correlated with these measures. Second, female participants had lower suppression scores and higher PTG scores than male participants. Third, a moderation analysis showed that the positive relationship between reappraisal and PTG was stronger in female participants, whereas the negative relationship between suppression and PTG was stronger in male participants. Overall, these findings shed light on the links among ER strategies, resilience, and PTG and have relevance for customized training in the use of reappraisal to increase well-being in women and men. Full article

This study aimed to explore the relationships among peer and teacher support, emotional intelligence, and creative thinking. A total of 335 middle school students in grade seven were surveyed in China, including boys 187 (55.8%) and girls 148 (44.2%), aged from 11 to 14 years (M = 12.5; SD = 0.5). Results of the partial least square structural equation modeling showed that emotional intelligence was a positive mediator in the processes from peer and teacher support to middle school students’ creative thinking, and emotion regulation strategies moderated these processes from emotional intelligence to creative thinking. Specifically, both peer and teacher support had an indirect effect on creative thinking through emotional intelligence. Moreover, the four dimensions of emotional intelligence bore different mediating powers. Among them, emotion regulation exhibited the greatest mediating power, and self-emotion appraisal is the least. In addition, both reappraisal and suppression positively moderated the impact of emotional intelligence on creative thinking. Moreover, reappraisal had stronger moderating power than that of suppression. Interestingly, the direct effects of both peer and teacher support on creative thinking were not observed. This study offers knowledge about the mechanisms of peer and teacher support and students’ creative thinking, and implications for practitioners were also discussed in this study. Full article