Search Results (12)

Love as a complex interplay of emotions and behaviors is underpinned by an intricate network of neurobiological mechanisms. This review provides insight into the molecular basis of love, focusing on the role of key hormones and neuromodulators. The aim of the paper is to report how these biochemical messengers influence various aspects of love, including attraction, attachment, and long-term bonding. By examining the effects of hormones such as dopamine, oxytocin, vasopressin, and serotonin, we aim to elucidate the intricate relationship between biology and behavior. Additionally, the potential impact of modern lifestyle factors on hormonal balance and their subsequent influence on love and social interactions are outlined. This review provides a useful overview of the molecular underpinnings of love, offering insights into the biological mechanisms that shape human relationships. Full article

Fragile X Syndrome (FXS) presents with a constellation of phenotypes, including trouble regulating emotion and aggressive behaviors, disordered sleep, intellectual impairments, and atypical physical development. Genetic study of the X chromosome revealed that substantial repeat expansion of the 5′ end of the gene fragile X messenger ribonucleoprotein 1 (FMR1) promoted DNA methylation and, consequently, silenced expression of FMR1. Further analysis proved that shorter repeat expansions in FMR1 also manifested in disease at later stages in life. Treatment and therapy options do exist, but they only manage symptoms. Up to now, no cure for FMR1 disorders exists. In this review, we aim to provide an overview of FMR1 biology and the latest research focused on developing therapeutic interventions that can potentially prevent and/or reverse FXS. Full article

Fear is characterized by distinct behavioral and physiological responses that are essential for the survival of the human species. Fear conditioning (FC) serves as a valuable model for studying the acquisition, extinction, and expression of fear. The serotonin (5-hydroxytryptamine, 5-HT) system is known to play a significant role in emotional and motivational aspects of human behavior, including fear learning and expression. Accumulating evidence from both animal and human studies suggests that brain regions involved in FC, such as the amygdala, hippocampus, and prefrontal cortex, possess a high density of 5-HT receptors, implicating the crucial involvement of serotonin in aversive learning. Additionally, studies exploring serotonin gene polymorphisms have indicated their potential influence on FC. Therefore, the objective of this work was to review the existing evidence linking 5-HT with fear learning and memory in humans. Through a comprehensive screening of the PubMed and Web of Science databases, 29 relevant studies were included in the final review. These studies investigated the relationship between serotonin and fear learning using drug manipulations or by studying 5-HT-related gene polymorphisms. The results suggest that elevated levels of 5-HT enhance aversive learning, indicating that the modulation of serotonin 5-HT2A receptors regulates the expression of fear responses in humans. Understanding the role of this neurochemical messenger in associative aversive learning can provide insights into psychiatric disorders such as anxiety and post-traumatic stress disorder (PTSD), among others. Full article

This article presents a project which is an experiment in the emerging field of human-machine artistic collaboration. The author/artist investigates responses by the generative pre-trained transformer (GPT-2) to poetic and esoteric prompts and curates them with elements of digital art created by the text-to-image transformer DALL-E 2 using those same prompts; these elements are presented in the context of photographs featuring an anthropomorphic female avatar as the messenger of the content. The tripartite ‘cyborg’ thus assembled is an artificial intelligence endowed with the human attributes of language, art and visage; it is referred to throughout as Madeleine. The results of the experiments allowed the investigation of the following hypotheses. Firstly, evidence for a convergence of machine and human creativity and intelligence is provided by moderate degrees of lossy compression, error, ignorance and the lateral formulation of analogies more typical of GPT-2 than GPT-3. Secondly, the work provides new illustrations supporting research in the field of artificial intelligence that queries the definitions and boundaries of accepted categories such as cognition, intelligence, understanding and—at the limit—consciousness, suggesting that there is a paradigm shift away from questions such as “Can machines think?” to those of immediate social and political relevance such as “How can you tell a machine from a human being?” and “Can we trust machines?” Finally, appearance and epistemic emotions: surprise, curiosity and confusion are influential in the human acceptance of machines as intelligent and trustworthy entities. The project problematises the contemporary proliferation of feminised avatars in the context of feminist critical literature and suggests that the anthropomorphic avatar might echo the social and historical position of the Delphic oracle: the Pythia, rather than a disembodied search engine such as Alexa. Full article

Dissociative disorders are a common and frequently undiagnosed group of psychiatric disorders, characterized by disruptions in the normal integration of awareness, personality, emotion and behavior. The available evidence suggests that these disorders arise from an interaction between genetic vulnerability and stress, particularly traumatic stress, but the attention paid to the underlying genetic diatheses has been sparse. In this paper, the existing literature on the molecular genetics of dissociative disorders, as well as of clinically significant dissociative symptoms not reaching the threshold of a disorder, is reviewed comprehensively across clinical and non-clinical samples. Association studies suggest a link between dissociative symptoms and genes related to serotonergic, dopaminergic and peptidergic transmission, neural plasticity and cortisol receptor sensitivity, particularly following exposure to childhood trauma. Genome-wide association studies have identified loci of interest related to second messenger signaling and synaptic integration. Though these findings are inconsistent, they suggest biologically plausible mechanisms through which traumatic stress can lead to pathological dissociation. However, methodological concerns related to phenotype definition, study power, and correction for the confounding factors limit the value of these findings, and they require replication and extension in studies with better design. Full article

Introduction: Working during the COVID-19 pandemic is a particular challenge for nurses because, while performing their daily routines, they are exposed to physical and social consequences of the SARS-CoV-2 virus, which is accompanied by intensified stress. The aim of this study was to assess the intensity of stress and coping strategies applied by nurses working with both infected and non-infected patients with SARS-CoV-2 virus during the COVID-19 pandemic. Materials and Methods: The study was conducted between January and March 2021. Due to the epidemiological situation, the questionnaire was posted on Facebook in nurses’ groups and sent out via the “Messenger” and “WhatsApp” applications. Stress intensity was assessed by means of the Perceived Stress Scale (PSS-10), whereas coping strategies were assessed using the Mini-COPE stress coping inventory. Results: Among 151 surveyed nurses, more than half (52.3%) worked with infected patients and the remaining ones (47.7%) worked with non-infected patients. The level of stress perceived by nurses working with infected patients was higher than among nurses working with patients without SARS-CoV-2 infection (22.22 ± 5.94 vs. 20.21 ± 5.68, p = 0.03). The nurses working with infected patients were most likely to choose coping strategies focused on the problem (2.00 ± 0.62) and emotions (2.01 ± 0.69), whereas those working with non-infected patients usually chose strategies focused only on the problem (2.11 ± 0.58). Conclusions: During the COVID-19 pandemic, nurses working with SARS-CoV-2 patients experienced more intense stress than those working with non-infected patients. Nurses working with SARS-CoV-2 patients tended to cope with stress using strategies focused on the problem and on emotions, while those working with non-infected patients were more likely to choose strategies focused only on the problem. Full article

Hallucinogens are a loosely defined group of compounds including LSD, N,N-dimethyltryptamines, mescaline, psilocybin/psilocin, and 2,5-dimethoxy-4-methamphetamine (DOM), which can evoke intense visual and emotional experiences. We are witnessing a renaissance of research interest in hallucinogens, driven by increasing awareness of their psychotherapeutic potential. As such, we now present a narrative review of the literature on hallucinogen binding in vitro and ex vivo, and the various molecular imaging studies with positron emission tomography (PET) or single photon emission computer tomography (SPECT). In general, molecular imaging can depict the uptake and binding distribution of labelled hallucinogenic compounds or their congeners in the brain, as was shown in an early PET study with N¹-([¹¹C]-methyl)-2-bromo-LSD ([¹¹C]-MBL); displacement with the non-radioactive competitor ketanserin confirmed that the majority of [¹¹C]-MBL specific binding was to serotonin 5-HT_2A receptors. However, interactions at serotonin 5HT_1A and other classes of receptors and pleotropic effects on second messenger pathways may contribute to the particular experiential phenomenologies of LSD and other hallucinogenic compounds. Other salient aspects of hallucinogen action include permeability to the blood–brain barrier, the rates of metabolism and elimination, and the formation of active metabolites. Despite the maturation of radiochemistry and molecular imaging in recent years, there has been only a handful of PET or SPECT studies of radiolabeled hallucinogens, most recently using the 5-HT_2A/2C agonist N-(2[¹¹CH₃O]-methoxybenzyl)-2,5-dimethoxy- 4-bromophenethylamine ([¹¹C]Cimbi-36). In addition to PET studies of target engagement at neuroreceptors and transporters, there is a small number of studies on the effects of hallucinogenic compounds on cerebral perfusion ([¹⁵O]-water) or metabolism ([¹⁸F]-fluorodeoxyglucose/FDG). There remains considerable scope for basic imaging research on the sites of interaction of hallucinogens and their cerebrometabolic effects; we expect that hybrid imaging with PET in conjunction with functional magnetic resonance imaging (fMRI) should provide especially useful for the next phase of this research. Full article

Social isolation during the pandemic contributed to the transition of educational processes to e-learning. A short-term e-marketing education program for a variety of students was introduced in May 2020 and is taught entirely online. A survey was conducted regularly in the last week of training using Google Forms, and three cohorts were surveyed in July, September, and December 2020. A high level of satisfaction indicates an interest in the content and a positive assessment of the level of comfort of an organization adapted to the needs of students; this positive result contrasted with the negative opinion of the remote learning in Russia since March 2020, and this surprising satisfaction of students has motivated the study to try to explain its reasons. This result was compared with the short-term course taught through the educational pedagogical platform of a university. The students of traditional short- and long-term university programs were asked to assess their satisfaction with different digital communication tools used for e-learning. They showed low satisfaction with the pedagogical platform and a positive reaction to the e-communication tools (messengers, social media, short surveys, video conferences, etc.). The qualitative responses helped to better understand the real problems of the cognitive process and the triple structure of intellectual production during e-learning, including interest in the intellectual outcome, the need for emotional and motivational elements of cooperation and competition between students, and smooth behavioral enrichment, which requires special efforts from students and their leading from teachers. The main conclusion concerns a practical decision to continue the implementation of the educational program in the form of an online course with the use of the mixed digital communication tools of social media, messengers, and video conferences, which most likely meets the expectations and capabilities of students. Full article

With the development of Internet technologies, chat environments have migrated from PCs to mobile devices. Conversations have moved from phone calls and text messages to mobile messaging services or “messengers,” which has led to a significant surge in the use of mobile messengers such as Line and WhatsApp. However, because these messengers mainly use text as the communication medium, they have the inherent disadvantage of not effectively representing the user’s nonverbal expressions. In this context, we propose a new emotional communication messenger that improves upon the limitations of existing static expressions in current messenger applications. We develop a chat messenger based on augmented reality (AR) technology using smartglasses, which are a type of a wearable device. To this end, we select a server model that is suitable for AR, and we apply an effective emotional expression method based on 16 different basic emotions classified as per Russell’s model. In our app, these emotions can be expressed via emojis, animations, particle effects, and sound clips. Finally, we verify the efficacy of our messenger by conducting a user study to compare it with current 2D-based messenger services. Our messenger service can serve as a prototype for future AR-based messenger apps. Full article

Doxing is the searching for and intentional disclosure of private information about a particular individual on the Internet without his or her consent, and is often used to exact punishment. The aim of this study was to investigate the associations between doxing victimization and emotional problems in secondary school students, paying particular regard to the impacts of different types of doxed information, the relationship between the perpetrators and victims of doxing, and the nature of the online platforms where doxing occurs. A sample of 2120 Hong Kong secondary school students of differing socioeconomic backgrounds participated in the study. The results show that almost all types of disclosed personal information result in negative feelings in victims, including depression, anxiety, and stress. Girls were also found to be more likely than boys to be doxed. Significant associations were found between emotional problems and the disclosure of mobile phone numbers and personal photos and videos; doxing conducted by schoolmates and anxiety and depression, and doxing through Instant Messenger and anxiety. Further exploration of integrated cyber violence prevention programs and research on the details of doxing are recommended. Full article

Traumatic brain injury (TBI) is one of the leading causes of mortality worldwide and leads to persistent cognitive, sensory, motor dysfunction, and emotional disorders. TBI-caused primary injury results in structural damage to brain tissues. Following the primary injury, secondary injuries which are accompanied by neuroinflammation, microglial activation, and additional cell death subsequently occur. Platonin, a cyanine photosensitizing dye, has been used to treat trauma, ulcers, and some types of acute inflammation. In the present study, the neuroprotective effects of platonin against TBI were explored in a controlled cortical impact (CCI) injury model in mice. Treatment with platonin (200 µg/kg) significantly reduced the neurological severity score, general locomotor activity, and anxiety-related behavior, and improved the rotarod performance of CCI-injured mice. In addition, platonin reduced lesion volumes, the expression of cleaved caspase-3, and microglial activation in TBI-insulted brains. Platonin also suppressed messenger (m)RNA levels of caspase-3, caspase-1, cyclooxygenase-2, tumor necrosis factor-α, interleukin-6, and interleukin-1β. On the other hand, free radical production after TBI was obviously attenuated in platonin-treated mice. Treatment with platonin exhibited prominent neuroprotective properties against TBI in a CCI mouse model through its anti-inflammatory, anti-apoptotic, and anti-free radical capabilities. This evidence collectively indicates that platonin may be a potential therapeutic medicine for use with TBIs. Full article

Successful long-term programs for urban residential food waste sorting are very rare, despite the established urgent need for them in cities for waste reduction, pollution reduction and circular resource economy reasons. This study meets recent calls to bridge policy makers and academics, and calls for more thorough analysis of operational work in terms of behavioral determinants, to move the fields on. It takes a key operational element of a recently reported successful food waste sorting program—manning of the new bins by volunteers—and considers the behavioral determinants involved in order to design a more scalable and cheaper alternative—the use of brightly colored covers with flower designs on three sides of the bin. The two interventions were tested in a medium-scale, real-life experimental set-up that showed that they had statistically similar results: high effective capture rates of 32%–34%, with low contamination rates. The success, low cost and simple implementation of the latter suggests it should be considered for large-scale use. Candidate behavioral determinants are prompts, emotion and knowledge for the yellow bin intervention, and for the volunteer intervention they are additionally social influence, modeling, role clarification, and moderators of messenger type and interpersonal or tailored messaging. Full article