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Open AccessArticle

Neuroprotective Effects of Platonin, a Therapeutic Immunomodulating Medicine, on Traumatic Brain Injury in Mice after Controlled Cortical Impact

1
Department of Medical Research, Cathay General Hospital, Taipei 22174, Taiwan
2
Department of Pharmacology, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
3
Department of Cardiology, Cathay General Hospital, Taipei 10630, Taiwan
4
Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University Hospital, Taipei 11031, Taiwan.
5
School of Respiratory Therapy, Division of Thoracic medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(4), 1100; https://doi.org/10.3390/ijms19041100
Received: 31 January 2018 / Revised: 2 April 2018 / Accepted: 3 April 2018 / Published: 6 April 2018
(This article belongs to the Special Issue Molecular Pharmacology and Pathology of Strokes)
Traumatic brain injury (TBI) is one of the leading causes of mortality worldwide and leads to persistent cognitive, sensory, motor dysfunction, and emotional disorders. TBI-caused primary injury results in structural damage to brain tissues. Following the primary injury, secondary injuries which are accompanied by neuroinflammation, microglial activation, and additional cell death subsequently occur. Platonin, a cyanine photosensitizing dye, has been used to treat trauma, ulcers, and some types of acute inflammation. In the present study, the neuroprotective effects of platonin against TBI were explored in a controlled cortical impact (CCI) injury model in mice. Treatment with platonin (200 µg/kg) significantly reduced the neurological severity score, general locomotor activity, and anxiety-related behavior, and improved the rotarod performance of CCI-injured mice. In addition, platonin reduced lesion volumes, the expression of cleaved caspase-3, and microglial activation in TBI-insulted brains. Platonin also suppressed messenger (m)RNA levels of caspase-3, caspase-1, cyclooxygenase-2, tumor necrosis factor-α, interleukin-6, and interleukin-1β. On the other hand, free radical production after TBI was obviously attenuated in platonin-treated mice. Treatment with platonin exhibited prominent neuroprotective properties against TBI in a CCI mouse model through its anti-inflammatory, anti-apoptotic, and anti-free radical capabilities. This evidence collectively indicates that platonin may be a potential therapeutic medicine for use with TBIs. View Full-Text
Keywords: traumatic brain injury; platonin; neuroinflammation; microglial activation; free radical traumatic brain injury; platonin; neuroinflammation; microglial activation; free radical
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MDPI and ACS Style

Yen, T.-L.; Chang, C.-C.; Chung, C.-L.; Ko, W.-C.; Yang, C.-H.; Hsieh, C.-Y. Neuroprotective Effects of Platonin, a Therapeutic Immunomodulating Medicine, on Traumatic Brain Injury in Mice after Controlled Cortical Impact. Int. J. Mol. Sci. 2018, 19, 1100. https://doi.org/10.3390/ijms19041100

AMA Style

Yen T-L, Chang C-C, Chung C-L, Ko W-C, Yang C-H, Hsieh C-Y. Neuroprotective Effects of Platonin, a Therapeutic Immunomodulating Medicine, on Traumatic Brain Injury in Mice after Controlled Cortical Impact. International Journal of Molecular Sciences. 2018; 19(4):1100. https://doi.org/10.3390/ijms19041100

Chicago/Turabian Style

Yen, Ting-Lin; Chang, Chao-Chien; Chung, Chi-Li; Ko, Wen-Chin; Yang, Chih-Hao; Hsieh, Cheng-Ying. 2018. "Neuroprotective Effects of Platonin, a Therapeutic Immunomodulating Medicine, on Traumatic Brain Injury in Mice after Controlled Cortical Impact" Int. J. Mol. Sci. 19, no. 4: 1100. https://doi.org/10.3390/ijms19041100

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